PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32615350-10	2020	Altogether, these data support that similar to interactions between PAHs, mixtures of PAHs and oxy-PAHs may cause increased developmental and cardiovascular toxicity in ZFEs through an AhR-dependent mechanism.	oxy-pahs	95-103	aryl hydrocarbon receptor 1a	Danio rerio	185-188
11764156-7	2001	The only oxy-PAHs with detectable levels of in vitro AhR-mediated activity were benzanthrone and benz[a]anthracene-7,12-dione.	oxy-pahs	9-17	aryl hydrocarbon receptor	Homo sapiens	53-56
32527278-9	2020	As expected, electrophysiological instability was induced higher in oxy-PAHs (9,10-anthraquinone, AQ or 7,12-benz(a) anthraquinone, BAQ)-treated cardiomyocytes than in PAHs (anthracene, ANT or benz(a) anthracene, BaA)-treated cardiomyocytes; oxy-PAHs infusion of cells mediated by aryl hydrocarbon receptor (AhR) was faster than PAHs infusion.	oxy-pahs	68-76	solute carrier family 25 member 6	Homo sapiens	186-189
32554275-9	2020	Toxicological results revealed that indoor and personal exposure to OC as well as PAH compounds and their derivatives (e.g., Alkyl-PAHs, Oxy-PAHs) induced cell viability reduction and increase in levels of LDH, IL-6, and 8-isoprostane.	oxy-pahs	137-145	interleukin 6	Homo sapiens	211-215
32527278-9	2020	As expected, electrophysiological instability was induced higher in oxy-PAHs (9,10-anthraquinone, AQ or 7,12-benz(a) anthraquinone, BAQ)-treated cardiomyocytes than in PAHs (anthracene, ANT or benz(a) anthracene, BaA)-treated cardiomyocytes; oxy-PAHs infusion of cells mediated by aryl hydrocarbon receptor (AhR) was faster than PAHs infusion.	oxy-pahs	68-76	aryl hydrocarbon receptor	Homo sapiens	281-306
32527278-9	2020	As expected, electrophysiological instability was induced higher in oxy-PAHs (9,10-anthraquinone, AQ or 7,12-benz(a) anthraquinone, BAQ)-treated cardiomyocytes than in PAHs (anthracene, ANT or benz(a) anthracene, BaA)-treated cardiomyocytes; oxy-PAHs infusion of cells mediated by aryl hydrocarbon receptor (AhR) was faster than PAHs infusion.	oxy-pahs	68-76	aryl hydrocarbon receptor	Homo sapiens	308-311
31397158-5	2019	Interleukin (IL)-6 was associated with Oxy-PAHs of 1,8-naphthalic anhydride, xanthone, and benzo[h]quinolone, especially, whereas IL-1beta and tumor necrosis factor (TNF)-alpha were associated with most species.	oxy-pahs	39-47	interleukin 6	Homo sapiens	0-18
30090389-3	2016	In this study, the effects of 15 environmentally relevant oxy-PAHs on the induction and activity of the CYP1 enzymes were determined in vitro by measuring gene expression levels and enzyme activity.	oxy-pahs	58-66	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	104-108
26656082-5	2016	In addition, clear mRNA expression of CYP1A1, which is associated with aryl hydrocarbon receptor (AhR)-mediated activation, was observed following the exposure of cells to two PAHs (B[k]FA and B[b]FA) and three oxy-PAHs (1,2-naphthoquinone, 11H-benzo[b]fluoren-11-one and BPO).	oxy-pahs	211-219	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	38-44
26656082-5	2016	In addition, clear mRNA expression of CYP1A1, which is associated with aryl hydrocarbon receptor (AhR)-mediated activation, was observed following the exposure of cells to two PAHs (B[k]FA and B[b]FA) and three oxy-PAHs (1,2-naphthoquinone, 11H-benzo[b]fluoren-11-one and BPO).	oxy-pahs	211-219	aryl-hydrocarbon receptor	Mus musculus	71-96
26656082-5	2016	In addition, clear mRNA expression of CYP1A1, which is associated with aryl hydrocarbon receptor (AhR)-mediated activation, was observed following the exposure of cells to two PAHs (B[k]FA and B[b]FA) and three oxy-PAHs (1,2-naphthoquinone, 11H-benzo[b]fluoren-11-one and BPO).	oxy-pahs	211-219	aryl-hydrocarbon receptor	Mus musculus	98-101
30851530-3	2019	In this study, we developed a new method for the detection of particle-bound PAHs, nitro-PAHs and oxy-PAHs using direct infusion into an atmospheric pressure photoionisation high-resolution mass spectrometer (APPI-HRMS).	oxy-pahs	98-106	amyloid beta precursor protein	Homo sapiens	209-213
30616058-6	2019	The genotoxic potency was confirmed in both HBEC and HepG2 cells following exposure to oxy-PAHs by an increased level of phospho-Chk1, a biomarker used to estimate the carcinogenic potency of PAHs in vitro.	oxy-pahs	87-95	checkpoint kinase 1	Homo sapiens	129-133
30090389-8	2016	These data represent the first demonstration that oxy-PAHs can be potent inhibitors of CYP1 expression and function and make important contributions towards understanding the mechanisms through which oxy-PAHs can contribute to the overall risk of polycyclic aromatic compounds.	oxy-pahs	50-58	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-91
30090389-8	2016	These data represent the first demonstration that oxy-PAHs can be potent inhibitors of CYP1 expression and function and make important contributions towards understanding the mechanisms through which oxy-PAHs can contribute to the overall risk of polycyclic aromatic compounds.	oxy-pahs	200-208	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-91
30090389-4	2016	We found that nine of the tested oxy-PAHs significantly induced CYP1A1 and CYP1B1 gene expression in human keratinocytes (HaCaT cells) while only five of these also were potent inducers of CYP1-dependent ethoxyresorufin-O-deethylase (EROD) activity suggesting that some of the oxy-PAHs are both activators of AHR signalling and inhibitors of CYP1 function.	oxy-pahs	33-41	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	64-70
30090389-4	2016	We found that nine of the tested oxy-PAHs significantly induced CYP1A1 and CYP1B1 gene expression in human keratinocytes (HaCaT cells) while only five of these also were potent inducers of CYP1-dependent ethoxyresorufin-O-deethylase (EROD) activity suggesting that some of the oxy-PAHs are both activators of AHR signalling and inhibitors of CYP1 function.	oxy-pahs	33-41	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	75-81
30090389-4	2016	We found that nine of the tested oxy-PAHs significantly induced CYP1A1 and CYP1B1 gene expression in human keratinocytes (HaCaT cells) while only five of these also were potent inducers of CYP1-dependent ethoxyresorufin-O-deethylase (EROD) activity suggesting that some of the oxy-PAHs are both activators of AHR signalling and inhibitors of CYP1 function.	oxy-pahs	33-41	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	64-68
30090389-4	2016	We found that nine of the tested oxy-PAHs significantly induced CYP1A1 and CYP1B1 gene expression in human keratinocytes (HaCaT cells) while only five of these also were potent inducers of CYP1-dependent ethoxyresorufin-O-deethylase (EROD) activity suggesting that some of the oxy-PAHs are both activators of AHR signalling and inhibitors of CYP1 function.	oxy-pahs	33-41	aryl hydrocarbon receptor	Homo sapiens	309-312
30090389-4	2016	We found that nine of the tested oxy-PAHs significantly induced CYP1A1 and CYP1B1 gene expression in human keratinocytes (HaCaT cells) while only five of these also were potent inducers of CYP1-dependent ethoxyresorufin-O-deethylase (EROD) activity suggesting that some of the oxy-PAHs are both activators of AHR signalling and inhibitors of CYP1 function.	oxy-pahs	33-41	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	75-79
30090389-5	2016	Using a recombinant human CYP1A1 enzyme we showed that eleven of the oxy-PAHs potently inhibited enzyme activity with benz[a]anthracene-7,12-quinone (7,12-BAQ) and benzo[a]fluorenone (BFLO) being the most potent inhibitors (IC50 = 0.037 and 0.061 muM, respectively).	oxy-pahs	69-77	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	26-32
30090389-7	2016	The results showed that oxy-PAHs can interfere with the TCDD-mediated effects leading to reduced CYP1A1 and 1B1 expression and EROD activity.	oxy-pahs	24-32	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	97-111