PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22467513-0 2012 Conditional expression of Lodavin, an avidin-tagged LDL receptor, for biotin-mediated applications in vivo. lodavin 26-33 low density lipoprotein receptor Mus musculus 52-64 22467513-0 2012 Conditional expression of Lodavin, an avidin-tagged LDL receptor, for biotin-mediated applications in vivo. Biotin 70-76 low density lipoprotein receptor Mus musculus 52-64 22467513-1 2012 Lodavin represents an engineered fusion protein that consists of a cytoplasmic and a transmembrane domain of the human low-density lipoprotein receptor coupled to an extracellular avidin monomer. lodavin 0-7 low density lipoprotein receptor Homo sapiens 119-151 22467513-3 2012 We engineered a Rosa26 (R26R) knock-in Lodavin mouse to develop biotin-based applications such as targeted drug delivery, cell purification, and tissue imaging in vivo. Biotin 64-70 gene trap ROSA 26, Philippe Soriano Mus musculus 16-22 22467513-5 2012 Efficient removal of the floxed betageo cassette and conditional activation of Lodavin expression was achieved as a result of crossing the R26RLodavin mice with HoxB7-Cre, Wnt4-Cre, or Tie1-Cre mice. lodavin 79-86 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 Mus musculus 185-189 11386853-5 2001 The wild-type and two mutant forms of the hPAH protein (R270K and V388M) were expressed in the presence of glycerol in the culture medium. Glycerol 107-115 phenylalanine hydroxylase Homo sapiens 42-46 11386853-7 2001 The results obtained demonstrate that glycerol not only improved the yield of the soluble hPAH proteins (2- to 3-fold depending on the mutant enzyme) produced but also increased the specific activity of the purified recombinant enzymes. Glycerol 38-46 phenylalanine hydroxylase Homo sapiens 90-94 11344302-3 2001 Rck2 phosphorylation was transiently increased during osmostress or in mutants with a hyperactive high osmolarity glycerol (HOG) pathway. Glycerol 114-122 serine/threonine protein kinase RCK2 Saccharomyces cerevisiae S288C 0-4 11406270-4 2001 Glycerol gradients revealed the sedimentation profile of transcripts containing intron rI1 in native C. reinhardtii extracts and in deproteinized RNA preparations, thus indicating the association of rI1 containing transcripts with high molecular weight ribonucleoprotein complexes in vivo. Glycerol 0-8 protein phosphatase 1, regulatory (inhibitor) subunit 1A Rattus norvegicus 87-90 11406270-4 2001 Glycerol gradients revealed the sedimentation profile of transcripts containing intron rI1 in native C. reinhardtii extracts and in deproteinized RNA preparations, thus indicating the association of rI1 containing transcripts with high molecular weight ribonucleoprotein complexes in vivo. Glycerol 0-8 protein phosphatase 1, regulatory (inhibitor) subunit 1A Rattus norvegicus 199-202 11389983-0 2001 Release of PEGylated granulocyte-macrophage colony-stimulating factor from chitosan/glycerol films. Glycerol 84-92 colony stimulating factor 2 Homo sapiens 21-69 11389983-1 2001 We have prepared a new formulation for mucosal delivery of GM-CSF or PEGylated GM-CSF based on a chitosan carrier plus added glycerol to control the rate of release of the protein. Glycerol 125-133 colony stimulating factor 2 Homo sapiens 79-85 11389983-3 2001 The amount of GM-CSF or PEG-(GM-CSF) released from the chitosan/glycerol films was determined using size exclusion high performance liquid chromatography (HPLC-SEC). Glycerol 64-72 colony stimulating factor 2 Homo sapiens 14-20 11389983-3 2001 The amount of GM-CSF or PEG-(GM-CSF) released from the chitosan/glycerol films was determined using size exclusion high performance liquid chromatography (HPLC-SEC). Glycerol 64-72 colony stimulating factor 2 Homo sapiens 29-35 11389983-4 2001 The amount of PEG-(GM-CSF) released from the films decreased with an increase in the amount of glycerol present in the film. Glycerol 95-103 colony stimulating factor 2 Homo sapiens 19-25 11389983-10 2001 The decrease in the fraction of PEG-(GM-CSF) released with increasing PEG molecular weight is believed to be due to the increased steric hindrance of the PEGylated protein molecule during its diffusion out of the swollen chitosan/glycerol film. Glycerol 230-238 colony stimulating factor 2 Homo sapiens 37-43 11278394-11 2001 In the mutant, Deltagpd1/gpd2, lacking glycerol biosynthesis, the stress response was magnified with a partially different set of up-regulated ORFs. Glycerol 39-47 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 Saccharomyces cerevisiae S288C 25-29 11344240-7 2001 On the other hand, 24-h exposure to 10 nmol/L IL-6 increased basal glycerol release by 42 +/- 12% (P < 0.01) and isoproterenol-induced glycerol release by 21 +/- 6% (P < 0.05). Glycerol 67-75 interleukin 6 Homo sapiens 46-50 11344240-7 2001 On the other hand, 24-h exposure to 10 nmol/L IL-6 increased basal glycerol release by 42 +/- 12% (P < 0.01) and isoproterenol-induced glycerol release by 21 +/- 6% (P < 0.05). Glycerol 138-146 interleukin 6 Homo sapiens 46-50 11499573-3 2001 We studied HGF mRNA and protein levels in systemic organs of glycerol-induced ARF rats, a model of crush syndrome. Glycerol 61-69 hepatocyte growth factor Rattus norvegicus 11-14 11254462-5 2001 Infusion of the rat amylin antagonist amylin-(8-37) (125 nmol/h) induced opposite basal plasma changes to amylin, i.e., lowered plasma NEFA, glycerol, glucose, and insulin levels (all P < 0.05 vs. control); additionally, amylin-(8-37) blocked amylin-induced elevations of these parameters (P < 0.01). Glycerol 141-149 islet amyloid polypeptide Rattus norvegicus 20-26 11321294-3 2001 Adding glycerol to acidified aqueous solutions of cytochrome c shifts the most abundant charge state from 17+ to 21+, shifts the maximum charge state from 20+ to 23+, and shifts the average charge state from 16.6+ to 20.9+. Glycerol 7-15 cytochrome c, somatic Homo sapiens 50-62 11308323-2 2001 Among the growth/induction media used, buffered minimal glycerol (BMG)/buffered minimal methanol (BMM) media were best for the production of glycosylated bovine beta-casein, indicating pH-dependent glycosylation. Glycerol 56-64 casein beta Bos taurus 161-172 11240205-6 2001 Both cryoprotectants sorbitol and glycerol significantly (P < 0.01) enhanced enzyme preservation, particularly cathepsin D and the activity on myofibrils, even at a freezing temperature of -20 degrees C. Glycerol 34-42 cathepsin D Bos taurus 114-125 11171108-2 2001 Anhydrothrombin was prepared from PMSF-inactivated thrombin under alkaline conditions, and the folded anhydrothrombin was successfully recovered after dialysis in the presence of glycerol. Glycerol 179-187 coagulation factor II, thrombin Homo sapiens 7-15 11253941-3 2001 It was found that by adding 20% glycerol into the inner aqueous phase and 40% acetone into the oil phase, smooth microspheres approximately 1 microm in diameter could be produced with high hCG entrapment efficiency (>90%). Glycerol 32-40 chorionic gonadotropin subunit beta 5 Homo sapiens 189-192 11253941-5 2001 The initial hCG burst from PLGA microspheres increased with the glycerol concentration in the inner aqueous phase, but decreased to a low value (ca. Glycerol 64-72 chorionic gonadotropin subunit beta 5 Homo sapiens 12-15 11254462-5 2001 Infusion of the rat amylin antagonist amylin-(8-37) (125 nmol/h) induced opposite basal plasma changes to amylin, i.e., lowered plasma NEFA, glycerol, glucose, and insulin levels (all P < 0.05 vs. control); additionally, amylin-(8-37) blocked amylin-induced elevations of these parameters (P < 0.01). Glycerol 141-149 islet amyloid polypeptide Rattus norvegicus 38-44 11254462-5 2001 Infusion of the rat amylin antagonist amylin-(8-37) (125 nmol/h) induced opposite basal plasma changes to amylin, i.e., lowered plasma NEFA, glycerol, glucose, and insulin levels (all P < 0.05 vs. control); additionally, amylin-(8-37) blocked amylin-induced elevations of these parameters (P < 0.01). Glycerol 141-149 islet amyloid polypeptide Rattus norvegicus 38-44 11254462-5 2001 Infusion of the rat amylin antagonist amylin-(8-37) (125 nmol/h) induced opposite basal plasma changes to amylin, i.e., lowered plasma NEFA, glycerol, glucose, and insulin levels (all P < 0.05 vs. control); additionally, amylin-(8-37) blocked amylin-induced elevations of these parameters (P < 0.01). Glycerol 141-149 islet amyloid polypeptide Rattus norvegicus 38-44 11254462-5 2001 Infusion of the rat amylin antagonist amylin-(8-37) (125 nmol/h) induced opposite basal plasma changes to amylin, i.e., lowered plasma NEFA, glycerol, glucose, and insulin levels (all P < 0.05 vs. control); additionally, amylin-(8-37) blocked amylin-induced elevations of these parameters (P < 0.01). Glycerol 141-149 islet amyloid polypeptide Rattus norvegicus 38-44 11254462-6 2001 Treatment with acipimox (10 mg/kg), an anti-lipolytic agent, before or after amylin infusion blocked amylin"s effects on plasma NEFA, glycerol, and insulin but not on glucose and lactate. Glycerol 134-142 islet amyloid polypeptide Rattus norvegicus 101-107 11359348-5 2001 Agents which inhibit gluconeogenesis more distally - namely at the level of glucose-6-phosphatase or of fructosediphosphatase - may prevent the gluconeogenic response to glycerol, making glycerol-rescued hypoglycemic therapy of cancer feasible. Glycerol 170-178 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 76-97 11359348-5 2001 Agents which inhibit gluconeogenesis more distally - namely at the level of glucose-6-phosphatase or of fructosediphosphatase - may prevent the gluconeogenic response to glycerol, making glycerol-rescued hypoglycemic therapy of cancer feasible. Glycerol 187-195 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 76-97 11359348-7 2001 Insulin also can inhibit gluconeogenesis, both proximally and distally, and can potentiate hypoglycemia by promoting muscle glucose uptake; thus, coinfusion of high-dose insulin and of glycerol may represent an alternative viable strategy. Glycerol 185-193 insulin Homo sapiens 0-7 11238886-7 2001 Using glycerol gradient sedimentation, we found that SBP2 was stably associated with the ribosomal fraction of cell lysates and that this interaction was not dependent on its SECIS binding activity. Glycerol 6-14 SECIS binding protein 2 Homo sapiens 53-57 11243726-3 2001 In the present study, we have evaluated the association among the mGPD H264R sequence variation and postabsorptive plasma FFA and glycerol concentrations in a sample of French Canadians with and without type 2 DM. Glycerol 130-138 atypical chemokine receptor 1 (Duffy blood group) Mus musculus 66-70 11243726-6 2001 The association of mGPD H264R sequence variation with plasma FFA and glycerol concentrations was assessed in different regression models. Glycerol 69-77 atypical chemokine receptor 1 (Duffy blood group) Mus musculus 19-23 11243726-11 2001 In the absence of DM, the mGPD R allele was also associated with higher plasma glycerol concentrations (P < 0.05). Glycerol 79-87 atypical chemokine receptor 1 (Duffy blood group) Mus musculus 26-30 11058603-3 2001 We report here that a msc2 strain shows a phenotype of decreased viability in glycerol-ethanol media at 37 degrees C. Associated with decreased growth is an abnormal morphology typified by an increase in size of both cells and vacuoles. Glycerol 78-86 metal cation transporter MSC2 Saccharomyces cerevisiae S288C 22-26 11058591-0 2001 The yeast glycerol 3-phosphatases Gpp1p and Gpp2p are required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic, anaerobic, and oxidative stress. Glycerol 10-18 glycerol-1-phosphatase RHR2 Saccharomyces cerevisiae S288C 34-39 11058591-0 2001 The yeast glycerol 3-phosphatases Gpp1p and Gpp2p are required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic, anaerobic, and oxidative stress. Glycerol 10-18 glycerol-1-phosphatase HOR2 Saccharomyces cerevisiae S288C 44-49 11058591-2 2001 Mutants lacking both GPP1 and GPP2 are devoid of glycerol 3-phosphatase activity and produce only a small amount of glycerol, confirming the essential role for this enzyme in glycerol biosynthesis. Glycerol 49-57 glycerol-1-phosphatase RHR2 Saccharomyces cerevisiae S288C 21-25 11058591-2 2001 Mutants lacking both GPP1 and GPP2 are devoid of glycerol 3-phosphatase activity and produce only a small amount of glycerol, confirming the essential role for this enzyme in glycerol biosynthesis. Glycerol 49-57 glycerol-1-phosphatase HOR2 Saccharomyces cerevisiae S288C 30-34 11058591-2 2001 Mutants lacking both GPP1 and GPP2 are devoid of glycerol 3-phosphatase activity and produce only a small amount of glycerol, confirming the essential role for this enzyme in glycerol biosynthesis. Glycerol 116-124 glycerol-1-phosphatase RHR2 Saccharomyces cerevisiae S288C 21-25 11058591-2 2001 Mutants lacking both GPP1 and GPP2 are devoid of glycerol 3-phosphatase activity and produce only a small amount of glycerol, confirming the essential role for this enzyme in glycerol biosynthesis. Glycerol 116-124 glycerol-1-phosphatase HOR2 Saccharomyces cerevisiae S288C 30-34 11058591-4 2001 Previous studies have shown that expression of both GPP1 and GPP2 is induced under hyperosmotic stress and that induction partially depends on the HOG (high osmolarity glycerol) pathway. Glycerol 168-176 glycerol-1-phosphatase RHR2 Saccharomyces cerevisiae S288C 52-56 11058591-4 2001 Previous studies have shown that expression of both GPP1 and GPP2 is induced under hyperosmotic stress and that induction partially depends on the HOG (high osmolarity glycerol) pathway. Glycerol 168-176 glycerol-1-phosphatase HOR2 Saccharomyces cerevisiae S288C 61-65 11058591-11 2001 Consistent with a role for glycerol 3-phosphatase in protection against oxidative stress, expression of GPP2 is induced in the presence of paraquat. Glycerol 27-35 glycerol-1-phosphatase HOR2 Saccharomyces cerevisiae S288C 104-108 11272131-7 2001 AGAT-alpha overexpression in adipocytes increased basal (130%, P = 0.04) and insulin-stimulated (27%, P = 0.01) [3H]OA uptake, increased insulin-stimulated glucose uptake (56%, P = 0.04) and conversion to cellular lipids (85%, P = 0.007), and suppressed basal (-44%, P = 0.01) and isoproterenol-stimulated OA release (-45%, P = 0.03) but not glycerol release. Glycerol 342-350 insulin Homo sapiens 77-84 11294499-6 2001 The highest correlation for the % decrease of glycerol Ra from baseline was found at 60 min (r = 0.96, p < 0.001) making this parameter a useful index for the antilipoytic insulin sensitivity. Glycerol 46-54 insulin Homo sapiens 175-182 11294499-9 2001 In healthy subjects, the parameter best suited to estimate the insulin EC50 (by linear correlation) was the percentage decrease of glycerol Ra at 60 min. Glycerol 131-139 insulin Homo sapiens 63-70 11240372-3 2001 In the presence of glycerol, L-arginine and/or tetrahydrobiopterin, the sodium cholate-treated P-420 form could be reconverted to the P-450 form under constant experimental conditions, and the nNOS activity could also be restored. Glycerol 19-27 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 134-139 11240372-3 2001 In the presence of glycerol, L-arginine and/or tetrahydrobiopterin, the sodium cholate-treated P-420 form could be reconverted to the P-450 form under constant experimental conditions, and the nNOS activity could also be restored. Glycerol 19-27 nitric oxide synthase 1 Homo sapiens 193-197 11240372-8 2001 After removing the urea by dialysis, and supplementation of the nNOS solution with glycerol, L-arginine or BH(4), the P-420 was reconverted to the P-450 form, and the reassociation of nNOS monomers was also observed. Glycerol 83-91 nitric oxide synthase 1 Homo sapiens 64-68 11321508-6 2001 Mannitol and glycerol, known scavengers of hydroxyl radical, arrest the elevation in lipid peroxidation of erythrocytes after LPS treatment. Glycerol 13-21 interferon regulatory factor 6 Homo sapiens 126-129 11289604-3 2001 Actin organization was examined using a combination of optimized immunofluorescence techniques, and an improved fluorochrome-conjugated phalloidin labeling method reliant on 3-maleimidobenzoyl-N-hydroxy-succinimide ester (MBS) cross-linking combined with glycerol permeabilization. Glycerol 255-263 actin-7 Zea mays 0-5 11118327-6 2000 Glycerol gradient sedimentation analysis revealed that MSS1 is included in protein complexes whose density is lighter than that of the proteasome. Glycerol 0-8 proteasome 26S subunit, ATPase 2 Homo sapiens 55-59 11231003-0 2001 Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family. Glycerol 15-23 aquaporin 3 Mus musculus 0-11 11231003-0 2001 Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family. Glycerol 15-23 transformation related protein 73 Mus musculus 63-66 11231003-0 2001 Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family. Glycerol 15-23 transformation related protein 53, pseudogene Mus musculus 74-77 11096062-13 2001 Cross-linking experiments and glycerol-gradient centrifugation analysis showed that the mammalian Apg7p homolog forms a homodimer as in yeast Apg7p. Glycerol 30-38 Atg7p Saccharomyces cerevisiae S288C 98-103 11035042-1 2001 Aquaporin (AQP) water channel AQP3 has been proposed to be the major glycerol and non-AQP1 water transporter in erythrocytes. Glycerol 69-77 aquaporin 3 Mus musculus 30-34 11206412-0 2001 Distinct long-term regulation of glycerol and non-esterified fatty acid release by insulin and TNF-alpha in 3T3-L1 adipocytes. Glycerol 33-41 insulin Homo sapiens 83-90 11206412-0 2001 Distinct long-term regulation of glycerol and non-esterified fatty acid release by insulin and TNF-alpha in 3T3-L1 adipocytes. Glycerol 33-41 tumor necrosis factor Homo sapiens 95-104 11206412-2 2001 Our study was to assess the long-term regulation of glycerol and non-esterified fatty acid (NEFA) release by insulin or TNF-alpha. Glycerol 52-60 insulin Homo sapiens 109-116 11206412-2 2001 Our study was to assess the long-term regulation of glycerol and non-esterified fatty acid (NEFA) release by insulin or TNF-alpha. Glycerol 52-60 tumor necrosis factor Homo sapiens 120-129 11206412-4 2001 RESULTS: Long-term insulin treatment resulted in increased basal glycerol release, reaching sixfold at 22 h with 1 nmol/l insulin. Glycerol 65-73 insulin Homo sapiens 19-26 11206412-4 2001 RESULTS: Long-term insulin treatment resulted in increased basal glycerol release, reaching sixfold at 22 h with 1 nmol/l insulin. Glycerol 65-73 insulin Homo sapiens 122-129 11206412-7 2001 The cellular mechanism seemed to be distinct from that of TNF-alpha: First, glycerol release in response to long-term insulin was progressive with time and did not display a lag-time characteristic of the effect of TNF-alpha. Glycerol 76-84 insulin Homo sapiens 118-125 11206412-8 2001 Second, pretreatment and co-treatment of the cells with troglitazone greatly inhibited TNF-alpha-induced glycerol release (128.5 +/- 10.2 to 35.4 +/- 2.1 nmol/mg protein per h) but not the effect of insulin, which was exaggerated. Glycerol 105-113 tumor necrosis factor Homo sapiens 87-96 11206412-12 2001 CONCLUSIONS INTERPRETATION: Contradictory to its short-term inhibitory effect, long-term insulin stimulates glycerol release with concomitant stimulation of NEFA re-esterification. Glycerol 108-116 insulin Homo sapiens 89-96 11170581-5 2001 Glycerol was used as a plasticizer (0.05-0.47 g/g of keratin), and films were stored at a constant relative humidity (20, 30, 50, 70, or 90%). Glycerol 0-8 keratin Gallus gallus 53-60 10995761-5 2000 Additionally, IRS-2(-)(/-) mice also showed marked insulin resistance in adipose tissue as reflected by reduced suppression of plasma free fatty acid concentrations and glycerol turnover during the hyperinsulinemic-euglycemic clamp. Glycerol 169-177 insulin receptor substrate 2 Mus musculus 14-19 11171166-3 2000 The chemical complementation of the mutant phenotype by exogenous glycerol treatment of gly1 plants suggests a lesion affecting the glycerol 3-phosphate supply within the chloroplast. Glycerol 66-74 NAD-dependent glycerol-3-phosphate dehydrogenase family protein Arabidopsis thaliana 88-92 11136466-8 2001 Consistent with this observation, DNA microarray studies revealed transcriptional induction of many known high-osmolarity glycerol (HOG) pathway-dependent genes, including four cell wall-related genes, namely CWP1, HOR7, SPI1 and YGP1. Glycerol 122-130 Cwp1p Saccharomyces cerevisiae S288C 209-213 11136466-8 2001 Consistent with this observation, DNA microarray studies revealed transcriptional induction of many known high-osmolarity glycerol (HOG) pathway-dependent genes, including four cell wall-related genes, namely CWP1, HOR7, SPI1 and YGP1. Glycerol 122-130 Hor7p Saccharomyces cerevisiae S288C 215-219 11136466-8 2001 Consistent with this observation, DNA microarray studies revealed transcriptional induction of many known high-osmolarity glycerol (HOG) pathway-dependent genes, including four cell wall-related genes, namely CWP1, HOR7, SPI1 and YGP1. Glycerol 122-130 Spi1p Saccharomyces cerevisiae S288C 221-225 11136466-8 2001 Consistent with this observation, DNA microarray studies revealed transcriptional induction of many known high-osmolarity glycerol (HOG) pathway-dependent genes, including four cell wall-related genes, namely CWP1, HOR7, SPI1 and YGP1. Glycerol 122-130 Ygp1p Saccharomyces cerevisiae S288C 230-234 11104574-0 2000 Glycerol restores p53-dependent radiosensitivity of human head and neck cancer cells bearing mutant p53. Glycerol 0-8 tumor protein p53 Homo sapiens 18-21 11104574-0 2000 Glycerol restores p53-dependent radiosensitivity of human head and neck cancer cells bearing mutant p53. Glycerol 0-8 tumor protein p53 Homo sapiens 100-103 11104574-3 2000 We examined the restoration of radiation-induced p53-dependent apoptosis by a chemical chaperone (glycerol) in human head and neck cancer cells (SAS cells, showing wild-type p53 phenotype). Glycerol 98-106 tumor protein p53 Homo sapiens 49-52 11104574-3 2000 We examined the restoration of radiation-induced p53-dependent apoptosis by a chemical chaperone (glycerol) in human head and neck cancer cells (SAS cells, showing wild-type p53 phenotype). Glycerol 98-106 tumor protein p53 Homo sapiens 174-177 11104574-4 2000 SAS cells transfected with mutant p53 (SAS/m p53) showed radioresistance compared with SAS cells (SAS/ neo) transfected with neo vector as a control, but became radiosensitive when pre-treated with glycerol before X-ray irradiation. Glycerol 198-206 tumor protein p53 Homo sapiens 34-37 11104574-4 2000 SAS cells transfected with mutant p53 (SAS/m p53) showed radioresistance compared with SAS cells (SAS/ neo) transfected with neo vector as a control, but became radiosensitive when pre-treated with glycerol before X-ray irradiation. Glycerol 198-206 tumor protein p53 Homo sapiens 45-48 11104574-5 2000 Apoptosis in the SAS/m p53 cells was induced by X-rays with glycerol pre-treatment, but not without glycerol pre-treatment, whereas apoptosis in the SAS/ neo cells was induced in both cases. Glycerol 60-68 tumor protein p53 Homo sapiens 23-26 11104574-6 2000 Gel mobility-shift assays showed that after X-ray irradiation combined with glycerol pre-treatment, mp53 was able to bind to the sequence-specific region upstream of the bax gene regulating apoptosis. Glycerol 76-84 BCL2 associated X, apoptosis regulator Homo sapiens 170-173 11104574-7 2000 These results suggest that glycerol is effective in inducing a conformational change of p53 and restoring normal function to mp53, leading to enhanced radiosensitivity through the induction of apoptosis. Glycerol 27-35 tumor protein p53 Homo sapiens 88-91 11142398-1 2000 Cytosolic glycerol kinase (Gut1p) and mitochondrial glycerol-3-phosphate dehydrogenase (Gut2p) constitute the glycerol utilization pathway in Saccharomyces cerevisiae. Glycerol 10-18 glycerol kinase Saccharomyces cerevisiae S288C 27-32 11142398-1 2000 Cytosolic glycerol kinase (Gut1p) and mitochondrial glycerol-3-phosphate dehydrogenase (Gut2p) constitute the glycerol utilization pathway in Saccharomyces cerevisiae. Glycerol 10-18 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 88-93 11142398-2 2000 Transcriptional analysis of the GUT2 gene showed that it was repressed by glucose and derepressed on the non-fermentable carbon sources, glycerol, lactate and ethanol. Glycerol 137-145 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 32-36 11201997-3 2000 2-MG that accumulate on the chylomicra surface have been proposed to isomerize spontaneously to 1(3)-MG, which are then hydrolyzed by LPL to free fatty acids and glycerol. Glycerol 162-170 lipoprotein lipase Homo sapiens 134-137 11113971-7 2000 At low demand for NADH reoxidation via glycerol formation, the GPD1, GPD2, GPP1, and GPP2 genes were all expressed at basal levels. Glycerol 39-47 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 63-67 11113971-7 2000 At low demand for NADH reoxidation via glycerol formation, the GPD1, GPD2, GPP1, and GPP2 genes were all expressed at basal levels. Glycerol 39-47 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 Saccharomyces cerevisiae S288C 69-73 11113971-7 2000 At low demand for NADH reoxidation via glycerol formation, the GPD1, GPD2, GPP1, and GPP2 genes were all expressed at basal levels. Glycerol 39-47 glycerol-1-phosphatase RHR2 Saccharomyces cerevisiae S288C 75-79 11113971-7 2000 At low demand for NADH reoxidation via glycerol formation, the GPD1, GPD2, GPP1, and GPP2 genes were all expressed at basal levels. Glycerol 39-47 glycerol-1-phosphatase HOR2 Saccharomyces cerevisiae S288C 85-89 11113971-8 2000 The dynamics of the gene induction and the glycerol formation at low demand for NADH reoxidation point to an important role of the Gpd1p; deletion of the GPD1 gene strongly altered the expression patterns of the GPD2 and GPP1 genes under such conditions. Glycerol 43-51 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 131-136 11113971-8 2000 The dynamics of the gene induction and the glycerol formation at low demand for NADH reoxidation point to an important role of the Gpd1p; deletion of the GPD1 gene strongly altered the expression patterns of the GPD2 and GPP1 genes under such conditions. Glycerol 43-51 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 154-158 11113971-8 2000 The dynamics of the gene induction and the glycerol formation at low demand for NADH reoxidation point to an important role of the Gpd1p; deletion of the GPD1 gene strongly altered the expression patterns of the GPD2 and GPP1 genes under such conditions. Glycerol 43-51 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 Saccharomyces cerevisiae S288C 212-216 11042136-12 2000 Lipase activity and NMR analysis of the second peak showed that fatty acids esterified the primary alcohol group on each glycerol moiety. Glycerol 121-129 lipase G, endothelial type Rattus norvegicus 0-6 11053145-0 2000 Molecular dynamics of solid-state lysozyme as affected by glycerol and water: a neutron scattering study. Glycerol 58-66 lysozyme Homo sapiens 34-42 11053145-1 2000 Glycerol has been shown to lower the heat denaturation temperature (T(m)) of dehydrated lysozyme while elevating the T(m) of hydrated lysozyme (. Glycerol 0-8 lysozyme Homo sapiens 88-96 11053145-1 2000 Glycerol has been shown to lower the heat denaturation temperature (T(m)) of dehydrated lysozyme while elevating the T(m) of hydrated lysozyme (. Glycerol 0-8 lysozyme Homo sapiens 134-142 11053145-5 2000 Here, we report an in situ elastic neutron scattering study of the effect of glycerol and hydration on the internal dynamics of lysozyme powder. Glycerol 77-85 lysozyme Homo sapiens 128-136 11053145-8 2000 Upon the addition of glycerol or water, anharmonicity was recovered above a dynamic transition temperature (T(d)), which may contribute to the reduction of T(m) values for dehydrated lysozyme in the presence of glycerol. Glycerol 21-29 lysozyme Homo sapiens 183-191 11053145-8 2000 Upon the addition of glycerol or water, anharmonicity was recovered above a dynamic transition temperature (T(d)), which may contribute to the reduction of T(m) values for dehydrated lysozyme in the presence of glycerol. Glycerol 211-219 lysozyme Homo sapiens 183-191 11040087-1 2000 In order to define the ability of bovine lens aldose reductase (ALR2) to generate polyols from aldoses, the quantitative determination of glycerol in the presence of glyceraldehyde was performed by gas chromatography after derivatization with trifluoroacetic anhydride. Glycerol 138-146 aldose reductase Bos taurus 46-62 11040087-1 2000 In order to define the ability of bovine lens aldose reductase (ALR2) to generate polyols from aldoses, the quantitative determination of glycerol in the presence of glyceraldehyde was performed by gas chromatography after derivatization with trifluoroacetic anhydride. Glycerol 138-146 lens aldose reductase pseudogene Bos taurus 64-68 11040087-3 2000 The generation of one equivalent of glycerol in the presence of ALR2, is paralleled by the oxidation of one equivalent of NADPH. Glycerol 36-44 lens aldose reductase pseudogene Bos taurus 64-68 11040087-6 2000 The demonstration of the stoichiometric ratio of 1:1 occurring in the presence of bovine lens ALR2 between the synthesis of glycerol from D, L -glyceraldehyde and the oxidation of NADPH, rules out doubts concerning the ability of the enzyme to catalyse the reduction of aldoses to the corresponding polyalcohols. Glycerol 124-132 lens aldose reductase pseudogene Bos taurus 94-98 11053257-4 2000 2) In CFPAC-1 cells, cAMP fails to stimulate Cl-/HCO3- exchange and Cl- channels, except after promoting surface expression of DeltaF508-CFTR by glycerol treatment. Glycerol 145-153 CF transmembrane conductance regulator Homo sapiens 137-141 11054825-4 2000 However, disruption of YDL077c (also known as VAM6) exhibited an slow growth phenotype in minimal media and also in rich media containing glycerol as a carbon source. Glycerol 138-146 VPS39 subunit of HOPS complex Homo sapiens 46-50 11040353-0 2000 Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure. Glycerol 55-63 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 27-41 11040353-1 2000 The effect of glycerol-induced acute renal failure on P-glycoprotein expression and function was evaluated in rats. Glycerol 14-22 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 54-68 11040449-0 2000 DMSO and glycerol reduce bacterial death induced by expression of truncated N-terminal huntingtin with expanded polyglutamine tracts. Glycerol 9-17 huntingtin Mus musculus 87-97 11040449-6 2000 These results suggest that DMSO and glycerol may decrease the toxicity of huntingtin with expanded polyglutamine tracts by acting as chemical chaperones. Glycerol 36-44 huntingtin Mus musculus 74-84 11042259-2 2000 Deletion of SGD1 results in loss of cell viability, while an increased dosage of SGD1 partially suppresses the osmosensitivity of pbs2 delta and hog1 delta mutants that are defective in the osmosignaling high osmolarity glycerol (HOG) mitogen-activated protein kinase pathway. Glycerol 220-228 Sgd1p Saccharomyces cerevisiae S288C 81-85 11042259-2 2000 Deletion of SGD1 results in loss of cell viability, while an increased dosage of SGD1 partially suppresses the osmosensitivity of pbs2 delta and hog1 delta mutants that are defective in the osmosignaling high osmolarity glycerol (HOG) mitogen-activated protein kinase pathway. Glycerol 220-228 mitogen-activated protein kinase kinase PBS2 Saccharomyces cerevisiae S288C 130-134 11042259-3 2000 The rescued mutants display a partially re-established transcriptional control of the osmostress-induced expression of GPD1, a target gene of the HOG pathway encoding NAD(+)-dependent glycerol 3-phosphate dehydrogenase, and a partially recovered hyperosmolarity-induced production of glycerol. Glycerol 184-192 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 119-123 11038180-2 2000 Here, we show that mitochondrial fragmentation and mitochondrial genome loss caused by lesions in MGM1 are suppressed by three novel mutations, gag1, gag2, and gag3 (for glycerol-adapted growth). Glycerol 170-178 dynamin-related GTPase MGM1 Saccharomyces cerevisiae S288C 98-102 11038180-2 2000 Here, we show that mitochondrial fragmentation and mitochondrial genome loss caused by lesions in MGM1 are suppressed by three novel mutations, gag1, gag2, and gag3 (for glycerol-adapted growth). Glycerol 170-178 Mdv1p Saccharomyces cerevisiae S288C 160-164 11014451-3 2000 The fragmentation pathway for the formation of the [M - H - RxCO2H]- ions, reflecting neutral loss of fatty acid, is a charge-remote process, which involves the participation of the hydrogens at C-1 and C-2 of the glycerol, resulting in [M - H - R2CO2H]- > [M - H - R1CO2H]-. Glycerol 214-222 heterogeneous nuclear ribonucleoprotein C Homo sapiens 195-198 11090844-5 2000 Upon incubation with porcine pancreatic phospholipase A(2), only compounds with a fatty acid in the sn-2 position of the glycerol backbone were degraded. Glycerol 121-129 phospholipase A and acyltransferase 1 Homo sapiens 40-55 11014451-3 2000 The fragmentation pathway for the formation of the [M - H - RxCO2H]- ions, reflecting neutral loss of fatty acid, is a charge-remote process, which involves the participation of the hydrogens at C-1 and C-2 of the glycerol, resulting in [M - H - R2CO2H]- > [M - H - R1CO2H]-. Glycerol 214-222 complement C2 Homo sapiens 203-206 11014451-6 2000 The major pathway for the formation of RxCO2- ions arises from the nucleophilic attack of the anionic charge site of the phosphate on the C-1 or C-2 of the glycerol to render a charge transfer. Glycerol 156-164 heterogeneous nuclear ribonucleoprotein C Homo sapiens 138-141 11014451-6 2000 The major pathway for the formation of RxCO2- ions arises from the nucleophilic attack of the anionic charge site of the phosphate on the C-1 or C-2 of the glycerol to render a charge transfer. Glycerol 156-164 complement C2 Homo sapiens 145-148 11014451-7 2000 The sterically more favorable attack on the C-2 than C-2 of the glycerol results in the abundance of R2CO2- > R1CO2-. Glycerol 64-72 complement C2 Homo sapiens 44-47 11014451-7 2000 The sterically more favorable attack on the C-2 than C-2 of the glycerol results in the abundance of R2CO2- > R1CO2-. Glycerol 64-72 complement C2 Homo sapiens 53-56 11069666-1 2000 Saccharomyces cerevisiae strains lacking a functional Pho85 cyclin-dependent kinase (cdk) exhibit a complex phenotype, including deregulation of phosphatase genes controlled by the transcription factor Pho4, slow growth on rich media, failure to grow using galactose, lactate or glycerol as a carbon source and hyperaccumulation of glycogen. Glycerol 279-287 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 54-59 10960096-0 2000 Cooperative regulation of DOG2, encoding 2-deoxyglucose-6-phosphate phosphatase, by Snf1 kinase and the high-osmolarity glycerol-mitogen-activated protein kinase cascade in stress responses of Saccharomyces cerevisiae. Glycerol 120-128 2-deoxyglucose-6-phosphatase Saccharomyces cerevisiae S288C 26-30 11068916-6 2000 The strains that produced significant glycerol exhibited efficient expression of the glycerol-3-phosphate dehydrogenase gene GPD1. Glycerol 38-46 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 85-119 11068916-6 2000 The strains that produced significant glycerol exhibited efficient expression of the glycerol-3-phosphate dehydrogenase gene GPD1. Glycerol 38-46 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 125-129 11048642-7 2000 The sedimentation profile of the MAPK module kinases in a glycerol gradient showed the presence of a rather homogeneous species of multimeric forms of ERK1/2 and MEK as indicated by the narrow distribution peak areas. Glycerol 58-66 mitogen-activated protein kinase 3 Mus musculus 151-157 11048642-7 2000 The sedimentation profile of the MAPK module kinases in a glycerol gradient showed the presence of a rather homogeneous species of multimeric forms of ERK1/2 and MEK as indicated by the narrow distribution peak areas. Glycerol 58-66 midkine Mus musculus 162-165 11048642-8 2000 The broad sedimentation profile of the Raf-1 in a glycerol gradient may suggest possible heterologous protein complexes but the identification of interacting molecules still remains to be identified in order to understand the organization of the MAPK signal transduction pathway. Glycerol 50-58 v-raf-leukemia viral oncogene 1 Mus musculus 39-44 10842169-2 2000 The GPD1 gene encodes NAD(+)-dependent glycerol-3-phosphate dehydrogenase, a key enzyme in the production of the compatible solute glycerol. Glycerol 39-47 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 4-8 11007982-0 2000 Functional identification of the glycerol permease activity of Arabidopsis thaliana NLM1 and NLM2 proteins by heterologous expression in Saccharomyces cerevisiae. Glycerol 33-41 NOD26-like major intrinsic protein 1 Arabidopsis thaliana 84-88 11007982-0 2000 Functional identification of the glycerol permease activity of Arabidopsis thaliana NLM1 and NLM2 proteins by heterologous expression in Saccharomyces cerevisiae. Glycerol 33-41 NOD26-like intrinsic protein 1;2 Arabidopsis thaliana 93-97 11007982-1 2000 NLM proteins (NOD26-like major intrinsic proteins) from plants contain amino acid sequence signatures which can be found in aquaporins including plant plasma membrane intrinsic proteins and tonoplast intrinsic proteins and glycerol permeases such as the Escherichia coli GlpF and the yeast FPS1 proteins. Glycerol 223-231 Fps1p Saccharomyces cerevisiae S288C 290-294 12192339-6 2000 Colief Infant Drops consist of lactase in a glycerol and water solution which, when added to formula or breast milk, converts lactose to simple sugars and makes the feed more easily digestible. Glycerol 44-52 lactase Homo sapiens 31-38 10970855-1 2000 The adaptive response to hyperosmotic stress in yeast, termed the high osmolarity glycerol (HOG) response, is mediated by two independent upstream pathways that converge on the Pbs2 MAP kinase kinase (MAPKK), leading to the activation of the Hog1 MAP kinase. Glycerol 82-90 mitogen-activated protein kinase kinase PBS2 Saccharomyces cerevisiae S288C 177-181 10970855-1 2000 The adaptive response to hyperosmotic stress in yeast, termed the high osmolarity glycerol (HOG) response, is mediated by two independent upstream pathways that converge on the Pbs2 MAP kinase kinase (MAPKK), leading to the activation of the Hog1 MAP kinase. Glycerol 82-90 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 242-246 10940042-4 2000 A total of 53 open reading frames (ORFs) were identified as GCR1 dependent based on the criterion that their expression was reduced twofold or greater in mutant versus wild-type cultures grown in permissive medium consisting of YP supplemented with glycerol and lactate. Glycerol 249-257 transcription regulator GCR1 Saccharomyces cerevisiae S288C 60-64 10975408-0 2000 Glycerol disrupts tight junction-associated actin microfilaments, occludin, and microtubules in Sertoli cells. Glycerol 0-8 occludin Rattus norvegicus 66-74 10975408-8 2000 In contrast, in glycerol-treated Sertoli cells, microfilament and microtubule organization and occludin distribution were partially or completely disrupted. Glycerol 16-24 occludin Rattus norvegicus 95-103 10975408-9 2000 From these results we conclude that glycerol treatment either directly or indirectly disrupts tight junction-associated F-actin and occludin and tubulin organization in rat Sertoli cells. Glycerol 36-44 occludin Rattus norvegicus 132-140 10960096-9 2000 These results suggest that Snf1p kinase and the high-osmolarity glycerol-mitogen-activated protein kinase cascade are likely to be involved in the signaling pathway of oxidative stress and osmotic stress in regulation of DOG2. Glycerol 64-72 2-deoxyglucose-6-phosphatase Saccharomyces cerevisiae S288C 221-225 10921904-6 2000 Glycerol gradient sedimentation and immunoprecipitation assays demonstrate that the acetylation of histones by p300 facilitates the transfer of H2A-H2B from nucleosomes to NAP-1. Glycerol 0-8 E1A binding protein p300 Homo sapiens 111-115 10930580-4 2000 When expressed in a yme1 disruptant yeast strain, YME1L restored growth on glycerol at 37 degrees C. We propose that YME1L plays a phylogenetically conserved role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Glycerol 75-83 i-AAA protease YME1 Saccharomyces cerevisiae S288C 20-24 10913038-10 2000 Furthermore, interstitial glycerol data suggest that training also increases insulin sensitivity of lipolysis in subcutaneous adipose tissue. Glycerol 26-34 insulin Homo sapiens 77-84 10903144-9 2000 When DMKP was expressed in yeast, it down-regulated the fus1-lacZ trans-reporter gene of the pheromone MAPK pathway without any significant effect on the high-osmolarity-glycerol-response pathway. Glycerol 170-178 MAP kinase-specific phosphatase Drosophila melanogaster 5-9 10921904-6 2000 Glycerol gradient sedimentation and immunoprecipitation assays demonstrate that the acetylation of histones by p300 facilitates the transfer of H2A-H2B from nucleosomes to NAP-1. Glycerol 0-8 nucleosome assembly protein 1 like 1 Homo sapiens 172-177 10931309-0 2000 GUP1 and its close homologue GUP2, encoding multimembrane-spanning proteins involved in active glycerol uptake in Saccharomyces cerevisiae. Glycerol 95-103 O-acyltransferase Saccharomyces cerevisiae S288C 0-4 10777495-1 2000 Adipose tissue is a major site of glycerol production in response to energy balance. Glycerol 34-42 WD and tetratricopeptide repeats 1 Mus musculus 0-7 10777495-3 2000 We recently cloned a novel member of the aquaporin family, aquaporin adipose (AQPap), which has glycerol permeability. Glycerol 96-104 aquaporin 7 Mus musculus 59-76 10777495-3 2000 We recently cloned a novel member of the aquaporin family, aquaporin adipose (AQPap), which has glycerol permeability. Glycerol 96-104 aquaporin 7 Mus musculus 78-83 10777495-6 2000 Glycerol release from 3T3-L1 cells was increased during differentiation in parallel with AQPap mRNA levels and suppressed by mercury ion, which inhibits the function of AQPs, supporting AQPap functions as a glycerol channel in adipocytes. Glycerol 0-8 aquaporin 7 Mus musculus 89-94 10777495-6 2000 Glycerol release from 3T3-L1 cells was increased during differentiation in parallel with AQPap mRNA levels and suppressed by mercury ion, which inhibits the function of AQPs, supporting AQPap functions as a glycerol channel in adipocytes. Glycerol 0-8 aquaporin 7 Mus musculus 186-191 10777495-6 2000 Glycerol release from 3T3-L1 cells was increased during differentiation in parallel with AQPap mRNA levels and suppressed by mercury ion, which inhibits the function of AQPs, supporting AQPap functions as a glycerol channel in adipocytes. Glycerol 207-215 aquaporin 7 Mus musculus 186-191 10777495-7 2000 Fasting increased and refeeding suppressed adipose AQPap mRNA levels in accordance with plasma glycerol levels and oppositely to plasma insulin levels in mice. Glycerol 95-103 WD and tetratricopeptide repeats 1 Mus musculus 43-50 10777495-7 2000 Fasting increased and refeeding suppressed adipose AQPap mRNA levels in accordance with plasma glycerol levels and oppositely to plasma insulin levels in mice. Glycerol 95-103 aquaporin 7 Mus musculus 51-56 10777495-12 2000 These results strongly suggest that AQPap plays an important role in glycerol release from adipocytes. Glycerol 69-77 aquaporin 7 Mus musculus 36-41 10875252-9 2000 Glycerol gradient analysis revealed cosedimentation of IDE with the 20S proteasome and possibly with the 26S proteasome. Glycerol 0-8 insulin degrading enzyme Homo sapiens 55-58 10931309-0 2000 GUP1 and its close homologue GUP2, encoding multimembrane-spanning proteins involved in active glycerol uptake in Saccharomyces cerevisiae. Glycerol 95-103 putative O-acyltransferase Saccharomyces cerevisiae S288C 29-33 10931309-5 2000 The gene is named GUP1 (glycerol uptake) and, for growth on glycerol, is important as a carbon and energy source. Glycerol 24-32 O-acyltransferase Saccharomyces cerevisiae S288C 18-22 10931309-5 2000 The gene is named GUP1 (glycerol uptake) and, for growth on glycerol, is important as a carbon and energy source. Glycerol 60-68 O-acyltransferase Saccharomyces cerevisiae S288C 18-22 10931288-2 2000 Consistently, mutant strains gpd1gpd2 and gpp1gpp2, which are devoid of the main glycerol biosynthesis pathway, have been shown to be osmosensitive. Glycerol 81-89 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 29-37 11776180-9 2000 Serum leptin levels in pregnant women were positively correlated with their body weight, BMI, fasting serum insulin and glycerol levels. Glycerol 120-128 leptin Homo sapiens 6-12 10866041-6 2000 Adipocytes isolated from AFABP-KO and WT mice fed high- or low-fat diets exhibited similar rates of basal and norepinephrine-stimulated lipolysis and insulin-stimulated rates of glucose conversion to fatty acids and glyceride-glycerol. Glycerol 226-234 fatty acid binding protein 4, adipocyte Mus musculus 25-30 10931288-2 2000 Consistently, mutant strains gpd1gpd2 and gpp1gpp2, which are devoid of the main glycerol biosynthesis pathway, have been shown to be osmosensitive. Glycerol 81-89 glycerol-1-phosphatase RHR2 Saccharomyces cerevisiae S288C 42-50 10931288-5 2000 A hog1 deletion strain was previously found to contain lower internal glycerol and therefore displays an osmosensitive phenotype. Glycerol 70-78 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 2-6 10931288-6 2000 Here, we show that the osmosensitivity of hog1 is suppressed by growth at 37 degrees C. We reasoned that this temperature-remedial osmoresistance might be caused by a higher intracellular glycerol level at the elevated temperature. Glycerol 188-196 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 42-46 10931288-7 2000 This hypothesis was confirmed by measurement of the glycerol concentration, which was shown to be similar for wild type and hog1 cells only at elevated growth temperatures. Glycerol 52-60 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 124-128 10931288-8 2000 In agreement with this finding, hog1 cells containing an fps1 allele, encoding a constitutively open glycerol channel, have lost their temperature-remedial osmoresistance. Glycerol 101-109 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 32-36 10825542-8 2000 It is hypothesized that the thermal unfolding in glycerol follows the scheme: N ifho-MG-->U, where N is a native-like conformation, ho-MG is a highly ordered molten globule state, and U is the unfolded state of the protein. Glycerol 49-57 transient receptor potential cation channel subfamily M member 6 Homo sapiens 82-87 10799492-8 2000 At steady state in glycerol these transcripts have very short poly(A) tails but are nevertheless very stable; the addition of glucose causes immediate decapping and degradation without further deadenylation; in contrast, newly made SUC2 mRNA (after a shift from glucose to glycerol) has significantly longer poly(A) tails, and such transcripts are not rapidly degraded upon addition of glucose. Glycerol 273-281 beta-fructofuranosidase SUC2 Saccharomyces cerevisiae S288C 232-236 10762242-1 2000 We have isolated several Saccharomyces cerevisiae mutants resistant to calcofluor that contain mutations in the PBS2 or HOG1 genes, which encode the mitogen-activated protein kinase (MAPK) and MAP kinases, respectively, of the high-osmolarity glycerol response (HOG) pathway. Glycerol 243-251 mitogen-activated protein kinase kinase PBS2 Saccharomyces cerevisiae S288C 112-116 10844611-10 2000 The exposure of the kidney to a single injection of hypertonic glycerol increased the expression of both cytokines some three to five days following this exposure, while the exposure of NRK 49F cells in culture to an iron-dependent model of oxidative stress also increased expression of TGF-beta1 and collagen mRNAs. Glycerol 63-71 transforming growth factor, beta 1 Rattus norvegicus 287-296 10736265-1 2000 Glycerol kinase (GK) represents the primary entry of glycerol into glucose and triglyceride metabolism. Glycerol 53-61 glycerol kinase Homo sapiens 0-15 10736265-1 2000 Glycerol kinase (GK) represents the primary entry of glycerol into glucose and triglyceride metabolism. Glycerol 53-61 glycerol kinase Homo sapiens 17-19 10762242-1 2000 We have isolated several Saccharomyces cerevisiae mutants resistant to calcofluor that contain mutations in the PBS2 or HOG1 genes, which encode the mitogen-activated protein kinase (MAPK) and MAP kinases, respectively, of the high-osmolarity glycerol response (HOG) pathway. Glycerol 243-251 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 120-124 10781551-8 2000 An nde1Delta nde2Delta mutant already produced glycerol at specific growth rates of 0.10 h(-1) and above, indicating a requirement for external NADH dehydrogenase to sustain fully respiratory growth. Glycerol 47-55 NADH-ubiquinone reductase (H(+)-translocating) NDE1 Saccharomyces cerevisiae S288C 3-7 10781551-9 2000 An nde1Delta nde2Delta gut2Delta mutant produced even larger amounts of glycerol at specific growth rates ranging from 0.05 to 0.15 h(-1). Glycerol 72-80 NADH-ubiquinone reductase (H(+)-translocating) NDE1 Saccharomyces cerevisiae S288C 3-7 10781551-9 2000 An nde1Delta nde2Delta gut2Delta mutant produced even larger amounts of glycerol at specific growth rates ranging from 0.05 to 0.15 h(-1). Glycerol 72-80 NADH-ubiquinone reductase (H(+)-translocating) NDE2 Saccharomyces cerevisiae S288C 13-17 10844654-9 2000 In addition, INM1 expression was repressed during growth in glycerol and derepressed as glucose-grown cells entered stationary. Glycerol 60-68 inositol monophosphate 1-phosphatase INM1 Saccharomyces cerevisiae S288C 13-17 11031603-1 2000 By using the kerosene-glycerin system for which the mu/T ratio (mu being the relative viscosity and T the interfacial tension between the fluids) is about ten times higher than that for the commonly used air-glycerin system, we have been able to access the hitherto unexplored Nca greater than approximately 1 regime (capillary number Nca = U mu/T, U being the advancing fingertip velocity). Glycerol 22-30 CEA cell adhesion molecule 6 Homo sapiens 277-280 11031603-1 2000 By using the kerosene-glycerin system for which the mu/T ratio (mu being the relative viscosity and T the interfacial tension between the fluids) is about ten times higher than that for the commonly used air-glycerin system, we have been able to access the hitherto unexplored Nca greater than approximately 1 regime (capillary number Nca = U mu/T, U being the advancing fingertip velocity). Glycerol 22-30 CEA cell adhesion molecule 6 Homo sapiens 335-338 10766782-2 2000 Saccharomyces cerevisiae lacking copper-zinc superoxide dismutase (sod1) shows a series of defects, including reduced rates of aerobic growth in synthetic glucose medium and reduced ability to grow by respiration in glycerol-rich medium. Glycerol 216-224 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 67-71 10775416-5 2000 A met7 gly1 strain is auxotrophic for glycine when grown on glucose but prototrophic when grown on glycerol. Glycerol 99-107 tetrahydrofolate synthase Saccharomyces cerevisiae S288C 2-6 10775416-5 2000 A met7 gly1 strain is auxotrophic for glycine when grown on glucose but prototrophic when grown on glycerol. Glycerol 99-107 threonine aldolase GLY1 Saccharomyces cerevisiae S288C 7-11 10744740-0 2000 ASC1/RAS2 suppresses the growth defect on glycerol caused by the atp1-2 mutation in the yeast Saccharomyces cerevisiae. Glycerol 42-50 guanine nucleotide-binding protein subunit beta Saccharomyces cerevisiae S288C 0-4 10744740-0 2000 ASC1/RAS2 suppresses the growth defect on glycerol caused by the atp1-2 mutation in the yeast Saccharomyces cerevisiae. Glycerol 42-50 Ras family GTPase RAS2 Saccharomyces cerevisiae S288C 5-9 10744740-0 2000 ASC1/RAS2 suppresses the growth defect on glycerol caused by the atp1-2 mutation in the yeast Saccharomyces cerevisiae. Glycerol 42-50 ATP synthase complex assembly protein ATP12 Saccharomyces cerevisiae S288C 65-71 10744740-8 2000 An unlinked suppressor gene, ASC1 (alpha-subunit complementing) of the atp1-2 mutation (Gly(291) --> Asp) restored the growth defect phenotype on glycerol, but did not suppress either atp1-1 or the deletion mutant Deltaatp1. Glycerol 149-157 guanine nucleotide-binding protein subunit beta Saccharomyces cerevisiae S288C 29-33 10744740-8 2000 An unlinked suppressor gene, ASC1 (alpha-subunit complementing) of the atp1-2 mutation (Gly(291) --> Asp) restored the growth defect phenotype on glycerol, but did not suppress either atp1-1 or the deletion mutant Deltaatp1. Glycerol 149-157 F1F0 ATP synthase subunit beta Saccharomyces cerevisiae S288C 71-77 10744740-10 2000 The introduction of ASC1/RAS2 into the atp1-2 mutant increased the F(1)-ATPase enzyme activity in this mutant when the transformant was grown on glycerol. Glycerol 145-153 guanine nucleotide-binding protein subunit beta Saccharomyces cerevisiae S288C 20-24 10744740-10 2000 The introduction of ASC1/RAS2 into the atp1-2 mutant increased the F(1)-ATPase enzyme activity in this mutant when the transformant was grown on glycerol. Glycerol 145-153 Ras family GTPase RAS2 Saccharomyces cerevisiae S288C 25-29 10744740-10 2000 The introduction of ASC1/RAS2 into the atp1-2 mutant increased the F(1)-ATPase enzyme activity in this mutant when the transformant was grown on glycerol. Glycerol 145-153 ATP synthase complex assembly protein ATP12 Saccharomyces cerevisiae S288C 39-45 10729188-9 2000 Similarly, glycerol enhanced protein levels of P-gp expressed under control of the GAL1 promoter. Glycerol 11-19 ATP binding cassette subfamily B member 1 Homo sapiens 47-51 10729188-9 2000 Similarly, glycerol enhanced protein levels of P-gp expressed under control of the GAL1 promoter. Glycerol 11-19 galactokinase Saccharomyces cerevisiae S288C 83-87 10729188-10 2000 Glycerol was demonstrated to enhance posttranslational stability of P-gp. Glycerol 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 68-72 11258590-7 2000 Maximal exercise increased CCK by 78.5 +/- 24.8 pmol/L(-1), (P < 0.05 vs. resting value) during the SL1 test and increased the plasma concentration of non-esterified fatty acids and glycerol at BC (P < 0.05 vs. SL1/SL2). Glycerol 185-193 cholecystokinin Homo sapiens 27-30 10760958-7 2000 Antibody to DNA-binding protein B co-extracts nucleolin from HeLa cell cytosol, and the two proteins co-sediment in glycerol gradient fractions of ribosomal high salt extracts. Glycerol 116-124 Y-box binding protein 1 Homo sapiens 12-33 10805445-6 2000 LIMP 2 is a multifunctional aquaglyceroporin, and displays the ability to flux both water as well as glycerol upon expression in Xenopus oocytes. Glycerol 101-109 LIMP2 Lotus japonicus 0-6 10705374-5 2000 In anaerobic batch fermentations of strain TN5 (gpd2-Delta1), formation of glycerol was significantly impaired, which resulted in reduction of the maximum specific growth rate from 0.41/h in the wild-type to 0.08/h. Glycerol 75-83 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 Saccharomyces cerevisiae S288C 48-52 10793064-4 2000 In the glycerol model of heme protein toxicity-one characterized by myolysis, hemolysis, and kidney damage-HO-1 is rapidly induced in the kidney of HO-1 +/+ mice as the latter sustain mild, reversible renal insufficiency without mortality. Glycerol 7-15 heme oxygenase 1 Mus musculus 107-111 10734090-4 2000 While the acyl dihydroxyacetone phosphate (acyl-DHAP) pathway for glycerolipid synthesis is commonly believed to be involved only in glycerol ether lipid synthesis, we report here that during conversion of 3T3-L1 preadipocytes to adipocytes, the specific activity of peroxisomal DHAP acyltransferase (DHAPAT) is increased by 9-fold in 6 days, while acyl-DHAP:NADPH reductase is induced by 5-fold. Glycerol 66-74 glyceronephosphate O-acyltransferase Mus musculus 279-299 10734090-4 2000 While the acyl dihydroxyacetone phosphate (acyl-DHAP) pathway for glycerolipid synthesis is commonly believed to be involved only in glycerol ether lipid synthesis, we report here that during conversion of 3T3-L1 preadipocytes to adipocytes, the specific activity of peroxisomal DHAP acyltransferase (DHAPAT) is increased by 9-fold in 6 days, while acyl-DHAP:NADPH reductase is induced by 5-fold. Glycerol 66-74 glyceronephosphate O-acyltransferase Mus musculus 301-307 10705374-7 2000 The modest effect of the GPD1 deletion under anaerobic conditions on the maximum specific growth rate and product yields clearly showed that Gdh2p is the important factor in glycerol formation during anaerobic growth. Glycerol 174-182 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 25-29 10705374-7 2000 The modest effect of the GPD1 deletion under anaerobic conditions on the maximum specific growth rate and product yields clearly showed that Gdh2p is the important factor in glycerol formation during anaerobic growth. Glycerol 174-182 glutamate dehydrogenase (NAD(+)) Saccharomyces cerevisiae S288C 141-146 10705374-10 2000 Deletion of either GPD1 or GPD2 in the wild-type resulted in a dramatic reduction of the glycerol yields in the aerobic batch cultivations of strains TN4 (gpd1-Delta1) and TN5 (gpd2-Delta1) without serious effects on the maximum specific growth rates or the biomass yields. Glycerol 89-97 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 19-23 10705374-10 2000 Deletion of either GPD1 or GPD2 in the wild-type resulted in a dramatic reduction of the glycerol yields in the aerobic batch cultivations of strains TN4 (gpd1-Delta1) and TN5 (gpd2-Delta1) without serious effects on the maximum specific growth rates or the biomass yields. Glycerol 89-97 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 Saccharomyces cerevisiae S288C 27-31 10722658-1 2000 Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes. Glycerol 83-91 Hot1p Saccharomyces cerevisiae S288C 0-5 10722658-1 2000 Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes. Glycerol 83-91 stress-responsive transcriptional activator MSN2 Saccharomyces cerevisiae S288C 10-15 10722658-1 2000 Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes. Glycerol 83-91 stress-responsive transcriptional activator MSN4 Saccharomyces cerevisiae S288C 16-21 10816823-2 2000 It was shown that PLA2 deacetylates the glycerol residue at position 2, PLC is inactive, and PLD hydrolyzes the phosphatidylnucleosides to give free nucleosides. Glycerol 40-48 phospholipase A2 group IB Homo sapiens 18-22 10879675-4 2000 The presence of leptin at concentrations of 10(-12) to 10(-7) M in the incubation medium of isolated fat cells significantly increased (p < 0.0001) glycerol release, except at the concentration of 10(-11) M, where the increase was (p < 0.01) as compared to the basal lipolytic activity. Glycerol 151-159 leptin Rattus norvegicus 16-22 10698161-7 2000 The effect of adrenaline on plasma concentration of both glycerol and nonesterified fatty acids was higher as lower was plasma EGF concentration. Glycerol 57-65 epidermal growth factor Mus musculus 127-130 10879675-5 2000 On the other hand, isolated fat cells of Wistar rats bathed in 10(-10) to 10(-6) M concentrations of NPY demonstrated a statistically significant decrease (p < 0.0001) in glycerol release. Glycerol 174-182 neuropeptide Y Rattus norvegicus 101-104 10751643-1 2000 Stimulated leukocytes generate platelet-activating factor (PAF) from membrane 1-O-alkyl-2-acyl-sn-glycerophosphocholine through hydrolysis of fatty acid and subsequent acetylation at the sn2 position of glycerol. Glycerol 203-211 PCNA clamp associated factor Homo sapiens 31-57 10751643-1 2000 Stimulated leukocytes generate platelet-activating factor (PAF) from membrane 1-O-alkyl-2-acyl-sn-glycerophosphocholine through hydrolysis of fatty acid and subsequent acetylation at the sn2 position of glycerol. Glycerol 203-211 PCNA clamp associated factor Homo sapiens 59-62 10684654-12 2000 In these measurements, higher glycerol concentrations increase rebinding (and decrease the fluorescence recovery rate) because the solution viscosity is increased and the Fab diffusion coefficient in solution is decreased. Glycerol 30-38 FA complementation group B Homo sapiens 171-174 10686598-3 2000 Expression of myosin heavy chain (MyHC) isoforms was detected with the immunoperoxidase method applying monoclonal antibodies against MyHC isoforms -1, -2a, -2x/d, and -2b, as well as by sodium dodecylsulfate (SDS) glycerol gel electrophoresis. Glycerol 215-223 myosin heavy chain, cardiac muscle complex Mus musculus 14-32 10686598-3 2000 Expression of myosin heavy chain (MyHC) isoforms was detected with the immunoperoxidase method applying monoclonal antibodies against MyHC isoforms -1, -2a, -2x/d, and -2b, as well as by sodium dodecylsulfate (SDS) glycerol gel electrophoresis. Glycerol 215-223 myosin heavy chain, cardiac muscle complex Mus musculus 34-38 10686598-9 2000 In one out of six muscles, traces of MyHC-1 were detected both with immunoperoxidase staining and with SDS glycerol gel electrophoresis. Glycerol 107-115 myosin heavy chain, cardiac muscle complex Mus musculus 37-41 10657248-1 2000 We studied interactions in vivo between the cytosolic muscle isoform of creatine kinase (M-CK) and the muscle isoform of 2-phospho-D-glycerate hydrolyase (beta-enolase) in muscle sarcoplasm by incubating glycerol-skinned fibres with FITC-labelled beta-enolase in the presence or absence of free CK. Glycerol 204-212 creatine kinase, M-type Homo sapiens 89-93 10657248-1 2000 We studied interactions in vivo between the cytosolic muscle isoform of creatine kinase (M-CK) and the muscle isoform of 2-phospho-D-glycerate hydrolyase (beta-enolase) in muscle sarcoplasm by incubating glycerol-skinned fibres with FITC-labelled beta-enolase in the presence or absence of free CK. Glycerol 204-212 enolase 3 Homo sapiens 155-167 10675611-5 2000 Nob1p was found only in proteasomal fractions in a glycerol gradient centrifugation profile and immuno-coprecipitated with Rpt1, which is an ATPase component of the yeast proteasomes. Glycerol 51-59 rRNA-binding endoribonuclease Saccharomyces cerevisiae S288C 0-5 10641035-4 2000 Proteins with increased expression during growth under sodium chloride stress could be grouped into three classes with respect to PKA activity, with the glycerol metabolic proteins GPD1, GPP2 and DAK1 standing out as independent of PKA. Glycerol 153-161 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 181-185 10641035-4 2000 Proteins with increased expression during growth under sodium chloride stress could be grouped into three classes with respect to PKA activity, with the glycerol metabolic proteins GPD1, GPP2 and DAK1 standing out as independent of PKA. Glycerol 153-161 glycerol-1-phosphatase HOR2 Saccharomyces cerevisiae S288C 187-191 10641035-4 2000 Proteins with increased expression during growth under sodium chloride stress could be grouped into three classes with respect to PKA activity, with the glycerol metabolic proteins GPD1, GPP2 and DAK1 standing out as independent of PKA. Glycerol 153-161 dihydroxyacetone kinase Saccharomyces cerevisiae S288C 196-200 10644694-8 2000 Selective removal of either the terminal mannose or the acyl residues esterifying the glycerol moiety of the ManLAM abrogates the interaction with hSP-A, further supporting the notion that the hSP-A recognition of the carbohydrate epitopes of the lipoglycans is dependent of the presence of the fatty acids. Glycerol 86-94 surfactant protein A1 Homo sapiens 147-152 10644694-8 2000 Selective removal of either the terminal mannose or the acyl residues esterifying the glycerol moiety of the ManLAM abrogates the interaction with hSP-A, further supporting the notion that the hSP-A recognition of the carbohydrate epitopes of the lipoglycans is dependent of the presence of the fatty acids. Glycerol 86-94 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 147-150 10612714-7 2000 The ratio hydrolysis without apo C II/hydrolysis with apo CII was different when other phospholipids than myrystoyl-phospatidylcholine were assayed: phosphatidyl-serine, ethanolamine, -choline, -glycerol, or diglycerides and butanoylglycerols. Glycerol 195-203 apolipoprotein C2 Bos taurus 54-61 10634941-6 2000 Upon stimulation of cells with the beta-adrenergic receptor agonist, isoproterenol, hormone-sensitive lipase translocates from the cytosol to the surfaces of intracellular lipid droplets concomitant with the onset of lipolysis, as measured by the release of glycerol to the culture medium. Glycerol 258-266 lipase, hormone sensitive Mus musculus 84-108 10581437-10 2000 It was found that the addition of glucose or glycerol to cultures with oxidoreductase expression produced the highest DBT removal rate (51 mg/h. Glycerol 45-53 oxidoreductase Escherichia coli 71-85 10644950-5 2000 We show that the decrease of solution water activity, due to the addition of sucrose, glycerol, ethylene glycol, and betaine, favors drug binding to the strong binding sites on DNA by increasing both the apparent binding affinity delta G, and the number of DNA base pairs apparently occupied by the bound drug nbp/actD. Glycerol 86-94 NUBP iron-sulfur cluster assembly factor 1, cytosolic Homo sapiens 310-313 10644652-6 2000 Several of the mammalian aquaporins (e.g., AQP1, AQP2, AQP4, and AQP5) appear to be highly selective for the passage of water, whereas others (recently termed aquaglyceroporins) also transport glycerol (e.g., AQP3 and AQP8) and even larger solutes (AQP9). Glycerol 193-201 aquaporin 1 (Colton blood group) Homo sapiens 43-47 10644652-6 2000 Several of the mammalian aquaporins (e.g., AQP1, AQP2, AQP4, and AQP5) appear to be highly selective for the passage of water, whereas others (recently termed aquaglyceroporins) also transport glycerol (e.g., AQP3 and AQP8) and even larger solutes (AQP9). Glycerol 193-201 aquaporin 5 Homo sapiens 65-69 10963339-4 2000 The GST-P was associated with the maltose-binding protein-tagged GRP94 (MBP-GRP94, 130 kDa) using analyses by an affinity chromatography, native gel electrophoresis and glycerol gradient centrifugation. Glycerol 169-177 heat shock protein 90 beta family member 1 Homo sapiens 65-70 10963339-4 2000 The GST-P was associated with the maltose-binding protein-tagged GRP94 (MBP-GRP94, 130 kDa) using analyses by an affinity chromatography, native gel electrophoresis and glycerol gradient centrifugation. Glycerol 169-177 heat shock protein 90 beta family member 1 Homo sapiens 76-81 10668857-3 2000 In addition to renal filtration, sorbitol [elimination half-life (t1/2beta) approximately 1h] and glycerol (t1/2beta 0.2 to 1h) are metabolised, mainly by the liver. Glycerol 98-106 interleukin 1 receptor like 1 Homo sapiens 108-116 16232830-0 2000 Enhanced glycerol production in Shochu yeast by heat-shock treatment is due to prolonged transcription of GPD1. Glycerol 9-17 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 106-110 16232830-3 2000 During the glycerol-production phase, the NAD+-dependent glycerol-3-phosphate dehydrogenase (GPDH) activity of heat-shock-treated cells was much higher than that of control cells, suggesting that a higher GPDH activity enhances glycerol production. Glycerol 11-19 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 57-91 16232830-3 2000 During the glycerol-production phase, the NAD+-dependent glycerol-3-phosphate dehydrogenase (GPDH) activity of heat-shock-treated cells was much higher than that of control cells, suggesting that a higher GPDH activity enhances glycerol production. Glycerol 11-19 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 93-97 16232830-3 2000 During the glycerol-production phase, the NAD+-dependent glycerol-3-phosphate dehydrogenase (GPDH) activity of heat-shock-treated cells was much higher than that of control cells, suggesting that a higher GPDH activity enhances glycerol production. Glycerol 11-19 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 205-209 16232830-3 2000 During the glycerol-production phase, the NAD+-dependent glycerol-3-phosphate dehydrogenase (GPDH) activity of heat-shock-treated cells was much higher than that of control cells, suggesting that a higher GPDH activity enhances glycerol production. Glycerol 57-65 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 93-97 16232830-3 2000 During the glycerol-production phase, the NAD+-dependent glycerol-3-phosphate dehydrogenase (GPDH) activity of heat-shock-treated cells was much higher than that of control cells, suggesting that a higher GPDH activity enhances glycerol production. Glycerol 57-65 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 205-209 10935936-7 2000 The resulting strain TN19 (gdh1-A1 PGK1p-GLT1 PGK1p-GLN1) had a 10% higher ethanol yield and a 38% lower glycerol yield compared to the wild type in anaerobic batch fermentations. Glycerol 105-113 glutamate dehydrogenase (NADP(+)) GDH1 Saccharomyces cerevisiae S288C 27-31 10935936-7 2000 The resulting strain TN19 (gdh1-A1 PGK1p-GLT1 PGK1p-GLN1) had a 10% higher ethanol yield and a 38% lower glycerol yield compared to the wild type in anaerobic batch fermentations. Glycerol 105-113 phosphoglycerate kinase Saccharomyces cerevisiae S288C 35-40 10935936-7 2000 The resulting strain TN19 (gdh1-A1 PGK1p-GLT1 PGK1p-GLN1) had a 10% higher ethanol yield and a 38% lower glycerol yield compared to the wild type in anaerobic batch fermentations. Glycerol 105-113 glutamate synthase (NADH) Saccharomyces cerevisiae S288C 41-45 10935936-7 2000 The resulting strain TN19 (gdh1-A1 PGK1p-GLT1 PGK1p-GLN1) had a 10% higher ethanol yield and a 38% lower glycerol yield compared to the wild type in anaerobic batch fermentations. Glycerol 105-113 phosphoglycerate kinase Saccharomyces cerevisiae S288C 46-51 10935936-7 2000 The resulting strain TN19 (gdh1-A1 PGK1p-GLT1 PGK1p-GLN1) had a 10% higher ethanol yield and a 38% lower glycerol yield compared to the wild type in anaerobic batch fermentations. Glycerol 105-113 glutamate--ammonia ligase Saccharomyces cerevisiae S288C 52-56 10585426-9 1999 Furthermore, it is found that glycerol can also activate the MKP3-catalyzed reaction, increase the affinity of MKP3 for oxyanion, and restore the bell-shaped pH rate profile for the MKP3-catalyzed reaction. Glycerol 30-38 dual specificity phosphatase 6 Homo sapiens 61-65 10585426-9 1999 Furthermore, it is found that glycerol can also activate the MKP3-catalyzed reaction, increase the affinity of MKP3 for oxyanion, and restore the bell-shaped pH rate profile for the MKP3-catalyzed reaction. Glycerol 30-38 dual specificity phosphatase 6 Homo sapiens 111-115 10585426-9 1999 Furthermore, it is found that glycerol can also activate the MKP3-catalyzed reaction, increase the affinity of MKP3 for oxyanion, and restore the bell-shaped pH rate profile for the MKP3-catalyzed reaction. Glycerol 30-38 dual specificity phosphatase 6 Homo sapiens 111-115 10585426-10 1999 Thus, the rate of repositioning of catalytic groups and the reorienting of the electrostatic environment in the MKP3 active site can be enhanced not only by ERK2 but also by high affinity substrates or by glycerol. Glycerol 205-213 dual specificity phosphatase 6 Homo sapiens 112-116 10574954-9 1999 After growth of cells for 48 h in the chemical chaperone glycerol, AQP2 mutants T126M and A147T became properly targeted and relatively detergent-soluble. Glycerol 57-65 aquaporin 2 Homo sapiens 67-71 10585740-5 1999 Six factors influenced CYP1A2-mediated MROD rates: buffer type, pH, temperature, Mg/EDTA, NADH, and glycerol. Glycerol 100-108 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 23-29 10658599-2 1999 PP2A in liver cytosol was greatly stabilized with 30% glycerol as a preliminary step in the potential use of endothal-type derivatives for affinity chromatography. Glycerol 54-62 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus 0-4 10599990-8 1999 This TSH-induced glycerol release was further enhanced by adenosine deaminase (ADA). Glycerol 17-25 adenosine deaminase Rattus norvegicus 58-77 10567692-2 1999 This work examines the role and regulation of GPD1 and GPD2, encoding two isoforms of glycerol 3-phosphate dehydrogenase, in glycerol production during iron starvation. Glycerol 86-94 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 46-50 10567692-2 1999 This work examines the role and regulation of GPD1 and GPD2, encoding two isoforms of glycerol 3-phosphate dehydrogenase, in glycerol production during iron starvation. Glycerol 86-94 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 Saccharomyces cerevisiae S288C 55-59 10567692-5 1999 Deletion of either GPD1 or GPD2 alters the capacity for glycerol production during iron-limited as well as iron sufficient conditions. Glycerol 56-64 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 19-23 10567692-5 1999 Deletion of either GPD1 or GPD2 alters the capacity for glycerol production during iron-limited as well as iron sufficient conditions. Glycerol 56-64 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 Saccharomyces cerevisiae S288C 27-31 10567692-8 1999 In agreement with the pattern of expression of GPD2, this gene product was estimated to account for the bulk of the glycerol production (about 60%) during iron-limited conditions. Glycerol 116-124 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 Saccharomyces cerevisiae S288C 47-51 10536147-1 1999 In Saccharomyces cerevisiae glycerol utilization is mediated by two enzymes, glycerol kinase (Gut1p) and mitochondrial glycerol-3-phosphate dehydrogenase (Gut2p). Glycerol 28-36 glycerol kinase Saccharomyces cerevisiae S288C 94-99 10536147-1 1999 In Saccharomyces cerevisiae glycerol utilization is mediated by two enzymes, glycerol kinase (Gut1p) and mitochondrial glycerol-3-phosphate dehydrogenase (Gut2p). Glycerol 28-36 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 119-153 10536147-1 1999 In Saccharomyces cerevisiae glycerol utilization is mediated by two enzymes, glycerol kinase (Gut1p) and mitochondrial glycerol-3-phosphate dehydrogenase (Gut2p). Glycerol 28-36 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 155-160 10536147-4 1999 Mutational analysis of the GUT1 promoter region showed that two upstream activation sequences, UAS(INO) and UAS(ADR1), are responsible for approximately 90% of the expression during growth on glycerol. Glycerol 192-200 glycerol kinase Saccharomyces cerevisiae S288C 27-31 10536147-4 1999 Mutational analysis of the GUT1 promoter region showed that two upstream activation sequences, UAS(INO) and UAS(ADR1), are responsible for approximately 90% of the expression during growth on glycerol. Glycerol 192-200 DNA-binding transcription factor ADR1 Saccharomyces cerevisiae S288C 112-116 10578212-12 1999 However, in the presence of leptin, the production of glucose from glycerol (2 mM), L-lactate (2 mM). Glycerol 67-75 leptin Rattus norvegicus 28-34 11114033-1 2000 Several triacylglycerol (TAG) molecular species, that contain two short-chain fatty acids (C4 to C8) at the sn-2 and sn-3 positions of the glycerol backbone, were isolated from bovine udder by using solvent extraction and silica gel column chromatography. Glycerol 15-23 solute carrier family 38 member 5 Bos taurus 108-112 10545275-6 1999 Orthorhombic crystals of the apoE 223-272 fragment that diffracted to 1.8 A were obtained in a mixture of 0.1 M imidazole (pH 6.0) and 0.4 M NaOAc (pH 7.0-7.5), containing 30% glycerol. Glycerol 176-184 apolipoprotein E Homo sapiens 29-33 10586425-0 1999 Protective effect of a bioflavonoid proanthocyanidin-BP1 in glycerol-induced acute renal failure in the rat: renal stereological study. Glycerol 60-68 Blood pressure QTL 1 Rattus norvegicus 36-56 10586425-3 1999 In this study the protective effect of a new bioflavonoid proanthocyanidin-BP1 (BP1), extracted from seeds of grapes, was evaluated in glycerol-induced ARF in rats. Glycerol 135-143 Blood pressure QTL 1 Rattus norvegicus 58-78 10586425-3 1999 In this study the protective effect of a new bioflavonoid proanthocyanidin-BP1 (BP1), extracted from seeds of grapes, was evaluated in glycerol-induced ARF in rats. Glycerol 135-143 Blood pressure QTL 1 Rattus norvegicus 75-78 10586425-12 1999 The results suggest that BP1 is a protective agent in glycerol model of ARF. Glycerol 54-62 Blood pressure QTL 1 Rattus norvegicus 25-28 10510269-5 1999 Expression of mRNA from the colon of adults and children but not from other gastrointestinal regions in Xenopus oocytes enhanced the osmotic water permeability, and the urea and glycerol transport in a manner sensitive to an antisense AQP3 oligonucleotide, indicating the presence of functional AQP3. Glycerol 178-186 aquaporin 3 (Gill blood group) S homeolog Xenopus laevis 235-239 10512363-3 1999 Beta-adrenergic stimulation resulted in a blunted rise of blood glycerol levels in aP2-/- compared with aP2+/+ mice, suggesting diminished lipolysis in aP2-/- adipocytes. Glycerol 64-72 fatty acid binding protein 4, adipocyte Mus musculus 83-86 10512363-4 1999 Confirming this, primary adipocytes isolated from aP2-/- mice showed attenuated glycerol and free fatty acid (FFA) release in response to dibutyryl cAMP. Glycerol 80-88 fatty acid binding protein 4, adipocyte Mus musculus 50-53 10523399-11 1999 In conclusion, glycerol-fructose administration resulted in hypertriglyceridemia, hyperinsulinemia, and increased vascular sensitivity to 12,13-phorbol dibutyrate (with respect to the control group), and significantly greater expression of protein kinase C alpha and betaII (with respect to the glycerol group). Glycerol 15-23 protein kinase C, alpha Rattus norvegicus 240-262 10523399-11 1999 In conclusion, glycerol-fructose administration resulted in hypertriglyceridemia, hyperinsulinemia, and increased vascular sensitivity to 12,13-phorbol dibutyrate (with respect to the control group), and significantly greater expression of protein kinase C alpha and betaII (with respect to the glycerol group). Glycerol 295-303 protein kinase C, alpha Rattus norvegicus 240-262 10528916-0 1999 Restoration by glycerol of p53-dependent apoptosis in cells bearing the mutant p53 gene. Glycerol 15-23 transformation related protein 53, pseudogene Mus musculus 27-30 10523021-6 1999 Changes in plasma leptin during the clamp stages were correlated with abdominal dialysate glycerol concentrations (r = -0.44; P < 0.05), but not femoral dialysate glycerol concentrations (r = -0.15), the rate of appearance of glycerol in plasma (r = 0.005), or plasma insulin levels (r = 0.16). Glycerol 90-98 leptin Homo sapiens 18-24 10589445-5 1999 In rats given 15% glycerol/15% fructose solution, postheparin plasma LPL activity declined to two third of normal rats, whereas ginseng saponins reversed it to normal levels. Glycerol 18-26 lipoprotein lipase Rattus norvegicus 69-72 10504238-3 1999 Free dimethylbenzimidazole axial base-on cob(II)alamin was formed by photolysis of the corresponding adenosylcobalamin and cryotrapped in glycerol-aqueous glass. Glycerol 138-146 metabolism of cobalamin associated B Homo sapiens 41-44 10556579-2 1999 The yeast STE11 is an integral component of two MAP kinase cascades: the mating pheromone pathway and the HOG (high osmolarity glycerol response) pathway. Glycerol 127-135 mitogen-activated protein kinase kinase kinase STE11 Saccharomyces cerevisiae S288C 10-15 10556579-6 1999 Enhanced glycerol production, observed in non-stressed cells expressing ATMEKK1 is the probable cause of yeast survival. Glycerol 9-17 MAPK/ERK kinase kinase 1 Arabidopsis thaliana 72-79 10528916-0 1999 Restoration by glycerol of p53-dependent apoptosis in cells bearing the mutant p53 gene. Glycerol 15-23 transformation related protein 53, pseudogene Mus musculus 79-82 10528916-1 1999 PURPOSE: Effective heat-induced cell death in cultured cells bearing a mutant p53 (mp53) gene was sought by glycerol treatment which led to conformational change from mp53 to wild-type p53 (wtp53) in p53-null murine fibroblasts transfected with mp53. Glycerol 108-116 transformation related protein 53, pseudogene Mus musculus 78-81 10528916-1 1999 PURPOSE: Effective heat-induced cell death in cultured cells bearing a mutant p53 (mp53) gene was sought by glycerol treatment which led to conformational change from mp53 to wild-type p53 (wtp53) in p53-null murine fibroblasts transfected with mp53. Glycerol 108-116 transformation related protein 53, pseudogene Mus musculus 84-87 10528916-1 1999 PURPOSE: Effective heat-induced cell death in cultured cells bearing a mutant p53 (mp53) gene was sought by glycerol treatment which led to conformational change from mp53 to wild-type p53 (wtp53) in p53-null murine fibroblasts transfected with mp53. Glycerol 108-116 transformation related protein 53, pseudogene Mus musculus 84-87 10492461-7 1999 The coincidence of a short-term surge of plasma insulin with marked transient decreases in plasma FFA, glycerol, and beta-hydroxybutyrate as well as with the transition from hyper- to hypoglycemia indicates that insulin plays a role in some of the metabolic responses to LPS. Glycerol 103-111 insulin Homo sapiens 48-55 10492461-7 1999 The coincidence of a short-term surge of plasma insulin with marked transient decreases in plasma FFA, glycerol, and beta-hydroxybutyrate as well as with the transition from hyper- to hypoglycemia indicates that insulin plays a role in some of the metabolic responses to LPS. Glycerol 103-111 insulin Homo sapiens 212-219 10482659-4 1999 Sorbitol and mannitol provided some protection, but less than that generated by a similar concentration of glycerol generated by glycerol-3-P dehydrogenase (GPD1). Glycerol 107-115 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 157-161 10449419-9 1999 Finally, we show that both tri-snRNPs and the U2 snRNP are co-precipitated with protein A-tagged versions of Snu23p, Snu66p and Spp381p from extracts fractionated by glycerol gradient centrifugation. Glycerol 166-174 U4/U6-U5 snRNP complex subunit SNU23 Saccharomyces cerevisiae S288C 109-115 10449419-9 1999 Finally, we show that both tri-snRNPs and the U2 snRNP are co-precipitated with protein A-tagged versions of Snu23p, Snu66p and Spp381p from extracts fractionated by glycerol gradient centrifugation. Glycerol 166-174 U4/U6-U5 snRNP complex subunit SPP381 Saccharomyces cerevisiae S288C 128-135 10444428-5 1999 Glycerol production in response to dibutyryl cAMP, a direct stimulant of hormone-sensitive lipase (HSL) via protein kinase A (PKA), was significantly attenuated. Glycerol 0-8 lipase E, hormone sensitive type Rattus norvegicus 73-97 10444428-5 1999 Glycerol production in response to dibutyryl cAMP, a direct stimulant of hormone-sensitive lipase (HSL) via protein kinase A (PKA), was significantly attenuated. Glycerol 0-8 lipase E, hormone sensitive type Rattus norvegicus 99-102 10444428-5 1999 Glycerol production in response to dibutyryl cAMP, a direct stimulant of hormone-sensitive lipase (HSL) via protein kinase A (PKA), was significantly attenuated. Glycerol 0-8 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 108-124 10444428-5 1999 Glycerol production in response to dibutyryl cAMP, a direct stimulant of hormone-sensitive lipase (HSL) via protein kinase A (PKA), was significantly attenuated. Glycerol 0-8 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 126-129 10447592-9 1999 AAC1 introduced in K. lactis was transcribed to a high level consistent with normal growth on glycerol being restored in the transformed mutant. Glycerol 94-102 ADP/ATP carrier protein AAC1 Saccharomyces cerevisiae S288C 0-4 10404120-6 1999 Use of glycerol in place of NaCl to create hyperosmotic conditions stimulated induction of hsp70 in branchial lamellae. Glycerol 7-15 heat shock protein 70 Salmo salar 91-96 10441663-1 1999 MIP has been hypothesized to be a gap junction protein, a membrane ion channel, a membrane water channel and a facilitator of glycerol transport and metabolism. Glycerol 126-134 major intrinsic protein of lens fiber Mus musculus 0-3 10409737-5 1999 hot1 single mutants are specifically compromised in the transient induction of GPD1 and GPP2, which encode enzymes involved in glycerol biosynthesis, and exhibit delayed glycerol accumulation after stress exposure. Glycerol 127-135 Hot1p Saccharomyces cerevisiae S288C 0-4 10409737-5 1999 hot1 single mutants are specifically compromised in the transient induction of GPD1 and GPP2, which encode enzymes involved in glycerol biosynthesis, and exhibit delayed glycerol accumulation after stress exposure. Glycerol 127-135 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 79-83 10409737-5 1999 hot1 single mutants are specifically compromised in the transient induction of GPD1 and GPP2, which encode enzymes involved in glycerol biosynthesis, and exhibit delayed glycerol accumulation after stress exposure. Glycerol 127-135 glycerol-1-phosphatase HOR2 Saccharomyces cerevisiae S288C 88-92 10409737-5 1999 hot1 single mutants are specifically compromised in the transient induction of GPD1 and GPP2, which encode enzymes involved in glycerol biosynthesis, and exhibit delayed glycerol accumulation after stress exposure. Glycerol 170-178 Hot1p Saccharomyces cerevisiae S288C 0-4 12555570-1 1999 The response of the yeast Saccharomyces cerevisiae to osmotic stress is to synthesis and accumulate the glycerol in order to increase the internal osmolarity and this response is controlled by the high-osmolarity glycerol (HOG) response pathway, whose important target gene is GPD1. Glycerol 104-112 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 277-281 12555570-1 1999 The response of the yeast Saccharomyces cerevisiae to osmotic stress is to synthesis and accumulate the glycerol in order to increase the internal osmolarity and this response is controlled by the high-osmolarity glycerol (HOG) response pathway, whose important target gene is GPD1. Glycerol 213-221 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 277-281 12555570-2 1999 The increase of the activity of glycerol-3-phosphate dehydrogenase by over-expression of GPD1 gene can increase the glycerol yield greatly. Glycerol 32-40 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 89-93 10419471-0 1999 Transport of water and glycerol in aquaporin 3 is gated by H(+). Glycerol 23-31 aquaporin 3 (Gill blood group) S homeolog Xenopus laevis 35-46 10419471-4 1999 For AQP3 the glycerol permeability P(Gl), obtained from [(14)C]glycerol uptake, was abolished at acid pH values with a pK of 6.1 and a Hill coefficient of 6. Glycerol 13-21 aquaporin 3 (Gill blood group) S homeolog Xenopus laevis 4-8 10419471-4 1999 For AQP3 the glycerol permeability P(Gl), obtained from [(14)C]glycerol uptake, was abolished at acid pH values with a pK of 6.1 and a Hill coefficient of 6. Glycerol 63-71 aquaporin 3 (Gill blood group) S homeolog Xenopus laevis 4-8 10419471-5 1999 Consequently, AQP3 acts as a glycerol and water channel at physiological pH, but predominantly as a glycerol channel at pH values around 6.1. Glycerol 29-37 aquaporin 3 (Gill blood group) S homeolog Xenopus laevis 14-18 10419471-8 1999 For AQP3, water and glycerol interacted by competing for titratable site(s): sigma(Gl) was 0.15 at neutral pH but doubled at pH 6.4. Glycerol 20-28 aquaporin 3 (Gill blood group) S homeolog Xenopus laevis 4-8 10492021-0 1999 Formation of a molten-globule-like state of cytochrome c induced by high concentrations of glycerol. Glycerol 91-99 cytochrome c, somatic Homo sapiens 44-56 10492021-1 1999 The effect of glycerol on the structure of cytochrome c was investigated by circular dichroism, absorbance and EPR spectroscopy. Glycerol 14-22 cytochrome c, somatic Homo sapiens 43-55 10400607-2 1999 We also overexpressed Fps1p, the putative glycerol facilitator in S. cerevisiae, in secretory vesicles but observed no effect on water, glycerol, formamide, or urea permeations. Glycerol 42-50 Fps1p Saccharomyces cerevisiae S288C 22-27 10400607-3 1999 However, spheroplasts prepared from the strain overexpressing Fps1p showed enhanced glycerol uptake, suggesting that Fps1p becomes active only upon insertion in the plasma membrane. Glycerol 84-92 Fps1p Saccharomyces cerevisiae S288C 62-67 10400607-3 1999 However, spheroplasts prepared from the strain overexpressing Fps1p showed enhanced glycerol uptake, suggesting that Fps1p becomes active only upon insertion in the plasma membrane. Glycerol 84-92 Fps1p Saccharomyces cerevisiae S288C 117-122 10397774-5 1999 This interaction relieves a negative activity of the Ste11p N terminus, and removal of this negative function is required for Ste11p function in the high-osmolarity glycerol (HOG) pathway. Glycerol 165-173 mitogen-activated protein kinase kinase kinase STE11 Saccharomyces cerevisiae S288C 53-59 10397774-5 1999 This interaction relieves a negative activity of the Ste11p N terminus, and removal of this negative function is required for Ste11p function in the high-osmolarity glycerol (HOG) pathway. Glycerol 165-173 mitogen-activated protein kinase kinase kinase STE11 Saccharomyces cerevisiae S288C 126-132 10364187-3 1999 Whereas NE increased both FFA and glycerol release from adipocytes of +/+ rats, leptin increased glycerol release in +/+ adipocytes without a parallel increase in FFA release. Glycerol 97-105 leptin Rattus norvegicus 80-86 10393252-2 1999 When MF1 is stored at room temperature in 50% glycerol and 100 mM Tris-HCl (pH 7.3) after slow passage through a Sephadex column, the tightly bound ATP is slowly dephosphorylated to ADP which is subsequently released, without effect on activity. Glycerol 47-55 flap structure-specific endonuclease 1 Homo sapiens 6-9 10364187-7 1999 We conclude that in normal adipocytes leptin directly decreases FAS expression, increases PPARalpha and the enzymes of FFA oxidation, and stimulates a novel form of lipolysis in which glycerol is released without a proportional release of FFA. Glycerol 184-192 leptin Rattus norvegicus 38-44 10364471-0 1999 X-Ray structure of glycerol kinase complexed with an ATP analog implies a novel mechanism for the ATP-dependent glycerol phosphorylation by glycerol kinase. Glycerol 19-27 glycerol kinase Homo sapiens 140-155 10501514-0 1999 Glycerol-induced seizure: involvement of IL-1beta and glutamate. Glycerol 0-8 interleukin 1 beta Mus musculus 41-49 10387000-2 1999 The equilibrium concentration of metarhodopsin II (MII), the conformation of photoactivated rhodopsin, which binds and activates transducin, was increased by glycerol, sucrose, and stachyose in a manner which was linear with osmolality. Glycerol 158-166 rhodopsin Homo sapiens 37-46 10347187-4 1999 Glycerol gradient centrifugation indicated that endogenous Nek2 is present in HeLa cells as a salt-resistant 6 S complex, the predicted size of a Nek2 homodimer. Glycerol 0-8 NIMA related kinase 2 Homo sapiens 59-63 10385064-2 1999 Cold single-strand conformation polymorphism (SSCP) with 12% glycerol identified the G727T mutation in the glucose-6-phosphatase (G6Pase) gene, which has been reported to be the most common mutation in Japanese GSD1a patients. Glycerol 61-69 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 107-128 10385064-2 1999 Cold single-strand conformation polymorphism (SSCP) with 12% glycerol identified the G727T mutation in the glucose-6-phosphatase (G6Pase) gene, which has been reported to be the most common mutation in Japanese GSD1a patients. Glycerol 61-69 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 130-136 10385064-2 1999 Cold single-strand conformation polymorphism (SSCP) with 12% glycerol identified the G727T mutation in the glucose-6-phosphatase (G6Pase) gene, which has been reported to be the most common mutation in Japanese GSD1a patients. Glycerol 61-69 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 211-216 10417707-0 1999 The Nicotiana tabacum plasma membrane aquaporin NtAQP1 is mercury-insensitive and permeable for glycerol. Glycerol 96-104 probable aquaporin TIP1-1 Nicotiana tabacum 48-54 10417707-6 1999 Functional expression in Xenopus oocytes revealed that NtAQP1 can mediate glycerol transport in addition to water flow. Glycerol 74-82 probable aquaporin TIP1-1 Nicotiana tabacum 55-61 10346906-3 1999 Laser excitation of the 1:1 Ru-39-Cc-CcP compound I complex at low ionic strength results in rapid electron transfer from RuII to heme c FeIII, followed by electron transfer from heme c FeII to the Trp-191 indolyl radical cation with a rate constant keta of 2 x 10(6) s-1 at 20 degrees C. keta is not changed by increasing the viscosity up to 40 cP with glycerol and is independent of temperature. Glycerol 354-362 HCC Homo sapiens 34-36 10320809-7 1999 In the sn-1 to -1(3) transfer, the sn-1 acyl residue of 1-acyl-sn-glycero-3-phosphocholine was transferred to the sn-1(3) positions of glycerol and 2-acyl-sn-glycerol, producing 1(3)-acyl-sn-glycerol and 1,2-diacyl-sn-glycerol, respectively. Glycerol 135-143 heterogeneous nuclear ribonucleoprotein U Rattus norvegicus 7-17 10364471-1 1999 Glycerol kinase (GK) catalyzes the Mg-ATP-dependent phosphorylation of glycerol which yields glycerol 3-phosphate. Glycerol 71-79 glycerol kinase Homo sapiens 0-15 10364471-1 1999 Glycerol kinase (GK) catalyzes the Mg-ATP-dependent phosphorylation of glycerol which yields glycerol 3-phosphate. Glycerol 71-79 glycerol kinase Homo sapiens 17-19 10364471-2 1999 The 2.8 A new crystal structure of GK complexed with an ATP analog revealed an unexpected position of the gamma-phosphoryl group, which was 7.2 A distant from the 3-hydroxyl group of glycerol, 5.5 A away from the 3-phosphate of the product (glycerol 3-phosphate) and is stabilized by a beta-hairpin structure. Glycerol 183-191 glycerol kinase Homo sapiens 35-37 10364471-3 1999 Based on the presented crystal structure and the previously determined structures of GK product complexes, we propose a 3-D model of a nucleophilic in-line transfer mechanism for the ATP-dependent phosphorylation of glycerol by GK. Glycerol 216-224 glycerol kinase Homo sapiens 85-87 10233036-3 1999 Although body weight was comparably reduced (-8%) and plasma glycerol was comparably increased (142 and 17%, respectively) in leptin-treated and pair-fed animals relative to controls, increases in plasma fatty acids and ketones were only detected (132 and 234%, respectively) in pair-fed rats. Glycerol 61-69 leptin Rattus norvegicus 126-132 10233086-0 1999 Effect of glycerol on the interactions and solubility of bovine pancreatic trypsin inhibitor. Glycerol 10-18 trophoblast Kunitz domain protein 1 Bos taurus 75-92 10219083-1 1999 Using proliferating cell nuclear antigen affinity chroma-tography and glycerol gradient centrifugation of partially purified fractions from mouse FM3A cells we have been able to isolate novel complexes of DNA polymerase delta and DNA ligase 1 containing clearly defined subunit compositions. Glycerol 70-78 ligase I, DNA, ATP-dependent Mus musculus 230-242 10233086-2 1999 Here we investigate the effect of glycerol and ionic strength on the solubility and strength of interactions of the bovine pancreatic trypsin inhibitor. Glycerol 34-42 trophoblast Kunitz domain protein 1 Bos taurus 134-151 10233086-4 1999 These changes are mirrored in bovine pancreatic trypsin inhibitor solubility where the typical salting out behavior for NaCl is observed with higher solubility found in buffers containing glycerol. Glycerol 188-196 trophoblast Kunitz domain protein 1 Bos taurus 48-65 10328873-5 1999 Tumour necrosis factor alpha and interleukin 6 applied alone stimulated lipolysis, but combined with interleukin 4, they suppressed glycerol release, especially in perinodal adipocytes, thereby creating large within-depot differences. Glycerol 132-140 interleukin-6 Cavia porcellus 33-46 10328873-5 1999 Tumour necrosis factor alpha and interleukin 6 applied alone stimulated lipolysis, but combined with interleukin 4, they suppressed glycerol release, especially in perinodal adipocytes, thereby creating large within-depot differences. Glycerol 132-140 interleukin-4 Cavia porcellus 101-114 10224250-5 1999 Null and nonsense idh2 mutants grow poorly on glycerol, but growth can be enhanced by extragenic mutations, termed glycerol suppressors, in the CIT1 gene encoding the TCA cycle citrate synthase and in other genes of oxidative metabolism. Glycerol 46-54 isocitrate dehydrogenase (NAD(+)) IDH2 Saccharomyces cerevisiae S288C 18-22 10224250-5 1999 Null and nonsense idh2 mutants grow poorly on glycerol, but growth can be enhanced by extragenic mutations, termed glycerol suppressors, in the CIT1 gene encoding the TCA cycle citrate synthase and in other genes of oxidative metabolism. Glycerol 115-123 citrate (Si)-synthase CIT1 Saccharomyces cerevisiae S288C 144-148 10224250-7 1999 Mutations in 7 TCA cycle genes were capable of functioning as suppressors for growth of idh2 mutants on glycerol. Glycerol 104-112 isocitrate dehydrogenase (NAD(+)) IDH2 Saccharomyces cerevisiae S288C 88-92 10224250-8 1999 The only other TCA cycle gene to display the glycerol-suppressor-accumulation phenotype was IDH1, which encodes the companion Idh1p subunit of NAD-IDH. Glycerol 45-53 isocitrate dehydrogenase (NAD(+)) IDH1 Saccharomyces cerevisiae S288C 92-96 10224167-7 1999 The glycerol release from isproterenol-stimulated ALBP/aP2 null fat cells was similarly reduced by approximately 35%. Glycerol 4-12 fatty acid binding protein 4, adipocyte Mus musculus 50-58 10222385-3 1999 Force-feeding a fructose and sucrose diet, (40% energy as fructose or sucrose) gave rise to parallel increases in the transcripts of SI and intestinal hexose transporters (SGLT1, GLUT5, and GLUT2) within 12 h. Force-feeding a glycerol-containing diet also caused an enhancement of SI, SGLT1, and GLUT2 mRNA levels. Glycerol 226-234 solute carrier family 5 member 1 Rattus norvegicus 172-177 10223447-0 1999 Trigeminal nerve peripheral branch phenol/glycerol injections for tic douloureux. Glycerol 42-50 pleckstrin and Sec7 domain containing 4 Homo sapiens 66-69 10220331-5 1999 Assembly studies in the presence of glycerol and Mg2+ show that one of the fractions, that contains mainly the tyrosinated form of alpha1/2, assembled poorly, while the nontyrosinated form assembled normally. Glycerol 36-44 adrenoceptor alpha 1D Homo sapiens 131-139 10220351-5 1999 We have assessed the minimal ionic strength and detergent and glycerol concentrations required for maximal proteolytic activity and stability of the purified NS3-NS4A complex. Glycerol 62-70 KRAS proto-oncogene, GTPase Homo sapiens 158-161 10206998-5 1999 Glycerol uptake and antisense studies suggest CFTR-dependent regulation of aquaporin 3 (AQP3) water channels in airway epithelial cells. Glycerol 0-8 CF transmembrane conductance regulator Homo sapiens 46-50 11220296-5 1999 RESULTS: Using the low-dose insulin infusion there were significant correlations between measures of insulin sensitivity for glucose metabolism and those for NEFA (r = 0.82, p < 0.01) and glycerol (r = 0.73, p < 0.01). Glycerol 191-199 insulin Homo sapiens 28-35 10213628-4 1999 The extent of glycerol-induced stabilization varied in an HCV strain-dependent way with at least one determinant mapping to an NS3-NS4A interaction site. Glycerol 14-22 KRAS proto-oncogene, GTPase Homo sapiens 127-130 10206998-5 1999 Glycerol uptake and antisense studies suggest CFTR-dependent regulation of aquaporin 3 (AQP3) water channels in airway epithelial cells. Glycerol 0-8 aquaporin 3 (Gill blood group) Homo sapiens 75-86 10206998-5 1999 Glycerol uptake and antisense studies suggest CFTR-dependent regulation of aquaporin 3 (AQP3) water channels in airway epithelial cells. Glycerol 0-8 aquaporin 3 (Gill blood group) Homo sapiens 88-92 10191086-9 1999 The chemical chaperone glycerol produced a redistribution of Aqp2-T126M from ER to plasma membrane/endosomes. Glycerol 23-31 aquaporin 2 Mus musculus 61-65 10198019-1 1999 The function of the extracellular domain (ECD) of Sln1p, a plasma membrane two-transmembrane domain (TMD) sensor of the high-osmolarity glycerol (HOG) response pathway, has been studied in the yeast Saccharomyces cerevisiae. Glycerol 136-144 histidine kinase Saccharomyces cerevisiae S288C 50-55 10090282-2 1999 Here we report the high-resolution crystal structures of free UDG from Escherichia coli strain B (1.60 A), its complex with uracil (1.50 A), and a second active-site complex with glycerol (1.43 A). Glycerol 179-187 uracil DNA glycosylase Homo sapiens 62-65 10190503-0 1999 Restoration of mutant TP53 to normal TP53 function by glycerol as a chemical chaperone. Glycerol 54-62 tumor protein p53 Homo sapiens 22-26 10190503-0 1999 Restoration of mutant TP53 to normal TP53 function by glycerol as a chemical chaperone. Glycerol 54-62 tumor protein p53 Homo sapiens 37-41 10190503-5 1999 We examined whether glycerol can act as a chemical chaperone to correct the mutant TP53 conformation. Glycerol 20-28 tumor protein p53 Homo sapiens 83-87 10190503-7 1999 In contrast, A-172/mp53/ 143 cells showed CDKN1A expression when they were heated in the presence of glycerol at 0.6 or 1.2 M, which was similar to the response of the parental and neo vector-transfected control cells. Glycerol 101-109 cyclin dependent kinase inhibitor 1A Homo sapiens 42-48 10190503-9 1999 These cells showed similar CDKN1A expression when heated in the presence of glycerol at 0.6 or 1.2 M. These results suggest that glycerol is effective in restoring several TP53 mutants to normal TP53 function, leading to normal CDKN1A expression after heat stress. Glycerol 129-137 tumor protein p53 Homo sapiens 172-176 10190503-9 1999 These cells showed similar CDKN1A expression when heated in the presence of glycerol at 0.6 or 1.2 M. These results suggest that glycerol is effective in restoring several TP53 mutants to normal TP53 function, leading to normal CDKN1A expression after heat stress. Glycerol 129-137 tumor protein p53 Homo sapiens 195-199 10190503-9 1999 These cells showed similar CDKN1A expression when heated in the presence of glycerol at 0.6 or 1.2 M. These results suggest that glycerol is effective in restoring several TP53 mutants to normal TP53 function, leading to normal CDKN1A expression after heat stress. Glycerol 129-137 cyclin dependent kinase inhibitor 1A Homo sapiens 228-234 10096077-0 1999 Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation. Glycerol 69-77 Fps1p Saccharomyces cerevisiae S288C 0-5 10037777-4 1999 Without adenosine deaminase, the rate of glycerol release was 2-3-fold higher in the TNFalpha-treated cells, but with adenosine deaminase lipolysis increased in the controls to approximately that in the TNFalpha-treated cells. Glycerol 41-49 tumor necrosis factor Homo sapiens 85-93 10024533-6 1999 Glycerol gradient centrifugation experiments indicated that native EEA1 had the same hydrodynamic properties as the approximately 350-kDa crosslinked complex. Glycerol 0-8 early endosome antigen 1 Homo sapiens 67-71 10191831-7 1999 This is in addition to the presence of substrates, such as glycerol and FFA, which are stored and released by fat cells and are known to have a major role in hepatic and peripheral glucose metabolism. Glycerol 59-67 FAT atypical cadherin 1 Homo sapiens 110-113 10102376-3 1999 Screening of two S. cerevisiae cDNA libraries led to the identification of CBT1 as a gene which, if overexpressed simultaneously with CDC14, results in the rescue of the dbJ2-2 mutation at restrictive temperature on galactose-based medium, as well as on media containing non-fermentable carbon sources such as glycerol, lactate and acetate. Glycerol 310-318 Cbt1p Saccharomyces cerevisiae S288C 75-79 10102376-3 1999 Screening of two S. cerevisiae cDNA libraries led to the identification of CBT1 as a gene which, if overexpressed simultaneously with CDC14, results in the rescue of the dbJ2-2 mutation at restrictive temperature on galactose-based medium, as well as on media containing non-fermentable carbon sources such as glycerol, lactate and acetate. Glycerol 310-318 phosphoprotein phosphatase CDC14 Saccharomyces cerevisiae S288C 134-139 10102376-5 1999 On the other hand, the ts defects of ccr4delta and caf1delta mutants on glycerol medium at 37 degrees C (Ccr4 and Caf1/Pop2 are two other members of the CCR4 complex) could not be complemented by simultaneous overexpression of CBT1 and CDC14. Glycerol 72-80 CCR4-NOT core exoribonuclease subunit CCR4 Saccharomyces cerevisiae S288C 105-109 10102376-5 1999 On the other hand, the ts defects of ccr4delta and caf1delta mutants on glycerol medium at 37 degrees C (Ccr4 and Caf1/Pop2 are two other members of the CCR4 complex) could not be complemented by simultaneous overexpression of CBT1 and CDC14. Glycerol 72-80 CCR4-NOT core DEDD family RNase subunit POP2 Saccharomyces cerevisiae S288C 119-123 10102376-5 1999 On the other hand, the ts defects of ccr4delta and caf1delta mutants on glycerol medium at 37 degrees C (Ccr4 and Caf1/Pop2 are two other members of the CCR4 complex) could not be complemented by simultaneous overexpression of CBT1 and CDC14. Glycerol 72-80 CCR4-NOT core exoribonuclease subunit CCR4 Saccharomyces cerevisiae S288C 153-157 10217506-6 1999 Deletion of HOG1, which encodes the terminal protein kinase of the high osmolarity glycerol (HOG) response pathway, led to an even longer lag phase and drastically lower basal and induced GPD1 mRNA levels. Glycerol 83-91 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 12-16 10102470-2 1999 Non-ionic detergents, includine Triton X-100, reduced the inhibitory activity of PAI-1 more than 20-fold at 0 degrees C, but less than 2-fold at 37 degrees C, while glycerol partly prevented the detergent-induced activity-loss at 0 degrees C. The activity-loss was associated with an increase in PAI-1 substrate behaviour. Glycerol 165-173 serpin family E member 1 Homo sapiens 81-86 10102470-2 1999 Non-ionic detergents, includine Triton X-100, reduced the inhibitory activity of PAI-1 more than 20-fold at 0 degrees C, but less than 2-fold at 37 degrees C, while glycerol partly prevented the detergent-induced activity-loss at 0 degrees C. The activity-loss was associated with an increase in PAI-1 substrate behaviour. Glycerol 165-173 serpin family E member 1 Homo sapiens 296-301 10049773-7 1999 Leptin changes in lean rats are concomitant with the peak of NEFA and glycerol release from adipose tissue rather than with the reduction of plasma insulin. Glycerol 70-78 leptin Rattus norvegicus 0-6 9990012-0 1999 Structure, thermostability, and conformational flexibility of hen egg-white lysozyme dissolved in glycerol. Glycerol 98-106 lysozyme Homo sapiens 76-84 9990012-1 1999 Hen egg-white lysozyme dissolved in glycerol containing 1% water was studied by using CD and amide proton exchange monitored by two-dimensional 1H NMR. Glycerol 36-44 lysozyme Homo sapiens 14-22 9990012-2 1999 The far- and near-UV CD spectra of the protein showed that the secondary and tertiary structures of lysozyme in glycerol were similar to those in water. Glycerol 112-120 lysozyme Homo sapiens 100-108 9990012-3 1999 Thermal melting of lysozyme in glycerol followed by CD spectral changes indicated unfolding of the tertiary structure with a Tm of 76.0 +/- 0.2 degreesC and no appreciable loss of the secondary structure up to 85 degreesC. Glycerol 31-39 lysozyme Homo sapiens 19-27 9990012-6 1999 The results point to a highly ordered, native-like structure of lysozyme in glycerol, with the stability exceeding that in water. Glycerol 76-84 lysozyme Homo sapiens 64-72 9950781-9 1999 During glucose infusion, there was apparently a relative increase in the fraction of glycerol derived from the action of lipoprotein lipase and an increase in reesterification in situ. Glycerol 85-93 lipoprotein lipase Homo sapiens 121-139 9950787-4 1999 The percent increase in glycerol Ra correlated closely with the percent decline in plasma insulin in both groups (r2 = 0.85; P < 0.05). Glycerol 24-32 insulin Homo sapiens 90-97 10064095-7 1999 Reduction of adipose tissue mass and suppression of leptin by IGF I appear to be due to reduced circulating insulin leading to enhanced fat mobilization and NEFA oxidation as well as to increased gluconeogenesis from glycerol. Glycerol 217-225 leptin Rattus norvegicus 52-58 10064095-7 1999 Reduction of adipose tissue mass and suppression of leptin by IGF I appear to be due to reduced circulating insulin leading to enhanced fat mobilization and NEFA oxidation as well as to increased gluconeogenesis from glycerol. Glycerol 217-225 insulin-like growth factor 1 Rattus norvegicus 62-67 10338683-6 1999 RESULTS: Plasma leptin was correlated to NEFA (r = 0.28) and glycerol (r = 0.48) concentrations. Glycerol 61-69 leptin Homo sapiens 16-22 10338683-8 1999 In multiple regression %fat, body mass index, glycerol, and gender, but not fat mass, age or NEFA contributed independently to the variation in log plasma leptin. Glycerol 46-54 leptin Homo sapiens 155-161 10338683-9 1999 Log plasma leptin was higher in women than in men for a given glycerol concentration. Glycerol 62-70 leptin Homo sapiens 11-17 10048586-7 1999 Induction of PKCepsilon expression by galactose in cells transformed with pYECepsilon increased Ca++ uptake by the cells approximately 5-fold and resulted in a dramatic inhibition of cell growth in glycerol. Glycerol 198-206 protein kinase C, epsilon Mus musculus 13-23 10048586-10 1999 Visualization of the cells by phase contrast microscopy indicated that murine PKCepsilon expression in the presence of glycerol resulted in a significant increase in the number of yeast cells exhibiting very small buds. Glycerol 119-127 protein kinase C, epsilon Mus musculus 78-88 10096077-2 1999 Here, we demonstrate that yeast cells control glycerol accumulation in part via a regulated, Fps1p-mediated export of glycerol. Glycerol 46-54 Fps1p Saccharomyces cerevisiae S288C 93-98 10096077-2 1999 Here, we demonstrate that yeast cells control glycerol accumulation in part via a regulated, Fps1p-mediated export of glycerol. Glycerol 118-126 Fps1p Saccharomyces cerevisiae S288C 93-98 10096077-3 1999 Fps1p is a member of the MIP family of channel proteins most closely related to the bacterial glycerol facilitators. Glycerol 94-102 Fps1p Saccharomyces cerevisiae S288C 0-5 10096077-5 1999 The physiological role of Fps1p appears to be glycerol export rather than uptake. Glycerol 46-54 Fps1p Saccharomyces cerevisiae S288C 26-31 10096077-9 1999 Mutants lacking the unique hydrophilic N-terminal domain of Fps1p, or certain parts thereof, fail to reduce the glycerol transport rate after a hyperosmotic shock. Glycerol 112-120 Fps1p Saccharomyces cerevisiae S288C 60-65 10078333-4 1999 In view of an increase in 14CO2 fixation and elevation of both cytosolic and mitochondrial NADH/NAD+ ratios, the activation of glucose formation from alanine upon the addition of glycerol and octanoate is likely due to (i) stimulation of pyruvate carboxylation, (ii) increased availability of NADH for glyceraldehyde-3-phosphate dehydrogenase and (iii) elevation of mitochondrial redox state causing a diminished provision of ammonium for glutamine synthesis. Glycerol 179-187 glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus 302-342 9920737-6 1999 After the glycerol injection JNK was rapidly and transiently activated at about 4 h, while the activation of ERK was gradually increased and the levels were sustained at least to 24 h. Next, we examined the expression of cell-cycle related proteins after the glycerol injection using Western blot analysis. Glycerol 10-18 mitogen-activated protein kinase 8 Rattus norvegicus 29-32 9920741-6 1999 EXAFS spectra collected on full-length xXPA in frozen (77 K) 15% glycerol aqueous solution unequivocally show that the zinc atom is coordinated to four sulfur atoms with an average Zn--S bond length of 2.33 +/- 0.02 A. Glycerol 65-73 xeroderma pigmentosum, complementation group A L homeolog Xenopus laevis 39-43 10872456-8 1999 Multifunctional aquaglyceroporins AQP3, AQP7, and AQP9 are permeated by water, glycerol, and some other solutes. Glycerol 79-87 aquaporin 3 (Gill blood group) Homo sapiens 34-38 9886953-18 1999 During insulin infusion, systemic gluconeogenesis from glycerol decreased from 0.67 +/- 0.05 to 0.18 +/- 0.02 (LO) and from 0.60 +/- 0.04 to 0.20 +/- 0.02 (HI) micromol. Glycerol 55-63 insulin Homo sapiens 7-14 9872772-1 1999 Overexpression of the GPD1 gene, encoding a glycerol-3-phosphate dehydrogenase, resulted in a 1.5- to 2.5-fold increase in glycerol production and a slight decrease in ethanol formation under conditions simulating wine fermentation. Glycerol 124-132 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 23-27 9872772-1 1999 Overexpression of the GPD1 gene, encoding a glycerol-3-phosphate dehydrogenase, resulted in a 1.5- to 2.5-fold increase in glycerol production and a slight decrease in ethanol formation under conditions simulating wine fermentation. Glycerol 124-132 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 45-79 9872772-4 1999 Wine strains overproducing glycerol at moderate levels (12 to 18 g/liter) reduced acetoin almost completely to 2,3-butanediol. A lower biomass concentration was attained by GPD1-overexpressing strains, probably due to high acetaldehyde production during the growth phase. Glycerol 28-36 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 174-178 10325757-0 1999 Insulin induced hypoglycaemia: comparison of glucose and glycerol concentrations in plasma and microdialysate from subcutaneous adipose tissue. Glycerol 57-65 insulin Homo sapiens 0-7 10872456-8 1999 Multifunctional aquaglyceroporins AQP3, AQP7, and AQP9 are permeated by water, glycerol, and some other solutes. Glycerol 79-87 aquaporin 7 Homo sapiens 40-44 10872456-8 1999 Multifunctional aquaglyceroporins AQP3, AQP7, and AQP9 are permeated by water, glycerol, and some other solutes. Glycerol 79-87 aquaporin 9 Homo sapiens 50-54 9886851-6 1999 GIP stimulated glycerol release with an EC50 of 3.28 +/- 0.63 nM. Glycerol 15-23 gastric inhibitory polypeptide Mus musculus 0-3 9886851-8 1999 The adenylyl cyclase inhibitor MDL 12330A (10(-4) M) inhibited GIP-induced glycerol production by >90%, and reduced cAMP responses to basal. Glycerol 75-83 gastric inhibitory polypeptide Mus musculus 63-66 9886851-9 1999 Preincubation of 3T3-L1 cells with insulin inhibited glycerol responses to GIP, and the inhibitory effect of insulin was blocked by the phosphatidylinositol 3"-kinase inhibitor, wortmannin. Glycerol 53-61 gastric inhibitory polypeptide Mus musculus 75-78 9886851-10 1999 It is concluded that GIP stimulates glycerol release in 3T3-L1 cells primarily via stimulation of cAMP production, and that insulin antagonizes GIP-induced lipolysis in a wortmannin-sensitive fashion. Glycerol 36-44 gastric inhibitory polypeptide Mus musculus 21-24 9867851-0 1999 Intracellular glycerol levels modulate the activity of Sln1p, a Saccharomyces cerevisiae two-component regulator. Glycerol 14-22 histidine kinase Saccharomyces cerevisiae S288C 55-60 9867864-17 1999 The migration of solubilized Golgi GCS in glycerol gradients was also consistent with a predominantly oligomeric organization of GCS. Glycerol 42-50 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 35-38 9882653-2 1999 The SLN1-YPD1-SSK1 phosphorelay regulates a downstream mitogen-activated protein kinase cascade which ultimately controls the concentration of glycerol within the cell under hyperosmotic stress conditions. Glycerol 143-151 histidine kinase Saccharomyces cerevisiae S288C 4-8 9882653-2 1999 The SLN1-YPD1-SSK1 phosphorelay regulates a downstream mitogen-activated protein kinase cascade which ultimately controls the concentration of glycerol within the cell under hyperosmotic stress conditions. Glycerol 143-151 Ypd1p Saccharomyces cerevisiae S288C 9-13 9882653-2 1999 The SLN1-YPD1-SSK1 phosphorelay regulates a downstream mitogen-activated protein kinase cascade which ultimately controls the concentration of glycerol within the cell under hyperosmotic stress conditions. Glycerol 143-151 mitogen-activated protein kinase kinase kinase SSK1 Saccharomyces cerevisiae S288C 14-18 9916137-6 1999 Insulin stimulation, during the glycerol infusion, resulted in a fourfold increase in PI 3-kinase activity over basal that was abolished during the lipid infusion. Glycerol 32-40 insulin Homo sapiens 0-7 9915890-7 1999 Addition of ST, in the absence or presence of insulin, also increased the accumulation of glycerol in the medium during culture of neonatal and growing pig adipose tissue. Glycerol 90-98 somatotropin Sus scrofa 12-14 9880329-11 1999 We show that Pde1 is rapidly phosphorylated in vivo upon addition of glucose to glycerol-grown cells, and this activation is absent in the Pde1(ala252) mutant. Glycerol 80-88 3',5'-cyclic-nucleotide phosphodiesterase PDE1 Saccharomyces cerevisiae S288C 13-17 10075632-1 1998 A lipase-catalyzed glycerolysis reaction (a transesterification between polyunsaturated fatty acid ethyl ester [PUFA] and glycerol) was investigated. Glycerol 19-27 pumilio RNA binding family member 3 Homo sapiens 112-116 9843731-6 1998 beta2-Adrenoceptor stimulation with terbutaline induced a concentration-dependent increase in skeletal muscle glycerol levels and in tissue blood flow, whereas perfusion with beta1- or beta3-adrenoceptor agonists (dobutamine or CGP-12177) did not influence the glycerol concentration or blood flow. Glycerol 110-118 adrenoceptor beta 2 Homo sapiens 0-18 9843731-6 1998 beta2-Adrenoceptor stimulation with terbutaline induced a concentration-dependent increase in skeletal muscle glycerol levels and in tissue blood flow, whereas perfusion with beta1- or beta3-adrenoceptor agonists (dobutamine or CGP-12177) did not influence the glycerol concentration or blood flow. Glycerol 261-269 adrenoceptor beta 2 Homo sapiens 0-18 9879673-1 1998 Three Drosophila embryonic deoxyribonucleases, designated den1, den2 and den3, are identified in nuclear extracts separated by glycerol density gradient centrifugation. Glycerol 127-135 Deneddylase 1 Drosophila melanogaster 58-62 9824541-2 1998 Aquaporins are a family of intrinsic membrane proteins that function as water-selective channels (except aquaporin-3 and aquaporin-7, which are permeable to urea and glycerol as well) in the plasma membranes of many cells. Glycerol 166-174 aquaporin 3 (Gill blood group) Homo sapiens 105-116 9824541-2 1998 Aquaporins are a family of intrinsic membrane proteins that function as water-selective channels (except aquaporin-3 and aquaporin-7, which are permeable to urea and glycerol as well) in the plasma membranes of many cells. Glycerol 166-174 aquaporin 7 Homo sapiens 121-132 9822683-1 1998 The yeast transcriptional activator Adr1p controls expression of the glucose-repressible alcohol dehydrogenase gene (ADH2), genes involved in glycerol metabolism, and genes required for peroxisome biogenesis and function. Glycerol 142-150 DNA-binding transcription factor ADR1 Saccharomyces cerevisiae S288C 36-41 9822683-10 1998 In addition it complemented an ADR1-null allele for growth on glycerol and oleate media, indicating efficient activation of genes required for glycerol metabolism and peroxisome biogenesis. Glycerol 62-70 DNA-binding transcription factor ADR1 Saccharomyces cerevisiae S288C 31-35 9822683-10 1998 In addition it complemented an ADR1-null allele for growth on glycerol and oleate media, indicating efficient activation of genes required for glycerol metabolism and peroxisome biogenesis. Glycerol 143-151 DNA-binding transcription factor ADR1 Saccharomyces cerevisiae S288C 31-35 9867851-7 1999 We propose that elevated intracellular glycerol levels in the fps1 mutant shift Sln1p to the phosphorylated state and trigger the Sln1-dependent activity of the Mcm1 reporter. Glycerol 39-47 Fps1p Saccharomyces cerevisiae S288C 62-66 9867851-7 1999 We propose that elevated intracellular glycerol levels in the fps1 mutant shift Sln1p to the phosphorylated state and trigger the Sln1-dependent activity of the Mcm1 reporter. Glycerol 39-47 histidine kinase Saccharomyces cerevisiae S288C 80-85 9867851-7 1999 We propose that elevated intracellular glycerol levels in the fps1 mutant shift Sln1p to the phosphorylated state and trigger the Sln1-dependent activity of the Mcm1 reporter. Glycerol 39-47 histidine kinase Saccharomyces cerevisiae S288C 80-84 9867851-7 1999 We propose that elevated intracellular glycerol levels in the fps1 mutant shift Sln1p to the phosphorylated state and trigger the Sln1-dependent activity of the Mcm1 reporter. Glycerol 39-47 transcription factor MCM1 Saccharomyces cerevisiae S288C 161-165 9918386-6 1998 The antilipolytic response to the early phase of insulin infusion decreased (delta glycerol 9.0+/-3.5 vs. 29.9+/-6.0 micromol/l, p = 0.04) and the lipolytic response after hypoglycemia increased (AUC 122.4+/-18.0 vs. 13.4+/-16.3 micromol x l(-1) x h, p = 0.0001) comparing the experiments with or without amrinone, respectively. Glycerol 83-91 insulin Homo sapiens 49-56 9839444-7 1998 SDH2 mRNA has a very short half-life in medium with glucose (YPD) and a significantly longer half-life in medium with glycerol (YPG). Glycerol 118-126 succinate dehydrogenase iron-sulfur protein subunit SDH2 Saccharomyces cerevisiae S288C 0-4 9808702-8 1998 However, treatment of beta3-AR[WAT+BAT] mice with 3 mg/kg BRL 35135 resulted in elevated plasma glycerol levels, as well as increased stomach retention and decreased intestinal transit of radiotracer. Glycerol 96-104 adrenergic receptor, beta 3 Mus musculus 22-30 9852949-6 1998 One 435-bp RNA, bTR, was cloned from the most purified telomerase fraction and shown to be co-purified with telomerase activity in a glycerol gradient. Glycerol 133-141 G protein-coupled receptor 148 Homo sapiens 16-19 9760269-3 1998 We have reported previously that the CBP activity sediments at approximately 66 kDa in a glycerol gradient. Glycerol 89-97 CREB binding protein Homo sapiens 37-40 9830094-2 1998 There was a 40% reduction in glycerol level in the gpd2 delta mutant compared to the wild-type. Glycerol 29-37 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 Saccharomyces cerevisiae S288C 51-55 9830094-3 1998 Also the gpd1 delta mutant showed a slight decrease in glycerol formation but to a much lesser degree. Glycerol 55-63 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 9-13 9830094-9 1998 These results also show that the cells are able to cope and maintain redox balance under anaerobic conditions even if glycerol formation is substantially reduced, as observed in the gpd2 delta mutant. Glycerol 118-126 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 Saccharomyces cerevisiae S288C 182-186 9742223-6 1998 Furthermore, GRP1 can accommodate addition of glycerol or diacetylglycerol to the 1-phosphate of Ins(1,3,4,5)P4, data that are consistent with its proposed role as a putative PtdIns(3,4,5)P3 receptor. Glycerol 46-54 cytohesin 3 Homo sapiens 13-17 9828385-1 1998 A biosensor for the measurement of glycerol in FIA was constructed using covalently immobilized glycerokinase and glycerol-3-phosphate oxidase in conjunction with a Pt based hydrogen peroxide probe. Glycerol 35-43 glycerol kinase Homo sapiens 96-109 9792415-1 1998 In some species, including man and mouse, bile salt-stimulated lipase (BSSL) in milk catalyzes the hydrolysis of triacylglycerides into glycerol and free fatty acids, a reaction that is of particular importance during suckling. Glycerol 136-144 carboxyl ester lipase Mus musculus 42-69 9792415-1 1998 In some species, including man and mouse, bile salt-stimulated lipase (BSSL) in milk catalyzes the hydrolysis of triacylglycerides into glycerol and free fatty acids, a reaction that is of particular importance during suckling. Glycerol 136-144 carboxyl ester lipase Mus musculus 71-75 9742088-9 1998 Disruption of YHM2 causes a significant growth defect in the presence of nonfermentable carbon sources such as glycerol and ethanol, and the cells have defects in respiration as determined by 2,3,5,-triphenyltetrazolium chloride staining. Glycerol 111-119 Yhm2p Saccharomyces cerevisiae S288C 14-18 9742096-0 1998 Requirement of STE50 for osmostress-induced activation of the STE11 mitogen-activated protein kinase kinase kinase in the high-osmolarity glycerol response pathway. Glycerol 138-146 Ste50p Saccharomyces cerevisiae S288C 15-20 9742096-0 1998 Requirement of STE50 for osmostress-induced activation of the STE11 mitogen-activated protein kinase kinase kinase in the high-osmolarity glycerol response pathway. Glycerol 138-146 mitogen-activated protein kinase kinase kinase STE11 Saccharomyces cerevisiae S288C 62-67 9742096-11 1998 It was concluded that STE50 fulfills an essential role in the activation of the high-osmolarity glycerol response pathway by acting as an integral subunit of the STE11 MAPKKK. Glycerol 96-104 Ste50p Saccharomyces cerevisiae S288C 22-27 9742096-11 1998 It was concluded that STE50 fulfills an essential role in the activation of the high-osmolarity glycerol response pathway by acting as an integral subunit of the STE11 MAPKKK. Glycerol 96-104 mitogen-activated protein kinase kinase kinase STE11 Saccharomyces cerevisiae S288C 162-167 9744864-1 1998 The MAPKKK Ste11p functions in three Saccharomyces cerevisiae MAPK cascades [the high osmolarity glycerol (HOG), pheromone response, and pseudohyphal/invasive growth pathways], but its activation in response to high osmolarity stimulates only the HOG pathway. Glycerol 97-105 mitogen-activated protein kinase kinase kinase STE11 Saccharomyces cerevisiae S288C 11-17 9726966-5 1998 Deletion of either the ARP9 or ARP7 gene causes typical swi/snf phenotypes, including growth defects on media containing galactose, glycerol, or sucrose as sole carbon sources. Glycerol 132-140 Arp9p Saccharomyces cerevisiae S288C 23-27 9726966-5 1998 Deletion of either the ARP9 or ARP7 gene causes typical swi/snf phenotypes, including growth defects on media containing galactose, glycerol, or sucrose as sole carbon sources. Glycerol 132-140 Arp7p Saccharomyces cerevisiae S288C 31-35 9716506-7 1998 With the use of glycerol gradients we show that eIF2B forms aggregates in heat-treated extracts. Glycerol 16-24 eukaryotic translation initiation factor 2B subunit delta Rattus norvegicus 48-53 9790591-1 1998 Activation and control of the yeast HOG (High Osmolarity Glycerol) MAP kinase cascade is accomplished, in part, by a two-component sensory-response circuit comprised of the osmosensing histidine protein kinase Sln1p, the phospho-relay protein Ypd1p, and the response regulator protein Ssk1p. Glycerol 57-65 histidine kinase Saccharomyces cerevisiae S288C 210-215 9785468-3 1998 In rats fed a diet composed of 40% (w/w) glycerol, the specific activities of hepatic phenylalanine hydroxylase are decreased to about 60% of control values. Glycerol 41-49 phenylalanine hydroxylase Rattus norvegicus 86-111 9740740-9 1998 In p21.Mn(II)GMPPNP, the large deuterium modulations from the d5-glycerol exhibit saturation behavior with increasing d5-glycerol concentration, implying that glycerol, a widely used cryoprotectant, replaces the aquo ligands of the Mn(II) ion. Glycerol 65-73 H3 histone pseudogene 16 Homo sapiens 3-6 9790591-1 1998 Activation and control of the yeast HOG (High Osmolarity Glycerol) MAP kinase cascade is accomplished, in part, by a two-component sensory-response circuit comprised of the osmosensing histidine protein kinase Sln1p, the phospho-relay protein Ypd1p, and the response regulator protein Ssk1p. Glycerol 57-65 Ypd1p Saccharomyces cerevisiae S288C 243-248 9790591-1 1998 Activation and control of the yeast HOG (High Osmolarity Glycerol) MAP kinase cascade is accomplished, in part, by a two-component sensory-response circuit comprised of the osmosensing histidine protein kinase Sln1p, the phospho-relay protein Ypd1p, and the response regulator protein Ssk1p. Glycerol 57-65 mitogen-activated protein kinase kinase kinase SSK1 Saccharomyces cerevisiae S288C 285-290 9694958-1 1998 We studied the possible participation of endothelin-1 (ET-1) in the pathogenesis of renal damage in glycerol-induced acute renal failure (ARF). Glycerol 100-108 endothelin 1 Rattus norvegicus 41-53 9694958-1 1998 We studied the possible participation of endothelin-1 (ET-1) in the pathogenesis of renal damage in glycerol-induced acute renal failure (ARF). Glycerol 100-108 endothelin 1 Rattus norvegicus 55-59 9694958-6 1998 These findings indicate that ET-1 participates in the pathogenesis of acute tubular injury in glycerol-induced ARF and that ETA antagonist may be useful in the treatment of some types of human ARF. Glycerol 94-102 endothelin 1 Homo sapiens 29-33 9710867-2 1998 Secretions of arginine vasopressin (AVP) and/or other renal mechanisms may account for reduced urine output following glycerol ingestion. Glycerol 118-126 arginine vasopressin Homo sapiens 23-34 9584169-6 1998 However, unlike pho85 mutants, pcl8 pcl10 cells had normal morphologies, grew on glycerol, and showed proper regulation of acid phosphatase gene expression. Glycerol 81-89 Pcl8p Saccharomyces cerevisiae S288C 31-35 10099331-6 1998 The expression of CDC28-lacZ was analyzed in the wild type and isogenic mutant strains growing at maximal rate on glucose or in the presence of ethanol or glycerol. Glycerol 155-163 cyclin-dependent serine/threonine-protein kinase CDC28 Saccharomyces cerevisiae S288C 18-28 9696525-8 1998 RESULTS: PHi was higher in the mannitol group than in the glycerol and saline groups (P<0.05) 2 h after reperfusion. Glycerol 58-66 glucose-6-phosphate isomerase Homo sapiens 9-12 9639597-4 1998 In an arcA mutant devoid of the transcriptional regulator ArcA, glycerol was completely oxidized with nitrate as an electron acceptor, demonstrating derepression and function of the complete pathway. Glycerol 64-72 arginine deiminase Escherichia coli 6-10 9639597-4 1998 In an arcA mutant devoid of the transcriptional regulator ArcA, glycerol was completely oxidized with nitrate as an electron acceptor, demonstrating derepression and function of the complete pathway. Glycerol 64-72 arginine deiminase Escherichia coli 58-62 9845479-9 1998 In contrast, hydrolysis by beta-galactosidase showed a trend of decrease in Se-supplemented seedlings compared to the control, when glycerol was present in the medium. Glycerol 132-140 uncharacterized protein LOC106779264 Vigna radiata 27-45 9920533-1 1998 In vitro studies in transfected cells have indicated that chemical chaperones including glycerol (0.5-1.2 M) and trimethylamine oxide (TMAO, 50-100 mM) can correct defective trafficking of some proteins, including deltaF508 CFTR in cystic fibrosis and AQP2 mutants in nephrogenic diabetes insipidus. Glycerol 88-96 cystic fibrosis transmembrane conductance regulator Mus musculus 224-228 9920533-1 1998 In vitro studies in transfected cells have indicated that chemical chaperones including glycerol (0.5-1.2 M) and trimethylamine oxide (TMAO, 50-100 mM) can correct defective trafficking of some proteins, including deltaF508 CFTR in cystic fibrosis and AQP2 mutants in nephrogenic diabetes insipidus. Glycerol 88-96 aquaporin 2 Mus musculus 252-256 16414813-1 1998 Platelet Activating Factor (PAF) is a D-glycerol derived phosopholipid which is a potent endogenous mediator of inflammation. Glycerol 38-48 PCNA clamp associated factor Homo sapiens 0-26 16414813-1 1998 Platelet Activating Factor (PAF) is a D-glycerol derived phosopholipid which is a potent endogenous mediator of inflammation. Glycerol 38-48 PCNA clamp associated factor Homo sapiens 28-31 9662534-7 1998 Exogenous glycerol treatment of gly1 plants allowed chemical complementation of the mutant phenotype. Glycerol 10-18 NAD-dependent glycerol-3-phosphate dehydrogenase family protein Arabidopsis thaliana 32-36 9622075-2 1998 In this study, both LMF and Zn-alpha2-glycoprotein have been shown to stimulate glycerol release from isolated murine epididymal adipocytes with a comparable dose-response profile. Glycerol 80-88 alpha-2-glycoprotein 1, zinc-binding Homo sapiens 28-50 9584169-6 1998 However, unlike pho85 mutants, pcl8 pcl10 cells had normal morphologies, grew on glycerol, and showed proper regulation of acid phosphatase gene expression. Glycerol 81-89 Pcl10p Saccharomyces cerevisiae S288C 36-41 9590127-1 1998 A sulfated glycoglycerolipid, 1-O-(6"-sulfo-alpha-D-glucopyranosyl)-2,3-di-O-phytanyl- sn-glycerol (KN-208), a derivative of the polar lipid isolated from an archaebacterium, strongly inhibited DNA polymerase (pol) alpha and pol beta in vitro among 5 eukaryotic DNA polymerases (alpha, beta, gamma, delta, and epsilon). Glycerol 16-24 DNA polymerase Escherichia coli 194-220 9593782-8 1998 Redistribution of AQP2 mutants was also demonstrated in transfected MDCK cells, and using the chaperones TMAO and DMSO in place of glycerol in CHO cells. Glycerol 131-139 aquaporin 2 Canis lupus familiaris 18-22 9628274-3 1998 Addition of the selective PDE3-inhibitor amrinone abolished the insulin-induced decrease in adipose glycerol concentration, but did not influence the glycerol concentration in skeletal muscle. Glycerol 100-108 insulin Homo sapiens 64-71 9628274-4 1998 Nor did the PDE4-selective inhibitor rolipram or the PDE5-selective inhibitor dipyridamole influence the insulin-induced decrease in muscle tissue glycerol. Glycerol 147-155 insulin Homo sapiens 105-112 9621946-6 1998 A convenient, stable glycerol/phospholipid suspension of the substrate was used for measurement of porcine adipose tissue LPL and HSL in vitro. Glycerol 21-29 lipoprotein lipase Homo sapiens 122-125 9621946-6 1998 A convenient, stable glycerol/phospholipid suspension of the substrate was used for measurement of porcine adipose tissue LPL and HSL in vitro. Glycerol 21-29 lipase E, hormone sensitive type Homo sapiens 130-133 9674020-2 1998 Incubations with adenosine deaminase (ADA) were used for the deamination of endogenous adenosine and increased basal (155%) and isoproterenol (10(-9) M) (348%) stimulation of glycerol release from adipocytes. Glycerol 175-183 adenosine deaminase Rattus norvegicus 17-36 9588198-5 1998 Moreover, glycerol gradient analysis demonstrated that TIP49 is present in a macromolecular complex in nuclear extracts. Glycerol 10-18 RuvB like AAA ATPase 1 Homo sapiens 55-60 9553081-3 1998 The basal mechanism of eEF1A alone is determined under physiological conditions with the critical finding that glycerol and guanine nucleotide are required to prevent protein aggregation and loss of enzymatic activity. Glycerol 111-119 eukaryotic translation elongation factor 1 alpha 1 Homo sapiens 23-28 9539711-7 1998 Finally, U5-200kD was purified to homogeneity by glycerol gradient centrifugation of U5 snRNP proteins in the presence of sodium thiocyanate, followed by ion exchange chromatography. Glycerol 49-57 small nuclear ribonucleoprotein U5 subunit 200 Homo sapiens 9-17 9858131-4 1998 Most of the AQPs are only permeable to water and impermeable to small organic and inorganic molecules, except for AQP 3, 7 and 9 which are also permeable to urea and glycerol. Glycerol 166-174 aquaporin 3 (Gill blood group) Homo sapiens 114-119 9525910-8 1998 In accordance with these observations, we demonstrated that the glycolytic substrates glucose, mannose, and fructose, as well as the gluconeognic substrates glycerol and dihydroxyacetone, increased the concentration of GR mRNA in primary cultures of hepatocytes from fed rats. Glycerol 157-165 glucagon receptor Rattus norvegicus 219-221 9525951-8 1998 Furthermore, pharmacological studies showed that Colton-null red cells remain sensitive to water and glycerol flux inhibitors, supporting the idea that another proteinaceous path, probably AQP3, mediates most of the glycerol movements across red cell membranes and represents part of the residual water transport activity found in AQP1-deficient red cells. Glycerol 216-224 aquaporin 3 (Gill blood group) Homo sapiens 189-193 9575836-0 1998 Effect of insulin on glycerol production in obese adolescents. Glycerol 21-29 insulin Homo sapiens 10-17 9575870-4 1998 Myosin was characterized with electrophoresis in nondenaturing conditions, SDS-glycerol PAGE, and Western blotting with monoclonal antibodies specific for slow and fast myosin heavy chain (MHC) isoforms. Glycerol 79-87 myosin heavy chain 14 Homo sapiens 0-6 9512483-5 1998 Among carbohydrates examined, fructose, sucrose, galactose and glycerol elicited an increase in LPH mRNA accumulation along with a rise in lactase activity in the jejunum. Glycerol 63-71 lactase Rattus norvegicus 96-99 9512483-5 1998 Among carbohydrates examined, fructose, sucrose, galactose and glycerol elicited an increase in LPH mRNA accumulation along with a rise in lactase activity in the jejunum. Glycerol 63-71 lactase Rattus norvegicus 139-146 9568706-4 1998 After a 24-h incubation of TNF-alpha (10 ng/ml) with 3T3-L1 adipocytes, glycerol release increased by approximately 7-fold, and FFA release increased by approximately 44-fold. Glycerol 72-80 tumor necrosis factor Homo sapiens 27-36 9568706-5 1998 BRL 49653 (10 pmol/l) reduced TNF-alpha-induced glycerol release by approximately 50% (P < 0.001) and FFA release by approximately 90% (P < 0.001). Glycerol 48-56 tumor necrosis factor Homo sapiens 30-39 9568706-6 1998 BRL 49653 also reduced glycerol release by approximately 50% in adipocytes pretreated for 24 h with TNF-alpha. Glycerol 23-31 tumor necrosis factor Homo sapiens 100-109 9568706-7 1998 Prolonged treatment (5 days) with either BRL 49653 or another PPAR-gamma2 agonist, 15-d delta-12,14-prostaglandin J2 (15-d deltaPGJ2), blocked TNF-alpha-induced glycerol release by approximately 100%. Glycerol 161-169 tumor necrosis factor Homo sapiens 143-152 9633649-1 1998 The levels of 1,3-propanediol dehydrogenase and of the glycerol dehydrogenase in Clostridium butyricum grown on glucose-glycerol mixtures were similar to those found in extracts of cells grown on glycerol alone, which can explain the simultaneous glucose-glycerol consumption. Glycerol 120-128 gldA Clostridium butyricum 55-77 9633649-1 1998 The levels of 1,3-propanediol dehydrogenase and of the glycerol dehydrogenase in Clostridium butyricum grown on glucose-glycerol mixtures were similar to those found in extracts of cells grown on glycerol alone, which can explain the simultaneous glucose-glycerol consumption. Glycerol 120-128 gldA Clostridium butyricum 55-77 9633649-4 1998 The apparent K(m)s for the glycerol dehydrogenase was 16-fold higher for the glycerol than that for the glyceraldehyde in the case of the glyceraldehyde-3-phosphate dehydrogenase and fourfold higher for the NAD+, providing an explanation for the shift of the glycerol flow toward 1,3-propanediol when cells were grown on glucose-glycerol mixtures. Glycerol 77-85 gldA Clostridium butyricum 27-49 9633649-4 1998 The apparent K(m)s for the glycerol dehydrogenase was 16-fold higher for the glycerol than that for the glyceraldehyde in the case of the glyceraldehyde-3-phosphate dehydrogenase and fourfold higher for the NAD+, providing an explanation for the shift of the glycerol flow toward 1,3-propanediol when cells were grown on glucose-glycerol mixtures. Glycerol 77-85 gldA Clostridium butyricum 27-49 9529388-4 1998 PTC1 encodes a serine/threonine phosphatase in the high-osmolarity glycerol response (HOG) pathway. Glycerol 67-75 type 2C protein phosphatase PTC1 Saccharomyces cerevisiae S288C 0-4 9559543-10 1998 Our results also demonstrated that of the two isoforms of NAD-dependent glycerol 3-phosphate dehydrogenase, only the enzyme encoded by GPD1 appeared important for the shuttle, since the enhanced glycerol production that occurs in a gut2 delta strain proved dependent on GPD1 but not on GPD2. Glycerol 72-80 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 135-139 9559543-10 1998 Our results also demonstrated that of the two isoforms of NAD-dependent glycerol 3-phosphate dehydrogenase, only the enzyme encoded by GPD1 appeared important for the shuttle, since the enhanced glycerol production that occurs in a gut2 delta strain proved dependent on GPD1 but not on GPD2. Glycerol 72-80 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 232-236 9559543-10 1998 Our results also demonstrated that of the two isoforms of NAD-dependent glycerol 3-phosphate dehydrogenase, only the enzyme encoded by GPD1 appeared important for the shuttle, since the enhanced glycerol production that occurs in a gut2 delta strain proved dependent on GPD1 but not on GPD2. Glycerol 72-80 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 270-274 9559543-10 1998 Our results also demonstrated that of the two isoforms of NAD-dependent glycerol 3-phosphate dehydrogenase, only the enzyme encoded by GPD1 appeared important for the shuttle, since the enhanced glycerol production that occurs in a gut2 delta strain proved dependent on GPD1 but not on GPD2. Glycerol 72-80 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 Saccharomyces cerevisiae S288C 286-290 9546197-1 1998 The catalytic reduction of D-glyceraldehyde to glycerol by aldose reductase has been investigated with the combined potentials of quantum mechanics (QM) and molecular mechanics (MM) to resolve the question of whether Tyr48 or His110 serves as the proton donor during catalysis. Glycerol 47-55 aldo-keto reductase family 1 member B Homo sapiens 59-75 9530220-5 1998 The glycerol concentration in the separating gel is an important factor for successfully separating MHC-alpha and MHC-beta in myocardial samples from different species. Glycerol 4-12 major histocompatibility complex, class I, C Homo sapiens 100-103 9530220-5 1998 The glycerol concentration in the separating gel is an important factor for successfully separating MHC-alpha and MHC-beta in myocardial samples from different species. Glycerol 4-12 major histocompatibility complex, class I, C Homo sapiens 114-117 9480920-7 1998 Glycerol gradient centrifugation at the physiological salt concentration as well as native PAGE analysis of rat liver cytosol revealed oligomeric forms of HSP90alpha sedimenting at 8-10S as predominant ones. Glycerol 0-8 heat shock protein 90 alpha family class A member 1 Homo sapiens 155-165 9480920-8 1998 On the other hand, the glycerol gradient centrifugation revealed multiple forms of HSP90beta oligomers sedimenting at 6-12S. Glycerol 23-31 heat shock protein 90 alpha family class B member 1 Homo sapiens 83-92 9452432-7 1998 Upon overexpression, unclipped wild type PS-1 sediments at a lower molecular weight in glycerol velocity gradients than the endogenous fragments. Glycerol 87-95 presenilin 1 Homo sapiens 41-45 9589850-3 1998 Our studies showed that ade2 mutants were unable to grow on a synthetic medium with glycerol and hypoxanthine. Glycerol 84-92 phosphoribosylaminoimidazole carboxylase ADE2 Saccharomyces cerevisiae S288C 24-28 9589850-6 1998 Strains with single adenine mutations, ade4, ade5, ade8, ade6, ade7, or ade1 grow on glycerol- and hypoxanthine-containing media. Glycerol 85-93 amidophosphoribosyltransferase Saccharomyces cerevisiae S288C 39-43 9589850-6 1998 Strains with single adenine mutations, ade4, ade5, ade8, ade6, ade7, or ade1 grow on glycerol- and hypoxanthine-containing media. Glycerol 85-93 phosphoribosylglycinamide formyltransferase Saccharomyces cerevisiae S288C 51-55 9589850-6 1998 Strains with single adenine mutations, ade4, ade5, ade8, ade6, ade7, or ade1 grow on glycerol- and hypoxanthine-containing media. Glycerol 85-93 phosphoribosylformylglycinamidine synthase Saccharomyces cerevisiae S288C 57-61 9589850-6 1998 Strains with single adenine mutations, ade4, ade5, ade8, ade6, ade7, or ade1 grow on glycerol- and hypoxanthine-containing media. Glycerol 85-93 phosphoribosylaminoimidazolesuccinocarboxamide synthase Saccharomyces cerevisiae S288C 72-76 9478041-1 1998 By 1824, Chevreul had demonstrated that fats were esters of glycerol and fatty acids of differing chain length. Glycerol 60-68 chromosome 10 open reading frame 90 Homo sapiens 40-44 9446611-10 1998 Glycerol is synthesized from glucose, and a rate-limiting enzyme in glycerol biosynthesis is glycerol-3-phosphate dehydrogenase (GPD1 gene product), which catalyzes reduction of dihydroxyacetone phosphate to glycerol 3-phosphate. Glycerol 0-8 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 93-127 9446611-10 1998 Glycerol is synthesized from glucose, and a rate-limiting enzyme in glycerol biosynthesis is glycerol-3-phosphate dehydrogenase (GPD1 gene product), which catalyzes reduction of dihydroxyacetone phosphate to glycerol 3-phosphate. Glycerol 0-8 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 129-133 9446611-10 1998 Glycerol is synthesized from glucose, and a rate-limiting enzyme in glycerol biosynthesis is glycerol-3-phosphate dehydrogenase (GPD1 gene product), which catalyzes reduction of dihydroxyacetone phosphate to glycerol 3-phosphate. Glycerol 68-76 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 93-127 9446611-10 1998 Glycerol is synthesized from glucose, and a rate-limiting enzyme in glycerol biosynthesis is glycerol-3-phosphate dehydrogenase (GPD1 gene product), which catalyzes reduction of dihydroxyacetone phosphate to glycerol 3-phosphate. Glycerol 68-76 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 129-133 9446611-12 1998 Methylglyoxal is also synthesized from dihydroxyacetone phosphate; therefore, induction of the GLO1 gene expression by osmotic stress was thought to scavenge methylglyoxal, which increased during glycerol production for adaptation to osmotic stress. Glycerol 196-204 lactoylglutathione lyase GLO1 Saccharomyces cerevisiae S288C 95-99 9454579-4 1998 We show that ss-DNA binding to the P2S Rep dimer to form the doubly ligated P2S2 dimer occurs by a multistep process with the initial binding step occurring relatively rapidly with a bimolecular rate constant of k1 = approximately 2 x 10(6) M-1 s-1 [20 mM Tris (pH 7.5), 6 mM NaCl, 5 mM MgCl2, 5 mM 2-mercaptoethanol, and 10% (v/v) glycerol, 4 degrees C]. Glycerol 332-340 replication protein Escherichia coli 39-42 9462830-2 1998 A cls1 deletion strain is viable on glucose, galactose, ethanol, glycerol and lactate containing media, although the growth rate on non-fermentable carbon sources is decreased. Glycerol 65-73 cardiolipin synthase Saccharomyces cerevisiae S288C 2-6 9779136-4 1998 In the group of Entero-Duodenal route, the time to reach to the maximum glycerol concentration (Tmax) was faster, the maximum concentration of glycerol (Cmas) was higher, and ICP reduction rate was greater than these in the group of Naso-Gastric route. Glycerol 143-151 cytidine monophosphate N-acetylneuraminic acid synthetase Homo sapiens 153-157 9505804-13 1998 Treatment of cows with bovine somatotropin resulted in changes in mammary parameter estimates for aspartate, glutamate, leucine, phenylalanine, glucose, and glycerol. Glycerol 157-165 somatotropin Bos taurus 30-42 9515166-6 1998 The physical characteristics of Stokes" radius and sedimentation coefficient for PDE-4 enzymes cloned from each of the four isogenes were determined using size-exclusion chromatography and sedimentation in glycerol gradients. Glycerol 206-214 phosphodiesterase 4A Homo sapiens 81-86 9472476-2 1998 Although MIP has some intrinsic water and glycerol permeability and can form a gap junction like channels in the reconstituted systems, its role in the lens remained enigmatic. Glycerol 42-50 major intrinsic protein of lens fiber Bos taurus 9-12 9463885-1 1998 We present the results of a comparative study of the binding of carbon monoxide to myoglobin in glycerol/buffer solution with different concentrations of guanidine hydrochloride, under extended illumination over the temperature range 30-80 K. The changes in the Soret band indicate that the folding state of the protein is a key parameter in determining the photodissociation process and the relaxation rate of the protein. Glycerol 96-104 myoglobin Homo sapiens 83-92 10554266-2 1998 The results indicate that it is possible to distinguish the glycerol obtained from the glycerides produced in plants following C-3 and C-4 carbon fixation pathways. Glycerol 60-68 complement C3 Homo sapiens 127-130 10554266-2 1998 The results indicate that it is possible to distinguish the glycerol obtained from the glycerides produced in plants following C-3 and C-4 carbon fixation pathways. Glycerol 60-68 complement C4A (Rodgers blood group) Homo sapiens 135-138 9701703-5 1998 The amount of glycerol converted to glucose by gluconeogenesis was 9.1 micromol.kg-1.min-1 before and 10.5 micromol. Glycerol 14-22 CD59 molecule (CD59 blood group) Homo sapiens 85-90 9430617-0 1998 Effects of lens major intrinsic protein on glycerol permeability and metabolism. Glycerol 43-51 major intrinsic protein of lens fiber L homeolog Xenopus laevis 16-39 9430617-2 1998 When expressed in Xenopus oocytes, MIP increased both glycerol permeability and the activity of glycerol kinase. Glycerol 54-62 major intrinsic protein of lens fiber L homeolog Xenopus laevis 35-38 9430617-3 1998 Glycerol permeability (pGly) was 2.3 +/- 0.23 x 10(-6) cm sec-1 with MIP vs. 0.92 +/- 0.086 x 10(-6) cm sec-1 in control oocytes. Glycerol 0-8 major intrinsic protein of lens fiber L homeolog Xenopus laevis 69-72 9430617-5 1998 MIP-enhanced glycerol phosphorylation, resulting in increased incorporation of glycerol into lipids. Glycerol 13-21 major intrinsic protein of lens fiber L homeolog Xenopus laevis 0-3 9430617-5 1998 MIP-enhanced glycerol phosphorylation, resulting in increased incorporation of glycerol into lipids. Glycerol 79-87 major intrinsic protein of lens fiber L homeolog Xenopus laevis 0-3 9430617-7 1998 Based on methods we present to distinguish these mechanisms, MIP increased the maximum rate of phosphorylation by glycerol kinase (0.12 +/- 0.03 vs. 0.06 +/- 0.01 pmol min-1 cell-1) without changing the binding of glycerol to the kinase (KM approximately 10 micron). Glycerol 114-122 major intrinsic protein of lens fiber L homeolog Xenopus laevis 61-64 9711577-2 1998 By including glycerol (osmolyte protectant) and lipid during the solubilization and chromatography procedures most of the biological activity of Pgp can be retained. Glycerol 13-21 phosphoglycolate phosphatase Homo sapiens 145-148 9459299-2 1997 Addition of glucose to glycerol-grown yeast cells is known to cause a transient increase in the cAMP level and recent work has indicated a specific involvement of Pde1 in this response. Glycerol 23-31 3',5'-cyclic-nucleotide phosphodiesterase PDE1 Saccharomyces cerevisiae S288C 163-167 9389759-17 1997 In short-term labeling studies, apo E-deficient and control cells showed a similar time-dependent accumulation of [3H]TG formed from [3H]glycerol, yet secretion of newly synthesized VLDL-associated [3H]TG by apo E-deficient cells was reduced by 60 and 73% in the absence and presence of oleate, respectively. Glycerol 137-145 apolipoprotein E Mus musculus 32-37 9369468-13 1997 Expression of AQP3 increased glycerol permeability (Pgly) 3.1-fold, whereas Pgly of Y212W-expressing oocytes was similar to Pgly of control oocytes. Glycerol 29-37 aquaporin 3 (Gill blood group) Homo sapiens 14-18 9367889-8 1997 In addition, to investigate whether the location of HO-1 protein induced by glycerol injection is restricted to injured region or not in the kidney, we determined the localization of HO-1 protein using immunohistochemical staining. Glycerol 76-84 heme oxygenase 1 Rattus norvegicus 52-56 9402029-4 1997 Such antibodies also after the GTP synthesizing ability of specific membrane fractions isolated from glycerol gradients of such cells, suggesting that a membrane-associated Ndk-G-protein homologue complex is responsible for part of GTP synthesis in these bacteria. Glycerol 101-109 NME/NM23 nucleoside diphosphate kinase 4 Homo sapiens 173-176 9514124-3 1997 In a fed-batch fermenter, a cell density of approximately 300 mg/ml was achieved by controlled glycerol feeding for a total of 24 h. After 72 h of methanol induction, the secreted BLG reached levels of > 1 g/l. Glycerol 95-103 beta-lactoglobulin Bos taurus 180-183 16728208-9 1997 Addition of a cryopreservation medium containing egg yolk, skim-milk, glycerol and sucrose to equine spermatozoa and subsequent cryopreservation significantly (P < 0.05) increased acrosin amidase activity compared with spermatozoa from raw semen. Glycerol 70-78 acrosin Equus caballus 183-190 9401039-0 1997 Characteristics of Fps1-dependent and -independent glycerol transport in Saccharomyces cerevisiae. Glycerol 51-59 Fps1p Saccharomyces cerevisiae S288C 19-23 9401039-5 1997 Fps1p, therefore, may be involved in the regulation of lipid metabolism in S. cerevisiae, affecting membrane permeability in addition to fulfilling its specific role in glycerol transport. Glycerol 169-177 Fps1p Saccharomyces cerevisiae S288C 0-5 9350335-4 1997 In a competitive binding inhibition assay using neutrophil and PBMC glycerol purified plasma membranes, high affinity binding in the nanomolar range was detected to Lys-BK and BK but with [des-arg9]-BK a 10-100 fold lower order affinity was observed this being indicative of pharmacologically defined B2 characteristics. Glycerol 68-76 kininogen 1 Homo sapiens 169-171 9350335-4 1997 In a competitive binding inhibition assay using neutrophil and PBMC glycerol purified plasma membranes, high affinity binding in the nanomolar range was detected to Lys-BK and BK but with [des-arg9]-BK a 10-100 fold lower order affinity was observed this being indicative of pharmacologically defined B2 characteristics. Glycerol 68-76 kininogen 1 Homo sapiens 176-178 9350335-4 1997 In a competitive binding inhibition assay using neutrophil and PBMC glycerol purified plasma membranes, high affinity binding in the nanomolar range was detected to Lys-BK and BK but with [des-arg9]-BK a 10-100 fold lower order affinity was observed this being indicative of pharmacologically defined B2 characteristics. Glycerol 68-76 kininogen 1 Homo sapiens 176-178 9353925-1 1997 High-osmolarity-induced expression of the small heat-shock gene HSP12 is regulated by the HOG (high-osmolarity glycerol) pathway and PKA (protein kinase A). Glycerol 111-119 lipid-binding protein HSP12 Saccharomyces cerevisiae S288C 64-69 9315631-3 1997 However, cells missing the POR1 gene (delta por1) were able to grow on yeast media containing a nonfermentable carbon source (glycerol) but not on such media at elevated temperature (37 degrees C). Glycerol 126-134 porin POR1 Saccharomyces cerevisiae S288C 27-31 9315631-3 1997 However, cells missing the POR1 gene (delta por1) were able to grow on yeast media containing a nonfermentable carbon source (glycerol) but not on such media at elevated temperature (37 degrees C). Glycerol 126-134 porin POR1 Saccharomyces cerevisiae S288C 44-48 9315631-5 1997 To identify proteins that could functionally substitute for POR1, we have screened a yeast genomic library for genes which, when overexpressed, can correct the growth defect of delta por1 yeast grown on glycerol at 37 degrees C. This screen identified a second yeast VDAC gene, POR2, encoding a protein (YVDAC2) with 49% amino acid sequence identity to the previously identified yeast VDAC protein (YVDAC1). Glycerol 203-211 porin POR1 Saccharomyces cerevisiae S288C 60-64 9315631-5 1997 To identify proteins that could functionally substitute for POR1, we have screened a yeast genomic library for genes which, when overexpressed, can correct the growth defect of delta por1 yeast grown on glycerol at 37 degrees C. This screen identified a second yeast VDAC gene, POR2, encoding a protein (YVDAC2) with 49% amino acid sequence identity to the previously identified yeast VDAC protein (YVDAC1). Glycerol 203-211 porin POR1 Saccharomyces cerevisiae S288C 183-187 9315631-7 1997 Deletion of the POR2 gene alone had no detectable phenotype, while yeasts with deletions of both the POR1 and POR2 genes were viable and able to grow on glycerol at 30 degrees C, albeit more slowly than delta por1 single mutants. Glycerol 153-161 porin POR1 Saccharomyces cerevisiae S288C 101-105 9315631-7 1997 Deletion of the POR2 gene alone had no detectable phenotype, while yeasts with deletions of both the POR1 and POR2 genes were viable and able to grow on glycerol at 30 degrees C, albeit more slowly than delta por1 single mutants. Glycerol 153-161 putative porin POR2 Saccharomyces cerevisiae S288C 110-114 9315631-12 1997 In contrast, when the VDAC gene from Drosophila melanogaster was expressed in delta por1 yeast cells, VDAC-like channels could be detected in the mitochondria by both bilayer and liposome techniques, yet the cells failed to grow on glycerol at 37 degrees C. Thus, channel-forming activity does not seem to be either necessary or sufficient to restore growth on nonfermentable carbon sources, indicating that VDAC mediates cellular functions that do not depend on the ability to form channels. Glycerol 232-240 porin Drosophila melanogaster 22-26 9315631-12 1997 In contrast, when the VDAC gene from Drosophila melanogaster was expressed in delta por1 yeast cells, VDAC-like channels could be detected in the mitochondria by both bilayer and liposome techniques, yet the cells failed to grow on glycerol at 37 degrees C. Thus, channel-forming activity does not seem to be either necessary or sufficient to restore growth on nonfermentable carbon sources, indicating that VDAC mediates cellular functions that do not depend on the ability to form channels. Glycerol 232-240 porin POR1 Saccharomyces cerevisiae S288C 84-88 9315631-12 1997 In contrast, when the VDAC gene from Drosophila melanogaster was expressed in delta por1 yeast cells, VDAC-like channels could be detected in the mitochondria by both bilayer and liposome techniques, yet the cells failed to grow on glycerol at 37 degrees C. Thus, channel-forming activity does not seem to be either necessary or sufficient to restore growth on nonfermentable carbon sources, indicating that VDAC mediates cellular functions that do not depend on the ability to form channels. Glycerol 232-240 porin Drosophila melanogaster 102-106 9315631-12 1997 In contrast, when the VDAC gene from Drosophila melanogaster was expressed in delta por1 yeast cells, VDAC-like channels could be detected in the mitochondria by both bilayer and liposome techniques, yet the cells failed to grow on glycerol at 37 degrees C. Thus, channel-forming activity does not seem to be either necessary or sufficient to restore growth on nonfermentable carbon sources, indicating that VDAC mediates cellular functions that do not depend on the ability to form channels. Glycerol 232-240 porin Drosophila melanogaster 102-106 9305894-8 1997 The disruption of the p30 gene caused the growth retardation of yeast cells in a glycerol medium but not in a glucose medium, i.e. the impairment of the mitochondrial ATP synthesis. Glycerol 81-89 centromere protein V Homo sapiens 22-25 9305930-5 1997 Employing in vitro initiation and elongation on both natural viral templates and synthetic oligonucleotides followed by glycerol gradient separation of the reaction products, we established that pTP and pol are separated during elongation. Glycerol 120-128 regenerating family member 1 alpha Homo sapiens 195-198 9281576-6 1997 Two of these cell fusion mutants are defective in the FPS1 gene, which codes for a glycerol facilitator (Luyten, K., J. Albertyn, W.F. Glycerol 83-91 Fps1p Saccharomyces cerevisiae S288C 54-58 9315717-9 1997 When cultures were treated with 0.3 M NaCl or 0.6 M sorbitol for 1 h, glycerol production was similar for both strains, but after 3 h of the same treatment, total glycerol production was higher in the CIF1 strain. Glycerol 163-171 alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1 Saccharomyces cerevisiae S288C 201-205 9339340-2 1997 Disruption of CBT1 (corresponding to ORF YKL 208W) results in a respiratory deficiency (no growth on acetate and ethanol, a reduced growth on glycerol, and a moderate growth on lactate). Glycerol 142-150 Cbt1p Saccharomyces cerevisiae S288C 14-18 9410723-12 1997 The concentrations of NEFA and glycerol in plasma during the infusion of 5 mU insulin.kg-1.min-1 were significantly higher during late pregnancy than during non-pregnancy (NEFA: 0.41, 0.04 mmol.l-1; glycerol: 96, 29 mumol.l-1, respectively). Glycerol 31-39 LOC105613195 Ovis aries 78-85 9410723-12 1997 The concentrations of NEFA and glycerol in plasma during the infusion of 5 mU insulin.kg-1.min-1 were significantly higher during late pregnancy than during non-pregnancy (NEFA: 0.41, 0.04 mmol.l-1; glycerol: 96, 29 mumol.l-1, respectively). Glycerol 199-207 LOC105613195 Ovis aries 78-85 9261170-5 1997 When grown on either glucose or glycerol as a carbon source, a glo2 glo4 double deletion strain contains no glyoxalase II activity at all and shows no obvious phenotype during vegetative growth. Glycerol 32-40 hydroxyacylglutathione hydrolase GLO2 Saccharomyces cerevisiae S288C 63-72 9261170-7 1997 Whereas the GLO2 gene is expressed on both glucose and glycerol, the GLO4 gene is only active on glycerol. Glycerol 55-63 hydroxyacylglutathione hydrolase GLO2 Saccharomyces cerevisiae S288C 12-16 9261170-7 1997 Whereas the GLO2 gene is expressed on both glucose and glycerol, the GLO4 gene is only active on glycerol. Glycerol 97-105 hydroxyacylglutathione hydrolase GLO4 Saccharomyces cerevisiae S288C 69-73 9252401-7 1997 AQP7 also facilitated glycerol and urea transport by 5- and 9-fold, respectively. Glycerol 22-30 aquaporin 7 Rattus norvegicus 0-4 9244391-6 1997 Spontaneous suppressor mutants that restore fast growth on glycerol medium to strains harboring two idh2 alleles were isolated, and a large percentage of the suppressor mutations have been identified within the CIT1 gene and at several other loci. Glycerol 59-67 citrate (Si)-synthase CIT1 Saccharomyces cerevisiae S288C 211-215 9244391-11 1997 Similarly, eight cit1 alleles were sequenced to understand their characteristics as glycerol suppressors of idh2. Glycerol 84-92 citrate (Si)-synthase CIT1 Saccharomyces cerevisiae S288C 17-21 9244391-11 1997 Similarly, eight cit1 alleles were sequenced to understand their characteristics as glycerol suppressors of idh2. Glycerol 84-92 isocitrate dehydrogenase (NAD(+)) IDH2 Saccharomyces cerevisiae S288C 108-112 9250454-9 1997 Glycerol levels showed a slight increase before lunch and dinner, suggestive of enhanced lipolytic activity and compatible with the lower insulin levels. Glycerol 0-8 insulin Homo sapiens 138-145 9288906-2 1997 Utilizing zone velocity sedimentation in glycerol gradients we found that recombinant HIV-1 Nef non-covalently associates with actin forming a high-molecular-mass complex of 150-300 kDa. Glycerol 41-49 Nef Human immunodeficiency virus 1 92-95 9298657-4 1997 One of the presumed key-enzymes in the production of glycerol in the cell is glycerol 3-phosphate dehydrogenase encoded by the GPD1 gene. Glycerol 53-61 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 127-131 9235913-7 1997 We now find that this apparent increase in activity is accounted for, in part, by glycerol acting as an alternative acceptor for the cleaved fatty acid, as is the case for this enzyme"s phospholipase A2 (PLA2) activity. Glycerol 82-90 phospholipase A2 group IB Homo sapiens 186-202 9235913-7 1997 We now find that this apparent increase in activity is accounted for, in part, by glycerol acting as an alternative acceptor for the cleaved fatty acid, as is the case for this enzyme"s phospholipase A2 (PLA2) activity. Glycerol 82-90 phospholipase A2 group IB Homo sapiens 204-208 9301044-0 1997 Dynamic and thermodynamic effects of glycerol on bovine serum albumin in aqueous solution: a tryptophan phosphorescence study. Glycerol 37-45 albumin Homo sapiens 56-69 9301044-1 1997 The phosphorescence decay of bovine serum albumin in water-glycerol solutions at room temperature is analysed by the maximum entropy method. Glycerol 59-67 albumin Homo sapiens 36-49 9228030-5 1997 A recombinant adenovirus containing the bacterial glycerol kinase gene (AdCMV-GlpK) was constructed and used to express the enzyme in islets and INS-1 cells, resulting in insulin secretion in response to glycerol. Glycerol 50-58 insulin 1 Rattus norvegicus 145-150 9228030-6 1997 In AdCMV-GlpK-treated INS-1 cells a greater proportion of glycerol is converted to lactate and a lesser proportion is oxidized compared with glucose. Glycerol 58-66 insulin 1 Rattus norvegicus 22-27 9211927-2 1997 Two genes encoding protein-tyrosine phosphatases, PTP2, and a new phosphatase, PTP3, have been isolated in a genetic selection for negative regulators of an osmotic stress response pathway called HOG, for high osmolarity glycerol, in budding yeast. Glycerol 221-229 tyrosine protein phosphatase PTP2 Saccharomyces cerevisiae S288C 50-54 9201997-7 1997 Binding of MAG, SMP, and sialoadhesin was abrogated by chemical modification of either the sialic acid carboxylic acid group or glycerol side chain on a target ganglioside. Glycerol 128-136 myelin associated glycoprotein Homo sapiens 11-14 9201997-7 1997 Binding of MAG, SMP, and sialoadhesin was abrogated by chemical modification of either the sialic acid carboxylic acid group or glycerol side chain on a target ganglioside. Glycerol 128-136 sialic acid binding Ig like lectin 1 Homo sapiens 25-37 9315342-1 1997 Norepinephrine and angiotensin II are potent vasoconstrictors and stimulate thermogenesis (oxygen uptake) as well as lactate and glycerol efflux in the constant-flow perfused rat hind limb at rest. Glycerol 129-137 angiotensinogen Rattus norvegicus 19-33 9211927-2 1997 Two genes encoding protein-tyrosine phosphatases, PTP2, and a new phosphatase, PTP3, have been isolated in a genetic selection for negative regulators of an osmotic stress response pathway called HOG, for high osmolarity glycerol, in budding yeast. Glycerol 221-229 tyrosine protein phosphatase PTP3 Saccharomyces cerevisiae S288C 79-83 9245823-6 1997 Determination of intracellular triose-phosphate and fructose 1,6-biphosphate concentrations demonstrated that glyceraldehyde-3-phosphate dehydrogenase is the limiting step in glycerol dissimilation. Glycerol 175-183 AL522_RS14985 Pantoea agglomerans 110-150 9267436-1 1997 The MBR1 gene was isolated as a multicopy suppressor of the phenotype on glycerol medium of a Saccharomyces cerevisiae strain mutant for the Hap2/3/4/5 transactivator complex. Glycerol 73-81 Mbr1p Saccharomyces cerevisiae S288C 4-8 9267436-2 1997 In this paper, we show that Mbr1p is a limiting factor for growth on glycerol medium under the following sub-optimal culture conditions: in late growth phase, at low temperature, at high external pH or in the presence of 1,10-phenanthroline. Glycerol 69-77 Mbr1p Saccharomyces cerevisiae S288C 28-33 9765825-2 1997 That study showed that activities of key enzymes of the downstream metabolism of glycerol--glyceradehyde-3-phosphate dehydrogenase (GAP-DH), lactate dehydrogenase and pyruvate formate lyase--were strongly dependent on the culture pH. Glycerol 81-89 AL522_RS14420 Pantoea agglomerans 141-162 9765825-2 1997 That study showed that activities of key enzymes of the downstream metabolism of glycerol--glyceradehyde-3-phosphate dehydrogenase (GAP-DH), lactate dehydrogenase and pyruvate formate lyase--were strongly dependent on the culture pH. Glycerol 81-89 AL522_RS08050 Pantoea agglomerans 184-189 9234667-2 1997 Variations in the glycerol 3-phosphate dehydrogenase (GPDH) level and similar trends for alcohol dehydrogenase (ADH), pyruvate decarboxylase and glycerol-3-phosphatase were found when low and high glycerol-forming wine yeast strains were compared. Glycerol 18-26 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 54-58 9234667-3 1997 GPDH is thus a limiting enzyme for glycerol production. Glycerol 35-43 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 0-4 9234667-7 1997 Overexpression of GPD1 on synthetic must (200 g/l glucose) resulted in a substantial increase in glycerol production ( x 4) at the expense of ethanol. Glycerol 97-105 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 18-22 9195910-0 1997 Water and glycerol permeabilities of aquaporins 1-5 and MIP determined quantitatively by expression of epitope-tagged constructs in Xenopus oocytes. Glycerol 10-18 aquaporin 1 (Colton blood group) L homeolog Xenopus laevis 37-51 9224427-2 1997 Significant differences were found between RBC from AD and ND patients or young controls respectively for annexin V-binding (45.5 +/- 18.0% vs 27.1 +/- 14.7 and 2.7 +/- 1.9, p = .003), fraction of glycerol resistant cells (30.8 +/- 11.1% vs 19.6 +/- 6.4 and 10.2 +/- 3.1, p = .026), cell electrophoretic mobility in polymer (1.028 +/- 0.022 microns sec-1 V-1 cm vs 1.046 +/- 0.022 and 1.053 +/- 0.021, p = .02) and only limited significance for the filterability (1.46 +/- 0.12 msec vs 1.58 +/- 0.11 and 1.54 +/- 0.11, p = 0.1). Glycerol 197-205 annexin A5 Homo sapiens 106-115 9195910-5 1997 The 10-min uptake of [3H]glycerol was increased significantly (range of 4.5-8-fold over control) in oocytes expressing untagged AQP3 (GLIP) and each of the four tagged AQP3 constructs; [3H]glycerol uptake was not increased in oocytes expressing AQP1, AQP2, AQP4, AQP5, or MIP. Glycerol 25-33 aquaporin 3 (Gill blood group) S homeolog Xenopus laevis 168-172 9195910-5 1997 The 10-min uptake of [3H]glycerol was increased significantly (range of 4.5-8-fold over control) in oocytes expressing untagged AQP3 (GLIP) and each of the four tagged AQP3 constructs; [3H]glycerol uptake was not increased in oocytes expressing AQP1, AQP2, AQP4, AQP5, or MIP. Glycerol 25-33 aquaporin 1 (Colton blood group) L homeolog Xenopus laevis 245-249 9195910-5 1997 The 10-min uptake of [3H]glycerol was increased significantly (range of 4.5-8-fold over control) in oocytes expressing untagged AQP3 (GLIP) and each of the four tagged AQP3 constructs; [3H]glycerol uptake was not increased in oocytes expressing AQP1, AQP2, AQP4, AQP5, or MIP. Glycerol 25-33 aquaporin 2 S homeolog Xenopus laevis 251-255 9195910-5 1997 The 10-min uptake of [3H]glycerol was increased significantly (range of 4.5-8-fold over control) in oocytes expressing untagged AQP3 (GLIP) and each of the four tagged AQP3 constructs; [3H]glycerol uptake was not increased in oocytes expressing AQP1, AQP2, AQP4, AQP5, or MIP. Glycerol 25-33 aquaporin 4 L homeolog Xenopus laevis 257-261 9195927-11 1997 In addition to high water permeability, SM vesicles also show high mercury-sensitive permeability to glycerol and formamide, but not urea, suggesting that NOD 26 also fluxes these solutes. Glycerol 101-109 nodulin-26 Glycine max 155-161 9188468-4 1997 In contrast, glycerol, which promotes DeltaF508-CFTR maturation in vivo, increases the folding yield of NBD1DeltaF and reduces the off pathway rate in vitro, although it does not significantly alter the free energy of stability. Glycerol 13-21 CF transmembrane conductance regulator Homo sapiens 48-52 9195910-5 1997 The 10-min uptake of [3H]glycerol was increased significantly (range of 4.5-8-fold over control) in oocytes expressing untagged AQP3 (GLIP) and each of the four tagged AQP3 constructs; [3H]glycerol uptake was not increased in oocytes expressing AQP1, AQP2, AQP4, AQP5, or MIP. Glycerol 25-33 aquaporin 3 (Gill blood group) S homeolog Xenopus laevis 128-132 9154823-3 1997 Strains in which RTS1 has been disrupted are temperature sensitive (ts) for growth, are hypersensitive to ethanol, are unable to grow with glycerol as their only carbon source, and accumulate at nonpermissive temperatures predominantly as large-budded cells with a 2N DNA content and a nondivided nucleus. Glycerol 139-147 protein phosphatase 2A regulatory subunit RTS1 Saccharomyces cerevisiae S288C 17-21 9154823-6 1997 Expression of truncated forms of Rts1p can also partially suppress the ts phenotype and can fully suppress the inability of cells to grow on glycerol and the hypersensitivity of cells to ethanol. Glycerol 141-149 protein phosphatase 2A regulatory subunit RTS1 Saccharomyces cerevisiae S288C 33-38 9187238-7 1997 The subunit organization of recombinant EIAV dUTPase was probed by gel filtration, glycerol gradient centrifugation, and chemical cross-linking, and is a trimer. Glycerol 83-91 Deoxyuridine triphosphatase Drosophila melanogaster 45-52 9148932-2 1997 In yeast glycerol-3-phosphate dehydrogenase 1 is essential for synthesis of the osmoprotectant glycerol and is osmotically regulated via the high osmolarity glycerol (HOG1) kinase pathway. Glycerol 9-17 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 167-171 9148932-2 1997 In yeast glycerol-3-phosphate dehydrogenase 1 is essential for synthesis of the osmoprotectant glycerol and is osmotically regulated via the high osmolarity glycerol (HOG1) kinase pathway. Glycerol 95-103 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 167-171 9143349-3 1997 CYP2E1 substrates or ligands such as 4-methylpyrazole, ethanol, glycerol, and dimethyl sulfoxide protected CYP2E1 against this rapid degradation, whereas CCl4 accelerated this process. Glycerol 64-72 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 0-6 9143349-3 1997 CYP2E1 substrates or ligands such as 4-methylpyrazole, ethanol, glycerol, and dimethyl sulfoxide protected CYP2E1 against this rapid degradation, whereas CCl4 accelerated this process. Glycerol 64-72 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 107-113 9143367-0 1997 Presence of glycerol masks the effects of phosphorylation on the catalytic efficiency of cytosolic phospholipase A2. Glycerol 12-20 phospholipase A2 group IVA Homo sapiens 89-115 9180011-7 1997 In a third study, MLC20 phosphorylation levels in electrically stimulated arterial muscle were determined by urea glycerol gel electrophoresis and Western blot analyses. Glycerol 114-122 myosin light chain 12B Rattus norvegicus 18-23 9141630-0 1997 Glycerol and polylysine synergize in their ability to rupture vesicular membranes: a mechanism for increased transferrin-polylysine-mediated gene transfer. Glycerol 0-8 transferrin Homo sapiens 109-120 9212976-5 1997 In hyperosmotic 150 mM NaCl or 1.0 M glycerol medium, the stress response to heat shock was inhibited at the levels of HSF activation, HSP70 mRNA accumulation, and HSP70 synthesis. Glycerol 37-45 interleukin 6 Homo sapiens 119-122 9212976-5 1997 In hyperosmotic 150 mM NaCl or 1.0 M glycerol medium, the stress response to heat shock was inhibited at the levels of HSF activation, HSP70 mRNA accumulation, and HSP70 synthesis. Glycerol 37-45 heat shock protein family A (Hsp70) member 4 Homo sapiens 135-140 9212976-5 1997 In hyperosmotic 150 mM NaCl or 1.0 M glycerol medium, the stress response to heat shock was inhibited at the levels of HSF activation, HSP70 mRNA accumulation, and HSP70 synthesis. Glycerol 37-45 heat shock protein family A (Hsp70) member 4 Homo sapiens 164-169 9212976-6 1997 In vitro activation of HSF showed that inhibition of this activation by hyperosmotic NaCl or glycerol stress was not irreversible. Glycerol 93-101 interleukin 6 Homo sapiens 23-26 9141630-1 1997 The presence of about 1.2 M glycerol during transfection with DNA/transferrin-polylysine and DNA/polylysine complexes dramatically increases transgene expression in a variety of cell types, provided that the complexes have an excess of polylysine. Glycerol 28-36 transferrin Homo sapiens 66-77 9029304-3 1997 The Corona discharges decreased the number of glycerol molecules at the membrane surface and from a biological point of view, produced a threefold increase in insulin diffusion. Glycerol 46-54 insulin Homo sapiens 159-166 9092668-3 1997 Such strains bearing a deletion of the CBP2 gene adapt slowly to growth in glycerol/ethanol media implying a defect in derepression. Glycerol 75-83 Cbp2p Saccharomyces cerevisiae S288C 39-43 9083049-5 1997 A nuclear gene, designated COQ5 was isolated from a yeast genomic library based on its ability to restore growth of a representative coq5 mutant on media containing glycerol as the sole carbon source. Glycerol 165-173 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase Saccharomyces cerevisiae S288C 27-31 9083049-5 1997 A nuclear gene, designated COQ5 was isolated from a yeast genomic library based on its ability to restore growth of a representative coq5 mutant on media containing glycerol as the sole carbon source. Glycerol 165-173 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase Saccharomyces cerevisiae S288C 133-137 9113273-0 1997 Glycerol increases content and activity of human cytochrome P-4502E1 in a transduced HepG2 cell line by protein stabilization. Glycerol 0-8 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 49-68 9113273-1 1997 Glycerol is widely used to stabilize cytochrome P-450 and prevent its transformation to cytochrome P-420. Glycerol 0-8 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 48-53 9113273-2 1997 The effect of glycerol on the content and activity of human cytochrome P-4502E1 (CYP2E1) in a HepG2 cell line that stably and constitutively expresses this P-450 was evaluated by immunoassays and oxidation of p-nitrophenol. Glycerol 14-22 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 60-79 9113273-2 1997 The effect of glycerol on the content and activity of human cytochrome P-4502E1 (CYP2E1) in a HepG2 cell line that stably and constitutively expresses this P-450 was evaluated by immunoassays and oxidation of p-nitrophenol. Glycerol 14-22 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 81-87 9113273-2 1997 The effect of glycerol on the content and activity of human cytochrome P-4502E1 (CYP2E1) in a HepG2 cell line that stably and constitutively expresses this P-450 was evaluated by immunoassays and oxidation of p-nitrophenol. Glycerol 14-22 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 71-76 9113273-3 1997 Addition of 100 to 200 mM glycerol to the culture medium resulted in a 2 1/2- to 3-fold increase in the content and activity of CYP2E1 in microsomes isolated from the cells. Glycerol 26-34 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 128-134 9113273-7 1997 Glycerol prevented or decreased this loss of CYP2E1 content and activity. Glycerol 0-8 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 45-51 9113273-10 1997 Stabilization of CYP2E1 protein by glycerol was not additive or synergistic with the increase of CYP2E1 by ethanol or 4-methylpyrazole, suggesting that all three agents elevate CYP2E1 by a similar type of mechanism in this model. Glycerol 35-43 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 17-23 9113273-11 1997 These results indicate that glycerol can interact with human CYP2E1 to stabilize it against proteolytic degradation, increasing the half-life of the enzyme and thereby elevating the content and activity of CYP2E1. Glycerol 28-36 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 61-67 9113273-11 1997 These results indicate that glycerol can interact with human CYP2E1 to stabilize it against proteolytic degradation, increasing the half-life of the enzyme and thereby elevating the content and activity of CYP2E1. Glycerol 28-36 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 206-212 9140965-4 1997 Deletion of the CIT3 gene in a delta cit1 background severely reduced growth on the respiratory substrate glycerol, whilst multiple copies of the CIT3 gene in a delta cit1 background significantly improved growth on acetate. Glycerol 106-114 citrate (Si)-synthase CIT3 Saccharomyces cerevisiae S288C 16-20 9141689-5 1997 A cDNA clone under the yeast ADH1 promoter was able to substitute for the yeast TBP gene in vivo; however, the transformants obtained grew poorly at 35 degrees C and on galactose and glycerol at 30 degrees C, though they could grow in the presence of copper ions or aminotriazole at this temperature. Glycerol 183-191 alcohol dehydrogenase ADH1 Saccharomyces cerevisiae S288C 29-33 9086280-9 1997 Neopterin, a propane triol derivative of pterin, also binds to RTA as revealed by the X-ray structure of its complex with RTA. Glycerol 13-26 MAS related GPR family member F Homo sapiens 63-66 9062130-7 1997 Stimulation by glycerol reduced the accumulating levels of phosphocysteinyl enzyme in both cases of full length SHP-1 and the PTPase domain; however, glycerol is not acting as a cosubstrate since no glycerophosphate product was detectable. Glycerol 15-23 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 112-117 9062130-9 1997 Glycerol probably relaxes the compact structure of SHP-1 and the PTP domain, thereby accelerating the catalytic rates in both cases by increasing forward reaction rates of ES and EP(i). Glycerol 0-8 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 51-56 9138703-10 1997 Adenosine A1 receptor mRNA levels were significantly elevated 0.5, 16 and 48 h following induction of ARF with glycerol, whilst no change was noted in mRNA levels for beta-actin at the same time points. Glycerol 111-119 adenosine A1 receptor Rattus norvegicus 0-21 9138703-13 1997 This study indicates that glycerol-induced ARF in the rat is associated with an increase in renal adenosine A1 receptor density which appears to result from increased transcription of the gene for this receptor. Glycerol 26-34 adenosine A1 receptor Rattus norvegicus 98-119 9138703-14 1997 An increase in adenosine A1 receptor density in renal resistance vessels may explain, at least in part, the enhanced renal vasoconstrictor response to adenosine in glycerol-induced ARF that was noted in a previous study. Glycerol 164-172 adenosine A1 receptor Rattus norvegicus 15-36 9048601-9 1997 FFA levels were suppressed to a greater extent with peripheral than portal or 1/2 periph, whereas the responses of lactate alanine and glycerol to insulin infusion were similar in the three groups. Glycerol 135-143 insulin Canis lupus familiaris 147-154 9125682-3 1997 Both NE and ADA caused dose-dependent stimulation of lipolysis, elevating glycerol release twofold to threefold over baseline. Glycerol 74-82 adenosine deaminase Rattus norvegicus 12-15 9062925-5 1997 Under aerobic conditions, the recombinant strain expressing the mae1 and mae2 genes efficiently degraded 8 g/L of malate in a glycerol-ethanol medium within 7 days. Glycerol 126-134 malate dehydrogenase (oxaloacetate-decarboxylating) Saccharomyces cerevisiae S288C 64-68 9042961-1 1997 We deleted the PBS2 gene encoding the MAP kinase activator of the osmosignaling HOG pathway in Saccharomyces cerevisiae and examined the effects on the kinetics of the osmoregulatory glycerol response and protein induction during adaptation to 0.7 M NaCl. Glycerol 183-191 mitogen-activated protein kinase kinase PBS2 Saccharomyces cerevisiae S288C 15-19 9042961-5 1997 Northern analysis of the salt induced transcription of GPD1 and GPP2, encoding the cytosolic glycerol-3-phosphate dehydrogenase and glycerol-3-phosphatase involved in the osmostress induced glycerol production, demonstrated an about 20-fold PBS2-dependent transient activation, in agreement with the previously reported transient nature of the signal transduced by the HOG pathway. Glycerol 93-101 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 55-59 9042961-5 1997 Northern analysis of the salt induced transcription of GPD1 and GPP2, encoding the cytosolic glycerol-3-phosphate dehydrogenase and glycerol-3-phosphatase involved in the osmostress induced glycerol production, demonstrated an about 20-fold PBS2-dependent transient activation, in agreement with the previously reported transient nature of the signal transduced by the HOG pathway. Glycerol 93-101 glycerol-1-phosphatase HOR2 Saccharomyces cerevisiae S288C 64-68 9042961-5 1997 Northern analysis of the salt induced transcription of GPD1 and GPP2, encoding the cytosolic glycerol-3-phosphate dehydrogenase and glycerol-3-phosphatase involved in the osmostress induced glycerol production, demonstrated an about 20-fold PBS2-dependent transient activation, in agreement with the previously reported transient nature of the signal transduced by the HOG pathway. Glycerol 93-101 mitogen-activated protein kinase kinase PBS2 Saccharomyces cerevisiae S288C 241-245 9046094-2 1997 We have discovered that low levels of glucose are required for maximal transcription of SUC2: SUC2 expression is induced about five- to ten-fold in cells growing on low levels of glucose (0.1%) compared to cells growing on galactose or glycerol. Glycerol 236-244 beta-fructofuranosidase SUC2 Saccharomyces cerevisiae S288C 88-92 9046094-2 1997 We have discovered that low levels of glucose are required for maximal transcription of SUC2: SUC2 expression is induced about five- to ten-fold in cells growing on low levels of glucose (0.1%) compared to cells growing on galactose or glycerol. Glycerol 236-244 beta-fructofuranosidase SUC2 Saccharomyces cerevisiae S288C 94-98 16526129-4 1997 The X-ray crystallographic structure of 6h bound to NA revealed the presence of a large hydrophobic pocket in the region corresponding to the glycerol subsite of sialic acid. Glycerol 142-150 neuraminidase 1 Homo sapiens 52-54 9059629-0 1997 Effects of glycerol on the kinetic properties of betaine aldehyde dehydrogenase. Glycerol 11-19 aldehyde dehydrogenase 7 family member A1 Homo sapiens 49-79 9242918-1 1997 Phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (PEPCK) is a key enzyme in the synthesis of glucose in the liver and kidney and of glyceride-glycerol in white adipose tissue and the small intestine. Glycerol 147-155 phosphoenolpyruvate carboxykinase 1, cytosolic Mus musculus 55-60 9017604-9 1997 During glycerol density gradient centrifugation, both Sun1p and Sun2p comigrated with the known proteasome components. Glycerol 7-15 Sad1 and UNC84 domain containing 1 Homo sapiens 54-59 9017604-9 1997 During glycerol density gradient centrifugation, both Sun1p and Sun2p comigrated with the known proteasome components. Glycerol 7-15 Sad1 and UNC84 domain containing 2 Homo sapiens 64-69 9434067-0 1997 Hepatocyte growth factor in glycerol-induced acute renal failure. Glycerol 28-36 hepatocyte growth factor Rattus norvegicus 0-24 9434067-2 1997 Here we investigated the HGF production in glycerol-induced ARF rats. Glycerol 43-51 hepatocyte growth factor Rattus norvegicus 25-28 9434067-3 1997 HGF mRNA expression levels were elevated in liver, spleen, and lung 6-24 h after glycerol injection. Glycerol 81-89 hepatocyte growth factor Rattus norvegicus 0-3 8824210-5 1996 In contrast, radioactive glycerol accumulated in phosphatidic acid, diacylglycerol, and triacylglycerol in cyclopentenylcytosine-treated cells compared with controls suggesting a re-routing of phospholipid biosynthesis away from CTP utilizing reactions toward neutral lipid synthesis. Glycerol 25-33 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 229-232 8985158-9 1996 The thermotolerance defect of the hsf1-m3 and ssc1-3 mutants is demonstrated for both glucose and glycerol media. Glycerol 98-106 stress-responsive transcription factor HSF1 Saccharomyces cerevisiae S288C 34-38 8985158-9 1996 The thermotolerance defect of the hsf1-m3 and ssc1-3 mutants is demonstrated for both glucose and glycerol media. Glycerol 98-106 Hsp70 family ATPase SSC1 Saccharomyces cerevisiae S288C 46-52 8994903-4 1996 The best conditions for detecting the point mutation were by using a 5% polyacrylamide gel without glycerol and loading at 3 degrees C. The RYR1 genotypes diagnosed by PCR-SSCP were identical to the genotypes diagnosed by restriction enzyme fragment length polymorphism in all cases examined (n = 606). Glycerol 99-107 ryanodine receptor 1 Sus scrofa 140-144 8945777-3 1996 The addition of glycerol enhanced the above cryoprotective effect of CF-6 and improved calcein retention up to 90%. Glycerol 16-24 ATP synthase peripheral stalk subunit F6 Homo sapiens 69-73 9077461-6 1996 Glycerol gradient centrifugation analysis showed that all the mouse MCM proteins were detected at 450-600 kDa, an indication of the sum of their calculated molecular weights from their amino acid sequences. Glycerol 0-8 minichromosome maintenance complex component 2 Homo sapiens 68-71 8910333-4 1996 Increased levels of mature CFTR (170 kDa) could be obtained for mutant H949Y when cells were grown at a lower temperature (26 degrees C) or incubated in the presence of 10% glycerol. Glycerol 173-181 CF transmembrane conductance regulator Homo sapiens 27-31 8810261-4 1996 Although both aquaporins permit water flow across the cell membrane, only AQP3 was permeable to glycerol and urea (Pgly > Pur). Glycerol 96-104 aquaporin 3 (Gill blood group) Homo sapiens 74-78 8810261-5 1996 The uptake of glycerol into oocytes expressing AQP3 was linear up to 165 mM. Glycerol 14-22 aquaporin 3 (Gill blood group) Homo sapiens 47-51 8900132-7 1996 We found that expression of the PIS1 gene was reduced when cells were grown in a medium containing glycerol and increased when grown in a medium containing galactose relative to cells grown in a glucose medium. Glycerol 99-107 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 32-36 8900132-8 1996 The glycerol-mediated repression of PIS1 gene expression required both the MCM1 gene and the MCEs, whereas the SLN1 gene was required for full galactose-mediated induction of a PIS1-lacZ reporter gene. Glycerol 4-12 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 36-40 8900132-8 1996 The glycerol-mediated repression of PIS1 gene expression required both the MCM1 gene and the MCEs, whereas the SLN1 gene was required for full galactose-mediated induction of a PIS1-lacZ reporter gene. Glycerol 4-12 transcription factor MCM1 Saccharomyces cerevisiae S288C 75-79 9568361-2 1996 In vivo, a single injection of 1 mg of ovine prolactin induces increased plasma glycerol and nonesterified fatty acids concentrations within 30 min (P < 0.01). Glycerol 80-88 prolactin Oryctolagus cuniculus 45-54 8824643-0 1996 The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans. Glycerol 64-72 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 45-49 8968951-0 1996 Influence of glycerol on the structure and redox properties of horse heart cytochrome c. Glycerol 13-21 cytochrome c, somatic Equus caballus 75-87 8968951-2 1996 The effect of glycerol on the structure and redox properties of horse heart cytochrome c was investigated by absorption spectroscopy, circular dichroism, and dc cyclic voltammetry techniques. Glycerol 14-22 cytochrome c, somatic Equus caballus 76-88 8968951-4 1996 Glycerol stabilizes cytochrome c, the free energy of denaturation (delta G0) being approximately 0.7 kcal/mol larger than that determined in phosphate buffer under the same conditions, and influences the heterogeneous electron transfer kinetics at a chemically modified gold electrode: on the other hand, the redox potential of the protein is unaltered. Glycerol 0-8 cytochrome c, somatic Equus caballus 20-32 8968951-5 1996 On the whole, the results obtained indicate that glycerol acts as a suitable stabilizing agent of cytochrome c, which is of interest for application in biotechnology: the organic solvent does not alter the tertiary structure significantly or the redox properties of the protein. Glycerol 49-57 cytochrome c, somatic Equus caballus 98-110 8953576-2 1996 When isolating synaptic vesicles by glycerol velocity gradient centrifugation we found cosedimentation of the presumptive presynaptic plasma membrane proteins syntaxin and SNAP-25 with synaptic vesicle membrane proteins. Glycerol 36-44 synaptosome associated protein 25 Homo sapiens 172-179 8905928-5 1996 On glycerol medium, where mitochondrial function is required for growth, shm1 deletion mutants are able to grow whereas shm1 abf2 double mutants are severely inhibited. Glycerol 3-11 glycine hydroxymethyltransferase SHM1 Saccharomyces cerevisiae S288C 73-77 8923738-3 1996 The glycerol yield was 4.7 times (a pdc mutant exhibiting 19% of normal PDC activity) and 6.5 times (a strain exhibiting 20-fold increased GPD activity resulting from overexpression of GPD1 gene) that of the wild type. Glycerol 4-12 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 139-142 8923738-3 1996 The glycerol yield was 4.7 times (a pdc mutant exhibiting 19% of normal PDC activity) and 6.5 times (a strain exhibiting 20-fold increased GPD activity resulting from overexpression of GPD1 gene) that of the wild type. Glycerol 4-12 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 185-189 8923738-6 1996 The rate of glycerol formation in the pdc mutant was, due to a slower rate of glucose catabolism, only twice that of the wild type, and was increased by GPD1 overexpression to three times that of the wild-type level. Glycerol 12-20 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 153-157 8923738-7 1996 Overexpression of GPD1 in the wild-type background, however, led to a six- to seven-fold increase in the rate of glycerol formation. Glycerol 113-121 glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Saccharomyces cerevisiae S288C 18-22 8923738-8 1996 The experimental work clearly demonstrates the rate-limiting role of GPD in glycerol formation in S. cerevisiae. Glycerol 76-84 glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C 69-72 8884278-1 1996 Glycerol kinase (Gyk) participates in the metabolism of endogenously derived and dietary glycerol. Glycerol 89-97 glycerol kinase Mus musculus 0-15 8884278-1 1996 Glycerol kinase (Gyk) participates in the metabolism of endogenously derived and dietary glycerol. Glycerol 89-97 glycerol kinase Mus musculus 17-20 8784081-5 1996 IFN alpha induced increases in plasma concentrations of norepinephrine (225 +/- 93%; P < 0.02 vs. control), epinephrine (272 +/- 80%; P < 0.05), cortisol (353 +/- 63%; P < 0.02), glucagon (50 +/- 12%; P < 0.05), free fatty acids (223 +/- 61%; P < 0.02), and glycerol (68 +/- 21%; P < 0.02) and in resting energy expenditure (36 +/- 50%; P < 0.03). Glycerol 273-281 interferon alpha 1 Homo sapiens 0-9 8784081-6 1996 The Ra of glycerol (169 +/- 39%; P < 0.02) and fat oxidation (104 +/- 23%, P < 0.02) were also increased after IFN alpha treatment. Glycerol 10-18 interferon alpha 1 Homo sapiens 117-126 8884526-7 1996 Two out of three specimens from negative scratch-test sites with control liquid (mixture of equal amount of saline and glycerine) showed ICAM-1 expression in a similar manner to that of the positive scratch tests. Glycerol 119-128 intercellular adhesion molecule 1 Homo sapiens 137-143 8943782-5 1996 The highly active 17 beta-HSD1 preparation was successfully crystallized in the presence of NADP-, polyethylene glycol, beta-octylglucoside and glycerol, resulting in the first diffraction quality crystals of any steroid-converting enzyme from a human source. Glycerol 144-152 hydroxysteroid 17-beta dehydrogenase 1 Homo sapiens 18-30 8872981-14 1996 In another model of oxidant-induced renal injury, the glycerol model, bcl2 mRNA was not induced at 6 and 24 hours after the administration of glycerol. Glycerol 54-62 BCL2, apoptosis regulator Rattus norvegicus 70-74 8880911-5 1996 Enhanced low-temperature stability of apoA-2 observed upon increase in Na2HPO4 concentration from 0.3 mM to 50 mM or addition of 10% glycerol may be linked to reduced water activity. Glycerol 133-141 apolipoprotein A2 Homo sapiens 38-44 8858219-12 1996 GH did not influence circulating levels of total IGF-I, C-peptide, insulin or glucose, but caused a further increase in NEFA, glycerol and 3-OH-butyrate levels, indicating enhanced lipolysis and ketogenesis. Glycerol 126-134 growth hormone 1 Homo sapiens 0-2 8877342-5 1996 This drawback has hitherto been largely underestimated, and we think that ethylene glycol results obtained with these enzymatic techniques should be interpreted with caution, even if the sample is pre-treated with glycerokinase (EC 2.7.1.30); this pre-treatment effectively corrects the glycerol interference but not that of propylene glycol. Glycerol 287-295 glycerol kinase Homo sapiens 214-227 8759865-8 1996 Enzyme-linked immunosorbent assay and glycerol density gradient sedimentation experiments suggest that MucA physically interacts with AlgT. Glycerol 38-46 MucA Escherichia coli 103-107 8760086-3 1996 ANG II (1 nM) infusion alone caused vasoconstriction with increased oxygen (55%) and glucose (98%) uptake and lactate (37%) and glycerol (64%) release. Glycerol 128-136 angiotensinogen Rattus norvegicus 0-6