PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 31421166-9 2019 Further investigation of grp94 inhibitors may lead to a new class of broad-spectrum anti-flaviviral medications. flaviviral 89-99 heat shock protein 90 beta family member 1 Homo sapiens 25-30 34741027-1 2021 To understand how RNA dynamics is regulated and connected to its function, we investigate the folding, conformational dynamics and robustness of Xrn1 resistance of a set of flaviviral xrRNAs using SAXS, smFRET and in vitro enzymatic assays. flaviviral 173-183 5'-3' exoribonuclease 1 Homo sapiens 145-149 35203378-6 2022 This work highlights the NS5-NS3 binding interface as a viable target for the development of anti-flaviviral therapeutics. flaviviral 98-108 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 25-28 35203378-6 2022 This work highlights the NS5-NS3 binding interface as a viable target for the development of anti-flaviviral therapeutics. flaviviral 98-108 KRAS proto-oncogene, GTPase Homo sapiens 29-32 32950301-3 2020 The flaviviral CP is the smallest structural protein and forms a homodimer by antiparallel alpha-helixes. flaviviral 4-14 ceruloplasmin Homo sapiens 15-17 22615830-3 2012 Being indispensable for flaviviral replication, the NS2B-NS3 protease is a promising target for design of anti-flaviviral inhibitors. flaviviral 24-34 KRAS proto-oncogene, GTPase Homo sapiens 57-60 22615830-3 2012 Being indispensable for flaviviral replication, the NS2B-NS3 protease is a promising target for design of anti-flaviviral inhibitors. flaviviral 111-121 KRAS proto-oncogene, GTPase Homo sapiens 57-60 21143108-13 2011 Peptide inhibitors against the highly conserved NS2B and NS3 proteases are attractive as pan-flaviviral drug candidates. flaviviral 93-103 KRAS proto-oncogene, GTPase Homo sapiens 57-60 22102908-0 2011 Ago-2-mediated slicer activity is essential for anti-flaviviral efficacy of RNAi. flaviviral 53-63 argonaute RISC catalytic component 2 Homo sapiens 0-5