PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34944918-8	2021	Lastly, treatment with soluble sKL prolonged survival of Pdx1-Cre; KrasG12D/+;Trp53R172H/+ (KPC) mice, a model known to recapitulate human PDAC.	skl	31-34	pancreatic and duodenal homeobox 1	Mus musculus	57-61
34944918-8	2021	Lastly, treatment with soluble sKL prolonged survival of Pdx1-Cre; KrasG12D/+;Trp53R172H/+ (KPC) mice, a model known to recapitulate human PDAC.	skl	31-34	transformation related protein 53	Mus musculus	78-83
34944918-10	2021	Furthermore, these data suggest that the levels of klotho expression and DNA methylation could have prognostic value in PDAC patients, and that administration of exogenous sKL may serve as a novel therapeutic strategy to treat PDAC.	skl	172-175	klotho	Homo sapiens	51-57
31536138-4	2020	We find that sKL induces the expression of EGR-1 mRNA and protein.	skl	13-16	early growth response 1	Mus musculus	43-48
31536138-6	2020	Additionally, sKL induces the expression of markers of bone differentiation (BMP2, RUNX2, ALP, COL1A, and osteocalcin) in osteoblast MC3T3 cells.	skl	14-17	bone morphogenetic protein 2	Mus musculus	77-81
31536138-6	2020	Additionally, sKL induces the expression of markers of bone differentiation (BMP2, RUNX2, ALP, COL1A, and osteocalcin) in osteoblast MC3T3 cells.	skl	14-17	runt related transcription factor 2	Mus musculus	83-88
31536138-6	2020	Additionally, sKL induces the expression of markers of bone differentiation (BMP2, RUNX2, ALP, COL1A, and osteocalcin) in osteoblast MC3T3 cells.	skl	14-17	bone gamma-carboxyglutamate protein 2	Mus musculus	106-117
31536138-7	2020	EGR-1 siRNA decreases the bone mineralization induced by sKL or ascorbic acid/glycerol 2-phosphate in MC3T3 cells.	skl	57-60	early growth response 1	Mus musculus	0-5
29632215-4	2018	sKL induced FGF23 signaling in bone and exacerbated the hypomineralization without exacerbating the hyperphosphatemia, hypercalcemia and hypervitaminosis D in kl/kl mice.	skl	0-3	fibroblast growth factor 23	Mus musculus	12-17
19615321-11	2009	CONCLUSION: Renal injury can be postponed and improved when treated with SKL plus prednisone; it may contribute to the depression of abnormal activation of NF-kappaB, and the inhibition of production of TNF-alpha and NO.	skl	73-76	tumor necrosis factor	Rattus norvegicus	203-212
34079811-2	2021	We assessed the relationship between serum soluble Klotho (sKL) level and outcome in MHD patients.	skl	59-62	klotho	Homo sapiens	51-57
35597178-6	2022	Therefore, in this study, we demonstrated that serum soluble Klotho (sKL) could exert its cardioprotective and anti-inflammatory effects by regulating the phenotype of macrophages by inhibiting TLR4/MyD88/NF-kappaB.	skl	69-72	klotho	Mus musculus	61-67
35597178-6	2022	Therefore, in this study, we demonstrated that serum soluble Klotho (sKL) could exert its cardioprotective and anti-inflammatory effects by regulating the phenotype of macrophages by inhibiting TLR4/MyD88/NF-kappaB.	skl	69-72	toll-like receptor 4	Mus musculus	194-198
35597178-6	2022	Therefore, in this study, we demonstrated that serum soluble Klotho (sKL) could exert its cardioprotective and anti-inflammatory effects by regulating the phenotype of macrophages by inhibiting TLR4/MyD88/NF-kappaB.	skl	69-72	myeloid differentiation primary response gene 88	Mus musculus	199-204
35597178-6	2022	Therefore, in this study, we demonstrated that serum soluble Klotho (sKL) could exert its cardioprotective and anti-inflammatory effects by regulating the phenotype of macrophages by inhibiting TLR4/MyD88/NF-kappaB.	skl	69-72	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	205-214
35597178-9	2022	Therefore, supplementation of sKL can improve aging cardiac function, reduce cardiac oxidative stress, inflammation and apoptosis by promoting M2a/M2c polarized macrophages via inhibiting the TLR4/Myd88/NF-kappaB pathway.	skl	30-33	toll-like receptor 4	Mus musculus	192-196
35597178-9	2022	Therefore, supplementation of sKL can improve aging cardiac function, reduce cardiac oxidative stress, inflammation and apoptosis by promoting M2a/M2c polarized macrophages via inhibiting the TLR4/Myd88/NF-kappaB pathway.	skl	30-33	myeloid differentiation primary response gene 88	Mus musculus	197-202
35597178-9	2022	Therefore, supplementation of sKL can improve aging cardiac function, reduce cardiac oxidative stress, inflammation and apoptosis by promoting M2a/M2c polarized macrophages via inhibiting the TLR4/Myd88/NF-kappaB pathway.	skl	30-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	203-212
35527141-2	2022	In this study, SKL (secreted KL) and heparin were cross-linked to the acellular small intestinal submucosa (SIS).	skl	15-18	klotho	Homo sapiens	29-31
35527141-7	2022	SKL treatment promoted endothelial cells proliferation and upregulated the levels of Focal adhesion kinase (FAK) phosphorylation and Ras homolog gene family, member A (RhoA).	skl	0-3	protein tyrosine kinase 2	Homo sapiens	85-106
35527141-7	2022	SKL treatment promoted endothelial cells proliferation and upregulated the levels of Focal adhesion kinase (FAK) phosphorylation and Ras homolog gene family, member A (RhoA).	skl	0-3	protein tyrosine kinase 2	Homo sapiens	108-111
35527141-7	2022	SKL treatment promoted endothelial cells proliferation and upregulated the levels of Focal adhesion kinase (FAK) phosphorylation and Ras homolog gene family, member A (RhoA).	skl	0-3	ras homolog family member D	Homo sapiens	133-166
35527141-7	2022	SKL treatment promoted endothelial cells proliferation and upregulated the levels of Focal adhesion kinase (FAK) phosphorylation and Ras homolog gene family, member A (RhoA).	skl	0-3	ras homolog family member A	Homo sapiens	168-172