PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18239617-5	2008	Functionally, histamine and H(4)R agonists clobenpropit and 4-methylhistamine downregulated the production of the Th2-linked chemokine CCL2 and the Th1 cytokine IL-12 on Mo-IDEC, whereas agonists for the other histamine receptors did not.	clobenpropit	43-55	histamine receptor H4	Homo sapiens	28-33
18550011-3	2008	The topical application of a histamine H3 receptor antagonist, clobenpropit, into the nasal cavities resulted in a dose-dependent increase in sneezing and nasal rubbing, and both Sch 50971 and a tachykinin NK1 receptor antagonist, L-733,060, inhibited these reactions in non-sensitized mice.	clobenpropit	63-75	histamine receptor H3	Mus musculus	29-50
18239617-5	2008	Functionally, histamine and H(4)R agonists clobenpropit and 4-methylhistamine downregulated the production of the Th2-linked chemokine CCL2 and the Th1 cytokine IL-12 on Mo-IDEC, whereas agonists for the other histamine receptors did not.	clobenpropit	43-55	C-C motif chemokine ligand 2	Homo sapiens	135-139
18239617-5	2008	Functionally, histamine and H(4)R agonists clobenpropit and 4-methylhistamine downregulated the production of the Th2-linked chemokine CCL2 and the Th1 cytokine IL-12 on Mo-IDEC, whereas agonists for the other histamine receptors did not.	clobenpropit	43-55	negative elongation factor complex member C/D	Homo sapiens	148-151
17350613-0	2007	The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons.	clobenpropit	37-49	histamine receptor H3	Rattus norvegicus	4-25
17627982-7	2007	The excitatory actions of the agonists were specifically and selectively blocked by the H(1), H(2), H(3) or H(4) receptor antagonists pyrilamine, ranitidine, clobenpropit or J1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine (JNJ 7777120), respectively.	clobenpropit	158-170	H3 clustered histone 14	Homo sapiens	100-121
17507084-7	2007	H(4)R agonists (clobenpropit and 4-methylhistamine) induce a Ca(2+) mobilization in monocytes, which could be blocked with the selective H(4)R antagonist JNJ7,777,120.	clobenpropit	16-28	histamine receptor H4	Homo sapiens	0-5
17507084-7	2007	H(4)R agonists (clobenpropit and 4-methylhistamine) induce a Ca(2+) mobilization in monocytes, which could be blocked with the selective H(4)R antagonist JNJ7,777,120.	clobenpropit	16-28	histamine receptor H4	Homo sapiens	137-142
17350613-0	2007	The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons.	clobenpropit	37-49	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	136-152
17350613-2	2007	Clobenpropit reversed the neurotoxicity in a concentration-dependent manner, and showed peak protection at a concentration of 10(-7) M. This protection was antagonized by the histamine H3 receptor agonist (R)-alpha-methylhistamine, but not by the histamine H1 receptor antagonist pyrilamine or the histamine H2 receptor antagonist cimetidine.	clobenpropit	0-12	histamine receptor H3	Rattus norvegicus	175-196
17350613-2	2007	Clobenpropit reversed the neurotoxicity in a concentration-dependent manner, and showed peak protection at a concentration of 10(-7) M. This protection was antagonized by the histamine H3 receptor agonist (R)-alpha-methylhistamine, but not by the histamine H1 receptor antagonist pyrilamine or the histamine H2 receptor antagonist cimetidine.	clobenpropit	0-12	histamine receptor H 1	Rattus norvegicus	247-268
17350613-2	2007	Clobenpropit reversed the neurotoxicity in a concentration-dependent manner, and showed peak protection at a concentration of 10(-7) M. This protection was antagonized by the histamine H3 receptor agonist (R)-alpha-methylhistamine, but not by the histamine H1 receptor antagonist pyrilamine or the histamine H2 receptor antagonist cimetidine.	clobenpropit	0-12	histamine receptor H 2	Rattus norvegicus	298-319
17350613-6	2007	Furthermore, both the adenylyl cyclase inhibitor SQ-22536 and the protein kinase A (PKA) inhibitor H-89 reversed the protection and the GABA release by clobenpropit.	clobenpropit	152-164	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	66-82
17350613-6	2007	Furthermore, both the adenylyl cyclase inhibitor SQ-22536 and the protein kinase A (PKA) inhibitor H-89 reversed the protection and the GABA release by clobenpropit.	clobenpropit	152-164	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	84-87
17350613-8	2007	These results indicate that clobenpropit enhanced GABA release to protect against NMDA-induced excitotoxicity, which was induced through the cAMP/PKA pathway, and reduction of intracellular calcium level may also be involved.	clobenpropit	28-40	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	146-149
15082882-7	2004	Pretreatment with histamine H(3) receptor antagonist clobenpropit (4 micromol/kg i.a.)	clobenpropit	53-65	histamine receptor H3	Rattus norvegicus	18-41
14735131-4	2004	The aim of the present study was to evaluate the effects of two histamine H3 receptor antagonists, clobenpropit and thioperamide, on rewarding and neurochemical effects of methamphetamine utilizing three in vivo methodologies, drug self-administration, drug discrimination, and microdialysis in Sprague-Dawley rats.	clobenpropit	99-111	histamine receptor H3	Rattus norvegicus	64-85
17346280-4	2007	Dimaprit, clobenpropit and clozapine, which are H4R agonists, dose-dependently blocked both PPD-induced interferon-gamma and Cry j1-induced interleukin-5 production by both peripheral blood mononuclear cells (PBMCs) and antigen-specific T-cell lines.	clobenpropit	10-22	histamine receptor H4	Homo sapiens	48-51
17346280-4	2007	Dimaprit, clobenpropit and clozapine, which are H4R agonists, dose-dependently blocked both PPD-induced interferon-gamma and Cry j1-induced interleukin-5 production by both peripheral blood mononuclear cells (PBMCs) and antigen-specific T-cell lines.	clobenpropit	10-22	interferon gamma	Homo sapiens	104-120
17346280-4	2007	Dimaprit, clobenpropit and clozapine, which are H4R agonists, dose-dependently blocked both PPD-induced interferon-gamma and Cry j1-induced interleukin-5 production by both peripheral blood mononuclear cells (PBMCs) and antigen-specific T-cell lines.	clobenpropit	10-22	interleukin 5	Homo sapiens	140-153
15084444-5	2004	alpha-Fluoromethylhistidine (FMH, 25 microg per site), a selective histidine decarboxylase inhibitor prevented the ameliorating effect of clobenpropit on the working memory deficits induced by MK-801.	clobenpropit	138-150	histidine decarboxylase	Rattus norvegicus	67-90
15179677-5	2004	H(3)receptor agonist, immepip, and histidine decarboxylase, alpha-fluoromethylhistidine reversed the ameliorating effect of clobenpropit on seizure development in a dose-dependent manner.	clobenpropit	124-136	histidine decarboxylase	Rattus norvegicus	35-58
15082882-13	2004	Pretreatment with histamine H(3) receptor antagonist clobenpropit (0,4 micromol i.c.v.)	clobenpropit	53-65	histamine receptor H3	Rattus norvegicus	18-41
14729385-9	2004	Pretreatment with the selective histamine H3 receptor antagonist, clobenpropit (100 nM), blocked the sympathoinhibitory effect of (R)-alpha-methylhistamine on the neurogenic sympathetic vasoconstriction.	clobenpropit	66-78	histamine receptor H3	Homo sapiens	32-53
12372902-1	2002	Optical difference spectroscopy was used to identify and quantify human adrenal microsomal and mitochondrial cytochrome P450 enzyme interactions with the histamine H(3) receptor antagonists thioperamide, clobenpropit and ciproxifan.	clobenpropit	204-216	histamine receptor H3	Homo sapiens	154-177
12787830-7	2003	Clobenpropit (1 nM, a potent histamine H(3) receptor antagonist) "antagonised" the suppressive effect of SKF 91488 and histamine-evoked relaxation was restored.	clobenpropit	0-12	histamine receptor H3	Rattus norvegicus	29-52
11752226-8	2002	The cAMP-dependent protein kinase blockers Rp-cAMPs and PKI14-22 could impair the effects of thioperamide and clobenpropit, respectively.	clobenpropit	110-122	calmodulin 2, pseudogene 1	Rattus norvegicus	46-51
12235264-5	2002	Agonists selective for H(2) (dimaprit), H(3/4) (R-(-)-alpha-methylhistamine), and H(4) (clobenpropit) were capable of inducing the release of bioactive IL-16 because CD8(+) cell supernatants induced CD4(+) cell migration, which was abrogated by an anti-IL-16 antibody.	clobenpropit	88-100	interleukin 16	Homo sapiens	152-157
12235264-5	2002	Agonists selective for H(2) (dimaprit), H(3/4) (R-(-)-alpha-methylhistamine), and H(4) (clobenpropit) were capable of inducing the release of bioactive IL-16 because CD8(+) cell supernatants induced CD4(+) cell migration, which was abrogated by an anti-IL-16 antibody.	clobenpropit	88-100	CD8a molecule	Homo sapiens	166-169
12235264-5	2002	Agonists selective for H(2) (dimaprit), H(3/4) (R-(-)-alpha-methylhistamine), and H(4) (clobenpropit) were capable of inducing the release of bioactive IL-16 because CD8(+) cell supernatants induced CD4(+) cell migration, which was abrogated by an anti-IL-16 antibody.	clobenpropit	88-100	CD4 molecule	Homo sapiens	199-202
12235264-5	2002	Agonists selective for H(2) (dimaprit), H(3/4) (R-(-)-alpha-methylhistamine), and H(4) (clobenpropit) were capable of inducing the release of bioactive IL-16 because CD8(+) cell supernatants induced CD4(+) cell migration, which was abrogated by an anti-IL-16 antibody.	clobenpropit	88-100	interleukin 16	Homo sapiens	253-258
12359275-7	2002	Pretreatment with either of the selective histamine H(3) receptor antagonists, thioperamide and clobenpropit, blocked the sympathoinhibitory effect of (R)-alpha-methylhistamine in porcine turbinate mucosa.	clobenpropit	96-108	histamine receptor H3	Homo sapiens	42-65
12503632-5	2002	Ligand-binding studies using Pfi-013 expressed in HEK-293Galpha15 cells, demonstrates specific binding to histamine with a Kd of 3.28 +/- 0.76 nM and possesses a unique rank order of potency against known histaminergic compounds in a competitive ligand-binding assay (histamine > clobenpropit > iodophenpropit > thioperamide > R-alpha-methylhistamine > cimetidine > pyrilamine).	clobenpropit	283-295	histamine receptor H4	Homo sapiens	29-36
10973974-7	2000	In functional assays, not only an H3 receptor agonist, R-(alpha)-methylhistamine, but also a H3 receptor antagonist, clobenpropit, and a neuroleptic, clozapine, activated GPRv53-expressing cells.	clobenpropit	117-129	histamine receptor H4	Homo sapiens	171-177
11742589-1	2001	AIM: The effect of clobenpropit on regional cerebral blood flow (rCBF) was investigated in the rat hippocampus.	clobenpropit	19-31	CCAAT/enhancer binding protein zeta	Rattus norvegicus	65-69
11742589-4	2001	RESULTS: Intracerebroventricular (icv) injection of clobenpropit (20, 50 microg), a representative H3-antagonist, dose-dependently and significantly increased rCBF in the hippocampus.	clobenpropit	52-64	CCAAT/enhancer binding protein zeta	Rattus norvegicus	159-163
11742589-5	2001	The increase of rCBF induced by clobenpropit was enhanced by metoprine (1, 2 mg/kg), a selective histamine N-methyltransferase inhibitor; however, was antagonized by an H3-agonist, (R)-alpha-methylhistamine (5 microg), an H(1)-antagonist, mepyramine (5-10 mg/kg), and an H2-antagonist, zolantidine (10 mg/kg).	clobenpropit	32-44	CCAAT/enhancer binding protein zeta	Rattus norvegicus	16-20
9017245-0	1996	Brain penetration of the histamine H3 receptor antagonists thioperamide and clobenpropit in rat and mouse, determined with ex vivo [125I]iodophenpropit binding.	clobenpropit	76-88	histamine receptor H3	Rattus norvegicus	25-46
10556922-1	1999	1 We have investigated the binding of a novel histamine H3-receptor antagonist radioligand, [3H]- clobenpropit ([3H]-VUF9153), to guinea-pig cerebral cortex membranes.	clobenpropit	117-124	histamine H3 receptor	Cavia porcellus	46-67
10556922-10	1999	5 A series of histamine H3-receptor ligands expressed affinity values for sites labelled with [3H]-clobenpropit which were not significantly different from those estimated when [3H]-R-alpha-MH was used to label histamine H3-receptors in guinea-pig cerebral cortex membranes.	clobenpropit	99-111	histamine H3 receptor	Cavia porcellus	14-35
9874165-9	1998	In conclusion, intrahypothalamic perfusion of the histamine H3 receptor agonist, immepip and the histamine H3 receptor antagonist, clobenpropit, potently and oppositely modulated in vivo histamine release from the anterior hypothalamic area.	clobenpropit	131-143	histamine receptor H3	Rattus norvegicus	97-118
9826104-0	1998	Effect of clobenpropit, a centrally acting histamine H3-receptor antagonist, on electroshock- and pentylenetetrazol-induced seizures in mice.	clobenpropit	10-22	histamine receptor H3	Mus musculus	43-64
9017245-1	1996	We investigated the brain penetration of the histamine H3 receptor antagonists thioperamide and clobenpropit using ex vivo [125I]iodophenpropit binding.	clobenpropit	96-108	histamine receptor H3	Rattus norvegicus	45-66
7957622-0	1994	Clobenpropit (VUF-9153), a new histamine H3 receptor antagonist, inhibits electrically induced convulsions in mice.	clobenpropit	0-12	histamine receptor H3	Mus musculus	31-52
8982515-9	1996	The inhibitory effect of 100 microM histamine was completely prevented by the highly selective histamine H3 receptor antagonist, clobenpropit but was resistant to antagonism by triprolidine and cimetidine, antagonists at histamine H1 and H2 but not H3 receptors.	clobenpropit	129-141	histamine receptor H3	Rattus norvegicus	95-116
7957622-0	1994	Clobenpropit (VUF-9153), a new histamine H3 receptor antagonist, inhibits electrically induced convulsions in mice.	clobenpropit	14-22	histamine receptor H3	Mus musculus	31-52
7957622-4	1994	These findings suggest that the effect of clobenpropit on electrically induced convulsions is due to an increase in endogenous histamine release in the brain, which is consistent with biochemical results that clobenpropit increased brain histidine decarboxylase activity dose dependently.	clobenpropit	42-54	histidine decarboxylase	Mus musculus	238-261
7957622-4	1994	These findings suggest that the effect of clobenpropit on electrically induced convulsions is due to an increase in endogenous histamine release in the brain, which is consistent with biochemical results that clobenpropit increased brain histidine decarboxylase activity dose dependently.	clobenpropit	209-221	histidine decarboxylase	Mus musculus	238-261
7957622-5	1994	The anticonvulsive effect of clobenpropit was antagonized by mepyramine, a histamine H1 receptor antagonist, but not by zolantidine, a histamine H2 receptor antagonist, indicating that histamine released by the anticonvulsant effect of clobenpropit interacts with histamine H1 receptors of postsynaptic neurons.	clobenpropit	29-41	histamine receptor H1	Mus musculus	75-96
30536350-0	2018	Histamine H3 receptor antagonist Clobenpropit protects propofol-induced apoptosis of hippocampal neurons through PI3K/AKT pathway.	clobenpropit	33-45	histamine receptor H3	Rattus norvegicus	0-21
34942919-1	2021	Clobenpropit (CLO), an antagonist on histamine H3 receptors (HH3R), has been shown to protect NMDA-induced neuronal necrosis in cortical neuronal cell culture from rats.	clobenpropit	0-12	histamine receptor H3	Rattus norvegicus	37-59
34942919-1	2021	Clobenpropit (CLO), an antagonist on histamine H3 receptors (HH3R), has been shown to protect NMDA-induced neuronal necrosis in cortical neuronal cell culture from rats.	clobenpropit	0-12	histamine receptor H3	Rattus norvegicus	61-65
34942919-1	2021	Clobenpropit (CLO), an antagonist on histamine H3 receptors (HH3R), has been shown to protect NMDA-induced neuronal necrosis in cortical neuronal cell culture from rats.	clobenpropit	14-17	histamine receptor H3	Rattus norvegicus	37-59
34942919-1	2021	Clobenpropit (CLO), an antagonist on histamine H3 receptors (HH3R), has been shown to protect NMDA-induced neuronal necrosis in cortical neuronal cell culture from rats.	clobenpropit	14-17	histamine receptor H3	Rattus norvegicus	61-65
30536350-10	2018	CONCLUSIONS: Clobenpropit protects propofol-induced neuronal apoptosis through activating PI3K/AKT pathway.	clobenpropit	13-25	AKT serine/threonine kinase 1	Rattus norvegicus	95-98
8119312-0	1993	Pharmacological activity of VUF 9153, an isothiourea histamine H3 receptor antagonist.	clobenpropit	28-36	histamine receptor H3	Rattus norvegicus	53-74
8119312-1	1993	The pharmacological activity of the histamine H3 receptor antagonist VUF 9153 (S-[3-(4(5)-imidazolyl)]propyl-N-(4-chlorobenzyl)isothiourea) has been investigated in vitro and in vivo.	clobenpropit	69-77	histamine receptor H3	Rattus norvegicus	36-57
8119312-1	1993	The pharmacological activity of the histamine H3 receptor antagonist VUF 9153 (S-[3-(4(5)-imidazolyl)]propyl-N-(4-chlorobenzyl)isothiourea) has been investigated in vitro and in vivo.	clobenpropit	79-138	histamine receptor H3	Rattus norvegicus	36-57
30536350-0	2018	Histamine H3 receptor antagonist Clobenpropit protects propofol-induced apoptosis of hippocampal neurons through PI3K/AKT pathway.	clobenpropit	33-45	AKT serine/threonine kinase 1	Rattus norvegicus	118-121
30536350-1	2018	OBJECTIVE: The aim of the study was to explore whether histamine H3 receptor antagonist Clobenpropit could protect propofol-induced neurotoxicity in hippocampal neurons.	clobenpropit	88-100	histamine receptor H3	Rattus norvegicus	55-76
30536350-8	2018	Protein expressions of cleaved-caspase-3 and Bax/Bcl2 were remarkably downregulated in neurons treated with Clobenpropit.	clobenpropit	108-120	BCL2 associated X, apoptosis regulator	Rattus norvegicus	45-48
30536350-8	2018	Protein expressions of cleaved-caspase-3 and Bax/Bcl2 were remarkably downregulated in neurons treated with Clobenpropit.	clobenpropit	108-120	BCL2, apoptosis regulator	Rattus norvegicus	49-53
30536350-9	2018	LY294002 induction remarkably reverses the protective role of Clobenpropit in neuronal apoptosis, manifesting as downregulated PI3K and p-AKT after LY294002 treatment.	clobenpropit	62-74	AKT serine/threonine kinase 1	Rattus norvegicus	138-141
29414147-0	2018	Clobenpropit, a histamine H3 receptor antagonist/inverse agonist, inhibits [3H]-dopamine uptake by human neuroblastoma SH-SY5Y cells and rat brain synaptosomes.	clobenpropit	0-12	histamine receptor H3	Homo sapiens	16-37
30071054-11	2018	Furthermore, it was found that the premedication with prazosin, yohimbine, 6-hydroxydopamine and the vasopressin V1a receptor antagonist blocked the effects of clobenpropit.	clobenpropit	160-172	arginine vasopressin receptor 1A	Rattus norvegicus	101-125
29414147-7	2018	Clobenpropit inhibited [3H]-dopamine uptake (maximum inhibition 82.7+-2.8%, IC50 490nM), and the effect was reproduced by the H3R antagonist/inverse agonist iodophenpropit, but not by the agonists R-alpha-methylhistamine and immepip or the antagonists/inverse agonists ciproxifan and A-331440.	clobenpropit	0-12	histamine receptor H3	Homo sapiens	126-129
29414147-1	2018	BACKGROUND: Clobenpropit, a potent antagonist/inverse agonist at the histamine H3 receptor (H3R), reduced the cytotoxic action of 6-hydroxydopamine (6-OHDA) in neuroblastoma SH-SY5Y cells transfected with the human H3R.	clobenpropit	12-24	histamine receptor H3	Homo sapiens	69-90
29414147-9	2018	Modeling of the human NET and DAT obtained by homology from the crystal of Drosophila melanogaster DAT showed that clobenpropit can bind to a site also recognized in both transporters by nisoxetine, a potent NET inhibitor.	clobenpropit	115-127	solute carrier family 6 member 3	Homo sapiens	30-33
29414147-1	2018	BACKGROUND: Clobenpropit, a potent antagonist/inverse agonist at the histamine H3 receptor (H3R), reduced the cytotoxic action of 6-hydroxydopamine (6-OHDA) in neuroblastoma SH-SY5Y cells transfected with the human H3R.	clobenpropit	12-24	histamine receptor H3	Homo sapiens	92-95
29414147-9	2018	Modeling of the human NET and DAT obtained by homology from the crystal of Drosophila melanogaster DAT showed that clobenpropit can bind to a site also recognized in both transporters by nisoxetine, a potent NET inhibitor.	clobenpropit	115-127	Dopamine transporter	Drosophila melanogaster	99-102
29414147-1	2018	BACKGROUND: Clobenpropit, a potent antagonist/inverse agonist at the histamine H3 receptor (H3R), reduced the cytotoxic action of 6-hydroxydopamine (6-OHDA) in neuroblastoma SH-SY5Y cells transfected with the human H3R.	clobenpropit	12-24	histamine receptor H3	Homo sapiens	215-218
29414147-4	2018	Clobenpropit binding to the human norepinephrine (NET) and dopamine (DAT) transporters was analyzed by molecular modeling.	clobenpropit	0-12	solute carrier family 6 member 3	Homo sapiens	69-72
26907350-6	2016	At week 18, feeding with the diets containing cimetidine (Hrh2 antagonist) and clobenpropit (Hrh3 antagonist/inverse agonist) significantly lowered the multiplicity of colonic adenocarcinoma.	clobenpropit	79-91	histamine receptor H3	Mus musculus	93-97
26907350-9	2016	Because clobenpropit is also known to be a Hrh4 receptor agonist, Hrh2, Hrh3 and Hrh4 may be involved in inflammation-related colorectal carcinogenesis.	clobenpropit	8-20	histamine receptor H4	Mus musculus	43-47
26907350-9	2016	Because clobenpropit is also known to be a Hrh4 receptor agonist, Hrh2, Hrh3 and Hrh4 may be involved in inflammation-related colorectal carcinogenesis.	clobenpropit	8-20	histamine receptor H2	Mus musculus	66-70
26907350-9	2016	Because clobenpropit is also known to be a Hrh4 receptor agonist, Hrh2, Hrh3 and Hrh4 may be involved in inflammation-related colorectal carcinogenesis.	clobenpropit	8-20	histamine receptor H3	Mus musculus	72-76
26907350-9	2016	Because clobenpropit is also known to be a Hrh4 receptor agonist, Hrh2, Hrh3 and Hrh4 may be involved in inflammation-related colorectal carcinogenesis.	clobenpropit	8-20	histamine receptor H4	Mus musculus	81-85
25024609-9	2014	Clobenpropit up-regulated E-cadherin, but down-regulated vimentin and matrix metalloproteinase 9 in real-time polymerase chain reaction.	clobenpropit	0-12	cadherin 1	Homo sapiens	26-36
25762718-8	2015	RESULTS: Clobenpropit, administered systemically or directly into the hippocampus, decreased immobility during the forced swim test; systemic injections reversed memory deficits and increased hippocampal GluN2A protein levels.	clobenpropit	9-21	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	204-210
25762718-13	2015	Clobenpropit reverses memory deficits and increases hippocampal GluN2A expression without modifying anxiety-related phenotypes or EPSCs in CA1 pyramidal neurons.	clobenpropit	0-12	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	64-70
25024609-9	2014	Clobenpropit up-regulated E-cadherin, but down-regulated vimentin and matrix metalloproteinase 9 in real-time polymerase chain reaction.	clobenpropit	0-12	vimentin	Homo sapiens	57-65
25024609-9	2014	Clobenpropit up-regulated E-cadherin, but down-regulated vimentin and matrix metalloproteinase 9 in real-time polymerase chain reaction.	clobenpropit	0-12	matrix metallopeptidase 9	Homo sapiens	70-96
25024609-10	2014	Also, clobenpropit inhibited tumor growth (gemcitabine 294 +- 46 mg vs combination 154 +- 54 mg, P = 0.02) and enhanced apoptosis in combination with gemcitabine (control 2.5%, gemcitabine 25.8%, clobenpropit 9.7% and combination 40.9%, P = 0.001) by up-regulation of E-cadherin and down-regulation of Zeb1 in Panc-1 xenograft mouse.	clobenpropit	6-18	cadherin 1	Mus musculus	268-278
25024609-10	2014	Also, clobenpropit inhibited tumor growth (gemcitabine 294 +- 46 mg vs combination 154 +- 54 mg, P = 0.02) and enhanced apoptosis in combination with gemcitabine (control 2.5%, gemcitabine 25.8%, clobenpropit 9.7% and combination 40.9%, P = 0.001) by up-regulation of E-cadherin and down-regulation of Zeb1 in Panc-1 xenograft mouse.	clobenpropit	6-18	zinc finger E-box binding homeobox 1	Mus musculus	302-306
25024609-10	2014	Also, clobenpropit inhibited tumor growth (gemcitabine 294 +- 46 mg vs combination 154 +- 54 mg, P = 0.02) and enhanced apoptosis in combination with gemcitabine (control 2.5%, gemcitabine 25.8%, clobenpropit 9.7% and combination 40.9%, P = 0.001) by up-regulation of E-cadherin and down-regulation of Zeb1 in Panc-1 xenograft mouse.	clobenpropit	6-18	pancreas protein 1	Mus musculus	310-316
20197375-0	2010	Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.	clobenpropit	100-112	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	153-182
23220277-4	2013	Clobenpropit is then docked into the binding pocket of H4R and two different binding modes can be identified.	clobenpropit	0-12	histamine receptor H4	Homo sapiens	55-58
21272571-6	2011	Clobenpropit (histamine H(3) receptor antagonist, 1muM) canceled the alpha-methylhistamine-induced decrease in the periarterial nerve stimulation-induced vasoconstriction and noradrenaline release and periarterial nerve stimulation-induced vasodilation.	clobenpropit	0-12	histamine receptor H3	Rattus norvegicus	14-37
22003888-5	2011	We have designed and synthesized a series of clobenpropit (N-(4-chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothiourea) derivatives to investigate H(4)R-ligand interactions and ligand binding orientations.	clobenpropit	45-57	histamine receptor H4	Homo sapiens	147-152
22003888-6	2011	Interestingly, our studies indicate that clobenpropit (2) itself can bind to H(4)R in two distinct binding modes, while the addition of a cyclohexyl group to the clobenpropit isothiourea moiety allows VUF5228 (5) to adopt only one specific binding mode in the H(4)R binding pocket.	clobenpropit	41-53	histamine receptor H4	Homo sapiens	77-82
22003888-6	2011	Interestingly, our studies indicate that clobenpropit (2) itself can bind to H(4)R in two distinct binding modes, while the addition of a cyclohexyl group to the clobenpropit isothiourea moiety allows VUF5228 (5) to adopt only one specific binding mode in the H(4)R binding pocket.	clobenpropit	41-53	histamine receptor H4	Homo sapiens	260-265
20511290-1	2011	Clobenpropit, an H( 3) receptor antagonist, has been reported to modulate both the release of neurotransmitters and also the activity of histidine decarboxylase (HDC).	clobenpropit	0-12	histidine decarboxylase	Mus musculus	137-160
20511290-1	2011	Clobenpropit, an H( 3) receptor antagonist, has been reported to modulate both the release of neurotransmitters and also the activity of histidine decarboxylase (HDC).	clobenpropit	0-12	histidine decarboxylase	Mus musculus	162-165
20197375-6	2010	This strategy identified several novel modulators of NMDA receptor function, including the histamine H3 receptor antagonists clobenpropit and iodophenpropit, as well as the vanilloid receptor transient receptor potential cation channel, subfamily V, member 1 (TRPV1) antagonist capsazepine.	clobenpropit	125-137	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	53-66
20045936-7	2010	This vasodilation was abolished by endothelium removal and attenuated by histamine H(3) receptor antagonists, thioperamide and clobenpropit, but not by chlorpheniramine (histamine H(1) receptor antagonist) and cimetidine (histamine H(2) receptor antagonist).	clobenpropit	127-139	histamine receptor H 2	Rattus norvegicus	222-245
19414267-1	2009	Previous studies have demonstrated that clobenpropit (N-(4-chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothiourea) binds to both the human histamine H(3) receptor (H(3)R) and H(4) receptor (H(4)R).	clobenpropit	40-52	histamine receptor H3	Homo sapiens	139-162
19414267-1	2009	Previous studies have demonstrated that clobenpropit (N-(4-chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothiourea) binds to both the human histamine H(3) receptor (H(3)R) and H(4) receptor (H(4)R).	clobenpropit	40-52	histamine receptor H4	Homo sapiens	175-196
19414267-2	2009	In this paper, we describe the synthesis and pharmacological characterization of a series of clobenpropit analogs, which vary in the functional group adjacent to the isothiourea moiety in order to study structural requirements for H(3)R and H(4)R ligands.	clobenpropit	93-105	histamine receptor H3	Homo sapiens	231-246
19281909-8	2009	H(4)R agonists (clobenpropit and 4-methylhistamine) induced AP-1 in T(H)2 cells but not in T(H)1 cells.	clobenpropit	16-28	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	60-64
18782117-8	2008	Histamine as well as the H4R agonist clobenpropit induced an enhanced chemotaxis in the skin DC migration assay.	clobenpropit	37-49	histamine receptor H4	Mus musculus	25-28