PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24887566-0	2014	Mollugin induces tumor cell apoptosis and autophagy via the PI3K/AKT/mTOR/p70S6K and ERK signaling pathways.	rubimaillin	0-8	AKT serine/threonine kinase 1	Homo sapiens	65-68
24887566-0	2014	Mollugin induces tumor cell apoptosis and autophagy via the PI3K/AKT/mTOR/p70S6K and ERK signaling pathways.	rubimaillin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	69-73
24887566-0	2014	Mollugin induces tumor cell apoptosis and autophagy via the PI3K/AKT/mTOR/p70S6K and ERK signaling pathways.	rubimaillin	0-8	ribosomal protein S6 kinase B1	Homo sapiens	74-80
23065756-0	2013	Mollugin inhibits proliferation and induces apoptosis by suppressing fatty acid synthase in HER2-overexpressing cancer cells.	rubimaillin	0-8	erb-b2 receptor tyrosine kinase 2	Homo sapiens	92-96
23466342-4	2013	Mollugin treatment also significantly increased intracellular accumulation of the fluorescently-tagged P-gp substrate, rhodamine-123.	rubimaillin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	103-107
23065756-3	2013	Our results showed that mollugin exhibited potent inhibitory effects on cancer cell proliferation, especially in HER2-overexpressing SK-BR-3 human breast cancer cells and SK-OV-3 human ovarian cancer cells in a dose- and time-dependent manner without affecting immortalized normal mammary epithelial cell line MCF-10A.	rubimaillin	24-32	erb-b2 receptor tyrosine kinase 2	Homo sapiens	113-117
23065756-4	2013	Furthermore, we found that a blockade of Akt/SREBP-1c signaling through mollugin treatment significantly reduced FAS expression and subsequently suppressed cell proliferation and induced apoptosis in HER2-overexpressing cancer cells.	rubimaillin	72-80	AKT serine/threonine kinase 1	Homo sapiens	41-44
23065756-4	2013	Furthermore, we found that a blockade of Akt/SREBP-1c signaling through mollugin treatment significantly reduced FAS expression and subsequently suppressed cell proliferation and induced apoptosis in HER2-overexpressing cancer cells.	rubimaillin	72-80	sterol regulatory element binding transcription factor 1	Homo sapiens	45-53
23065756-4	2013	Furthermore, we found that a blockade of Akt/SREBP-1c signaling through mollugin treatment significantly reduced FAS expression and subsequently suppressed cell proliferation and induced apoptosis in HER2-overexpressing cancer cells.	rubimaillin	72-80	erb-b2 receptor tyrosine kinase 2	Homo sapiens	200-204
23065756-7	2013	These data provide evidence that mollugin inhibits proliferation and induces apoptosis in HER2-overexpressing cancer cells by blocking expression of the FAS gene through modulation of a HER2/Akt/SREBP-1c signaling pathway.	rubimaillin	33-41	erb-b2 receptor tyrosine kinase 2	Homo sapiens	90-94
23065756-7	2013	These data provide evidence that mollugin inhibits proliferation and induces apoptosis in HER2-overexpressing cancer cells by blocking expression of the FAS gene through modulation of a HER2/Akt/SREBP-1c signaling pathway.	rubimaillin	33-41	erb-b2 receptor tyrosine kinase 2	Homo sapiens	186-190
23065756-7	2013	These data provide evidence that mollugin inhibits proliferation and induces apoptosis in HER2-overexpressing cancer cells by blocking expression of the FAS gene through modulation of a HER2/Akt/SREBP-1c signaling pathway.	rubimaillin	33-41	AKT serine/threonine kinase 1	Homo sapiens	191-194
23065756-7	2013	These data provide evidence that mollugin inhibits proliferation and induces apoptosis in HER2-overexpressing cancer cells by blocking expression of the FAS gene through modulation of a HER2/Akt/SREBP-1c signaling pathway.	rubimaillin	33-41	sterol regulatory element binding transcription factor 1	Homo sapiens	195-203
23065756-8	2013	Our findings suggest that mollugin is a novel modulator of the HER2 pathway in HER2-overexpressing cancer cells with a potential role in the treatment and prevention of human breast and ovarian cancer with HER2 overexpression.	rubimaillin	26-34	erb-b2 receptor tyrosine kinase 2	Homo sapiens	63-67
23065756-8	2013	Our findings suggest that mollugin is a novel modulator of the HER2 pathway in HER2-overexpressing cancer cells with a potential role in the treatment and prevention of human breast and ovarian cancer with HER2 overexpression.	rubimaillin	26-34	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-83
23065756-8	2013	Our findings suggest that mollugin is a novel modulator of the HER2 pathway in HER2-overexpressing cancer cells with a potential role in the treatment and prevention of human breast and ovarian cancer with HER2 overexpression.	rubimaillin	26-34	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-83
23738323-4	2013	Mollugin-induced cell death involved apoptosis, characterized by the appearance of nuclear shrinkage, flow cytometric analysis of sub-G1 phase arrest, and annexin V-FITC and propidium iodide staining.	rubimaillin	0-8	annexin A5	Homo sapiens	155-164
23738323-6	2013	Furthermore, mollugin induced the activation of p38, ERK, and JNK and the expression of heme oxygenase-1 (HO-1) and nuclear factor E2-related factor 2 (Nrf2).	rubimaillin	13-21	mitogen-activated protein kinase 14	Homo sapiens	48-51
23738323-6	2013	Furthermore, mollugin induced the activation of p38, ERK, and JNK and the expression of heme oxygenase-1 (HO-1) and nuclear factor E2-related factor 2 (Nrf2).	rubimaillin	13-21	mitogen-activated protein kinase 1	Homo sapiens	53-56
23738323-6	2013	Furthermore, mollugin induced the activation of p38, ERK, and JNK and the expression of heme oxygenase-1 (HO-1) and nuclear factor E2-related factor 2 (Nrf2).	rubimaillin	13-21	mitogen-activated protein kinase 8	Homo sapiens	62-65
23738323-6	2013	Furthermore, mollugin induced the activation of p38, ERK, and JNK and the expression of heme oxygenase-1 (HO-1) and nuclear factor E2-related factor 2 (Nrf2).	rubimaillin	13-21	heme oxygenase 1	Homo sapiens	88-104
23738323-6	2013	Furthermore, mollugin induced the activation of p38, ERK, and JNK and the expression of heme oxygenase-1 (HO-1) and nuclear factor E2-related factor 2 (Nrf2).	rubimaillin	13-21	heme oxygenase 1	Homo sapiens	106-110
23738323-6	2013	Furthermore, mollugin induced the activation of p38, ERK, and JNK and the expression of heme oxygenase-1 (HO-1) and nuclear factor E2-related factor 2 (Nrf2).	rubimaillin	13-21	NFE2 like bZIP transcription factor 2	Homo sapiens	152-156
23738323-7	2013	Mollugin-induced growth inhibition and apoptosis of HO-1 were reversed by an HO-1 inhibitor and Nrf2 siRNA.	rubimaillin	0-8	heme oxygenase 1	Homo sapiens	52-56
23738323-7	2013	Mollugin-induced growth inhibition and apoptosis of HO-1 were reversed by an HO-1 inhibitor and Nrf2 siRNA.	rubimaillin	0-8	heme oxygenase 1	Homo sapiens	77-81
23738323-7	2013	Mollugin-induced growth inhibition and apoptosis of HO-1 were reversed by an HO-1 inhibitor and Nrf2 siRNA.	rubimaillin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	96-100
23738323-8	2013	Collectively, this is the first report to demonstrate the effectiveness of mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upregulation of the HO-1 and Nrf2 pathways and the downregulation of NF- kappa B.	rubimaillin	75-83	heme oxygenase 1	Homo sapiens	165-169
23738323-8	2013	Collectively, this is the first report to demonstrate the effectiveness of mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upregulation of the HO-1 and Nrf2 pathways and the downregulation of NF- kappa B.	rubimaillin	75-83	NFE2 like bZIP transcription factor 2	Homo sapiens	174-178
23738323-8	2013	Collectively, this is the first report to demonstrate the effectiveness of mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upregulation of the HO-1 and Nrf2 pathways and the downregulation of NF- kappa B.	rubimaillin	75-83	nuclear factor kappa B subunit 1	Homo sapiens	214-225
19716835-0	2009	Mollugin induces apoptosis in human Jurkat T cells through endoplasmic reticulum stress-mediated activation of JNK and caspase-12 and subsequent activation of mitochondria-dependent caspase cascade regulated by Bcl-xL.	rubimaillin	0-8	mitogen-activated protein kinase 8	Homo sapiens	111-114
23000442-0	2013	Selective inhibitory effects of mollugin on CYP1A2 in human liver microsomes.	rubimaillin	32-40	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	44-50
23000442-3	2013	Incubation of isoform-specific substrate probes CYPs with mollugin (0-25muM) in HLM resulted in strong inhibition of CYP1A2-catalyzed phenacetin O-deethylation, showing IC(50) values of 1.03 and 3.55muM without and with pre-incubation, respectively.	rubimaillin	58-66	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	117-123
19716835-0	2009	Mollugin induces apoptosis in human Jurkat T cells through endoplasmic reticulum stress-mediated activation of JNK and caspase-12 and subsequent activation of mitochondria-dependent caspase cascade regulated by Bcl-xL.	rubimaillin	0-8	BCL2 like 1	Homo sapiens	211-217
19716835-6	2009	These results demonstrated that mollugin-induced cytotoxicity in Jurkat T cells was mainly attributable to apoptosis provoked via endoplasmic reticulum (ER) stress-mediated activation of JNK and caspase-12, and subsequent mitochondria-dependent activation of caspase-9 and -3, leading to activation of caspase-7 and -8, which could be regulated by Bcl-xL.	rubimaillin	32-40	mitogen-activated protein kinase 8	Homo sapiens	187-190
19716835-6	2009	These results demonstrated that mollugin-induced cytotoxicity in Jurkat T cells was mainly attributable to apoptosis provoked via endoplasmic reticulum (ER) stress-mediated activation of JNK and caspase-12, and subsequent mitochondria-dependent activation of caspase-9 and -3, leading to activation of caspase-7 and -8, which could be regulated by Bcl-xL.	rubimaillin	32-40	caspase 9	Homo sapiens	259-275
19716835-6	2009	These results demonstrated that mollugin-induced cytotoxicity in Jurkat T cells was mainly attributable to apoptosis provoked via endoplasmic reticulum (ER) stress-mediated activation of JNK and caspase-12, and subsequent mitochondria-dependent activation of caspase-9 and -3, leading to activation of caspase-7 and -8, which could be regulated by Bcl-xL.	rubimaillin	32-40	caspase 7	Homo sapiens	302-318
19716835-6	2009	These results demonstrated that mollugin-induced cytotoxicity in Jurkat T cells was mainly attributable to apoptosis provoked via endoplasmic reticulum (ER) stress-mediated activation of JNK and caspase-12, and subsequent mitochondria-dependent activation of caspase-9 and -3, leading to activation of caspase-7 and -8, which could be regulated by Bcl-xL.	rubimaillin	32-40	BCL2 like 1	Homo sapiens	348-354
32908872-0	2020	Retracted: Involvement of Nrf2-Mediated Upregulation of Heme Oxygenase-1 in Mollugin-Induced Growth Inhibition and Apoptosis in Human Oral Cancer Cells.	rubimaillin	76-84	NFE2 like bZIP transcription factor 2	Homo sapiens	26-30
19652367-3	2009	Moreover, rubimaillin inhibited acyl-CoA:cholesterol acyltransferase (ACAT1) activity in ACAT1-expressing cells (IC(50): 80 microM).	rubimaillin	10-21	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	70-75
19652367-3	2009	Moreover, rubimaillin inhibited acyl-CoA:cholesterol acyltransferase (ACAT1) activity in ACAT1-expressing cells (IC(50): 80 microM).	rubimaillin	10-21	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	89-94
19652367-4	2009	Thus, these data strongly suggest that rubimaillin inhibits macrophage ACAT activity in order to decrease cholesteryl ester (CE) synthesis, leading to a reduction in the number of lipid droplets.	rubimaillin	39-50	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	71-75
19652367-5	2009	Furthermore, rubimaillin was found to inhibit the ACAT2 isozyme in ACAT2-expressing cells (IC(50): 22 microM).	rubimaillin	13-24	acetyl-Coenzyme A acetyltransferase 2	Mus musculus	50-55
19652367-5	2009	Furthermore, rubimaillin was found to inhibit the ACAT2 isozyme in ACAT2-expressing cells (IC(50): 22 microM).	rubimaillin	13-24	acetyl-Coenzyme A acetyltransferase 2	Mus musculus	67-72
19652367-6	2009	We concluded that rubimaillin is a dual inhibitor of ACAT1 and ACAT2, but is more selective for the ACAT2 isozyme.	rubimaillin	18-29	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	53-58
19652367-6	2009	We concluded that rubimaillin is a dual inhibitor of ACAT1 and ACAT2, but is more selective for the ACAT2 isozyme.	rubimaillin	18-29	acetyl-Coenzyme A acetyltransferase 2	Mus musculus	63-68
19652367-6	2009	We concluded that rubimaillin is a dual inhibitor of ACAT1 and ACAT2, but is more selective for the ACAT2 isozyme.	rubimaillin	18-29	acetyl-Coenzyme A acetyltransferase 2	Mus musculus	100-105
35007525-6	2022	Comet assay demonstrated that mollugin induced DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX.	rubimaillin	30-38	H2A.X variant histone	Homo sapiens	120-124
35007525-7	2022	In addition, mollugin induced changes in cyclin A2 and CDK2.	rubimaillin	13-21	cyclin A2	Homo sapiens	41-50
35007525-7	2022	In addition, mollugin induced changes in cyclin A2 and CDK2.	rubimaillin	13-21	cyclin dependent kinase 2	Homo sapiens	55-59
33123905-11	2020	The overproduction of IL-1beta and TNF-alpha was remarkably inhibited by mollugin treatment at doses of 20 and 40 mg/kg (P<0.05).	rubimaillin	73-81	interleukin 1 alpha	Mus musculus	22-30
33123905-11	2020	The overproduction of IL-1beta and TNF-alpha was remarkably inhibited by mollugin treatment at doses of 20 and 40 mg/kg (P<0.05).	rubimaillin	73-81	tumor necrosis factor	Mus musculus	35-44
33123905-12	2020	Additionally, the levels of TLR4 in colon tissues were significantly reduced in mollugin-treated groups compared with the DSS group.	rubimaillin	80-88	toll-like receptor 4	Mus musculus	28-32
32908872-0	2020	Retracted: Involvement of Nrf2-Mediated Upregulation of Heme Oxygenase-1 in Mollugin-Induced Growth Inhibition and Apoptosis in Human Oral Cancer Cells.	rubimaillin	76-84	heme oxygenase 1	Homo sapiens	56-72
32415939-0	2020	Rubimaillin suppresses proliferation, migration and invasion of prostate cancer cells via the Notch-1/MMP signaling pathway.	rubimaillin	0-11	notch receptor 1	Homo sapiens	94-101
32415939-0	2020	Rubimaillin suppresses proliferation, migration and invasion of prostate cancer cells via the Notch-1/MMP signaling pathway.	rubimaillin	0-11	matrix metallopeptidase 2	Homo sapiens	102-105
31880521-4	2019	Western blot assay was used to determine the effect of rubimaillin on the expressions of Bcl-2, Bax, PARP, cleaved PARP, caspase3, cleaved caspase3, and other apoptosis-related proteins in SKOV-3 cells.	rubimaillin	55-66	BCL2 apoptosis regulator	Homo sapiens	89-94
31880521-4	2019	Western blot assay was used to determine the effect of rubimaillin on the expressions of Bcl-2, Bax, PARP, cleaved PARP, caspase3, cleaved caspase3, and other apoptosis-related proteins in SKOV-3 cells.	rubimaillin	55-66	BCL2 associated X, apoptosis regulator	Homo sapiens	96-99
31880521-4	2019	Western blot assay was used to determine the effect of rubimaillin on the expressions of Bcl-2, Bax, PARP, cleaved PARP, caspase3, cleaved caspase3, and other apoptosis-related proteins in SKOV-3 cells.	rubimaillin	55-66	collagen type XI alpha 2 chain	Homo sapiens	101-105
31880521-4	2019	Western blot assay was used to determine the effect of rubimaillin on the expressions of Bcl-2, Bax, PARP, cleaved PARP, caspase3, cleaved caspase3, and other apoptosis-related proteins in SKOV-3 cells.	rubimaillin	55-66	collagen type XI alpha 2 chain	Homo sapiens	115-119
31880521-4	2019	Western blot assay was used to determine the effect of rubimaillin on the expressions of Bcl-2, Bax, PARP, cleaved PARP, caspase3, cleaved caspase3, and other apoptosis-related proteins in SKOV-3 cells.	rubimaillin	55-66	caspase 3	Homo sapiens	121-129
30110934-3	2018	The 2-(4-morpholinyl)-ethyl ester of CF3-substituted mollugin (compound 15c) showed good water solubility, improved metabolic and plasma stability, and greater inhibitory activity than mesalazine in both the TNF-alpha- and IL-6-induced colonic epithelial cell adhesion assays, suggesting that 15c is a potential anti-inflammatory agent.	rubimaillin	53-61	tumor necrosis factor	Homo sapiens	208-217
30110934-3	2018	The 2-(4-morpholinyl)-ethyl ester of CF3-substituted mollugin (compound 15c) showed good water solubility, improved metabolic and plasma stability, and greater inhibitory activity than mesalazine in both the TNF-alpha- and IL-6-induced colonic epithelial cell adhesion assays, suggesting that 15c is a potential anti-inflammatory agent.	rubimaillin	53-61	interleukin 6	Homo sapiens	223-227
28933726-6	2017	Moreover, mollugin inhibited TNF-alpha-induced phosphorylation and nuclear translocation of p65, phosphorylation and degradation of inhibitor of kappaB (IkappaBalpha), and IkappaB kinase (IKK) phosphorylation.	rubimaillin	10-18	tumor necrosis factor	Homo sapiens	29-38
28933726-6	2017	Moreover, mollugin inhibited TNF-alpha-induced phosphorylation and nuclear translocation of p65, phosphorylation and degradation of inhibitor of kappaB (IkappaBalpha), and IkappaB kinase (IKK) phosphorylation.	rubimaillin	10-18	RELA proto-oncogene, NF-kB subunit	Homo sapiens	92-95
28933726-6	2017	Moreover, mollugin inhibited TNF-alpha-induced phosphorylation and nuclear translocation of p65, phosphorylation and degradation of inhibitor of kappaB (IkappaBalpha), and IkappaB kinase (IKK) phosphorylation.	rubimaillin	10-18	NFKB inhibitor alpha	Homo sapiens	153-165