PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9837917-2	1998	We now report that repair by mammalian alkylpurine-DNA-N-glycosylases (APNG) of 15-mer oligonucleotides with a central 1,N6-ethenoadenine (epsilonA), flanked by 5" and 3" tandem bases, is also highly sequence dependent.	epsilona	139-147	N-methylpurine DNA glycosylase	Homo sapiens	39-69
10329732-5	1999	In mammalian cells hypoxanthine (HX) and 1,N6-ethenoadenine (epsilonA) are both substrates for the monofunctional 3-methyladenine DNA glycosylase, the ANPG protein, whereas 7,8-dihydro-8-oxoguanine (8-oxoG) is removed by the bifunctional DNA glycosylase/beta-lyase 8-oxoG-DNA gly- cosylase (OGG1).	epsilona	61-69	N-methylpurine DNA glycosylase	Homo sapiens	151-155
10329732-5	1999	In mammalian cells hypoxanthine (HX) and 1,N6-ethenoadenine (epsilonA) are both substrates for the monofunctional 3-methyladenine DNA glycosylase, the ANPG protein, whereas 7,8-dihydro-8-oxoguanine (8-oxoG) is removed by the bifunctional DNA glycosylase/beta-lyase 8-oxoG-DNA gly- cosylase (OGG1).	epsilona	61-69	8-oxoguanine DNA glycosylase	Homo sapiens	291-295
9837917-2	1998	We now report that repair by mammalian alkylpurine-DNA-N-glycosylases (APNG) of 15-mer oligonucleotides with a central 1,N6-ethenoadenine (epsilonA), flanked by 5" and 3" tandem bases, is also highly sequence dependent.	epsilona	139-147	N-methylpurine DNA glycosylase	Homo sapiens	71-75
31310499-1	2019	Alkyladenine DNA glycosylase (AAG) is the only known human glycosylase capable of excising alkylated purines from DNA, including the highly mutagenic 1,N6-ethenoadenine (epsilonA) lesion.	epsilona	170-178	N-methylpurine DNA glycosylase	Homo sapiens	0-28
34500720-3	2021	Here, we consider the repair aspect of 1,N6-ethenoadenine (epsilonA) by the 2-oxoglutarate/Fe(II)-dependent AlkB family enzymes.	epsilona	59-67	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	108-112
32872297-1	2020	Human apurinic/apyrimidinic (AP) endonuclease APE1 hydrolyzes phosphodiester bonds on the 5" side of an AP-site, and some damaged nucleotides such as 1,N6-ethenoadenosine (epsilonA), alpha-adenosine (alphaA), and 5,6-dihydrouridine (DHU).	epsilona	172-180	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	46-50
31310499-1	2019	Alkyladenine DNA glycosylase (AAG) is the only known human glycosylase capable of excising alkylated purines from DNA, including the highly mutagenic 1,N6-ethenoadenine (epsilonA) lesion.	epsilona	170-178	N-methylpurine DNA glycosylase	Homo sapiens	30-33
21349833-2	2011	Although the human alkyladenine DNA glycosylase (AAG) can specifically bind DNA containing either 1,N(6)-ethenoadenine (epsilonA) lesions or 3,N(4)-ethenocytosine (epsilonC) lesions, it can only excise epsilonA lesions.	epsilona	120-128	N-methylpurine DNA glycosylase	Homo sapiens	19-47
27025273-3	2017	To understand better, how the step of nucleotide eversion influences the overall catalytic process, we performed a pre-steady-state kinetic analysis of AAG interaction with specific DNA-substrates, 13-base pair duplexes containing in the 7th position 1-N6-ethenoadenine (epsilonA), hypoxanthine (Hx), and the stable product analogue tetrahydrofuran (F).	epsilona	271-279	N-methylpurine DNA glycosylase	Homo sapiens	152-155
25355292-2	2014	Here, we present the development of reproducible and specific enzymatic assays for methylpurine DNA glycosylase (MPG) repairing the oxidative lesions 1,N6-ethenoadenine (epsilonA) and hypoxanthine (Hx) in peripheral blood mononuclear cells protein extracts.	epsilona	170-178	N-methylpurine DNA glycosylase	Homo sapiens	113-116
25355292-2	2014	Here, we present the development of reproducible and specific enzymatic assays for methylpurine DNA glycosylase (MPG) repairing the oxidative lesions 1,N6-ethenoadenine (epsilonA) and hypoxanthine (Hx) in peripheral blood mononuclear cells protein extracts.	epsilona	170-178	N-methylpurine DNA glycosylase	Homo sapiens	83-111
25203306-2	2014	We use in-protein QM/MM calculations to study the repair of etheno-bridged adenine (epsilonA) by the iron(IV)-oxo species of AlkB enzymes.	epsilona	84-92	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	125-129
21349833-2	2011	Although the human alkyladenine DNA glycosylase (AAG) can specifically bind DNA containing either 1,N(6)-ethenoadenine (epsilonA) lesions or 3,N(4)-ethenocytosine (epsilonC) lesions, it can only excise epsilonA lesions.	epsilona	120-128	N-methylpurine DNA glycosylase	Homo sapiens	49-52
21068844-5	2010	Using a chemical cross-linking strategy, complexes of AlkB-double stranded DNA (dsDNA) containing 1,N(6)-etheno adenine (epsilonA), N(3)-methyl thymine (3-meT) and N(3)-methyl cytosine (3-meC) are stabilized and crystallized, respectively.	epsilona	121-129	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	54-58
20873830-2	2010	Surprisingly, human alkyladenine DNA glycosylase (AAG) can make damaged DNA by catalyzing formation of an N-glycosyl bond between 1,N(6)-ethenoadenine (epsilonA) and abasic DNA.	epsilona	152-160	N-methylpurine DNA glycosylase	Homo sapiens	20-48
20873830-2	2010	Surprisingly, human alkyladenine DNA glycosylase (AAG) can make damaged DNA by catalyzing formation of an N-glycosyl bond between 1,N(6)-ethenoadenine (epsilonA) and abasic DNA.	epsilona	152-160	N-methylpurine DNA glycosylase	Homo sapiens	50-53
19219989-1	2009	The human 3-methyladenine DNA glycosylase (AAG) recognizes and excises a broad range of purines damaged by alkylation and oxidative damage, including 3-methyladenine, 7-methylguanine, hypoxanthine (Hx), and 1,N(6)-ethenoadenine (epsilonA).	epsilona	229-237	N-methylpurine DNA glycosylase	Homo sapiens	10-41
19219989-1	2009	The human 3-methyladenine DNA glycosylase (AAG) recognizes and excises a broad range of purines damaged by alkylation and oxidative damage, including 3-methyladenine, 7-methylguanine, hypoxanthine (Hx), and 1,N(6)-ethenoadenine (epsilonA).	epsilona	229-237	N-methylpurine DNA glycosylase	Homo sapiens	43-46
18593189-1	2008	1,N(6)-ethenoadenine (epsilonA) is a highly mutagenic lesion that is excised from human DNA by the enzyme alkyladenine DNA glycosylase (AAG).	epsilona	22-30	N-methylpurine DNA glycosylase	Homo sapiens	136-139
16231911-1	2005	The exocyclic DNA base adduct 1,N6-ethenoadenine (epsilonA) is directly repaired by the AlkB proteins in vitro.	epsilona	50-58	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	88-92
10891085-8	2000	For comparison, the apparent dissociation constant for an oligonucleotide containing a single 1,N(6)-ethenoadenine (epsilonA), which is repaired efficiently by AAG, was 26 nM.	epsilona	116-124	N-methylpurine DNA glycosylase	Homo sapiens	160-163