PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31608994-4	2020	Among the histone modifiers, polycomb group proteins (PcGs), such as Ezh2, Eed and Suz12 form large protein complexes-polycomb repressive complex 2 (PRC2); while Ring1b and Bmi1 proteins form core of PRC1 along with accessory proteins such as Cbx, Hph, Rybp and Pcgfs catalyse histone modifications such as H3K27me3 and H2AK119ub1.	K.H.3	307-315	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	69-73
32478392-6	2020	At day 6, diseased animals treated with KH-3 showed significant reduction in glomerular HuR levels, proteinuria, podocyte injury determined by ameliorated podocyte loss and podocin expression, glomerular staining for periodic acid-Schiff positive extracellular matrix proteins, fibronectin and collagen IV and mRNA and protein levels of profibrotic markers, compared with untreated disease rats.	K.H.3	40-44	ELAV like RNA binding protein 1	Rattus norvegicus	88-91
32478392-6	2020	At day 6, diseased animals treated with KH-3 showed significant reduction in glomerular HuR levels, proteinuria, podocyte injury determined by ameliorated podocyte loss and podocin expression, glomerular staining for periodic acid-Schiff positive extracellular matrix proteins, fibronectin and collagen IV and mRNA and protein levels of profibrotic markers, compared with untreated disease rats.	K.H.3	40-44	NPHS2 stomatin family member, podocin	Rattus norvegicus	173-180
32478392-6	2020	At day 6, diseased animals treated with KH-3 showed significant reduction in glomerular HuR levels, proteinuria, podocyte injury determined by ameliorated podocyte loss and podocin expression, glomerular staining for periodic acid-Schiff positive extracellular matrix proteins, fibronectin and collagen IV and mRNA and protein levels of profibrotic markers, compared with untreated disease rats.	K.H.3	40-44	fibronectin 1	Rattus norvegicus	278-289
32067230-9	2020	Knockdown of UCA1 reduced the occupancies of the enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) and H3K27me3 on the Janus kinase 2 (JAK2) promoter regions.	K.H.3	118-126	urothelial cancer associated 1	Homo sapiens	13-17
32067230-9	2020	Knockdown of UCA1 reduced the occupancies of the enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) and H3K27me3 on the Janus kinase 2 (JAK2) promoter regions.	K.H.3	118-126	Janus kinase 2	Homo sapiens	134-148
32067230-9	2020	Knockdown of UCA1 reduced the occupancies of the enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) and H3K27me3 on the Janus kinase 2 (JAK2) promoter regions.	K.H.3	118-126	Janus kinase 2	Homo sapiens	150-154
31608994-4	2020	Among the histone modifiers, polycomb group proteins (PcGs), such as Ezh2, Eed and Suz12 form large protein complexes-polycomb repressive complex 2 (PRC2); while Ring1b and Bmi1 proteins form core of PRC1 along with accessory proteins such as Cbx, Hph, Rybp and Pcgfs catalyse histone modifications such as H3K27me3 and H2AK119ub1.	K.H.3	307-315	embryonic ectoderm development	Homo sapiens	75-78
31608994-4	2020	Among the histone modifiers, polycomb group proteins (PcGs), such as Ezh2, Eed and Suz12 form large protein complexes-polycomb repressive complex 2 (PRC2); while Ring1b and Bmi1 proteins form core of PRC1 along with accessory proteins such as Cbx, Hph, Rybp and Pcgfs catalyse histone modifications such as H3K27me3 and H2AK119ub1.	K.H.3	307-315	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	83-88
32332873-4	2020	Here, we report a HuR inhibitor KH-3, which potently suppresses breast cancer cell growth and invasion.	K.H.3	32-36	ELAV like RNA binding protein 1	Homo sapiens	18-21
31903696-10	2020	Mechanistically, we found that UNC5B-AS1 interacted with zeste 2 polycomb repressive complex 2 subunit (EZH2) to trigger trimethylation of histone H3 at lysine 27 (H3K27me3) on N-myc downstream regulated gene-2 (NDRG2) promoter and epigenetically repress NDRG2.	K.H.3	164-172	UNC5B antisense RNA 1	Homo sapiens	31-40
31903696-10	2020	Mechanistically, we found that UNC5B-AS1 interacted with zeste 2 polycomb repressive complex 2 subunit (EZH2) to trigger trimethylation of histone H3 at lysine 27 (H3K27me3) on N-myc downstream regulated gene-2 (NDRG2) promoter and epigenetically repress NDRG2.	K.H.3	164-172	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	104-108
31903696-10	2020	Mechanistically, we found that UNC5B-AS1 interacted with zeste 2 polycomb repressive complex 2 subunit (EZH2) to trigger trimethylation of histone H3 at lysine 27 (H3K27me3) on N-myc downstream regulated gene-2 (NDRG2) promoter and epigenetically repress NDRG2.	K.H.3	164-172	NDRG family member 2	Homo sapiens	177-210
31903696-10	2020	Mechanistically, we found that UNC5B-AS1 interacted with zeste 2 polycomb repressive complex 2 subunit (EZH2) to trigger trimethylation of histone H3 at lysine 27 (H3K27me3) on N-myc downstream regulated gene-2 (NDRG2) promoter and epigenetically repress NDRG2.	K.H.3	164-172	NDRG family member 2	Homo sapiens	212-217
31903696-10	2020	Mechanistically, we found that UNC5B-AS1 interacted with zeste 2 polycomb repressive complex 2 subunit (EZH2) to trigger trimethylation of histone H3 at lysine 27 (H3K27me3) on N-myc downstream regulated gene-2 (NDRG2) promoter and epigenetically repress NDRG2.	K.H.3	164-172	NDRG family member 2	Homo sapiens	255-260
31858687-0	2020	Hdac3, Setdb1, and Kap1 mark H3K9me3/H3K14ac bivalent regions in young and aged liver.	K.H.3	29-36	SET domain bifurcated histone lysine methyltransferase 1	Homo sapiens	7-13
32070418-7	2020	The alterations of H3K9me3 in the hippocampus of C9BAC mice led us to identify previously undetected neuronal loss in CA1, CA3, and dentate gyrus, as well as hippocampal-dependent cognitive deficits.	K.H.3	19-26	carbonic anhydrase 1	Mus musculus	118-121
32070418-7	2020	The alterations of H3K9me3 in the hippocampus of C9BAC mice led us to identify previously undetected neuronal loss in CA1, CA3, and dentate gyrus, as well as hippocampal-dependent cognitive deficits.	K.H.3	19-26	carbonic anhydrase 3	Mus musculus	123-126
31858687-0	2020	Hdac3, Setdb1, and Kap1 mark H3K9me3/H3K14ac bivalent regions in young and aged liver.	K.H.3	29-36	tripartite motif containing 28	Homo sapiens	19-23
31858687-0	2020	Hdac3, Setdb1, and Kap1 mark H3K9me3/H3K14ac bivalent regions in young and aged liver.	K.H.3	29-36	histone deacetylase 3	Homo sapiens	0-5
31903140-4	2020	Results: Global histone methylation analysis revealed a pronounced increase of the repressive histone trimethylation in three different cell types with mdig depletion, including trimethylation of lysines 9 and 27 on histone H3 (H3K9me3, H3K27me3) and trimethylation of lysine 20 of histone H4 (H4K20me3).	K.H.3	224-226	ribosomal oxygenase 2	Homo sapiens	152-156
31875854-8	2020	Our results suggest that the histone variant H2A.Z epigenetically regulates the licensing and activation of early replication origins and maintains replication timing through the SUV420H1-H4K20me2-ORC1 axis.	K.H.3	185-196	H2A.Z variant histone 1	Homo sapiens	45-50
31875854-8	2020	Our results suggest that the histone variant H2A.Z epigenetically regulates the licensing and activation of early replication origins and maintains replication timing through the SUV420H1-H4K20me2-ORC1 axis.	K.H.3	185-196	origin recognition complex subunit 1	Homo sapiens	197-201
31890818-3	2020	To explore the bovine functional genomic elements and the vital roles of butyrate on the epigenetic modifications of bovine genomic activities, we generated and deposited the genome-wide datasets of transcript factor binding sites of CTCF (CCCTC-binding factor, insulator binding protein), histone methylation (H3H27me3, H3K4me1, H3K4me3) and histone acetylation (H3K27ac) from bovine rumen epithelial primary cells (REPC) before and after butyrate treatment (doi: 10.1186/s12915-019-0687-8 [1]).	K.H.3	311-337	CCCTC-binding factor	Bos taurus	234-238
31662475-4	2019	The compound KH3 significantly suppressed proliferation of various PDAC cells by down-regulating the levels of glycolysis and mitochondrial respiration in correlation with PGAM1 expression.	K.H.3	13-16	phosphoglycerate mutase 1	Homo sapiens	172-177
31676321-6	2019	Furthermore, the enrichment of H3K9me3 at TSC2 promoter region was decreased and ubiquitin proteasome degradation of suv39h1 was increased.	K.H.3	31-38	TSC complex subunit 2	Homo sapiens	42-46
31610501-10	2019	ChIP results showed that H3K9ac, H3K9me3 and H3K27me3 modifications on p16 gene showed significant increases after 1 and 10 muM of BPA exposure.	K.H.3	33-40	cyclin dependent kinase inhibitor 2A	Homo sapiens	71-74
31662475-7	2019	The better responses to KH3 in PDXs were associated with higher expression of PGAM1 and longer/stronger suppressions of cancer metabolic pathways.	K.H.3	24-27	phosphoglycerate mutase 1	Homo sapiens	78-83
31631027-3	2019	We demonstrate that ATRX IFF proteins are redistributed from H3K9me3-enriched chromatin to promoters of active genes and identify REST as an ATRX IFF target whose activation promotes silencing of neuronal differentiation genes.	K.H.3	61-68	ATRX chromatin remodeler	Homo sapiens	20-24
31631027-3	2019	We demonstrate that ATRX IFF proteins are redistributed from H3K9me3-enriched chromatin to promoters of active genes and identify REST as an ATRX IFF target whose activation promotes silencing of neuronal differentiation genes.	K.H.3	61-68	ATRX chromatin remodeler	Homo sapiens	141-145
31665047-9	2019	The histone methylation level of MALAT1 promoter region (H3K9me3 and H3K36me3) was tested by ChIP-PCR assays.	K.H.3	57-64	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	33-39
31665047-15	2019	Further molecular mechanism investigation demonstrated that JMJD2C protein translocated into the nuclear, lowered the histone methylation level of MALAT1 promoter in the sites of H3K9me3 and H3K36me3, up-regulated the expression of MALAT1, and enhanced the beta-catenin signaling pathway in CRC cells.	K.H.3	179-186	lysine demethylase 4C	Homo sapiens	60-66
31665047-15	2019	Further molecular mechanism investigation demonstrated that JMJD2C protein translocated into the nuclear, lowered the histone methylation level of MALAT1 promoter in the sites of H3K9me3 and H3K36me3, up-regulated the expression of MALAT1, and enhanced the beta-catenin signaling pathway in CRC cells.	K.H.3	179-186	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	147-153
31720078-1	2019	Enhancer of zeste homolog 2 (EZH2) mediates epigenetic gene silencing via tri-methylation of histone H3 lysine 27 (H3K27-me3).	K.H.3	115-124	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-27
31720078-1	2019	Enhancer of zeste homolog 2 (EZH2) mediates epigenetic gene silencing via tri-methylation of histone H3 lysine 27 (H3K27-me3).	K.H.3	115-124	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
31551408-7	2019	Furthermore, binding of DNMT1, DNMT3B, and EZH2 to the promoter region of p16INK4A decreased in PM2.5-treated keratinocytes, whereas TET1 and MLL1 binding increased, leading to decreased histone H3 lysine 27 trimethylation (H3K27Me3) and increased H3K4Me3 in the promoter of p16INK4A.	K.H.3	224-232	DNA methyltransferase 1	Homo sapiens	24-29
31551408-7	2019	Furthermore, binding of DNMT1, DNMT3B, and EZH2 to the promoter region of p16INK4A decreased in PM2.5-treated keratinocytes, whereas TET1 and MLL1 binding increased, leading to decreased histone H3 lysine 27 trimethylation (H3K27Me3) and increased H3K4Me3 in the promoter of p16INK4A.	K.H.3	224-232	cyclin dependent kinase inhibitor 2A	Homo sapiens	74-82
17437720-3	2007	We show that KH3 and KH4 behave as independent binding modules and can interact with different regions of the AU-rich RNA targets of KSRP.	K.H.3	13-16	KH-type splicing regulatory protein	Homo sapiens	133-137
35637281-7	2022	The KH3 and KH4 domains of FUBP3 are the critical sites for binding to lnc-EST12.	K.H.3	4-7	far upstream element (FUSE) binding protein 3	Mus musculus	27-32
31640975-8	2019	Moreover, PIASy overexpression leads to increased trimethylation of histone H3 lysine 9 (H3K9me3) in two-cell nuclei and enhanced translocation of H3K9me3 methyltransferase to the pronucleus.	K.H.3	89-96	protein inhibitor of activated STAT 4	Homo sapiens	10-15
31640975-8	2019	Moreover, PIASy overexpression leads to increased trimethylation of histone H3 lysine 9 (H3K9me3) in two-cell nuclei and enhanced translocation of H3K9me3 methyltransferase to the pronucleus.	K.H.3	147-154	protein inhibitor of activated STAT 4	Homo sapiens	10-15
27387282-6	2016	KH2 and KH3 bind adjacently to an IRES subdomain (d10b) that is unrelated to dIV, with KH3 in an inverted orientation.	K.H.3	87-90	potassium voltage-gated channel modifier subfamily G member 1	Homo sapiens	0-3