PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12509290-7	2002	To explore this further, we studied the removal of 7-methylguanine (7MeG) and 3-methyladenine (3MeA) from the dihydrofolate reductase (dhfr) gene of murine cell lines that vary in their repair phenotypes.	3-methyladenine	78-93	dihydrofolate reductase	Mus musculus	135-139
12147295-6	2002	Both compounds also inhibited the release of cytochrome c (by 82%, 20 mM 3-MA and 95%, 0.9 mM olomoucine), similar to the inhibition obtained with cyclosporine A, and 5mM ADP or ATP.	3-methyladenine	73-77	cytochrome c, somatic	Homo sapiens	45-57
12024048-4	2002	MMS-induced DNA lesions include base damages such as 3-methyl adenine and 7-methyl guanine, and these lesions are removed in yeast by the alternate competing pathways of base excision repair (BER), which is initiated by the action of MAG1-encoded N-methyl purine DNA glycosylase, and NER.	3-methyladenine	53-69	DNA-3-methyladenine glycosylase II	Saccharomyces cerevisiae S288C	234-238
12175670-6	2002	The presence of 3-MA during in vitro maturation of reticulocytes induced a decrease in exosome secretion, as measured by the amount of transferrin receptor (TfR) released in the extracellular medium.	3-methyladenine	16-20	transferrin receptor	Rattus norvegicus	135-155
12175670-6	2002	The presence of 3-MA during in vitro maturation of reticulocytes induced a decrease in exosome secretion, as measured by the amount of transferrin receptor (TfR) released in the extracellular medium.	3-methyladenine	16-20	transferrin receptor	Rattus norvegicus	157-160
11241348-4	2001	In addition, starvation-induced degradation of aldolase B was inhibited by chloroquine, an inhibitor of lysosomal proteinases and by 3-methyladenine, an inhibitor of autophagy.	3-methyladenine	133-148	aldolase, fructose-bisphosphate B	Rattus norvegicus	47-57
11173534-12	2001	Amino acids and 3-methyladenine, both of which specifically suppress macroautophagy, inhibited the accumulation of p32 as well as of p44.	3-methyladenine	16-31	mitogen activated protein kinase 3	Rattus norvegicus	133-136
10980409-1	2000	The methylpurine-DNA glycosylase (MPG) gene coding for human 3-methyladenine (3-meAde)-DNA glycosylase functions in the first step of base excision repair (BER) to remove numerous damaged bases including 3-meGua, ethenoadenine, and hypoxanthine (Hx) in addition to 3-meAde.	3-methyladenine	61-76	N-methylpurine DNA glycosylase	Homo sapiens	4-32
10980409-1	2000	The methylpurine-DNA glycosylase (MPG) gene coding for human 3-methyladenine (3-meAde)-DNA glycosylase functions in the first step of base excision repair (BER) to remove numerous damaged bases including 3-meGua, ethenoadenine, and hypoxanthine (Hx) in addition to 3-meAde.	3-methyladenine	61-76	N-methylpurine DNA glycosylase	Homo sapiens	34-37
10980409-1	2000	The methylpurine-DNA glycosylase (MPG) gene coding for human 3-methyladenine (3-meAde)-DNA glycosylase functions in the first step of base excision repair (BER) to remove numerous damaged bases including 3-meGua, ethenoadenine, and hypoxanthine (Hx) in addition to 3-meAde.	3-methyladenine	78-85	N-methylpurine DNA glycosylase	Homo sapiens	4-32
10980409-1	2000	The methylpurine-DNA glycosylase (MPG) gene coding for human 3-methyladenine (3-meAde)-DNA glycosylase functions in the first step of base excision repair (BER) to remove numerous damaged bases including 3-meGua, ethenoadenine, and hypoxanthine (Hx) in addition to 3-meAde.	3-methyladenine	78-85	N-methylpurine DNA glycosylase	Homo sapiens	34-37
10980409-1	2000	The methylpurine-DNA glycosylase (MPG) gene coding for human 3-methyladenine (3-meAde)-DNA glycosylase functions in the first step of base excision repair (BER) to remove numerous damaged bases including 3-meGua, ethenoadenine, and hypoxanthine (Hx) in addition to 3-meAde.	3-methyladenine	265-272	N-methylpurine DNA glycosylase	Homo sapiens	4-32
10980409-1	2000	The methylpurine-DNA glycosylase (MPG) gene coding for human 3-methyladenine (3-meAde)-DNA glycosylase functions in the first step of base excision repair (BER) to remove numerous damaged bases including 3-meGua, ethenoadenine, and hypoxanthine (Hx) in addition to 3-meAde.	3-methyladenine	265-272	N-methylpurine DNA glycosylase	Homo sapiens	34-37
10684927-3	2000	They are excised, although with different efficiencies, by an activity of the 3-methyl-adenine (3-meAde)-DNA glycosylases from Escherichia coli (AlkA protein), human cells (ANPG protein), rat cells (APDG protein) and yeast (MAG protein).	3-methyladenine	78-94	N-methylpurine DNA glycosylase	Homo sapiens	173-177
10684927-3	2000	They are excised, although with different efficiencies, by an activity of the 3-methyl-adenine (3-meAde)-DNA glycosylases from Escherichia coli (AlkA protein), human cells (ANPG protein), rat cells (APDG protein) and yeast (MAG protein).	3-methyladenine	96-103	N-methylpurine DNA glycosylase	Homo sapiens	173-177
10663625-6	2000	DNA methyl adducts were quantified by measuring urinary 3-methyladenine (3-MeA) excretion using immunoaffinity ELISA.	3-methyladenine	56-71	male-enhanced antigen 1	Homo sapiens	75-78
10576889-4	1999	The anti-autophagic drug 3-methyladenine also delayed apoptosis, its neuroprotection correlating with inhibition of cytochrome c release from mitochondria and prevention of caspase activation.	3-methyladenine	25-40	cytochrome c, somatic	Homo sapiens	116-128
9873051-4	1999	The addition of 3-methyladenine (3MA) to H4IIE cells deprived of amino acids inhibited the increment in protein degradation caused by amino acid withdrawal nearly completely at 10 mM and also strongly inhibited the ability of insulin to stimulate p70 and 4E-BP1 at 10 mM.	3-methyladenine	16-31	insulin	Homo sapiens	226-233
9873051-4	1999	The addition of 3-methyladenine (3MA) to H4IIE cells deprived of amino acids inhibited the increment in protein degradation caused by amino acid withdrawal nearly completely at 10 mM and also strongly inhibited the ability of insulin to stimulate p70 and 4E-BP1 at 10 mM.	3-methyladenine	16-31	annexin A6	Homo sapiens	247-250
9873051-4	1999	The addition of 3-methyladenine (3MA) to H4IIE cells deprived of amino acids inhibited the increment in protein degradation caused by amino acid withdrawal nearly completely at 10 mM and also strongly inhibited the ability of insulin to stimulate p70 and 4E-BP1 at 10 mM.	3-methyladenine	16-31	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	255-261
9886486-18	1999	This degradation was suppressed by chloroquine and 3-methyladenine, suggesting that aldolase B was being degraded within autolysosomes.	3-methyladenine	51-66	aldolase, fructose-bisphosphate B	Rattus norvegicus	84-94
9479003-4	1998	Moreover, we established that 3-methyladenine, a relatively minor DNA lesion produced by most methylating agents (which form mainly 7-methylguanine), can specifically induce sister chromatid exchange, chromatid and chromosome gaps and breaks, S phase arrest, the accumulation of p53, and apoptosis.	3-methyladenine	30-45	tumor protein p53	Homo sapiens	279-282
9403008-8	1997	Ultracondensed (UC phase) mitochondria were observed in cells undergoing both TNF alpha-induced and spontaneous apoptosis and were seen when TNF alpha-induced apoptosis was inhibited by 3-methyladenine (3MA).	3-methyladenine	186-201	tumor necrosis factor	Homo sapiens	141-150
9403008-8	1997	Ultracondensed (UC phase) mitochondria were observed in cells undergoing both TNF alpha-induced and spontaneous apoptosis and were seen when TNF alpha-induced apoptosis was inhibited by 3-methyladenine (3MA).	3-methyladenine	203-206	tumor necrosis factor	Homo sapiens	141-150
9249006-5	1997	The lysosomotropic agent ammonium chloride and the inhibitor of autophagocytosis 3-methyladenine slowed down CYP2E1 degradation by about 30%, while leupeptin had no effect.	3-methyladenine	81-96	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	109-115
8943309-6	1996	Treatment of fibroblasts with either bafilomycin A1 or 3-methyladenine indicates that proteolytic cleavage of SAP precursor begins as early as in the late endosomes.	3-methyladenine	55-70	SH2 domain containing 1A	Homo sapiens	110-113
8895486-3	1996	While both proteins prefer 3-methyladenine over other N-alkylpurines in DNA, the mouse MPG removes 7-methylguanine and 3-methylguanine at an approximately 2- to 3-fold higher rate than the human protein when adjusted for equal activity for the release of 3-methyladenine from DNA.	3-methyladenine	27-42	N-methylpurine-DNA glycosylase	Mus musculus	87-90
8895486-3	1996	While both proteins prefer 3-methyladenine over other N-alkylpurines in DNA, the mouse MPG removes 7-methylguanine and 3-methylguanine at an approximately 2- to 3-fold higher rate than the human protein when adjusted for equal activity for the release of 3-methyladenine from DNA.	3-methyladenine	255-270	N-methylpurine-DNA glycosylase	Mus musculus	87-90
7788844-2	1995	It was previously shown that increased removal of 3-alkylated adenine, effected by 3-methyladenine DNA glycosylase I (Tag), reduces the frequencies of hprt mutations induced by alkylating agents which produce mostly N-alkylation (MMS and EMS) to half the normal rate.	3-methyladenine	83-98	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	151-155
7528899-1	1995	The main N-alkylation products induced in DNA by methylating mutagens (7-methylguanine, 3-methyladenine, 3-methylguanine) are removed by excision repair involving, in the first step of the repair pathway, N-methylpurine-DNA glycosylase (MPG).	3-methyladenine	88-103	DNA-3-methyladenine glycosylase	Cricetulus griseus	205-235
7528899-1	1995	The main N-alkylation products induced in DNA by methylating mutagens (7-methylguanine, 3-methyladenine, 3-methylguanine) are removed by excision repair involving, in the first step of the repair pathway, N-methylpurine-DNA glycosylase (MPG).	3-methyladenine	88-103	DNA-3-methyladenine glycosylase	Cricetulus griseus	237-240
7889984-6	1994	In addition, immunofluorescence labeling showed that 3-methyladenine treatment caused accumulation of cathepsin L in the perinuclear area.	3-methyladenine	53-68	cathepsin L	Rattus norvegicus	102-113
7889984-9	1994	In conclusion, both endocytic pulse-chase experiments and immunoprecipitation of metabolically labeled cathepsin L indicate that 3-methyladenine inhibits transport from late endosomes to mature lysosomes in both rat and mouse fibroblasts.	3-methyladenine	129-144	cathepsin L	Rattus norvegicus	103-114
8110764-0	1994	1,N6-ethenoadenine is preferred over 3-methyladenine as substrate by a cloned human N-methylpurine-DNA glycosylase (3-methyladenine-DNA glycosylase).	3-methyladenine	37-52	N-methylpurine DNA glycosylase	Homo sapiens	116-147
8223512-10	1993	Increased repair of 3-methyladenine and 7-methylguanine in CHO cells that overexpress the N-methylpurine-DNA glycosylase (MPG) after transfection with the human MPG-cDNA did not give rise to protection against methylation-induced SCEs and aberrations, probably because of incomplete excision repair.	3-methyladenine	20-35	DNA-3-methyladenine glycosylase	Cricetulus griseus	122-125
8223512-10	1993	Increased repair of 3-methyladenine and 7-methylguanine in CHO cells that overexpress the N-methylpurine-DNA glycosylase (MPG) after transfection with the human MPG-cDNA did not give rise to protection against methylation-induced SCEs and aberrations, probably because of incomplete excision repair.	3-methyladenine	20-35	N-methylpurine DNA glycosylase	Homo sapiens	161-164
1423866-4	1992	The in vivo removal of 3-methyladenine and 7-methylguanine from some of these lines was analyzed and was observed to reflect their MPG levels.	3-methyladenine	23-38	DNA-3-methyladenine glycosylase	Cricetulus griseus	131-134
1409645-3	1992	We now find that this enzyme also releases 3-methyladenine from methylated DNA and that 3-methyladenine-DNA glycosylase behaves in the same manner, binding to the ethenoadenine-containing oligonucleotide and cleaving both ethenoadenine and 3-methyladenine from DNA containing these adducts.	3-methyladenine	43-58	N-methylpurine DNA glycosylase	Homo sapiens	88-119
1730806-3	1992	At 2.5 mM Ca, two inhibitors of cellular proteolysis, 3-methyladenine and chloroquine, stimulated secretion of both PA activity and PTH.	3-methyladenine	54-69	parathyroid hormone	Homo sapiens	132-135
1874728-3	1991	The human cDNA-encoded MPG releases 3-methyladenine, 7-methylguanine, and 3-methylguanine from DNA and thus has a substrate range similar to that of the indigenous enzyme and the E. coli AlkA protein.	3-methyladenine	36-51	N-methylpurine DNA glycosylase	Homo sapiens	23-26
1997198-3	1991	High performance liquid chromatography profiles of the bases which are released by these extracts show that the activity is specific for 3-methyladenine, suggesting that the resistant cells contain elevated levels of 3-methyladenine DNA glycosylase.	3-methyladenine	137-152	N-methylpurine DNA glycosylase	Homo sapiens	217-248
2109681-3	1990	PA secretion at high [Ca], like that of PTH, was increased by treatment of cells with chloroquine and/or 3-methyladenine.	3-methyladenine	105-120	parathyroid hormone	Bos taurus	40-43
33590832-9	2021	Importantly, autophagy restoration by 3MA (an autophagy inhibitor) treatment partially rescued developmental defects of METTL3 knockdown blastocysts.	3-methyladenine	38-41	methyltransferase like 3	Mus musculus	120-126
33798448-7	2021	We revealed that MSC-derived IL-15 activated MAIT cells by enhancing autophagy activity, which was abolished by the autophagy inhibitor 3-methyladenine.	3-methyladenine	136-151	interleukin 15	Homo sapiens	29-34
33034415-15	2021	The results showed that when 3-MA and BafA1 were applied, the promotion of autophagy by zinc was blocked and that the inhibitory effect of zinc on NLRP3 was reversed.	3-methyladenine	29-33	NLR family, pyrin domain containing 3	Mus musculus	147-152
33819192-11	2021	3-Methyladenine (3-MA) significantly inhibited FAM134B and LC3-II/I expression and promoted myocardial injury, inflammation response, and cardiomyocyte apoptosis.	3-methyladenine	0-15	reticulophagy regulator 1	Mus musculus	47-54
33819192-11	2021	3-Methyladenine (3-MA) significantly inhibited FAM134B and LC3-II/I expression and promoted myocardial injury, inflammation response, and cardiomyocyte apoptosis.	3-methyladenine	17-21	reticulophagy regulator 1	Mus musculus	47-54
33771228-8	2021	Blocking autophagy through 3-methyladenine and ammonium chloride treatment restored IKKbeta and IKKgamma protein levels and increased nitric oxide synthase production in LPS-stimulated AR-deficient macrophages.	3-methyladenine	27-42	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	84-91
33771228-8	2021	Blocking autophagy through 3-methyladenine and ammonium chloride treatment restored IKKbeta and IKKgamma protein levels and increased nitric oxide synthase production in LPS-stimulated AR-deficient macrophages.	3-methyladenine	27-42	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	96-104
33771228-8	2021	Blocking autophagy through 3-methyladenine and ammonium chloride treatment restored IKKbeta and IKKgamma protein levels and increased nitric oxide synthase production in LPS-stimulated AR-deficient macrophages.	3-methyladenine	27-42	aldo-keto reductase family 1 member B	Homo sapiens	185-187
33766785-6	2021	This hepatoprotective effects was dependent on enhanced autophagy in Dj-1 knockout mice, because inhibition of autophagy by 3-Methyladenine (3-MA) and chloroquine (CQ) could reverse the protective effect on hepatic I/R injury in Dj-1 knockout mice CONCLUSION: Dj-1 deficiency in hepatocytes significantly enhanced mitochondrial accumulation and protein stability of PARKIN, which in turn promotes the onset of mitophagy resulting in elevated clearance of damaged mitochondria during I/R injury.	3-methyladenine	124-139	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	69-73
33766785-6	2021	This hepatoprotective effects was dependent on enhanced autophagy in Dj-1 knockout mice, because inhibition of autophagy by 3-Methyladenine (3-MA) and chloroquine (CQ) could reverse the protective effect on hepatic I/R injury in Dj-1 knockout mice CONCLUSION: Dj-1 deficiency in hepatocytes significantly enhanced mitochondrial accumulation and protein stability of PARKIN, which in turn promotes the onset of mitophagy resulting in elevated clearance of damaged mitochondria during I/R injury.	3-methyladenine	141-145	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	69-73
33766785-6	2021	This hepatoprotective effects was dependent on enhanced autophagy in Dj-1 knockout mice, because inhibition of autophagy by 3-Methyladenine (3-MA) and chloroquine (CQ) could reverse the protective effect on hepatic I/R injury in Dj-1 knockout mice CONCLUSION: Dj-1 deficiency in hepatocytes significantly enhanced mitochondrial accumulation and protein stability of PARKIN, which in turn promotes the onset of mitophagy resulting in elevated clearance of damaged mitochondria during I/R injury.	3-methyladenine	141-145	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	229-233
33766785-6	2021	This hepatoprotective effects was dependent on enhanced autophagy in Dj-1 knockout mice, because inhibition of autophagy by 3-Methyladenine (3-MA) and chloroquine (CQ) could reverse the protective effect on hepatic I/R injury in Dj-1 knockout mice CONCLUSION: Dj-1 deficiency in hepatocytes significantly enhanced mitochondrial accumulation and protein stability of PARKIN, which in turn promotes the onset of mitophagy resulting in elevated clearance of damaged mitochondria during I/R injury.	3-methyladenine	141-145	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	229-233
33777755-10	2021	The AKT activator SC79 and autophagy inhibitor 3-methyladenine (3-MA) reversed the bupivacaine-inhibited phosphorylation of AKT and mTOR and bupivacaine-induced autophagy, as well as the bupivacaine-attenuated NSCLC progression in the cells.	3-methyladenine	47-62	AKT serine/threonine kinase 1	Homo sapiens	124-127
33777755-10	2021	The AKT activator SC79 and autophagy inhibitor 3-methyladenine (3-MA) reversed the bupivacaine-inhibited phosphorylation of AKT and mTOR and bupivacaine-induced autophagy, as well as the bupivacaine-attenuated NSCLC progression in the cells.	3-methyladenine	47-62	mechanistic target of rapamycin kinase	Homo sapiens	132-136
33777755-10	2021	The AKT activator SC79 and autophagy inhibitor 3-methyladenine (3-MA) reversed the bupivacaine-inhibited phosphorylation of AKT and mTOR and bupivacaine-induced autophagy, as well as the bupivacaine-attenuated NSCLC progression in the cells.	3-methyladenine	64-68	AKT serine/threonine kinase 1	Homo sapiens	4-7
33777755-10	2021	The AKT activator SC79 and autophagy inhibitor 3-methyladenine (3-MA) reversed the bupivacaine-inhibited phosphorylation of AKT and mTOR and bupivacaine-induced autophagy, as well as the bupivacaine-attenuated NSCLC progression in the cells.	3-methyladenine	64-68	AKT serine/threonine kinase 1	Homo sapiens	124-127
33777755-10	2021	The AKT activator SC79 and autophagy inhibitor 3-methyladenine (3-MA) reversed the bupivacaine-inhibited phosphorylation of AKT and mTOR and bupivacaine-induced autophagy, as well as the bupivacaine-attenuated NSCLC progression in the cells.	3-methyladenine	64-68	mechanistic target of rapamycin kinase	Homo sapiens	132-136
33800526-8	2021	Likewise, pretreatment with the autophagy inhibitor, 3-methyladenine (3-MA), resulted in significantly fewer OxyR-induced LC3 puncta and lower LC3-II expression, suggesting that OxyR-mediated autophagy was dependent on the class III PI3-kinase pathway.	3-methyladenine	53-68	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	122-125
33800526-8	2021	Likewise, pretreatment with the autophagy inhibitor, 3-methyladenine (3-MA), resulted in significantly fewer OxyR-induced LC3 puncta and lower LC3-II expression, suggesting that OxyR-mediated autophagy was dependent on the class III PI3-kinase pathway.	3-methyladenine	53-68	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	143-146
33800526-8	2021	Likewise, pretreatment with the autophagy inhibitor, 3-methyladenine (3-MA), resulted in significantly fewer OxyR-induced LC3 puncta and lower LC3-II expression, suggesting that OxyR-mediated autophagy was dependent on the class III PI3-kinase pathway.	3-methyladenine	70-74	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	122-125
33800526-8	2021	Likewise, pretreatment with the autophagy inhibitor, 3-methyladenine (3-MA), resulted in significantly fewer OxyR-induced LC3 puncta and lower LC3-II expression, suggesting that OxyR-mediated autophagy was dependent on the class III PI3-kinase pathway.	3-methyladenine	70-74	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	143-146
24024664-7	2013	We also found that 3-MA can enhance the growth inhibition and apoptotic effect of adriamycin in acquired resistant cells (K562/ADM).	3-methyladenine	19-23	adrenomedullin	Homo sapiens	127-130
34953929-6	2022	However, 3-MA (15mg/kg) treatment downregulated the inhibitory effect of Platonin on NLRP3 inflammasomes.	3-methyladenine	9-13	NLR family, pyrin domain containing 3	Rattus norvegicus	85-90
34289309-11	2022	Furthermore, CD142 silencing-induced IL-8 degradation was recovered by treatment of autophagy inhibitor 3-MA.	3-methyladenine	104-108	coagulation factor III, tissue factor	Homo sapiens	13-18
34289309-11	2022	Furthermore, CD142 silencing-induced IL-8 degradation was recovered by treatment of autophagy inhibitor 3-MA.	3-methyladenine	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
34614219-4	2022	The effect of TFEB overexpression on GLUT4 was also abolished by the autophagy inhibitor 3-MA.	3-methyladenine	89-93	transcription factor EB	Homo sapiens	14-18
34614219-4	2022	The effect of TFEB overexpression on GLUT4 was also abolished by the autophagy inhibitor 3-MA.	3-methyladenine	89-93	solute carrier family 2 member 4	Homo sapiens	37-42
34802165-7	2022	SC79 and 3MA significantly downregulated the ratio of LC3I/LC3II but increased the level of p62 in NLRC5 + Ang II-treated cells.	3-methyladenine	9-12	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	54-58
34802165-7	2022	SC79 and 3MA significantly downregulated the ratio of LC3I/LC3II but increased the level of p62 in NLRC5 + Ang II-treated cells.	3-methyladenine	9-12	sequestosome 1	Homo sapiens	92-95
34802165-7	2022	SC79 and 3MA significantly downregulated the ratio of LC3I/LC3II but increased the level of p62 in NLRC5 + Ang II-treated cells.	3-methyladenine	9-12	NLR family CARD domain containing 5	Homo sapiens	99-104
34802165-7	2022	SC79 and 3MA significantly downregulated the ratio of LC3I/LC3II but increased the level of p62 in NLRC5 + Ang II-treated cells.	3-methyladenine	9-12	angiotensinogen	Rattus norvegicus	107-113
34520828-7	2022	The pretreatment of autophagy inhibitor 3-MA decreased markedly autophagosomes and protein expression levels of LC3 and Beclin-1, which suggested that aconitine could induce cell autophagy.	3-methyladenine	40-44	annexin A3	Rattus norvegicus	112-115
34520828-7	2022	The pretreatment of autophagy inhibitor 3-MA decreased markedly autophagosomes and protein expression levels of LC3 and Beclin-1, which suggested that aconitine could induce cell autophagy.	3-methyladenine	40-44	beclin 1	Rattus norvegicus	120-128
34695452-11	2022	Additionally, treatment with 3-MA abolished the beneficial effect of GPNMB on Abeta clearance.	3-methyladenine	29-33	glycoprotein (transmembrane) nmb	Mus musculus	69-74
34695452-11	2022	Additionally, treatment with 3-MA abolished the beneficial effect of GPNMB on Abeta clearance.	3-methyladenine	29-33	amyloid beta (A4) precursor protein	Mus musculus	78-83
34813965-14	2022	Furthermore, the promoting effect of PLC-gamma1 inhibition on ALP and OCN mRNA levels and absorbance values of ARS content was reversed by endoplasmic reticulum (ER) stress activator HA15, as well as autophagic inhibitors CQ and 3MA.	3-methyladenine	229-232	phospholipase C, gamma 1	Rattus norvegicus	37-47
34813965-14	2022	Furthermore, the promoting effect of PLC-gamma1 inhibition on ALP and OCN mRNA levels and absorbance values of ARS content was reversed by endoplasmic reticulum (ER) stress activator HA15, as well as autophagic inhibitors CQ and 3MA.	3-methyladenine	229-232	PDZ and LIM domain 3	Rattus norvegicus	62-65
34598317-12	2022	3-MA reversed the effect of RAD001 on FaDu tumor growth suggesting that RAD001 promotes ACDC in HPV-negative mutTP53 xenograft.	3-methyladenine	0-4	adiponectin, C1Q and collagen domain containing	Homo sapiens	88-92
34922208-10	2022	Moreover, the effects of NIS on cells were enhanced by autophagy activator Rapamycin whereas reversed by autophagy inhibitor 3-Methyladenine (3-MA).	3-methyladenine	125-140	solute carrier family 5 member 5	Homo sapiens	25-28
34922208-10	2022	Moreover, the effects of NIS on cells were enhanced by autophagy activator Rapamycin whereas reversed by autophagy inhibitor 3-Methyladenine (3-MA).	3-methyladenine	142-146	solute carrier family 5 member 5	Homo sapiens	25-28
34938341-9	2021	MDC-positive cells and autophagosomes were reduced by ZnS or 3-MA treatment.	3-methyladenine	61-65	C-C motif chemokine ligand 22	Homo sapiens	0-3
34938341-10	2021	The expression of autophagy-related proteins LC3 (LC3II/LC3I) and P62 was, respectively, downregulated and upregulated after ZnS or 3-MA treatment.	3-methyladenine	132-136	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	45-48
34938341-10	2021	The expression of autophagy-related proteins LC3 (LC3II/LC3I) and P62 was, respectively, downregulated and upregulated after ZnS or 3-MA treatment.	3-methyladenine	132-136	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	50-60
34938341-11	2021	In addition, ZnS or 3-MA suppressed the protein expression of AKR1C1, p-JAK2, and p-STAT3 in HCC cells.	3-methyladenine	20-24	aldo-keto reductase family 1 member C1	Homo sapiens	62-68
34938341-11	2021	In addition, ZnS or 3-MA suppressed the protein expression of AKR1C1, p-JAK2, and p-STAT3 in HCC cells.	3-methyladenine	20-24	Janus kinase 2	Homo sapiens	72-76
34938341-11	2021	In addition, ZnS or 3-MA suppressed the protein expression of AKR1C1, p-JAK2, and p-STAT3 in HCC cells.	3-methyladenine	20-24	signal transducer and activator of transcription 3	Homo sapiens	84-89
34873651-5	2021	The cell apoptosis rate and poly ADP-ribose polymerase (PARP) and caspase-3 activities were increased in GES-1 cells pretreated with 3-methyladenine (3-MA ) after H. pylori infection.	3-methyladenine	133-148	poly(ADP-ribose) polymerase 1	Homo sapiens	28-54
34873651-5	2021	The cell apoptosis rate and poly ADP-ribose polymerase (PARP) and caspase-3 activities were increased in GES-1 cells pretreated with 3-methyladenine (3-MA ) after H. pylori infection.	3-methyladenine	133-148	poly(ADP-ribose) polymerase 1	Homo sapiens	56-60
34873651-5	2021	The cell apoptosis rate and poly ADP-ribose polymerase (PARP) and caspase-3 activities were increased in GES-1 cells pretreated with 3-methyladenine (3-MA ) after H. pylori infection.	3-methyladenine	133-148	caspase 3	Homo sapiens	66-75
34873651-5	2021	The cell apoptosis rate and poly ADP-ribose polymerase (PARP) and caspase-3 activities were increased in GES-1 cells pretreated with 3-methyladenine (3-MA ) after H. pylori infection.	3-methyladenine	150-154	poly(ADP-ribose) polymerase 1	Homo sapiens	28-54
34873651-5	2021	The cell apoptosis rate and poly ADP-ribose polymerase (PARP) and caspase-3 activities were increased in GES-1 cells pretreated with 3-methyladenine (3-MA ) after H. pylori infection.	3-methyladenine	150-154	poly(ADP-ribose) polymerase 1	Homo sapiens	56-60
34873651-5	2021	The cell apoptosis rate and poly ADP-ribose polymerase (PARP) and caspase-3 activities were increased in GES-1 cells pretreated with 3-methyladenine (3-MA ) after H. pylori infection.	3-methyladenine	150-154	caspase 3	Homo sapiens	66-75
34167449-7	2021	The apoptotic rate of OA chondrocytes was markedly elevated by 3-methyladenine and suppressed by rapamycin and icariin; autophagy genes were drastically downregulated in the 3-methyladenine group and upregulated in the rapamycin and icariin groups; and the PI3K/AKT/mTOR signaling pathway was activated by 3-methyladenine and inhibited by rapamycin and icariin.	3-methyladenine	63-78	AKT serine/threonine kinase 1	Rattus norvegicus	262-265
34167449-7	2021	The apoptotic rate of OA chondrocytes was markedly elevated by 3-methyladenine and suppressed by rapamycin and icariin; autophagy genes were drastically downregulated in the 3-methyladenine group and upregulated in the rapamycin and icariin groups; and the PI3K/AKT/mTOR signaling pathway was activated by 3-methyladenine and inhibited by rapamycin and icariin.	3-methyladenine	63-78	mechanistic target of rapamycin kinase	Rattus norvegicus	266-270
34167449-7	2021	The apoptotic rate of OA chondrocytes was markedly elevated by 3-methyladenine and suppressed by rapamycin and icariin; autophagy genes were drastically downregulated in the 3-methyladenine group and upregulated in the rapamycin and icariin groups; and the PI3K/AKT/mTOR signaling pathway was activated by 3-methyladenine and inhibited by rapamycin and icariin.	3-methyladenine	174-189	AKT serine/threonine kinase 1	Rattus norvegicus	262-265
34167449-7	2021	The apoptotic rate of OA chondrocytes was markedly elevated by 3-methyladenine and suppressed by rapamycin and icariin; autophagy genes were drastically downregulated in the 3-methyladenine group and upregulated in the rapamycin and icariin groups; and the PI3K/AKT/mTOR signaling pathway was activated by 3-methyladenine and inhibited by rapamycin and icariin.	3-methyladenine	174-189	mechanistic target of rapamycin kinase	Rattus norvegicus	266-270
34167449-7	2021	The apoptotic rate of OA chondrocytes was markedly elevated by 3-methyladenine and suppressed by rapamycin and icariin; autophagy genes were drastically downregulated in the 3-methyladenine group and upregulated in the rapamycin and icariin groups; and the PI3K/AKT/mTOR signaling pathway was activated by 3-methyladenine and inhibited by rapamycin and icariin.	3-methyladenine	306-321	AKT serine/threonine kinase 1	Rattus norvegicus	262-265
34167449-7	2021	The apoptotic rate of OA chondrocytes was markedly elevated by 3-methyladenine and suppressed by rapamycin and icariin; autophagy genes were drastically downregulated in the 3-methyladenine group and upregulated in the rapamycin and icariin groups; and the PI3K/AKT/mTOR signaling pathway was activated by 3-methyladenine and inhibited by rapamycin and icariin.	3-methyladenine	306-321	mechanistic target of rapamycin kinase	Rattus norvegicus	266-270
34509161-9	2021	The effect of the inhibitor 3-methyladenine (3-MA) on roots and leaves of wheat seedlings was in accordance with that of ATG2 and ATG7 silencing.	3-methyladenine	28-43	autophagy related 7	Homo sapiens	130-134
34509161-9	2021	The effect of the inhibitor 3-methyladenine (3-MA) on roots and leaves of wheat seedlings was in accordance with that of ATG2 and ATG7 silencing.	3-methyladenine	45-49	autophagy related 7	Homo sapiens	130-134
34525858-5	2021	Furthermore, the inhibition effect of D4F on gly-HDL-induced ER stress-CHOP-induced apoptosis of macrophages was restrained after beclin-1 siRNA and 3-methyladenine (3-MA, an inhibitor of autophagy) treatments, while this effect was further reinforced after rapamycin (Rapa, an inducer of autophagy) treatment.	3-methyladenine	149-164	DNA-damage inducible transcript 3	Mus musculus	71-75
34525858-5	2021	Furthermore, the inhibition effect of D4F on gly-HDL-induced ER stress-CHOP-induced apoptosis of macrophages was restrained after beclin-1 siRNA and 3-methyladenine (3-MA, an inhibitor of autophagy) treatments, while this effect was further reinforced after rapamycin (Rapa, an inducer of autophagy) treatment.	3-methyladenine	166-170	DNA-damage inducible transcript 3	Mus musculus	71-75
34848256-8	2021	In Lamp2-knock down cells, pathologic alpha-synuclein was increased 12 h after DQ treatment, but there was no change observed at 24 h. In DQ-treated cells, macroautophagy by 3-methyladenine and bafilomycin inhibition increased Lamp2A expression, indicating an increase in CMA activity.	3-methyladenine	174-189	lysosomal associated membrane protein 2	Homo sapiens	3-8
34848256-8	2021	In Lamp2-knock down cells, pathologic alpha-synuclein was increased 12 h after DQ treatment, but there was no change observed at 24 h. In DQ-treated cells, macroautophagy by 3-methyladenine and bafilomycin inhibition increased Lamp2A expression, indicating an increase in CMA activity.	3-methyladenine	174-189	synuclein alpha	Homo sapiens	38-53
34710506-7	2021	3MA (autophagy inhibitor) attenuated the effects of AURKA on AIM2 inflammasome.	3-methyladenine	0-3	aurora kinase A	Homo sapiens	52-57
34710506-7	2021	3MA (autophagy inhibitor) attenuated the effects of AURKA on AIM2 inflammasome.	3-methyladenine	0-3	absent in melanoma 2	Homo sapiens	61-65
34608496-2	2021	Firstly, the expression of lncRNA GAS5 during cell starvation or following treatment with 3-methyladenine was determined using reverse transcription-quantitative PCR (RT-qPCR).	3-methyladenine	90-105	growth arrest specific 5	Mus musculus	34-38
34735906-11	2021	More importantly, autophagy inhibitor 3-MA diminished the inhibitory effect of KXS on NLRP3 inflammasome activation in rat astrocytes.	3-methyladenine	38-42	NLR family, pyrin domain containing 3	Rattus norvegicus	86-91
34951247-9	2021	The addition of 3-MA had no effect on the expression of SIRT1 protein, but the expression of SIRT1 and LC3-II proteins decreased and the expression of p62 increased after the addition of EX-527.	3-methyladenine	16-20	sirtuin 1	Homo sapiens	93-98
34951247-9	2021	The addition of 3-MA had no effect on the expression of SIRT1 protein, but the expression of SIRT1 and LC3-II proteins decreased and the expression of p62 increased after the addition of EX-527.	3-methyladenine	16-20	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	103-106
34951247-9	2021	The addition of 3-MA had no effect on the expression of SIRT1 protein, but the expression of SIRT1 and LC3-II proteins decreased and the expression of p62 increased after the addition of EX-527.	3-methyladenine	16-20	nucleoporin 62	Homo sapiens	151-154
34736532-10	2021	The addition of AMPK inhibitor Compound C or autophagy inhibitor 3-MA inhibited the osteogenesis of rBMSCs in high-glucose condition, suggesting that PPARbeta/delta agonist promotes osteogenic differentiation of rBMSCs through AMPK/mTOR-regulated autophagy.	3-methyladenine	65-69	peroxisome proliferator activated receptor alpha	Rattus norvegicus	150-164
34736532-10	2021	The addition of AMPK inhibitor Compound C or autophagy inhibitor 3-MA inhibited the osteogenesis of rBMSCs in high-glucose condition, suggesting that PPARbeta/delta agonist promotes osteogenic differentiation of rBMSCs through AMPK/mTOR-regulated autophagy.	3-methyladenine	65-69	mechanistic target of rapamycin kinase	Rattus norvegicus	232-236
34500038-14	2021	Treatment with autophagy inhibitor (3-MA) abolished the protective effects of GATA3 against OGD-induced cell injury.	3-methyladenine	36-40	GATA binding protein 3	Rattus norvegicus	78-83
34939754-10	2021	Expression of INSULIN and GLUT-2 genes (P<0.01 and P<0.05, respectively), insulin secretion in response to glucose (P<0.01), and percentage of NG-positive cells (P<0.05) in the 3MA-exposed cells were considerably lower than the cells treated with CDM.	3-methyladenine	177-180	insulin	Homo sapiens	14-21
34939754-10	2021	Expression of INSULIN and GLUT-2 genes (P<0.01 and P<0.05, respectively), insulin secretion in response to glucose (P<0.01), and percentage of NG-positive cells (P<0.05) in the 3MA-exposed cells were considerably lower than the cells treated with CDM.	3-methyladenine	177-180	solute carrier family 2 member 2	Homo sapiens	26-32
34939754-10	2021	Expression of INSULIN and GLUT-2 genes (P<0.01 and P<0.05, respectively), insulin secretion in response to glucose (P<0.01), and percentage of NG-positive cells (P<0.05) in the 3MA-exposed cells were considerably lower than the cells treated with CDM.	3-methyladenine	177-180	insulin	Homo sapiens	74-81
34939754-13	2021	Conclusion: Our data showed that autophagy is necessary for beta-cell differentiation, and preventing autophagy by 3MA causes the reduction of beta-cell differentiation and insulin secretion.	3-methyladenine	115-118	insulin	Homo sapiens	173-180
34603530-13	2021	The knockdown effects of NF1-siRNA on the autophagy and osteogenic differentiation of BMSCs were reversed by the autophagy activator RAPA, while the overexpression effects of NF1-pcDNA3.0 on the autophagy and osteogenic differentiation of BMSCs were reversed by the autophagy inhibitor 3-MA.	3-methyladenine	286-290	neurofibromin 1	Homo sapiens	25-28
34603530-13	2021	The knockdown effects of NF1-siRNA on the autophagy and osteogenic differentiation of BMSCs were reversed by the autophagy activator RAPA, while the overexpression effects of NF1-pcDNA3.0 on the autophagy and osteogenic differentiation of BMSCs were reversed by the autophagy inhibitor 3-MA.	3-methyladenine	286-290	neurofibromin 1	Homo sapiens	175-178
34530204-12	2021	The addition of exogenous GGPP (synthesis products catalyzed by GGPPS1) and autophagic inhibitor 3-MA aggravated sepsis-induced hypoxemia, alveolar inflammatory response, intrapulmonary hemorrhage, and pulmonary edema, as evidenced by increased lung injury score, lung wet/dry weight ratio, MPO activity, total protein content, total cell, and PMNs counts, and decreased PaO2/FiO2 ratio.	3-methyladenine	97-101	myeloperoxidase	Mus musculus	291-294
34530204-15	2021	Inhibition of autophagy by 3-MA treatment also promoted the activity of NLRP3 inflammasome and the production of IL-1beta and IL-18.	3-methyladenine	27-31	NLR family, pyrin domain containing 3	Mus musculus	72-77
34530204-15	2021	Inhibition of autophagy by 3-MA treatment also promoted the activity of NLRP3 inflammasome and the production of IL-1beta and IL-18.	3-methyladenine	27-31	interleukin 1 alpha	Mus musculus	113-121
34530204-15	2021	Inhibition of autophagy by 3-MA treatment also promoted the activity of NLRP3 inflammasome and the production of IL-1beta and IL-18.	3-methyladenine	27-31	interleukin 18	Mus musculus	126-131
34537481-12	2021	The autophagy inhibitor 3-MA rescued the effects of 6-Gingerol on the NLRP3 inflammasome and apoptosis.	3-methyladenine	24-28	NLR family, pyrin domain containing 3	Rattus norvegicus	70-75
34423507-7	2021	However, blockade of autophagy by 3-methyladenine reversed the suppression of SY on NLRP3 inflammasome activation and the protection of SY on HK-2 cells.	3-methyladenine	34-49	NLR family pyrin domain containing 3	Homo sapiens	84-89
34339727-9	2021	When autophagy was inhibited by 3-MA or CQ, confirmed by corresponding changes of these indicators of autophagy, cellular proliferation, migration and tube formation of RF/6A cells were weakened by AGGF1 treatment when compared with that of AGGF1 treatment alone.	3-methyladenine	32-36	angiogenic factor with G patch and FHA domains 1	Macaca mulatta	198-203
34339727-9	2021	When autophagy was inhibited by 3-MA or CQ, confirmed by corresponding changes of these indicators of autophagy, cellular proliferation, migration and tube formation of RF/6A cells were weakened by AGGF1 treatment when compared with that of AGGF1 treatment alone.	3-methyladenine	32-36	angiogenic factor with G patch and FHA domains 1	Macaca mulatta	241-246
34238121-7	2021	Notably, the present study also indicates that autophagy inhibited by inhibitor 3-methyladenine (3MA) and siAtg7 exacerbate acrolein-induced NLRP3 inflammasome activation and pyroptosis.	3-methyladenine	80-95	NLR family pyrin domain containing 3	Homo sapiens	141-146
34238121-7	2021	Notably, the present study also indicates that autophagy inhibited by inhibitor 3-methyladenine (3MA) and siAtg7 exacerbate acrolein-induced NLRP3 inflammasome activation and pyroptosis.	3-methyladenine	97-100	NLR family pyrin domain containing 3	Homo sapiens	141-146
34565256-5	2021	The results showed that LPS induced NF-kappaB-related pulmonary inflammation in observers and silicosis patients, as confirmed by an increase in the expression of IL-1beta, IL-6, TNF-alpha, and p65, which could be inhibited by 3-MA treatment.	3-methyladenine	227-231	nuclear factor kappa B subunit 1	Homo sapiens	36-45
34565256-5	2021	The results showed that LPS induced NF-kappaB-related pulmonary inflammation in observers and silicosis patients, as confirmed by an increase in the expression of IL-1beta, IL-6, TNF-alpha, and p65, which could be inhibited by 3-MA treatment.	3-methyladenine	227-231	interleukin 1 alpha	Homo sapiens	163-171
34565256-5	2021	The results showed that LPS induced NF-kappaB-related pulmonary inflammation in observers and silicosis patients, as confirmed by an increase in the expression of IL-1beta, IL-6, TNF-alpha, and p65, which could be inhibited by 3-MA treatment.	3-methyladenine	227-231	interleukin 6	Homo sapiens	173-177
34565256-5	2021	The results showed that LPS induced NF-kappaB-related pulmonary inflammation in observers and silicosis patients, as confirmed by an increase in the expression of IL-1beta, IL-6, TNF-alpha, and p65, which could be inhibited by 3-MA treatment.	3-methyladenine	227-231	tumor necrosis factor	Homo sapiens	179-188
34565256-5	2021	The results showed that LPS induced NF-kappaB-related pulmonary inflammation in observers and silicosis patients, as confirmed by an increase in the expression of IL-1beta, IL-6, TNF-alpha, and p65, which could be inhibited by 3-MA treatment.	3-methyladenine	227-231	RELA proto-oncogene, NF-kB subunit	Homo sapiens	194-197
34565256-7	2021	Mechanism study revealed that LPS triggered the expression of LC3 II, p62, and cleaved caspase-3 at the early stage exposed to silica, which could be restored by 3-MA, while there was no difference in the expression of LAMP1 either at the early or late stage of silicosis in different groups.	3-methyladenine	162-166	nucleoporin 62	Homo sapiens	70-73
34565256-7	2021	Mechanism study revealed that LPS triggered the expression of LC3 II, p62, and cleaved caspase-3 at the early stage exposed to silica, which could be restored by 3-MA, while there was no difference in the expression of LAMP1 either at the early or late stage of silicosis in different groups.	3-methyladenine	162-166	caspase 3	Homo sapiens	87-96
34565256-8	2021	Similarly, 3-MA treatment did not prevent fibrosis characterized by destroyed alveoli, collagen deposition, and increased expression of alpha-SMA and Col-1 induced by LPS at the late stage of silicosis.	3-methyladenine	11-15	actin alpha 1, skeletal muscle	Homo sapiens	136-145
34712387-8	2021	Furthermore, the conducive influences exerted by GDF-11 were reversed with the application of 3-methyladenine (3MA), an autophagy suppressor, indicating that autophagy critically impacted the therapeutically related benefits of GDF-11 on recovery after SCI.	3-methyladenine	94-109	growth differentiation factor 11	Mus musculus	49-55
34712387-8	2021	Furthermore, the conducive influences exerted by GDF-11 were reversed with the application of 3-methyladenine (3MA), an autophagy suppressor, indicating that autophagy critically impacted the therapeutically related benefits of GDF-11 on recovery after SCI.	3-methyladenine	94-109	growth differentiation factor 11	Mus musculus	228-234
34712387-8	2021	Furthermore, the conducive influences exerted by GDF-11 were reversed with the application of 3-methyladenine (3MA), an autophagy suppressor, indicating that autophagy critically impacted the therapeutically related benefits of GDF-11 on recovery after SCI.	3-methyladenine	111-114	growth differentiation factor 11	Mus musculus	49-55
34712387-8	2021	Furthermore, the conducive influences exerted by GDF-11 were reversed with the application of 3-methyladenine (3MA), an autophagy suppressor, indicating that autophagy critically impacted the therapeutically related benefits of GDF-11 on recovery after SCI.	3-methyladenine	111-114	growth differentiation factor 11	Mus musculus	228-234
34508745-9	2021	miR-411 overexpression or autophagy blockage using 3-methyladenine (3-MA) relieved PM2.5-mediated cell proliferation and fibrosis-associated factor expression in HSCs.	3-methyladenine	51-66	microRNA 411	Homo sapiens	0-7
34676207-5	2021	Interestingly, ANXA6-exo increased PTX resistance in PS-BC cells via inducing autophagy, and the effects of ANXA6-exo on PTX resistance in PS-BC cells were abrogated by co-treating cells with the autophagy inhibitor 3-methyladenine.	3-methyladenine	216-231	annexin A6	Homo sapiens	15-20
34676207-5	2021	Interestingly, ANXA6-exo increased PTX resistance in PS-BC cells via inducing autophagy, and the effects of ANXA6-exo on PTX resistance in PS-BC cells were abrogated by co-treating cells with the autophagy inhibitor 3-methyladenine.	3-methyladenine	216-231	annexin A6	Homo sapiens	108-113
34602075-9	2021	However, either administration of 3-methyladenine (3-MA), an autophagy antagonist or knockdown of PINK1 reduced the protective action of adiponectin.	3-methyladenine	34-49	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	137-148
34602075-9	2021	However, either administration of 3-methyladenine (3-MA), an autophagy antagonist or knockdown of PINK1 reduced the protective action of adiponectin.	3-methyladenine	51-55	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	137-148
34547141-6	2021	Herein, treating with 3-MA markedly suppressed the expression of tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6, promoted that of IL-10, IL-33, and ST2, while RAP administration reverted SWH-induced the up-regulation of these inflammatory cytokines mentioned above.	3-methyladenine	22-26	tumor necrosis factor	Mus musculus	65-92
34547141-6	2021	Herein, treating with 3-MA markedly suppressed the expression of tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6, promoted that of IL-10, IL-33, and ST2, while RAP administration reverted SWH-induced the up-regulation of these inflammatory cytokines mentioned above.	3-methyladenine	22-26	tumor necrosis factor	Mus musculus	94-103
34547141-6	2021	Herein, treating with 3-MA markedly suppressed the expression of tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6, promoted that of IL-10, IL-33, and ST2, while RAP administration reverted SWH-induced the up-regulation of these inflammatory cytokines mentioned above.	3-methyladenine	22-26	interleukin 1 alpha	Mus musculus	106-114
34547141-6	2021	Herein, treating with 3-MA markedly suppressed the expression of tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6, promoted that of IL-10, IL-33, and ST2, while RAP administration reverted SWH-induced the up-regulation of these inflammatory cytokines mentioned above.	3-methyladenine	22-26	interleukin 6	Mus musculus	120-124
34547141-6	2021	Herein, treating with 3-MA markedly suppressed the expression of tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6, promoted that of IL-10, IL-33, and ST2, while RAP administration reverted SWH-induced the up-regulation of these inflammatory cytokines mentioned above.	3-methyladenine	22-26	interleukin 10	Mus musculus	143-148
34547141-6	2021	Herein, treating with 3-MA markedly suppressed the expression of tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6, promoted that of IL-10, IL-33, and ST2, while RAP administration reverted SWH-induced the up-regulation of these inflammatory cytokines mentioned above.	3-methyladenine	22-26	interleukin 33	Mus musculus	150-155
34547141-6	2021	Herein, treating with 3-MA markedly suppressed the expression of tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6, promoted that of IL-10, IL-33, and ST2, while RAP administration reverted SWH-induced the up-regulation of these inflammatory cytokines mentioned above.	3-methyladenine	22-26	interleukin 1 receptor-like 1	Mus musculus	161-164
34547141-10	2021	Moreover, 3-MA in combination with anti-IL-33 treatment reversed the role of 3-MA alone in mitigated pathological changes, but they failed to revert the effect of anti-IL-33 alone on worsening pathological damage.	3-methyladenine	10-14	interleukin 33	Mus musculus	168-173
34547141-10	2021	Moreover, 3-MA in combination with anti-IL-33 treatment reversed the role of 3-MA alone in mitigated pathological changes, but they failed to revert the effect of anti-IL-33 alone on worsening pathological damage.	3-methyladenine	77-81	interleukin 33	Mus musculus	40-45
34457046-13	2021	The cell cycle was arrested at the G1 phase, the number of early apoptotic cells increased and the protein expression level of cleaved caspase-3 increased, while penicillin-induced apoptosis was blocked by the autophagy inhibitor 3-MA.	3-methyladenine	230-234	caspase 3	Homo sapiens	135-144
34481905-10	2021	Inhibition of autophagy by 3-Methyladenine (3MA, 3 mM) elucidated an essential role of autophagy in HMGA2-induced glycolysis, migration, and HMGA2-reduced OXPHOS.	3-methyladenine	27-42	high mobility group AT-hook 2	Homo sapiens	100-105
34481905-10	2021	Inhibition of autophagy by 3-Methyladenine (3MA, 3 mM) elucidated an essential role of autophagy in HMGA2-induced glycolysis, migration, and HMGA2-reduced OXPHOS.	3-methyladenine	44-47	high mobility group AT-hook 2	Homo sapiens	100-105
34481905-10	2021	Inhibition of autophagy by 3-Methyladenine (3MA, 3 mM) elucidated an essential role of autophagy in HMGA2-induced glycolysis, migration, and HMGA2-reduced OXPHOS.	3-methyladenine	44-47	high mobility group AT-hook 2	Homo sapiens	141-146
34127226-4	2021	Further studies show that fucoidan promotes autophagy showed by the expression of p62/SQSTM1 and microtubule-associated protein light chain 3 (LC3) II, which can be blocked by autophagy inhibitors 3-MA and bafilomycin A1.	3-methyladenine	197-201	sequestosome 1	Homo sapiens	82-85
34127226-4	2021	Further studies show that fucoidan promotes autophagy showed by the expression of p62/SQSTM1 and microtubule-associated protein light chain 3 (LC3) II, which can be blocked by autophagy inhibitors 3-MA and bafilomycin A1.	3-methyladenine	197-201	sequestosome 1	Homo sapiens	86-92
34127226-4	2021	Further studies show that fucoidan promotes autophagy showed by the expression of p62/SQSTM1 and microtubule-associated protein light chain 3 (LC3) II, which can be blocked by autophagy inhibitors 3-MA and bafilomycin A1.	3-methyladenine	197-201	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	143-146
34526526-7	2021	The alk-BER assay involves specific detection of methyl DNA adducts (7-methyl guanine and 3-methyl adenine) directly in genomic DNA.	3-methyladenine	90-106	ALK receptor tyrosine kinase	Homo sapiens	4-7
34572575-5	2021	Herein, we introduce an anti-cell adaptation strategy based on dendritic mesoporous organosilica nanoparticles (DMONs) loaded with GOx and 3-methyladenine (3-MA) (an autophagy inhibition agent) to yield DMON@GOx/3-MA.	3-methyladenine	139-154	hydroxyacid oxidase 1	Homo sapiens	208-211
34572575-5	2021	Herein, we introduce an anti-cell adaptation strategy based on dendritic mesoporous organosilica nanoparticles (DMONs) loaded with GOx and 3-methyladenine (3-MA) (an autophagy inhibition agent) to yield DMON@GOx/3-MA.	3-methyladenine	156-160	hydroxyacid oxidase 1	Homo sapiens	131-134
34572575-5	2021	Herein, we introduce an anti-cell adaptation strategy based on dendritic mesoporous organosilica nanoparticles (DMONs) loaded with GOx and 3-methyladenine (3-MA) (an autophagy inhibition agent) to yield DMON@GOx/3-MA.	3-methyladenine	156-160	hydroxyacid oxidase 1	Homo sapiens	208-211
34734026-6	2021	Results: Autophagy inhibitor 3-MA suppressed the Beclin-1 and ATG5 protein levels and the ratio of LC3-II to LC3-I, as well as autophagosome formation in RAW264.7 transfected with the MUT plasmid and enhanced p62 protein expression.	3-methyladenine	29-33	beclin 1	Homo sapiens	49-57
34734026-6	2021	Results: Autophagy inhibitor 3-MA suppressed the Beclin-1 and ATG5 protein levels and the ratio of LC3-II to LC3-I, as well as autophagosome formation in RAW264.7 transfected with the MUT plasmid and enhanced p62 protein expression.	3-methyladenine	29-33	autophagy related 5	Homo sapiens	62-66
34734026-6	2021	Results: Autophagy inhibitor 3-MA suppressed the Beclin-1 and ATG5 protein levels and the ratio of LC3-II to LC3-I, as well as autophagosome formation in RAW264.7 transfected with the MUT plasmid and enhanced p62 protein expression.	3-methyladenine	29-33	nucleoporin 62	Homo sapiens	209-212
34734026-8	2021	In addition, 3-MA inhibited osteoclast-related protein and mRNA expression, including NFATC1, ACP5, CTSK.	3-methyladenine	13-17	nuclear factor of activated T cells 1	Homo sapiens	86-92
34734026-8	2021	In addition, 3-MA inhibited osteoclast-related protein and mRNA expression, including NFATC1, ACP5, CTSK.	3-methyladenine	13-17	acid phosphatase 5, tartrate resistant	Homo sapiens	94-98
34734026-8	2021	In addition, 3-MA inhibited osteoclast-related protein and mRNA expression, including NFATC1, ACP5, CTSK.	3-methyladenine	13-17	cathepsin K	Homo sapiens	100-104
34734026-9	2021	And the autophagy-related pathway protein p-AMPKalpha was increased and p-mTOR was reduced by 3-MA treatment.	3-methyladenine	94-98	mechanistic target of rapamycin kinase	Homo sapiens	74-78
34268882-10	2021	Suppression of autophagy by 3MA reversed the expression of paxillin and its phosphorylation in SphK1-overexpressed CRC cells, indicated that SphK1-driven autophagy induced the expression of paxillin and its phosphorylation in CRC cells.	3-methyladenine	28-31	paxillin	Mus musculus	59-67
34268882-10	2021	Suppression of autophagy by 3MA reversed the expression of paxillin and its phosphorylation in SphK1-overexpressed CRC cells, indicated that SphK1-driven autophagy induced the expression of paxillin and its phosphorylation in CRC cells.	3-methyladenine	28-31	sphingosine kinase 1	Mus musculus	95-100
34268882-10	2021	Suppression of autophagy by 3MA reversed the expression of paxillin and its phosphorylation in SphK1-overexpressed CRC cells, indicated that SphK1-driven autophagy induced the expression of paxillin and its phosphorylation in CRC cells.	3-methyladenine	28-31	paxillin	Mus musculus	190-198
34242720-7	2021	Furthermore, Rapa pretreatment antagonized MeHg-induced apoptosis, whereas 3-MA further aggravated apoptosis, which were supported by findings that Rapa activated mTOR-mediated autophagy while 3-MA inhibited Vps34-related autophagy, further affect neuronal apoptosis through regulation of apoptotic factors mentioned above.	3-methyladenine	75-79	mechanistic target of rapamycin kinase	Rattus norvegicus	163-167
34298019-12	2021	L-PGRN blunted the autophagic response to NMDA and occluded the protective effect of 3-methyladenine.	3-methyladenine	85-100	granulin precursor	Rattus norvegicus	2-6
34309113-10	2021	Moreover, LTX-315 promoted Beclin-1 expression level and inhibited p-Akt and p-mTOR expression levels, whereas 3-MA could partially reverse the biological effects of LTX-315 on OC cells.	3-methyladenine	111-115	AKT serine/threonine kinase 1	Homo sapiens	69-72
34294367-1	2021	We investigated the effect of 3-methyladenine (3MA), a class III phosphatidylinositol 3-kinase (PI3K)-blocking autophagy inhibitor, on cancer cell death induced by simultaneous inhibition of glycolysis by 2-deoxyglucose (2DG) and mitochondrial respiration by rotenone.	3-methyladenine	30-45	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	65-94
34294367-1	2021	We investigated the effect of 3-methyladenine (3MA), a class III phosphatidylinositol 3-kinase (PI3K)-blocking autophagy inhibitor, on cancer cell death induced by simultaneous inhibition of glycolysis by 2-deoxyglucose (2DG) and mitochondrial respiration by rotenone.	3-methyladenine	47-50	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	65-94
34294367-6	2021	3MA increased AMPK and mTORC1 activation in energy-stressed cells, but neither AMPK nor mTORC1 inhibition reduced its cytoprotective effect.	3-methyladenine	0-3	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	14-18
34294367-6	2021	3MA increased AMPK and mTORC1 activation in energy-stressed cells, but neither AMPK nor mTORC1 inhibition reduced its cytoprotective effect.	3-methyladenine	0-3	CREB regulated transcription coactivator 1	Mus musculus	23-29
34294367-7	2021	3MA reduced JNK activation, and JNK pharmacological/genetic suppression mimicked its mitochondria-preserving and cytoprotective activity.	3-methyladenine	0-3	mitogen-activated protein kinase 8	Homo sapiens	12-15
34294367-8	2021	Therefore, 3MA prevents energy stress-triggered cancer cell death through autophagy-independent mechanisms possibly involving JNK suppression and decrease of oxidative stress.	3-methyladenine	11-14	mitogen-activated protein kinase 8	Homo sapiens	126-129
34107107-6	2021	Once the autophagy was blocked by 3-methyladenine (3-MA) or knocking ATG5 down, the occurrence of FSS-induced EMT was inhibited dramatically according to the expression and translocation of E-cadherin, N-cadherin, and beta-catenin.	3-methyladenine	34-49	cadherin 1	Homo sapiens	190-200
34107107-6	2021	Once the autophagy was blocked by 3-methyladenine (3-MA) or knocking ATG5 down, the occurrence of FSS-induced EMT was inhibited dramatically according to the expression and translocation of E-cadherin, N-cadherin, and beta-catenin.	3-methyladenine	34-49	cadherin 2	Homo sapiens	202-212
34107107-6	2021	Once the autophagy was blocked by 3-methyladenine (3-MA) or knocking ATG5 down, the occurrence of FSS-induced EMT was inhibited dramatically according to the expression and translocation of E-cadherin, N-cadherin, and beta-catenin.	3-methyladenine	34-49	catenin beta 1	Homo sapiens	218-230
34107107-6	2021	Once the autophagy was blocked by 3-methyladenine (3-MA) or knocking ATG5 down, the occurrence of FSS-induced EMT was inhibited dramatically according to the expression and translocation of E-cadherin, N-cadherin, and beta-catenin.	3-methyladenine	51-55	cadherin 1	Homo sapiens	190-200
34107107-6	2021	Once the autophagy was blocked by 3-methyladenine (3-MA) or knocking ATG5 down, the occurrence of FSS-induced EMT was inhibited dramatically according to the expression and translocation of E-cadherin, N-cadherin, and beta-catenin.	3-methyladenine	51-55	cadherin 2	Homo sapiens	202-212
34107107-6	2021	Once the autophagy was blocked by 3-methyladenine (3-MA) or knocking ATG5 down, the occurrence of FSS-induced EMT was inhibited dramatically according to the expression and translocation of E-cadherin, N-cadherin, and beta-catenin.	3-methyladenine	51-55	catenin beta 1	Homo sapiens	218-230
34296312-10	2021	Moreover, DI induced cellular autophagy, whereas inhibition of autophagy with 3-methyladenine markedly reversed its inhibitory effect on NLRP3-dependent pyroptosis.	3-methyladenine	78-93	NLR family pyrin domain containing 3	Homo sapiens	137-142
34531846-4	2021	Biochemical data have demonstrated that 3-methyladenine DNA glycosylase II (AlkA) and Family V uracil DNA glycosylase (UDG) from HA could excise Hx from DNA, thus triggering a base excision repair (BER) process for Hx repair.	3-methyladenine	40-55	uracil DNA glycosylase	Homo sapiens	119-122
34484820-13	2021	The miR-149-induced protection against HUVECs injury could be reversed by cotreatment with 3-methyladenine (3-MA, an autophagy inhibitor) or insulin (an activator of Akt/mTOR pathway).	3-methyladenine	91-106	AKT serine/threonine kinase 1	Homo sapiens	166-169
34484820-13	2021	The miR-149-induced protection against HUVECs injury could be reversed by cotreatment with 3-methyladenine (3-MA, an autophagy inhibitor) or insulin (an activator of Akt/mTOR pathway).	3-methyladenine	91-106	mechanistic target of rapamycin kinase	Homo sapiens	170-174
34484820-13	2021	The miR-149-induced protection against HUVECs injury could be reversed by cotreatment with 3-methyladenine (3-MA, an autophagy inhibitor) or insulin (an activator of Akt/mTOR pathway).	3-methyladenine	108-112	mechanistic target of rapamycin kinase	Homo sapiens	170-174
34497522-7	2021	Blockade of autophagy with 3-MA effectively prevented PF in both models and reversed epithelial to mesenchymal transition (EMT) by down-regulating TGF-beta/Smad3 signaling pathway and downstream nuclear transcription factors Slug and Snail.	3-methyladenine	27-31	transforming growth factor alpha	Homo sapiens	147-155
34497522-7	2021	Blockade of autophagy with 3-MA effectively prevented PF in both models and reversed epithelial to mesenchymal transition (EMT) by down-regulating TGF-beta/Smad3 signaling pathway and downstream nuclear transcription factors Slug and Snail.	3-methyladenine	27-31	SMAD family member 3	Homo sapiens	156-161
34497522-7	2021	Blockade of autophagy with 3-MA effectively prevented PF in both models and reversed epithelial to mesenchymal transition (EMT) by down-regulating TGF-beta/Smad3 signaling pathway and downstream nuclear transcription factors Slug and Snail.	3-methyladenine	27-31	snail family transcriptional repressor 2	Homo sapiens	225-229
34497522-7	2021	Blockade of autophagy with 3-MA effectively prevented PF in both models and reversed epithelial to mesenchymal transition (EMT) by down-regulating TGF-beta/Smad3 signaling pathway and downstream nuclear transcription factors Slug and Snail.	3-methyladenine	27-31	snail family transcriptional repressor 1	Homo sapiens	234-239
34497522-8	2021	Treatment with 3-MA also inhibited activation of EGFR/ERK1/2 signaling pathway during PF.	3-methyladenine	15-19	epidermal growth factor receptor	Homo sapiens	49-53
34497522-8	2021	Treatment with 3-MA also inhibited activation of EGFR/ERK1/2 signaling pathway during PF.	3-methyladenine	15-19	mitogen-activated protein kinase 3	Homo sapiens	54-60
34497522-13	2021	In addition, delayed administration of 3-MA was effective in reducing EMT induced by TGF-beta1.	3-methyladenine	39-43	transforming growth factor beta 1	Homo sapiens	85-94
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	3-methyladenine	14-18	NLR family pyrin domain containing 3	Homo sapiens	45-50
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	3-methyladenine	14-18	caspase 1	Homo sapiens	52-61
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	3-methyladenine	14-18	NIMA related kinase 7	Homo sapiens	63-67
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	3-methyladenine	14-18	PYD and CARD domain containing	Homo sapiens	69-72
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	3-methyladenine	14-18	gasdermin A	Homo sapiens	74-79
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	3-methyladenine	14-18	interleukin 1 alpha	Homo sapiens	88-96
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	3-methyladenine	14-18	interleukin 18	Homo sapiens	98-103
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	3-methyladenine	14-18	NLR family pyrin domain containing 3	Homo sapiens	117-122
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	3-methyladenine	14-18	caspase 1	Homo sapiens	124-133
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	3-methyladenine	14-18	tubulin polymerization promoting protein family member 3	Homo sapiens	134-137
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	3-methyladenine	14-18	PYD and CARD domain containing	Homo sapiens	139-142
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	3-methyladenine	14-18	gasdermin D	Homo sapiens	144-149
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	3-methyladenine	14-18	interleukin 1 alpha	Homo sapiens	187-195
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	3-methyladenine	14-18	interleukin 18	Homo sapiens	197-202
34228649-6	2021	In vivo and in vitro, both 3-MA and Beclin-1 siRNAs inhibited autophagy and abolished ALDH2 mediated renoprotection.	3-methyladenine	27-31	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	86-91
34314052-9	2021	Inhibition of autophagy by 3-methyladenine or Atg5 gene knockdown attenuated recovery of AQP1 protein expression induced by TDZD-8 in IMCD3 cells with H/R.	3-methyladenine	27-42	aquaporin 1	Mus musculus	89-93
34105058-8	2021	In addition, CGP significantly attenuated LPS-induced oxidative injury, and improved Cav-3 expression and eNOS activation, similar effects were shown by the treatment of autophagy inhibitor 3-MA.	3-methyladenine	190-194	caveolin 3	Homo sapiens	85-90
34105058-8	2021	In addition, CGP significantly attenuated LPS-induced oxidative injury, and improved Cav-3 expression and eNOS activation, similar effects were shown by the treatment of autophagy inhibitor 3-MA.	3-methyladenine	190-194	nitric oxide synthase 3	Homo sapiens	106-110
34132358-10	2021	Moreover, autophagy inhibitor 3-methyladenine treatment inhibited cell autophagy and apoptosis in miR-16-5p-overexpressing cells.	3-methyladenine	30-45	glycerophosphodiester phosphodiesterase 1	Homo sapiens	98-104
34143206-5	2021	Importantly, both of autophagic activity (LC3 conversion rate and LC3 puncta formation) and total death level promoted by DUSP4 silencing were reversed by treatment with 3-MA in CCRCC cells.	3-methyladenine	170-174	dual specificity phosphatase 4	Homo sapiens	122-127
34143206-6	2021	Moreover, the proliferation and migration of CCRCC cells inhibited by DUSP4 silencing were also recovered by suppression of autophagy with 3-MA.	3-methyladenine	139-143	dual specificity phosphatase 4	Homo sapiens	70-75
34440619-8	2021	The autophagy inhibitor 3-MA partially reduced the neuroprotective effect of Nrf2 through the inhibition of the autophagy pathway, but not the antioxidant signaling pathway.	3-methyladenine	24-28	Keap1	Drosophila melanogaster	77-81
34305405-9	2021	However, 3-MA inhibited the combination of Beclin-1 and PI3KC3 and weakened the fibroblasts" proliferation, migration, conversion, and collagen synthesis activities.	3-methyladenine	9-13	beclin 1	Homo sapiens	43-51
34299093-5	2021	It was found that chloroquine, NH4Cl and 3MA markedly increased tau accumulation.	3-methyladenine	41-44	microtubule associated protein tau	Homo sapiens	64-67
34356312-8	2021	Interestingly, using autophagy inhibitors such as 3-methyladenine (3-MA) and chloroquine (CQ) both showed an increase in cleaved-PARP protein level, indicating apoptosis induction.	3-methyladenine	50-65	poly(ADP-ribose) polymerase 1	Homo sapiens	129-133
34356312-8	2021	Interestingly, using autophagy inhibitors such as 3-methyladenine (3-MA) and chloroquine (CQ) both showed an increase in cleaved-PARP protein level, indicating apoptosis induction.	3-methyladenine	67-71	poly(ADP-ribose) polymerase 1	Homo sapiens	129-133
34213019-9	2022	The autophagy inhibitor 3-methyladenine (3MA) significantly abrogated the LPS-sustained inflammatory effect by reducing the expression of IL-6, TNF-alpha, COX-2, and ICAM-1 in HGFs.	3-methyladenine	24-39	interleukin 6	Homo sapiens	138-142
34213019-9	2022	The autophagy inhibitor 3-methyladenine (3MA) significantly abrogated the LPS-sustained inflammatory effect by reducing the expression of IL-6, TNF-alpha, COX-2, and ICAM-1 in HGFs.	3-methyladenine	24-39	tumor necrosis factor	Homo sapiens	144-153
34213019-9	2022	The autophagy inhibitor 3-methyladenine (3MA) significantly abrogated the LPS-sustained inflammatory effect by reducing the expression of IL-6, TNF-alpha, COX-2, and ICAM-1 in HGFs.	3-methyladenine	24-39	prostaglandin-endoperoxide synthase 2	Homo sapiens	155-160
34213019-9	2022	The autophagy inhibitor 3-methyladenine (3MA) significantly abrogated the LPS-sustained inflammatory effect by reducing the expression of IL-6, TNF-alpha, COX-2, and ICAM-1 in HGFs.	3-methyladenine	24-39	intercellular adhesion molecule 1	Homo sapiens	166-172
34213019-9	2022	The autophagy inhibitor 3-methyladenine (3MA) significantly abrogated the LPS-sustained inflammatory effect by reducing the expression of IL-6, TNF-alpha, COX-2, and ICAM-1 in HGFs.	3-methyladenine	41-44	interleukin 6	Homo sapiens	138-142
34213019-9	2022	The autophagy inhibitor 3-methyladenine (3MA) significantly abrogated the LPS-sustained inflammatory effect by reducing the expression of IL-6, TNF-alpha, COX-2, and ICAM-1 in HGFs.	3-methyladenine	41-44	tumor necrosis factor	Homo sapiens	144-153
34213019-9	2022	The autophagy inhibitor 3-methyladenine (3MA) significantly abrogated the LPS-sustained inflammatory effect by reducing the expression of IL-6, TNF-alpha, COX-2, and ICAM-1 in HGFs.	3-methyladenine	41-44	prostaglandin-endoperoxide synthase 2	Homo sapiens	155-160
34213019-9	2022	The autophagy inhibitor 3-methyladenine (3MA) significantly abrogated the LPS-sustained inflammatory effect by reducing the expression of IL-6, TNF-alpha, COX-2, and ICAM-1 in HGFs.	3-methyladenine	41-44	intercellular adhesion molecule 1	Homo sapiens	166-172
34422996-7	2021	After the cells had been treated with or without 20 muM oridonin and 10 muM 3-MA, the formation of GFP-LC3 puncta was detected by fluorescence microscopy.	3-methyladenine	76-80	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	103-106
34249726-5	2021	Besides, when treatment with sorafenib, inhibition of apoptosis using the pan-caspase inhibitor Z-VAD-FMK and inhibition of autophagy using autophagy inhibitor 3-Methyladenine (3-MA) or small interfering RNA (siRNA) of LC3B all significantly reversed CASK knockout-induced effects, suggesting that both apoptosis and autophagy were involved in CASK-mediated above functions and autophagy played a pro-death role in this research.	3-methyladenine	160-175	calcium/calmodulin dependent serine protein kinase	Homo sapiens	251-255
34249726-5	2021	Besides, when treatment with sorafenib, inhibition of apoptosis using the pan-caspase inhibitor Z-VAD-FMK and inhibition of autophagy using autophagy inhibitor 3-Methyladenine (3-MA) or small interfering RNA (siRNA) of LC3B all significantly reversed CASK knockout-induced effects, suggesting that both apoptosis and autophagy were involved in CASK-mediated above functions and autophagy played a pro-death role in this research.	3-methyladenine	160-175	calcium/calmodulin dependent serine protein kinase	Homo sapiens	344-348
34249726-5	2021	Besides, when treatment with sorafenib, inhibition of apoptosis using the pan-caspase inhibitor Z-VAD-FMK and inhibition of autophagy using autophagy inhibitor 3-Methyladenine (3-MA) or small interfering RNA (siRNA) of LC3B all significantly reversed CASK knockout-induced effects, suggesting that both apoptosis and autophagy were involved in CASK-mediated above functions and autophagy played a pro-death role in this research.	3-methyladenine	177-181	calcium/calmodulin dependent serine protein kinase	Homo sapiens	251-255
34249726-5	2021	Besides, when treatment with sorafenib, inhibition of apoptosis using the pan-caspase inhibitor Z-VAD-FMK and inhibition of autophagy using autophagy inhibitor 3-Methyladenine (3-MA) or small interfering RNA (siRNA) of LC3B all significantly reversed CASK knockout-induced effects, suggesting that both apoptosis and autophagy were involved in CASK-mediated above functions and autophagy played a pro-death role in this research.	3-methyladenine	177-181	calcium/calmodulin dependent serine protein kinase	Homo sapiens	344-348
34257705-9	2021	Modulation of autophagy using autophagy inhibitor 3-methyladenine (3-MA) could abrogate GB-downregulated transcription of NPPA.	3-methyladenine	50-65	natriuretic peptide A	Rattus norvegicus	122-126
34257705-9	2021	Modulation of autophagy using autophagy inhibitor 3-methyladenine (3-MA) could abrogate GB-downregulated transcription of NPPA.	3-methyladenine	67-71	natriuretic peptide A	Rattus norvegicus	122-126
34221236-10	2021	Rapamycin attenuated oxLDL/beta2GPI/anti-beta2GPI complex-induced endothelial inflammation, oxidative stress, and apoptosis, whereas 3-MA alone induced the endothelial injury.	3-methyladenine	133-137	apolipoprotein H	Homo sapiens	27-35
34122092-15	2021	Furthermore, 3-methyladenine and small interfering RNA against Atg7 could reverse the protective effect of KD on LO2 cells.	3-methyladenine	13-28	autophagy related 7	Homo sapiens	63-67
34122411-4	2021	Here we demonstrate that inhibition of autophagy by treatment with 3-methyladenine (3-MA) or by silencing autophagy-related (ATG)5 promoted interleukin (IL)-6-dependent EndMT in human umbilical vein endothelial cells (HUVECs) and human renal glomerular endothelial cells (HRGECs), and autophagy inactivation was associated with EndMT in patients with chronic allograft dysfunction.	3-methyladenine	67-82	interleukin 6	Homo sapiens	140-158
34122411-4	2021	Here we demonstrate that inhibition of autophagy by treatment with 3-methyladenine (3-MA) or by silencing autophagy-related (ATG)5 promoted interleukin (IL)-6-dependent EndMT in human umbilical vein endothelial cells (HUVECs) and human renal glomerular endothelial cells (HRGECs), and autophagy inactivation was associated with EndMT in patients with chronic allograft dysfunction.	3-methyladenine	84-88	interleukin 6	Homo sapiens	140-158
34122411-5	2021	IL-6 level was significantly higher in the culture medium of HUVECs transfected with ATG5 siRNA or treated with 3-MA compared to the respective control groups.	3-methyladenine	112-116	interleukin 6	Homo sapiens	0-4
34137231-9	2021	After treatment with the autophagy inhibitor 3-MA, the expression levels of LC3, NFATc1, TRAF6, p-ERK, and p-p38 all decreased significantly (all 0.05).	3-methyladenine	45-49	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	76-79
34137231-9	2021	After treatment with the autophagy inhibitor 3-MA, the expression levels of LC3, NFATc1, TRAF6, p-ERK, and p-p38 all decreased significantly (all 0.05).	3-methyladenine	45-49	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	81-87
34137231-9	2021	After treatment with the autophagy inhibitor 3-MA, the expression levels of LC3, NFATc1, TRAF6, p-ERK, and p-p38 all decreased significantly (all 0.05).	3-methyladenine	45-49	TNF receptor-associated factor 6	Mus musculus	89-94
34137231-9	2021	After treatment with the autophagy inhibitor 3-MA, the expression levels of LC3, NFATc1, TRAF6, p-ERK, and p-p38 all decreased significantly (all 0.05).	3-methyladenine	45-49	mitogen-activated protein kinase 1	Mus musculus	98-101
34137231-9	2021	After treatment with the autophagy inhibitor 3-MA, the expression levels of LC3, NFATc1, TRAF6, p-ERK, and p-p38 all decreased significantly (all 0.05).	3-methyladenine	45-49	mitogen-activated protein kinase 14	Mus musculus	109-112
34775933-10	2021	Meanwhile, we found that treatment of 3-MA (autophagy inhibitor) could enhance the protective effects of Ginsenoside Rb1 on H9C2 cells during H/R.	3-methyladenine	38-42	RB transcriptional corepressor 1	Rattus norvegicus	117-120
34109916-12	2021	The Annexin V FITC/PI assay also revealed that in comparison to the pseudo-G-Rh2 group, the concurrent treatment with pseudo-G-Rh2 and an autophagy inhibitor (CQ or 3-MA) significantly induced distinct apoptosis.	3-methyladenine	165-169	annexin A5	Homo sapiens	4-13
35447319-8	2022	Furthermore, 3-MA causes lower Beclin-1, higher mTOR and p62 on both gene and protein levels, while the expression of t-tau, p-tau, GSK-3beta and CDK5 are upregulated, demonstrating that impaired autophagy disturbs the clearance of tau.	3-methyladenine	13-17	beclin 1, autophagy related	Mus musculus	31-39
35447319-8	2022	Furthermore, 3-MA causes lower Beclin-1, higher mTOR and p62 on both gene and protein levels, while the expression of t-tau, p-tau, GSK-3beta and CDK5 are upregulated, demonstrating that impaired autophagy disturbs the clearance of tau.	3-methyladenine	13-17	mechanistic target of rapamycin kinase	Mus musculus	48-52
35447319-8	2022	Furthermore, 3-MA causes lower Beclin-1, higher mTOR and p62 on both gene and protein levels, while the expression of t-tau, p-tau, GSK-3beta and CDK5 are upregulated, demonstrating that impaired autophagy disturbs the clearance of tau.	3-methyladenine	13-17	nucleoporin 62	Mus musculus	57-60
35447319-8	2022	Furthermore, 3-MA causes lower Beclin-1, higher mTOR and p62 on both gene and protein levels, while the expression of t-tau, p-tau, GSK-3beta and CDK5 are upregulated, demonstrating that impaired autophagy disturbs the clearance of tau.	3-methyladenine	13-17	glycogen synthase kinase 3 alpha	Mus musculus	132-141
35447319-8	2022	Furthermore, 3-MA causes lower Beclin-1, higher mTOR and p62 on both gene and protein levels, while the expression of t-tau, p-tau, GSK-3beta and CDK5 are upregulated, demonstrating that impaired autophagy disturbs the clearance of tau.	3-methyladenine	13-17	cyclin-dependent kinase 5	Mus musculus	146-150
35636015-14	2022	Treatment with N-Acetylcysteine (NAC), a ROS scavenger or the autophagy inhibitor 3-Methyladenine (3-MA) abolished the decreased malignant phenotypes in TRIM22 overexpressing OS cells.	3-methyladenine	82-97	tripartite motif containing 22	Homo sapiens	153-159
35636015-14	2022	Treatment with N-Acetylcysteine (NAC), a ROS scavenger or the autophagy inhibitor 3-Methyladenine (3-MA) abolished the decreased malignant phenotypes in TRIM22 overexpressing OS cells.	3-methyladenine	99-103	tripartite motif containing 22	Homo sapiens	153-159
35331835-9	2022	Moreover, we observed that TRIM25-mediated XRCC5 degradation was reversed by proteasome inhibitor MG-132 or lysosome inhibitor 3-MA.	3-methyladenine	127-131	tripartite motif containing 25	Homo sapiens	27-33
35331835-9	2022	Moreover, we observed that TRIM25-mediated XRCC5 degradation was reversed by proteasome inhibitor MG-132 or lysosome inhibitor 3-MA.	3-methyladenine	127-131	X-ray repair cross complementing 5	Homo sapiens	43-48
35341775-12	2022	Treatment with the autophagy inhibitor 3-methyladenine (3-MA) attenuated the effect of metformin on apoptosis, autophagy, and the AMPK/mTOR/p70S6K signaling pathway.	3-methyladenine	39-54	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	130-134
35341775-12	2022	Treatment with the autophagy inhibitor 3-methyladenine (3-MA) attenuated the effect of metformin on apoptosis, autophagy, and the AMPK/mTOR/p70S6K signaling pathway.	3-methyladenine	39-54	mechanistic target of rapamycin kinase	Homo sapiens	135-139
35341775-12	2022	Treatment with the autophagy inhibitor 3-methyladenine (3-MA) attenuated the effect of metformin on apoptosis, autophagy, and the AMPK/mTOR/p70S6K signaling pathway.	3-methyladenine	39-54	ribosomal protein S6 kinase B1	Homo sapiens	140-146
35341775-12	2022	Treatment with the autophagy inhibitor 3-methyladenine (3-MA) attenuated the effect of metformin on apoptosis, autophagy, and the AMPK/mTOR/p70S6K signaling pathway.	3-methyladenine	56-60	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	130-134
35341775-12	2022	Treatment with the autophagy inhibitor 3-methyladenine (3-MA) attenuated the effect of metformin on apoptosis, autophagy, and the AMPK/mTOR/p70S6K signaling pathway.	3-methyladenine	56-60	mechanistic target of rapamycin kinase	Homo sapiens	135-139
35341775-12	2022	Treatment with the autophagy inhibitor 3-methyladenine (3-MA) attenuated the effect of metformin on apoptosis, autophagy, and the AMPK/mTOR/p70S6K signaling pathway.	3-methyladenine	56-60	ribosomal protein S6 kinase B1	Homo sapiens	140-146
35609863-11	2022	Autophagy inhibitor 3-methyladenine significantly attenuated autophagy activation and disturbed the effect of the inducers on Abeta load.	3-methyladenine	20-35	amyloid beta (A4) precursor protein	Mus musculus	126-131
35612957-7	2022	Furthermore, the role of ERbeta in BGC autophagy was confirmed through treatment with rapamycin (RAPA) or 3-methyladenine (3-MA) in BGCs by cotransfection with si-ERbeta or oe-ERbeta in BGCs.	3-methyladenine	106-121	estrogen receptor 2	Bos taurus	25-31
35612957-7	2022	Furthermore, the role of ERbeta in BGC autophagy was confirmed through treatment with rapamycin (RAPA) or 3-methyladenine (3-MA) in BGCs by cotransfection with si-ERbeta or oe-ERbeta in BGCs.	3-methyladenine	106-121	estrogen receptor 2	Bos taurus	176-182
35612957-7	2022	Furthermore, the role of ERbeta in BGC autophagy was confirmed through treatment with rapamycin (RAPA) or 3-methyladenine (3-MA) in BGCs by cotransfection with si-ERbeta or oe-ERbeta in BGCs.	3-methyladenine	123-127	estrogen receptor 2	Bos taurus	25-31
35612957-7	2022	Furthermore, the role of ERbeta in BGC autophagy was confirmed through treatment with rapamycin (RAPA) or 3-methyladenine (3-MA) in BGCs by cotransfection with si-ERbeta or oe-ERbeta in BGCs.	3-methyladenine	123-127	estrogen receptor 2	Bos taurus	176-182
35628508-7	2022	RAPA treatment (an inducer of autophagy) significantly improved realgar-induced liver injury and NLRP3 inflammasome activation, while 3-MA (an inhibitor of autophagy) aggravated the realgar-induced liver injury and NLRP3 inflammasome activation.	3-methyladenine	134-138	NLR family, pyrin domain containing 3	Mus musculus	97-102
35628508-7	2022	RAPA treatment (an inducer of autophagy) significantly improved realgar-induced liver injury and NLRP3 inflammasome activation, while 3-MA (an inhibitor of autophagy) aggravated the realgar-induced liver injury and NLRP3 inflammasome activation.	3-methyladenine	134-138	NLR family, pyrin domain containing 3	Mus musculus	215-220
35506243-6	2022	These findings suggest that MAPS safeguards microautophagy to avoid DNAJC5-associated lipofuscinosis and neurodegeneration.Abbreviations: 3-MA: 3-methyladenine; ACTB: actin beta; AFSM: autofluorescent storage materials; ANCL: adult neuronal ceroid lipofuscinosis; Baf.	3-methyladenine	144-159	Cysteine string protein	Drosophila melanogaster	68-74
35378205-7	2022	Inhibition of autophagy or Akt pathways by chloroquine (CQ), 3-Methyladenine (3-MA) or LY294002 promoted colistin-induced mitochondrial damage, and caspase-dependent cellular apoptosis.	3-methyladenine	61-76	thymoma viral proto-oncogene 1	Mus musculus	27-30
35378205-7	2022	Inhibition of autophagy or Akt pathways by chloroquine (CQ), 3-Methyladenine (3-MA) or LY294002 promoted colistin-induced mitochondrial damage, and caspase-dependent cellular apoptosis.	3-methyladenine	78-82	thymoma viral proto-oncogene 1	Mus musculus	27-30
35438806-8	2022	Mechanistically, poly(I:C) activated the PI3K/AKT/mTOR pathway to induce autophagy, which was abolished by LY294002 (PI3K antagonist), rapamycin (autophagy activator and mTOR inhibitor), or 3-methyladenine (autophagy inhibitor), suggesting either inhibition of the PI3K/Akt/mTOR pathway or autophagy activity interrupt the beneficial effect of poly(I:C) preconditioning.	3-methyladenine	190-205	AKT serine/threonine kinase 1	Rattus norvegicus	46-49
35438806-8	2022	Mechanistically, poly(I:C) activated the PI3K/AKT/mTOR pathway to induce autophagy, which was abolished by LY294002 (PI3K antagonist), rapamycin (autophagy activator and mTOR inhibitor), or 3-methyladenine (autophagy inhibitor), suggesting either inhibition of the PI3K/Akt/mTOR pathway or autophagy activity interrupt the beneficial effect of poly(I:C) preconditioning.	3-methyladenine	190-205	mechanistic target of rapamycin kinase	Rattus norvegicus	50-54
35158226-12	2022	Adoptive transfer of OVA-loaded BMDCs could promote the allergic inflammation, while the administration of 3-MA on OVA-loaded BMDCs could significantly reduce the AR inflammation.	3-methyladenine	107-111	ferredoxin reductase	Mus musculus	163-165
35190953-9	2022	In addition, 3-methyladenine (3-MA), an inhibitor of the PI3K/AKT signaling pathway, significantly inhibits the increase in autophagy levels, aggravates HI-induced apoptosis, and reverses the neuroprotective effect of macamide B on HIBD.	3-methyladenine	13-28	thymoma viral proto-oncogene 1	Mus musculus	62-65
35190953-9	2022	In addition, 3-methyladenine (3-MA), an inhibitor of the PI3K/AKT signaling pathway, significantly inhibits the increase in autophagy levels, aggravates HI-induced apoptosis, and reverses the neuroprotective effect of macamide B on HIBD.	3-methyladenine	30-34	thymoma viral proto-oncogene 1	Mus musculus	62-65
35563682-5	2022	Following preconditioning, both Rapa and 3-MA-treated hASCs demonstrated preservation of stemness, as well as upregulated transcription of cyclooxygenase-2 (COX2) and interleukin-6 (IL-6).	3-methyladenine	41-45	prostaglandin-endoperoxide synthase 2	Homo sapiens	139-155
35563682-5	2022	Following preconditioning, both Rapa and 3-MA-treated hASCs demonstrated preservation of stemness, as well as upregulated transcription of cyclooxygenase-2 (COX2) and interleukin-6 (IL-6).	3-methyladenine	41-45	prostaglandin-endoperoxide synthase 2	Homo sapiens	157-161
35563682-5	2022	Following preconditioning, both Rapa and 3-MA-treated hASCs demonstrated preservation of stemness, as well as upregulated transcription of cyclooxygenase-2 (COX2) and interleukin-6 (IL-6).	3-methyladenine	41-45	interleukin 6	Homo sapiens	167-180
35563682-5	2022	Following preconditioning, both Rapa and 3-MA-treated hASCs demonstrated preservation of stemness, as well as upregulated transcription of cyclooxygenase-2 (COX2) and interleukin-6 (IL-6).	3-methyladenine	41-45	interleukin 6	Homo sapiens	182-186
35468684-7	2022	Besides, the drug also enhanced cell autophagy and apoptosis of MCF-7 and MDA-MB-231 cell lines, which could be rescued by autophagy inhibitors wortmannin (wort) and 3-methyladenine (3-MA), and BECN1 knockdown.	3-methyladenine	166-181	beclin 1	Homo sapiens	194-199
35468684-7	2022	Besides, the drug also enhanced cell autophagy and apoptosis of MCF-7 and MDA-MB-231 cell lines, which could be rescued by autophagy inhibitors wortmannin (wort) and 3-methyladenine (3-MA), and BECN1 knockdown.	3-methyladenine	183-187	beclin 1	Homo sapiens	194-199
35468684-8	2022	Furthermore, Akt/GSK-3alpha pathway was inactivated by anlotinib treatment, while rescued by wort, 3-MA and silencing of BECN1 in the MCF-7 or MDA-MB-231 cells.	3-methyladenine	99-103	AKT serine/threonine kinase 1	Homo sapiens	13-16
35468684-8	2022	Furthermore, Akt/GSK-3alpha pathway was inactivated by anlotinib treatment, while rescued by wort, 3-MA and silencing of BECN1 in the MCF-7 or MDA-MB-231 cells.	3-methyladenine	99-103	glycogen synthase kinase 3 alpha	Homo sapiens	17-27
35383175-8	2022	An inhibitor of autophagy, 3-MA, and an inhibitor of NF-kB, JSH-23, attenuated the function of NOP in HCC.	3-methyladenine	27-31	opioid related nociceptin receptor 1	Homo sapiens	95-98
35228068-0	2022	PI3K inhibitor 3-MA promotes the antiproliferative activity of esomeprazole in gastric cancer cells by downregulating EGFR via the PI3K/FOXO3a pathway.	3-methyladenine	15-19	epidermal growth factor receptor	Homo sapiens	118-122
35228068-0	2022	PI3K inhibitor 3-MA promotes the antiproliferative activity of esomeprazole in gastric cancer cells by downregulating EGFR via the PI3K/FOXO3a pathway.	3-methyladenine	15-19	forkhead box O3	Homo sapiens	136-142
35228068-10	2022	3-MA enhanced the antiproliferative activity of ESO and synergistically inhibited PI3K/FOXO3a signaling and the expression of EGFR but not SKP2.	3-methyladenine	0-4	forkhead box O3	Homo sapiens	87-93
35228068-10	2022	3-MA enhanced the antiproliferative activity of ESO and synergistically inhibited PI3K/FOXO3a signaling and the expression of EGFR but not SKP2.	3-methyladenine	0-4	epidermal growth factor receptor	Homo sapiens	126-130
35228068-12	2022	In conclusion, our results suggested that the PI3K inhibitor 3-MA promotes the antiproliferative activity of ESO in gastric cancer cells by synergistically downregulating EGFR via the PI3K/FOXO3a pathway.	3-methyladenine	61-65	epidermal growth factor receptor	Homo sapiens	171-175
35228068-12	2022	In conclusion, our results suggested that the PI3K inhibitor 3-MA promotes the antiproliferative activity of ESO in gastric cancer cells by synergistically downregulating EGFR via the PI3K/FOXO3a pathway.	3-methyladenine	61-65	forkhead box O3	Homo sapiens	189-195
35179253-11	2022	Furthermore, after autophagy inhibitor 3-methyladenine administration, silencing of IGF2BP1-reduced lipid accumulation and inflammation were recovered in RAW264.7 cells.	3-methyladenine	39-54	insulin-like growth factor 2 mRNA binding protein 1	Mus musculus	84-91
34984683-15	2022	AdipoAI and AdipoRon also enhanced LC3A/B expression when cultured with RANKL.3-Methyladenine, a known autophagy inhibitor, decreased LC3A/B expression and reversed the inhibition of osteoclastogenesis during AdipoAI treatment.	3-methyladenine	78-93	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	35-41
34984683-15	2022	AdipoAI and AdipoRon also enhanced LC3A/B expression when cultured with RANKL.3-Methyladenine, a known autophagy inhibitor, decreased LC3A/B expression and reversed the inhibition of osteoclastogenesis during AdipoAI treatment.	3-methyladenine	78-93	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	72-77
34984683-15	2022	AdipoAI and AdipoRon also enhanced LC3A/B expression when cultured with RANKL.3-Methyladenine, a known autophagy inhibitor, decreased LC3A/B expression and reversed the inhibition of osteoclastogenesis during AdipoAI treatment.	3-methyladenine	78-93	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	134-140
35583062-8	2022	In addition, the autophagy inhibitor 3-MA down-regulated the expression of alpha-SMA, elevated the expression of E-cadherin, and significantly alleviated the ROS level.	3-methyladenine	37-41	actin alpha 1, skeletal muscle	Homo sapiens	75-84
35583062-8	2022	In addition, the autophagy inhibitor 3-MA down-regulated the expression of alpha-SMA, elevated the expression of E-cadherin, and significantly alleviated the ROS level.	3-methyladenine	37-41	cadherin 1	Homo sapiens	113-123
35354793-10	2022	Adding the autophagy inhibitor 3-methyladenine or chloroquine attenuated the inhibitory effect of Irisin on beta-GP-induced ROS production, NLRP3 inflammasome activation, pyroptosis, and calcification in VSMCs.	3-methyladenine	31-46	NLR family, pyrin domain containing 3	Mus musculus	140-145
35175747-9	2022	Further, the autophagy activator rapamycin (Rap) and the inhibitor 3-methylademine (3-MA) were introduced, which showed that the apoptosis rate and the ratio of Bax/Bcl-2 as well as the protein expression level of cleaved caspase-3 increased significantly with the pretreatment of Rap and decreased remarkably with the pretreatment of 3-MA.	3-methyladenine	84-88	BCL2-associated X protein	Mus musculus	161-164
35175747-9	2022	Further, the autophagy activator rapamycin (Rap) and the inhibitor 3-methylademine (3-MA) were introduced, which showed that the apoptosis rate and the ratio of Bax/Bcl-2 as well as the protein expression level of cleaved caspase-3 increased significantly with the pretreatment of Rap and decreased remarkably with the pretreatment of 3-MA.	3-methyladenine	84-88	B cell leukemia/lymphoma 2	Mus musculus	165-170
35175747-9	2022	Further, the autophagy activator rapamycin (Rap) and the inhibitor 3-methylademine (3-MA) were introduced, which showed that the apoptosis rate and the ratio of Bax/Bcl-2 as well as the protein expression level of cleaved caspase-3 increased significantly with the pretreatment of Rap and decreased remarkably with the pretreatment of 3-MA.	3-methyladenine	84-88	caspase 3	Mus musculus	222-231
35175747-9	2022	Further, the autophagy activator rapamycin (Rap) and the inhibitor 3-methylademine (3-MA) were introduced, which showed that the apoptosis rate and the ratio of Bax/Bcl-2 as well as the protein expression level of cleaved caspase-3 increased significantly with the pretreatment of Rap and decreased remarkably with the pretreatment of 3-MA.	3-methyladenine	84-88	regulatory associated protein of MTOR, complex 1	Mus musculus	281-284
35175747-9	2022	Further, the autophagy activator rapamycin (Rap) and the inhibitor 3-methylademine (3-MA) were introduced, which showed that the apoptosis rate and the ratio of Bax/Bcl-2 as well as the protein expression level of cleaved caspase-3 increased significantly with the pretreatment of Rap and decreased remarkably with the pretreatment of 3-MA.	3-methyladenine	335-339	regulatory associated protein of MTOR, complex 1	Mus musculus	33-42
35175747-9	2022	Further, the autophagy activator rapamycin (Rap) and the inhibitor 3-methylademine (3-MA) were introduced, which showed that the apoptosis rate and the ratio of Bax/Bcl-2 as well as the protein expression level of cleaved caspase-3 increased significantly with the pretreatment of Rap and decreased remarkably with the pretreatment of 3-MA.	3-methyladenine	335-339	regulatory associated protein of MTOR, complex 1	Mus musculus	44-47
35278160-4	2022	Co-application of 3-methyladenine and metformin partially inhibited the effect of metformin in recovering Beclin-1 expression and in reducing the pain behavior in rats subjected to BTZ treatment.	3-methyladenine	18-33	beclin 1	Rattus norvegicus	106-114
35308165-8	2022	Inhibition of autophagy by 3-methyladenine (3-MA) partially reversed the antisenescence and antiapoptotic effects of BRD4.	3-methyladenine	44-48	bromodomain containing 4	Homo sapiens	117-121
35309342-6	2022	Inhibition of autophagy with 3-methyladenine (3-MA) and transfected with Beclin-1 siRNA prevented uric acid-induced upregulation of alpha-SMA, Collagen I and Collagen III in HK-2 cells.	3-methyladenine	29-44	actin alpha 1, skeletal muscle	Homo sapiens	132-141
35309342-6	2022	Inhibition of autophagy with 3-methyladenine (3-MA) and transfected with Beclin-1 siRNA prevented uric acid-induced upregulation of alpha-SMA, Collagen I and Collagen III in HK-2 cells.	3-methyladenine	46-50	actin alpha 1, skeletal muscle	Homo sapiens	132-141
35309342-10	2022	Stimulation with uric acid in HK-2 cells also resulted in NLRP3 inflammasome activation and pyroptotic cell death, however treatment with 3-MA prevented all these responses.	3-methyladenine	138-142	NLR family pyrin domain containing 3	Homo sapiens	58-63
35235244-9	2022	Rapamycin treatment resulted in significant increase in Beclin-1 and LC3-II levels and further aggravation of alveolar tissue damage, while 3-MA treatment led to opposite effects.	3-methyladenine	140-144	annexin A3	Rattus norvegicus	69-72
35433984-14	2022	Notably, 3-methyladenine, a PI3K inhibitor, reversed the effects of acteoside and Cav1 overexpression on RGC loss, oxidative stress, and autophagy.	3-methyladenine	9-24	caveolin 1	Homo sapiens	82-86
35106915-10	2022	The cleavage of the apoptosis-related markers caspase-3 and caspase-9 and the activity of caspase-3 induced by ASK were markedly reduced by inhibitor of AMPK (compound C), an autophagy inhibitor 3-methyladenine (3-MA) and another autophagy inhibitor chloroquine (CQ).	3-methyladenine	195-210	caspase 3	Homo sapiens	46-55
35106915-10	2022	The cleavage of the apoptosis-related markers caspase-3 and caspase-9 and the activity of caspase-3 induced by ASK were markedly reduced by inhibitor of AMPK (compound C), an autophagy inhibitor 3-methyladenine (3-MA) and another autophagy inhibitor chloroquine (CQ).	3-methyladenine	195-210	caspase 9	Homo sapiens	60-69
35106915-10	2022	The cleavage of the apoptosis-related markers caspase-3 and caspase-9 and the activity of caspase-3 induced by ASK were markedly reduced by inhibitor of AMPK (compound C), an autophagy inhibitor 3-methyladenine (3-MA) and another autophagy inhibitor chloroquine (CQ).	3-methyladenine	195-210	caspase 3	Homo sapiens	90-99
35106915-10	2022	The cleavage of the apoptosis-related markers caspase-3 and caspase-9 and the activity of caspase-3 induced by ASK were markedly reduced by inhibitor of AMPK (compound C), an autophagy inhibitor 3-methyladenine (3-MA) and another autophagy inhibitor chloroquine (CQ).	3-methyladenine	212-216	caspase 3	Homo sapiens	90-99
35088889-9	2022	While 4-hydroxytamoxifen (4-OHT) increased ATG4A expression in MCF7 and MCF7/R cells, ATG4A expression decreased in the cells treated with 3-methyladenine (3MA).	3-methyladenine	139-154	autophagy related 4A cysteine peptidase	Homo sapiens	86-91
35088889-9	2022	While 4-hydroxytamoxifen (4-OHT) increased ATG4A expression in MCF7 and MCF7/R cells, ATG4A expression decreased in the cells treated with 3-methyladenine (3MA).	3-methyladenine	156-159	autophagy related 4A cysteine peptidase	Homo sapiens	86-91
35226448-10	2022	Moreover, tetrazole and 3-MA combination increased cleavage of caspase-3 to a greater extent compared to tetrazole.	3-methyladenine	24-28	caspase 3	Homo sapiens	63-72
35365454-5	2022	The effects of melatonin treatment alone or in combination with 3-methyladenine (3-MA) on the expressions of the proteins associated with autophagy (LC3, P62 and Beclin1), apoptosis (Bcl2 and Bax) and epithelial-mesenchymal transition (E-cadherin and Snail) were examined with Western blotting.	3-methyladenine	64-79	nucleoporin 62	Homo sapiens	154-157
35365454-5	2022	The effects of melatonin treatment alone or in combination with 3-methyladenine (3-MA) on the expressions of the proteins associated with autophagy (LC3, P62 and Beclin1), apoptosis (Bcl2 and Bax) and epithelial-mesenchymal transition (E-cadherin and Snail) were examined with Western blotting.	3-methyladenine	64-79	beclin 1	Homo sapiens	162-169
35365454-5	2022	The effects of melatonin treatment alone or in combination with 3-methyladenine (3-MA) on the expressions of the proteins associated with autophagy (LC3, P62 and Beclin1), apoptosis (Bcl2 and Bax) and epithelial-mesenchymal transition (E-cadherin and Snail) were examined with Western blotting.	3-methyladenine	64-79	BCL2 apoptosis regulator	Homo sapiens	183-187
35365454-5	2022	The effects of melatonin treatment alone or in combination with 3-methyladenine (3-MA) on the expressions of the proteins associated with autophagy (LC3, P62 and Beclin1), apoptosis (Bcl2 and Bax) and epithelial-mesenchymal transition (E-cadherin and Snail) were examined with Western blotting.	3-methyladenine	64-79	BCL2 associated X, apoptosis regulator	Homo sapiens	192-195
35365454-5	2022	The effects of melatonin treatment alone or in combination with 3-methyladenine (3-MA) on the expressions of the proteins associated with autophagy (LC3, P62 and Beclin1), apoptosis (Bcl2 and Bax) and epithelial-mesenchymal transition (E-cadherin and Snail) were examined with Western blotting.	3-methyladenine	64-79	cadherin 1	Homo sapiens	236-246
35365454-5	2022	The effects of melatonin treatment alone or in combination with 3-methyladenine (3-MA) on the expressions of the proteins associated with autophagy (LC3, P62 and Beclin1), apoptosis (Bcl2 and Bax) and epithelial-mesenchymal transition (E-cadherin and Snail) were examined with Western blotting.	3-methyladenine	64-79	snail family transcriptional repressor 1	Homo sapiens	251-256
35365454-5	2022	The effects of melatonin treatment alone or in combination with 3-methyladenine (3-MA) on the expressions of the proteins associated with autophagy (LC3, P62 and Beclin1), apoptosis (Bcl2 and Bax) and epithelial-mesenchymal transition (E-cadherin and Snail) were examined with Western blotting.	3-methyladenine	81-85	nucleoporin 62	Homo sapiens	154-157
35365454-5	2022	The effects of melatonin treatment alone or in combination with 3-methyladenine (3-MA) on the expressions of the proteins associated with autophagy (LC3, P62 and Beclin1), apoptosis (Bcl2 and Bax) and epithelial-mesenchymal transition (E-cadherin and Snail) were examined with Western blotting.	3-methyladenine	81-85	beclin 1	Homo sapiens	162-169
35365454-5	2022	The effects of melatonin treatment alone or in combination with 3-methyladenine (3-MA) on the expressions of the proteins associated with autophagy (LC3, P62 and Beclin1), apoptosis (Bcl2 and Bax) and epithelial-mesenchymal transition (E-cadherin and Snail) were examined with Western blotting.	3-methyladenine	81-85	BCL2 apoptosis regulator	Homo sapiens	183-187
35365454-5	2022	The effects of melatonin treatment alone or in combination with 3-methyladenine (3-MA) on the expressions of the proteins associated with autophagy (LC3, P62 and Beclin1), apoptosis (Bcl2 and Bax) and epithelial-mesenchymal transition (E-cadherin and Snail) were examined with Western blotting.	3-methyladenine	81-85	BCL2 associated X, apoptosis regulator	Homo sapiens	192-195
35365454-5	2022	The effects of melatonin treatment alone or in combination with 3-methyladenine (3-MA) on the expressions of the proteins associated with autophagy (LC3, P62 and Beclin1), apoptosis (Bcl2 and Bax) and epithelial-mesenchymal transition (E-cadherin and Snail) were examined with Western blotting.	3-methyladenine	81-85	cadherin 1	Homo sapiens	236-246
35365454-5	2022	The effects of melatonin treatment alone or in combination with 3-methyladenine (3-MA) on the expressions of the proteins associated with autophagy (LC3, P62 and Beclin1), apoptosis (Bcl2 and Bax) and epithelial-mesenchymal transition (E-cadherin and Snail) were examined with Western blotting.	3-methyladenine	81-85	snail family transcriptional repressor 1	Homo sapiens	251-256
35365454-8	2022	Compared with melatonin treatment alone, melatonin treatment combined with 3-MA significantly decreased the expressions of Beclin1 (P < 0.001), LC3-II/LC3-I (P < 0.05), Bax (P < 0.01), and E-cadherin (P < 0.001) and increased the expressions of Bcl2 (P < 0.05), Snail, and Bcl2/Bax ratio (P < 0.01).	3-methyladenine	75-79	beclin 1	Homo sapiens	123-130
35365454-8	2022	Compared with melatonin treatment alone, melatonin treatment combined with 3-MA significantly decreased the expressions of Beclin1 (P < 0.001), LC3-II/LC3-I (P < 0.05), Bax (P < 0.01), and E-cadherin (P < 0.001) and increased the expressions of Bcl2 (P < 0.05), Snail, and Bcl2/Bax ratio (P < 0.01).	3-methyladenine	75-79	BCL2 associated X, apoptosis regulator	Homo sapiens	169-172
35365454-8	2022	Compared with melatonin treatment alone, melatonin treatment combined with 3-MA significantly decreased the expressions of Beclin1 (P < 0.001), LC3-II/LC3-I (P < 0.05), Bax (P < 0.01), and E-cadherin (P < 0.001) and increased the expressions of Bcl2 (P < 0.05), Snail, and Bcl2/Bax ratio (P < 0.01).	3-methyladenine	75-79	cadherin 1	Homo sapiens	189-199
35365454-8	2022	Compared with melatonin treatment alone, melatonin treatment combined with 3-MA significantly decreased the expressions of Beclin1 (P < 0.001), LC3-II/LC3-I (P < 0.05), Bax (P < 0.01), and E-cadherin (P < 0.001) and increased the expressions of Bcl2 (P < 0.05), Snail, and Bcl2/Bax ratio (P < 0.01).	3-methyladenine	75-79	BCL2 apoptosis regulator	Homo sapiens	245-249
35365454-8	2022	Compared with melatonin treatment alone, melatonin treatment combined with 3-MA significantly decreased the expressions of Beclin1 (P < 0.001), LC3-II/LC3-I (P < 0.05), Bax (P < 0.01), and E-cadherin (P < 0.001) and increased the expressions of Bcl2 (P < 0.05), Snail, and Bcl2/Bax ratio (P < 0.01).	3-methyladenine	75-79	snail family transcriptional repressor 1	Homo sapiens	262-267
35365454-8	2022	Compared with melatonin treatment alone, melatonin treatment combined with 3-MA significantly decreased the expressions of Beclin1 (P < 0.001), LC3-II/LC3-I (P < 0.05), Bax (P < 0.01), and E-cadherin (P < 0.001) and increased the expressions of Bcl2 (P < 0.05), Snail, and Bcl2/Bax ratio (P < 0.01).	3-methyladenine	75-79	BCL2 apoptosis regulator	Homo sapiens	273-277
35365454-8	2022	Compared with melatonin treatment alone, melatonin treatment combined with 3-MA significantly decreased the expressions of Beclin1 (P < 0.001), LC3-II/LC3-I (P < 0.05), Bax (P < 0.01), and E-cadherin (P < 0.001) and increased the expressions of Bcl2 (P < 0.05), Snail, and Bcl2/Bax ratio (P < 0.01).	3-methyladenine	75-79	BCL2 associated X, apoptosis regulator	Homo sapiens	278-281
35237297-12	2021	Finally, by inhibiting autophagy/mitophagy using 3-MA, the inhibitory effect of LRPPRC knockdown on proliferation was reversed.	3-methyladenine	49-53	leucine rich pentatricopeptide repeat containing	Homo sapiens	80-86
35154576-4	2022	Treatment of ferrostatin-1 (Ferr-1) and 3-methyladenine (3-MA) decreased iron deposition in IL-13-induced BEAS-2B cells and lung tissues of asthma mice, opposite to that in bronchoalveolar lavage fluid (BALF).	3-methyladenine	40-55	interleukin 13	Homo sapiens	92-97
35154576-4	2022	Treatment of ferrostatin-1 (Ferr-1) and 3-methyladenine (3-MA) decreased iron deposition in IL-13-induced BEAS-2B cells and lung tissues of asthma mice, opposite to that in bronchoalveolar lavage fluid (BALF).	3-methyladenine	57-61	interleukin 13	Homo sapiens	92-97
35186790-10	2022	In reverse, inhibition of autophagy using 3-methyladenine (3-MA) and glucose concentrations influenced the expression of IFNalpha-2a-induced ISG15 and IFITM1.	3-methyladenine	42-57	ISG15 ubiquitin like modifier	Homo sapiens	141-146
35186790-10	2022	In reverse, inhibition of autophagy using 3-methyladenine (3-MA) and glucose concentrations influenced the expression of IFNalpha-2a-induced ISG15 and IFITM1.	3-methyladenine	42-57	interferon induced transmembrane protein 1	Homo sapiens	151-157
35186790-10	2022	In reverse, inhibition of autophagy using 3-methyladenine (3-MA) and glucose concentrations influenced the expression of IFNalpha-2a-induced ISG15 and IFITM1.	3-methyladenine	59-63	ISG15 ubiquitin like modifier	Homo sapiens	141-146
35186790-10	2022	In reverse, inhibition of autophagy using 3-methyladenine (3-MA) and glucose concentrations influenced the expression of IFNalpha-2a-induced ISG15 and IFITM1.	3-methyladenine	59-63	interferon induced transmembrane protein 1	Homo sapiens	151-157
34998548-13	2022	Compared with the 1 muM ISO treatment group, 1 microM ISO + 10 mM 3-MA downregulated the abundance of ATGL, the ratio of p-HSL to HSL and LC3-II to LC3-I, and the glycerol content, whereas it upregulated the abundance of PLIN1 and p62.	3-methyladenine	66-70	patatin like phospholipase domain containing 2	Bos taurus	102-106
34998548-13	2022	Compared with the 1 muM ISO treatment group, 1 microM ISO + 10 mM 3-MA downregulated the abundance of ATGL, the ratio of p-HSL to HSL and LC3-II to LC3-I, and the glycerol content, whereas it upregulated the abundance of PLIN1 and p62.	3-methyladenine	66-70	lipase E, hormone sensitive type	Bos taurus	123-126
34998548-13	2022	Compared with the 1 muM ISO treatment group, 1 microM ISO + 10 mM 3-MA downregulated the abundance of ATGL, the ratio of p-HSL to HSL and LC3-II to LC3-I, and the glycerol content, whereas it upregulated the abundance of PLIN1 and p62.	3-methyladenine	66-70	lipase E, hormone sensitive type	Bos taurus	130-133
34998548-13	2022	Compared with the 1 muM ISO treatment group, 1 microM ISO + 10 mM 3-MA downregulated the abundance of ATGL, the ratio of p-HSL to HSL and LC3-II to LC3-I, and the glycerol content, whereas it upregulated the abundance of PLIN1 and p62.	3-methyladenine	66-70	perilipin 1	Bos taurus	221-226
35082401-10	2022	Blocking autophagy with 3-MA, chloroquine or siSQSTM1 prevented CRHBP degradation in HCC cells.	3-methyladenine	24-28	corticotropin releasing hormone binding protein	Homo sapiens	64-69
35082393-6	2022	In addition, ACT001-mediated inhibitory effect decreased when either ATG7 was downregulated or cells were cotreated with autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	141-156	autophagy related 7	Homo sapiens	69-73
34874916-0	2022	Anti-cachectic regulator analysis reveals novel Perp-dependent anti-tumorigenic properties of 3-methyladenine in pancreatic cancer.	3-methyladenine	94-109	p53 apoptosis effector related to PMP22	Homo sapiens	48-52
34874916-7	2022	Transcriptome analyses of 3-MA-treated tumor cells implicated Perp as a 3-MA target gene.	3-methyladenine	26-30	p53 apoptosis effector related to PMP22	Homo sapiens	62-66
34874916-8	2022	We subsequently 1) observed significantly higher expression of Perp in cancer cell lines compared to control cells, 2) noted a survival disadvantage associated with elevated Perp, and 3) found that 3-MA-associated Perp reduction inhibited tumor cell growth.	3-methyladenine	198-202	p53 apoptosis effector related to PMP22	Homo sapiens	63-67
34874916-8	2022	We subsequently 1) observed significantly higher expression of Perp in cancer cell lines compared to control cells, 2) noted a survival disadvantage associated with elevated Perp, and 3) found that 3-MA-associated Perp reduction inhibited tumor cell growth.	3-methyladenine	198-202	p53 apoptosis effector related to PMP22	Homo sapiens	174-178
34874916-8	2022	We subsequently 1) observed significantly higher expression of Perp in cancer cell lines compared to control cells, 2) noted a survival disadvantage associated with elevated Perp, and 3) found that 3-MA-associated Perp reduction inhibited tumor cell growth.	3-methyladenine	198-202	p53 apoptosis effector related to PMP22	Homo sapiens	214-218
34874916-10	2022	Taken together, we report a novel mechanism linking 3-MA to Perp inhibition, and further implicate PERP as a novel tumor promoting factor in pancreatic cancer.	3-methyladenine	52-56	p53 apoptosis effector related to PMP22	Homo sapiens	60-64
34874916-10	2022	Taken together, we report a novel mechanism linking 3-MA to Perp inhibition, and further implicate PERP as a novel tumor promoting factor in pancreatic cancer.	3-methyladenine	52-56	p53 apoptosis effector related to PMP22	Homo sapiens	99-103
35128864-5	2022	Mice of the EA+inhibitor group received intraperitoneal injection of mTOR inhibitor 3-methyladenine (1.5 mg kg-1 d-1) before the EA intervention each time.	3-methyladenine	84-99	mechanistic target of rapamycin kinase	Mus musculus	69-73
35237424-8	2022	A 6 h pretreatment of 3-MA increased PM2.5-induced oxidative damage and cellular inflammation as indicated by increasing protein levels of HO-1, TXNIP, Bnip3L/NIX and IL-8 gene expression.	3-methyladenine	22-26	heme oxygenase 1	Homo sapiens	139-143
35237424-8	2022	A 6 h pretreatment of 3-MA increased PM2.5-induced oxidative damage and cellular inflammation as indicated by increasing protein levels of HO-1, TXNIP, Bnip3L/NIX and IL-8 gene expression.	3-methyladenine	22-26	thioredoxin interacting protein	Homo sapiens	145-150
35237424-8	2022	A 6 h pretreatment of 3-MA increased PM2.5-induced oxidative damage and cellular inflammation as indicated by increasing protein levels of HO-1, TXNIP, Bnip3L/NIX and IL-8 gene expression.	3-methyladenine	22-26	BCL2 interacting protein 3 like	Homo sapiens	152-158
35237424-8	2022	A 6 h pretreatment of 3-MA increased PM2.5-induced oxidative damage and cellular inflammation as indicated by increasing protein levels of HO-1, TXNIP, Bnip3L/NIX and IL-8 gene expression.	3-methyladenine	22-26	BCL2 interacting protein 3 like	Homo sapiens	159-162
35237424-8	2022	A 6 h pretreatment of 3-MA increased PM2.5-induced oxidative damage and cellular inflammation as indicated by increasing protein levels of HO-1, TXNIP, Bnip3L/NIX and IL-8 gene expression.	3-methyladenine	22-26	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
35013122-6	2022	Moreover, the pharmacological inhibitor of autophagy, 3-MA, significantly inhibited p62 degradation and rescued oxidative stress-induced apoptosis in elder LECs.	3-methyladenine	54-58	sequestosome 1	Homo sapiens	84-87
34847836-9	2022	The autophagy inhibitor 3-MA significantly suppressed TGFbeta1 expression and tube formation in EA.hy926 cells.	3-methyladenine	24-28	transforming growth factor beta 1	Homo sapiens	54-62
35154454-8	2022	Finally, autophagy inhibitor 3-MA attenuated autophagy activation and rescued the inhibition of cell proliferation caused by FOXK2 knockdown, suggesting that FOXK2 silencing inhibits cell proliferation through up-regulating autophagy.	3-methyladenine	29-33	forkhead box K2	Homo sapiens	125-130
35154454-8	2022	Finally, autophagy inhibitor 3-MA attenuated autophagy activation and rescued the inhibition of cell proliferation caused by FOXK2 knockdown, suggesting that FOXK2 silencing inhibits cell proliferation through up-regulating autophagy.	3-methyladenine	29-33	forkhead box K2	Homo sapiens	158-163
3679410-5	1987	Thus, despite the fact that 3-meA is known to be formed at 10% of the level of 7-MeG in DNA following exposure of rats to methylating agents, the low "background" that we have observed indicates that urinary 3-meA should be a more sensitive indicator of methylation than 7-meG.	3-methyladenine	28-33	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	81-84
3679410-5	1987	Thus, despite the fact that 3-meA is known to be formed at 10% of the level of 7-MeG in DNA following exposure of rats to methylating agents, the low "background" that we have observed indicates that urinary 3-meA should be a more sensitive indicator of methylation than 7-meG.	3-methyladenine	208-213	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	273-276
3517634-4	1986	Extracts of ngs1 and NGS1+ strains contained approximately equal levels of an activity that removes 3-methyladenine (3MA) and 7-methylguanine (7MG) from DNA in vitro.	3-methyladenine	100-115	MRX complex nuclease subunit	Saccharomyces cerevisiae S288C	12-16
3517634-4	1986	Extracts of ngs1 and NGS1+ strains contained approximately equal levels of an activity that removes 3-methyladenine (3MA) and 7-methylguanine (7MG) from DNA in vitro.	3-methyladenine	100-115	MRX complex nuclease subunit	Saccharomyces cerevisiae S288C	21-25
3882435-5	1985	First, the autophagocytosis inhibitor, 3-methyladenine, reduces the EGF response, and second, the ability of insulin to inhibit protein breakdown by preventing the formation of autophagic vacuoles is overcome by EGF.	3-methyladenine	39-54	epidermal growth factor	Homo sapiens	68-71
3882435-5	1985	First, the autophagocytosis inhibitor, 3-methyladenine, reduces the EGF response, and second, the ability of insulin to inhibit protein breakdown by preventing the formation of autophagic vacuoles is overcome by EGF.	3-methyladenine	39-54	insulin	Homo sapiens	109-116
3882435-5	1985	First, the autophagocytosis inhibitor, 3-methyladenine, reduces the EGF response, and second, the ability of insulin to inhibit protein breakdown by preventing the formation of autophagic vacuoles is overcome by EGF.	3-methyladenine	39-54	epidermal growth factor	Homo sapiens	212-215
33895270-9	2021	Treatment with 3-MA, an autophagy inhibitor, eliminated the neuroprotective effects of SAHA on improving cognition in mice, activating autophagy and downregulating the NLRP3 inflammasome.	3-methyladenine	15-19	NLR family, pyrin domain containing 3	Mus musculus	168-173
33741330-5	2021	Modulation of autophagy by rapamycin, 3-methyladenine or ATG-5 knockdown regulated the expression of CAFs markers, suggesting a role of autophagy in the tumor promotion mechanism of TGF-beta1-induced CAFs activation.	3-methyladenine	38-53	transforming growth factor beta 1	Homo sapiens	182-191
33741330-7	2021	We demonstrated that TGF-beta1-activated CAFs promote tumor invasion, pulmonary metastasis and EMT, which act through autophagy and overexpression of FAP-alpha in both models, while autophagy inhibitor 3-methyladenine blocked these effects induced by TGF-beta1-activated CAFs.	3-methyladenine	202-217	transforming growth factor beta 1	Homo sapiens	21-30
33741330-7	2021	We demonstrated that TGF-beta1-activated CAFs promote tumor invasion, pulmonary metastasis and EMT, which act through autophagy and overexpression of FAP-alpha in both models, while autophagy inhibitor 3-methyladenine blocked these effects induced by TGF-beta1-activated CAFs.	3-methyladenine	202-217	fibroblast activation protein alpha	Homo sapiens	150-159
33741330-7	2021	We demonstrated that TGF-beta1-activated CAFs promote tumor invasion, pulmonary metastasis and EMT, which act through autophagy and overexpression of FAP-alpha in both models, while autophagy inhibitor 3-methyladenine blocked these effects induced by TGF-beta1-activated CAFs.	3-methyladenine	202-217	transforming growth factor beta 1	Homo sapiens	251-260
33184863-10	2021	Nonselective autophagy inhibitors, such as 3-methyladenine (3-MA) or wortmannin, abolished the protective effects of IL-33, resulting in an increase in both ER stress and apoptosis.	3-methyladenine	43-58	interleukin 33	Mus musculus	117-122
33184863-10	2021	Nonselective autophagy inhibitors, such as 3-methyladenine (3-MA) or wortmannin, abolished the protective effects of IL-33, resulting in an increase in both ER stress and apoptosis.	3-methyladenine	60-64	interleukin 33	Mus musculus	117-122
34060199-12	2021	Additionally, we detected that administration of 3-MA significantly reversed the protective effects of IP3 R overexpression on ESS-induced oxidative stress and inflammatory injury.	3-methyladenine	49-53	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	103-108
34052845-8	2021	In vivo, 3-MA and LY294002 repressed Ti particle-stimulated osteolysis and osteoclastogenesis and reduced expression of the pro-inflammatory factors TNF-alpha, IL-1beta, and IL-6.	3-methyladenine	9-13	tumor necrosis factor	Homo sapiens	149-158
34052845-8	2021	In vivo, 3-MA and LY294002 repressed Ti particle-stimulated osteolysis and osteoclastogenesis and reduced expression of the pro-inflammatory factors TNF-alpha, IL-1beta, and IL-6.	3-methyladenine	9-13	interleukin 1 alpha	Homo sapiens	160-168
34052845-8	2021	In vivo, 3-MA and LY294002 repressed Ti particle-stimulated osteolysis and osteoclastogenesis and reduced expression of the pro-inflammatory factors TNF-alpha, IL-1beta, and IL-6.	3-methyladenine	9-13	interleukin 6	Homo sapiens	174-178
34058434-9	2021	Autophagy treated with inhibitor 3-Methyladenine (3-MA) further increased TNF-alpha-induced osteogenesis inhibition of BMSCs.	3-methyladenine	33-48	tumor necrosis factor	Homo sapiens	74-83
34058434-9	2021	Autophagy treated with inhibitor 3-Methyladenine (3-MA) further increased TNF-alpha-induced osteogenesis inhibition of BMSCs.	3-methyladenine	50-54	tumor necrosis factor	Homo sapiens	74-83
34039348-0	2021	3-Methyladenine but not antioxidants to overcome BACH2-mediated bortezomib resistance in mantle cell lymphoma.	3-methyladenine	0-15	BTB domain and CNC homolog 2	Homo sapiens	49-54
34051206-10	2021	Importantly, these cellular processes were possibly mediated by mTOR/p70S6K signaling, as reflected by the offset of 3-MA in the immunosuppression of anemoside B4.	3-methyladenine	117-121	mechanistic target of rapamycin kinase	Mus musculus	64-68
34051206-10	2021	Importantly, these cellular processes were possibly mediated by mTOR/p70S6K signaling, as reflected by the offset of 3-MA in the immunosuppression of anemoside B4.	3-methyladenine	117-121	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	69-75
34021889-5	2021	3-MA, a classical inhibitor of autophagy, attenuated Cd-induced expansion of autophagosomes and apoptosis in the cells.	3-methyladenine	0-4	cathepsin D	Mus musculus	53-55
34011327-13	2021	Autophagy inhibition by 3-MA markedly reversed SAL-modulated changes in cell viability and NLRP3 expression in LPS-stimulated HUVECs.	3-methyladenine	24-28	NLR family pyrin domain containing 3	Homo sapiens	91-96
34045875-6	2021	Results: EGF treatment significantly increased the protein expression level of LC3 and decreased the protein level of P62 in HG-stimulated podocytes, which was attenuated by autophagy inhibitor, 3-methyladenine.	3-methyladenine	195-210	epidermal growth factor	Homo sapiens	9-12
34045875-6	2021	Results: EGF treatment significantly increased the protein expression level of LC3 and decreased the protein level of P62 in HG-stimulated podocytes, which was attenuated by autophagy inhibitor, 3-methyladenine.	3-methyladenine	195-210	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	79-82
34045875-6	2021	Results: EGF treatment significantly increased the protein expression level of LC3 and decreased the protein level of P62 in HG-stimulated podocytes, which was attenuated by autophagy inhibitor, 3-methyladenine.	3-methyladenine	195-210	nucleoporin 62	Homo sapiens	118-121
34045875-7	2021	EGF increased the cell proliferation and the protein expression levels of nephrin and synaptopodin, but reduced cell toxicity and cell apoptosis and protein expression level of cleaved caspase-3, which was partially antagonized by 3-methyladenine.	3-methyladenine	231-246	epidermal growth factor	Homo sapiens	0-3
34045875-7	2021	EGF increased the cell proliferation and the protein expression levels of nephrin and synaptopodin, but reduced cell toxicity and cell apoptosis and protein expression level of cleaved caspase-3, which was partially antagonized by 3-methyladenine.	3-methyladenine	231-246	caspase 3	Homo sapiens	185-194
34049220-15	2021	Moreover, Pt-induced anti-melanogenic activity through the downregulation of CREB-MITF pathway-mediated TRP-1/-2, tyrosinase expressions, melanosome formation, and melanin synthesis was substantially reversed due to 3-MA (autophagy inhibitor) pretreatment or LC3 silencing in B16F10 cells.	3-methyladenine	216-220	cAMP responsive element binding protein 1	Mus musculus	77-81
34049220-15	2021	Moreover, Pt-induced anti-melanogenic activity through the downregulation of CREB-MITF pathway-mediated TRP-1/-2, tyrosinase expressions, melanosome formation, and melanin synthesis was substantially reversed due to 3-MA (autophagy inhibitor) pretreatment or LC3 silencing in B16F10 cells.	3-methyladenine	216-220	melanogenesis associated transcription factor	Mus musculus	82-86
34049220-15	2021	Moreover, Pt-induced anti-melanogenic activity through the downregulation of CREB-MITF pathway-mediated TRP-1/-2, tyrosinase expressions, melanosome formation, and melanin synthesis was substantially reversed due to 3-MA (autophagy inhibitor) pretreatment or LC3 silencing in B16F10 cells.	3-methyladenine	216-220	tyrosinase	Mus musculus	114-124
34010608-8	2021	Inhibiting autophagy with 3-MA reversed the inhibition of NLRP3 inflammasome activation and diminished the neuroprotective effects of Gas6.	3-methyladenine	26-30	NLR family, pyrin domain containing 3	Mus musculus	58-63
34010608-8	2021	Inhibiting autophagy with 3-MA reversed the inhibition of NLRP3 inflammasome activation and diminished the neuroprotective effects of Gas6.	3-methyladenine	26-30	growth arrest specific 6	Mus musculus	134-138
33978839-11	2021	Apatinib inhibited the PI3K/Akt/mTOR pathway, while 3-MA and the combination of 3-MA and apatinib significantly activated the PI3K/Akt/mTOR pathway and inhibited autophagy.	3-methyladenine	52-56	AKT serine/threonine kinase 1	Homo sapiens	131-134
33978839-11	2021	Apatinib inhibited the PI3K/Akt/mTOR pathway, while 3-MA and the combination of 3-MA and apatinib significantly activated the PI3K/Akt/mTOR pathway and inhibited autophagy.	3-methyladenine	52-56	mechanistic target of rapamycin kinase	Homo sapiens	135-139
33978839-11	2021	Apatinib inhibited the PI3K/Akt/mTOR pathway, while 3-MA and the combination of 3-MA and apatinib significantly activated the PI3K/Akt/mTOR pathway and inhibited autophagy.	3-methyladenine	80-84	AKT serine/threonine kinase 1	Homo sapiens	131-134
33978839-11	2021	Apatinib inhibited the PI3K/Akt/mTOR pathway, while 3-MA and the combination of 3-MA and apatinib significantly activated the PI3K/Akt/mTOR pathway and inhibited autophagy.	3-methyladenine	80-84	mechanistic target of rapamycin kinase	Homo sapiens	135-139
33974963-4	2021	Treatment with MG132 or 3MA significantly increased the clinical hanging wire score and exacerbated alpha-motor neuron loss at 18 weeks in G93A mice, and increased the amount of ubiquitin, p62 aggregates, and BAG3 expression.	3-methyladenine	24-27	nucleoporin 62	Mus musculus	189-192
33974963-4	2021	Treatment with MG132 or 3MA significantly increased the clinical hanging wire score and exacerbated alpha-motor neuron loss at 18 weeks in G93A mice, and increased the amount of ubiquitin, p62 aggregates, and BAG3 expression.	3-methyladenine	24-27	BCL2-associated athanogene 3	Mus musculus	209-213
33955148-7	2021	Inhibition of autophagy using 6-amino-3-methypourine (3-MA) promoted apoptosis after irradiation or treatment of cells with curcumin and GLUT1 siRNA.	3-methyladenine	54-58	solute carrier family 2 member 1	Homo sapiens	137-142
33955148-8	2021	3-MA inhibited curcumin and GLUT1 siRNA-mediated non-apoptotic programmed cell death.	3-methyladenine	0-4	solute carrier family 2 member 1	Homo sapiens	28-33
33377585-8	2021	The curcumin-mediated protection against IL-1beta induced apoptosis was abolished when cells were treated with the autophagy inhibitor 3-MA or transfected with Beclin-1 small interfering RNA.	3-methyladenine	135-139	interleukin 1 alpha	Rattus norvegicus	41-49
32840732-12	2021	Meanwhile, the enhanced autophagic effects of emodin, such as the increment of LC3B II/ratio and the decrement of P62 expression, were suppressed by autophagy inhibitor 3-MA.	3-methyladenine	169-173	microtubule-associated protein 1 light chain 3 beta	Mus musculus	79-83
32840732-12	2021	Meanwhile, the enhanced autophagic effects of emodin, such as the increment of LC3B II/ratio and the decrement of P62 expression, were suppressed by autophagy inhibitor 3-MA.	3-methyladenine	169-173	nucleoporin 62	Mus musculus	114-117
33277707-7	2021	Conversely, inhibition of autophagy through 3MA significantly attenuated the expression level of DSPP (P < 0.05) and DMP1 (P < 0.05) as well as formation of mineralized nodules (P < 0.05), indicating the functional significance of autophagy in MTA-induced odontoblastic differentiation.	3-methyladenine	44-47	dentin sialophosphoprotein	Rattus norvegicus	97-101
33277707-7	2021	Conversely, inhibition of autophagy through 3MA significantly attenuated the expression level of DSPP (P < 0.05) and DMP1 (P < 0.05) as well as formation of mineralized nodules (P < 0.05), indicating the functional significance of autophagy in MTA-induced odontoblastic differentiation.	3-methyladenine	44-47	dentin matrix acidic phosphoprotein 1	Homo sapiens	117-121
33417226-5	2021	Autophagy inhibition by 3-methyladenine (3-MA), but not bafilomycin A1 (BAF1), reduced ADAM10 mature form by 49% (p < 0.05, n = 4) in the TFEB expressing HeLa cells.	3-methyladenine	24-39	ADAM metallopeptidase domain 10	Homo sapiens	87-93
33417226-5	2021	Autophagy inhibition by 3-methyladenine (3-MA), but not bafilomycin A1 (BAF1), reduced ADAM10 mature form by 49% (p < 0.05, n = 4) in the TFEB expressing HeLa cells.	3-methyladenine	24-39	transcription factor EB	Homo sapiens	138-142
33417226-5	2021	Autophagy inhibition by 3-methyladenine (3-MA), but not bafilomycin A1 (BAF1), reduced ADAM10 mature form by 49% (p < 0.05, n = 4) in the TFEB expressing HeLa cells.	3-methyladenine	41-45	ADAM metallopeptidase domain 10	Homo sapiens	87-93
33417226-5	2021	Autophagy inhibition by 3-methyladenine (3-MA), but not bafilomycin A1 (BAF1), reduced ADAM10 mature form by 49% (p < 0.05, n = 4) in the TFEB expressing HeLa cells.	3-methyladenine	41-45	transcription factor EB	Homo sapiens	138-142
33928642-13	2021	Furthermore, we found that Nkx2-3 enhanced autophagy level, while the autophagy inhibitor 3-MA eliminated the inhibitory effect of Nkx2-3 on VSMCs proliferation and migration both in vivo and in vitro.	3-methyladenine	90-94	NK3 homeobox 1	Homo sapiens	131-137
33866937-8	2021	Inhibition of autophagy by 3-methyladenine or interference of ATG5 or ATG7 attenuated HBx-induced cell cycle acceleration and the subsequent proliferative response via the induction of G1/S arrest.	3-methyladenine	27-42	X protein	Hepatitis B virus	86-89
33887379-7	2021	Furthermore, the PI3K inhibitor (LY294002 or 3-MA) and/or PAP reversed the Cd-induced upregulated expression of LC3 II, Beclin-1, and PI3K class III, with a synergy between PI3K inhibitor and PAP against Cd-induced autophagy.	3-methyladenine	45-49	beclin 1, autophagy related	Mus musculus	120-128
33870866-7	2021	Subsequent findings revealed that autophagosome accumulation was caused by the inhibition of autophagy flux by transfection mRFP-GFP-LC3 adenovirus in the presence of autophagy inhibitor 3-MA and CQ.	3-methyladenine	187-191	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	133-136
33878616-8	2021	Via using mitophagy inhibitor 3-methyladenine (3-MA), we further found that 3-MA counteracted the protective effect of 25HC on hepatic I/R injury and the NLRP3 inflammasome.	3-methyladenine	30-45	NLR family, pyrin domain containing 3	Rattus norvegicus	154-159
33878616-8	2021	Via using mitophagy inhibitor 3-methyladenine (3-MA), we further found that 3-MA counteracted the protective effect of 25HC on hepatic I/R injury and the NLRP3 inflammasome.	3-methyladenine	76-80	NLR family, pyrin domain containing 3	Rattus norvegicus	154-159
33360697-6	2021	Moreover, treatment with 3- methyladenine (3-MA) aggravated Cu-induced S-phase arrest in cell cycle; increased the apoptotic rate; increased p53, Bak1, Bax, Cyt C, and Caspase3/cleaved-caspase3 mRNA and protein levels; and decreased Bcl2 mRNA and protein levels.	3-methyladenine	25-41	BCL2 antagonist/killer 1	Gallus gallus	146-150
33360697-6	2021	Moreover, treatment with 3- methyladenine (3-MA) aggravated Cu-induced S-phase arrest in cell cycle; increased the apoptotic rate; increased p53, Bak1, Bax, Cyt C, and Caspase3/cleaved-caspase3 mRNA and protein levels; and decreased Bcl2 mRNA and protein levels.	3-methyladenine	25-41	caspase 3	Gallus gallus	168-176
33360697-6	2021	Moreover, treatment with 3- methyladenine (3-MA) aggravated Cu-induced S-phase arrest in cell cycle; increased the apoptotic rate; increased p53, Bak1, Bax, Cyt C, and Caspase3/cleaved-caspase3 mRNA and protein levels; and decreased Bcl2 mRNA and protein levels.	3-methyladenine	25-41	BCL2, apoptosis regulator	Gallus gallus	233-237
33360697-6	2021	Moreover, treatment with 3- methyladenine (3-MA) aggravated Cu-induced S-phase arrest in cell cycle; increased the apoptotic rate; increased p53, Bak1, Bax, Cyt C, and Caspase3/cleaved-caspase3 mRNA and protein levels; and decreased Bcl2 mRNA and protein levels.	3-methyladenine	43-47	BCL2 antagonist/killer 1	Gallus gallus	146-150
33360697-6	2021	Moreover, treatment with 3- methyladenine (3-MA) aggravated Cu-induced S-phase arrest in cell cycle; increased the apoptotic rate; increased p53, Bak1, Bax, Cyt C, and Caspase3/cleaved-caspase3 mRNA and protein levels; and decreased Bcl2 mRNA and protein levels.	3-methyladenine	43-47	caspase 3	Gallus gallus	168-176
33360697-6	2021	Moreover, treatment with 3- methyladenine (3-MA) aggravated Cu-induced S-phase arrest in cell cycle; increased the apoptotic rate; increased p53, Bak1, Bax, Cyt C, and Caspase3/cleaved-caspase3 mRNA and protein levels; and decreased Bcl2 mRNA and protein levels.	3-methyladenine	43-47	BCL2, apoptosis regulator	Gallus gallus	233-237
33848354-5	2021	Inhibition of the class III phosphoinositide 3-kinase (PI3K) VPS34 with 3-methyladenine (3-MA) or siRNA can not only inhibit abnormally enhanced autophagy but also inhibit glycolysis by inhibiting the location of epidermal growth factor receptor (EGFR) and the expression of hexokinase II (HK2).	3-methyladenine	72-87	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	28-53
33848354-5	2021	Inhibition of the class III phosphoinositide 3-kinase (PI3K) VPS34 with 3-methyladenine (3-MA) or siRNA can not only inhibit abnormally enhanced autophagy but also inhibit glycolysis by inhibiting the location of epidermal growth factor receptor (EGFR) and the expression of hexokinase II (HK2).	3-methyladenine	72-87	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	61-66
33848354-5	2021	Inhibition of the class III phosphoinositide 3-kinase (PI3K) VPS34 with 3-methyladenine (3-MA) or siRNA can not only inhibit abnormally enhanced autophagy but also inhibit glycolysis by inhibiting the location of epidermal growth factor receptor (EGFR) and the expression of hexokinase II (HK2).	3-methyladenine	72-87	epidermal growth factor receptor	Homo sapiens	213-245
33848354-5	2021	Inhibition of the class III phosphoinositide 3-kinase (PI3K) VPS34 with 3-methyladenine (3-MA) or siRNA can not only inhibit abnormally enhanced autophagy but also inhibit glycolysis by inhibiting the location of epidermal growth factor receptor (EGFR) and the expression of hexokinase II (HK2).	3-methyladenine	72-87	epidermal growth factor receptor	Homo sapiens	247-251
33848354-5	2021	Inhibition of the class III phosphoinositide 3-kinase (PI3K) VPS34 with 3-methyladenine (3-MA) or siRNA can not only inhibit abnormally enhanced autophagy but also inhibit glycolysis by inhibiting the location of epidermal growth factor receptor (EGFR) and the expression of hexokinase II (HK2).	3-methyladenine	72-87	hexokinase 2	Homo sapiens	290-293
33848354-5	2021	Inhibition of the class III phosphoinositide 3-kinase (PI3K) VPS34 with 3-methyladenine (3-MA) or siRNA can not only inhibit abnormally enhanced autophagy but also inhibit glycolysis by inhibiting the location of epidermal growth factor receptor (EGFR) and the expression of hexokinase II (HK2).	3-methyladenine	89-93	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	28-53
33848354-5	2021	Inhibition of the class III phosphoinositide 3-kinase (PI3K) VPS34 with 3-methyladenine (3-MA) or siRNA can not only inhibit abnormally enhanced autophagy but also inhibit glycolysis by inhibiting the location of epidermal growth factor receptor (EGFR) and the expression of hexokinase II (HK2).	3-methyladenine	89-93	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	61-66
33848354-5	2021	Inhibition of the class III phosphoinositide 3-kinase (PI3K) VPS34 with 3-methyladenine (3-MA) or siRNA can not only inhibit abnormally enhanced autophagy but also inhibit glycolysis by inhibiting the location of epidermal growth factor receptor (EGFR) and the expression of hexokinase II (HK2).	3-methyladenine	89-93	epidermal growth factor receptor	Homo sapiens	213-245
33848354-5	2021	Inhibition of the class III phosphoinositide 3-kinase (PI3K) VPS34 with 3-methyladenine (3-MA) or siRNA can not only inhibit abnormally enhanced autophagy but also inhibit glycolysis by inhibiting the location of epidermal growth factor receptor (EGFR) and the expression of hexokinase II (HK2).	3-methyladenine	89-93	epidermal growth factor receptor	Homo sapiens	247-251
33848354-5	2021	Inhibition of the class III phosphoinositide 3-kinase (PI3K) VPS34 with 3-methyladenine (3-MA) or siRNA can not only inhibit abnormally enhanced autophagy but also inhibit glycolysis by inhibiting the location of epidermal growth factor receptor (EGFR) and the expression of hexokinase II (HK2).	3-methyladenine	89-93	hexokinase 2	Homo sapiens	290-293
33846234-6	2021	The ability of rosuvastatin to inhibit apoptosis and p38 phosphorylation was suppressed by treatment with 3-methyladenine (3-MA; an autophagy inhibitor) but promoted by rapamycin (an autophagy activator) treatment.	3-methyladenine	106-121	mitogen-activated protein kinase 14	Mus musculus	53-56
33846234-6	2021	The ability of rosuvastatin to inhibit apoptosis and p38 phosphorylation was suppressed by treatment with 3-methyladenine (3-MA; an autophagy inhibitor) but promoted by rapamycin (an autophagy activator) treatment.	3-methyladenine	123-127	mitogen-activated protein kinase 14	Mus musculus	53-56
33749503-4	2021	Our data revealed that LC3-II formation and SQSTM1/p62 degradation were noted in H2O2-activated human platelets, which could be blocked by 3-methyladenine and bafilomycin A1, indicating that platelet activation may cause platelet autophagy.	3-methyladenine	139-154	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	23-26
33749503-4	2021	Our data revealed that LC3-II formation and SQSTM1/p62 degradation were noted in H2O2-activated human platelets, which could be blocked by 3-methyladenine and bafilomycin A1, indicating that platelet activation may cause platelet autophagy.	3-methyladenine	139-154	sequestosome 1	Homo sapiens	44-50
33749503-4	2021	Our data revealed that LC3-II formation and SQSTM1/p62 degradation were noted in H2O2-activated human platelets, which could be blocked by 3-methyladenine and bafilomycin A1, indicating that platelet activation may cause platelet autophagy.	3-methyladenine	139-154	sequestosome 1	Homo sapiens	51-54
33880372-7	2021	The autophagy inhibitor 3-methyladenine and chloroquine decreased apoptosis and cleaved-caspase-3 protein level and increased the Bcl-2/Bax ratio.	3-methyladenine	24-39	BCL2 apoptosis regulator	Homo sapiens	130-135
33880372-7	2021	The autophagy inhibitor 3-methyladenine and chloroquine decreased apoptosis and cleaved-caspase-3 protein level and increased the Bcl-2/Bax ratio.	3-methyladenine	24-39	BCL2 associated X, apoptosis regulator	Homo sapiens	136-139
32724177-10	2021	Cotreatment with the autophagy inhibitor 3-MA or bafilomycin A1 abrogated the in vivo and in vitro neuroprotective effects of GM1 ganglioside.	3-methyladenine	41-45	coenzyme Q10A	Mus musculus	126-129
33987329-8	2021	Furthermore, 3-methyladenine, an autophagy inhibitor, abolished lycopene"s inhibitory effect on the NLRP3 inflammasome in KCs, which led to increased hepatic IR injury.	3-methyladenine	13-28	NLR family, pyrin domain containing 3	Mus musculus	100-105
32726570-9	2021	Concurrently, autophagy inhibitor 3-methyladenine (3-MA) treatment exhibited the same variation trends with IGF-1.	3-methyladenine	34-49	insulin like growth factor 1	Homo sapiens	108-113
32726570-9	2021	Concurrently, autophagy inhibitor 3-methyladenine (3-MA) treatment exhibited the same variation trends with IGF-1.	3-methyladenine	51-55	insulin like growth factor 1	Homo sapiens	108-113
33230801-8	2021	In addition, human DPCs incubated in differentiation medium predominantly upregulated MAP1LC3C, which selectively decreased by 3MA but not by autophagy enhancer trehalose.	3-methyladenine	127-130	microtubule associated protein 1 light chain 3 gamma	Homo sapiens	86-94
33352257-6	2021	Further analysis indicated that a certain dosage of 3-MA and rapamycin decreased apoptosis and the caspase-3 expression, which suggested that As-induced autophagy regulated AML-12 cells apoptosis through the expressions of PI3K, mTOR, P62 and Bcl-2.	3-methyladenine	52-56	caspase 3	Mus musculus	99-108
33352257-6	2021	Further analysis indicated that a certain dosage of 3-MA and rapamycin decreased apoptosis and the caspase-3 expression, which suggested that As-induced autophagy regulated AML-12 cells apoptosis through the expressions of PI3K, mTOR, P62 and Bcl-2.	3-methyladenine	52-56	mechanistic target of rapamycin kinase	Mus musculus	229-233
33352257-6	2021	Further analysis indicated that a certain dosage of 3-MA and rapamycin decreased apoptosis and the caspase-3 expression, which suggested that As-induced autophagy regulated AML-12 cells apoptosis through the expressions of PI3K, mTOR, P62 and Bcl-2.	3-methyladenine	52-56	nucleoporin 62	Mus musculus	235-238
33352257-6	2021	Further analysis indicated that a certain dosage of 3-MA and rapamycin decreased apoptosis and the caspase-3 expression, which suggested that As-induced autophagy regulated AML-12 cells apoptosis through the expressions of PI3K, mTOR, P62 and Bcl-2.	3-methyladenine	52-56	B cell leukemia/lymphoma 2	Mus musculus	243-248
33968659-9	2021	The use of autophagy inhibitors 3-methyladenine (3-MA) could reverse the protective effect of METTL3 on TCam-2 cells.	3-methyladenine	32-47	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	94-100
33968659-9	2021	The use of autophagy inhibitors 3-methyladenine (3-MA) could reverse the protective effect of METTL3 on TCam-2 cells.	3-methyladenine	49-53	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	94-100
33775188-4	2021	3-Methyladenine (inhibitors of autophagy) and rapamycin (activator of autophagy) respectively inhibits or activates Ang II-induced autophagy levels.	3-methyladenine	0-15	angiotensinogen	Homo sapiens	116-122
33648977-6	2021	Inhibition of autophagy with 3-MA abrogated the development of kidney damage and attenuated renal fibrosis, macrophage infiltration, and expression of NLRP3 and IL-1beta in injured kidneys.	3-methyladenine	29-33	NLR family, pyrin domain containing 3	Rattus norvegicus	151-156
33648977-6	2021	Inhibition of autophagy with 3-MA abrogated the development of kidney damage and attenuated renal fibrosis, macrophage infiltration, and expression of NLRP3 and IL-1beta in injured kidneys.	3-methyladenine	29-33	interleukin 1 alpha	Rattus norvegicus	161-169
33833752-7	2021	Then, MAVS was degraded by using VP35 in a dose-dependent manner, and 3-MA (the autophagy pathway inhibitor) significantly blocked the degradation, meaning that MAVS was degraded by using VP35 in the autophagy pathway.	3-methyladenine	70-74	mitochondrial antiviral signaling protein	Homo sapiens	161-165
33828547-5	2021	Moreover, treatment of an autophagic inhibitor 3-methyladenine (3-MA) either during CS-initiated sensitization or during elastin provocation significantly inhibited the bronchitis-like phenotypes in mice.	3-methyladenine	47-62	elastin	Mus musculus	121-128
33828547-5	2021	Moreover, treatment of an autophagic inhibitor 3-methyladenine (3-MA) either during CS-initiated sensitization or during elastin provocation significantly inhibited the bronchitis-like phenotypes in mice.	3-methyladenine	64-68	elastin	Mus musculus	121-128
33828547-7	2021	CS extract triggered MMP12 expression in cultured macrophages, which was attenuated by autophagy impairment (Becn+/- or Lc3b-/ -) or inhibition (3-MA or Spautin-1).	3-methyladenine	145-149	matrix metallopeptidase 12	Mus musculus	21-26
33731670-7	2021	More importantly, autophagic inhibition by the suppressors 3-methyladenine (3-MA) and LY294002 significantly potentiated cytotoxicity and apoptosis in HER2-positive GC cells in vitro, while the combined use of LY294002 and T-DM1 elicited potent anti-GC efficacy in vivo.	3-methyladenine	59-74	erb-b2 receptor tyrosine kinase 2	Homo sapiens	151-155
33731670-7	2021	More importantly, autophagic inhibition by the suppressors 3-methyladenine (3-MA) and LY294002 significantly potentiated cytotoxicity and apoptosis in HER2-positive GC cells in vitro, while the combined use of LY294002 and T-DM1 elicited potent anti-GC efficacy in vivo.	3-methyladenine	76-80	erb-b2 receptor tyrosine kinase 2	Homo sapiens	151-155
33666540-7	2021	Thyroxine and 3-methyladenine give stability to human transthyretin (TTR) and activate autophagy, respectively, which are associated with the pathogenesis of Alzheimer"s disease.Conclusion: The result shows the potential of TP 3-in-1  juice which is rich in anthocyanins in improving cognitive function, particularly learning, memory, processing speed, sequencing, mental flexibility and visual-motor skills domains, among middle-aged women.	3-methyladenine	14-29	transthyretin	Homo sapiens	54-67
33666540-7	2021	Thyroxine and 3-methyladenine give stability to human transthyretin (TTR) and activate autophagy, respectively, which are associated with the pathogenesis of Alzheimer"s disease.Conclusion: The result shows the potential of TP 3-in-1  juice which is rich in anthocyanins in improving cognitive function, particularly learning, memory, processing speed, sequencing, mental flexibility and visual-motor skills domains, among middle-aged women.	3-methyladenine	14-29	transthyretin	Homo sapiens	69-72
33688170-8	2021	In addition, DHA notably induced the apoptosis of TGF-beta-stimulated HTFs by increasing the ROS levels, while these increases were partially reversed by 3-methyladenine.	3-methyladenine	154-169	transforming growth factor alpha	Homo sapiens	50-58
33788710-9	2021	In addition, pre-treatment of PC-3 cells with specific inhibitor of autophagy (3-methyladenine) and co-treatment with alpha-santalol attenuated the expression of LC3-II and phospho-AKT, and significantly reduced the cell viability.	3-methyladenine	79-94	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	162-165
33788710-9	2021	In addition, pre-treatment of PC-3 cells with specific inhibitor of autophagy (3-methyladenine) and co-treatment with alpha-santalol attenuated the expression of LC3-II and phospho-AKT, and significantly reduced the cell viability.	3-methyladenine	79-94	AKT serine/threonine kinase 1	Homo sapiens	181-184
33242459-9	2021	However, autophagy inhibitor 3-Methyladenine (3-MA) can slow down the downregulation of Cx43 induced by Pb in H9c2 cells.	3-methyladenine	29-44	gap junction protein, alpha 1	Rattus norvegicus	88-92
33242459-9	2021	However, autophagy inhibitor 3-Methyladenine (3-MA) can slow down the downregulation of Cx43 induced by Pb in H9c2 cells.	3-methyladenine	46-50	gap junction protein, alpha 1	Rattus norvegicus	88-92
33361403-10	2021	Furthermore, autophagy inhibition by 3-methyladenine significantly attenuated SIRT1 overexpression-mediated pro-inflammatory cytokine production.	3-methyladenine	37-52	sirtuin 1	Mus musculus	78-83
33278393-6	2021	Additionally, the mechanism by which prolonged CI affected autophagy was investigated through determination of the molecules related to the mTOR pathway after treatment with 3-Methyladenine (3-MA), rapamycin and an adenosine triphosphate (ATP) synthase inhibitor oligomycin (OM).	3-methyladenine	174-189	mechanistic target of rapamycin kinase	Rattus norvegicus	140-144
33278393-6	2021	Additionally, the mechanism by which prolonged CI affected autophagy was investigated through determination of the molecules related to the mTOR pathway after treatment with 3-Methyladenine (3-MA), rapamycin and an adenosine triphosphate (ATP) synthase inhibitor oligomycin (OM).	3-methyladenine	191-195	mechanistic target of rapamycin kinase	Rattus norvegicus	140-144
33106949-9	2021	We then linked these events with hypothyroidism-induced apoptosis and loss of hippocampal neurons, where we observed that like thyroxine, IL-1Ra and autophagy inhibitor, 3-methyladenine, reduced the cleaved caspase-3 and TUNEL-stained apoptotic neurons and enhanced Nissl-stained neuronal count in methimazole-treated rats.	3-methyladenine	170-185	interleukin 1 receptor antagonist	Rattus norvegicus	138-144
33106949-9	2021	We then linked these events with hypothyroidism-induced apoptosis and loss of hippocampal neurons, where we observed that like thyroxine, IL-1Ra and autophagy inhibitor, 3-methyladenine, reduced the cleaved caspase-3 and TUNEL-stained apoptotic neurons and enhanced Nissl-stained neuronal count in methimazole-treated rats.	3-methyladenine	170-185	caspase 3	Rattus norvegicus	207-216
33495826-14	2021	The FAM225B overexpression-induced increase of scar fibroblast proliferation and migration was significantly reversed by 3-methyladenine administration.	3-methyladenine	121-136	family with sequence similarity 225 member B	Homo sapiens	4-11
33631916-10	2021	These effects of G-CSF were abrogated by 3-methyladenine, an autophagy inhibitor.	3-methyladenine	41-56	colony stimulating factor 3	Rattus norvegicus	17-22
33717152-11	2021	Furthermore, Parkin deletion or pretreated with 3MA (autophagy inhibitor) exacerbated these detrimental actions of IH, which was accompanied with NLRP3 inflammasome activation.	3-methyladenine	48-51	NLR family, pyrin domain containing 3	Mus musculus	146-151
33664668-5	2021	Ang II-induced autophagic increases were potentiated by inhibition of PI3KC1 with LY294002, but were impaired by inhibition of PI3KC3 with 3-methyladenine (3-MA).	3-methyladenine	139-154	angiotensinogen	Rattus norvegicus	0-6
33664668-5	2021	Ang II-induced autophagic increases were potentiated by inhibition of PI3KC1 with LY294002, but were impaired by inhibition of PI3KC3 with 3-methyladenine (3-MA).	3-methyladenine	156-160	angiotensinogen	Rattus norvegicus	0-6
33594310-10	2021	Finally, the expression of p-mTOR was suppressed in a dose-dependent manner after Tan IIA treatment but partially restored when Tan IIA treatment was combined with 3-MA intervention.	3-methyladenine	164-168	serine/threonine-protein kinase mTOR	Oryctolagus cuniculus	29-33
33146448-9	2021	Furthermore, VD3 enhanced the AMI-caused inhibition of PI3K, p-AKT and p-mTOR expression, which was conversely reversed by addition of 3-methyladenine in vitro.	3-methyladenine	135-150	thymoma viral proto-oncogene 1	Mus musculus	63-66
33146448-9	2021	Furthermore, VD3 enhanced the AMI-caused inhibition of PI3K, p-AKT and p-mTOR expression, which was conversely reversed by addition of 3-methyladenine in vitro.	3-methyladenine	135-150	mechanistic target of rapamycin kinase	Mus musculus	73-77
33348253-4	2021	Besides, co-treatment with Mo and 3-MA dramatically increased LDH release, ROS level, hydrogen peroxide (H2O2) and malondialdehyde (MDA) contents as well as cell dam age, reduced cell viability, the activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), MMP, mitochondrial mass, mitochondrial RCR and OPR compared to treatment with Mo alone.	3-methyladenine	34-38	superoxide dismutase 1	Homo sapiens	246-266
33348253-4	2021	Besides, co-treatment with Mo and 3-MA dramatically increased LDH release, ROS level, hydrogen peroxide (H2O2) and malondialdehyde (MDA) contents as well as cell dam age, reduced cell viability, the activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), MMP, mitochondrial mass, mitochondrial RCR and OPR compared to treatment with Mo alone.	3-methyladenine	34-38	superoxide dismutase 1	Homo sapiens	268-271
33348253-4	2021	Besides, co-treatment with Mo and 3-MA dramatically increased LDH release, ROS level, hydrogen peroxide (H2O2) and malondialdehyde (MDA) contents as well as cell dam age, reduced cell viability, the activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), MMP, mitochondrial mass, mitochondrial RCR and OPR compared to treatment with Mo alone.	3-methyladenine	34-38	catalase	Homo sapiens	274-282
33348253-4	2021	Besides, co-treatment with Mo and 3-MA dramatically increased LDH release, ROS level, hydrogen peroxide (H2O2) and malondialdehyde (MDA) contents as well as cell dam age, reduced cell viability, the activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), MMP, mitochondrial mass, mitochondrial RCR and OPR compared to treatment with Mo alone.	3-methyladenine	34-38	catalase	Homo sapiens	284-287
33360085-13	2021	Treatment with 3-MA abolished osteoclast differentiation which was enhanced by SDC4, indicating that SDC4 promotes osteoclast differentiation through activating autophagy.	3-methyladenine	15-19	syndecan 4	Rattus norvegicus	79-83
33360085-13	2021	Treatment with 3-MA abolished osteoclast differentiation which was enhanced by SDC4, indicating that SDC4 promotes osteoclast differentiation through activating autophagy.	3-methyladenine	15-19	syndecan 4	Rattus norvegicus	101-105
33314691-6	2021	Additionally, the autophagy inhibitor 3-methyladenine reversed the inhibitory effects of LETM1 silencing on proliferation and stemness, whereas the autophagy activator rapamycin had the opposite effects.	3-methyladenine	38-53	leucine zipper and EF-hand containing transmembrane protein 1	Homo sapiens	89-94
33076741-9	2021	Treatment with 3-methyladenine (3-MA), a selective inhibitor of autophagy, reversed the downregulated apoptosis-related markers by IF.	3-methyladenine	15-30	cobalamin binding intrinsic factor	Rattus norvegicus	131-133
33076741-9	2021	Treatment with 3-methyladenine (3-MA), a selective inhibitor of autophagy, reversed the downregulated apoptosis-related markers by IF.	3-methyladenine	32-36	cobalamin binding intrinsic factor	Rattus norvegicus	131-133
33584263-8	2020	Blocking autophagy activation with 3-methyladenine (3-MA) in rats treated with ghrelin and 6-OHDA showed no notable change in apoptosis-related markers, while blocking autophagosome fusion with lysosomes with chloroquine could notably reverse the downregulation of bax/bcl-2 ratio and cleaved caspase three expression by ghrelin.	3-methyladenine	35-50	ghrelin and obestatin prepropeptide	Rattus norvegicus	79-86
33584263-8	2020	Blocking autophagy activation with 3-methyladenine (3-MA) in rats treated with ghrelin and 6-OHDA showed no notable change in apoptosis-related markers, while blocking autophagosome fusion with lysosomes with chloroquine could notably reverse the downregulation of bax/bcl-2 ratio and cleaved caspase three expression by ghrelin.	3-methyladenine	52-56	ghrelin and obestatin prepropeptide	Rattus norvegicus	79-86
33584263-8	2020	Blocking autophagy activation with 3-methyladenine (3-MA) in rats treated with ghrelin and 6-OHDA showed no notable change in apoptosis-related markers, while blocking autophagosome fusion with lysosomes with chloroquine could notably reverse the downregulation of bax/bcl-2 ratio and cleaved caspase three expression by ghrelin.	3-methyladenine	52-56	BCL2 associated X, apoptosis regulator	Rattus norvegicus	265-268
33584263-8	2020	Blocking autophagy activation with 3-methyladenine (3-MA) in rats treated with ghrelin and 6-OHDA showed no notable change in apoptosis-related markers, while blocking autophagosome fusion with lysosomes with chloroquine could notably reverse the downregulation of bax/bcl-2 ratio and cleaved caspase three expression by ghrelin.	3-methyladenine	52-56	BCL2, apoptosis regulator	Rattus norvegicus	269-274
33584263-8	2020	Blocking autophagy activation with 3-methyladenine (3-MA) in rats treated with ghrelin and 6-OHDA showed no notable change in apoptosis-related markers, while blocking autophagosome fusion with lysosomes with chloroquine could notably reverse the downregulation of bax/bcl-2 ratio and cleaved caspase three expression by ghrelin.	3-methyladenine	52-56	ghrelin and obestatin prepropeptide	Rattus norvegicus	321-328
33462182-14	2021	More importantly, ATO promoted autophagy in the aorta of ApoE-/- mice and reduced atherosclerotic lesions in early AS, which were reversed by 3-MA treatment.	3-methyladenine	142-146	apolipoprotein E	Mus musculus	57-61
33436008-11	2021	In addition, CDCA4-inhibited EMT, migration and invasion could be partially aggravated by autophagy activator, rapamycin, and reversed by autophagy inhibitor, 3-MA.	3-methyladenine	159-163	cell division cycle associated 4	Homo sapiens	13-18
33436008-12	2021	Correspondingly, the application of rapamycin or 3-MA to CDCA4 knockdown cells showed the opposite effects.	3-methyladenine	49-53	cell division cycle associated 4	Homo sapiens	57-62
33421149-11	2021	Meanwhile, cleaved caspase-3 dependent cell death was promoted with the presence of 3-MA in MCMV infected MEFs and eyecups, while RIPK1/RIPK3/MLKL pathway was inhibited by 3-MA in eyecups.	3-methyladenine	84-88	caspase 3	Homo sapiens	19-28
33421149-11	2021	Meanwhile, cleaved caspase-3 dependent cell death was promoted with the presence of 3-MA in MCMV infected MEFs and eyecups, while RIPK1/RIPK3/MLKL pathway was inhibited by 3-MA in eyecups.	3-methyladenine	172-176	caspase 3	Homo sapiens	19-28
33421149-11	2021	Meanwhile, cleaved caspase-3 dependent cell death was promoted with the presence of 3-MA in MCMV infected MEFs and eyecups, while RIPK1/RIPK3/MLKL pathway was inhibited by 3-MA in eyecups.	3-methyladenine	172-176	receptor interacting serine/threonine kinase 1	Homo sapiens	130-135
33421149-11	2021	Meanwhile, cleaved caspase-3 dependent cell death was promoted with the presence of 3-MA in MCMV infected MEFs and eyecups, while RIPK1/RIPK3/MLKL pathway was inhibited by 3-MA in eyecups.	3-methyladenine	172-176	receptor interacting serine/threonine kinase 3	Homo sapiens	136-141
33421149-11	2021	Meanwhile, cleaved caspase-3 dependent cell death was promoted with the presence of 3-MA in MCMV infected MEFs and eyecups, while RIPK1/RIPK3/MLKL pathway was inhibited by 3-MA in eyecups.	3-methyladenine	172-176	mixed lineage kinase domain like pseudokinase	Homo sapiens	142-146
33421149-12	2021	CONCLUSIONS: Inhibition of autophagy by 3-MA restricts virus replication and promotes caspase-3 dependent apoptosis in the eyecup and MEFs with MCMV infection.	3-methyladenine	40-44	caspase 3	Homo sapiens	86-95
33613969-9	2021	The LC3-II/LC3-I ratio was decreased after ERS inhibition with 4-PBA, but GRP78 and CHOP expressions were enhanced after autophagy inhibition with 3-MA.	3-methyladenine	147-151	heat shock protein family A (Hsp70) member 5	Homo sapiens	74-79
33613969-9	2021	The LC3-II/LC3-I ratio was decreased after ERS inhibition with 4-PBA, but GRP78 and CHOP expressions were enhanced after autophagy inhibition with 3-MA.	3-methyladenine	147-151	DNA damage inducible transcript 3	Homo sapiens	84-88
33613969-10	2021	CSC-induced apoptosis was further increased, Bax expressions and cleaved-caspase 3/pro-caspase 3 ratio were improved, but Bcl-2 expressions were decreased after 3-MA or 4-PBA treatment.	3-methyladenine	161-165	caspase 3	Homo sapiens	83-96
33613969-10	2021	CSC-induced apoptosis was further increased, Bax expressions and cleaved-caspase 3/pro-caspase 3 ratio were improved, but Bcl-2 expressions were decreased after 3-MA or 4-PBA treatment.	3-methyladenine	161-165	BCL2 apoptosis regulator	Homo sapiens	122-127
33349212-0	2021	3-MA Enhanced Chemosensitivity in Cisplatin Resistant Hypopharyngeal Squamous Carcinoma Cells via Inhibiting Beclin -1 Mediated Autophagy.	3-methyladenine	0-4	beclin 1	Homo sapiens	109-118
33349212-20	2021	Furthermore, Western blot showed that expression of Beclin1, lc3-I, lc3-II, atg-5 protein decreased significantly after 3-MA intervention, while the expression of p62 up-regulated, which also confirmed autophagy flow was blocked.	3-methyladenine	120-124	beclin 1	Homo sapiens	52-59
33349212-20	2021	Furthermore, Western blot showed that expression of Beclin1, lc3-I, lc3-II, atg-5 protein decreased significantly after 3-MA intervention, while the expression of p62 up-regulated, which also confirmed autophagy flow was blocked.	3-methyladenine	120-124	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	61-64
33349212-20	2021	Furthermore, Western blot showed that expression of Beclin1, lc3-I, lc3-II, atg-5 protein decreased significantly after 3-MA intervention, while the expression of p62 up-regulated, which also confirmed autophagy flow was blocked.	3-methyladenine	120-124	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	68-71
33349212-20	2021	Furthermore, Western blot showed that expression of Beclin1, lc3-I, lc3-II, atg-5 protein decreased significantly after 3-MA intervention, while the expression of p62 up-regulated, which also confirmed autophagy flow was blocked.	3-methyladenine	120-124	autophagy related 5	Homo sapiens	76-81
33349212-20	2021	Furthermore, Western blot showed that expression of Beclin1, lc3-I, lc3-II, atg-5 protein decreased significantly after 3-MA intervention, while the expression of p62 up-regulated, which also confirmed autophagy flow was blocked.	3-methyladenine	120-124	nucleoporin 62	Homo sapiens	163-166
33349212-22	2021	The use of 3-MA can significantly reduce autophagy level and arresting its cell cycle, promote apoptosis and reverse the cisplatin resistance condition, this effect is partly mediated by inhibition of Beclin-1 expression.	3-methyladenine	11-15	beclin 1	Homo sapiens	201-209
33217525-10	2021	Moreover, autophagy inhibitor 3-methyladenine (3MA) attenuated PAT-induced increase in cytoplasmic cathepsin B expression, and subsequent LDH release, the activation of NLRP3 inflamosomes, pyroptotic cell death, and inflammation.	3-methyladenine	30-45	cathepsin B	Mus musculus	99-110
33217525-10	2021	Moreover, autophagy inhibitor 3-methyladenine (3MA) attenuated PAT-induced increase in cytoplasmic cathepsin B expression, and subsequent LDH release, the activation of NLRP3 inflamosomes, pyroptotic cell death, and inflammation.	3-methyladenine	30-45	NLR family, pyrin domain containing 3	Mus musculus	169-174
33217525-10	2021	Moreover, autophagy inhibitor 3-methyladenine (3MA) attenuated PAT-induced increase in cytoplasmic cathepsin B expression, and subsequent LDH release, the activation of NLRP3 inflamosomes, pyroptotic cell death, and inflammation.	3-methyladenine	47-50	cathepsin B	Mus musculus	99-110
33217525-10	2021	Moreover, autophagy inhibitor 3-methyladenine (3MA) attenuated PAT-induced increase in cytoplasmic cathepsin B expression, and subsequent LDH release, the activation of NLRP3 inflamosomes, pyroptotic cell death, and inflammation.	3-methyladenine	47-50	NLR family, pyrin domain containing 3	Mus musculus	169-174
33408300-6	2021	Moreover, pharmacological autophagy inhibitor 3-Methyladenine could reverse GO-induced LC3B and p62 expression levels, reduce expression levels of IL-6, IL-8, TLR4, and CXCL2, and increase the level of IL-10.	3-methyladenine	46-61	microtubule-associated protein 1 light chain 3 beta	Mus musculus	87-91
33408300-6	2021	Moreover, pharmacological autophagy inhibitor 3-Methyladenine could reverse GO-induced LC3B and p62 expression levels, reduce expression levels of IL-6, IL-8, TLR4, and CXCL2, and increase the level of IL-10.	3-methyladenine	46-61	nucleoporin 62	Mus musculus	96-99
33408300-6	2021	Moreover, pharmacological autophagy inhibitor 3-Methyladenine could reverse GO-induced LC3B and p62 expression levels, reduce expression levels of IL-6, IL-8, TLR4, and CXCL2, and increase the level of IL-10.	3-methyladenine	46-61	interleukin 6	Mus musculus	147-151
33408300-6	2021	Moreover, pharmacological autophagy inhibitor 3-Methyladenine could reverse GO-induced LC3B and p62 expression levels, reduce expression levels of IL-6, IL-8, TLR4, and CXCL2, and increase the level of IL-10.	3-methyladenine	46-61	chemokine (C-X-C motif) ligand 15	Mus musculus	153-157
33408300-6	2021	Moreover, pharmacological autophagy inhibitor 3-Methyladenine could reverse GO-induced LC3B and p62 expression levels, reduce expression levels of IL-6, IL-8, TLR4, and CXCL2, and increase the level of IL-10.	3-methyladenine	46-61	toll-like receptor 4	Mus musculus	159-163
33408300-6	2021	Moreover, pharmacological autophagy inhibitor 3-Methyladenine could reverse GO-induced LC3B and p62 expression levels, reduce expression levels of IL-6, IL-8, TLR4, and CXCL2, and increase the level of IL-10.	3-methyladenine	46-61	chemokine (C-X-C motif) ligand 2	Mus musculus	169-174
33408300-6	2021	Moreover, pharmacological autophagy inhibitor 3-Methyladenine could reverse GO-induced LC3B and p62 expression levels, reduce expression levels of IL-6, IL-8, TLR4, and CXCL2, and increase the level of IL-10.	3-methyladenine	46-61	interleukin 10	Mus musculus	202-207
33127511-8	2021	In addition, the inhibition of autophagy by 3-methyladenine limited the role of EI24 in these processes.	3-methyladenine	44-59	etoposide induced 2.4 mRNA	Mus musculus	80-84
33380391-4	2020	The effect of 3-MA treatment for 24 h on LPS-induced apoptosis of mDPC-23 cells was evaluated by detecting the expressions of apoptosis-related proteins caspase-3 and Bax using Western blotting.	3-methyladenine	14-18	caspase 3	Mus musculus	153-162
33380391-4	2020	The effect of 3-MA treatment for 24 h on LPS-induced apoptosis of mDPC-23 cells was evaluated by detecting the expressions of apoptosis-related proteins caspase-3 and Bax using Western blotting.	3-methyladenine	14-18	BCL2-associated X protein	Mus musculus	167-170
33380391-7	2020	Treatment with 3-MA markedly lowered caspase-3 and Bax protein expressions in LPS-stimulated cells (P < 0.05).	3-methyladenine	15-19	caspase 3	Mus musculus	37-46
33380391-7	2020	Treatment with 3-MA markedly lowered caspase-3 and Bax protein expressions in LPS-stimulated cells (P < 0.05).	3-methyladenine	15-19	BCL2-associated X protein	Mus musculus	51-54
33374865-7	2020	When the formation of the autophagosome is blocked with 3-methyladenine (3-MA), monoubiquitinated PEPC accumulates as a result.	3-methyladenine	56-71	phosphoenolpyruvate carboxylase	Nicotiana tabacum	98-102
33374865-7	2020	When the formation of the autophagosome is blocked with 3-methyladenine (3-MA), monoubiquitinated PEPC accumulates as a result.	3-methyladenine	73-77	phosphoenolpyruvate carboxylase	Nicotiana tabacum	98-102
32712090-6	2020	Intrathecal injection of 3-MA (a mTOR agonist) or EX-527 (an inhibitor of Sirt1) partially antagonized lycopene-induced analgesia.	3-methyladenine	25-29	mechanistic target of rapamycin kinase	Rattus norvegicus	33-37
33317171-6	2020	In contrast, OGT inhibitor-mediated autophagy was significantly attenuated by 3-methyladenine (3-MA), a blocker of autophagosome formation.	3-methyladenine	78-93	O-linked N-acetylglucosamine (GlcNAc) transferase	Rattus norvegicus	13-16
33317171-6	2020	In contrast, OGT inhibitor-mediated autophagy was significantly attenuated by 3-methyladenine (3-MA), a blocker of autophagosome formation.	3-methyladenine	95-99	O-linked N-acetylglucosamine (GlcNAc) transferase	Rattus norvegicus	13-16
33298178-13	2020	Moreover, the antioxidant pathway Keap1/Nrf2 was also blocked when autophagy was inhibited by the autophagy inhibitor 3-MA.	3-methyladenine	118-122	kelch-like ECH-associated protein 1	Mus musculus	34-39
33298178-13	2020	Moreover, the antioxidant pathway Keap1/Nrf2 was also blocked when autophagy was inhibited by the autophagy inhibitor 3-MA.	3-methyladenine	118-122	nuclear factor, erythroid derived 2, like 2	Mus musculus	40-44
33332944-7	2020	Furthermore, the role of ERbeta in BGC autophagy was confirmed through treatment with rapamycin (RAPA) or 3-methyladenine (3-MA) in BGCs by cotransfection with si-ERbeta or oe-ERbeta in BGCs.	3-methyladenine	106-121	estrogen receptor 2	Bos taurus	25-31
33332944-7	2020	Furthermore, the role of ERbeta in BGC autophagy was confirmed through treatment with rapamycin (RAPA) or 3-methyladenine (3-MA) in BGCs by cotransfection with si-ERbeta or oe-ERbeta in BGCs.	3-methyladenine	123-127	estrogen receptor 2	Bos taurus	25-31
33332944-7	2020	Furthermore, the role of ERbeta in BGC autophagy was confirmed through treatment with rapamycin (RAPA) or 3-methyladenine (3-MA) in BGCs by cotransfection with si-ERbeta or oe-ERbeta in BGCs.	3-methyladenine	123-127	estrogen receptor 2	Bos taurus	163-169
32836151-5	2020	Additionally, autophagy inhibitor 3-MA decreased Beclin-1, LC3II/LC3I protein levels and increased p62 protein level.	3-methyladenine	34-38	beclin 1	Homo sapiens	49-57
32836151-5	2020	Additionally, autophagy inhibitor 3-MA decreased Beclin-1, LC3II/LC3I protein levels and increased p62 protein level.	3-methyladenine	34-38	nucleoporin 62	Homo sapiens	99-102
32836151-6	2020	Moreover, co-treatment with Cd and 3-MA could notably elevate Caspase-3, Cyt C, Bax, and Bak-1 mRNA levels, Caspase-3 and cleaved Caspase-3 protein levels, and cell apoptotic rate as well as cell damage, decreased mitochondrial membrane potential (MMP), Bcl-2 mRNA level and the ratio of Bcl-2 to Bax compared to treatment with Cd alone.	3-methyladenine	35-39	caspase 3	Homo sapiens	62-71
32836151-6	2020	Moreover, co-treatment with Cd and 3-MA could notably elevate Caspase-3, Cyt C, Bax, and Bak-1 mRNA levels, Caspase-3 and cleaved Caspase-3 protein levels, and cell apoptotic rate as well as cell damage, decreased mitochondrial membrane potential (MMP), Bcl-2 mRNA level and the ratio of Bcl-2 to Bax compared to treatment with Cd alone.	3-methyladenine	35-39	BCL2 associated X, apoptosis regulator	Homo sapiens	80-83
32836151-6	2020	Moreover, co-treatment with Cd and 3-MA could notably elevate Caspase-3, Cyt C, Bax, and Bak-1 mRNA levels, Caspase-3 and cleaved Caspase-3 protein levels, and cell apoptotic rate as well as cell damage, decreased mitochondrial membrane potential (MMP), Bcl-2 mRNA level and the ratio of Bcl-2 to Bax compared to treatment with Cd alone.	3-methyladenine	35-39	BCL2 antagonist/killer 1	Homo sapiens	89-94
32836151-6	2020	Moreover, co-treatment with Cd and 3-MA could notably elevate Caspase-3, Cyt C, Bax, and Bak-1 mRNA levels, Caspase-3 and cleaved Caspase-3 protein levels, and cell apoptotic rate as well as cell damage, decreased mitochondrial membrane potential (MMP), Bcl-2 mRNA level and the ratio of Bcl-2 to Bax compared to treatment with Cd alone.	3-methyladenine	35-39	caspase 3	Homo sapiens	108-117
32836151-6	2020	Moreover, co-treatment with Cd and 3-MA could notably elevate Caspase-3, Cyt C, Bax, and Bak-1 mRNA levels, Caspase-3 and cleaved Caspase-3 protein levels, and cell apoptotic rate as well as cell damage, decreased mitochondrial membrane potential (MMP), Bcl-2 mRNA level and the ratio of Bcl-2 to Bax compared to treatment with Cd alone.	3-methyladenine	35-39	caspase 3	Homo sapiens	108-117
32836151-6	2020	Moreover, co-treatment with Cd and 3-MA could notably elevate Caspase-3, Cyt C, Bax, and Bak-1 mRNA levels, Caspase-3 and cleaved Caspase-3 protein levels, and cell apoptotic rate as well as cell damage, decreased mitochondrial membrane potential (MMP), Bcl-2 mRNA level and the ratio of Bcl-2 to Bax compared to treatment with Cd alone.	3-methyladenine	35-39	BCL2 apoptosis regulator	Homo sapiens	254-259
32836151-6	2020	Moreover, co-treatment with Cd and 3-MA could notably elevate Caspase-3, Cyt C, Bax, and Bak-1 mRNA levels, Caspase-3 and cleaved Caspase-3 protein levels, and cell apoptotic rate as well as cell damage, decreased mitochondrial membrane potential (MMP), Bcl-2 mRNA level and the ratio of Bcl-2 to Bax compared to treatment with Cd alone.	3-methyladenine	35-39	BCL2 apoptosis regulator	Homo sapiens	288-293
32836151-6	2020	Moreover, co-treatment with Cd and 3-MA could notably elevate Caspase-3, Cyt C, Bax, and Bak-1 mRNA levels, Caspase-3 and cleaved Caspase-3 protein levels, and cell apoptotic rate as well as cell damage, decreased mitochondrial membrane potential (MMP), Bcl-2 mRNA level and the ratio of Bcl-2 to Bax compared to treatment with Cd alone.	3-methyladenine	35-39	BCL2 associated X, apoptosis regulator	Homo sapiens	297-300
33243748-13	2020	Blocking autophagy with 3-MA significantly increased DDP- induced apoptosis of SKOV3 cells with IL-17RA silencing, lowered the expression of Bcl-2 and enhanced Bax expression in the cells (P < 0.05).	3-methyladenine	24-28	interleukin 17 receptor A	Homo sapiens	96-103
33243748-13	2020	Blocking autophagy with 3-MA significantly increased DDP- induced apoptosis of SKOV3 cells with IL-17RA silencing, lowered the expression of Bcl-2 and enhanced Bax expression in the cells (P < 0.05).	3-methyladenine	24-28	BCL2 apoptosis regulator	Homo sapiens	141-146
33243748-13	2020	Blocking autophagy with 3-MA significantly increased DDP- induced apoptosis of SKOV3 cells with IL-17RA silencing, lowered the expression of Bcl-2 and enhanced Bax expression in the cells (P < 0.05).	3-methyladenine	24-28	BCL2 associated X, apoptosis regulator	Homo sapiens	160-163
33260158-5	2020	Autophagy inhibition using 3-methyladenine (3-MA) or Atg5-targeted siRNA decreased the Bax/Bcl-2 ratio, caspase-3 activation, and PARP cleavage and protected cells against ISO-induced apoptosis.	3-methyladenine	44-48	BCL2 associated X, apoptosis regulator	Homo sapiens	87-90
33260158-5	2020	Autophagy inhibition using 3-methyladenine (3-MA) or Atg5-targeted siRNA decreased the Bax/Bcl-2 ratio, caspase-3 activation, and PARP cleavage and protected cells against ISO-induced apoptosis.	3-methyladenine	44-48	BCL2 apoptosis regulator	Homo sapiens	91-96
33260158-5	2020	Autophagy inhibition using 3-methyladenine (3-MA) or Atg5-targeted siRNA decreased the Bax/Bcl-2 ratio, caspase-3 activation, and PARP cleavage and protected cells against ISO-induced apoptosis.	3-methyladenine	44-48	caspase 3	Homo sapiens	104-113
33260158-5	2020	Autophagy inhibition using 3-methyladenine (3-MA) or Atg5-targeted siRNA decreased the Bax/Bcl-2 ratio, caspase-3 activation, and PARP cleavage and protected cells against ISO-induced apoptosis.	3-methyladenine	44-48	collagen type XI alpha 2 chain	Homo sapiens	130-134
33237807-7	2021	Moreover, overexpression of FoxO3 prevented exacerbation of brain damage induced by 3-MA.	3-methyladenine	84-88	forkhead box O3	Mus musculus	28-33
33312358-12	2020	PI3K, p-AKT1, p-mTOR, p-p70S6K and caspase-3 were down-regulated by rapamycin and beta-ecdysterone, and up-regulated by 3-methyladenine in both the chondrocytes and the cartilage tissues.	3-methyladenine	120-135	AKT serine/threonine kinase 1	Rattus norvegicus	8-12
33312358-12	2020	PI3K, p-AKT1, p-mTOR, p-p70S6K and caspase-3 were down-regulated by rapamycin and beta-ecdysterone, and up-regulated by 3-methyladenine in both the chondrocytes and the cartilage tissues.	3-methyladenine	120-135	mechanistic target of rapamycin kinase	Rattus norvegicus	16-20
33312358-12	2020	PI3K, p-AKT1, p-mTOR, p-p70S6K and caspase-3 were down-regulated by rapamycin and beta-ecdysterone, and up-regulated by 3-methyladenine in both the chondrocytes and the cartilage tissues.	3-methyladenine	120-135	ribosomal protein S6 kinase B1	Rattus norvegicus	24-30
33312358-12	2020	PI3K, p-AKT1, p-mTOR, p-p70S6K and caspase-3 were down-regulated by rapamycin and beta-ecdysterone, and up-regulated by 3-methyladenine in both the chondrocytes and the cartilage tissues.	3-methyladenine	120-135	caspase 3	Rattus norvegicus	35-44
33204070-12	2020	Meanwhile, the cell protective effects of miR-200a against TP were reversed by autophagy inhibitor 3MA, indicating that autophagy plays an important role.	3-methyladenine	99-102	microRNA 200a	Mus musculus	42-50
33182520-5	2020	In addition, the relative protein expression of Bax and caspase-3 was significantly higher (p < 0.05), while that of Bcl-2 and Bcl-xl was decreased significantly (p < 0.05), in the NH4Cl + 3-Methyladenine (3-MA) group and the methionine (Met) + 3-MA group in comparison with the NH4Cl group.	3-methyladenine	189-204	apoptosis regulator BAX	Capra hircus	48-51
33182520-5	2020	In addition, the relative protein expression of Bax and caspase-3 was significantly higher (p < 0.05), while that of Bcl-2 and Bcl-xl was decreased significantly (p < 0.05), in the NH4Cl + 3-Methyladenine (3-MA) group and the methionine (Met) + 3-MA group in comparison with the NH4Cl group.	3-methyladenine	189-204	caspase-3	Capra hircus	56-65
33182520-5	2020	In addition, the relative protein expression of Bax and caspase-3 was significantly higher (p < 0.05), while that of Bcl-2 and Bcl-xl was decreased significantly (p < 0.05), in the NH4Cl + 3-Methyladenine (3-MA) group and the methionine (Met) + 3-MA group in comparison with the NH4Cl group.	3-methyladenine	189-204	apoptosis regulator Bcl-2	Capra hircus	117-122
33182520-5	2020	In addition, the relative protein expression of Bax and caspase-3 was significantly higher (p < 0.05), while that of Bcl-2 and Bcl-xl was decreased significantly (p < 0.05), in the NH4Cl + 3-Methyladenine (3-MA) group and the methionine (Met) + 3-MA group in comparison with the NH4Cl group.	3-methyladenine	206-210	apoptosis regulator BAX	Capra hircus	48-51
33182520-5	2020	In addition, the relative protein expression of Bax and caspase-3 was significantly higher (p < 0.05), while that of Bcl-2 and Bcl-xl was decreased significantly (p < 0.05), in the NH4Cl + 3-Methyladenine (3-MA) group and the methionine (Met) + 3-MA group in comparison with the NH4Cl group.	3-methyladenine	245-249	apoptosis regulator BAX	Capra hircus	48-51
33137133-5	2020	Moreover, the autophagy inhibitor 3-MA decreased IR-induced liver necrosis and markedly abrogated the rise in liver injury tests (AST/ALT).	3-methyladenine	34-38	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	130-133
33137133-5	2020	Moreover, the autophagy inhibitor 3-MA decreased IR-induced liver necrosis and markedly abrogated the rise in liver injury tests (AST/ALT).	3-methyladenine	34-38	glutamic pyruvic transaminase, soluble	Mus musculus	134-137
33313247-9	2020	Interestingly, similar results were observed for BNIP3 overexpression, which can be largely blocked by 3-MA, a well-defined inhibitor of autophagy.	3-methyladenine	103-107	BCL2 interacting protein 3	Homo sapiens	49-54
31931659-12	2020	Collectively, our results identify ROS as central inducers of MTORC2 activation during chronic autophagy, which in turn fuels senescence activation and myofibroblast differentiation in distinct cellular subpopulations.Abbreviations: 3-MA: 3-methyladenine; ACTA2: actin, alpha 2, smooth muscle, aorta; AKT1: AKT serine/threonine kinase 1; p-AKT1: AKT1 Ser473 phosphorylation; t-AKT1: total AKT serine/threonine kinase 1; ATG4A: autophagy related 4A cysteine peptidase; ATG7: autophagy gene 7; C12FDG: 5-dodecanoylaminofluorescein Di-beta-D-Galactopyranoside; CDKN1A: cyclin dependent kinase inhibitor 1A; CDKN2A: cyclin dependent kinase inhibitor 2A; Ctl: control; DAPI: 4",6-diamidino-2-phenylindole, dilactate; ECM: extracellular matrix; GSH: L-glutathione reduced; H2O2: hydrogen peroxide; HLF: adult human lung fibroblasts; Ho: Hoechst 33342 (2"-[4-ethoxyphenyl]-5-[4-methyl-1-piperazinyl]-2.5"-bi-1H-benzimidazole); HSC: hepatic stellate cells; LY: LY294002; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MTORC1/2: mechanistic target of rapamycin kinase complex 1/2; N: normal growth medium; NAC: N-acetyl-L-cysteine; PBS: phosphate-buffered saline; PDGFA: platelet derived growth factor subunit A; PRKCA/PKCalpha: protein kinase C alpha; PtdIns3K: class III phosphatidylinositol 3-kinase; PTEN: phosphatase and tensin homolog; R: rapamycin; RICTOR: RPTOR independent companion of MTOR complex 2; ROS: reactive oxygen species; RPTOR: regulatory associated protein of MTOR complex 1; SA-GLB1/beta-gal: senescence-associated galactosidase beta 1; SGK1: serum/glucocorticoid regulated kinase 1; shRNA: short hairpin RNA; siCtl: control siRNA; siRNA: small interfering RNA; SQSTM1: sequestosome 1; SS: serum-free (serum starvation) medium; TP53: tumor protein p53; TUBA: tubulin alpha; V: vehicle.	3-methyladenine	239-254	mechanistic target of rapamycin kinase	Homo sapiens	62-66
32086669-9	2020	Further, pre-treatment with the selective autophagy inhibitor 3-methyladenine abolished the effects of FAM134B on ER stress and neuronal apoptosis.	3-methyladenine	62-77	reticulophagy regulator 1	Homo sapiens	103-110
32382831-8	2020	Under 3-MA treatment, the MFI expressed of p62 in B cells weakened.	3-methyladenine	6-10	sequestosome 1	Homo sapiens	43-46
32239675-6	2020	Autophagy inhibitor 3-MA pretreatment reversed the anti-senescent and protective effects on the mitochondrial function of HO-1, which promoted the degradation of the extracellular matrix (ECM) in the intervertebral disc.	3-methyladenine	20-24	heme oxygenase 1	Homo sapiens	122-126
33043596-9	2020	Calhex231 and 3-Methyladenine (a specific inhibitor of autophagy) attenuated both autophagy and NLRP3 inflammasome activation; however, the caspase-1 inhibitor Z-YVAD-FMK did not.	3-methyladenine	14-29	NLR family, pyrin domain containing 3	Rattus norvegicus	96-101
33010605-8	2020	Inhibiting miR-193b induced the pro-autophagic, cytostatic, and pro-apoptotic effects reduced by 3-MA in HTR8 cells upon HG treatment.	3-methyladenine	97-101	microRNA 193b	Homo sapiens	11-19
33010382-9	2020	Furthermore, 3MA reversed both the nicotine-induced decrease in Bcl-2 and the increase in Bax in both groups.	3-methyladenine	13-16	BCL2 apoptosis regulator	Homo sapiens	64-69
33010382-9	2020	Furthermore, 3MA reversed both the nicotine-induced decrease in Bcl-2 and the increase in Bax in both groups.	3-methyladenine	13-16	BCL2 associated X, apoptosis regulator	Homo sapiens	90-93
33193083-10	2020	The autophagy inhibitor 3-methyladenine restored the reduced UCP1 protein level and thermogenic capacity caused by inhibiting FOXC2-AS1.	3-methyladenine	24-39	uncoupling protein 1	Homo sapiens	61-65
33193083-10	2020	The autophagy inhibitor 3-methyladenine restored the reduced UCP1 protein level and thermogenic capacity caused by inhibiting FOXC2-AS1.	3-methyladenine	24-39	forkhead box C2	Homo sapiens	126-131
33193083-10	2020	The autophagy inhibitor 3-methyladenine restored the reduced UCP1 protein level and thermogenic capacity caused by inhibiting FOXC2-AS1.	3-methyladenine	24-39	prostaglandin D2 receptor	Homo sapiens	132-135
33145365-7	2020	Furthermore, our data displayed that inhibition of autophagy either with 3-MA or CQ can partially reverse the decrease of migration and invasion induced by YAP and TAZ knockdown in RA-FLS.	3-methyladenine	73-77	Yes1 associated transcriptional regulator	Homo sapiens	156-159
33079330-7	2021	Furthermore, we showed that pretreatment with rapamycin exacerbated H2O2-mediated cytotoxicity and caspase-3 activation but that 3-MA or siRNAs specific for Beclin 1 and Atg7 genes ameliorated H2O2-mediated GC apoptosis.	3-methyladenine	129-133	beclin 1	Homo sapiens	157-165
33177988-11	2020	We identified that the probable clearance effect of hepcidin on alpha-syn was mediated by the autophagy pathway using pretreatment with autophagy inhibitors (3-MA and CQ) and detection of autophagy protein markers (LC3II/I and p62).	3-methyladenine	158-162	hepcidin antimicrobial peptide	Homo sapiens	52-60
33177988-11	2020	We identified that the probable clearance effect of hepcidin on alpha-syn was mediated by the autophagy pathway using pretreatment with autophagy inhibitors (3-MA and CQ) and detection of autophagy protein markers (LC3II/I and p62).	3-methyladenine	158-162	synuclein alpha	Homo sapiens	64-73
33178023-8	2020	Among them, 3-methyladenine, SBI-0206965, Chloroquine, and Bafilomycin A1 triggered BAX- and/or BAK-dependent cytotoxicity and caspase activation.	3-methyladenine	12-27	BCL2 associated X, apoptosis regulator	Homo sapiens	84-87
33178023-8	2020	Among them, 3-methyladenine, SBI-0206965, Chloroquine, and Bafilomycin A1 triggered BAX- and/or BAK-dependent cytotoxicity and caspase activation.	3-methyladenine	12-27	BCL2 antagonist/killer 1	Homo sapiens	96-99
33178023-11	2020	Autophagy-deficient Fip200-/- MEFs displayed an increased sensitivity to activate caspases and to undergo cell death in response to 3-methyladenine.	3-methyladenine	132-147	RB1 inducible coiled-coil 1	Homo sapiens	20-26
33178023-13	2020	This genotoxicity was observed at 10 mM 3-methyladenine, the usual concentration to inhibit autophagy and was maximized in Fip200-/- MEFs.	3-methyladenine	40-55	RB1 inducible coiled-coil 1	Homo sapiens	123-129
33178622-5	2020	Inhibition of autophagy with 3-methyladenine (3-MA) weakened the inhibitory effect of LL-37 on the number of intracellular P. gingivalis.	3-methyladenine	29-44	cathelicidin antimicrobial peptide	Homo sapiens	86-91
33178622-5	2020	Inhibition of autophagy with 3-methyladenine (3-MA) weakened the inhibitory effect of LL-37 on the number of intracellular P. gingivalis.	3-methyladenine	46-50	cathelicidin antimicrobial peptide	Homo sapiens	86-91
32798557-11	2020	After treatment with 3MA, an inhibitor of mTOR/p70S6K signaling pathway, the protective effects of Rapamycin on CIAKI were weakened.	3-methyladenine	21-24	mechanistic target of rapamycin kinase	Rattus norvegicus	42-46
32798557-11	2020	After treatment with 3MA, an inhibitor of mTOR/p70S6K signaling pathway, the protective effects of Rapamycin on CIAKI were weakened.	3-methyladenine	21-24	ribosomal protein S6 kinase B1	Rattus norvegicus	47-53
33116622-6	2020	Functional experiments showed that 3-MA removed the inhibitory effect of GAS8-AS1 in OC cells.	3-methyladenine	35-39	growth arrest specific 8	Homo sapiens	73-77
33116622-6	2020	Functional experiments showed that 3-MA removed the inhibitory effect of GAS8-AS1 in OC cells.	3-methyladenine	35-39	prostaglandin D2 receptor	Homo sapiens	78-81
33116499-5	2020	In addition, increasing or decreasing the autophagosomes number by rapamycin or 3-methyladenine (3-MA) will result in augmentation or attenuation of Arg1.	3-methyladenine	80-95	arginase 1	Homo sapiens	149-153
33116499-5	2020	In addition, increasing or decreasing the autophagosomes number by rapamycin or 3-methyladenine (3-MA) will result in augmentation or attenuation of Arg1.	3-methyladenine	97-101	arginase 1	Homo sapiens	149-153
31965901-8	2020	These results revealed the essential role of autophagy in endothelial cell integrity and revealed that the disruption of endothelial autophagy could lead to significant pathological IL6-dependent EndMT and organ fibrosis.Abbreviations: 3-MA: 3-methyladenine; ATG5: autophagy related 5; EndMT: endothelial-to-mesenchymal transition; HES: hematoxylin and eosin stain; HFD: high-fat diet; HMVECs: human microvascular endothelial cells; IFNG: interferon gamma; IL6: interleukin 6; MTS: Masson"s trichrome staining; NFD: normal-fat diet; siRNA: small interfering RNA; SMAD3: SMAD family member 3; TGFB: transforming growth factor beta; TNF: tumor necrosis factor; VEGFA: vascular endothelial growth factor A.	3-methyladenine	242-257	interleukin 6	Homo sapiens	182-185
31983282-7	2020	Taken together, our data suggest that PRKDC-mediated phosphorylation of PRKAG1 primes AMPK complex to the lysosomal activation by STK11 in cancer cells thereby linking DNA damage response to autophagy and cellular metabolism.Abbreviations: AXIN1: axin 1; 3-MA: 3-methyladenine; 5-FU: 5-fluorouracil; AA mutant: double alanine mutant (S192A, T284A) of PRKAG1; ACACA: acetyl-CoA carboxylase alpha; AICAR: 5-Aminoimidazole-4-carboxamide ribonucleotide; AMPK: AMP-activated protein kinase; ATG: autophagy-related; ATM: ataxia telangiectasia mutated; ATR: ATM serine/threonine kinase; AV: autophagic vacuole; AVd: degradative autophagic vacuole; AVi: initial autophagic vacuole; BECN1: beclin 1; BSA: bovine serum albumin; CBS: cystathionine beta-synthase; CDK7: cyclin dependent kinase 7; CDKN1A: cyclin dependent kinase inhibitor 1A; EGFP: enhanced green fluorescent protein; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GST: glutathione S transferase; H2AX/H2AFX: H2A.X variant histone; HBSS: Hanks balanced salt solution; IP: immunopurification; IR: ionizing radiation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAP3K9: mitogen-activated protein kinase kinase kinase 9; mRFP: monomeric red fluorescent protein; mCh: mCherry; MCM7: minichromosome maintenance complex component 7; MTORC1: mechanistic target of rapamycin kinase complex 1; NHEJ: non-homologous end joining; NRBP2: nuclear receptor binding protein 2; NTC: non-targeting control; NUAK1: NUAK family kinase 1; PBS: phosphate-buffered saline; PIK3AP1: phosphoinositide-3-kinase adaptor protein 1; PIK3CA: phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit alpha; PIKK: phosphatidylinositol 3-kinase-related kinase; PRKAA: protein kinase AMP-activated catalytic subunit alpha; PRKAB: protein kinase AMP-activated non-catalytic subunit beta; PRKAG: protein kinase AMP-activated non-catalytic subunit gamma; PRKDC: protein kinase, DNA-activated, catalytic subunit; RLuc: Renilla luciferase; RPS6KB1: ribosomal protein S6 kinase B1; SQSTM1: sequestosome 1; STK11/LKB1: serine/threonine kinase 11; TP53: tumor protein p53; TSKS: testis specific serine kinase substrate; ULK1: unc-51 like autophagy activating kinase 1; WIPI2: WD repeat domain, phosphoinositide interacting 2; WT: wild type.	3-methyladenine	261-276	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	38-43
31983282-7	2020	Taken together, our data suggest that PRKDC-mediated phosphorylation of PRKAG1 primes AMPK complex to the lysosomal activation by STK11 in cancer cells thereby linking DNA damage response to autophagy and cellular metabolism.Abbreviations: AXIN1: axin 1; 3-MA: 3-methyladenine; 5-FU: 5-fluorouracil; AA mutant: double alanine mutant (S192A, T284A) of PRKAG1; ACACA: acetyl-CoA carboxylase alpha; AICAR: 5-Aminoimidazole-4-carboxamide ribonucleotide; AMPK: AMP-activated protein kinase; ATG: autophagy-related; ATM: ataxia telangiectasia mutated; ATR: ATM serine/threonine kinase; AV: autophagic vacuole; AVd: degradative autophagic vacuole; AVi: initial autophagic vacuole; BECN1: beclin 1; BSA: bovine serum albumin; CBS: cystathionine beta-synthase; CDK7: cyclin dependent kinase 7; CDKN1A: cyclin dependent kinase inhibitor 1A; EGFP: enhanced green fluorescent protein; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GST: glutathione S transferase; H2AX/H2AFX: H2A.X variant histone; HBSS: Hanks balanced salt solution; IP: immunopurification; IR: ionizing radiation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAP3K9: mitogen-activated protein kinase kinase kinase 9; mRFP: monomeric red fluorescent protein; mCh: mCherry; MCM7: minichromosome maintenance complex component 7; MTORC1: mechanistic target of rapamycin kinase complex 1; NHEJ: non-homologous end joining; NRBP2: nuclear receptor binding protein 2; NTC: non-targeting control; NUAK1: NUAK family kinase 1; PBS: phosphate-buffered saline; PIK3AP1: phosphoinositide-3-kinase adaptor protein 1; PIK3CA: phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit alpha; PIKK: phosphatidylinositol 3-kinase-related kinase; PRKAA: protein kinase AMP-activated catalytic subunit alpha; PRKAB: protein kinase AMP-activated non-catalytic subunit beta; PRKAG: protein kinase AMP-activated non-catalytic subunit gamma; PRKDC: protein kinase, DNA-activated, catalytic subunit; RLuc: Renilla luciferase; RPS6KB1: ribosomal protein S6 kinase B1; SQSTM1: sequestosome 1; STK11/LKB1: serine/threonine kinase 11; TP53: tumor protein p53; TSKS: testis specific serine kinase substrate; ULK1: unc-51 like autophagy activating kinase 1; WIPI2: WD repeat domain, phosphoinositide interacting 2; WT: wild type.	3-methyladenine	261-276	protein kinase AMP-activated non-catalytic subunit gamma 1	Homo sapiens	72-78
31983282-7	2020	Taken together, our data suggest that PRKDC-mediated phosphorylation of PRKAG1 primes AMPK complex to the lysosomal activation by STK11 in cancer cells thereby linking DNA damage response to autophagy and cellular metabolism.Abbreviations: AXIN1: axin 1; 3-MA: 3-methyladenine; 5-FU: 5-fluorouracil; AA mutant: double alanine mutant (S192A, T284A) of PRKAG1; ACACA: acetyl-CoA carboxylase alpha; AICAR: 5-Aminoimidazole-4-carboxamide ribonucleotide; AMPK: AMP-activated protein kinase; ATG: autophagy-related; ATM: ataxia telangiectasia mutated; ATR: ATM serine/threonine kinase; AV: autophagic vacuole; AVd: degradative autophagic vacuole; AVi: initial autophagic vacuole; BECN1: beclin 1; BSA: bovine serum albumin; CBS: cystathionine beta-synthase; CDK7: cyclin dependent kinase 7; CDKN1A: cyclin dependent kinase inhibitor 1A; EGFP: enhanced green fluorescent protein; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GST: glutathione S transferase; H2AX/H2AFX: H2A.X variant histone; HBSS: Hanks balanced salt solution; IP: immunopurification; IR: ionizing radiation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAP3K9: mitogen-activated protein kinase kinase kinase 9; mRFP: monomeric red fluorescent protein; mCh: mCherry; MCM7: minichromosome maintenance complex component 7; MTORC1: mechanistic target of rapamycin kinase complex 1; NHEJ: non-homologous end joining; NRBP2: nuclear receptor binding protein 2; NTC: non-targeting control; NUAK1: NUAK family kinase 1; PBS: phosphate-buffered saline; PIK3AP1: phosphoinositide-3-kinase adaptor protein 1; PIK3CA: phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit alpha; PIKK: phosphatidylinositol 3-kinase-related kinase; PRKAA: protein kinase AMP-activated catalytic subunit alpha; PRKAB: protein kinase AMP-activated non-catalytic subunit beta; PRKAG: protein kinase AMP-activated non-catalytic subunit gamma; PRKDC: protein kinase, DNA-activated, catalytic subunit; RLuc: Renilla luciferase; RPS6KB1: ribosomal protein S6 kinase B1; SQSTM1: sequestosome 1; STK11/LKB1: serine/threonine kinase 11; TP53: tumor protein p53; TSKS: testis specific serine kinase substrate; ULK1: unc-51 like autophagy activating kinase 1; WIPI2: WD repeat domain, phosphoinositide interacting 2; WT: wild type.	3-methyladenine	261-276	serine/threonine kinase 11	Homo sapiens	130-135
31986961-10	2020	In summary, our study determined that ULK1 may represent a new therapeutic target for HCC and that targeting ULK1 in combination with sorafenib treatment may serve as a promising interventional strategy for treating HCC.Abbreviations: 3MA: 3-methyladenine; ADV: AutoDock Vina; ATP: adenosine triphosphate; EdU: 5-ethynyl-2"-deoxyuridine; ESI: electrospray ionization; HCC: hepatocellular carcinoma; IC50: half maximal inhibitory concentration; KD: kinase domain; q.o.d., every other day; SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis; SPR, surface plasmon resonance.	3-methyladenine	240-255	unc-51 like kinase 1	Mus musculus	109-113
32955950-8	2020	Interestingly, after coculture of BW373U86 and PI3K inhibitor (3-methyladenine), the protein expression levels of p-Akt in cardiomyocytes were markedly increased in comparison with those in the BW373U86 group (p < 0.05).	3-methyladenine	63-78	AKT serine/threonine kinase 1	Rattus norvegicus	116-119
32552228-0	2020	3-Methyladenine Alleviates Experimental Subretinal Fibrosis by Inhibiting Macrophages and M2 Polarization Through the PI3K/Akt Pathway.	3-methyladenine	0-15	thymoma viral proto-oncogene 1	Mus musculus	123-126
32552228-1	2020	Purpose: To explore the effects of 3-methyladenine (3-MA), a selective inhibitor of phosphatidylinositol-3-kinase (PI3K), on experimental subretinal fibrosis (SRF) in mice.	3-methyladenine	35-50	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	84-113
32552228-1	2020	Purpose: To explore the effects of 3-methyladenine (3-MA), a selective inhibitor of phosphatidylinositol-3-kinase (PI3K), on experimental subretinal fibrosis (SRF) in mice.	3-methyladenine	52-56	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	84-113
32552228-11	2020	Mechanistically, we proved that 3-MA inhibits macrophage M2 polarization by suppressing PI3K/Akt signal pathway rather than the PI3K-autophagy-related signal pathway.	3-methyladenine	32-36	thymoma viral proto-oncogene 1	Mus musculus	93-96
32552228-12	2020	Conclusions: 3-MA exerts antifibrotic effects on experimental SRF by targeting circulating and local macrophages and M2 polarization, through PI3K/Akt signal pathway.	3-methyladenine	13-17	thymoma viral proto-oncogene 1	Mus musculus	147-150
32949703-12	2020	The effects by THP on lung injury, PI3K/AKT/mTOR signaling and autophagy were also observed after treatment with 3-MA, an autophagy inhibitor, whereas were blocked by combinational treatment with RAPA, an autophagy inducer.	3-methyladenine	113-117	AKT serine/threonine kinase 1	Rattus norvegicus	40-43
32949703-12	2020	The effects by THP on lung injury, PI3K/AKT/mTOR signaling and autophagy were also observed after treatment with 3-MA, an autophagy inhibitor, whereas were blocked by combinational treatment with RAPA, an autophagy inducer.	3-methyladenine	113-117	mechanistic target of rapamycin kinase	Rattus norvegicus	44-48
32998359-9	2020	Furthermore, the autophagy inhibitor 3-methyladenine (3-MA) was used to treat Rin-m5f cells, confirming that the MKP-5 overexpression suppressed apoptosis, dysfunction, inflammatory response, and oxidative stress induced by PA via improving autophagic signaling.	3-methyladenine	37-52	dual specificity phosphatase 10	Rattus norvegicus	113-118
32998359-9	2020	Furthermore, the autophagy inhibitor 3-methyladenine (3-MA) was used to treat Rin-m5f cells, confirming that the MKP-5 overexpression suppressed apoptosis, dysfunction, inflammatory response, and oxidative stress induced by PA via improving autophagic signaling.	3-methyladenine	54-58	dual specificity phosphatase 10	Rattus norvegicus	113-118
32946432-6	2020	Blocking autophagy with 3-methyladenine increased the sensitivity of chemotherapy confirmed by flow cytometry and microtubule-associated protein 1A/1B - light chain 3 punctate assay.	3-methyladenine	24-39	microtubule associated protein 1A	Homo sapiens	114-150
32682786-7	2020	Furthermore, miR-122-5p inhibitor-mediated pro-autophagic, anti-oxidant and anti-apoptotic effects in rat AFs were partially suppressed by 3-methyladenine, SIRT6 small interfering RNA (siRNA) and ELA siRNA, which were linked with the downregulation in the protein levels of LC3-II, beclin-1, and ACE2 and the upregulation of p62 expression and bax/bcl-2 ratio.	3-methyladenine	139-154	microRNA 1225	Homo sapiens	13-23
32819559-8	2020	Then, an activator of PI3K weakened the effect of UHRF1 silencing on cell proliferation, autophagy, apoptosis of IL-1beta-induced chondrocytes, and the cell autophagy special inhibitor 3-methyladenine (3-MA) also showed a same impact on UHRF1, hence suggesting that knockdown of UHRF1 enhances cell autophagy to protect chondrocytes from apoptosis in OA through PI3K/AKT/mTOR signaling pathway.	3-methyladenine	202-206	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	50-55
32982695-8	2020	Our results also revealed that JQ1 treatment activated autophagy and restored autophagic flux, while the positive effects of JQ1 were abrogated by autophagy inhibitor 3-MA intervention, indicating that autophagy plays a crucial role in therapeutic effects Brd4 induced by inhibition of the functional recovery SCI.	3-methyladenine	167-171	bromodomain containing 4	Mus musculus	256-260
32599516-9	2020	Following further treatment by 3-Methyladenine, Beclin-1 protein expression was decreased (P < 0.05) compared with the LIPUS plus lipopolysaccharide group, but LC3-II protein expression was not.	3-methyladenine	31-46	beclin 1	Homo sapiens	48-56
32691991-8	2020	Co-administration of 3-MA with Puerarin 6""-O-xyloside obviously augmented these effects including inhibited protein expression of p-PI3K, p-AKT, and p-mTOR, and inhibited proliferation, promoted apoptosis, and decreased stemness.	3-methyladenine	21-25	AKT serine/threonine kinase 1	Homo sapiens	141-144
32691991-8	2020	Co-administration of 3-MA with Puerarin 6""-O-xyloside obviously augmented these effects including inhibited protein expression of p-PI3K, p-AKT, and p-mTOR, and inhibited proliferation, promoted apoptosis, and decreased stemness.	3-methyladenine	21-25	mechanistic target of rapamycin kinase	Homo sapiens	152-156
32882870-14	2020	Whereas, 3-methyladenine/chloroquine weakened FKB+doxorubicin-induced apoptosis (decreased DNA fragmentation/caspase-3).	3-methyladenine	9-24	caspase 3	Mus musculus	109-118
32314842-7	2020	3-MA also had a promotion effect on irradiation-mediated growth inhibition possibly by depressing PI3K and on curcumin/GLUT-1 AS-ODN-mediated growth inhibition potentially by regulating autophagic events.	3-methyladenine	0-4	solute carrier family 2 member 1	Homo sapiens	119-125
32090627-8	2020	To examine the effect of autophagy inhibitor (3-methyladenine (3-MA)) on miR-146a-regulated apoptotic protein expression, 30 rats were further divided into the sham, ICH, miR-146a agomir, 3-MA, and miR-146a + 3-MA groups.	3-methyladenine	46-61	microRNA 146a	Rattus norvegicus	73-81
32090627-8	2020	To examine the effect of autophagy inhibitor (3-methyladenine (3-MA)) on miR-146a-regulated apoptotic protein expression, 30 rats were further divided into the sham, ICH, miR-146a agomir, 3-MA, and miR-146a + 3-MA groups.	3-methyladenine	63-67	microRNA 146a	Rattus norvegicus	73-81
33140921-7	2020	However, the inhibition of autophagy by 3-MA abolished the protective effects of TLR9 deletion on DOX-induced cardiotoxicity.	3-methyladenine	40-44	toll like receptor 9	Homo sapiens	81-85
32632609-11	2020	Moreover, CRNDE silencing promoted autophagy and the autophagy inhibitor 3-methyladenine counteracted the neuroprotective effect of CRNDE silencing on HI-induced neuronal injury both in vivo and in vitro.	3-methyladenine	73-88	colorectal neoplasia differentially expressed	Rattus norvegicus	132-137
32688118-9	2020	in vivo experiments demonstrated that Baicalin inhibited OVA-induced allergic nasal symptoms and the activation of autophagy pathway, which was the same as the regulation of 3-MA, while Rapa could weaken the effects of H-baicalin.	3-methyladenine	174-178	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	57-60
32913552-8	2020	In addition, pretreatment with 3-methyladenine, an inhibitor of autophagy, aggravated apoptosis and abolished renoprotection by HO-1, suggesting that the anti-apoptotic effect of HO-1 in Pb-induced nephrotoxicity is dependent on enhanced autophagy.	3-methyladenine	31-46	heme oxygenase 1	Homo sapiens	128-132
32913552-8	2020	In addition, pretreatment with 3-methyladenine, an inhibitor of autophagy, aggravated apoptosis and abolished renoprotection by HO-1, suggesting that the anti-apoptotic effect of HO-1 in Pb-induced nephrotoxicity is dependent on enhanced autophagy.	3-methyladenine	31-46	heme oxygenase 1	Homo sapiens	179-183
32524997-7	2020	Autophagy, negatively regulated by ERalpha, positively controls AIF-mediated apoptosis, as evidenced by the preventive effect of autophagy inhibitor 3-MA and siRNA targeting LC3, on the nuclear translocation of AIF and cell death induced by silibinin co-treatment with or without MPP.	3-methyladenine	149-153	estrogen receptor 1	Homo sapiens	35-42
32524997-7	2020	Autophagy, negatively regulated by ERalpha, positively controls AIF-mediated apoptosis, as evidenced by the preventive effect of autophagy inhibitor 3-MA and siRNA targeting LC3, on the nuclear translocation of AIF and cell death induced by silibinin co-treatment with or without MPP.	3-methyladenine	149-153	apoptosis inducing factor mitochondria associated 1	Homo sapiens	64-67
32524997-7	2020	Autophagy, negatively regulated by ERalpha, positively controls AIF-mediated apoptosis, as evidenced by the preventive effect of autophagy inhibitor 3-MA and siRNA targeting LC3, on the nuclear translocation of AIF and cell death induced by silibinin co-treatment with or without MPP.	3-methyladenine	149-153	apoptosis inducing factor mitochondria associated 1	Homo sapiens	211-214
32913514-7	2020	The autophagy inhibitor 3-MA or silencing ATG7 rescued the apoptosis by knocking down ESR2 via activation of the MAPK signaling pathway in AGS cells, leading to increased apoptosis.	3-methyladenine	24-28	estrogen receptor 2	Homo sapiens	86-90
32792582-10	2020	Oocyte maturation under 3MA-41  C reduced mRNA abundance for genes related to energy metabolism (MTIF3), heat shock response (HSF1), and oocyte maturation (HAS2 and GREM1).	3-methyladenine	24-27	mitochondrial translational initiation factor 3	Bos taurus	97-102
32792582-10	2020	Oocyte maturation under 3MA-41  C reduced mRNA abundance for genes related to energy metabolism (MTIF3), heat shock response (HSF1), and oocyte maturation (HAS2 and GREM1).	3-methyladenine	24-27	heat shock transcription factor 1	Bos taurus	126-130
32792582-10	2020	Oocyte maturation under 3MA-41  C reduced mRNA abundance for genes related to energy metabolism (MTIF3), heat shock response (HSF1), and oocyte maturation (HAS2 and GREM1).	3-methyladenine	24-27	hyaluronan synthase 2	Bos taurus	156-160
32792582-10	2020	Oocyte maturation under 3MA-41  C reduced mRNA abundance for genes related to energy metabolism (MTIF3), heat shock response (HSF1), and oocyte maturation (HAS2 and GREM1).	3-methyladenine	24-27	gremlin 1, DAN family BMP antagonist	Bos taurus	165-170
33505579-6	2020	The inhibitory effects of fucoidan on NLRP3 inflammasome were enhanced by autophagy activator rapamycin (Rapa) and alleviated by autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	149-164	NLR family pyrin domain containing 3	Homo sapiens	38-43
33505579-6	2020	The inhibitory effects of fucoidan on NLRP3 inflammasome were enhanced by autophagy activator rapamycin (Rapa) and alleviated by autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	166-170	NLR family pyrin domain containing 3	Homo sapiens	38-43
32638014-9	2020	In addition, the inhibitory effects of ISL on TGF-beta1-induced fibrogenic features in MRC-5 cells were enhanced by pretreatment with autophagy activator Rapmycin and PI3K/AKT inhibitor LY294002 and reversed by autophagy inhibitor 3-methyladenine and PI3K/AKT activator IGF-1.	3-methyladenine	231-246	transforming growth factor beta 1	Homo sapiens	46-55
32774163-9	2020	When tanespimycin was combined with autophage inhibitor 3-MA, alpha-tubulin acetylation elevation was apparently, but LC3B-II was attenuated.	3-methyladenine	56-60	tubulin alpha 1b	Homo sapiens	62-75
32774163-9	2020	When tanespimycin was combined with autophage inhibitor 3-MA, alpha-tubulin acetylation elevation was apparently, but LC3B-II was attenuated.	3-methyladenine	56-60	microtubule associated protein 1 light chain 3 beta	Homo sapiens	118-122
32802407-6	2020	Irradiation increased the nuclear translocation of BECN1, and this process was inhibited by 3-MA.	3-methyladenine	92-96	beclin 1	Homo sapiens	51-56
32627938-7	2020	Meanwhile, autophagy inhibition by 3-methyladenine (3-MA) abrogated the effect of miR-33a mimics on proliferation and apoptosis of H2 O2 -treated HCC cells.	3-methyladenine	35-50	microRNA 33a	Homo sapiens	82-89
32627938-7	2020	Meanwhile, autophagy inhibition by 3-methyladenine (3-MA) abrogated the effect of miR-33a mimics on proliferation and apoptosis of H2 O2 -treated HCC cells.	3-methyladenine	52-56	microRNA 33a	Homo sapiens	82-89
32544529-7	2020	These are reversed after beta-arrestin1 overexpression (beta-arrestin1-OV) or treatment with 3-MA, an autophagy inhibitor.	3-methyladenine	93-97	arrestin beta 1	Homo sapiens	25-39
32626921-6	2020	Inhibition of autophagy using autophagy inhibitors 3-methyladenine and chloroquine upregulated the expression of DR5 and enhanced TRAIL-induced apoptosis, as confirmed by the increase of pro-apoptotic proteins caspase-8 and caspase-3.	3-methyladenine	51-66	TNF receptor superfamily member 10b	Homo sapiens	113-116
32626921-6	2020	Inhibition of autophagy using autophagy inhibitors 3-methyladenine and chloroquine upregulated the expression of DR5 and enhanced TRAIL-induced apoptosis, as confirmed by the increase of pro-apoptotic proteins caspase-8 and caspase-3.	3-methyladenine	51-66	TNF superfamily member 10	Homo sapiens	130-135
32626921-6	2020	Inhibition of autophagy using autophagy inhibitors 3-methyladenine and chloroquine upregulated the expression of DR5 and enhanced TRAIL-induced apoptosis, as confirmed by the increase of pro-apoptotic proteins caspase-8 and caspase-3.	3-methyladenine	51-66	caspase 8	Homo sapiens	210-219
32626921-6	2020	Inhibition of autophagy using autophagy inhibitors 3-methyladenine and chloroquine upregulated the expression of DR5 and enhanced TRAIL-induced apoptosis, as confirmed by the increase of pro-apoptotic proteins caspase-8 and caspase-3.	3-methyladenine	51-66	caspase 3	Homo sapiens	224-233
32648659-8	2020	Furthermore, inhibition with the autophagy inhibitor 3-methyladenine (3-MA) offset the aggravating effect of aldosterone-induced autophagy in the MD1-KO mice and cells both in vivo and in vitro.	3-methyladenine	53-68	lymphocyte antigen 86	Mus musculus	146-149
32648659-8	2020	Furthermore, inhibition with the autophagy inhibitor 3-methyladenine (3-MA) offset the aggravating effect of aldosterone-induced autophagy in the MD1-KO mice and cells both in vivo and in vitro.	3-methyladenine	70-74	lymphocyte antigen 86	Mus musculus	146-149
32944332-8	2020	Moreover, the inhibition of WWC3 gene knockout was weakened by 3-methyladenine (3-MA), an autophagy inhibitor.	3-methyladenine	63-78	WWC family member 3	Homo sapiens	28-32
32944332-8	2020	Moreover, the inhibition of WWC3 gene knockout was weakened by 3-methyladenine (3-MA), an autophagy inhibitor.	3-methyladenine	80-84	WWC family member 3	Homo sapiens	28-32
32698821-7	2020	EA-mediated improvements in insulin resistance, mitochondrial dysfunction, and endoplasmic reticulum (ER) stress in PCOS-like rats were counteracted by 3-MA pretreatment.	3-methyladenine	152-156	insulin	Homo sapiens	28-35
31715238-7	2020	Furthermore, it showed that NRF2 expression is restored in the presence of 3-methyladenine and Baficomycin-A1 establishing role of autophagy in modulation of NRF2 through p62.	3-methyladenine	75-90	NFE2 like bZIP transcription factor 2	Homo sapiens	28-32
31715238-7	2020	Furthermore, it showed that NRF2 expression is restored in the presence of 3-methyladenine and Baficomycin-A1 establishing role of autophagy in modulation of NRF2 through p62.	3-methyladenine	75-90	nucleoporin 62	Homo sapiens	171-174
32348837-10	2020	Furthermore, when the autophagy inhibitor 3-methyladenine (3-MA) was added, it exerted similar inhibition effects like CST, but didn"t augment the protective role of CST on Ang II-induced VSMC autophagy and proliferation.	3-methyladenine	42-57	cortistatin	Rattus norvegicus	119-122
32348837-10	2020	Furthermore, when the autophagy inhibitor 3-methyladenine (3-MA) was added, it exerted similar inhibition effects like CST, but didn"t augment the protective role of CST on Ang II-induced VSMC autophagy and proliferation.	3-methyladenine	59-63	cortistatin	Rattus norvegicus	119-122
32061152-4	2020	We used 3-methyladenine (3-MA) and ABT-737 to suppress the expression of phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) and B cell leukemia/lymphoma 2 (Bcl-2), two critical initiators of autophagy, and detected and evaluated the autophagy in NR8383 cells with or without silica dust exposure.	3-methyladenine	8-23	phosphatidylinositol 3-kinase catalytic subunit type 3	Mus musculus	73-127
32061152-4	2020	We used 3-methyladenine (3-MA) and ABT-737 to suppress the expression of phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) and B cell leukemia/lymphoma 2 (Bcl-2), two critical initiators of autophagy, and detected and evaluated the autophagy in NR8383 cells with or without silica dust exposure.	3-methyladenine	8-23	phosphatidylinositol 3-kinase catalytic subunit type 3	Mus musculus	129-135
32061152-4	2020	We used 3-methyladenine (3-MA) and ABT-737 to suppress the expression of phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) and B cell leukemia/lymphoma 2 (Bcl-2), two critical initiators of autophagy, and detected and evaluated the autophagy in NR8383 cells with or without silica dust exposure.	3-methyladenine	8-23	B cell leukemia/lymphoma 2	Mus musculus	141-167
32061152-4	2020	We used 3-methyladenine (3-MA) and ABT-737 to suppress the expression of phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) and B cell leukemia/lymphoma 2 (Bcl-2), two critical initiators of autophagy, and detected and evaluated the autophagy in NR8383 cells with or without silica dust exposure.	3-methyladenine	8-23	B cell leukemia/lymphoma 2	Mus musculus	169-174
32061152-4	2020	We used 3-methyladenine (3-MA) and ABT-737 to suppress the expression of phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) and B cell leukemia/lymphoma 2 (Bcl-2), two critical initiators of autophagy, and detected and evaluated the autophagy in NR8383 cells with or without silica dust exposure.	3-methyladenine	25-29	phosphatidylinositol 3-kinase catalytic subunit type 3	Mus musculus	73-127
32061152-4	2020	We used 3-methyladenine (3-MA) and ABT-737 to suppress the expression of phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) and B cell leukemia/lymphoma 2 (Bcl-2), two critical initiators of autophagy, and detected and evaluated the autophagy in NR8383 cells with or without silica dust exposure.	3-methyladenine	25-29	phosphatidylinositol 3-kinase catalytic subunit type 3	Mus musculus	129-135
32061152-4	2020	We used 3-methyladenine (3-MA) and ABT-737 to suppress the expression of phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) and B cell leukemia/lymphoma 2 (Bcl-2), two critical initiators of autophagy, and detected and evaluated the autophagy in NR8383 cells with or without silica dust exposure.	3-methyladenine	25-29	B cell leukemia/lymphoma 2	Mus musculus	141-167
32061152-4	2020	We used 3-methyladenine (3-MA) and ABT-737 to suppress the expression of phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) and B cell leukemia/lymphoma 2 (Bcl-2), two critical initiators of autophagy, and detected and evaluated the autophagy in NR8383 cells with or without silica dust exposure.	3-methyladenine	25-29	B cell leukemia/lymphoma 2	Mus musculus	169-174
31974677-10	2020	Furthermore, ANCR could significantly increase LC3 and autophagy protein 5 expression in beta-GP-stimulated VSMCs, and the effect could be inhibited by 3-methyladenine, a pharmacological inhibitor of autophagy.	3-methyladenine	152-167	Angelman syndrome chromosome region	Homo sapiens	13-17
31974677-10	2020	Furthermore, ANCR could significantly increase LC3 and autophagy protein 5 expression in beta-GP-stimulated VSMCs, and the effect could be inhibited by 3-methyladenine, a pharmacological inhibitor of autophagy.	3-methyladenine	152-167	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	47-50
32272506-8	2020	However, 3-methyladenine, an autophagy inhibitor, reversed the inhibitory effects of BBR on mitochondrial damage and NLRP3 inflammasome activation in influenza virus-infected macrophages, indicating the involvement of mitophagy in mediating the inhibitory effects of BBR on NLRP3 inflammasome activation.	3-methyladenine	9-24	NLR family pyrin domain containing 3	Homo sapiens	117-122
32272506-8	2020	However, 3-methyladenine, an autophagy inhibitor, reversed the inhibitory effects of BBR on mitochondrial damage and NLRP3 inflammasome activation in influenza virus-infected macrophages, indicating the involvement of mitophagy in mediating the inhibitory effects of BBR on NLRP3 inflammasome activation.	3-methyladenine	9-24	NLR family pyrin domain containing 3	Homo sapiens	274-279
32319654-4	2020	Compared with the controls, the 17-AAG-treated mice exhibited significantly decreased expression levels of phosphorylated (p)-Akt and p-mTOR with enhanced autophagy and apoptosis; no marked increases in the expression levels of p-Akt and p-mTOR were observed in the 3-MA-treated mice, with no significant changes in autophagy; however, apoptosis was enhanced.	3-methyladenine	266-270	N-methylpurine-DNA glycosylase	Mus musculus	35-38
32319654-6	2020	Compared with 17-AAG alone, the combination of 17-AAG and 3-MA resulted in a marked increase in apoptosis without enhanced autophagy.	3-methyladenine	58-62	N-methylpurine-DNA glycosylase	Mus musculus	17-20
32346844-6	2020	However, this effect was impaired by inhibiting autophagy with 3-methyladenine, suggesting that the MTOR signaling pathway is a functional target of EZH2.	3-methyladenine	63-78	mechanistic target of rapamycin kinase	Rattus norvegicus	100-104
32346844-6	2020	However, this effect was impaired by inhibiting autophagy with 3-methyladenine, suggesting that the MTOR signaling pathway is a functional target of EZH2.	3-methyladenine	63-78	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	149-153
32537026-6	2020	Furthermore, pharmacologically inhibiting autophagy with chloroquine and 3-methyladenine decreased SPAG6 knockdown-mediated apoptosis, indicating that SPAG6 knockdown-mediated autophagy promoted apoptosis in SKM-1 cells.	3-methyladenine	73-88	sperm associated antigen 6	Homo sapiens	99-104
32895198-6	2020	The effect of EV71 infection on apoptosis of THP-1 macrophages incubated with 3-MA and Ac-DEVD-CHO inhibitor for 2 h was assessed using Western blotting.	3-methyladenine	78-82	GLI family zinc finger 2	Homo sapiens	45-50
32895198-12	2020	3-MA significantly inhibited the EV71-induced autophagy of THP-1 macrophages and reduced LC3 conversion (LC3-II/LC3-I) and p62 protein expression at 8 h after EV71 infection (P < 0.01).	3-methyladenine	0-4	GLI family zinc finger 2	Homo sapiens	59-64
32895198-12	2020	3-MA significantly inhibited the EV71-induced autophagy of THP-1 macrophages and reduced LC3 conversion (LC3-II/LC3-I) and p62 protein expression at 8 h after EV71 infection (P < 0.01).	3-methyladenine	0-4	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	89-92
32895198-12	2020	3-MA significantly inhibited the EV71-induced autophagy of THP-1 macrophages and reduced LC3 conversion (LC3-II/LC3-I) and p62 protein expression at 8 h after EV71 infection (P < 0.01).	3-methyladenine	0-4	nucleoporin 62	Homo sapiens	123-126
32685096-8	2020	However, the mitophagy inhibitor, 3-Methyladenine, blocked these protective effects of Drp-1.	3-methyladenine	34-49	dynamin 1-like	Rattus norvegicus	87-92
32606611-7	2020	In addition, the AS + DH + BBR + 3-MA group exhibited a significantly enlarged plaque, substantial foam cell and macrophage infiltration, increased levels of IL-1beta and TNF-alpha, and decreased LC3-II and P62 (P < 0.01) expression when compared to the AS + DH + BBR group.	3-methyladenine	33-37	interleukin 1 alpha	Rattus norvegicus	158-166
32606611-7	2020	In addition, the AS + DH + BBR + 3-MA group exhibited a significantly enlarged plaque, substantial foam cell and macrophage infiltration, increased levels of IL-1beta and TNF-alpha, and decreased LC3-II and P62 (P < 0.01) expression when compared to the AS + DH + BBR group.	3-methyladenine	33-37	tumor necrosis factor	Rattus norvegicus	171-180
32606611-7	2020	In addition, the AS + DH + BBR + 3-MA group exhibited a significantly enlarged plaque, substantial foam cell and macrophage infiltration, increased levels of IL-1beta and TNF-alpha, and decreased LC3-II and P62 (P < 0.01) expression when compared to the AS + DH + BBR group.	3-methyladenine	33-37	annexin A3	Rattus norvegicus	196-199
32606611-7	2020	In addition, the AS + DH + BBR + 3-MA group exhibited a significantly enlarged plaque, substantial foam cell and macrophage infiltration, increased levels of IL-1beta and TNF-alpha, and decreased LC3-II and P62 (P < 0.01) expression when compared to the AS + DH + BBR group.	3-methyladenine	33-37	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	207-210
32655948-11	2020	In addition, 3-MA markedly increased KIM1, NGAL, and the activity of caspase-3 in the hypoxic HK-2 and AC16 cell.	3-methyladenine	13-17	hepatitis A virus cellular receptor 1	Homo sapiens	37-41
32655948-11	2020	In addition, 3-MA markedly increased KIM1, NGAL, and the activity of caspase-3 in the hypoxic HK-2 and AC16 cell.	3-methyladenine	13-17	lipocalin 2	Homo sapiens	43-47
32655948-11	2020	In addition, 3-MA markedly increased KIM1, NGAL, and the activity of caspase-3 in the hypoxic HK-2 and AC16 cell.	3-methyladenine	13-17	caspase 3	Homo sapiens	69-78
32555189-4	2020	Administration of 3-MA at 21 days following after uric acid injury protected kidney from hyperuricemic-related injuries, as demonstrated by improving renal dysfunction and architecture damage, blocking Beclin-1 and LC3II/I and decreasing the number of autophagic vacuoles.	3-methyladenine	18-22	beclin 1	Homo sapiens	202-210
32555189-6	2020	Injury to the kidney resulted in increased expression of TGFbeta receptor I, and phosphorylation of Smad3, 3-MA significantly abrogated all these responses.	3-methyladenine	107-111	SMAD family member 3	Homo sapiens	100-105
32555189-8	2020	Finally, 3-MA effectively blocked STAT3 and NF-kappaB phosphorylation and suppressed infiltration of macrophages and lymphocytes as well as release of multiple profibrogenic cytokines/chemokines in the injured kidney.	3-methyladenine	9-13	signal transducer and activator of transcription 3	Homo sapiens	34-39
32555189-8	2020	Finally, 3-MA effectively blocked STAT3 and NF-kappaB phosphorylation and suppressed infiltration of macrophages and lymphocytes as well as release of multiple profibrogenic cytokines/chemokines in the injured kidney.	3-methyladenine	9-13	nuclear factor kappa B subunit 1	Homo sapiens	44-53
32655783-11	2020	More importantly, LINC00265 overexpression or miR-485-5p inhibitor reversed the 3-methyladenine (3-MA, an autophagy inhibitor)-mediated proliferation-inhibitory and pro-apoptotic effects, whereas LINC00265 silencing or miR-485-5p mimic overturned the proliferation-promoting and anti-apoptotic effects of autophagy activator rapamycin.	3-methyladenine	80-95	long intergenic non-protein coding RNA 265	Homo sapiens	18-27
32655783-11	2020	More importantly, LINC00265 overexpression or miR-485-5p inhibitor reversed the 3-methyladenine (3-MA, an autophagy inhibitor)-mediated proliferation-inhibitory and pro-apoptotic effects, whereas LINC00265 silencing or miR-485-5p mimic overturned the proliferation-promoting and anti-apoptotic effects of autophagy activator rapamycin.	3-methyladenine	80-95	microRNA 485	Homo sapiens	46-53
32655783-11	2020	More importantly, LINC00265 overexpression or miR-485-5p inhibitor reversed the 3-methyladenine (3-MA, an autophagy inhibitor)-mediated proliferation-inhibitory and pro-apoptotic effects, whereas LINC00265 silencing or miR-485-5p mimic overturned the proliferation-promoting and anti-apoptotic effects of autophagy activator rapamycin.	3-methyladenine	97-101	long intergenic non-protein coding RNA 265	Homo sapiens	18-27
32655783-11	2020	More importantly, LINC00265 overexpression or miR-485-5p inhibitor reversed the 3-methyladenine (3-MA, an autophagy inhibitor)-mediated proliferation-inhibitory and pro-apoptotic effects, whereas LINC00265 silencing or miR-485-5p mimic overturned the proliferation-promoting and anti-apoptotic effects of autophagy activator rapamycin.	3-methyladenine	97-101	long intergenic non-protein coding RNA 265	Homo sapiens	196-205
32655783-11	2020	More importantly, LINC00265 overexpression or miR-485-5p inhibitor reversed the 3-methyladenine (3-MA, an autophagy inhibitor)-mediated proliferation-inhibitory and pro-apoptotic effects, whereas LINC00265 silencing or miR-485-5p mimic overturned the proliferation-promoting and anti-apoptotic effects of autophagy activator rapamycin.	3-methyladenine	97-101	microRNA 485	Homo sapiens	46-53
32655831-6	2020	Blocking autophagy by 3-MA or silenced Beclin1 attenuated BMP4-induced autophagy and cell invasion.	3-methyladenine	22-26	bone morphogenetic protein 4	Homo sapiens	58-62
32549974-8	2020	Furthermore, the DOR-mediated protective effects on ischemic CA1 neurons were abolished by the autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	115-130	carbonic anhydrase 1	Homo sapiens	61-64
32549974-8	2020	Furthermore, the DOR-mediated protective effects on ischemic CA1 neurons were abolished by the autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	132-136	carbonic anhydrase 1	Homo sapiens	61-64
32545902-9	2020	Addition of 3MA caused a significant increase of P62, superoxides, and caspase 3/7 activities in the 661 W cells cultured in high glucose but not in low glucose.	3-methyladenine	12-15	nucleoporin 62	Mus musculus	49-52
32545902-9	2020	Addition of 3MA caused a significant increase of P62, superoxides, and caspase 3/7 activities in the 661 W cells cultured in high glucose but not in low glucose.	3-methyladenine	12-15	caspase 3	Mus musculus	71-82
32595492-14	2020	Notably, inhibition of autophagy with 3-methyladenine in APF-treated RMCs aggravated cellular damage and altered mTOR/PINK1/Parkin signaling, indicating that APF rescued HG damage through promoting autophagy.	3-methyladenine	38-53	mechanistic target of rapamycin kinase	Mus musculus	113-117
32595492-14	2020	Notably, inhibition of autophagy with 3-methyladenine in APF-treated RMCs aggravated cellular damage and altered mTOR/PINK1/Parkin signaling, indicating that APF rescued HG damage through promoting autophagy.	3-methyladenine	38-53	PTEN induced putative kinase 1	Mus musculus	118-123
32517337-7	2020	The vasicinone mediated autophagy pathways were abrogated by treatment with the autophagy inhibitor 3-MA, which lead to increases alpha-synuclein accumulation and decreased the expression of p-ULK and ATG proteins and the autophagy marker LC3-II compared to that observed without 3-MA treatment.	3-methyladenine	100-104	synuclein alpha	Homo sapiens	130-145
31815524-9	2020	Meanwhile, AMPK inhibitor Compound C and autophagy inhibitor 3-methyladenine (3-MA) reversed these changes following VD treatment.	3-methyladenine	78-82	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	11-15
32141386-5	2020	3-methyladenine (3-MA) and chloroquine (CQ) could inhibit the activity of ALP, PINP and the autophagy in LF group.	3-methyladenine	0-15	alkaline phosphatase, placental	Homo sapiens	74-77
32141386-5	2020	3-methyladenine (3-MA) and chloroquine (CQ) could inhibit the activity of ALP, PINP and the autophagy in LF group.	3-methyladenine	17-21	alkaline phosphatase, placental	Homo sapiens	74-77
32544612-8	2020	In contrast, autophagic inhibition by 3-methyladenine partially normalized hypertension, proteinuria and placental angiogenic imbalance in PKCbeta-inhibited mice.	3-methyladenine	38-53	protein kinase C, alpha	Mus musculus	139-146
32128658-6	2020	However, inhibition of autophagy by 3-methyladenine or chloroquine significantly reduced the anti-inflammatory effect of GSTP1.	3-methyladenine	36-51	glutathione S-transferase pi 1	Homo sapiens	121-126
32299030-8	2020	Moreover, increased Bcl-2 and Bax levels were observed after treatment with an agonist (rapamycin) and antagonist (3MA) of autophagy in high-glucose-cultured cells.	3-methyladenine	115-118	BCL2, apoptosis regulator	Rattus norvegicus	20-25
32299030-8	2020	Moreover, increased Bcl-2 and Bax levels were observed after treatment with an agonist (rapamycin) and antagonist (3MA) of autophagy in high-glucose-cultured cells.	3-methyladenine	115-118	BCL2 associated X, apoptosis regulator	Rattus norvegicus	30-33
32323792-6	2020	PARP-1 expression was not altered when treated with ERS inhibitor 4PBA and autophagy inhibitor 3MA, whereas 4PBA or 3MA in combination with 2 mM melatonin (or the three together) significantly increased PARP-1 expression.	3-methyladenine	116-119	poly(ADP-ribose) polymerase 1	Homo sapiens	203-209
31654225-4	2020	In this study, we have shown that DEX and DEX + RAPA (autophagy inducer) increased viability and reduced apoptosis of primary astrocytes in oxygen-glucose deprivation (OGD) model compared with DEX + 3-methyladenine (3-MA) (autophagy inhibitor).	3-methyladenine	216-220	transcriptional regulating factor 1	Homo sapiens	48-52
32466291-7	2020	Lysosome accumulation and lysosome-associated membrane protein-2 (LAMP2) depletion were observed after DFIQ treatment, and cell death induction was restored upon treatment with the autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	201-216	lysosomal-associated membrane protein 2	Danio rerio	26-64
32466291-7	2020	Lysosome accumulation and lysosome-associated membrane protein-2 (LAMP2) depletion were observed after DFIQ treatment, and cell death induction was restored upon treatment with the autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	201-216	lysosomal-associated membrane protein 2	Danio rerio	66-71
32466291-7	2020	Lysosome accumulation and lysosome-associated membrane protein-2 (LAMP2) depletion were observed after DFIQ treatment, and cell death induction was restored upon treatment with the autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	218-222	lysosomal-associated membrane protein 2	Danio rerio	26-64
32466291-7	2020	Lysosome accumulation and lysosome-associated membrane protein-2 (LAMP2) depletion were observed after DFIQ treatment, and cell death induction was restored upon treatment with the autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	218-222	lysosomal-associated membrane protein 2	Danio rerio	66-71
31968231-7	2020	Blocking autophagy using 3-methyladenine led to cell death via activation of enhanced ROS, PARP-1 and caspase 3 cleavage.	3-methyladenine	25-40	poly(ADP-ribose) polymerase 1	Homo sapiens	91-97
31968231-7	2020	Blocking autophagy using 3-methyladenine led to cell death via activation of enhanced ROS, PARP-1 and caspase 3 cleavage.	3-methyladenine	25-40	caspase 3	Homo sapiens	102-111
32424110-13	2020	After inhibiting autophagy with 3-MA or CQ, compared with OA alone, cell mitochondrial membrane potential and ATP concentration were significantly reduced, cell p62 expression was reduced, and LC3-II expression was increased, apoptosis-related protein Bax protein was increased, and Bcl-2 protein was decreased, which suggested that 3-MA or CQ treatment increased OA-induced apoptosis of SMMC-7721 cells.	3-methyladenine	32-36	nucleoporin 62	Homo sapiens	161-164
32424110-13	2020	After inhibiting autophagy with 3-MA or CQ, compared with OA alone, cell mitochondrial membrane potential and ATP concentration were significantly reduced, cell p62 expression was reduced, and LC3-II expression was increased, apoptosis-related protein Bax protein was increased, and Bcl-2 protein was decreased, which suggested that 3-MA or CQ treatment increased OA-induced apoptosis of SMMC-7721 cells.	3-methyladenine	32-36	BCL2 associated X, apoptosis regulator	Homo sapiens	252-255
32424110-13	2020	After inhibiting autophagy with 3-MA or CQ, compared with OA alone, cell mitochondrial membrane potential and ATP concentration were significantly reduced, cell p62 expression was reduced, and LC3-II expression was increased, apoptosis-related protein Bax protein was increased, and Bcl-2 protein was decreased, which suggested that 3-MA or CQ treatment increased OA-induced apoptosis of SMMC-7721 cells.	3-methyladenine	32-36	BCL2 apoptosis regulator	Homo sapiens	283-288
32414129-4	2020	Inhibition of autophagy by a chemical agent (such as chloroquine, bafilomycin A1, or 3-methyladenine) increases the AHR protein levels in HeLa cells whereas activation of autophagy by short-term nutrition deprivation reduces its levels.	3-methyladenine	85-100	aryl hydrocarbon receptor	Homo sapiens	116-119
32397071-10	2020	The mRNA levels of IL-6, IL-1beta, TNF-alpha, and autophagy-related genes were detected after adding niacin, shRNA, compound C, trans retinoic acid, 3-methyladenine to BMECs.	3-methyladenine	149-164	interferon beta-2	Bos taurus	19-23
32397071-10	2020	The mRNA levels of IL-6, IL-1beta, TNF-alpha, and autophagy-related genes were detected after adding niacin, shRNA, compound C, trans retinoic acid, 3-methyladenine to BMECs.	3-methyladenine	149-164	interleukin 1 alpha	Bos taurus	25-33
32397071-10	2020	The mRNA levels of IL-6, IL-1beta, TNF-alpha, and autophagy-related genes were detected after adding niacin, shRNA, compound C, trans retinoic acid, 3-methyladenine to BMECs.	3-methyladenine	149-164	tumor necrosis factor	Bos taurus	35-44
32432106-6	2020	Pretreatment with 3-methyladenine (3-MA) inhibited autophagy and enhanced oxidative stress and the production of TNF-alpha.	3-methyladenine	18-33	tumor necrosis factor	Ovis aries	113-122
32432106-6	2020	Pretreatment with 3-methyladenine (3-MA) inhibited autophagy and enhanced oxidative stress and the production of TNF-alpha.	3-methyladenine	35-39	tumor necrosis factor	Ovis aries	113-122
32319603-5	2020	However, the suppression of autophagy by 3-methyladenine could block ADAM12 silencing-induced cellular apoptosis.	3-methyladenine	41-56	ADAM metallopeptidase domain 12	Homo sapiens	69-75
32319603-7	2020	The downregulation of p-mTOR expression by ADAM12 silencing was rescued in 3-methyladenine-treated JEG-3 cells, indicating that mTOR might participate in the autophagy-mediated pro-apoptotic effect of ADAM12 silencing.	3-methyladenine	75-90	mechanistic target of rapamycin kinase	Homo sapiens	24-28
32319603-7	2020	The downregulation of p-mTOR expression by ADAM12 silencing was rescued in 3-methyladenine-treated JEG-3 cells, indicating that mTOR might participate in the autophagy-mediated pro-apoptotic effect of ADAM12 silencing.	3-methyladenine	75-90	ADAM metallopeptidase domain 12	Homo sapiens	43-49
32319603-7	2020	The downregulation of p-mTOR expression by ADAM12 silencing was rescued in 3-methyladenine-treated JEG-3 cells, indicating that mTOR might participate in the autophagy-mediated pro-apoptotic effect of ADAM12 silencing.	3-methyladenine	75-90	mechanistic target of rapamycin kinase	Homo sapiens	128-132
32319603-7	2020	The downregulation of p-mTOR expression by ADAM12 silencing was rescued in 3-methyladenine-treated JEG-3 cells, indicating that mTOR might participate in the autophagy-mediated pro-apoptotic effect of ADAM12 silencing.	3-methyladenine	75-90	ADAM metallopeptidase domain 12	Homo sapiens	201-207
31916058-9	2020	However, with 3-MA treatment, the number of RCGs in 3-MA-treated IRI group was elevated and protein levels of LC3, Beclin-1 were down-regulated, compared with those in the IRI group (P &lt; 0.05).	3-methyladenine	14-18	beclin 1	Rattus norvegicus	115-123
31916058-10	2020	Further immunohistochemistry staining and Western blot showed that 3-MA-treated IRI group presented down-regulated Caspase-3 and up-regulated Bcl-2 protein expression with comparison of IRI group (P &lt; 0.05).	3-methyladenine	67-71	caspase 3	Rattus norvegicus	115-124
31916058-10	2020	Further immunohistochemistry staining and Western blot showed that 3-MA-treated IRI group presented down-regulated Caspase-3 and up-regulated Bcl-2 protein expression with comparison of IRI group (P &lt; 0.05).	3-methyladenine	67-71	BCL2, apoptosis regulator	Rattus norvegicus	142-147
31922269-5	2020	Autophagy inhibitor 3-methyladenine (3-MA) alleviated PEG-Fe3 O4 nanoparticle-induced mitochondrial instability and impairment of the functionally immature state of DCs due to unexpected enhancement of PGC1alpha/MFN2-mediated coordination of mitochondrial biogenesis and fusion.	3-methyladenine	20-35	PPARG coactivator 1 alpha	Homo sapiens	202-211
31922269-5	2020	Autophagy inhibitor 3-methyladenine (3-MA) alleviated PEG-Fe3 O4 nanoparticle-induced mitochondrial instability and impairment of the functionally immature state of DCs due to unexpected enhancement of PGC1alpha/MFN2-mediated coordination of mitochondrial biogenesis and fusion.	3-methyladenine	20-35	mitofusin 2	Homo sapiens	212-216
31922269-5	2020	Autophagy inhibitor 3-methyladenine (3-MA) alleviated PEG-Fe3 O4 nanoparticle-induced mitochondrial instability and impairment of the functionally immature state of DCs due to unexpected enhancement of PGC1alpha/MFN2-mediated coordination of mitochondrial biogenesis and fusion.	3-methyladenine	37-41	PPARG coactivator 1 alpha	Homo sapiens	202-211
31922269-5	2020	Autophagy inhibitor 3-methyladenine (3-MA) alleviated PEG-Fe3 O4 nanoparticle-induced mitochondrial instability and impairment of the functionally immature state of DCs due to unexpected enhancement of PGC1alpha/MFN2-mediated coordination of mitochondrial biogenesis and fusion.	3-methyladenine	37-41	mitofusin 2	Homo sapiens	212-216
31637712-8	2020	Importantly, the protective effects of Lin28a and Mst1 disappeared after treatment with 3-methyladenine, an autophagy inhibitor.	3-methyladenine	88-103	lin-28 homolog A	Mus musculus	39-45
31637712-8	2020	Importantly, the protective effects of Lin28a and Mst1 disappeared after treatment with 3-methyladenine, an autophagy inhibitor.	3-methyladenine	88-103	macrophage stimulating 1 (hepatocyte growth factor-like)	Mus musculus	50-54
32301281-7	2020	The expression levels of LC3-II, Beclin1 and lncRNA H19 were increased in intestinal tissues and IEC-6 cells after rapamycin treatment but were reversed after 3-MA treatment.	3-methyladenine	159-163	beclin 1	Rattus norvegicus	33-40
32547612-12	2020	In addition, Egr-1 knockdown induced autophagy was suppressed by 3-MA treatments.	3-methyladenine	65-69	early growth response 1	Rattus norvegicus	13-18
32265437-6	2020	Mechanistically, we find that alteronol significantly inhibits Akt/mTOR and TGFbeta/Smad3 pathways, and co-treatment with autophagy inhibitor 3-MA further potentiate these effects.	3-methyladenine	142-146	transforming growth factor alpha	Homo sapiens	76-83
32265437-6	2020	Mechanistically, we find that alteronol significantly inhibits Akt/mTOR and TGFbeta/Smad3 pathways, and co-treatment with autophagy inhibitor 3-MA further potentiate these effects.	3-methyladenine	142-146	SMAD family member 3	Homo sapiens	84-89
32248306-8	2020	The protective effect of CARD9 on cardiomyocytes against H/R-induced oxidative stress was abolished by treatment with autophagy inhibitors, 3-methyladenine (3-MA) or Bafilomycin A1(BafA1).	3-methyladenine	140-155	caspase recruitment domain family, member 9	Mus musculus	25-30
32248306-8	2020	The protective effect of CARD9 on cardiomyocytes against H/R-induced oxidative stress was abolished by treatment with autophagy inhibitors, 3-methyladenine (3-MA) or Bafilomycin A1(BafA1).	3-methyladenine	157-161	caspase recruitment domain family, member 9	Mus musculus	25-30
32072231-8	2020	After treated with 3-methyladenine, the expression of decidual markers HOXA10 and progesterone receptor were significantly reduced.	3-methyladenine	19-34	homeobox A10	Mus musculus	71-77
32072231-8	2020	After treated with 3-methyladenine, the expression of decidual markers HOXA10 and progesterone receptor were significantly reduced.	3-methyladenine	19-34	progesterone receptor	Mus musculus	82-103
32072231-10	2020	In addition, impaired uterine decidualization and dysregulation of the PR and HOXA10 protein levels was observed after autophagy inhibited by 3-methyladenine and chloroquine in in vivo artificial decidualization mouse model.	3-methyladenine	142-157	homeobox A10	Mus musculus	78-84
32032574-5	2020	Treatment of mice at P7 with rapamycin or 3-methyladenine (activator and inhibitor of autophagy, respectively) for 7 days led to the significant elevations of hearing threshold across frequencies from P15 to P30.	3-methyladenine	42-57	cyclin dependent kinase inhibitor 2B	Mus musculus	201-204
32032574-5	2020	Treatment of mice at P7 with rapamycin or 3-methyladenine (activator and inhibitor of autophagy, respectively) for 7 days led to the significant elevations of hearing threshold across frequencies from P15 to P30.	3-methyladenine	42-57	high mobility group box 1	Mus musculus	208-211
32235551-7	2020	In contrast, blocking autophagosome formation with 3-methyladenine rescued the mitigated metastatic potential in vitro and in vivo in IMPA2-overexpressing ccRCC cells.	3-methyladenine	51-66	inositol monophosphatase 2	Homo sapiens	134-139
32169114-10	2020	OGD-induced occludin degradation and permeability changes were significantly decreased by inhibition of autophagy using 3-methyladenine (3-MA).	3-methyladenine	120-135	occludin	Rattus norvegicus	12-20
32169114-10	2020	OGD-induced occludin degradation and permeability changes were significantly decreased by inhibition of autophagy using 3-methyladenine (3-MA).	3-methyladenine	137-141	occludin	Rattus norvegicus	12-20
32256964-6	2020	More interestingly, DpdtC could also inhibit EMT, leading to the upregulation of E-cadherin and the downregulation of vimentin; however, the addition of NAC and 3-MA could attenuate (or neutralize) the action of DpdtC on ferritinophagy induction and EMT inhibition, supporting that the enhanced ferritinophagic flux contributed to the EMT inhibition.	3-methyladenine	161-165	vimentin	Homo sapiens	118-126
31522488-12	2020	In addition, the co-administration of the autophagy inhibitor 3-methyladenine and fluoxetine significantly increased fluoxetine-induced apoptosis, with decreased p-Akt and markedly increased death receptor 4 and 5 expression.	3-methyladenine	62-77	TNF receptor superfamily member 10a	Homo sapiens	191-213
32104285-12	2020	Under LPS treatment, the NF-kappaB pathway inhibitor BAY11-7082 further enhanced the inhibitory effects of rapamycin, but inhibited the promoting effects of 3-MA on the protein expression levels of IL-1beta and caspase-1.	3-methyladenine	157-161	interleukin 1 alpha	Homo sapiens	198-206
32104285-12	2020	Under LPS treatment, the NF-kappaB pathway inhibitor BAY11-7082 further enhanced the inhibitory effects of rapamycin, but inhibited the promoting effects of 3-MA on the protein expression levels of IL-1beta and caspase-1.	3-methyladenine	157-161	caspase 1	Homo sapiens	211-220
31478571-7	2020	Autophagy inhibition via 3-methyladenine reversed HOTAIR stimulatory effects on apoptosis, senescence, and ECM catabolism, while the AMP-activated protein kinase (AMPK) inhibitor Compound C suppressed HOTAIR-induced autophagy through regulating AMPK/mTOR/ULK1 pathways.	3-methyladenine	25-40	HOX transcript antisense RNA	Homo sapiens	50-56
31535378-13	2020	The PI3K inhibitor 3-methyladenine partly blocked OPG-induced autophagy.	3-methyladenine	19-34	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	50-53
31659628-10	2020	Inhibition of autophagy by 3-methyladenine or by silencing Atg5 gene enabled CCN1-induced apoptosis in H9c2 cells, suggesting a protective role of autophagy.	3-methyladenine	27-42	cellular communication network factor 1	Mus musculus	77-81
31571659-13	2020	The addition of the autophagy inhibitor 3-methyladenine or dorsomorphin before OGD/R attenuated the activation of the LKB1-AMPK-mTOR signaling pathway in cells treated with LIG.	3-methyladenine	40-55	serine/threonine kinase 11	Rattus norvegicus	118-122
31571659-13	2020	The addition of the autophagy inhibitor 3-methyladenine or dorsomorphin before OGD/R attenuated the activation of the LKB1-AMPK-mTOR signaling pathway in cells treated with LIG.	3-methyladenine	40-55	mechanistic target of rapamycin kinase	Rattus norvegicus	128-132
31637455-8	2020	The miR-211-induced apoptosis was alleviated by an autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	71-86	microRNA 211	Homo sapiens	4-11
31637455-8	2020	The miR-211-induced apoptosis was alleviated by an autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	88-92	microRNA 211	Homo sapiens	4-11
32210724-9	2020	Treatment with 3-MA abolished nicotine-mediated increase in the levels of autophagy-related proteins and phosphorylation of GSK3beta, but had no effect on ROS production.	3-methyladenine	15-19	glycogen synthase kinase 3 alpha	Rattus norvegicus	124-132
32054506-4	2020	The associations between ERbeta and autophagy were detected in osteosarcoma U2-OS cells which were treated with E2, E2 + 2,3-Bis (4-hydroxyphenyl) propionitrile (DPN, ERbeta agonists), E2 + DPN + water, E2 + DPN + 3-Methyladenine (3-MA, autophagy inhibitor), respectively.	3-methyladenine	214-229	estrogen receptor 1	Homo sapiens	25-31
32054506-4	2020	The associations between ERbeta and autophagy were detected in osteosarcoma U2-OS cells which were treated with E2, E2 + 2,3-Bis (4-hydroxyphenyl) propionitrile (DPN, ERbeta agonists), E2 + DPN + water, E2 + DPN + 3-Methyladenine (3-MA, autophagy inhibitor), respectively.	3-methyladenine	231-235	estrogen receptor 1	Homo sapiens	25-31
32015215-5	2020	These effects were reversed by treatment with the early autophagy inhibitor 3-methyl adenine, which suggests HO-1-induced autophagy suppresses IL-1beta-induced apoptosis in NPCs.	3-methyladenine	76-92	heme oxygenase 1	Homo sapiens	109-113
32015215-5	2020	These effects were reversed by treatment with the early autophagy inhibitor 3-methyl adenine, which suggests HO-1-induced autophagy suppresses IL-1beta-induced apoptosis in NPCs.	3-methyladenine	76-92	interleukin 1 alpha	Homo sapiens	143-151
31734315-8	2020	Sim preconditioning also prevented the depletion of SIRT1 induced by HI, an effect that was completely blocked by 3MA.	3-methyladenine	114-117	sirtuin 1	Rattus norvegicus	52-57
32010254-9	2020	The expression levels of NLRP3, caspase-1 and IL-1beta were inhibited after the addition of autophagy inhibitor 3-MA.	3-methyladenine	112-116	NLR family pyrin domain containing 3	Homo sapiens	25-30
32010254-9	2020	The expression levels of NLRP3, caspase-1 and IL-1beta were inhibited after the addition of autophagy inhibitor 3-MA.	3-methyladenine	112-116	caspase 1	Homo sapiens	32-41
32010254-9	2020	The expression levels of NLRP3, caspase-1 and IL-1beta were inhibited after the addition of autophagy inhibitor 3-MA.	3-methyladenine	112-116	interleukin 1 alpha	Homo sapiens	46-54
31661991-7	2020	Additionally, MEHP induced the collapse of mitochondrial transmembrane potential and release of cytochrome c. Addition of autophagy inhibitor 3-methyladenine relieved MEHP-induced apoptosis as assessed by the expression of cleaved caspase 3, cleaved caspase 9, and terminal deoxynucleotidyl transferase dUTP nick end labeling assay, indicating that MEHP-induced apoptosis was autophagy dependent.	3-methyladenine	142-157	caspase 3	Rattus norvegicus	231-240
31661991-7	2020	Additionally, MEHP induced the collapse of mitochondrial transmembrane potential and release of cytochrome c. Addition of autophagy inhibitor 3-methyladenine relieved MEHP-induced apoptosis as assessed by the expression of cleaved caspase 3, cleaved caspase 9, and terminal deoxynucleotidyl transferase dUTP nick end labeling assay, indicating that MEHP-induced apoptosis was autophagy dependent.	3-methyladenine	142-157	caspase 9	Rattus norvegicus	250-259
30621446-5	2020	Importantly, the protective effects of isopsoralen against IL-1beta were blocked by pretreatment with autophagy inhibitor 3-MA and bafilomycin A1.	3-methyladenine	122-126	interleukin 1 beta	Rattus norvegicus	59-67
31332791-10	2020	If 3-MA was used to inhibit autophagy in Rac1 and Rac3 knockdown cells, the injury induced by ox-LDL on the cells was recovered.	3-methyladenine	3-7	Rac family small GTPase 1	Mus musculus	41-45
31332791-10	2020	If 3-MA was used to inhibit autophagy in Rac1 and Rac3 knockdown cells, the injury induced by ox-LDL on the cells was recovered.	3-methyladenine	3-7	Rac family small GTPase 3	Mus musculus	50-54
31453635-7	2020	Effects of IL-1beta on the development of embryo reduced in 20 ng/mL IL-1beta supplemented group when 5 mM 3-methyladenine (3-MA) was also added, which used to inhibit autophagy activation in endogenous PtdIns3Ks signal pathway.	3-methyladenine	107-122	interleukin 1 beta	Mus musculus	69-77
31453635-7	2020	Effects of IL-1beta on the development of embryo reduced in 20 ng/mL IL-1beta supplemented group when 5 mM 3-methyladenine (3-MA) was also added, which used to inhibit autophagy activation in endogenous PtdIns3Ks signal pathway.	3-methyladenine	124-128	interleukin 1 beta	Mus musculus	69-77
31881227-9	2020	KEY FINDINGS: BBR induced autophagy in p53-null leukemic cells, which was inhibited by autophagy inhibitors 3-methyladenine.	3-methyladenine	108-123	transformation related protein 53, pseudogene	Mus musculus	39-42
31753050-8	2020	Additionally, autophagy inhibition by 3-methyladenine (after 24 h) increased CD63 protein signals during late spermatogenesis, as detected by IF and WB.	3-methyladenine	38-53	CD63 molecule	Homo sapiens	77-81
32099325-9	2020	3-methyladenine (3-MA) significantly decreased LC3 (LC3II)+ puncta, but genipin rescuect 3d this reduction.	3-methyladenine	0-15	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	47-50
32099325-9	2020	3-methyladenine (3-MA) significantly decreased LC3 (LC3II)+ puncta, but genipin rescuect 3d this reduction.	3-methyladenine	0-15	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	52-57
32099325-9	2020	3-methyladenine (3-MA) significantly decreased LC3 (LC3II)+ puncta, but genipin rescuect 3d this reduction.	3-methyladenine	17-21	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	47-50
32099325-9	2020	3-methyladenine (3-MA) significantly decreased LC3 (LC3II)+ puncta, but genipin rescuect 3d this reduction.	3-methyladenine	17-21	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	52-57
32047439-5	2019	In angiotensin II (Ang II)-treated EPCs, enhancing autophagy through rapamycin mitigated Ang II-induced cell senescence, on the contrary, 3-methyladenine aggravated the senescence by weakening autophagy.	3-methyladenine	138-153	angiotensinogen	Homo sapiens	3-17
32047439-5	2019	In angiotensin II (Ang II)-treated EPCs, enhancing autophagy through rapamycin mitigated Ang II-induced cell senescence, on the contrary, 3-methyladenine aggravated the senescence by weakening autophagy.	3-methyladenine	138-153	angiotensinogen	Homo sapiens	19-25
31986489-6	2020	Moreover, the autophagy inhibitor 3-methyladenine and BECN1 siRNA obviously abolished the antiatherosclerotic and M2 macrophage polarization effects of AsC.	3-methyladenine	34-49	steroid sulfatase	Mus musculus	152-155
31941496-14	2020	Intriguingly, such pro-osteogenic effects induced by CNR2 activation were markedly mitigated by 3-MA.	3-methyladenine	96-100	cannabinoid receptor 2	Homo sapiens	53-57
31892570-8	2020	Finally, the combined treatment of 3-MA or CQ with DDP further up-regulated DDP-induced caspase-3 activity in vitro and exhibited synergistic anti-tumor effects on mice.	3-methyladenine	35-39	caspase 3	Mus musculus	88-97
31696568-6	2020	In contrast, inactivation of autophagy by 3-methyladenine or Bafilomycin A1 could attenuate OPG-mediated inhibition of OC differentiation via the AMPK/mTOR/p70S6K signalling pathway.	3-methyladenine	42-57	TNF receptor superfamily member 11b	Homo sapiens	92-95
31696568-6	2020	In contrast, inactivation of autophagy by 3-methyladenine or Bafilomycin A1 could attenuate OPG-mediated inhibition of OC differentiation via the AMPK/mTOR/p70S6K signalling pathway.	3-methyladenine	42-57	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	146-150
31696568-6	2020	In contrast, inactivation of autophagy by 3-methyladenine or Bafilomycin A1 could attenuate OPG-mediated inhibition of OC differentiation via the AMPK/mTOR/p70S6K signalling pathway.	3-methyladenine	42-57	mechanistic target of rapamycin kinase	Homo sapiens	151-155
31696568-6	2020	In contrast, inactivation of autophagy by 3-methyladenine or Bafilomycin A1 could attenuate OPG-mediated inhibition of OC differentiation via the AMPK/mTOR/p70S6K signalling pathway.	3-methyladenine	42-57	ribosomal protein S6 kinase B1	Homo sapiens	156-162
33023313-11	2020	SPRED2 overexpression increased cell proliferation, invasion, migration, and EMT by promoting autophagy, and the effects could be inhibited by 3-MA.	3-methyladenine	143-147	sprouty related EVH1 domain containing 2	Homo sapiens	0-6
32031067-0	2020	3-methyladenine inhibits procollagen-1 and fibronectin expression in dermal fibroblasts independent of autophagy.	3-methyladenine	0-15	fibronectin 1	Homo sapiens	43-54
32031067-6	2020	RESULTS: Only 3-MA, but not other chemical compounds or autophagy-related gene-targeting siRNA, inhibited the transcription of procollagen-1- and fibronectin-encoding genes.	3-methyladenine	14-18	fibronectin 1	Homo sapiens	146-157
32031067-7	2020	Further, 3-MA did not affect the activation of regulatory Smads, but inhibited the interaction between Smad3 with p300.	3-methyladenine	9-13	SMAD family member 3	Homo sapiens	103-108
32031067-7	2020	Further, 3-MA did not affect the activation of regulatory Smads, but inhibited the interaction between Smad3 with p300.	3-methyladenine	9-13	E1A binding protein p300	Homo sapiens	114-118
32031067-8	2020	Moreover, 3-MA treatment increased the phosphorylation of cAMP response element-binding protein (CREB); however, CREB knock-down did not recover 3-MA-induced procollagen-1 and fibronectin downregulation.	3-methyladenine	10-14	cAMP responsive element binding protein 1	Homo sapiens	58-95
32031067-8	2020	Moreover, 3-MA treatment increased the phosphorylation of cAMP response element-binding protein (CREB); however, CREB knock-down did not recover 3-MA-induced procollagen-1 and fibronectin downregulation.	3-methyladenine	10-14	cAMP responsive element binding protein 1	Homo sapiens	97-101
32031067-9	2020	CONCLUSION: We revealed that 3-MA might inhibit procollagen-1 and fibronectin synthesis in an autophagy-independent manner by interfering with the binding between Smad3 and p300.	3-methyladenine	29-33	fibronectin 1	Homo sapiens	66-77
32031067-9	2020	CONCLUSION: We revealed that 3-MA might inhibit procollagen-1 and fibronectin synthesis in an autophagy-independent manner by interfering with the binding between Smad3 and p300.	3-methyladenine	29-33	SMAD family member 3	Homo sapiens	163-168
32031067-9	2020	CONCLUSION: We revealed that 3-MA might inhibit procollagen-1 and fibronectin synthesis in an autophagy-independent manner by interfering with the binding between Smad3 and p300.	3-methyladenine	29-33	E1A binding protein p300	Homo sapiens	173-177
33155911-16	2020	The ratios of LC3-II to LC3-Iwere significantly lower in the 3-MA treated OGD group than in the non-3-MA treated OGD group (p<0.05).	3-methyladenine	61-65	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	14-17
33155911-16	2020	The ratios of LC3-II to LC3-Iwere significantly lower in the 3-MA treated OGD group than in the non-3-MA treated OGD group (p<0.05).	3-methyladenine	61-65	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	24-27
31806570-6	2020	Then we observed that autophagy inhibitor 3-methyladenine (3-MA) but not proteasome inhibitor MG-132 (MG) could block GW-induced HMGB1 degradation, which indicated that the autophagy-lysosome but not the ubiquitination pathway was involved in this process.	3-methyladenine	42-57	high mobility group box 1	Homo sapiens	129-134
31806570-6	2020	Then we observed that autophagy inhibitor 3-methyladenine (3-MA) but not proteasome inhibitor MG-132 (MG) could block GW-induced HMGB1 degradation, which indicated that the autophagy-lysosome but not the ubiquitination pathway was involved in this process.	3-methyladenine	59-63	high mobility group box 1	Homo sapiens	129-134
33202415-6	2020	The results show that 3-MA has a significant inhibitory effect on ATG12 in THP-1 cells; on the contrary, the expression of ATG12 was upreg-ulated in THP-1 cells that were treated with rapamycin.	3-methyladenine	22-26	autophagy related 12	Homo sapiens	66-71
33202415-6	2020	The results show that 3-MA has a significant inhibitory effect on ATG12 in THP-1 cells; on the contrary, the expression of ATG12 was upreg-ulated in THP-1 cells that were treated with rapamycin.	3-methyladenine	22-26	autophagy related 12	Homo sapiens	123-128
31206674-6	2020	We showed that 3-MA treatment decreases the number of eosinophils, eosinophil peroxidase (EPO) activity, goblet cells hyperplasia, proinflammatory cytokines, and nuclear factor kappa B (NFkappaB) p65 immunocontent in the lung.	3-methyladenine	15-19	eosinophil peroxidase	Mus musculus	67-88
31206674-6	2020	We showed that 3-MA treatment decreases the number of eosinophils, eosinophil peroxidase (EPO) activity, goblet cells hyperplasia, proinflammatory cytokines, and nuclear factor kappa B (NFkappaB) p65 immunocontent in the lung.	3-methyladenine	15-19	eosinophil peroxidase	Mus musculus	90-93
31206674-6	2020	We showed that 3-MA treatment decreases the number of eosinophils, eosinophil peroxidase (EPO) activity, goblet cells hyperplasia, proinflammatory cytokines, and nuclear factor kappa B (NFkappaB) p65 immunocontent in the lung.	3-methyladenine	15-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	162-184
31206674-6	2020	We showed that 3-MA treatment decreases the number of eosinophils, eosinophil peroxidase (EPO) activity, goblet cells hyperplasia, proinflammatory cytokines, and nuclear factor kappa B (NFkappaB) p65 immunocontent in the lung.	3-methyladenine	15-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	186-194
31206674-6	2020	We showed that 3-MA treatment decreases the number of eosinophils, eosinophil peroxidase (EPO) activity, goblet cells hyperplasia, proinflammatory cytokines, and nuclear factor kappa B (NFkappaB) p65 immunocontent in the lung.	3-methyladenine	15-19	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	196-199
31729056-14	2020	Furthermore, treatment with 3-MA decreased the expression of p-AMPK and induced the phosphorylation of mTOR in the presence of JWH-133 stimulation in cystitis model.	3-methyladenine	28-32	mechanistic target of rapamycin kinase	Mus musculus	103-107
31859114-7	2020	Transwell assay show CXCR4 overexpression promote the invasion of TE-1 cells and was attenuated by autophagy inhibitor 3-Methyladenine.On the contrary, invasion cell numbers decreased in siR-CXCR4 group and was rescued by autophagy inducer Rapamycin.	3-methyladenine	119-134	C-X-C motif chemokine receptor 4	Homo sapiens	21-26
31554002-9	2020	3-methyladenine promoted cell viability and ZO-1 expression, down-regulated Beclin-1 and atg5 expression, while Rapamycin (Rap) had an opposite effect.	3-methyladenine	0-15	tight junction protein 1	Mus musculus	44-48
31554002-9	2020	3-methyladenine promoted cell viability and ZO-1 expression, down-regulated Beclin-1 and atg5 expression, while Rapamycin (Rap) had an opposite effect.	3-methyladenine	0-15	beclin 1, autophagy related	Mus musculus	76-84
31554002-9	2020	3-methyladenine promoted cell viability and ZO-1 expression, down-regulated Beclin-1 and atg5 expression, while Rapamycin (Rap) had an opposite effect.	3-methyladenine	0-15	autophagy related 5	Mus musculus	89-93
31881006-8	2019	MIF rejuvenated aged MSCs by activating autophagy, an effect largely reversed by the autophagy inhibitor 3-methyladenine.	3-methyladenine	105-120	macrophage migration inhibitory factor	Homo sapiens	0-3
31949972-7	2019	We found that postconditioning with dexmedetomidine and 3-methyladenine (3MA, an autophagy inhibitor) increased the cell survival meanwhile reduced the production of autophagic vesicles and the expression of LC3 and Beclin 1.	3-methyladenine	56-71	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	208-211
31949972-7	2019	We found that postconditioning with dexmedetomidine and 3-methyladenine (3MA, an autophagy inhibitor) increased the cell survival meanwhile reduced the production of autophagic vesicles and the expression of LC3 and Beclin 1.	3-methyladenine	56-71	beclin 1	Homo sapiens	216-224
31949972-7	2019	We found that postconditioning with dexmedetomidine and 3-methyladenine (3MA, an autophagy inhibitor) increased the cell survival meanwhile reduced the production of autophagic vesicles and the expression of LC3 and Beclin 1.	3-methyladenine	73-76	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	208-211
31949972-7	2019	We found that postconditioning with dexmedetomidine and 3-methyladenine (3MA, an autophagy inhibitor) increased the cell survival meanwhile reduced the production of autophagic vesicles and the expression of LC3 and Beclin 1.	3-methyladenine	73-76	beclin 1	Homo sapiens	216-224
30894058-3	2019	We found that the number of autophagic cells and multinucleated osteoclasts were significantly decreased in presence of 3-MA, GGTI298, and KLF2 overexpressed cells indicating involvement of KLF2 in these processes.	3-methyladenine	120-124	Kruppel-like factor 2 (lung)	Mus musculus	190-194
30894058-7	2019	Moreover, 3-MA and GGTI298 both reduced myeloid cell proliferation concomitantly upregulating senescence-related molecules (CDKN1A/p21 and CDKN1B/p27kip1).	3-methyladenine	10-14	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	124-130
30894058-7	2019	Moreover, 3-MA and GGTI298 both reduced myeloid cell proliferation concomitantly upregulating senescence-related molecules (CDKN1A/p21 and CDKN1B/p27kip1).	3-methyladenine	10-14	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	131-134
30894058-7	2019	Moreover, 3-MA and GGTI298 both reduced myeloid cell proliferation concomitantly upregulating senescence-related molecules (CDKN1A/p21 and CDKN1B/p27kip1).	3-methyladenine	10-14	cyclin-dependent kinase inhibitor 1B	Mus musculus	139-145
30894058-7	2019	Moreover, 3-MA and GGTI298 both reduced myeloid cell proliferation concomitantly upregulating senescence-related molecules (CDKN1A/p21 and CDKN1B/p27kip1).	3-methyladenine	10-14	cyclin-dependent kinase inhibitor 1B	Mus musculus	146-153
31446166-7	2019	Overexpression of FAM134B in 3 T3-L1 preadipocytes promoted autophagy and differentiation, while the effect could be inhibited after treatment with autophagyinhibitors, 3-methyladenine (3-MA).	3-methyladenine	169-184	reticulophagy regulator 1	Mus musculus	18-25
31446166-7	2019	Overexpression of FAM134B in 3 T3-L1 preadipocytes promoted autophagy and differentiation, while the effect could be inhibited after treatment with autophagyinhibitors, 3-methyladenine (3-MA).	3-methyladenine	186-190	reticulophagy regulator 1	Mus musculus	18-25
31634464-12	2019	Moreover, the expression of LC3-II and beclin1 proteins were greatly reduced and the expression of p62 protein was ascended after intervention with 3-MA in ACY1215 group.	3-methyladenine	148-152	nucleoporin 62	Mus musculus	99-102
31578585-12	2019	Furthermore, Parkin silencing or treatment with 3-methyladenine (3-MA, an autophagy inhibitor) promoted the apoptosis of APE1-overexpressing A549 cells, indicating that Parkin-mediated mitophagy plays an important role in the APE1-induced cisplatin resistance of A549 cells.	3-methyladenine	48-63	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	121-125
31578585-12	2019	Furthermore, Parkin silencing or treatment with 3-methyladenine (3-MA, an autophagy inhibitor) promoted the apoptosis of APE1-overexpressing A549 cells, indicating that Parkin-mediated mitophagy plays an important role in the APE1-induced cisplatin resistance of A549 cells.	3-methyladenine	48-63	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	226-230
31578585-12	2019	Furthermore, Parkin silencing or treatment with 3-methyladenine (3-MA, an autophagy inhibitor) promoted the apoptosis of APE1-overexpressing A549 cells, indicating that Parkin-mediated mitophagy plays an important role in the APE1-induced cisplatin resistance of A549 cells.	3-methyladenine	65-69	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	121-125
31578585-12	2019	Furthermore, Parkin silencing or treatment with 3-methyladenine (3-MA, an autophagy inhibitor) promoted the apoptosis of APE1-overexpressing A549 cells, indicating that Parkin-mediated mitophagy plays an important role in the APE1-induced cisplatin resistance of A549 cells.	3-methyladenine	65-69	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	226-230
31852648-9	2019	Treatment with 3-MA alone did not obviously affect HeLa cell apoptosis, but in cells with Golph3 knockdown, 3-MA significantly enhanced paclitaxel-induced apoptosis (P>0.01).	3-methyladenine	108-112	golgi phosphoprotein 3	Homo sapiens	90-96
31740658-7	2019	Our studies also revealed that FGF21 administration leads to an upregulation of autophagy, and the beneficial effects of FGF21 were reversed by 3-methyladenine (3MA), which is a well-known inhibitor of autophagy, suggesting that autophagy plays a central role in FGF21"s therapeutic benefit on skin flap survival.	3-methyladenine	144-159	fibroblast growth factor 21	Rattus norvegicus	121-126
31740658-7	2019	Our studies also revealed that FGF21 administration leads to an upregulation of autophagy, and the beneficial effects of FGF21 were reversed by 3-methyladenine (3MA), which is a well-known inhibitor of autophagy, suggesting that autophagy plays a central role in FGF21"s therapeutic benefit on skin flap survival.	3-methyladenine	144-159	fibroblast growth factor 21	Rattus norvegicus	121-126
31740658-7	2019	Our studies also revealed that FGF21 administration leads to an upregulation of autophagy, and the beneficial effects of FGF21 were reversed by 3-methyladenine (3MA), which is a well-known inhibitor of autophagy, suggesting that autophagy plays a central role in FGF21"s therapeutic benefit on skin flap survival.	3-methyladenine	161-164	fibroblast growth factor 21	Rattus norvegicus	31-36
31740658-7	2019	Our studies also revealed that FGF21 administration leads to an upregulation of autophagy, and the beneficial effects of FGF21 were reversed by 3-methyladenine (3MA), which is a well-known inhibitor of autophagy, suggesting that autophagy plays a central role in FGF21"s therapeutic benefit on skin flap survival.	3-methyladenine	161-164	fibroblast growth factor 21	Rattus norvegicus	121-126
31740658-7	2019	Our studies also revealed that FGF21 administration leads to an upregulation of autophagy, and the beneficial effects of FGF21 were reversed by 3-methyladenine (3MA), which is a well-known inhibitor of autophagy, suggesting that autophagy plays a central role in FGF21"s therapeutic benefit on skin flap survival.	3-methyladenine	161-164	fibroblast growth factor 21	Rattus norvegicus	121-126
31421130-9	2019	Furthermore, autophagy inhibitor 3-methyladenine (3-MA) partly abolished the neuroprotection induced by NMNAT1 overexpression.	3-methyladenine	33-48	nicotinamide nucleotide adenylyltransferase 1	Rattus norvegicus	104-110
31421130-9	2019	Furthermore, autophagy inhibitor 3-methyladenine (3-MA) partly abolished the neuroprotection induced by NMNAT1 overexpression.	3-methyladenine	50-54	nicotinamide nucleotide adenylyltransferase 1	Rattus norvegicus	104-110
31827702-7	2019	Cotreatment with the autophagy inhibitor (3-methyladenine, LY294002, or chloroquine) resulted in a significant enhancement of quercetin-induced BAK activation and subsequently the mitochondrial damage-mediated apoptosis pathway by augmenting the downregulation of BAG3 and MCL-1 levels in J/Neo cells.	3-methyladenine	42-57	BAG cochaperone 3	Homo sapiens	264-268
31827702-7	2019	Cotreatment with the autophagy inhibitor (3-methyladenine, LY294002, or chloroquine) resulted in a significant enhancement of quercetin-induced BAK activation and subsequently the mitochondrial damage-mediated apoptosis pathway by augmenting the downregulation of BAG3 and MCL-1 levels in J/Neo cells.	3-methyladenine	42-57	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	273-278
31592908-4	2019	The normal human chondrocyte pre-treated with rapamycin or 3-methyladenine, treated with interleukin-1beta (IL-1beta).	3-methyladenine	59-74	interleukin 1 beta	Homo sapiens	89-106
31592908-4	2019	The normal human chondrocyte pre-treated with rapamycin or 3-methyladenine, treated with interleukin-1beta (IL-1beta).	3-methyladenine	59-74	interleukin 1 beta	Homo sapiens	108-116
30982980-6	2019	Treatment with adiponectin or 3-methyladenine (3-MA, an autophagy inhibitor) increased cell viability and inhibited cell migration and tube formation.	3-methyladenine	47-51	adiponectin, C1Q and collagen domain containing	Macaca mulatta	15-26
30982980-9	2019	Treatment with adiponectin or 3-MA inhibited autophagy by promoting the expression of p-PI3K, p-AKT, and p-mTOR when compared with the high-glucose group.	3-methyladenine	30-34	mechanistic target of rapamycin kinase	Macaca mulatta	107-111
31412315-12	2019	After treated with the autophagy inhibitor 3-MA in HUVEC, the originally damaged cell tube formation ability and VEGFA expression were repaired.	3-methyladenine	43-47	vascular endothelial growth factor A	Mus musculus	113-118
31277013-11	2019	On the contrary, pretreatment with 3-methyladenine significantly attenuated intestinal injury and autophagy level and upregulated expression of p-mTOR/mTOR.	3-methyladenine	35-50	mechanistic target of rapamycin kinase	Homo sapiens	146-150
31277013-11	2019	On the contrary, pretreatment with 3-methyladenine significantly attenuated intestinal injury and autophagy level and upregulated expression of p-mTOR/mTOR.	3-methyladenine	35-50	mechanistic target of rapamycin kinase	Homo sapiens	151-155
31499136-7	2019	The autophagy inhibitor 3- methyladenine (3-MA) significantly blocked SPARC-induced phenotypic modulation of HBVSMCs.	3-methyladenine	24-40	secreted protein acidic and cysteine rich	Homo sapiens	70-75
31499136-7	2019	The autophagy inhibitor 3- methyladenine (3-MA) significantly blocked SPARC-induced phenotypic modulation of HBVSMCs.	3-methyladenine	42-46	secreted protein acidic and cysteine rich	Homo sapiens	70-75
31352855-11	2019	In vitro, HG and 3-MA reduce the numbers of autophagosome of macrophages to inhibit autophagy level with decrease expression of LC3 and Beclin-1, but increase expression of P62, which promote the adhesion and migration capacity of macrophages (p < .05).	3-methyladenine	17-21	annexin A3	Rattus norvegicus	128-131
31352855-11	2019	In vitro, HG and 3-MA reduce the numbers of autophagosome of macrophages to inhibit autophagy level with decrease expression of LC3 and Beclin-1, but increase expression of P62, which promote the adhesion and migration capacity of macrophages (p < .05).	3-methyladenine	17-21	beclin 1	Rattus norvegicus	136-144
31352855-11	2019	In vitro, HG and 3-MA reduce the numbers of autophagosome of macrophages to inhibit autophagy level with decrease expression of LC3 and Beclin-1, but increase expression of P62, which promote the adhesion and migration capacity of macrophages (p < .05).	3-methyladenine	17-21	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	173-176
30407372-11	2019	Finally, suppressing autophagy with 3-MA represses the protein expression of LC3 and Beclin-1 and mitigates burn-induced skeletal muscle wasting.	3-methyladenine	36-40	annexin A3	Rattus norvegicus	77-80
30407372-11	2019	Finally, suppressing autophagy with 3-MA represses the protein expression of LC3 and Beclin-1 and mitigates burn-induced skeletal muscle wasting.	3-methyladenine	36-40	beclin 1	Rattus norvegicus	85-93
31513885-6	2019	After 3-methyladenine (3-MA) treatment, indicators of hepatic injury were observed in ASPP2+/+and ASPP2+/- mice with CCl4 injection.	3-methyladenine	23-27	transformation related protein 53 binding protein 2	Mus musculus	86-91
31513885-6	2019	After 3-methyladenine (3-MA) treatment, indicators of hepatic injury were observed in ASPP2+/+and ASPP2+/- mice with CCl4 injection.	3-methyladenine	23-27	transformation related protein 53 binding protein 2	Mus musculus	98-103
31720552-3	2019	Moreover, 3-MA was capable of upregulating the expression of DON-induced autophagic protein p62 and downregulating the expressions of DON-induced autophagic protein LC3-II and apoptotic protein Bax, suggesting that autophagy is a driving mechanism for this apoptotic induction.	3-methyladenine	10-14	apoptosis regulator BAX	Sus scrofa	194-197
31519861-9	2019	IL-37 significantly decreased inflammation and collagen deposition in bleomycin-exposed mouse lungs, which was reversed by treatment with the autophagy inhibitor 3-methyladenine.	3-methyladenine	162-177	interleukin 37	Homo sapiens	0-5
31517637-13	2019	Moreover, inhibition of autophagy with molecules such as hydroxychloroquine (20 muMu) and 3-methyladenine (5 mM) was identified by the accumulation of p62 and LC3B.	3-methyladenine	90-105	nucleoporin 62	Homo sapiens	151-154
31517637-13	2019	Moreover, inhibition of autophagy with molecules such as hydroxychloroquine (20 muMu) and 3-methyladenine (5 mM) was identified by the accumulation of p62 and LC3B.	3-methyladenine	90-105	microtubule associated protein 1 light chain 3 beta	Homo sapiens	159-163
31807540-12	2019	Moxibustion preconditioning and 3-MA intervention reversed MIRI-induced changes in Beclin 1, Akt, and Bcl-2 expressions.	3-methyladenine	32-36	beclin 1	Rattus norvegicus	83-91
31807540-12	2019	Moxibustion preconditioning and 3-MA intervention reversed MIRI-induced changes in Beclin 1, Akt, and Bcl-2 expressions.	3-methyladenine	32-36	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
31807540-12	2019	Moxibustion preconditioning and 3-MA intervention reversed MIRI-induced changes in Beclin 1, Akt, and Bcl-2 expressions.	3-methyladenine	32-36	BCL2, apoptosis regulator	Rattus norvegicus	102-107
31165943-4	2019	Meanwhile, we observed that the clearance of alpha-Syn by astrocytes was abolished by proteasome inhibitor MG132 and autophagy inhibitor 3-methyladenine (3MA).	3-methyladenine	137-152	synuclein alpha	Homo sapiens	45-54
31165943-4	2019	Meanwhile, we observed that the clearance of alpha-Syn by astrocytes was abolished by proteasome inhibitor MG132 and autophagy inhibitor 3-methyladenine (3MA).	3-methyladenine	154-157	synuclein alpha	Homo sapiens	45-54
31165943-5	2019	We further showed that intracellular alpha-Syn was reduced after ginkgolide B (GB) and bilobalide (BB) treatment, and the decrease was reversed by MG132 and 3MA.	3-methyladenine	157-160	synuclein alpha	Homo sapiens	37-46
31301307-6	2019	RESULTS: SOX2OT overexpression significantly alleviated the HG-induced HPCs injury and induced autophagy, which was abrogated by the autophagy inhibitor 3-MA and SIRT1 knockdown.	3-methyladenine	153-157	SOX2 overlapping transcript	Homo sapiens	9-15
31524953-6	2019	After autophagy was blocked by 3-MA or CQ, the expression of LC3II was significantly increased in 3-MA+ARs group and p62 was significantly decreased in CQ+ARs group.	3-methyladenine	31-35	nucleoporin 62	Homo sapiens	117-120
31220555-5	2019	In addition, autophagy inhibitor 3-MA was used in vitro experiments to observe the influence of autophagy inhibition on the cell protection effect due to GSK-3beta inactivation.	3-methyladenine	33-37	glycogen synthase kinase 3 beta	Rattus norvegicus	154-163
31220555-8	2019	The autophagy inhibitor 3-MA inverted the protective effect of negative regulation of GSK-3beta.	3-methyladenine	24-28	glycogen synthase kinase 3 beta	Rattus norvegicus	86-95
31540489-6	2019	By using the autophagy inhibitor; 3-MA attenuated the effect of how PRFR enhanced TNF-alpha-induced cell death.	3-methyladenine	34-38	tumor necrosis factor	Homo sapiens	82-91
30908929-8	2019	In addition, the ERS inhibitor salubrinal and the autophagy inhibitor 3-methyladenine inhibited the increased migration of L929 cells transfected with the PPP1R13B CRISPR ACT plasmid.	3-methyladenine	70-85	protein phosphatase 1, regulatory subunit 13B	Mus musculus	155-163
31226633-12	2019	We found that autophagy inhibitor 3-MA could revert cell viability and apoptosis of HeLa regulated by circMTO1 and miR-6893 inhibitor.	3-methyladenine	34-38	microRNA 6893	Homo sapiens	115-123
31054884-8	2019	Moreover, inhibition of autophagy by 3-methyladenine markedly attenuated the apoptosis caused by Ang II.	3-methyladenine	37-52	angiotensinogen	Rattus norvegicus	97-103
30683918-8	2019	We found that the 3-methyladenine (3-MA) and Atg7-shRNA enhanced inflammatory responses induced by knockdown of lncRNA-FA2H-2 and overexpression of MLKL.	3-methyladenine	18-33	mixed lineage kinase domain-like	Mus musculus	148-152
30683918-8	2019	We found that the 3-methyladenine (3-MA) and Atg7-shRNA enhanced inflammatory responses induced by knockdown of lncRNA-FA2H-2 and overexpression of MLKL.	3-methyladenine	35-39	mixed lineage kinase domain-like	Mus musculus	148-152
31176046-8	2019	Autophagy inhibitor 3-MA blocked the protective effects of PG in mediating NLRP3 inflammasome and IL-1beta processing.	3-methyladenine	20-24	NLR family pyrin domain containing 3	Homo sapiens	75-80
31176046-8	2019	Autophagy inhibitor 3-MA blocked the protective effects of PG in mediating NLRP3 inflammasome and IL-1beta processing.	3-methyladenine	20-24	interleukin 1 alpha	Homo sapiens	98-106
31054874-11	2019	Additionally, inhibition of autophagy with si-Beclin 1 and 3-Methyladenine significantly ameliorated Cd-induced CHOP expression and cytotoxicity, indicating that autophagy was detrimental in Cd-accumulated ARPE-19 cells, and a positive feedback regulation mechanism may exist between Cd-triggered ER stress and autophagy.	3-methyladenine	59-74	DNA damage inducible transcript 3	Homo sapiens	112-116
31450612-8	2019	We found that Sirt1/FoxO1, activated by the Sirt1 activators resveratrol (RSV) and SRT1720, decreased the secretion of vWF and P-selectin, which can be abolished by the autophagy inhibitor 3-MA.	3-methyladenine	189-193	sirtuin 1	Homo sapiens	14-19
31450612-8	2019	We found that Sirt1/FoxO1, activated by the Sirt1 activators resveratrol (RSV) and SRT1720, decreased the secretion of vWF and P-selectin, which can be abolished by the autophagy inhibitor 3-MA.	3-methyladenine	189-193	forkhead box O1	Homo sapiens	20-25
31450612-8	2019	We found that Sirt1/FoxO1, activated by the Sirt1 activators resveratrol (RSV) and SRT1720, decreased the secretion of vWF and P-selectin, which can be abolished by the autophagy inhibitor 3-MA.	3-methyladenine	189-193	sirtuin 1	Homo sapiens	44-49
31450612-8	2019	We found that Sirt1/FoxO1, activated by the Sirt1 activators resveratrol (RSV) and SRT1720, decreased the secretion of vWF and P-selectin, which can be abolished by the autophagy inhibitor 3-MA.	3-methyladenine	189-193	von Willebrand factor	Homo sapiens	119-122
31450612-8	2019	We found that Sirt1/FoxO1, activated by the Sirt1 activators resveratrol (RSV) and SRT1720, decreased the secretion of vWF and P-selectin, which can be abolished by the autophagy inhibitor 3-MA.	3-methyladenine	189-193	selectin P	Homo sapiens	127-137
31450620-13	2019	Treatment with the autophagy inhibitor 3-MA resulted in a decrease of autophagy markers and collagen in the TGF-beta-treated fibroblasts.	3-methyladenine	39-43	transforming growth factor beta 1	Homo sapiens	108-116
31497222-11	2019	Pretreatment with 3-methyladenine (3-MA) clearly diminished the anti-hypertrophic effects of EndoA2 in ISO-treated NRCMs.	3-methyladenine	18-33	SH3 domain containing GRB2 like 1, endophilin A2	Rattus norvegicus	93-99
31497222-11	2019	Pretreatment with 3-methyladenine (3-MA) clearly diminished the anti-hypertrophic effects of EndoA2 in ISO-treated NRCMs.	3-methyladenine	35-39	SH3 domain containing GRB2 like 1, endophilin A2	Rattus norvegicus	93-99
31497240-4	2019	Treatment with autophagic inhibitor 3-MA, Baf-A1 and PI3K agonist, IGF-1, fully proved our conclusion, as well as uncovered the potential downregulated signaling pathway, PI3K/AKT/mTOR.	3-methyladenine	36-40	insulin like growth factor 1	Homo sapiens	67-72
31497240-4	2019	Treatment with autophagic inhibitor 3-MA, Baf-A1 and PI3K agonist, IGF-1, fully proved our conclusion, as well as uncovered the potential downregulated signaling pathway, PI3K/AKT/mTOR.	3-methyladenine	36-40	AKT serine/threonine kinase 1	Homo sapiens	176-179
31497240-4	2019	Treatment with autophagic inhibitor 3-MA, Baf-A1 and PI3K agonist, IGF-1, fully proved our conclusion, as well as uncovered the potential downregulated signaling pathway, PI3K/AKT/mTOR.	3-methyladenine	36-40	mechanistic target of rapamycin kinase	Homo sapiens	180-184
31116585-6	2019	Since 3-methyladenine (3-MA) enhanced miR193a expression but inhibited PIK3R3 transcription, it appears that 3-MA inhibits autophagy and induces podocyte dedifferentiation via miR193a generation.	3-methyladenine	6-21	microRNA 193a	Homo sapiens	38-45
31116585-6	2019	Since 3-methyladenine (3-MA) enhanced miR193a expression but inhibited PIK3R3 transcription, it appears that 3-MA inhibits autophagy and induces podocyte dedifferentiation via miR193a generation.	3-methyladenine	6-21	phosphoinositide-3-kinase regulatory subunit 3	Homo sapiens	71-77
31116585-6	2019	Since 3-methyladenine (3-MA) enhanced miR193a expression but inhibited PIK3R3 transcription, it appears that 3-MA inhibits autophagy and induces podocyte dedifferentiation via miR193a generation.	3-methyladenine	23-27	microRNA 193a	Homo sapiens	38-45
31116585-6	2019	Since 3-methyladenine (3-MA) enhanced miR193a expression but inhibited PIK3R3 transcription, it appears that 3-MA inhibits autophagy and induces podocyte dedifferentiation via miR193a generation.	3-methyladenine	23-27	phosphoinositide-3-kinase regulatory subunit 3	Homo sapiens	71-77
31116585-6	2019	Since 3-methyladenine (3-MA) enhanced miR193a expression but inhibited PIK3R3 transcription, it appears that 3-MA inhibits autophagy and induces podocyte dedifferentiation via miR193a generation.	3-methyladenine	109-113	phosphoinositide-3-kinase regulatory subunit 3	Homo sapiens	71-77
31116585-6	2019	Since 3-methyladenine (3-MA) enhanced miR193a expression but inhibited PIK3R3 transcription, it appears that 3-MA inhibits autophagy and induces podocyte dedifferentiation via miR193a generation.	3-methyladenine	109-113	microRNA 193a	Homo sapiens	176-183
31116586-6	2019	Inhibiting mTORC1 with everolimus rapidly increased cyclin D1 degradation, whereas 3-methyladenine, chloroquine, and bafilomycin A1, the classic autophagy inhibitors, could attenuate everolimus-induced cyclin D1 degradation.	3-methyladenine	83-98	cyclin D1	Homo sapiens	202-211
31147742-14	2019	The levels of IL-33 in serum and BALF of the RAPA group was significantly increased after LPS was injected as compared with the LPS group; additionally, the levels of IL-33 in serum and BALF of the 3-MA group was significantly reduced after LPS was injected as compared with the LPS group, and that lung injury was ameliorated after 3-MA pretreatment.	3-methyladenine	198-202	interleukin 33	Mus musculus	14-19
31147742-14	2019	The levels of IL-33 in serum and BALF of the RAPA group was significantly increased after LPS was injected as compared with the LPS group; additionally, the levels of IL-33 in serum and BALF of the 3-MA group was significantly reduced after LPS was injected as compared with the LPS group, and that lung injury was ameliorated after 3-MA pretreatment.	3-methyladenine	198-202	interleukin 33	Mus musculus	167-172
31147742-14	2019	The levels of IL-33 in serum and BALF of the RAPA group was significantly increased after LPS was injected as compared with the LPS group; additionally, the levels of IL-33 in serum and BALF of the 3-MA group was significantly reduced after LPS was injected as compared with the LPS group, and that lung injury was ameliorated after 3-MA pretreatment.	3-methyladenine	333-337	interleukin 33	Mus musculus	167-172
30793300-6	2019	Surprisely, irisin supplementation increased LC3II expression and decreased P62 expression, consisted of results of RFP-GFP-LC3B adenovirus transfection, and reduced cardiomyocyte apoptosis, meanwhile, the protection of irisin was reversed by the autophagy inhibitor 3-methyladenine.	3-methyladenine	267-282	fibronectin type III domain containing 5	Homo sapiens	12-18
30793306-8	2019	Both beclin-1 small interfering RNA and 3-methyladenine treatment predominantly mitigated VEGF-A-induced tube formation and migration of HUVECs, but they failed to elicit any notable effect on VEGF-A-increased expression of GRP78/Bip.	3-methyladenine	40-55	vascular endothelial growth factor A	Mus musculus	90-96
31021425-9	2019	OPTN is inhibited by autophagy inhibitors, such as Acteoside and 3-MA and is promoted by the autophagy activator, Rapamycin.	3-methyladenine	65-69	optineurin	Homo sapiens	0-4
31021425-10	2019	Meanwhile, PI3K and AKT are elevated by Acteoside and 3-MA and inhibited by Rapamycin.	3-methyladenine	54-58	AKT serine/threonine kinase 1	Homo sapiens	20-23
31372165-9	2019	Above all, the inhibition of autophagy by 3-MA not only relieved the Malat1-induced cell proliferation but also promoted the Malat1-induced cell apoptosis.	3-methyladenine	42-46	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	69-75
31372165-9	2019	Above all, the inhibition of autophagy by 3-MA not only relieved the Malat1-induced cell proliferation but also promoted the Malat1-induced cell apoptosis.	3-methyladenine	42-46	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	125-131
31396338-13	2019	Blocking autophagy by 3-methyladenine or autophagy-related 7 (Atg7) siRNAs attenuated the inhibitory effect of miR-223 overexpression on foam cell formation.	3-methyladenine	22-37	microRNA 223	Homo sapiens	111-118
30940293-8	2019	We observed that E2-induced pyroptosis was dramatically increased by 3-methyladenine (3-MA) treatment, which was abolished by YVAD-cmk treatment, suggesting that caspase 1-dependent pyroptosis was negatively regulated by autophagy.	3-methyladenine	69-84	caspase 1	Homo sapiens	162-171
30940293-8	2019	We observed that E2-induced pyroptosis was dramatically increased by 3-methyladenine (3-MA) treatment, which was abolished by YVAD-cmk treatment, suggesting that caspase 1-dependent pyroptosis was negatively regulated by autophagy.	3-methyladenine	86-90	caspase 1	Homo sapiens	162-171
30560904-6	2019	Furthermore, experiments using flow cytometry and western blots revealed that Sul reversed the cytotoxic effect stimulated by the autophagy inhibitors 3-methyladenine (3-MA) and chloroquine (CQ), and its cytoprotective effect was almost eliminated when the autophagy-related 5 (Atg5) gene was knocked down.	3-methyladenine	151-166	autophagy related 5	Homo sapiens	257-276
30560904-6	2019	Furthermore, experiments using flow cytometry and western blots revealed that Sul reversed the cytotoxic effect stimulated by the autophagy inhibitors 3-methyladenine (3-MA) and chloroquine (CQ), and its cytoprotective effect was almost eliminated when the autophagy-related 5 (Atg5) gene was knocked down.	3-methyladenine	151-166	autophagy related 5	Homo sapiens	278-282
30560904-6	2019	Furthermore, experiments using flow cytometry and western blots revealed that Sul reversed the cytotoxic effect stimulated by the autophagy inhibitors 3-methyladenine (3-MA) and chloroquine (CQ), and its cytoprotective effect was almost eliminated when the autophagy-related 5 (Atg5) gene was knocked down.	3-methyladenine	168-172	autophagy related 5	Homo sapiens	257-276
30560904-6	2019	Furthermore, experiments using flow cytometry and western blots revealed that Sul reversed the cytotoxic effect stimulated by the autophagy inhibitors 3-methyladenine (3-MA) and chloroquine (CQ), and its cytoprotective effect was almost eliminated when the autophagy-related 5 (Atg5) gene was knocked down.	3-methyladenine	168-172	autophagy related 5	Homo sapiens	278-282
29674007-5	2019	Enhanced mitophagy was observed in Mst1 interfering cardiomyocytes subjected to high glucose treatment using 3-Methyladenine and Chloroquine.	3-methyladenine	109-124	macrophage stimulating 1	Homo sapiens	35-39
31180548-8	2019	Treatment with 3-methyladenine, or the knockdown of Atg5 by specific small interfering RNA to attenuate autophagy significantly enhanced the viability of CD24-overexpressing HCT116 cells, but reduced the viability of CD24-silenced HT29 cells, relative to their controls.	3-methyladenine	15-30	CD24 molecule	Homo sapiens	154-158
30654114-5	2019	While the ischemic rats treated with 3-MA exhibited inhibition of autophagy, which in turn abolished functional recovery as observed in miR-497 antagomir-treated group (p &lt; 0.05).	3-methyladenine	37-41	microRNA 497	Rattus norvegicus	136-143
31056262-12	2019	Furthermore, autophagy activator rapamycin or inhibitor 3-MA partially reversed the down-regulation or up-regulation of SNHG12 effect in OGD/R-inducedSH-SY5Y cell injury, respectively.	3-methyladenine	56-60	small nucleolar RNA host gene 12	Homo sapiens	120-126
31222000-8	2019	ADM also dose-dependently ameliorated LPS-induced pyroptosis by reversing the increased expression of NLRP3, ASC, caspase-1, IL-1beta, IL-18, GSDMD, caspase-3, caspase-7, TUNEL-positive and PI and active caspase-1 double-stained positive rate, DNA fragmentation and LDH concentration, which could be rescued via co-incubation with 3-MA.	3-methyladenine	331-335	adrenomedullin	Rattus norvegicus	0-3
31222000-12	2019	Like rapamycin, ADM dose-dependently enhanced AMPK phosphorylation but reduced mTOR phosphorylation in LPS-induced Leydig cells, which could be rescued via co-incubation with 3-MA.	3-methyladenine	175-179	adrenomedullin	Rattus norvegicus	16-19
31222000-12	2019	Like rapamycin, ADM dose-dependently enhanced AMPK phosphorylation but reduced mTOR phosphorylation in LPS-induced Leydig cells, which could be rescued via co-incubation with 3-MA.	3-methyladenine	175-179	mechanistic target of rapamycin kinase	Rattus norvegicus	79-83
31258533-7	2019	Furthermore, administration of the autophagy inhibitor 3-methyladenine (3-MA) largely decreased the viability and function of CD8+ T cells through inhibiting autophagy, which significantly prolonged graft survival in rats.	3-methyladenine	55-70	CD8a molecule	Homo sapiens	126-129
31258533-7	2019	Furthermore, administration of the autophagy inhibitor 3-methyladenine (3-MA) largely decreased the viability and function of CD8+ T cells through inhibiting autophagy, which significantly prolonged graft survival in rats.	3-methyladenine	72-76	CD8a molecule	Homo sapiens	126-129
30946956-7	2019	In vitro study revealed that LPS-induced SERCA oxidation, autophagy and cardiac dysfunction were abrogated by ALDH2 activator Alda-1, the ER chaperone TUDCA, the autophagy inhibitor 3-MA, or the AMPK inhibitor Compound C. The beneficial effect of Alda-1 against LPS was nullified by AMPK activator AICAR or rapamycin.	3-methyladenine	182-186	aldehyde dehydrogenase 2 family member	Homo sapiens	110-115
30978385-8	2019	The autophagy inhibitor 3-methyladenine (3-MA) partly prevented exacerbation of brain damage induced by ko-TIGAR, whereas the autophagy inducer rapamycin partially abolished the neuroprotective effect of tg-TIGAR.	3-methyladenine	24-39	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	107-112
30978385-8	2019	The autophagy inhibitor 3-methyladenine (3-MA) partly prevented exacerbation of brain damage induced by ko-TIGAR, whereas the autophagy inducer rapamycin partially abolished the neuroprotective effect of tg-TIGAR.	3-methyladenine	41-45	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	107-112
30978385-9	2019	Knockout of TIGAR reduced the levels of phosphorylated mTOR and S6KP70, which were blocked by 3-MA and NADPH after I/R and OGD/R in vivo and in vitro, respectively.	3-methyladenine	94-98	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	12-17
30978385-9	2019	Knockout of TIGAR reduced the levels of phosphorylated mTOR and S6KP70, which were blocked by 3-MA and NADPH after I/R and OGD/R in vivo and in vitro, respectively.	3-methyladenine	94-98	mechanistic target of rapamycin kinase	Mus musculus	55-59
30970265-6	2019	The autophagy inhibitor 3-methyladenine (3-MA) was used to link the anti-inflammatory effects of miRNA-335-5p to autophagy.	3-methyladenine	24-39	microRNA 335	Homo sapiens	97-106
30970265-6	2019	The autophagy inhibitor 3-methyladenine (3-MA) was used to link the anti-inflammatory effects of miRNA-335-5p to autophagy.	3-methyladenine	41-45	microRNA 335	Homo sapiens	97-106
30970265-9	2019	Importantly, treatment of miRNA-335-5p-overexpressing OA chondrocytes with the autophagy inhibitor 3-MA restored the expression of inflammatory mediators.	3-methyladenine	99-103	microRNA 335	Homo sapiens	26-35
30669957-9	2019	Meanwhile, treatment of SPHK1-transfected cells with 3-methyladenine inhibited EMT.	3-methyladenine	53-68	sphingosine kinase 1	Homo sapiens	24-29
30896851-3	2019	We previously reported that in human melanoma and osteosarcoma cells, autophagy inhibitors, such as 3-methyladenine and chloroquine increased the sensitivity to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).	3-methyladenine	100-115	TNF superfamily member 10	Homo sapiens	182-237
30896851-3	2019	We previously reported that in human melanoma and osteosarcoma cells, autophagy inhibitors, such as 3-methyladenine and chloroquine increased the sensitivity to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).	3-methyladenine	100-115	TNF superfamily member 10	Homo sapiens	239-244
30246435-8	2019	Additionally, the expression of growth differentiation factor 9 and transforming growth factor beta1, which regulates follicle activation, was decreased after 3-MA treatment.	3-methyladenine	159-163	growth differentiation factor 9	Mus musculus	32-100
30387123-6	2019	Moreover, suppression of autophagy by 3-methyladenine attenuated the TRPV4-induced osteoclast differentiation.	3-methyladenine	38-53	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	69-74
30873702-8	2019	Compared with the DHA group, the autophagy inhibitor 3-MA significantly inhibited the expressions of activated Caspase-1, a pyroptotic marker proteins.	3-methyladenine	53-57	caspase 1	Homo sapiens	111-120
31014052-3	2019	Western blot was used to detect the expressions of microtubule-associated protein light chain 3 (LC3), p62 and cysteinyl aspartate specific proteinase 3 (caspase-3) after treatment with aspirin, metformin and 3-Methyladenine (3-MA).	3-methyladenine	226-230	caspase 3	Homo sapiens	111-163
31024806-9	2019	The LC3B-II/I ratio was significantly reduced by 3-MA treatment and increased by CQ treatment.	3-methyladenine	49-53	microtubule associated protein 1 light chain 3 beta	Homo sapiens	4-8
31024806-10	2019	The expressions of Beclin-1 and Atg5 were significantly reduced by 3-MA or CQ treatment, while expression of p62 was increased in the 3-MA or CQ treated cells.	3-methyladenine	67-71	beclin 1	Homo sapiens	19-27
31024806-10	2019	The expressions of Beclin-1 and Atg5 were significantly reduced by 3-MA or CQ treatment, while expression of p62 was increased in the 3-MA or CQ treated cells.	3-methyladenine	67-71	autophagy related 5	Homo sapiens	32-36
31024806-10	2019	The expressions of Beclin-1 and Atg5 were significantly reduced by 3-MA or CQ treatment, while expression of p62 was increased in the 3-MA or CQ treated cells.	3-methyladenine	134-138	nucleoporin 62	Homo sapiens	109-112
30850163-7	2019	In presence of RANKL, the autophagy capacity of OCPs and the differentiation from OCPs into mature osteoclasts were significantly enhanced by 1alpha,25-(OH)2D3, while the suppression of autophagy with spautin-1 or 3-MA downregulated the osteoclastogenesis capacity.	3-methyladenine	214-218	TNF superfamily member 11	Homo sapiens	15-20
31080837-8	2019	At last, the autophagy inhibitor 3-MA abolished UCP2 knockdown-afforded cardioprotective effects.	3-methyladenine	33-37	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	48-52
30944299-8	2019	3-MA could reduce the aberrant accumulation of autophagosomes, which alleviates the pancreas damage that was aggravated by increasing miR-155 levels.	3-methyladenine	0-4	microRNA 155	Mus musculus	134-141
31073356-15	2019	In B16F10 cells, the LC3B and melanin contents were reduced by Pc-EE and were restored by the autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	114-129	microtubule-associated protein 1 light chain 3 beta	Mus musculus	21-25
31073356-15	2019	In B16F10 cells, the LC3B and melanin contents were reduced by Pc-EE and were restored by the autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	131-135	microtubule-associated protein 1 light chain 3 beta	Mus musculus	21-25
30737648-9	2019	An inhibitor of autophagy, 3-methyladenine or bafilomycin A1 significantly augmented GD-induced cleavage of caspase-3.	3-methyladenine	27-42	caspase 3	Rattus norvegicus	108-117
30906429-7	2019	3-Methyladenine was then used to inhibit autophagy, which significantly reduced PA-induced ROS generation and blocked the Ca2+/PKCalpha/NOX4 pathway.	3-methyladenine	0-15	protein kinase C alpha	Homo sapiens	127-135
30906429-7	2019	3-Methyladenine was then used to inhibit autophagy, which significantly reduced PA-induced ROS generation and blocked the Ca2+/PKCalpha/NOX4 pathway.	3-methyladenine	0-15	NADPH oxidase 4	Homo sapiens	136-140
30320898-9	2019	The inhibition of autophagy with CQ or 3MA also decreased the expression of TGF-beta1 and p-Smad3.	3-methyladenine	39-42	transforming growth factor beta 1	Homo sapiens	76-85
30320898-9	2019	The inhibition of autophagy with CQ or 3MA also decreased the expression of TGF-beta1 and p-Smad3.	3-methyladenine	39-42	SMAD family member 3	Homo sapiens	92-97
30632514-9	2019	3-Methyladenine and Akt inhibitor IV intervention suppressed the expression of Beclin-1 and phosphorylated-Akt in injured spinal cord tissue and reduced the protective effect of rapamycin on apoptotic neurons.	3-methyladenine	0-15	beclin 1	Rattus norvegicus	79-87
30632514-9	2019	3-Methyladenine and Akt inhibitor IV intervention suppressed the expression of Beclin-1 and phosphorylated-Akt in injured spinal cord tissue and reduced the protective effect of rapamycin on apoptotic neurons.	3-methyladenine	0-15	AKT serine/threonine kinase 1	Rattus norvegicus	107-110
30826457-8	2019	The staining results showed that repeated administration of MDMA increased expression of autophagosome and caused reduction in SERT densities of striatum and frontal cortex, which was ameliorated in the presence of 3-MA.	3-methyladenine	215-219	solute carrier family 6 member 4	Rattus norvegicus	127-131
30826457-9	2019	PET imaging data also revealed that 3-MA could ameliorate MDMA-induced long-term decreased SERT availability in various brain regions of rats.	3-methyladenine	36-40	solute carrier family 6 member 4	Rattus norvegicus	91-95
30703554-8	2019	Overexpression of SUMO1 significantly increased VSMCs proliferation, migration, hypoxia-induced VSMCs dedifferentiation, and autophagy, but these effects were abolished by inhibition of autophagy by 3-MA in aortic VSMCs.	3-methyladenine	199-203	small ubiquitin-like modifier 1	Mus musculus	18-23
31015768-14	2019	Migration/invasion of cells was significantly inhibited by PION@E6, which could be counteracted by pretreatment with 3-MA.	3-methyladenine	117-121	gamma-secretase activating protein	Homo sapiens	59-66
30897708-7	2019	CLE-10 that was pretreated with 3-methyladenine (3-MA) or chloroquine (CQ) weakened the upregulation of the protein expression of p-ULK1, or the downregulation of p62, p-mTOR, and decreased the level of cytotoxicity against MDA-MB-231 cells.	3-methyladenine	32-47	unc-51 like autophagy activating kinase 1	Homo sapiens	132-136
30897708-7	2019	CLE-10 that was pretreated with 3-methyladenine (3-MA) or chloroquine (CQ) weakened the upregulation of the protein expression of p-ULK1, or the downregulation of p62, p-mTOR, and decreased the level of cytotoxicity against MDA-MB-231 cells.	3-methyladenine	32-47	nucleoporin 62	Homo sapiens	163-166
30897708-7	2019	CLE-10 that was pretreated with 3-methyladenine (3-MA) or chloroquine (CQ) weakened the upregulation of the protein expression of p-ULK1, or the downregulation of p62, p-mTOR, and decreased the level of cytotoxicity against MDA-MB-231 cells.	3-methyladenine	32-47	mechanistic target of rapamycin kinase	Homo sapiens	170-174
30897708-7	2019	CLE-10 that was pretreated with 3-methyladenine (3-MA) or chloroquine (CQ) weakened the upregulation of the protein expression of p-ULK1, or the downregulation of p62, p-mTOR, and decreased the level of cytotoxicity against MDA-MB-231 cells.	3-methyladenine	49-53	unc-51 like autophagy activating kinase 1	Homo sapiens	132-136
30897708-7	2019	CLE-10 that was pretreated with 3-methyladenine (3-MA) or chloroquine (CQ) weakened the upregulation of the protein expression of p-ULK1, or the downregulation of p62, p-mTOR, and decreased the level of cytotoxicity against MDA-MB-231 cells.	3-methyladenine	49-53	nucleoporin 62	Homo sapiens	163-166
30897708-7	2019	CLE-10 that was pretreated with 3-methyladenine (3-MA) or chloroquine (CQ) weakened the upregulation of the protein expression of p-ULK1, or the downregulation of p62, p-mTOR, and decreased the level of cytotoxicity against MDA-MB-231 cells.	3-methyladenine	49-53	mechanistic target of rapamycin kinase	Homo sapiens	170-174
30876449-7	2019	More importantly, IRF2 or INPP4B overexpression reversed autophagy inhibitor, 3-methyladenine (3-MA)-induced proliferation-inhibitory and pro-apoptotic effects, while IRF2 or INPP4B silencing overturned the proliferation-promoting and anti-apoptotic effects of autophagy activator rapamycin.	3-methyladenine	78-93	interferon regulatory factor 2	Homo sapiens	18-22
30876449-7	2019	More importantly, IRF2 or INPP4B overexpression reversed autophagy inhibitor, 3-methyladenine (3-MA)-induced proliferation-inhibitory and pro-apoptotic effects, while IRF2 or INPP4B silencing overturned the proliferation-promoting and anti-apoptotic effects of autophagy activator rapamycin.	3-methyladenine	78-93	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	26-32
30876449-7	2019	More importantly, IRF2 or INPP4B overexpression reversed autophagy inhibitor, 3-methyladenine (3-MA)-induced proliferation-inhibitory and pro-apoptotic effects, while IRF2 or INPP4B silencing overturned the proliferation-promoting and anti-apoptotic effects of autophagy activator rapamycin.	3-methyladenine	95-99	interferon regulatory factor 2	Homo sapiens	18-22
30876449-7	2019	More importantly, IRF2 or INPP4B overexpression reversed autophagy inhibitor, 3-methyladenine (3-MA)-induced proliferation-inhibitory and pro-apoptotic effects, while IRF2 or INPP4B silencing overturned the proliferation-promoting and anti-apoptotic effects of autophagy activator rapamycin.	3-methyladenine	95-99	inositol polyphosphate-4-phosphatase type II B	Homo sapiens	26-32
30972165-9	2019	Chemerin significantly increased LC3 and beclin-1 levels, as measured by western blot analysis, while this effect was inhibited by the autophagy inhibitor 3-MA.	3-methyladenine	155-159	retinoic acid receptor responder 2	Rattus norvegicus	0-8
30208760-7	2019	In contrast, the autophagy inhibitor 3-methylademine (3-MA) aggravated the clinical symptoms of EAE in wild-type (WT) and Mir223-deficienct mice.	3-methyladenine	54-58	microRNA 223	Mus musculus	122-128
30587670-10	2019	Interestingly, autophagy inhibitor 3-methyladenine (3-MA) further increased combination-induced cell apoptosis by increasing the levels of active-caspase 9 and Apaf-1.	3-methyladenine	35-50	caspase 9	Homo sapiens	146-155
30587670-10	2019	Interestingly, autophagy inhibitor 3-methyladenine (3-MA) further increased combination-induced cell apoptosis by increasing the levels of active-caspase 9 and Apaf-1.	3-methyladenine	35-50	apoptotic peptidase activating factor 1	Homo sapiens	160-166
30587670-10	2019	Interestingly, autophagy inhibitor 3-methyladenine (3-MA) further increased combination-induced cell apoptosis by increasing the levels of active-caspase 9 and Apaf-1.	3-methyladenine	52-56	caspase 9	Homo sapiens	146-155
30587670-10	2019	Interestingly, autophagy inhibitor 3-methyladenine (3-MA) further increased combination-induced cell apoptosis by increasing the levels of active-caspase 9 and Apaf-1.	3-methyladenine	52-56	apoptotic peptidase activating factor 1	Homo sapiens	160-166
30664197-9	2019	The results indicated that FGF-21 alleviated H/R-induced H9c2 myocardial cell injury and enhanced autophagic flux during H/R, and that this effect was antagonized by co-treatment with 3-methyladenine, an autophagy inhibitor.	3-methyladenine	184-199	fibroblast growth factor 21	Rattus norvegicus	27-33
30747215-9	2019	In addition, inhibition of autophagy by 3-methyladenine significant enhanced the protective effect of miR-101 against LIRI, compared with the IR group (P&lt;0.001).	3-methyladenine	40-55	membrane associated ring-CH-type finger 8	Homo sapiens	102-105
30145832-11	2019	Additionally, cotreatment of NAC with 3-MA significantly attenuated the ROS level and suppressed the cell autophagy.	3-methyladenine	38-42	X-linked Kx blood group	Homo sapiens	29-32
30537209-9	2019	In addition, we also found that 3-MA decreased the expression of LC3A/B and Beclin1, while the JNK inhibitor SP600125 reduced the levels of phosphorylated JNK, LC3A/B and Beclin1.	3-methyladenine	32-36	beclin 1	Rattus norvegicus	76-83
30890503-5	2019	Western blotting and flow cytometry were used to analyze the effect of autophagy on apoptosis of the ATG3-overexpressing cells treated with salinomycin and 3-MA (an autophagy inhibitor).	3-methyladenine	156-160	autophagy related 3	Homo sapiens	101-105
30629952-5	2019	Rapamycin (autophagy agonist) treatment increased autophagy levels and decreased the cytotoxicity caused by T-2 toxin while 3-methyladenine (autophagy inhibitor) treatment reduced autophagy levels and enhanced the cytotoxicity of T-2 toxin, suggesting that autophagy protect primary cardiomyocytes from the cytotoxicity of T-2 toxin.	3-methyladenine	124-139	solute carrier family 25 member 5	Homo sapiens	230-233
30629952-5	2019	Rapamycin (autophagy agonist) treatment increased autophagy levels and decreased the cytotoxicity caused by T-2 toxin while 3-methyladenine (autophagy inhibitor) treatment reduced autophagy levels and enhanced the cytotoxicity of T-2 toxin, suggesting that autophagy protect primary cardiomyocytes from the cytotoxicity of T-2 toxin.	3-methyladenine	124-139	solute carrier family 25 member 5	Homo sapiens	230-233
30918581-11	2019	Using 3-MA, an autophagy inhibitor, the neuroprotective effects of HNK on mitophagy and NLRP3 inflammasome activation were eliminated.	3-methyladenine	6-10	NLR family, pyrin domain containing 3	Mus musculus	88-93
30775803-7	2019	Moreover, blocking autophagy by 3-methyladenine partly attenuated AMPKalpha1-mediated POCD improvement.	3-methyladenine	32-47	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	66-76
30635359-5	2019	Treatment with the autophagosome inhibitor 3MA blocks niclosamide-mediated Frizzled 1 degradation.	3-methyladenine	43-46	frizzled class receptor 1	Homo sapiens	75-85
29486589-7	2019	The autophagy inhibitor 3-methyladenine reduced BLM-induced lung fibrosis and concurrently facilitated NLRP3 inflammasome activation and oxidation in fibroblasts.	3-methyladenine	24-39	NLR family pyrin domain containing 3	Homo sapiens	103-108
30448697-5	2019	Meanwhile, we also confirmed the down-regulation of PD-L1 in osteosarcoma in response to PDT and 3-MA treatment, which significantly inhibited tumor growth in a model of tumor metastasis.	3-methyladenine	97-101	CD274 molecule	Homo sapiens	52-57
30312115-6	2019	Once inhibited the autophagy of hIAPP-INS1 cells by 3-methyladenine for 24 h, resveratrol does not effectively remove hIAPP deposits again, and cannot improve the function of insulin secretion.	3-methyladenine	52-67	islet amyloid polypeptide	Homo sapiens	32-37
30531011-11	2019	However, after inhibition of autophagy signaling with 3-methyladenine, CX3CL1 expression on neurons was obviously increased, whereas Iba-1 and NF-kappaB expression was downregulated; TNF-alpha, IL-6, IL-1beta, and PGE2 levels were decreased; and cerebral edema was obviously mitigated.	3-methyladenine	54-69	C-X3-C motif chemokine ligand 1	Rattus norvegicus	71-77
30692075-7	2019	Pharmacological inhibition of TNF-alpha-induced autophagy by 3-MA significantly decreased the cell viability and increased the apoptosis rate of SCAPs (P &amp;lt; 0.05).	3-methyladenine	61-65	tumor necrosis factor	Homo sapiens	30-39
30679495-12	2019	The autophagy inhibitor 3-MA prevented DN EGFR mice from exhibiting reduced CNS invasion.	3-methyladenine	24-28	epidermal growth factor receptor	Mus musculus	42-46
29769743-9	2019	However, autophagy inhibition by knockdown of autophagy-related gene ATG5 or 3-methyladenine (3-MA) exaggerated aescin-induced apoptosis when TIGAR was knocked down.	3-methyladenine	94-98	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	142-147
31091975-7	2019	Pretreatment of neuro-2a cells with 3-methyladenine, an inhibitor of autophagy, attenuated honokiol-induced cell autophagy, caspase-3 activation, DNA damage and cell apoptosis.	3-methyladenine	36-51	caspase 3	Mus musculus	124-133
30278168-13	2019	3-Methyladenine completely abolished enhancements of the LC3-II/LC3-I ratio and beclin-1 expression induced by antagomiR-204 and inhibited the protective effect on hind-limb motor function.	3-methyladenine	0-15	beclin 1	Rattus norvegicus	80-88
31622062-9	2019	3-MA and LY294002, a pan PI3-kinase inhibitor, further increased Ang II-induced podocyte apoptosis.	3-methyladenine	0-4	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	65-71
30651797-11	2019	After 3-MA treatment the expression levels of Beclin1 and LC3-II/I were decreased, compared with CLP group, but accumulation of p62 occurred, and the degree of renal injury was increased.	3-methyladenine	6-10	beclin 1, autophagy related	Mus musculus	46-53
30651797-11	2019	After 3-MA treatment the expression levels of Beclin1 and LC3-II/I were decreased, compared with CLP group, but accumulation of p62 occurred, and the degree of renal injury was increased.	3-methyladenine	6-10	nucleoporin 62	Mus musculus	128-131
30332528-8	2019	Furthermore, autophagy inhibition by 3-MA significantly decreased protein expression of GRP78, p-PERK, and p-eIF2alpha and increased CHOP, ATF4, and caspase-4, whereas ERS inhibition by 4-PBA led to autophagy suppression.	3-methyladenine	37-41	heat shock protein family A (Hsp70) member 5	Homo sapiens	88-93
30332528-8	2019	Furthermore, autophagy inhibition by 3-MA significantly decreased protein expression of GRP78, p-PERK, and p-eIF2alpha and increased CHOP, ATF4, and caspase-4, whereas ERS inhibition by 4-PBA led to autophagy suppression.	3-methyladenine	37-41	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	97-101
30332528-8	2019	Furthermore, autophagy inhibition by 3-MA significantly decreased protein expression of GRP78, p-PERK, and p-eIF2alpha and increased CHOP, ATF4, and caspase-4, whereas ERS inhibition by 4-PBA led to autophagy suppression.	3-methyladenine	37-41	eukaryotic translation initiation factor 2A	Homo sapiens	109-118
30332528-8	2019	Furthermore, autophagy inhibition by 3-MA significantly decreased protein expression of GRP78, p-PERK, and p-eIF2alpha and increased CHOP, ATF4, and caspase-4, whereas ERS inhibition by 4-PBA led to autophagy suppression.	3-methyladenine	37-41	DNA damage inducible transcript 3	Homo sapiens	133-137
30332528-8	2019	Furthermore, autophagy inhibition by 3-MA significantly decreased protein expression of GRP78, p-PERK, and p-eIF2alpha and increased CHOP, ATF4, and caspase-4, whereas ERS inhibition by 4-PBA led to autophagy suppression.	3-methyladenine	37-41	activating transcription factor 4	Homo sapiens	139-143
30332528-8	2019	Furthermore, autophagy inhibition by 3-MA significantly decreased protein expression of GRP78, p-PERK, and p-eIF2alpha and increased CHOP, ATF4, and caspase-4, whereas ERS inhibition by 4-PBA led to autophagy suppression.	3-methyladenine	37-41	caspase 4	Homo sapiens	149-158
30422312-10	2019	The results showed that 3-MA elicited a significant loss of the protective effect of HSPB8 against MCAO/R-induced neurological defect, Evans blue extravasation, and the loss tight junction proteins, suggesting that the BBB protective role of HSPB8 was, at least in part, mediated through autophagy.	3-methyladenine	24-28	heat shock protein family B (small) member 8	Rattus norvegicus	85-90
30422312-10	2019	The results showed that 3-MA elicited a significant loss of the protective effect of HSPB8 against MCAO/R-induced neurological defect, Evans blue extravasation, and the loss tight junction proteins, suggesting that the BBB protective role of HSPB8 was, at least in part, mediated through autophagy.	3-methyladenine	24-28	heat shock protein family B (small) member 8	Rattus norvegicus	242-247
30448177-9	2018	Lung histopathological changes, W/D ratio, TNF-alpha, IL-1beta and protein content in BALF induced by LPS were effectively ameliorated by H2S and autophagy inhibitor 3-methyladenine.	3-methyladenine	166-181	tumor necrosis factor	Mus musculus	43-52
30448177-9	2018	Lung histopathological changes, W/D ratio, TNF-alpha, IL-1beta and protein content in BALF induced by LPS were effectively ameliorated by H2S and autophagy inhibitor 3-methyladenine.	3-methyladenine	166-181	interleukin 1 beta	Mus musculus	54-62
30399463-8	2018	Vimentin, alpha-SMA, bilayer membrane vesicle structures of autophagosomes, and autophagy related proteins were observed after treatment with lipopolysaccharide (LPS) or 3-methyladenine (3-MA) at 24 h. RESULTS: After MI on 7, 14, and 28 days, Tlr4-/- mice showed that heart tissue fibrosis and expression of alpha-SMA, a marker of myofibroblasts, were decreased compared to WT mice.	3-methyladenine	170-185	vimentin	Mus musculus	0-8
30193956-9	2018	Treatment with 3-MA, an inhibitor of autophagy, abolished the beneficial effects of Mst1 knockout against Ang II-induced cardiac dysfunction.	3-methyladenine	15-19	macrophage stimulating 1 (hepatocyte growth factor-like)	Mus musculus	84-88
30193956-9	2018	Treatment with 3-MA, an inhibitor of autophagy, abolished the beneficial effects of Mst1 knockout against Ang II-induced cardiac dysfunction.	3-methyladenine	15-19	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	106-112
30323152-9	2018	Immunoreactivities for Beclin-1 and light-chain 3B were weaker in the 3-MA group than in the SCI group, indicating that 3-MA inhibits lithium-induced autophagy.	3-methyladenine	70-74	beclin 1	Rattus norvegicus	23-31
30205151-8	2018	In our study, 3-methyladenine (3-MA), an autophagy inhibitor, aggravated NLRP3 inflammasome activation, pyroptosis and decreased cell migration, rapamycin (Rapa), an autophagy inducer, alleviated aforementioned phenomenon under acrolein stress.	3-methyladenine	14-29	NLR family pyrin domain containing 3	Homo sapiens	73-78
30205151-8	2018	In our study, 3-methyladenine (3-MA), an autophagy inhibitor, aggravated NLRP3 inflammasome activation, pyroptosis and decreased cell migration, rapamycin (Rapa), an autophagy inducer, alleviated aforementioned phenomenon under acrolein stress.	3-methyladenine	31-35	NLR family pyrin domain containing 3	Homo sapiens	73-78
30538709-8	2018	Administration of DC32 could inhibit the activation of Akt/mTOR and ERK, and pretreatment of NIH-3T3 cells with the autophagy inhibitor 3-methyladenine (3-MA) attenuated the degradation of Keap1 induced by DC32.	3-methyladenine	136-151	kelch-like ECH-associated protein 1	Mus musculus	189-194
30538709-8	2018	Administration of DC32 could inhibit the activation of Akt/mTOR and ERK, and pretreatment of NIH-3T3 cells with the autophagy inhibitor 3-methyladenine (3-MA) attenuated the degradation of Keap1 induced by DC32.	3-methyladenine	153-157	thymoma viral proto-oncogene 1	Mus musculus	55-58
30538709-8	2018	Administration of DC32 could inhibit the activation of Akt/mTOR and ERK, and pretreatment of NIH-3T3 cells with the autophagy inhibitor 3-methyladenine (3-MA) attenuated the degradation of Keap1 induced by DC32.	3-methyladenine	153-157	kelch-like ECH-associated protein 1	Mus musculus	189-194
30417553-11	2018	In addition, the autophagy pharmacological inhibitor (3-methyladenine, 3-MA) affected the effect of MEG3 overexpression on cell proliferation.	3-methyladenine	54-69	maternally expressed 3	Homo sapiens	100-104
30417553-11	2018	In addition, the autophagy pharmacological inhibitor (3-methyladenine, 3-MA) affected the effect of MEG3 overexpression on cell proliferation.	3-methyladenine	71-75	maternally expressed 3	Homo sapiens	100-104
30293967-3	2018	In the present study, we observed that inhibition of autophagy by 3-methyladenine (3-MA) abolished uric acid-induced differentiation of renal fibroblasts to myofibroblasts and activation of transforming growth factor-beta1 (TGF-beta1), epidermal growth factor receptor (EGFR), and Wnt signaling pathways in cultured renal interstitial fibroblasts.	3-methyladenine	66-81	transforming growth factor beta 1	Homo sapiens	190-222
30293967-3	2018	In the present study, we observed that inhibition of autophagy by 3-methyladenine (3-MA) abolished uric acid-induced differentiation of renal fibroblasts to myofibroblasts and activation of transforming growth factor-beta1 (TGF-beta1), epidermal growth factor receptor (EGFR), and Wnt signaling pathways in cultured renal interstitial fibroblasts.	3-methyladenine	66-81	transforming growth factor beta 1	Homo sapiens	224-233
30293967-3	2018	In the present study, we observed that inhibition of autophagy by 3-methyladenine (3-MA) abolished uric acid-induced differentiation of renal fibroblasts to myofibroblasts and activation of transforming growth factor-beta1 (TGF-beta1), epidermal growth factor receptor (EGFR), and Wnt signaling pathways in cultured renal interstitial fibroblasts.	3-methyladenine	66-81	epidermal growth factor receptor	Homo sapiens	236-268
30293967-3	2018	In the present study, we observed that inhibition of autophagy by 3-methyladenine (3-MA) abolished uric acid-induced differentiation of renal fibroblasts to myofibroblasts and activation of transforming growth factor-beta1 (TGF-beta1), epidermal growth factor receptor (EGFR), and Wnt signaling pathways in cultured renal interstitial fibroblasts.	3-methyladenine	66-81	epidermal growth factor receptor	Homo sapiens	270-274
30293967-3	2018	In the present study, we observed that inhibition of autophagy by 3-methyladenine (3-MA) abolished uric acid-induced differentiation of renal fibroblasts to myofibroblasts and activation of transforming growth factor-beta1 (TGF-beta1), epidermal growth factor receptor (EGFR), and Wnt signaling pathways in cultured renal interstitial fibroblasts.	3-methyladenine	83-87	transforming growth factor beta 1	Homo sapiens	190-222
30293967-3	2018	In the present study, we observed that inhibition of autophagy by 3-methyladenine (3-MA) abolished uric acid-induced differentiation of renal fibroblasts to myofibroblasts and activation of transforming growth factor-beta1 (TGF-beta1), epidermal growth factor receptor (EGFR), and Wnt signaling pathways in cultured renal interstitial fibroblasts.	3-methyladenine	83-87	transforming growth factor beta 1	Homo sapiens	224-233
30293967-3	2018	In the present study, we observed that inhibition of autophagy by 3-methyladenine (3-MA) abolished uric acid-induced differentiation of renal fibroblasts to myofibroblasts and activation of transforming growth factor-beta1 (TGF-beta1), epidermal growth factor receptor (EGFR), and Wnt signaling pathways in cultured renal interstitial fibroblasts.	3-methyladenine	83-87	epidermal growth factor receptor	Homo sapiens	236-268
30293967-3	2018	In the present study, we observed that inhibition of autophagy by 3-methyladenine (3-MA) abolished uric acid-induced differentiation of renal fibroblasts to myofibroblasts and activation of transforming growth factor-beta1 (TGF-beta1), epidermal growth factor receptor (EGFR), and Wnt signaling pathways in cultured renal interstitial fibroblasts.	3-methyladenine	83-87	epidermal growth factor receptor	Homo sapiens	270-274
30260385-9	2018	The induction of apoptosis and Caspase 3 activity by SAC, DADS and DTS were increased by stably knocking down of ATG5 expression with shRNA in RAW264.7 cells or treating with 5 mM 3-MA in primary macrophages.	3-methyladenine	180-184	caspase 3	Mus musculus	31-40
30260385-9	2018	The induction of apoptosis and Caspase 3 activity by SAC, DADS and DTS were increased by stably knocking down of ATG5 expression with shRNA in RAW264.7 cells or treating with 5 mM 3-MA in primary macrophages.	3-methyladenine	180-184	autophagy related 5	Mus musculus	113-117
30251678-7	2018	Autophagy inhibition using 3-methyladenine prevented CaSR-induced TNFalpha production, indicating that autophagy contributes to CaSR-induced inflammation in human preadipocytes.	3-methyladenine	27-42	calcium sensing receptor	Homo sapiens	53-57
30251678-7	2018	Autophagy inhibition using 3-methyladenine prevented CaSR-induced TNFalpha production, indicating that autophagy contributes to CaSR-induced inflammation in human preadipocytes.	3-methyladenine	27-42	tumor necrosis factor	Homo sapiens	66-74
29958907-10	2018	We found that the expression of LC3 was increased after OGD/R which can be further enhanced by H2 and RAP treatment, but treatment with 3-MA was opposite.	3-methyladenine	136-140	annexin A3	Rattus norvegicus	32-35
29958907-12	2018	In addition, the study found H2 and RAP could significantly induce the expression of PINK1 and Parkin in OGD/R neurons which was inhibited by 3-MA.	3-methyladenine	142-146	LDL receptor related protein associated protein 1	Rattus norvegicus	36-39
29958907-12	2018	In addition, the study found H2 and RAP could significantly induce the expression of PINK1 and Parkin in OGD/R neurons which was inhibited by 3-MA.	3-methyladenine	142-146	PTEN induced kinase 1	Rattus norvegicus	85-90
30318510-5	2018	RESULTS: C1A potently resolved autophagy substrates induced by 3-methyladenine and chloroquine.	3-methyladenine	63-78	endogenous retrovirus group K member 1	Homo sapiens	9-12
30155758-9	2018	Curcumin has similar effects with 3-MA, in which curcumin inhibited NF-kappaB by preventing the translocation of NF-kappaB p65.	3-methyladenine	34-38	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	68-77
30155758-9	2018	Curcumin has similar effects with 3-MA, in which curcumin inhibited NF-kappaB by preventing the translocation of NF-kappaB p65.	3-methyladenine	34-38	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	113-122
30155758-9	2018	Curcumin has similar effects with 3-MA, in which curcumin inhibited NF-kappaB by preventing the translocation of NF-kappaB p65.	3-methyladenine	34-38	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	123-126
30194633-8	2018	Inhibiting autophagy with 3-MA attenuated the PA and ER stress-induced cell apoptosis and the apoptosis-related gene expression (Caspase 3 and BAX), but seemed to have no obvious effects on ER stress, although the CHOP expression was downregulated.	3-methyladenine	26-30	caspase 3	Homo sapiens	129-138
30194633-8	2018	Inhibiting autophagy with 3-MA attenuated the PA and ER stress-induced cell apoptosis and the apoptosis-related gene expression (Caspase 3 and BAX), but seemed to have no obvious effects on ER stress, although the CHOP expression was downregulated.	3-methyladenine	26-30	BCL2 associated X, apoptosis regulator	Homo sapiens	143-146
30221728-5	2018	Treatment with pristimerin dose-dependently induced an increase of light chain 3B (LC3-II), whereas autophagy inhibitor 3-methyladenine (3-MA) inhibited pristimerin-induced LC3-II accumulation and cytotoxic effects.	3-methyladenine	120-135	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	173-176
30221728-5	2018	Treatment with pristimerin dose-dependently induced an increase of light chain 3B (LC3-II), whereas autophagy inhibitor 3-methyladenine (3-MA) inhibited pristimerin-induced LC3-II accumulation and cytotoxic effects.	3-methyladenine	137-141	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	173-176
30221728-9	2018	Treatment with 3-MA inhibited LC3-II accumulation and cell death induced by a combination of paclitaxel and pristimerin.	3-methyladenine	15-19	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	30-33
30317896-7	2018	3-MA administration reduced the accumulation of autophagic vacuoles, the expression of LC3B-II and p62, followed by a significant attenuation of histopathological changes, inflammation, and oxidative stress.	3-methyladenine	0-4	nucleoporin 62	Homo sapiens	99-102
30378150-5	2018	Furthermore, incubation of MFCs with PAH also increased autophagy as determined by monodansylcadaverine (MDC) staining, which was reversed by AMPK inhibitor compound C. PAH further decreased MFCs cell survival, which was abolished by compound C or autophagy inhibitor 3-Methyladenine (3-MA).	3-methyladenine	268-283	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	142-146
30378150-5	2018	Furthermore, incubation of MFCs with PAH also increased autophagy as determined by monodansylcadaverine (MDC) staining, which was reversed by AMPK inhibitor compound C. PAH further decreased MFCs cell survival, which was abolished by compound C or autophagy inhibitor 3-Methyladenine (3-MA).	3-methyladenine	285-289	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	142-146
30337735-9	2018	While 3-MA, an early autophagy inhibitor, reduced the ST-induced cleavage of poly (ADP-ribose) polymerase-1 (PARP-1), a substrate of caspase 3/7 and often used marker of caspase-dependent apoptosis, CQ promoted the ST-dependent PARP-1 cleavage, indicating that the early and late autophagy functioned differentially on the ST-activated apoptotic process.	3-methyladenine	6-10	poly(ADP-ribose) polymerase 1	Homo sapiens	77-107
30337735-9	2018	While 3-MA, an early autophagy inhibitor, reduced the ST-induced cleavage of poly (ADP-ribose) polymerase-1 (PARP-1), a substrate of caspase 3/7 and often used marker of caspase-dependent apoptosis, CQ promoted the ST-dependent PARP-1 cleavage, indicating that the early and late autophagy functioned differentially on the ST-activated apoptotic process.	3-methyladenine	6-10	poly(ADP-ribose) polymerase 1	Homo sapiens	109-115
30337735-9	2018	While 3-MA, an early autophagy inhibitor, reduced the ST-induced cleavage of poly (ADP-ribose) polymerase-1 (PARP-1), a substrate of caspase 3/7 and often used marker of caspase-dependent apoptosis, CQ promoted the ST-dependent PARP-1 cleavage, indicating that the early and late autophagy functioned differentially on the ST-activated apoptotic process.	3-methyladenine	6-10	caspase 3	Homo sapiens	133-142
30337735-9	2018	While 3-MA, an early autophagy inhibitor, reduced the ST-induced cleavage of poly (ADP-ribose) polymerase-1 (PARP-1), a substrate of caspase 3/7 and often used marker of caspase-dependent apoptosis, CQ promoted the ST-dependent PARP-1 cleavage, indicating that the early and late autophagy functioned differentially on the ST-activated apoptotic process.	3-methyladenine	6-10	poly(ADP-ribose) polymerase 1	Homo sapiens	228-234
30315711-13	2018	The pretreatment of 3-methyladenine (3-MA) reversed the reduction of Caspase-3 caused by ADMSCs, showing that the antiapoptotic effect was associated with autophagy inducing.	3-methyladenine	20-35	caspase 3	Rattus norvegicus	69-78
30315711-13	2018	The pretreatment of 3-methyladenine (3-MA) reversed the reduction of Caspase-3 caused by ADMSCs, showing that the antiapoptotic effect was associated with autophagy inducing.	3-methyladenine	37-41	caspase 3	Rattus norvegicus	69-78
30315154-4	2018	Inhibition of autophagy with 3-methyl adenine or chloroquine has a remarkable synergistic effect on TNP-1-mediated PTT in triple-negative (4T1), drug-resistant (MCF7/MDR) and patient-derived breast cancer models, achieving a level of efficacy unattainable with TNP-2, the identically-shaped CuPd nanoparticles that have a higher photothermal conversion efficiency but no autophagy-inducing activity.	3-methyladenine	29-45	transition protein 1	Homo sapiens	100-105
30315154-4	2018	Inhibition of autophagy with 3-methyl adenine or chloroquine has a remarkable synergistic effect on TNP-1-mediated PTT in triple-negative (4T1), drug-resistant (MCF7/MDR) and patient-derived breast cancer models, achieving a level of efficacy unattainable with TNP-2, the identically-shaped CuPd nanoparticles that have a higher photothermal conversion efficiency but no autophagy-inducing activity.	3-methyladenine	29-45	transition protein 2	Homo sapiens	261-266
30323558-11	2018	The maturation of microtubule-associated protein 1A/1B-LC3B indicated the activation of autophagy potentially through PI3K/Akt/mTOR pathway, and inhibition of autophagy by 3-methyladenine decreased the apoptotic cell ratio.	3-methyladenine	172-187	AKT serine/threonine kinase 1	Homo sapiens	123-126
30416863-13	2018	The inhibitory effect of URI silencing on mTOR and p70S6K phosphorylation was antagonized by the autophagy inhibitor 3-methyladenine.	3-methyladenine	117-132	URI1 prefoldin like chaperone	Homo sapiens	25-28
30416863-13	2018	The inhibitory effect of URI silencing on mTOR and p70S6K phosphorylation was antagonized by the autophagy inhibitor 3-methyladenine.	3-methyladenine	117-132	mechanistic target of rapamycin kinase	Homo sapiens	42-46
30416863-13	2018	The inhibitory effect of URI silencing on mTOR and p70S6K phosphorylation was antagonized by the autophagy inhibitor 3-methyladenine.	3-methyladenine	117-132	ribosomal protein S6 kinase B1	Homo sapiens	51-57
29992400-4	2018	Moreover, we found that the inhibition of autophagy by 3-methyladenine, an autophagy inhibitor, enhanced Tox N-induced apoptotic cell death.	3-methyladenine	55-70	thymocyte selection associated high mobility group box	Homo sapiens	105-108
29979351-6	2018	However, using 3-methyladenine (3-MA) abolished the role of CTRP9 by inhibiting autophagy.	3-methyladenine	15-30	C1q and TNF related 9	Homo sapiens	60-65
29979351-6	2018	However, using 3-methyladenine (3-MA) abolished the role of CTRP9 by inhibiting autophagy.	3-methyladenine	32-36	C1q and TNF related 9	Homo sapiens	60-65
30031129-7	2018	Of note, the blockade of autophagy by 3-Methyladenine (3-MA) abrogated the inhibition of cell migration and invasion by over-expressing AIM2, indicated that AIM2 suppressed the malignant behaviors of renal carcinoma by enhancing the induction of autophagy.	3-methyladenine	38-53	absent in melanoma 2	Homo sapiens	136-140
30031129-7	2018	Of note, the blockade of autophagy by 3-Methyladenine (3-MA) abrogated the inhibition of cell migration and invasion by over-expressing AIM2, indicated that AIM2 suppressed the malignant behaviors of renal carcinoma by enhancing the induction of autophagy.	3-methyladenine	55-59	absent in melanoma 2	Homo sapiens	136-140
30031129-7	2018	Of note, the blockade of autophagy by 3-Methyladenine (3-MA) abrogated the inhibition of cell migration and invasion by over-expressing AIM2, indicated that AIM2 suppressed the malignant behaviors of renal carcinoma by enhancing the induction of autophagy.	3-methyladenine	55-59	absent in melanoma 2	Homo sapiens	157-161
30031129-8	2018	Furthermore, 3-MA abolished the prevention of tumor growth on nude mouse established by AIM2-OSRC-2 cells.	3-methyladenine	13-17	absent in melanoma 2	Mus musculus	88-92
30031129-8	2018	Furthermore, 3-MA abolished the prevention of tumor growth on nude mouse established by AIM2-OSRC-2 cells.	3-methyladenine	13-17	RB transcriptional corepressor 1	Homo sapiens	93-97
29928874-8	2018	Whereas the combined use of E2 and 3-MA led to a dramatic decrease in autophagy, while aberrantly elevated expression levels of apoptotic and MMPs.	3-methyladenine	35-39	matrix metallopeptidase 3	Rattus norvegicus	142-146
30254716-11	2018	Both Sirt3-siRNA and autophagy inhibitor 3-MA partially abolished the beneficial effects of melatonin on mitoROS clearance and NLRP3 inflammasome activation, indicating the crucial role of Sirt3-mediated mitophagy.	3-methyladenine	41-45	NLR family, pyrin domain containing 3	Mus musculus	127-132
30254716-11	2018	Both Sirt3-siRNA and autophagy inhibitor 3-MA partially abolished the beneficial effects of melatonin on mitoROS clearance and NLRP3 inflammasome activation, indicating the crucial role of Sirt3-mediated mitophagy.	3-methyladenine	41-45	sirtuin 3	Mus musculus	189-194
30170968-5	2018	In vivo modulation of mTOR and autophagy was achieved by using AZD8055, rapamycin and 3-methyladenine.	3-methyladenine	86-101	mechanistic target of rapamycin kinase	Homo sapiens	22-26
29613836-13	2018	NAC or 3-MA pretreatments inhibited IL-17-mediated cell apoptosis.	3-methyladenine	7-11	interleukin 17A	Mus musculus	36-41
30056017-9	2018	The effects of autophagy inhibition of 3-MA on the expressions of LC3B, Atg5, and Beclin-1 were investigated by real-time PCR and Western blotting, as well as the alpha-SMA, TGF-beta1, ColI, Col III, FN, MMP-2, MMP-13, TIMP-1 and TIMP-2.	3-methyladenine	39-43	autophagy related 5	Rattus norvegicus	72-76
30056017-9	2018	The effects of autophagy inhibition of 3-MA on the expressions of LC3B, Atg5, and Beclin-1 were investigated by real-time PCR and Western blotting, as well as the alpha-SMA, TGF-beta1, ColI, Col III, FN, MMP-2, MMP-13, TIMP-1 and TIMP-2.	3-methyladenine	39-43	beclin 1	Rattus norvegicus	82-90
30015901-12	2018	Upregulation of autophagy by AMPK activator 5-aminoimidazole-4-carboxamide1-beta-D-ribofuranoside decreased ROS and malondialdehyde generation, whereas inhibition of autophagy by 3-methyladenine and AMPK inhibitor compound C aggravated hIAPP-induced oxidative stress and toxicity in INS-1 cells.	3-methyladenine	179-194	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	29-33
30180452-11	2018	Autophagic inhibitor 3-MA and compound C aggravated the hIAPP-induced cell death and ROS generation in INS-1 cells (All P&lt;0.05).	3-methyladenine	21-25	islet amyloid polypeptide	Homo sapiens	56-61
30154458-8	2018	Co-injection of the pharmacological autophagy inhibitor 3-methyladenine prevented not only autophagy induction but also CASPASE-3 activation and calpain-dependent cleavage of SPECTRIN 24 h after the insult, thus providing a strong reduction of the long term brain injury (16 days after ibotenate injection) including lateral ventricle dilatation, decreases in cerebral tissue volume and in subcortical white matter thickness.	3-methyladenine	56-71	caspase 3	Rattus norvegicus	120-129
29856989-5	2018	Based on the observation that both downregulated expression of p-mTOR/m-TOR and upregulated ratio of LC3-II/beta-actin were induced by Abeta1-42 oligo, we then applied 3-MA, an inhibitor of autophagy, to test the role of autophagy in Abeta1-42 oligo induced Tight junction (TJ) proteins damage.	3-methyladenine	168-172	tortured	Mus musculus	66-69
29856989-5	2018	Based on the observation that both downregulated expression of p-mTOR/m-TOR and upregulated ratio of LC3-II/beta-actin were induced by Abeta1-42 oligo, we then applied 3-MA, an inhibitor of autophagy, to test the role of autophagy in Abeta1-42 oligo induced Tight junction (TJ) proteins damage.	3-methyladenine	168-172	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	101-112
29856989-6	2018	Results have shown that 3-MA partially reversed Abeta1-42 oligo induced downregulation of ZO-1, Occludin and Claudin-5, which was further determined by LC3 siRNA.	3-methyladenine	24-28	tight junction protein 1	Mus musculus	90-94
29856989-6	2018	Results have shown that 3-MA partially reversed Abeta1-42 oligo induced downregulation of ZO-1, Occludin and Claudin-5, which was further determined by LC3 siRNA.	3-methyladenine	24-28	occludin	Mus musculus	96-104
29856989-6	2018	Results have shown that 3-MA partially reversed Abeta1-42 oligo induced downregulation of ZO-1, Occludin and Claudin-5, which was further determined by LC3 siRNA.	3-methyladenine	24-28	claudin 5	Mus musculus	109-118
29856989-6	2018	Results have shown that 3-MA partially reversed Abeta1-42 oligo induced downregulation of ZO-1, Occludin and Claudin-5, which was further determined by LC3 siRNA.	3-methyladenine	24-28	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	152-155
29214369-5	2018	Surprisingly, GK, but not GB, promoted the clearance of A53T alpha-syn, which can be abolished by autophagy inhibitor 3-methyladenine, indicating that GK-induced autophagy intervened in the clearance of A53T alpha-syn.	3-methyladenine	118-133	synuclein alpha	Homo sapiens	61-70
30116320-9	2018	Inhibiting autophagy using 3-MA, resulted in a significant decrease in LC3-II, beclin-1 and LDH, as well as increase in the expression of BIP, CHOP, caspase 3, cleaved caspase 3 and Bax.	3-methyladenine	27-31	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	71-74
30116320-9	2018	Inhibiting autophagy using 3-MA, resulted in a significant decrease in LC3-II, beclin-1 and LDH, as well as increase in the expression of BIP, CHOP, caspase 3, cleaved caspase 3 and Bax.	3-methyladenine	27-31	beclin 1	Homo sapiens	79-95
30116320-9	2018	Inhibiting autophagy using 3-MA, resulted in a significant decrease in LC3-II, beclin-1 and LDH, as well as increase in the expression of BIP, CHOP, caspase 3, cleaved caspase 3 and Bax.	3-methyladenine	27-31	heat shock protein family A (Hsp70) member 5	Homo sapiens	138-141
30116320-9	2018	Inhibiting autophagy using 3-MA, resulted in a significant decrease in LC3-II, beclin-1 and LDH, as well as increase in the expression of BIP, CHOP, caspase 3, cleaved caspase 3 and Bax.	3-methyladenine	27-31	DNA damage inducible transcript 3	Homo sapiens	143-147
30116320-9	2018	Inhibiting autophagy using 3-MA, resulted in a significant decrease in LC3-II, beclin-1 and LDH, as well as increase in the expression of BIP, CHOP, caspase 3, cleaved caspase 3 and Bax.	3-methyladenine	27-31	caspase 3	Homo sapiens	149-158
30116320-9	2018	Inhibiting autophagy using 3-MA, resulted in a significant decrease in LC3-II, beclin-1 and LDH, as well as increase in the expression of BIP, CHOP, caspase 3, cleaved caspase 3 and Bax.	3-methyladenine	27-31	caspase 3	Homo sapiens	168-177
30116320-9	2018	Inhibiting autophagy using 3-MA, resulted in a significant decrease in LC3-II, beclin-1 and LDH, as well as increase in the expression of BIP, CHOP, caspase 3, cleaved caspase 3 and Bax.	3-methyladenine	27-31	BCL2 associated X, apoptosis regulator	Homo sapiens	182-185
29749471-9	2018	Furthermore, blockade of temozolomide (TMZ)-induced autophagy by 3-methyladenine (3-MA) resulted in enhanced activation of apoptotic markers, as well as tumor suppresor protein p53 (p53) expression in U87MG cells.	3-methyladenine	82-86	tumor protein p53	Homo sapiens	177-180
29749471-9	2018	Furthermore, blockade of temozolomide (TMZ)-induced autophagy by 3-methyladenine (3-MA) resulted in enhanced activation of apoptotic markers, as well as tumor suppresor protein p53 (p53) expression in U87MG cells.	3-methyladenine	82-86	tumor protein p53	Homo sapiens	182-185
30062060-7	2018	To delineate the role of autophagy during cell death, application of autophagy-inducer rapamycin enhanced, whereas autophagy inhibitor 3-MA attenuated, the alpha-MSH-induced apoptosis in melanoma cells.	3-methyladenine	135-139	proopiomelanocortin	Homo sapiens	156-165
29749472-9	2018	CD133 was localized to autophagosomes, and was suppressed by 3-MA or chloroquine (CQ) after iRFA treatment.	3-methyladenine	61-65	prominin 1	Homo sapiens	0-5
29730170-11	2018	Compared with rosiglitazone group, 3-MA administration, but not Compound C administration, significantly increased the levels of TNF-alpha, IL-1beta, SOD and MDA in hippocampus.	3-methyladenine	35-39	tumor necrosis factor	Rattus norvegicus	129-138
29730170-11	2018	Compared with rosiglitazone group, 3-MA administration, but not Compound C administration, significantly increased the levels of TNF-alpha, IL-1beta, SOD and MDA in hippocampus.	3-methyladenine	35-39	interleukin 1 beta	Rattus norvegicus	140-148
29915584-8	2018	In vitro analysis demonstrated that the blockade of autophagy with 3-methyladenine (3-MA) in Mycobacterium leprae-stimulated human primary monocytes increased the assembly of NLRP3 specks assembly, and it was associated with an increase of IL-1beta and IL-6 production.	3-methyladenine	67-82	NLR family pyrin domain containing 3	Homo sapiens	175-180
29915584-8	2018	In vitro analysis demonstrated that the blockade of autophagy with 3-methyladenine (3-MA) in Mycobacterium leprae-stimulated human primary monocytes increased the assembly of NLRP3 specks assembly, and it was associated with an increase of IL-1beta and IL-6 production.	3-methyladenine	67-82	interleukin 1 beta	Homo sapiens	240-248
29915584-8	2018	In vitro analysis demonstrated that the blockade of autophagy with 3-methyladenine (3-MA) in Mycobacterium leprae-stimulated human primary monocytes increased the assembly of NLRP3 specks assembly, and it was associated with an increase of IL-1beta and IL-6 production.	3-methyladenine	67-82	interleukin 6	Homo sapiens	253-257
29915584-8	2018	In vitro analysis demonstrated that the blockade of autophagy with 3-methyladenine (3-MA) in Mycobacterium leprae-stimulated human primary monocytes increased the assembly of NLRP3 specks assembly, and it was associated with an increase of IL-1beta and IL-6 production.	3-methyladenine	84-88	NLR family pyrin domain containing 3	Homo sapiens	175-180
29915584-8	2018	In vitro analysis demonstrated that the blockade of autophagy with 3-methyladenine (3-MA) in Mycobacterium leprae-stimulated human primary monocytes increased the assembly of NLRP3 specks assembly, and it was associated with an increase of IL-1beta and IL-6 production.	3-methyladenine	84-88	interleukin 1 beta	Homo sapiens	240-248
29915584-8	2018	In vitro analysis demonstrated that the blockade of autophagy with 3-methyladenine (3-MA) in Mycobacterium leprae-stimulated human primary monocytes increased the assembly of NLRP3 specks assembly, and it was associated with an increase of IL-1beta and IL-6 production.	3-methyladenine	84-88	interleukin 6	Homo sapiens	253-257
29551587-7	2018	The inhibition of autophagy by 3-methyladenine (3-MA) reversed the effects of CAN on IL-1alpha levels.	3-methyladenine	31-46	interleukin 1 alpha	Mus musculus	85-94
29551587-7	2018	The inhibition of autophagy by 3-methyladenine (3-MA) reversed the effects of CAN on IL-1alpha levels.	3-methyladenine	48-52	interleukin 1 alpha	Mus musculus	85-94
29775658-5	2018	Concurrently, HSYA and 3-MA also inhibited OGD/R-induced autophagy evidenced by the decreased number of autophagosomes and down-regulated levels of LC3 and Beclin-1 proteins and mRNAs.	3-methyladenine	23-27	annexin A3	Rattus norvegicus	148-151
29775658-5	2018	Concurrently, HSYA and 3-MA also inhibited OGD/R-induced autophagy evidenced by the decreased number of autophagosomes and down-regulated levels of LC3 and Beclin-1 proteins and mRNAs.	3-methyladenine	23-27	beclin 1	Rattus norvegicus	156-164
29492901-11	2018	CONCLUSIONS: From our results we conclude that DENSpm-induced apoptotic cell death is increased when autophagy is inhibited by 3-MA or Beclin-1 siRNA through PA depletion and PA catabolic activation in colon cancer cells, regardless p53 mutation status.	3-methyladenine	127-131	tumor protein p53	Homo sapiens	233-236
29858017-4	2018	We found that the silencing of miR-143 promoted the autophagy of c-kit+ CPCs in response to H2O2, and the protective effect of miR-143 inhibitor was abrogated by autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	182-197	microRNA 143	Mus musculus	31-38
29858017-4	2018	We found that the silencing of miR-143 promoted the autophagy of c-kit+ CPCs in response to H2O2, and the protective effect of miR-143 inhibitor was abrogated by autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	182-197	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	65-70
29858017-4	2018	We found that the silencing of miR-143 promoted the autophagy of c-kit+ CPCs in response to H2O2, and the protective effect of miR-143 inhibitor was abrogated by autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	182-197	microRNA 143	Mus musculus	127-134
29858017-4	2018	We found that the silencing of miR-143 promoted the autophagy of c-kit+ CPCs in response to H2O2, and the protective effect of miR-143 inhibitor was abrogated by autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	199-203	microRNA 143	Mus musculus	31-38
29858017-4	2018	We found that the silencing of miR-143 promoted the autophagy of c-kit+ CPCs in response to H2O2, and the protective effect of miR-143 inhibitor was abrogated by autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	199-203	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	65-70
29858017-4	2018	We found that the silencing of miR-143 promoted the autophagy of c-kit+ CPCs in response to H2O2, and the protective effect of miR-143 inhibitor was abrogated by autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	199-203	microRNA 143	Mus musculus	127-134
29532851-5	2018	The inhibition of autophagy following treatment with 3-methyladenine significantly reversed the effect of si-miRNA-30e on apoptosis, Bax, caspase-3, iNOS and oxidative stress in H9C2 cells.	3-methyladenine	53-68	BCL2 associated X, apoptosis regulator	Rattus norvegicus	133-136
29532851-5	2018	The inhibition of autophagy following treatment with 3-methyladenine significantly reversed the effect of si-miRNA-30e on apoptosis, Bax, caspase-3, iNOS and oxidative stress in H9C2 cells.	3-methyladenine	53-68	caspase 3	Rattus norvegicus	138-147
29532851-5	2018	The inhibition of autophagy following treatment with 3-methyladenine significantly reversed the effect of si-miRNA-30e on apoptosis, Bax, caspase-3, iNOS and oxidative stress in H9C2 cells.	3-methyladenine	53-68	nitric oxide synthase 2	Rattus norvegicus	149-153
29086202-9	2018	Inhibition of autophagy by 3-methyladenine (3-MA) elevated TCF21 expression and increased cell apoptosis.	3-methyladenine	27-42	transcription factor 21	Homo sapiens	59-64
29086202-9	2018	Inhibition of autophagy by 3-methyladenine (3-MA) elevated TCF21 expression and increased cell apoptosis.	3-methyladenine	44-48	transcription factor 21	Homo sapiens	59-64
30693689-7	2018	When curcumin and 3-MA were given concurrently, the number of surviving dopamine neurons, protein expression of TFEB, LAMP2A and LC3-II increased (P<0.05 or P<0.01), and both protein expression and mRNA expression of alpha-Syn decreased (P<0.05 or P<0.01) compared with MPTP model group; but the number of surviving dopamine neurons and protein expression of LAMP2A and LC3-II decreased compared with curcumin group (all P<0.05).	3-methyladenine	18-22	transcription factor EB	Homo sapiens	112-116
30693689-7	2018	When curcumin and 3-MA were given concurrently, the number of surviving dopamine neurons, protein expression of TFEB, LAMP2A and LC3-II increased (P<0.05 or P<0.01), and both protein expression and mRNA expression of alpha-Syn decreased (P<0.05 or P<0.01) compared with MPTP model group; but the number of surviving dopamine neurons and protein expression of LAMP2A and LC3-II decreased compared with curcumin group (all P<0.05).	3-methyladenine	18-22	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	129-132
30693689-7	2018	When curcumin and 3-MA were given concurrently, the number of surviving dopamine neurons, protein expression of TFEB, LAMP2A and LC3-II increased (P<0.05 or P<0.01), and both protein expression and mRNA expression of alpha-Syn decreased (P<0.05 or P<0.01) compared with MPTP model group; but the number of surviving dopamine neurons and protein expression of LAMP2A and LC3-II decreased compared with curcumin group (all P<0.05).	3-methyladenine	18-22	synuclein alpha	Homo sapiens	217-226
30693689-7	2018	When curcumin and 3-MA were given concurrently, the number of surviving dopamine neurons, protein expression of TFEB, LAMP2A and LC3-II increased (P<0.05 or P<0.01), and both protein expression and mRNA expression of alpha-Syn decreased (P<0.05 or P<0.01) compared with MPTP model group; but the number of surviving dopamine neurons and protein expression of LAMP2A and LC3-II decreased compared with curcumin group (all P<0.05).	3-methyladenine	18-22	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	370-373
29518394-5	2018	Inhibition of autophagy by 3-methyladenine (3-MA) abrogated the enhancing effects of ISG15 on cholesterol efflux.	3-methyladenine	27-42	ISG15 ubiquitin like modifier	Homo sapiens	85-90
29518394-5	2018	Inhibition of autophagy by 3-methyladenine (3-MA) abrogated the enhancing effects of ISG15 on cholesterol efflux.	3-methyladenine	44-48	ISG15 ubiquitin like modifier	Homo sapiens	85-90
29476905-10	2018	Furthermore, the autophagy inhibitor 3-MA abolished the protective effects of TAX1BP1 in vivo.	3-methyladenine	37-41	Tax1 (human T cell leukemia virus type I) binding protein 1	Mus musculus	78-85
29501733-12	2018	(5) The autophagy inhibitor 3-MA inhibited CsA-induced TNF-alpha and IFN-alpha up-regulation and fibrosis.	3-methyladenine	28-32	tumor necrosis factor	Homo sapiens	55-64
29501733-12	2018	(5) The autophagy inhibitor 3-MA inhibited CsA-induced TNF-alpha and IFN-alpha up-regulation and fibrosis.	3-methyladenine	28-32	interferon alpha 1	Homo sapiens	69-78
29577663-10	2018	When pretreated with 3-MA, LC3B II formation and the cytotoxicity declined.	3-methyladenine	21-25	microtubule associated protein 1 light chain 3 beta	Homo sapiens	27-31
30320187-6	2018	Furthermore, inhibition autophagy with 3-MA can attenuate the suppressive effect of BRF1 on LPS-mediated inflammation.	3-methyladenine	39-43	BRF1 RNA polymerase III transcription initiation factor subunit	Homo sapiens	84-88
29677174-10	2018	RESULTS In the 3-MA Group, the level of histological analysis, lung wet/dry ratio, total protein of BAL (bronchoalveolar lavage fluid) and TNF-a level were higher than the L group (p&lt;0.05), the level of autophagy was lower than the L group (p&lt;0.05), and the level of CXCL16 was higher than the L group (p&lt;0.05).	3-methyladenine	15-19	tumor necrosis factor	Mus musculus	139-144
29677174-10	2018	RESULTS In the 3-MA Group, the level of histological analysis, lung wet/dry ratio, total protein of BAL (bronchoalveolar lavage fluid) and TNF-a level were higher than the L group (p&lt;0.05), the level of autophagy was lower than the L group (p&lt;0.05), and the level of CXCL16 was higher than the L group (p&lt;0.05).	3-methyladenine	15-19	chemokine (C-X-C motif) ligand 16	Mus musculus	273-279
29719536-3	2018	In this report, we evaluated if phosphatidyl-inositol-3 kinase (PI3K) pharmacological inhibitors LY294200 and 3-methyladenine (3-MA) can modulate the innate immune response to PGN in the central nervous system.	3-methyladenine	110-125	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	32-62
29719536-3	2018	In this report, we evaluated if phosphatidyl-inositol-3 kinase (PI3K) pharmacological inhibitors LY294200 and 3-methyladenine (3-MA) can modulate the innate immune response to PGN in the central nervous system.	3-methyladenine	127-131	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	32-62
29656300-10	2018	N-acetyl-L-cysteine (NAC) partially attenuated SIX1 siRNA-induced ROS level increases, and autophagy inhibitor 3-MA notably enhanced SIX1 siRNA-induced cell apoptosis.	3-methyladenine	111-115	SIX homeobox 1	Homo sapiens	133-137
29896416-8	2018	After addition of the autophagy inhibitor 3-MA, the protective effect of SIRT3 diminished: the cell viability decreased, while the apoptosis rate increased; alpha-synuclein accumulation enhanced; ROS production increased; antioxidants levels, including SOD and GSH, decreased; and MMP collapsed.	3-methyladenine	42-46	sirtuin 3	Homo sapiens	73-78
29896416-8	2018	After addition of the autophagy inhibitor 3-MA, the protective effect of SIRT3 diminished: the cell viability decreased, while the apoptosis rate increased; alpha-synuclein accumulation enhanced; ROS production increased; antioxidants levels, including SOD and GSH, decreased; and MMP collapsed.	3-methyladenine	42-46	synuclein alpha	Homo sapiens	157-172
29421576-15	2018	MiR-93-5p could target regulate PTEN negatively, and exhibit the similar effect of 3-MA on the survival of RGCs.	3-methyladenine	83-87	microRNA 935	Rattus norvegicus	0-9
29327381-14	2018	3-Methyladenine further increased H2 O2 -induced p-ERK expression.	3-methyladenine	0-15	Eph receptor B1	Rattus norvegicus	51-54
29545877-10	2018	In addition, 3-MA and DEX reduced the protein expression levels of LC3-I, LC3-II, ATG5, Rab7 and LAMP1.	3-methyladenine	13-17	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	67-70
29545877-10	2018	In addition, 3-MA and DEX reduced the protein expression levels of LC3-I, LC3-II, ATG5, Rab7 and LAMP1.	3-methyladenine	13-17	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	74-77
29545877-10	2018	In addition, 3-MA and DEX reduced the protein expression levels of LC3-I, LC3-II, ATG5, Rab7 and LAMP1.	3-methyladenine	13-17	autophagy related 5	Mus musculus	82-86
29545877-10	2018	In addition, 3-MA and DEX reduced the protein expression levels of LC3-I, LC3-II, ATG5, Rab7 and LAMP1.	3-methyladenine	13-17	RAB7, member RAS oncogene family	Mus musculus	88-92
29545877-10	2018	In addition, 3-MA and DEX reduced the protein expression levels of LC3-I, LC3-II, ATG5, Rab7 and LAMP1.	3-methyladenine	13-17	lysosomal-associated membrane protein 1	Mus musculus	97-102
29545877-11	2018	Also, RT-qPCR results revealed that NF-kappaB and TLR4 mRNA expression levels were clearly decreased in the 3-MA and DEX groups compared with the model group.	3-methyladenine	108-112	toll-like receptor 4	Mus musculus	50-54
29545877-12	2018	In conclusion, LPS-induced ALI was effectively reversed by treatment with 3-MA and DEX through the reduction of inflammation and autophagy and inhibition of the TLR4-NF-kappaB pathway.	3-methyladenine	74-78	toll-like receptor 4	Mus musculus	161-165
29278657-8	2018	JAK2/STAT3 pathway was suppressed by PEITC, and further inhibited by 3-MA and CQ or Beclin-1 knock down, as a result of decreased expression of p-JAK2 and p-STAT3.	3-methyladenine	69-73	Janus kinase 2	Homo sapiens	0-4
29278657-8	2018	JAK2/STAT3 pathway was suppressed by PEITC, and further inhibited by 3-MA and CQ or Beclin-1 knock down, as a result of decreased expression of p-JAK2 and p-STAT3.	3-methyladenine	69-73	signal transducer and activator of transcription 3	Homo sapiens	5-10
29278657-8	2018	JAK2/STAT3 pathway was suppressed by PEITC, and further inhibited by 3-MA and CQ or Beclin-1 knock down, as a result of decreased expression of p-JAK2 and p-STAT3.	3-methyladenine	69-73	Janus kinase 2	Homo sapiens	146-150
29278657-8	2018	JAK2/STAT3 pathway was suppressed by PEITC, and further inhibited by 3-MA and CQ or Beclin-1 knock down, as a result of decreased expression of p-JAK2 and p-STAT3.	3-methyladenine	69-73	signal transducer and activator of transcription 3	Homo sapiens	157-162
29538296-10	2018	Moreover, knockdown of CHOP or ATG5 and treatment with 4-PBA or 3-MA abolished the SH-mediated inhibition of mesenchymal markers (vimentin, Snail and Slug) expression and cell invasion, respectively.	3-methyladenine	64-68	vimentin	Homo sapiens	130-138
29538296-10	2018	Moreover, knockdown of CHOP or ATG5 and treatment with 4-PBA or 3-MA abolished the SH-mediated inhibition of mesenchymal markers (vimentin, Snail and Slug) expression and cell invasion, respectively.	3-methyladenine	64-68	snail family transcriptional repressor 1	Homo sapiens	140-145
29538296-10	2018	Moreover, knockdown of CHOP or ATG5 and treatment with 4-PBA or 3-MA abolished the SH-mediated inhibition of mesenchymal markers (vimentin, Snail and Slug) expression and cell invasion, respectively.	3-methyladenine	64-68	snail family transcriptional repressor 2	Homo sapiens	150-154
29476739-5	2018	Furthermore, suppression of autophagy with chloroquine (CQ) or 3-MA could significantly attenuate the enhanced osteoclastogenesis by a low level of IL-17A.	3-methyladenine	63-67	interleukin 17A	Homo sapiens	148-154
29193611-8	2018	However, 3-MA pretreatment inhibited autophagy resulting in increase of alpha-Syn oligomers, and compensatorily activated PERK signaling pathway.	3-methyladenine	9-13	synuclein, alpha	Mus musculus	72-81
29061481-6	2018	Inhibiting autophagy with chloroquine (CQ) and 3-Methyladenine (3-MA) significantly augmented palmitate-induced PBMCs apoptotic death as demonstrated by increased cleaved PARP level and increased the percentage of apoptotic (YO-PRO-1 positive and PI negative) cells.	3-methyladenine	47-62	collagen type XI alpha 2 chain	Homo sapiens	171-175
29061481-6	2018	Inhibiting autophagy with chloroquine (CQ) and 3-Methyladenine (3-MA) significantly augmented palmitate-induced PBMCs apoptotic death as demonstrated by increased cleaved PARP level and increased the percentage of apoptotic (YO-PRO-1 positive and PI negative) cells.	3-methyladenine	47-62	lamin A/C	Homo sapiens	228-233
29061481-6	2018	Inhibiting autophagy with chloroquine (CQ) and 3-Methyladenine (3-MA) significantly augmented palmitate-induced PBMCs apoptotic death as demonstrated by increased cleaved PARP level and increased the percentage of apoptotic (YO-PRO-1 positive and PI negative) cells.	3-methyladenine	64-68	collagen type XI alpha 2 chain	Homo sapiens	171-175
29061481-6	2018	Inhibiting autophagy with chloroquine (CQ) and 3-Methyladenine (3-MA) significantly augmented palmitate-induced PBMCs apoptotic death as demonstrated by increased cleaved PARP level and increased the percentage of apoptotic (YO-PRO-1 positive and PI negative) cells.	3-methyladenine	64-68	lamin A/C	Homo sapiens	228-233
29305119-9	2018	Moreover, autophagy inhibitor 3-MA and NLRP3 activator ATP blocked the effect of Weicao on autophagy induction and NLRP3 inflammasome degradation.	3-methyladenine	30-34	NLR family, pyrin domain containing 3	Rattus norvegicus	115-120
29737742-15	2018	After using 3-MA to inhibit autophagy, the expression of LC3-II was significantly decreased (P&lt;0.05), and the expression of Caspase-3 was decreased along with LC3-II, but the decrease of Caspase-3 expression was only significant in OPC and MIX group (P&lt;0.05).	3-methyladenine	12-16	caspase 3	Homo sapiens	127-136
29737742-15	2018	After using 3-MA to inhibit autophagy, the expression of LC3-II was significantly decreased (P&lt;0.05), and the expression of Caspase-3 was decreased along with LC3-II, but the decrease of Caspase-3 expression was only significant in OPC and MIX group (P&lt;0.05).	3-methyladenine	12-16	caspase 3	Homo sapiens	190-199
29328481-6	2018	Pretreatment with the autophagy inhibitor 3-methyladenine promoted TTF1-NP-induced apoptosis.	3-methyladenine	42-57	transcription termination factor 1	Homo sapiens	67-71
29515581-5	2018	Our findings indicated that inhibition of autophagy with 3-methyladenine and Wortmannin markedly reduced IL-1beta secretion induced by LPS + ATP, as did the disruption of the autophagic flux with Bafilomycin A1 and E64d.	3-methyladenine	57-72	interleukin 1 beta	Homo sapiens	105-113
29636842-6	2018	Furthermore, the expression levels of caspase-1, IL-1beta, and IL-18 in BMDMs were elevated after treatment with mitophagy inhibitor 3-MA.	3-methyladenine	133-137	caspase 1	Mus musculus	38-47
29636842-6	2018	Furthermore, the expression levels of caspase-1, IL-1beta, and IL-18 in BMDMs were elevated after treatment with mitophagy inhibitor 3-MA.	3-methyladenine	133-137	interleukin 1 beta	Mus musculus	49-57
29636842-6	2018	Furthermore, the expression levels of caspase-1, IL-1beta, and IL-18 in BMDMs were elevated after treatment with mitophagy inhibitor 3-MA.	3-methyladenine	133-137	interleukin 18	Mus musculus	63-68
29324976-5	2018	3-Methyl-adennine (3-MA), the most widely used autophagy inhibitor, strongly up-regulated the expression of cleaved caspase-3, and blocked the anti-apoptosis function of Rg1 in macrophages.	3-methyladenine	19-23	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	170-173
29210183-7	2018	In vitro, young serum could protect old hepatocytes from senescence, and the antisenescence effect of young serum was abrogated by 3-methyladenine, wortmannin, or small interfering RNA to autophagy-related protein 7.	3-methyladenine	131-146	autophagy related 7	Rattus norvegicus	188-215
29225132-6	2018	Furthermore, apoptosis played a dominant role in Rh4-induced cell death, as the pan-caspase inhibitor Z-VAD-FMK blocked cell death to a greater extent than the autophagy inhibitor 3-methyladenine.	3-methyladenine	180-195	Rh blood group D antigen	Homo sapiens	49-52
29307663-7	2018	Surprisingly, formation of multicellular aggregates and pro-inflammatory cytokine production were both attenuated by either down-regulation of autophagy with inhibitors, such as 3-methyladenine (3MA) or chloroquine (CQ), or repression of endocytosis with siRNA targeting Endo180.	3-methyladenine	178-193	mannose receptor C type 2	Homo sapiens	271-278
28817179-7	2018	Autophagy inhibition by 3 methyladenine (3MA) or RNA interference of LC3B resulted in increased levels of cleaved PARP and caspase-3, and the release of cytochrome c from mitochondria into cytosol in the CoCl2 -treated HDPCs.	3-methyladenine	24-39	collagen type XI alpha 2 chain	Homo sapiens	114-118
28817179-7	2018	Autophagy inhibition by 3 methyladenine (3MA) or RNA interference of LC3B resulted in increased levels of cleaved PARP and caspase-3, and the release of cytochrome c from mitochondria into cytosol in the CoCl2 -treated HDPCs.	3-methyladenine	24-39	caspase 3	Homo sapiens	123-132
28817179-7	2018	Autophagy inhibition by 3 methyladenine (3MA) or RNA interference of LC3B resulted in increased levels of cleaved PARP and caspase-3, and the release of cytochrome c from mitochondria into cytosol in the CoCl2 -treated HDPCs.	3-methyladenine	24-39	cytochrome c, somatic	Homo sapiens	153-165
28817179-7	2018	Autophagy inhibition by 3 methyladenine (3MA) or RNA interference of LC3B resulted in increased levels of cleaved PARP and caspase-3, and the release of cytochrome c from mitochondria into cytosol in the CoCl2 -treated HDPCs.	3-methyladenine	41-44	collagen type XI alpha 2 chain	Homo sapiens	114-118
28817179-7	2018	Autophagy inhibition by 3 methyladenine (3MA) or RNA interference of LC3B resulted in increased levels of cleaved PARP and caspase-3, and the release of cytochrome c from mitochondria into cytosol in the CoCl2 -treated HDPCs.	3-methyladenine	41-44	caspase 3	Homo sapiens	123-132
28817179-7	2018	Autophagy inhibition by 3 methyladenine (3MA) or RNA interference of LC3B resulted in increased levels of cleaved PARP and caspase-3, and the release of cytochrome c from mitochondria into cytosol in the CoCl2 -treated HDPCs.	3-methyladenine	41-44	cytochrome c, somatic	Homo sapiens	153-165
29207188-12	2018	In contrast, GA-induced LC3 conversion was significantly inhibited by 3 methlyadenine (3MA), an inhibitor of PI3K-regulated autophagy.	3-methyladenine	87-90	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	24-27
29352194-8	2018	3-methyladenine (3-MA) and chloroquine (CQ)-mediated inhibition of autophagy partially reversed the anti-senescent and anti-apoptotic effects of sirt6, which regulated the expression of degeneration-associated proteins.	3-methyladenine	0-15	sirtuin 6	Homo sapiens	145-150
29352194-8	2018	3-methyladenine (3-MA) and chloroquine (CQ)-mediated inhibition of autophagy partially reversed the anti-senescent and anti-apoptotic effects of sirt6, which regulated the expression of degeneration-associated proteins.	3-methyladenine	17-21	sirtuin 6	Homo sapiens	145-150
29379301-5	2018	On the other hand, inhibition of autophagy by 3-methyl adenine (3-MA) could rescue rapamycin-directed downregulation of GPC3 and wnt/beta-catenin target genes and augment the proliferation of HepG2 cells.	3-methyladenine	46-62	glypican 3	Homo sapiens	120-124
29379301-5	2018	On the other hand, inhibition of autophagy by 3-methyl adenine (3-MA) could rescue rapamycin-directed downregulation of GPC3 and wnt/beta-catenin target genes and augment the proliferation of HepG2 cells.	3-methyladenine	46-62	catenin beta 1	Homo sapiens	133-145
29379301-5	2018	On the other hand, inhibition of autophagy by 3-methyl adenine (3-MA) could rescue rapamycin-directed downregulation of GPC3 and wnt/beta-catenin target genes and augment the proliferation of HepG2 cells.	3-methyladenine	64-68	glypican 3	Homo sapiens	120-124
29379301-5	2018	On the other hand, inhibition of autophagy by 3-methyl adenine (3-MA) could rescue rapamycin-directed downregulation of GPC3 and wnt/beta-catenin target genes and augment the proliferation of HepG2 cells.	3-methyladenine	64-68	catenin beta 1	Homo sapiens	133-145
29052054-8	2018	Finally, immunofluorescence staining demonstrated that TLR7 endosome marker M6PR levels were clearly reduced in EV71- and CA16-infected cells, while they were markedly elevated in infected cells treated with 3-MA.	3-methyladenine	208-212	toll like receptor 7	Homo sapiens	55-59
29962266-7	2018	FCGR3- NK with a phenotype of PTGS2/COX2high IFNGlow PRF1low GZMBlow induced by hck knockout (hck-/-) or 3-methyladenine (3-MA, an autophagy inhibitor)-stimulated ESCs accelerates ESC"s growth both in vitro and in vivo.	3-methyladenine	105-120	Fc gamma receptor IIIa	Homo sapiens	0-5
29962266-7	2018	FCGR3- NK with a phenotype of PTGS2/COX2high IFNGlow PRF1low GZMBlow induced by hck knockout (hck-/-) or 3-methyladenine (3-MA, an autophagy inhibitor)-stimulated ESCs accelerates ESC"s growth both in vitro and in vivo.	3-methyladenine	105-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-40
29962266-7	2018	FCGR3- NK with a phenotype of PTGS2/COX2high IFNGlow PRF1low GZMBlow induced by hck knockout (hck-/-) or 3-methyladenine (3-MA, an autophagy inhibitor)-stimulated ESCs accelerates ESC"s growth both in vitro and in vivo.	3-methyladenine	105-120	perforin 1	Homo sapiens	53-57
29962266-7	2018	FCGR3- NK with a phenotype of PTGS2/COX2high IFNGlow PRF1low GZMBlow induced by hck knockout (hck-/-) or 3-methyladenine (3-MA, an autophagy inhibitor)-stimulated ESCs accelerates ESC"s growth both in vitro and in vivo.	3-methyladenine	122-126	Fc gamma receptor IIIa	Homo sapiens	0-5
29962266-7	2018	FCGR3- NK with a phenotype of PTGS2/COX2high IFNGlow PRF1low GZMBlow induced by hck knockout (hck-/-) or 3-methyladenine (3-MA, an autophagy inhibitor)-stimulated ESCs accelerates ESC"s growth both in vitro and in vivo.	3-methyladenine	122-126	perforin 1	Homo sapiens	53-57
29969945-7	2018	Additionally, we found that knockdown of early autophagy components, ATG5 and ATG7, and treatment with pharmacological autophagy inhibitors, wortmannin and 3-methyladenine, abolished the unconventional secretion of CFTR that had been stimulated by ER stress and an ER-to-Golgi blockade.	3-methyladenine	156-171	CF transmembrane conductance regulator	Homo sapiens	215-219
29191652-7	2018	Even when 3-Methyladenine, an inhibitor of autophagy, was added, the increase of EPO mRNA expression due to hypoxia was not affected.	3-methyladenine	10-25	erythropoietin	Homo sapiens	81-84
29669987-8	2018	Further mechanistic insights demonstrated that chloroform up-regulated pro-inflammatory cytokine, IL-1beta, in the livers and blood, which was suppressed by 3-MA.	3-methyladenine	157-161	interleukin 1 beta	Mus musculus	98-106
29056525-12	2018	Pretreatment with RAP increased the level of LC3-II/LC3-I, and pretreatment with 3-MA increased the level of P62 in KD-fed rats.	3-methyladenine	81-85	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	109-112
29843152-11	2018	Furthermore, the inhibition of autophagy by 3-MA exacerbated apoptosis through ROS generation and JNK phosphorylation.	3-methyladenine	44-48	mitogen-activated protein kinase 8	Mus musculus	98-101
29138833-11	2018	Finally, miR-16 mimics inhibited TGF-beta1-induced EMT, and this effect was attenuated by autophagy inhibitor 3-MA.	3-methyladenine	110-114	glycerophosphodiester phosphodiesterase 1	Homo sapiens	9-15
29138833-11	2018	Finally, miR-16 mimics inhibited TGF-beta1-induced EMT, and this effect was attenuated by autophagy inhibitor 3-MA.	3-methyladenine	110-114	transforming growth factor beta 1	Homo sapiens	33-42
29259166-10	2017	Inhibition of autophagy by 3-MA suppressed autophagosome formation, reduced the apoptotic activation (cleaved caspase-3 and Bcl2) and the appearance of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive neurons, underlining that apoptosis and autophagy pathways are intricately intertwined.	3-methyladenine	27-31	caspase 3	Mus musculus	110-119
29259166-10	2017	Inhibition of autophagy by 3-MA suppressed autophagosome formation, reduced the apoptotic activation (cleaved caspase-3 and Bcl2) and the appearance of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive neurons, underlining that apoptosis and autophagy pathways are intricately intertwined.	3-methyladenine	27-31	B cell leukemia/lymphoma 2	Mus musculus	124-128
29311781-10	2017	Furthermore, the beneficial effects of netrin-1 were suppressed by PI3K inhibitors 3-Methyladenine and LY294002.	3-methyladenine	83-98	netrin 1	Rattus norvegicus	39-47
29061302-11	2017	Furthermore, macrophages tend to switch to the M1 phenotype, expressing higher iNOS and TNF-alpha when impair mitophagy by 3-MA.	3-methyladenine	123-127	nitric oxide synthase 2	Rattus norvegicus	79-83
29061302-11	2017	Furthermore, macrophages tend to switch to the M1 phenotype, expressing higher iNOS and TNF-alpha when impair mitophagy by 3-MA.	3-methyladenine	123-127	tumor necrosis factor	Rattus norvegicus	88-97
29344024-8	2017	3-Methyladenine, an autophagy inhibitor, inhibited apoptosis significantly in FITC-annexin V staining, and the inhibition of Bax, cytochrome c, and c-caspase-3 was shown by Western blotting.	3-methyladenine	0-15	BCL2 associated X, apoptosis regulator	Homo sapiens	125-128
29344024-8	2017	3-Methyladenine, an autophagy inhibitor, inhibited apoptosis significantly in FITC-annexin V staining, and the inhibition of Bax, cytochrome c, and c-caspase-3 was shown by Western blotting.	3-methyladenine	0-15	cytochrome c, somatic	Homo sapiens	130-142
29243791-10	2017	3-MA inhibited the ATG5-induced autophagy and improved the Ang II-induced myocardial hypertrophy, while the overexpression of ATG5 enhanced the myocardial autophagy and the expression of hypertrophic genes.	3-methyladenine	0-4	autophagy related 5	Rattus norvegicus	19-23
29243791-10	2017	3-MA inhibited the ATG5-induced autophagy and improved the Ang II-induced myocardial hypertrophy, while the overexpression of ATG5 enhanced the myocardial autophagy and the expression of hypertrophic genes.	3-methyladenine	0-4	angiotensinogen	Rattus norvegicus	59-65
28962872-6	2017	Caspase-mediated apoptosis by genipin and everolimus is further potentiated by the autophagy inhibitor 3-methyladenine revealing a protective role for Beclin1-mediated autophagy induced by the treatment.	3-methyladenine	103-118	beclin 1, autophagy related	Mus musculus	151-158
29096331-3	2017	Autophagy inhibitors 3-methyladenine and bafilomycin block the effect of NS targeting on differentiation, indicating a new functional link between NS and autophagy as an important regulator of differentiation in NB4 cells.	3-methyladenine	21-36	G protein nucleolar 3	Homo sapiens	73-75
29096331-3	2017	Autophagy inhibitors 3-methyladenine and bafilomycin block the effect of NS targeting on differentiation, indicating a new functional link between NS and autophagy as an important regulator of differentiation in NB4 cells.	3-methyladenine	21-36	G protein nucleolar 3	Homo sapiens	147-149
29039543-6	2017	Autophagy inhibition by 3-MA and Atg-5 siRNA could reverse the cell death effect mediated by TNF-alpha and ox-LDL co-treatment on chondrocytes.	3-methyladenine	24-28	tumor necrosis factor	Homo sapiens	93-102
27832521-6	2017	Blockade of autophagy flux with autophagy inhibitor 3-methyladenine or bafilomycin A1 resulted in further phosphorylation of p38alpha, polyubiquitinated protein aggregation, and greater apoptotic cell death.	3-methyladenine	52-67	mitogen-activated protein kinase 14	Homo sapiens	125-133
28944925-9	2017	Furthermore, the expression levels of LC3-II and Atg7 in HK-2 cells were significantly upregulated by iohexol administration; however, LC3-II and Atg7 expression was decreased by 3-MA treatment.	3-methyladenine	179-183	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	38-41
28944925-9	2017	Furthermore, the expression levels of LC3-II and Atg7 in HK-2 cells were significantly upregulated by iohexol administration; however, LC3-II and Atg7 expression was decreased by 3-MA treatment.	3-methyladenine	179-183	autophagy related 7	Homo sapiens	49-53
28944925-9	2017	Furthermore, the expression levels of LC3-II and Atg7 in HK-2 cells were significantly upregulated by iohexol administration; however, LC3-II and Atg7 expression was decreased by 3-MA treatment.	3-methyladenine	179-183	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	135-138
28944925-9	2017	Furthermore, the expression levels of LC3-II and Atg7 in HK-2 cells were significantly upregulated by iohexol administration; however, LC3-II and Atg7 expression was decreased by 3-MA treatment.	3-methyladenine	179-183	autophagy related 7	Homo sapiens	146-150
29382424-5	2017	The apoptotic protease caspase-3 and substrate PARP were obviously degraded, which could be enhanced by 3-MA but inhibited by CQ.	3-methyladenine	104-108	caspase 3	Homo sapiens	23-32
29382424-5	2017	The apoptotic protease caspase-3 and substrate PARP were obviously degraded, which could be enhanced by 3-MA but inhibited by CQ.	3-methyladenine	104-108	poly(ADP-ribose) polymerase 1	Homo sapiens	47-51
29296191-0	2017	3-Methyladenine ameliorates liver fibrosis through autophagy regulated by the NF-kappaB signaling pathways on hepatic stellate cell.	3-methyladenine	0-15	nuclear factor kappa B subunit 1	Homo sapiens	78-87
29296191-6	2017	Our studies proposed that 3-MA attenuates liver fibrosis induced by carbon tetrachloride (CCl4), and inhibit the expression of autophagy markers and transcriptional regulator NF-kappaB of hepatic stellate cell in vivo.	3-methyladenine	26-30	C-C motif chemokine ligand 4	Homo sapiens	90-94
29296191-6	2017	Our studies proposed that 3-MA attenuates liver fibrosis induced by carbon tetrachloride (CCl4), and inhibit the expression of autophagy markers and transcriptional regulator NF-kappaB of hepatic stellate cell in vivo.	3-methyladenine	26-30	nuclear factor kappa B subunit 1	Homo sapiens	175-184
29296191-8	2017	Conclusively, 3-MA ameliorates liver fibrosis through inhibition of autophagy regulated by the NF-kappaB signaling pathways on hepatic stellate cell.	3-methyladenine	14-18	nuclear factor kappa B subunit 1	Homo sapiens	95-104
28990778-8	2017	Compared with the BaP group, the autophagy inhibitor 3-MA significantly (p &lt; 0.01) inhibited the release of LDH by 70.53% +- 0.46 and NO by 50.36% +- 0.80, the increase of electrical conductivity by 12.08% +- 0.55, and the expressions of pyroptotic marker proteins (Caspase-1, Cox-2, IL-1beta, IL-18).	3-methyladenine	53-57	caspase 1	Homo sapiens	269-278
28990778-8	2017	Compared with the BaP group, the autophagy inhibitor 3-MA significantly (p &lt; 0.01) inhibited the release of LDH by 70.53% +- 0.46 and NO by 50.36% +- 0.80, the increase of electrical conductivity by 12.08% +- 0.55, and the expressions of pyroptotic marker proteins (Caspase-1, Cox-2, IL-1beta, IL-18).	3-methyladenine	53-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	280-285
28990778-8	2017	Compared with the BaP group, the autophagy inhibitor 3-MA significantly (p &lt; 0.01) inhibited the release of LDH by 70.53% +- 0.46 and NO by 50.36% +- 0.80, the increase of electrical conductivity by 12.08% +- 0.55, and the expressions of pyroptotic marker proteins (Caspase-1, Cox-2, IL-1beta, IL-18).	3-methyladenine	53-57	interleukin 1 beta	Homo sapiens	287-295
28990778-8	2017	Compared with the BaP group, the autophagy inhibitor 3-MA significantly (p &lt; 0.01) inhibited the release of LDH by 70.53% +- 0.46 and NO by 50.36% +- 0.80, the increase of electrical conductivity by 12.08% +- 0.55, and the expressions of pyroptotic marker proteins (Caspase-1, Cox-2, IL-1beta, IL-18).	3-methyladenine	53-57	interleukin 18	Homo sapiens	297-302
28882875-12	2017	In addition, by using a specific inhibitor 3-methyladenine, VPS34 was found to operate through a similar NOX-dependent mechanism to promote human platelet activation.	3-methyladenine	43-58	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	60-65
27936516-11	2017	Meanwhile, the degradation of Hsp27 was suppressed and neuronal damage was reduced when blocking autophagy with 3-Methyladenine, whereas activating autophagy with rapamycin showed an opposite tendency.	3-methyladenine	112-127	heat shock protein family B (small) member 1	Rattus norvegicus	30-35
28390176-7	2017	The Cucurbitacin B-mediated mitigated cardiac hypertrophy was attributable to the increasing level of autophagy, which was associated with the blockade of Akt/mTOR/FoxO3a signal pathway, validated by SC79, MK2206, and 3-MA, the Akt agonist, inhibitor and autophagy inhibitor in vitro.	3-methyladenine	218-222	thymoma viral proto-oncogene 1	Mus musculus	155-158
28834690-6	2017	More importantly, inhibition of autophagy by 3-MA relieved Malat1-induced cell proliferation.	3-methyladenine	45-49	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	59-65
29039784-5	2017	Furthermore, the findings also demonstrated that 3-MA inhibited the impact of AF/AD on autophagy, Atg5-Atg12 protein complex, Atg7, Atg10, Beclin-1, LC3 I, LC3 II, and DeltaPsim, and promoted the influence of AF/AD on apoptosis and p-P38MAPK in Bel-7402 cells.	3-methyladenine	49-53	autophagy related 5	Homo sapiens	98-102
29039784-5	2017	Furthermore, the findings also demonstrated that 3-MA inhibited the impact of AF/AD on autophagy, Atg5-Atg12 protein complex, Atg7, Atg10, Beclin-1, LC3 I, LC3 II, and DeltaPsim, and promoted the influence of AF/AD on apoptosis and p-P38MAPK in Bel-7402 cells.	3-methyladenine	49-53	autophagy related 12	Homo sapiens	103-108
29039784-5	2017	Furthermore, the findings also demonstrated that 3-MA inhibited the impact of AF/AD on autophagy, Atg5-Atg12 protein complex, Atg7, Atg10, Beclin-1, LC3 I, LC3 II, and DeltaPsim, and promoted the influence of AF/AD on apoptosis and p-P38MAPK in Bel-7402 cells.	3-methyladenine	49-53	autophagy related 7	Homo sapiens	126-130
29039784-5	2017	Furthermore, the findings also demonstrated that 3-MA inhibited the impact of AF/AD on autophagy, Atg5-Atg12 protein complex, Atg7, Atg10, Beclin-1, LC3 I, LC3 II, and DeltaPsim, and promoted the influence of AF/AD on apoptosis and p-P38MAPK in Bel-7402 cells.	3-methyladenine	49-53	autophagy related 10	Homo sapiens	132-137
29039784-5	2017	Furthermore, the findings also demonstrated that 3-MA inhibited the impact of AF/AD on autophagy, Atg5-Atg12 protein complex, Atg7, Atg10, Beclin-1, LC3 I, LC3 II, and DeltaPsim, and promoted the influence of AF/AD on apoptosis and p-P38MAPK in Bel-7402 cells.	3-methyladenine	49-53	beclin 1	Homo sapiens	139-147
29118909-12	2017	After treatment with 3-MA and Beclin 1 knockdown, expression of p-AKT and p-AMPK was significantly reduced.	3-methyladenine	21-25	AKT serine/threonine kinase 1	Homo sapiens	66-69
28857857-11	2017	In addition, 3-MA pretreatment showed no significant influence in the control group, but abrogated the protective role of ISO both in stressed livers (ALT levels, phosphate-buffered saline + ISO versus 3-MA + ISO group, 5081 +- 294 vs 8663 +- 607 U/L, P &lt; .001) and in hepatocytes.	3-methyladenine	13-17	glutamic pyruvic transaminase, soluble	Mus musculus	151-154
28810529-7	2017	SM in presence of zVAD and 3-MA significantly decreased viability and proliferation of HT-29 cells, and expression of RIPK1 and RIPK3 in compare to absence the inhibitors.	3-methyladenine	27-31	receptor interacting serine/threonine kinase 1	Homo sapiens	118-123
27928635-10	2017	In contrast, 3-MA enhanced alpha-SMA expression while inhibiting autophagy.	3-methyladenine	13-17	actin alpha 2, smooth muscle, aorta	Mus musculus	27-36
28863387-7	2017	The levels of caspase-3, -9, -12 expression in both mRNA and protein in oocytes vitrified with 3-methyladenine were significantly higher than that vitrified without 3-methyladenine.	3-methyladenine	95-110	caspase 3	Mus musculus	14-27
28863387-7	2017	The levels of caspase-3, -9, -12 expression in both mRNA and protein in oocytes vitrified with 3-methyladenine were significantly higher than that vitrified without 3-methyladenine.	3-methyladenine	165-180	caspase 3	Mus musculus	14-27
28791376-4	2017	Moreover, MACC1 knockdown inhibited ESCC cell autophagy, and 3-methyladenine was able to rescue MACC1-induced malignant phenotype of ESCC cells.	3-methyladenine	61-76	MET transcriptional regulator MACC1	Homo sapiens	96-101
28582730-8	2017	The autophagy inhibitor 3-MA sensitized resistant HNC cells to RITA treatment via the dual inhibition of molecules related to the autophagy and antioxidant systems.	3-methyladenine	24-28	RBPJ interacting and tubulin associated 1	Mus musculus	63-67
28582730-13	2017	The combined treatment of RITA with the autophagy inhibitor 3-methyladenine overcomes RITA resistance via dual inhibition of autophagy and antioxidant systems in vitro and in vivo.	3-methyladenine	60-75	RBPJ interacting and tubulin associated 1	Mus musculus	86-90
28803810-6	2017	While 3-MA (3-methyladenine, as an autophagy inhibitor) suppressed the Zn-induced changes in the protein expression level of cleaved caspase-3 (CASP3), caspase-8 (CASP8), Cyto C, beclin 1, LC3-II and P62/SQSTM1.	3-methyladenine	6-10	caspase 3	Sus scrofa	144-149
28803810-6	2017	While 3-MA (3-methyladenine, as an autophagy inhibitor) suppressed the Zn-induced changes in the protein expression level of cleaved caspase-3 (CASP3), caspase-8 (CASP8), Cyto C, beclin 1, LC3-II and P62/SQSTM1.	3-methyladenine	6-10	caspase 8	Sus scrofa	152-161
28803810-6	2017	While 3-MA (3-methyladenine, as an autophagy inhibitor) suppressed the Zn-induced changes in the protein expression level of cleaved caspase-3 (CASP3), caspase-8 (CASP8), Cyto C, beclin 1, LC3-II and P62/SQSTM1.	3-methyladenine	6-10	caspase 8	Sus scrofa	163-168
28803810-6	2017	While 3-MA (3-methyladenine, as an autophagy inhibitor) suppressed the Zn-induced changes in the protein expression level of cleaved caspase-3 (CASP3), caspase-8 (CASP8), Cyto C, beclin 1, LC3-II and P62/SQSTM1.	3-methyladenine	6-10	cytochrome c	Sus scrofa	171-177
28803810-6	2017	While 3-MA (3-methyladenine, as an autophagy inhibitor) suppressed the Zn-induced changes in the protein expression level of cleaved caspase-3 (CASP3), caspase-8 (CASP8), Cyto C, beclin 1, LC3-II and P62/SQSTM1.	3-methyladenine	6-10	beclin 1	Sus scrofa	179-187
28803810-6	2017	While 3-MA (3-methyladenine, as an autophagy inhibitor) suppressed the Zn-induced changes in the protein expression level of cleaved caspase-3 (CASP3), caspase-8 (CASP8), Cyto C, beclin 1, LC3-II and P62/SQSTM1.	3-methyladenine	6-10	sequestosome 1	Sus scrofa	204-210
28803810-6	2017	While 3-MA (3-methyladenine, as an autophagy inhibitor) suppressed the Zn-induced changes in the protein expression level of cleaved caspase-3 (CASP3), caspase-8 (CASP8), Cyto C, beclin 1, LC3-II and P62/SQSTM1.	3-methyladenine	12-27	caspase 3	Sus scrofa	144-149
28803810-6	2017	While 3-MA (3-methyladenine, as an autophagy inhibitor) suppressed the Zn-induced changes in the protein expression level of cleaved caspase-3 (CASP3), caspase-8 (CASP8), Cyto C, beclin 1, LC3-II and P62/SQSTM1.	3-methyladenine	12-27	caspase 8	Sus scrofa	152-161
28803810-6	2017	While 3-MA (3-methyladenine, as an autophagy inhibitor) suppressed the Zn-induced changes in the protein expression level of cleaved caspase-3 (CASP3), caspase-8 (CASP8), Cyto C, beclin 1, LC3-II and P62/SQSTM1.	3-methyladenine	12-27	caspase 8	Sus scrofa	163-168
28803810-6	2017	While 3-MA (3-methyladenine, as an autophagy inhibitor) suppressed the Zn-induced changes in the protein expression level of cleaved caspase-3 (CASP3), caspase-8 (CASP8), Cyto C, beclin 1, LC3-II and P62/SQSTM1.	3-methyladenine	12-27	cytochrome c	Sus scrofa	171-177
28803810-6	2017	While 3-MA (3-methyladenine, as an autophagy inhibitor) suppressed the Zn-induced changes in the protein expression level of cleaved caspase-3 (CASP3), caspase-8 (CASP8), Cyto C, beclin 1, LC3-II and P62/SQSTM1.	3-methyladenine	12-27	beclin 1	Sus scrofa	179-187
28803810-6	2017	While 3-MA (3-methyladenine, as an autophagy inhibitor) suppressed the Zn-induced changes in the protein expression level of cleaved caspase-3 (CASP3), caspase-8 (CASP8), Cyto C, beclin 1, LC3-II and P62/SQSTM1.	3-methyladenine	12-27	sequestosome 1	Sus scrofa	204-210
28803810-8	2017	High concentration of Zn up-regulated the relative mRNA expression level of BAX, CYCS, CASP3, CASP8, LC3-II and P62/SQSTM1 genes (p&lt;0.05), which were also ameliorated by 3-MA supplementation.	3-methyladenine	173-177	apoptosis regulator BAX	Sus scrofa	76-79
28963466-3	2017	TNFalpha and IL-1beta induced autophagy markers in human umbilical vein endothelial cells and inhibition of autophagy by 3-methyladenine (3-MA) blocked adhesion of Jurkat lymphocytes.	3-methyladenine	121-136	tumor necrosis factor	Homo sapiens	0-8
28963466-3	2017	TNFalpha and IL-1beta induced autophagy markers in human umbilical vein endothelial cells and inhibition of autophagy by 3-methyladenine (3-MA) blocked adhesion of Jurkat lymphocytes.	3-methyladenine	121-136	interleukin 1 beta	Homo sapiens	13-21
28963466-3	2017	TNFalpha and IL-1beta induced autophagy markers in human umbilical vein endothelial cells and inhibition of autophagy by 3-methyladenine (3-MA) blocked adhesion of Jurkat lymphocytes.	3-methyladenine	138-142	tumor necrosis factor	Homo sapiens	0-8
28963466-3	2017	TNFalpha and IL-1beta induced autophagy markers in human umbilical vein endothelial cells and inhibition of autophagy by 3-methyladenine (3-MA) blocked adhesion of Jurkat lymphocytes.	3-methyladenine	138-142	interleukin 1 beta	Homo sapiens	13-21
28963466-4	2017	Interestingly, 3-MA suppressed VCAM-1 but not ICAM-1 expression at 24 hours but not 6 hours.	3-methyladenine	15-19	vascular cell adhesion molecule 1	Homo sapiens	31-37
28963466-5	2017	3-MA suppressed VCAM-1 transcription and decreased nuclear NF-kappaB p65 level at 6 hours but not at 2 hours.	3-methyladenine	0-4	vascular cell adhesion molecule 1	Homo sapiens	16-22
28963466-5	2017	3-MA suppressed VCAM-1 transcription and decreased nuclear NF-kappaB p65 level at 6 hours but not at 2 hours.	3-methyladenine	0-4	RELA proto-oncogene, NF-kB subunit	Homo sapiens	69-72
28963466-8	2017	With a cytokines array assay, we found that 3-MA also inhibited IP-10 expression.	3-methyladenine	44-48	C-X-C motif chemokine ligand 10	Homo sapiens	64-69
28934130-7	2017	To clarify the role of autophagy and apoptosis in the effect of ISL, we used the autophagy inhibitor-3-methyladenine (3-MA) to attenuate the punctate fluorescence staining pattern of the p62/sequestosome 1 (SQSTM1, red fluorescence) and LC3 (green fluorescence) proteins after ISL treatment, and 3-MA inhibited the cytotoxicity of ISL.	3-methyladenine	101-116	sequestosome 1	Homo sapiens	187-205
28934130-7	2017	To clarify the role of autophagy and apoptosis in the effect of ISL, we used the autophagy inhibitor-3-methyladenine (3-MA) to attenuate the punctate fluorescence staining pattern of the p62/sequestosome 1 (SQSTM1, red fluorescence) and LC3 (green fluorescence) proteins after ISL treatment, and 3-MA inhibited the cytotoxicity of ISL.	3-methyladenine	101-116	sequestosome 1	Homo sapiens	207-213
28934130-7	2017	To clarify the role of autophagy and apoptosis in the effect of ISL, we used the autophagy inhibitor-3-methyladenine (3-MA) to attenuate the punctate fluorescence staining pattern of the p62/sequestosome 1 (SQSTM1, red fluorescence) and LC3 (green fluorescence) proteins after ISL treatment, and 3-MA inhibited the cytotoxicity of ISL.	3-methyladenine	101-116	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	237-240
28934130-7	2017	To clarify the role of autophagy and apoptosis in the effect of ISL, we used the autophagy inhibitor-3-methyladenine (3-MA) to attenuate the punctate fluorescence staining pattern of the p62/sequestosome 1 (SQSTM1, red fluorescence) and LC3 (green fluorescence) proteins after ISL treatment, and 3-MA inhibited the cytotoxicity of ISL.	3-methyladenine	118-122	sequestosome 1	Homo sapiens	187-205
28934130-7	2017	To clarify the role of autophagy and apoptosis in the effect of ISL, we used the autophagy inhibitor-3-methyladenine (3-MA) to attenuate the punctate fluorescence staining pattern of the p62/sequestosome 1 (SQSTM1, red fluorescence) and LC3 (green fluorescence) proteins after ISL treatment, and 3-MA inhibited the cytotoxicity of ISL.	3-methyladenine	118-122	sequestosome 1	Homo sapiens	207-213
28934130-7	2017	To clarify the role of autophagy and apoptosis in the effect of ISL, we used the autophagy inhibitor-3-methyladenine (3-MA) to attenuate the punctate fluorescence staining pattern of the p62/sequestosome 1 (SQSTM1, red fluorescence) and LC3 (green fluorescence) proteins after ISL treatment, and 3-MA inhibited the cytotoxicity of ISL.	3-methyladenine	118-122	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	237-240
28934130-7	2017	To clarify the role of autophagy and apoptosis in the effect of ISL, we used the autophagy inhibitor-3-methyladenine (3-MA) to attenuate the punctate fluorescence staining pattern of the p62/sequestosome 1 (SQSTM1, red fluorescence) and LC3 (green fluorescence) proteins after ISL treatment, and 3-MA inhibited the cytotoxicity of ISL.	3-methyladenine	296-300	sequestosome 1	Homo sapiens	187-205
28979699-6	2017	Furthermore, after treatment with the autophagy inhibitor 3-Methyladenine (3-MA) and autophagy activator rapamycin following SCIR, autophagy in the SCIR-3-MA group decreased significantly, while that in the SCIR-Rap group increased, compared with SCIR-DMSO controls group.	3-methyladenine	58-73	LDL receptor related protein associated protein 1	Rattus norvegicus	212-215
28979699-6	2017	Furthermore, after treatment with the autophagy inhibitor 3-Methyladenine (3-MA) and autophagy activator rapamycin following SCIR, autophagy in the SCIR-3-MA group decreased significantly, while that in the SCIR-Rap group increased, compared with SCIR-DMSO controls group.	3-methyladenine	75-79	LDL receptor related protein associated protein 1	Rattus norvegicus	212-215
28903766-13	2017	Finally, the effects of fluoxetine in NLRP3 inflammasome activation were reversed by additional 3-MA administration.	3-methyladenine	96-100	NLR family, pyrin domain containing 3	Rattus norvegicus	38-43
29113329-5	2017	Furthermore, autophagy stabilization by 3-methyladenine or rapamycin partially suppressed the effects of altered Bmal1 expression on cardiomyocyte survival.	3-methyladenine	40-55	aryl hydrocarbon receptor nuclear translocator-like	Rattus norvegicus	113-118
28984290-7	2017	The autophagy inhibitors, 3-methyladenine (3-MA) and bafilomycin A1, did not affect viral replication, but significantly inhibited the cytotoxicity of RH2.	3-methyladenine	26-41	Rh associated glycoprotein	Homo sapiens	151-154
28984290-7	2017	The autophagy inhibitors, 3-methyladenine (3-MA) and bafilomycin A1, did not affect viral replication, but significantly inhibited the cytotoxicity of RH2.	3-methyladenine	43-47	Rh associated glycoprotein	Homo sapiens	151-154
28859361-8	2017	Furthermore, the administration of the autophagic inhibitor 3-methyladenine (3-MA) could augment BNIP3-induced cell apoptosis and death, suggesting that autophagy plays a protective role under hypoxia.	3-methyladenine	60-75	BCL2 interacting protein 3	Homo sapiens	97-102
28859361-8	2017	Furthermore, the administration of the autophagic inhibitor 3-methyladenine (3-MA) could augment BNIP3-induced cell apoptosis and death, suggesting that autophagy plays a protective role under hypoxia.	3-methyladenine	77-81	BCL2 interacting protein 3	Homo sapiens	97-102
28655725-5	2017	Autophagy inhibition by 3-methyladenine (3-MA) in palmitate-treated cells neither increased SQSTMI/p62 accumulation nor cell death, thus suggesting complete blockade of autophagy by palmitate.	3-methyladenine	41-45	sequestosome 1	Homo sapiens	99-102
28759800-7	2017	Moreover, autophagy inhibitor chloroquine (CQ) or 3-Methyladenine (3MA) treatment significantly suppressed phosphorylation and consequently degradation of NF-kappaB inhibitor I-kappaBalpha, reduced MM-MSCs-mediate activation of NF-kappaB and prevented MM-MSCs-induced resistance.	3-methyladenine	50-65	nuclear factor kappa B subunit 1	Homo sapiens	155-164
28759800-7	2017	Moreover, autophagy inhibitor chloroquine (CQ) or 3-Methyladenine (3MA) treatment significantly suppressed phosphorylation and consequently degradation of NF-kappaB inhibitor I-kappaBalpha, reduced MM-MSCs-mediate activation of NF-kappaB and prevented MM-MSCs-induced resistance.	3-methyladenine	50-65	NFKB inhibitor alpha	Homo sapiens	175-188
28759800-7	2017	Moreover, autophagy inhibitor chloroquine (CQ) or 3-Methyladenine (3MA) treatment significantly suppressed phosphorylation and consequently degradation of NF-kappaB inhibitor I-kappaBalpha, reduced MM-MSCs-mediate activation of NF-kappaB and prevented MM-MSCs-induced resistance.	3-methyladenine	50-65	nuclear factor kappa B subunit 1	Homo sapiens	228-237
28759800-7	2017	Moreover, autophagy inhibitor chloroquine (CQ) or 3-Methyladenine (3MA) treatment significantly suppressed phosphorylation and consequently degradation of NF-kappaB inhibitor I-kappaBalpha, reduced MM-MSCs-mediate activation of NF-kappaB and prevented MM-MSCs-induced resistance.	3-methyladenine	67-70	nuclear factor kappa B subunit 1	Homo sapiens	155-164
28759800-7	2017	Moreover, autophagy inhibitor chloroquine (CQ) or 3-Methyladenine (3MA) treatment significantly suppressed phosphorylation and consequently degradation of NF-kappaB inhibitor I-kappaBalpha, reduced MM-MSCs-mediate activation of NF-kappaB and prevented MM-MSCs-induced resistance.	3-methyladenine	67-70	NFKB inhibitor alpha	Homo sapiens	175-188
28759800-7	2017	Moreover, autophagy inhibitor chloroquine (CQ) or 3-Methyladenine (3MA) treatment significantly suppressed phosphorylation and consequently degradation of NF-kappaB inhibitor I-kappaBalpha, reduced MM-MSCs-mediate activation of NF-kappaB and prevented MM-MSCs-induced resistance.	3-methyladenine	67-70	nuclear factor kappa B subunit 1	Homo sapiens	228-237
28714008-8	2017	In contrast, after autophagy inhibited by 3-methyladenine, chondrocyte apoptosis was further increased under IL-1beta treatment.	3-methyladenine	42-57	interleukin 1 beta	Homo sapiens	109-117
28927113-7	2017	In addition, inhibition of autophagy by 3-methyladenine resulted in a marked enhancement of the proliferation inhibition effect of miR-7.	3-methyladenine	40-55	leukocyte immunoglobulin like receptor B1	Homo sapiens	131-136
28872080-14	2017	Compared with the allicin treatment group, the 7 d survival rate, lung SOD activity, and the expressions of LC3B and Beclin-1 were decreased in the 3-MA group (P&lt;0.05); the lung morphological damage scores, the levels of TNF-alpha and IL-6 in the BALF, and MDA content in the lung were increased significantly in the 3-MA group (P&lt;0.05).	3-methyladenine	148-152	microtubule-associated protein 1 light chain 3 beta	Mus musculus	108-112
28872080-14	2017	Compared with the allicin treatment group, the 7 d survival rate, lung SOD activity, and the expressions of LC3B and Beclin-1 were decreased in the 3-MA group (P&lt;0.05); the lung morphological damage scores, the levels of TNF-alpha and IL-6 in the BALF, and MDA content in the lung were increased significantly in the 3-MA group (P&lt;0.05).	3-methyladenine	148-152	beclin 1, autophagy related	Mus musculus	117-125
28872080-14	2017	Compared with the allicin treatment group, the 7 d survival rate, lung SOD activity, and the expressions of LC3B and Beclin-1 were decreased in the 3-MA group (P&lt;0.05); the lung morphological damage scores, the levels of TNF-alpha and IL-6 in the BALF, and MDA content in the lung were increased significantly in the 3-MA group (P&lt;0.05).	3-methyladenine	148-152	tumor necrosis factor	Mus musculus	224-233
28872080-14	2017	Compared with the allicin treatment group, the 7 d survival rate, lung SOD activity, and the expressions of LC3B and Beclin-1 were decreased in the 3-MA group (P&lt;0.05); the lung morphological damage scores, the levels of TNF-alpha and IL-6 in the BALF, and MDA content in the lung were increased significantly in the 3-MA group (P&lt;0.05).	3-methyladenine	148-152	interleukin 6	Mus musculus	238-242
28825103-13	2017	The inhibitor of autophagy, 3-MA, reduced TXNIP overexpression-induced apoptosis in INS-1 cells.	3-methyladenine	28-32	thioredoxin interacting protein	Rattus norvegicus	42-47
28825103-13	2017	The inhibitor of autophagy, 3-MA, reduced TXNIP overexpression-induced apoptosis in INS-1 cells.	3-methyladenine	28-32	insulin 1	Rattus norvegicus	84-89
28883791-5	2017	The reduction in gp130 and JAK2 can be restored by co-treatment with 3-methyladenine, an early-stage autophagy lysosome and type I/III PI3K inhibitor.	3-methyladenine	69-84	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	17-22
28883791-5	2017	The reduction in gp130 and JAK2 can be restored by co-treatment with 3-methyladenine, an early-stage autophagy lysosome and type I/III PI3K inhibitor.	3-methyladenine	69-84	Janus kinase 2	Homo sapiens	27-31
28808311-10	2017	Contrary, inhibition of autophagy by 3-MA/CQ potentiated CoQ0-induced apoptosis (increased DNA fragmentation/PARP cleavage).	3-methyladenine	37-41	collagen type XI alpha 2 chain	Homo sapiens	109-113
28528119-7	2017	Specifically, the mTOR-dependent autophagy inducer rapamycin enhanced the knockdown efficiency of both lipoplex and polyplex, whereas mTOR-dependent autophagy inhibitor 3-methyladenine (3-MA) suppressed their silencing efficiency.	3-methyladenine	169-184	mechanistic target of rapamycin kinase	Homo sapiens	134-138
28528119-7	2017	Specifically, the mTOR-dependent autophagy inducer rapamycin enhanced the knockdown efficiency of both lipoplex and polyplex, whereas mTOR-dependent autophagy inhibitor 3-methyladenine (3-MA) suppressed their silencing efficiency.	3-methyladenine	186-190	mechanistic target of rapamycin kinase	Homo sapiens	134-138
28528119-16	2017	Specifically, the mTOR-dependent autophagy inducer rapamycin enhances the knockdown efficiency of both lipoplex and polyplex, whereas mTOR-dependent autophagy inhibitor 3-methyladenine suppresses their silencing efficiency.	3-methyladenine	169-184	mechanistic target of rapamycin kinase	Homo sapiens	134-138
28549968-5	2017	Moreover, the OGD/R-induced upregulation of mRNA and protein expressions of GluR1, GluR2, and GluR3 were also effectively reversed in cells pretreated with 3-MA.	3-methyladenine	156-160	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	76-81
28549968-5	2017	Moreover, the OGD/R-induced upregulation of mRNA and protein expressions of GluR1, GluR2, and GluR3 were also effectively reversed in cells pretreated with 3-MA.	3-methyladenine	156-160	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	83-88
28549968-5	2017	Moreover, the OGD/R-induced upregulation of mRNA and protein expressions of GluR1, GluR2, and GluR3 were also effectively reversed in cells pretreated with 3-MA.	3-methyladenine	156-160	glutamate ionotropic receptor AMPA type subunit 3	Homo sapiens	94-99
28549968-6	2017	Our findings indicate that OGD/R induced the expression of GluRs by activating autophagy in in vitro cultured hippocampal neurons, which could be effectively reversed by the administration of 3-MA.	3-methyladenine	192-196	glutamyl-tRNA synthetase 2, mitochondrial	Homo sapiens	59-64
28506929-6	2017	The compound 3-methyladenine (3-MA), an inhibitor of autophagy, largely rescues autophagy and the inhibition of cell proliferation induced by KDM2B knockdown.	3-methyladenine	13-28	lysine demethylase 2B	Homo sapiens	142-147
28506929-6	2017	The compound 3-methyladenine (3-MA), an inhibitor of autophagy, largely rescues autophagy and the inhibition of cell proliferation induced by KDM2B knockdown.	3-methyladenine	30-34	lysine demethylase 2B	Homo sapiens	142-147
28537760-11	2017	Furthermore, the cardiomyocyte hypertrophy index brain natriuretic peptide (BNP) induced by apelin-13 was blunt by F13A or autophagy inhibitor 3-methyladenine and further promoted by caveolin inhibitor.	3-methyladenine	143-158	natriuretic peptide B	Rattus norvegicus	49-74
28537760-11	2017	Furthermore, the cardiomyocyte hypertrophy index brain natriuretic peptide (BNP) induced by apelin-13 was blunt by F13A or autophagy inhibitor 3-methyladenine and further promoted by caveolin inhibitor.	3-methyladenine	143-158	natriuretic peptide B	Rattus norvegicus	76-79
28537760-11	2017	Furthermore, the cardiomyocyte hypertrophy index brain natriuretic peptide (BNP) induced by apelin-13 was blunt by F13A or autophagy inhibitor 3-methyladenine and further promoted by caveolin inhibitor.	3-methyladenine	143-158	apelin	Rattus norvegicus	92-98
28579546-6	2017	Autophagy inhibitor 3-methyladenine (3MA) attenuated MEHP-induced LMP and the release of cathepsin B in EA.hy 926 cells.	3-methyladenine	20-35	cathepsin B	Homo sapiens	89-100
28634253-10	2017	In contrast, 3-MA, which is an autophagy inhibitor, caused an exaggerated induction of TNF-alpha-induced apoptosis.	3-methyladenine	13-17	tumor necrosis factor	Mus musculus	87-96
28634253-14	2017	TNF-alpha-mediated induction of cleaved caspase-3 was downregulated by rapamycin, but upregulated by 3-MA, respectively.	3-methyladenine	101-105	tumor necrosis factor	Mus musculus	0-9
28634253-14	2017	TNF-alpha-mediated induction of cleaved caspase-3 was downregulated by rapamycin, but upregulated by 3-MA, respectively.	3-methyladenine	101-105	caspase 3	Mus musculus	40-49
28779993-4	2017	The results showed that S14161 induced autophagy as demonstrated by increased LC3-II and decreased p62, which were prevented by autophagy inhibitors including 3-methyladenine and bafilomycin A1.	3-methyladenine	159-174	nucleoporin 62	Homo sapiens	99-102
28497346-9	2017	In the presence of the inhibitor of autophagy (3-methyladenine; 3-MA), the protective effect of GM1 on PC12 cells in Abeta (1-42) induced toxic conditions was diminished.	3-methyladenine	47-62	coenzyme Q10A	Mus musculus	96-99
28497346-9	2017	In the presence of the inhibitor of autophagy (3-methyladenine; 3-MA), the protective effect of GM1 on PC12 cells in Abeta (1-42) induced toxic conditions was diminished.	3-methyladenine	64-68	coenzyme Q10A	Mus musculus	96-99
28677738-5	2017	Autophagy-specific inhibitor 3-MA reduce sodium cantharidinate-induced caspase-3 activity and HepG2 cell apoptosis.	3-methyladenine	29-33	caspase 3	Homo sapiens	71-80
28624177-5	2017	In contrast, light chain 3 II and beclin-1 levels were significantly less and those of cleaved caspase-3 significantly greater in the 3-methyladenine group.	3-methyladenine	134-149	beclin 1, autophagy related	Mus musculus	34-42
28763891-3	2017	Result: Silencing JWA gene increased the sensitivity of TE1 cells to cisplatin (P&lt;0.05), and decreased the LC3-I and LC3-II proteins induced by cisplatin.Furthermore, combined with 3-MA increased the inhibition rate of cisplatin in JWA silencing group (P&lt;0.05).	3-methyladenine	184-188	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	18-21
28744393-6	2017	Pharmacological treatment with either 3-methyladenine to inhibit autophagy or with rapamycin to activate autophagy in these two cisplatin-resistant sublines resulted in the accumulation or degradation of FOXO3a, respectively.	3-methyladenine	38-53	forkhead box O3	Homo sapiens	204-210
28315413-11	2017	The elevated methylmercury sensitivity by Meh1 knockout almost completely disappeared in the presence of 3-methyladenine.	3-methyladenine	105-120	Meh1p	Saccharomyces cerevisiae S288C	42-46
27714857-4	2017	The inhibition of autophagy by 3-methyladenine treatment or ATG5 knockdown effectively recovered premelanosome protein as well as tyrosinase degraded by the beta-mangostin treatment.	3-methyladenine	31-46	tyrosinase	Homo sapiens	130-140
28396174-7	2017	In addition, the autophagy inhibitor 3-MA and bafilomycin A1 partially prevented the effects of Sirt3 on LDH release and apoptosis after OGD.	3-methyladenine	37-41	sirtuin 3	Homo sapiens	96-101
28473248-9	2017	Moreover, autophagy inhibitor 3-MA could simulate the effects of TSC2 siRNA while autophagy inducer rapamycin could mimic the effects of raptor siRNA, suggesting that the beneficial effects of mTORC1 deletion were associated with autophagy induction.	3-methyladenine	30-34	TSC complex subunit 2	Mus musculus	65-69
28617316-5	2017	Interestingly, pretreatment with 3-methyl adenine, a pharmacological inhibitor of autophagy, abrogated the suppressive effects of gAcrp on IL-1beta secretion and caspase-1 activation, indicating the crucial role of autophagy induction in gAcrp-modulation of the inflammasome activation.	3-methyladenine	33-49	interleukin 1 beta	Mus musculus	139-147
28617316-5	2017	Interestingly, pretreatment with 3-methyl adenine, a pharmacological inhibitor of autophagy, abrogated the suppressive effects of gAcrp on IL-1beta secretion and caspase-1 activation, indicating the crucial role of autophagy induction in gAcrp-modulation of the inflammasome activation.	3-methyladenine	33-49	caspase 1	Mus musculus	162-171
28659924-7	2017	Consistently, the addition of 3-MA, an inhibitor of LC3-related autophagy, partially restored macrophage polarization.	3-methyladenine	30-34	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	52-55
28659924-8	2017	Intriguingly, we also found that the upregulation of LC3B expression by rapamycin and heat-killed Brucella in vitro inhibits M2 macrophage polarization, which can be reversed partially by 3-MA.	3-methyladenine	188-192	microtubule associated protein 1 light chain 3 beta	Homo sapiens	53-57
28594401-5	2017	The autophagy inhibitor 3-methyladenine and an ATG5 siRNA significantly attenuated PDT-induced autophagy, which subsequently suppressed the ABCA1-mediated cholesterol efflux.	3-methyladenine	24-39	ATP binding cassette subfamily A member 1	Homo sapiens	140-145
28402166-6	2017	Effect of 3-MA (a classical inhibitor of autophagy) on 95D-Nrf2 cells was also analyzed using flow cytometry.	3-methyladenine	10-14	NFE2 like bZIP transcription factor 2	Homo sapiens	59-63
28678325-5	2017	Autophagy inhibitor 3-methyladenine (3-MA) could reverse TGF-beta1 induced autophagy process.	3-methyladenine	20-35	transforming growth factor beta 1	Homo sapiens	57-66
28678325-5	2017	Autophagy inhibitor 3-methyladenine (3-MA) could reverse TGF-beta1 induced autophagy process.	3-methyladenine	37-41	transforming growth factor beta 1	Homo sapiens	57-66
28678325-6	2017	Also, TGF-beta1 significantly promotes the invasion ability of HepG2 cells; however, this process could effectively reverse by autophagy inhibitor 3-MA.	3-methyladenine	147-151	transforming growth factor beta 1	Homo sapiens	6-15
29442026-4	2017	Here, the expression level of P63 in the articular cartilages of OA patients and chondrocytes treated with 3-MA was explored using western blot.	3-methyladenine	107-111	tumor protein p63	Homo sapiens	30-33
28635401-8	2017	Compared with the blank group, light chain 3 and Beclin 1 expressions were increased in the siROR + Tamoxifen group but decreased in the 3-methyladenine + Tamoxifen group; these data indicated that downregulated long non-coding RNA ROR promoted autophagy.	3-methyladenine	137-152	beclin 1	Homo sapiens	49-57
28635401-10	2017	Compared with the Tamoxifen, negative control, and siROR + 3-methyladenine + Tamoxifen groups, the cell proliferation, invasion, and migration in the siROR + Tamoxifen group were much decreased; these results implied that downregulated long non-coding RNA ROR suppressed BT474 cell proliferation, invasion, and migration and reversed the effect of Tamoxifen on the BT474 cells.	3-methyladenine	59-74	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	53-56
30460066-3	2017	The autophagy inhibitor 3-MA increased the steady-state level of ataxin-3 and stabilized SUMO-modified ataxin-3 more prominently than the proteasome inhibitor MG132.	3-methyladenine	24-28	ataxin 3	Homo sapiens	65-73
30460066-3	2017	The autophagy inhibitor 3-MA increased the steady-state level of ataxin-3 and stabilized SUMO-modified ataxin-3 more prominently than the proteasome inhibitor MG132.	3-methyladenine	24-28	ataxin 3	Homo sapiens	103-111
28546552-9	2017	Conversely, 3-MA, an autophagy inhibitor, reversed these beneficial effects of melatonin on mitophagy and the NLRP3 inflammasome.	3-methyladenine	12-16	NLR family, pyrin domain containing 3	Rattus norvegicus	110-115
28404768-7	2017	The DJ-1 overexpression-mediated preservation of HPO-induced cardioprotection was completely inhibited by the AMPK inhibitor compound C (CC) and the autophagy inhibitor 3-MA (3-methyladenine).	3-methyladenine	169-173	Parkinsonism associated deglycase	Rattus norvegicus	4-8
28404768-7	2017	The DJ-1 overexpression-mediated preservation of HPO-induced cardioprotection was completely inhibited by the AMPK inhibitor compound C (CC) and the autophagy inhibitor 3-MA (3-methyladenine).	3-methyladenine	175-190	Parkinsonism associated deglycase	Rattus norvegicus	4-8
28213588-8	2017	Interestingly, we found that ALS-hMSC death in response to induction of DSBs was dependent on autophagy, which was initialized by an increase of phosphorylated (p)AMPK, and blocked by the class III phosphoinositide 3-kinase (PI3K) and autophagy inhibitor 3-methyladenine (3MeA).	3-methyladenine	255-270	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	198-223
28390259-5	2017	We here found that the cytotoxicity induced by anti-EGFR-GNs-combined NIR-PTT was rescued by treatment with autophagy inhibitor, 3-methyladenine (3-MA).	3-methyladenine	129-144	epidermal growth factor receptor	Homo sapiens	52-56
28390259-5	2017	We here found that the cytotoxicity induced by anti-EGFR-GNs-combined NIR-PTT was rescued by treatment with autophagy inhibitor, 3-methyladenine (3-MA).	3-methyladenine	146-150	epidermal growth factor receptor	Homo sapiens	52-56
28502292-9	2017	Meanwhile, 3-MA or rapamycin pretreatment further regulated the protein expressions of IkappaBalpha and p-NF-kBp65 induced by LPS in macrophages.	3-methyladenine	11-15	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	87-99
28445931-8	2017	The autophagy inhibitor 3-MA increased the injury in Bim knockdown HK2 cells by retriggering apoptosis.	3-methyladenine	24-28	BCL2 like 11	Homo sapiens	53-56
28245985-6	2017	Inhibition of autophagy by 3-MA exacerbates cytotoxicity induced by LPS in A549 alveolar epithelial cells.	3-methyladenine	27-31	toll-like receptor 4	Mus musculus	68-71
28157209-10	2017	Consistently, treatment with 3-MA inhibited K63-linked ubiquitination of TRAF6 in I/R-injured lung tissues in vivo.	3-methyladenine	29-33	LOC222344	Homo sapiens	73-78
28682541-13	2017	Apoptosis of osteoblasts increased after 3-MA pretreatment, and CGRP reversed inhibitory effects of 3-MA CGRP on apoptosis.	3-methyladenine	41-45	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	105-109
28408883-8	2017	An autophagy inhibitor, 3-methyladenine, could partially reverse cell viability and conversely change the ratio of LC3II/LC3I and the protein expression of Bcl-2 and Kim-1.	3-methyladenine	24-39	BCL2 apoptosis regulator	Homo sapiens	156-161
28408883-8	2017	An autophagy inhibitor, 3-methyladenine, could partially reverse cell viability and conversely change the ratio of LC3II/LC3I and the protein expression of Bcl-2 and Kim-1.	3-methyladenine	24-39	hepatitis A virus cellular receptor 1	Homo sapiens	166-171
28446285-6	2017	While combining with autophagy inhibitor 3-MA, both the Beclin1 mRNA expression level and the LC3II/I ratio were declined continually during the treated period.	3-methyladenine	41-45	beclin 1	Homo sapiens	56-63
28386319-12	2017	Treatment with 3-methyladenine (3-MA) mitigated autophagy activation and reversed the inhibitory effect of THC on the translocation of Bax to the mitochondrial membrane.	3-methyladenine	15-30	BCL2 associated X, apoptosis regulator	Rattus norvegicus	135-138
28386319-12	2017	Treatment with 3-methyladenine (3-MA) mitigated autophagy activation and reversed the inhibitory effect of THC on the translocation of Bax to the mitochondrial membrane.	3-methyladenine	32-36	BCL2 associated X, apoptosis regulator	Rattus norvegicus	135-138
28188848-11	2017	Moreover, 3-MA increased the apoptosis and the expression of TNF-alpha, IL-1beta, and MMP-9.	3-methyladenine	10-14	tumor necrosis factor	Rattus norvegicus	61-70
28188848-11	2017	Moreover, 3-MA increased the apoptosis and the expression of TNF-alpha, IL-1beta, and MMP-9.	3-methyladenine	10-14	interleukin 1 beta	Rattus norvegicus	72-80
28188848-11	2017	Moreover, 3-MA increased the apoptosis and the expression of TNF-alpha, IL-1beta, and MMP-9.	3-methyladenine	10-14	matrix metallopeptidase 9	Rattus norvegicus	86-91
26983718-9	2017	After short-term OGD (1, 4 h), cells treated with 3-MA showed higher level of cleaved caspase 3 compared with control cells.	3-methyladenine	50-54	caspase 3	Rattus norvegicus	86-95
28338195-5	2017	Autophagy inhibitor 3-MA could inhibit TGF-b1 upregulated autophagy.	3-methyladenine	20-24	transforming growth factor beta 1	Homo sapiens	39-45
28038796-9	2017	The differences in the activation and apoptosis between CyPA silent cells and the control cells were inhibited by pre-treatment with class III PI 3-kinase inhibitor 3-MA.	3-methyladenine	165-169	peptidylprolyl isomerase A	Mus musculus	56-60
28197638-10	2017	Interestingly, pretreatment with 3-MA and chloroquine remarkably suppressed CoCl2-induced caspase-3 activation and cell apoptosis.	3-methyladenine	33-37	caspase 3	Homo sapiens	90-99
28138700-11	2017	Furthermore, the autophagy inhibitor 3-methyladenine and miR-410 expression were able to improve the therapeutic response of the cells to chemotherapy drugs (rapamycin, doxorubicin and cisplatin), thus indicating that miR-410 enhanced chemosensitivity through autophagy inhibition in osteosarcoma cells.	3-methyladenine	37-52	microRNA 410	Homo sapiens	218-225
28469656-7	2017	Additionally, 3-methyladenine pretreatment blocked the hypoxia-ischemia-induced upregulation of GluR1 and downregulation of GluR2 in the hippocampus.	3-methyladenine	14-29	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	96-101
28469656-7	2017	Additionally, 3-methyladenine pretreatment blocked the hypoxia-ischemia-induced upregulation of GluR1 and downregulation of GluR2 in the hippocampus.	3-methyladenine	14-29	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	124-129
28612524-8	2017	Exposure to 3-MA was also associated with lower expressions of LC3 and Beclin1, with HepG2 cells showing typical apoptotic characteristics.	3-methyladenine	12-16	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	63-66
28612524-8	2017	Exposure to 3-MA was also associated with lower expressions of LC3 and Beclin1, with HepG2 cells showing typical apoptotic characteristics.	3-methyladenine	12-16	beclin 1	Homo sapiens	71-78
28206988-6	2017	Immunofluorescence analysis showed that 3-MA or Wort treatment reversed OGD-induced release of cathepsin B and L from the lysosome to the cytoplasm and activation of caspase-3 in the astrocytes.	3-methyladenine	40-44	cathepsin B	Rattus norvegicus	95-106
28206988-6	2017	Immunofluorescence analysis showed that 3-MA or Wort treatment reversed OGD-induced release of cathepsin B and L from the lysosome to the cytoplasm and activation of caspase-3 in the astrocytes.	3-methyladenine	40-44	caspase 3	Rattus norvegicus	166-175
30090501-8	2017	In addition, inhibition of autophagy by 3-methyladenine (3-MA) partially suppressed the cytotoxicity induced by GANT61-induced inhibition of Gli2.	3-methyladenine	40-55	GLI family zinc finger 2	Homo sapiens	141-145
30090501-8	2017	In addition, inhibition of autophagy by 3-methyladenine (3-MA) partially suppressed the cytotoxicity induced by GANT61-induced inhibition of Gli2.	3-methyladenine	57-61	GLI family zinc finger 2	Homo sapiens	141-145
28031531-5	2017	Inhibiting the autophagy generation by 3-methyladenine (3-MA) increase cell viability but decrease the caspase 3/7 and caspase 8 activities in combination groups, and inhibiting apoptosis took the same effect.	3-methyladenine	39-54	caspase 3	Homo sapiens	103-112
28031531-5	2017	Inhibiting the autophagy generation by 3-methyladenine (3-MA) increase cell viability but decrease the caspase 3/7 and caspase 8 activities in combination groups, and inhibiting apoptosis took the same effect.	3-methyladenine	39-54	caspase 8	Homo sapiens	119-128
28031531-5	2017	Inhibiting the autophagy generation by 3-methyladenine (3-MA) increase cell viability but decrease the caspase 3/7 and caspase 8 activities in combination groups, and inhibiting apoptosis took the same effect.	3-methyladenine	56-60	caspase 3	Homo sapiens	103-112
28031531-5	2017	Inhibiting the autophagy generation by 3-methyladenine (3-MA) increase cell viability but decrease the caspase 3/7 and caspase 8 activities in combination groups, and inhibiting apoptosis took the same effect.	3-methyladenine	56-60	caspase 8	Homo sapiens	119-128
28025121-6	2017	The autophagy inhibitor 3-methyladenine (3-MA) markedly decreased the expression of the autophagy marker beclin-1, microtubule-associated protein light chain 3-II (LC3II), p62/sequestosome 1 (SQSTM1) degradation, and promoted apoptosis.	3-methyladenine	24-39	beclin 1	Homo sapiens	105-169
28025121-6	2017	The autophagy inhibitor 3-methyladenine (3-MA) markedly decreased the expression of the autophagy marker beclin-1, microtubule-associated protein light chain 3-II (LC3II), p62/sequestosome 1 (SQSTM1) degradation, and promoted apoptosis.	3-methyladenine	24-39	sequestosome 1	Homo sapiens	172-190
28025121-6	2017	The autophagy inhibitor 3-methyladenine (3-MA) markedly decreased the expression of the autophagy marker beclin-1, microtubule-associated protein light chain 3-II (LC3II), p62/sequestosome 1 (SQSTM1) degradation, and promoted apoptosis.	3-methyladenine	24-39	sequestosome 1	Homo sapiens	192-198
28025121-6	2017	The autophagy inhibitor 3-methyladenine (3-MA) markedly decreased the expression of the autophagy marker beclin-1, microtubule-associated protein light chain 3-II (LC3II), p62/sequestosome 1 (SQSTM1) degradation, and promoted apoptosis.	3-methyladenine	41-45	beclin 1	Homo sapiens	105-169
28025121-6	2017	The autophagy inhibitor 3-methyladenine (3-MA) markedly decreased the expression of the autophagy marker beclin-1, microtubule-associated protein light chain 3-II (LC3II), p62/sequestosome 1 (SQSTM1) degradation, and promoted apoptosis.	3-methyladenine	41-45	sequestosome 1	Homo sapiens	172-190
28025121-6	2017	The autophagy inhibitor 3-methyladenine (3-MA) markedly decreased the expression of the autophagy marker beclin-1, microtubule-associated protein light chain 3-II (LC3II), p62/sequestosome 1 (SQSTM1) degradation, and promoted apoptosis.	3-methyladenine	41-45	sequestosome 1	Homo sapiens	192-198
28456145-10	2017	Pretreatment of cells with 3-methyladenine evidently downregulated LC3 II expression and aggravated PC12 cell death under high lipid conditions.	3-methyladenine	27-42	annexin A3	Rattus norvegicus	67-70
28017719-7	2017	Importantly, suppressing autophagy pathway with 3-MA alleviated the protective roles of miR-217 down-regulation in podocyte injury and insulin resistance.	3-methyladenine	48-52	microRNA 217	Homo sapiens	88-95
28017719-7	2017	Importantly, suppressing autophagy pathway with 3-MA alleviated the protective roles of miR-217 down-regulation in podocyte injury and insulin resistance.	3-methyladenine	48-52	insulin	Homo sapiens	135-142
27817185-4	2017	Correspondingly, concomitant treatment with the autophagy inhibitor (3-methyladenine or LY294002) appeared to enhance acacetin-induced apoptotic responses, such as Bak activation, Deltapsi loss, activation of caspase-9 and caspase-3, and apoptotic sub-G1 accumulation.	3-methyladenine	69-84	BCL2 antagonist/killer 1	Homo sapiens	164-167
27817185-4	2017	Correspondingly, concomitant treatment with the autophagy inhibitor (3-methyladenine or LY294002) appeared to enhance acacetin-induced apoptotic responses, such as Bak activation, Deltapsi loss, activation of caspase-9 and caspase-3, and apoptotic sub-G1 accumulation.	3-methyladenine	69-84	caspase 9	Homo sapiens	209-218
27817185-4	2017	Correspondingly, concomitant treatment with the autophagy inhibitor (3-methyladenine or LY294002) appeared to enhance acacetin-induced apoptotic responses, such as Bak activation, Deltapsi loss, activation of caspase-9 and caspase-3, and apoptotic sub-G1 accumulation.	3-methyladenine	69-84	caspase 3	Homo sapiens	223-232
28120948-7	2017	However, pretreatment with the autophagy inhibitor 3-methyladenine showed the potential in further elevating the apoptosis rate induced by IL-1beta in NP cells.	3-methyladenine	51-66	interleukin 1 beta	Homo sapiens	139-147
28106723-6	2017	Further research using 3-methyladenine (3-MA), bafilomycin A1, and ad-mCherry-GFP-LC3B adenovirus demonstrated that LC3B-II increase induced by TNF-alpha was attributed to the inhibition of autophagic degradation.	3-methyladenine	23-38	microtubule associated protein 1 light chain 3 beta	Homo sapiens	116-120
28106723-6	2017	Further research using 3-methyladenine (3-MA), bafilomycin A1, and ad-mCherry-GFP-LC3B adenovirus demonstrated that LC3B-II increase induced by TNF-alpha was attributed to the inhibition of autophagic degradation.	3-methyladenine	23-38	tumor necrosis factor	Homo sapiens	144-153
28106723-6	2017	Further research using 3-methyladenine (3-MA), bafilomycin A1, and ad-mCherry-GFP-LC3B adenovirus demonstrated that LC3B-II increase induced by TNF-alpha was attributed to the inhibition of autophagic degradation.	3-methyladenine	40-44	microtubule associated protein 1 light chain 3 beta	Homo sapiens	116-120
28106723-6	2017	Further research using 3-methyladenine (3-MA), bafilomycin A1, and ad-mCherry-GFP-LC3B adenovirus demonstrated that LC3B-II increase induced by TNF-alpha was attributed to the inhibition of autophagic degradation.	3-methyladenine	40-44	tumor necrosis factor	Homo sapiens	144-153
28046018-8	2017	Joint application of 3-MA or Atg7 siRNA enhanced the cell growth inhibition and apoptosis effects of NVP-AEW541 by arresting cells at G1/G0 phase and increasing Bax expression and decreasing that of Bcl-2.	3-methyladenine	21-25	BCL2 associated X, apoptosis regulator	Homo sapiens	161-164
28046018-8	2017	Joint application of 3-MA or Atg7 siRNA enhanced the cell growth inhibition and apoptosis effects of NVP-AEW541 by arresting cells at G1/G0 phase and increasing Bax expression and decreasing that of Bcl-2.	3-methyladenine	21-25	BCL2 apoptosis regulator	Homo sapiens	199-204
29049987-10	2017	In addition, ATR inhibited autophagy, whereas isoflavones induced autophagy through the accumulation of LC3-II and decreased expression of p62; this effect was abolished by 3-methyladenine (3-MA).	3-methyladenine	173-188	nucleoporin 62	Homo sapiens	139-142
29049987-10	2017	In addition, ATR inhibited autophagy, whereas isoflavones induced autophagy through the accumulation of LC3-II and decreased expression of p62; this effect was abolished by 3-methyladenine (3-MA).	3-methyladenine	190-194	nucleoporin 62	Homo sapiens	139-142
29234448-7	2017	In contrast, the inhibition of autophagy by autophagy inhibitor, 3-methyladenine, or by knockdown of Beclin 1 led to an attenuation of EMT and downregulated expression of fibronectin in AA-treated HKC cells.	3-methyladenine	65-80	fibronectin 1	Homo sapiens	171-182
29358849-7	2017	Pharmacological inhibition of autophagy with 3-methyladenine enhanced Mfn2 overexpression-induced cell apoptosis.	3-methyladenine	45-60	mitofusin 2	Homo sapiens	70-74
27197615-5	2016	Induction of mtDNA damage (with the autophagy inhibitor, 3-methyladenine, or DNase II inhibition) enhanced PCSK9 expression, and inhibition of mtDNA damage (with the autophagy inducer, rapamycin) reduced PCSK9 expression, indicating bidirectional interplay between PCSK9 and mtDNA damage.	3-methyladenine	57-72	proprotein convertase subtilisin/kexin type 9	Homo sapiens	107-112
27793667-6	2016	Autophagy was even induced upon TLR9 activation after inhibiting recruitment of initial autophagy components by 3-MA, a specific inhibitor of class III PI3-kinase.	3-methyladenine	112-116	toll like receptor 9	Homo sapiens	32-36
27811372-5	2016	Moreover, blocking autophagy using pharmacological inhibitors 3-methyladenine (3-MA) and chloroquine (CQ) enhanced Ru1-induced apoptosis, indicating the cytoprotective role of autophagy in Ru1-treated A549 and NCI-H460 cells.	3-methyladenine	62-77	Scm like with four mbt domains 1	Homo sapiens	115-118
27811372-5	2016	Moreover, blocking autophagy using pharmacological inhibitors 3-methyladenine (3-MA) and chloroquine (CQ) enhanced Ru1-induced apoptosis, indicating the cytoprotective role of autophagy in Ru1-treated A549 and NCI-H460 cells.	3-methyladenine	62-77	Scm like with four mbt domains 1	Homo sapiens	189-192
27811372-5	2016	Moreover, blocking autophagy using pharmacological inhibitors 3-methyladenine (3-MA) and chloroquine (CQ) enhanced Ru1-induced apoptosis, indicating the cytoprotective role of autophagy in Ru1-treated A549 and NCI-H460 cells.	3-methyladenine	79-83	Scm like with four mbt domains 1	Homo sapiens	115-118
27811372-5	2016	Moreover, blocking autophagy using pharmacological inhibitors 3-methyladenine (3-MA) and chloroquine (CQ) enhanced Ru1-induced apoptosis, indicating the cytoprotective role of autophagy in Ru1-treated A549 and NCI-H460 cells.	3-methyladenine	79-83	Scm like with four mbt domains 1	Homo sapiens	189-192
26895770-13	2016	EA+3-MA treated rats had much higher TUNEL-positive neurons, lower LC3II/LC3I ratios and Beclin-1 expression, and elevated Abeta levels compared with EA alone.	3-methyladenine	3-7	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	67-77
26895770-13	2016	EA+3-MA treated rats had much higher TUNEL-positive neurons, lower LC3II/LC3I ratios and Beclin-1 expression, and elevated Abeta levels compared with EA alone.	3-methyladenine	3-7	beclin 1	Rattus norvegicus	89-97
26895770-13	2016	EA+3-MA treated rats had much higher TUNEL-positive neurons, lower LC3II/LC3I ratios and Beclin-1 expression, and elevated Abeta levels compared with EA alone.	3-methyladenine	3-7	amyloid beta precursor protein	Rattus norvegicus	123-128
27785603-9	2016	Linc-ROR siRNA showed similar effect as 3-MA on enhancing gemcitabine-induced cell apoptosis and also reduced PKM2 expression.	3-methyladenine	40-44	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	0-8
27785603-9	2016	Linc-ROR siRNA showed similar effect as 3-MA on enhancing gemcitabine-induced cell apoptosis and also reduced PKM2 expression.	3-methyladenine	40-44	pyruvate kinase M1/2	Homo sapiens	110-114
27906187-0	2016	Systemic application of 3-methyladenine markedly inhibited atherosclerotic lesion in ApoE-/- mice by modulating autophagy, foam cell formation and immune-negative molecules.	3-methyladenine	24-39	apolipoprotein E	Mus musculus	85-89
27259688-10	2016	RESULTS: Under chemical hypoxia conditions, Beclin-1 and LC3 levels increased and this change can be inhibited by 3-MA.	3-methyladenine	114-118	beclin 1	Macaca mulatta	44-52
27779641-6	2016	Furthermore, pretreatment with the autophagy inhibitor chloroquine or 3-methyladenine showed the potential in attenuating the apoptosis rate induced by Sal B. Mechanistically, Sal B treatment inhibited the AKT/mTOR signaling cascade in vitro.	3-methyladenine	70-85	AKT serine/threonine kinase 1	Homo sapiens	206-209
27779641-6	2016	Furthermore, pretreatment with the autophagy inhibitor chloroquine or 3-methyladenine showed the potential in attenuating the apoptosis rate induced by Sal B. Mechanistically, Sal B treatment inhibited the AKT/mTOR signaling cascade in vitro.	3-methyladenine	70-85	mechanistic target of rapamycin kinase	Homo sapiens	210-214
27659442-6	2016	An autophagy inhibitor, 3-methyladenine (3-MA) pretreatment significantly attenuated the increase of LC3II and the loss of P62/SQSTM1 and p-CREB, ameliorated neuronal death, and improved the results of Morris water maze.	3-methyladenine	24-39	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	123-126
27659442-6	2016	An autophagy inhibitor, 3-methyladenine (3-MA) pretreatment significantly attenuated the increase of LC3II and the loss of P62/SQSTM1 and p-CREB, ameliorated neuronal death, and improved the results of Morris water maze.	3-methyladenine	24-39	sequestosome 1	Rattus norvegicus	127-133
27659442-6	2016	An autophagy inhibitor, 3-methyladenine (3-MA) pretreatment significantly attenuated the increase of LC3II and the loss of P62/SQSTM1 and p-CREB, ameliorated neuronal death, and improved the results of Morris water maze.	3-methyladenine	41-45	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	123-126
27659442-6	2016	An autophagy inhibitor, 3-methyladenine (3-MA) pretreatment significantly attenuated the increase of LC3II and the loss of P62/SQSTM1 and p-CREB, ameliorated neuronal death, and improved the results of Morris water maze.	3-methyladenine	41-45	sequestosome 1	Rattus norvegicus	127-133
27721115-7	2016	Conversely, the neuronal cell injury, autophagosome accumulation and the effects of LC3 and Beclin1 overexpression caused by FA deficiency were partially blocked by an autophagic inhibitor 3-methyladenine.	3-methyladenine	189-204	annexin A3	Rattus norvegicus	84-87
27721115-7	2016	Conversely, the neuronal cell injury, autophagosome accumulation and the effects of LC3 and Beclin1 overexpression caused by FA deficiency were partially blocked by an autophagic inhibitor 3-methyladenine.	3-methyladenine	189-204	beclin 1	Rattus norvegicus	92-99
27604425-11	2016	Furthermore, the inhibition of autophagy by 3-MA further increased the expression of activated caspase 3, Bax, BNIP3, and BNIP3L, all are critical apoptotic mediators.	3-methyladenine	44-48	caspase 3	Homo sapiens	95-104
27604425-11	2016	Furthermore, the inhibition of autophagy by 3-MA further increased the expression of activated caspase 3, Bax, BNIP3, and BNIP3L, all are critical apoptotic mediators.	3-methyladenine	44-48	BCL2 associated X, apoptosis regulator	Homo sapiens	106-109
27604425-11	2016	Furthermore, the inhibition of autophagy by 3-MA further increased the expression of activated caspase 3, Bax, BNIP3, and BNIP3L, all are critical apoptotic mediators.	3-methyladenine	44-48	BCL2 interacting protein 3	Homo sapiens	111-116
27604425-11	2016	Furthermore, the inhibition of autophagy by 3-MA further increased the expression of activated caspase 3, Bax, BNIP3, and BNIP3L, all are critical apoptotic mediators.	3-methyladenine	44-48	BCL2 interacting protein 3 like	Homo sapiens	122-128
27568838-6	2016	Pretreatment with 3-MA reduced the expression of autophagy-related genes, autophagy and UPS co-related genes, as well as apoptosis-related although the latter was increased by Rap pretreatment at 2h, 4h and 6h following H/R treatment.	3-methyladenine	18-22	LDL receptor related protein associated protein 1	Rattus norvegicus	176-179
26961672-9	2016	Inhibition of autophagy by 3-methyladenine (3-MA) stimulated IL-1beta secretion in cells from both breeds, but was more pronounced in HF MO.	3-methyladenine	27-42	interleukin 1 beta	Bos taurus	61-69
26961672-9	2016	Inhibition of autophagy by 3-methyladenine (3-MA) stimulated IL-1beta secretion in cells from both breeds, but was more pronounced in HF MO.	3-methyladenine	44-48	interleukin 1 beta	Bos taurus	61-69
27827955-5	2016	Furthermore, Dkk-3 knock-down caused macropinocytosis accompanied by autophagy, which were canceled in part by their inhibitors 5-(N-ethyl-N-isopropyl) amiloride (EIPA) and 3-methyladenine (3-MA).	3-methyladenine	173-188	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	13-18
27827955-5	2016	Furthermore, Dkk-3 knock-down caused macropinocytosis accompanied by autophagy, which were canceled in part by their inhibitors 5-(N-ethyl-N-isopropyl) amiloride (EIPA) and 3-methyladenine (3-MA).	3-methyladenine	190-194	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	13-18
27769241-8	2016	And inhibition of autophagy by specific autophagosome inhibitor, 3-MA, reverses the effect of berberine on reducing the accumulation of insoluble TDP-43 and aggregates formation.	3-methyladenine	65-69	TAR DNA binding protein	Homo sapiens	146-152
27743378-4	2016	To gain the mechanistic insights, firstly, in the presence of 3-methyladenine (3MA), an autophagy inhibitor, we found that the reduction of CHK1 and the inhibition of cell growth in RAD51-deficient EC109 cells were strikingly restored.	3-methyladenine	62-77	checkpoint kinase 1	Homo sapiens	140-144
27743378-4	2016	To gain the mechanistic insights, firstly, in the presence of 3-methyladenine (3MA), an autophagy inhibitor, we found that the reduction of CHK1 and the inhibition of cell growth in RAD51-deficient EC109 cells were strikingly restored.	3-methyladenine	62-77	RAD51 recombinase	Homo sapiens	182-187
27743378-4	2016	To gain the mechanistic insights, firstly, in the presence of 3-methyladenine (3MA), an autophagy inhibitor, we found that the reduction of CHK1 and the inhibition of cell growth in RAD51-deficient EC109 cells were strikingly restored.	3-methyladenine	79-82	checkpoint kinase 1	Homo sapiens	140-144
27743378-4	2016	To gain the mechanistic insights, firstly, in the presence of 3-methyladenine (3MA), an autophagy inhibitor, we found that the reduction of CHK1 and the inhibition of cell growth in RAD51-deficient EC109 cells were strikingly restored.	3-methyladenine	79-82	RAD51 recombinase	Homo sapiens	182-187
27735867-6	2016	An increase in LC3-II levels was also observed, which was reverted by 3-methyladenine (3-MA) (an early stage autophagy-inhibitor) but further increased by E-64d/pepstatin (late-stage autophagy inhibitors).	3-methyladenine	70-85	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	15-18
27735867-6	2016	An increase in LC3-II levels was also observed, which was reverted by 3-methyladenine (3-MA) (an early stage autophagy-inhibitor) but further increased by E-64d/pepstatin (late-stage autophagy inhibitors).	3-methyladenine	87-91	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	15-18
27581524-6	2016	While deep hypothermia increased the LC3II/LC3I and Beclin 1, an autophagy marker, which can be inhibited by 3-methyladenine (3-MA), indicating that deep hypothermia-enhanced autophagy ameliorated apoptotic cell death in PC12 cells subjected to OGD.	3-methyladenine	109-124	beclin 1	Rattus norvegicus	52-60
27581524-6	2016	While deep hypothermia increased the LC3II/LC3I and Beclin 1, an autophagy marker, which can be inhibited by 3-methyladenine (3-MA), indicating that deep hypothermia-enhanced autophagy ameliorated apoptotic cell death in PC12 cells subjected to OGD.	3-methyladenine	126-130	beclin 1	Rattus norvegicus	52-60
27514525-7	2016	Further studies demonstrated that after pretreatment with 3-MA (3 mmol/L) for 48 h, siKDM4A-transfected cells showed a prominent decrease in LC3B-II/LC3B-I and Beclin 1, accompanied by increased viability and invasion and decreased apoptosis.	3-methyladenine	58-62	microtubule associated protein 1 light chain 3 beta	Homo sapiens	141-145
27514525-7	2016	Further studies demonstrated that after pretreatment with 3-MA (3 mmol/L) for 48 h, siKDM4A-transfected cells showed a prominent decrease in LC3B-II/LC3B-I and Beclin 1, accompanied by increased viability and invasion and decreased apoptosis.	3-methyladenine	58-62	microtubule associated protein 1 light chain 3 beta	Homo sapiens	149-153
27514525-7	2016	Further studies demonstrated that after pretreatment with 3-MA (3 mmol/L) for 48 h, siKDM4A-transfected cells showed a prominent decrease in LC3B-II/LC3B-I and Beclin 1, accompanied by increased viability and invasion and decreased apoptosis.	3-methyladenine	58-62	beclin 1	Homo sapiens	160-168
27586274-4	2016	The autophagy inhibitors 3-methyladenine and LY294002 enhanced MiTMAB-induced apoptotic sub-G1 peak, BAG3 and Mcl-1 down-regulation, Bak activation, Deltapsim loss, and caspase activation.	3-methyladenine	25-40	BAG cochaperone 3	Homo sapiens	101-105
27586274-4	2016	The autophagy inhibitors 3-methyladenine and LY294002 enhanced MiTMAB-induced apoptotic sub-G1 peak, BAG3 and Mcl-1 down-regulation, Bak activation, Deltapsim loss, and caspase activation.	3-methyladenine	25-40	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	110-115
27613096-9	2016	Finally, 3-methyladenine (3-MA)-induced inhibition of autophagy was found to reverse the sensitivity of hHR23A-knockdown cells to the tested DNA-damaging agents.	3-methyladenine	9-24	RAD23 homolog A, nucleotide excision repair protein	Homo sapiens	104-110
27613096-9	2016	Finally, 3-methyladenine (3-MA)-induced inhibition of autophagy was found to reverse the sensitivity of hHR23A-knockdown cells to the tested DNA-damaging agents.	3-methyladenine	26-30	RAD23 homolog A, nucleotide excision repair protein	Homo sapiens	104-110
27658240-6	2016	The nuclear translocation of endoG was minimal at a low concentration of safingol, but markedly increased when combined with 3-MA.	3-methyladenine	125-129	endonuclease G	Homo sapiens	29-34
27658240-7	2016	The suppressive effects of safingol and 3-MA on cell viability were reduced in endoG siRNA- transfected cells.	3-methyladenine	40-44	endonuclease G	Homo sapiens	79-84
27506738-7	2016	More interestingly, the glucose uptake and the phosphorylation of the insulin receptor were decreased by 3-MA stimulation and increased by rapamycin, illustrating that the responsiveness of insulin was regulated by autophagy.	3-methyladenine	105-109	insulin receptor	Homo sapiens	70-86
27506738-7	2016	More interestingly, the glucose uptake and the phosphorylation of the insulin receptor were decreased by 3-MA stimulation and increased by rapamycin, illustrating that the responsiveness of insulin was regulated by autophagy.	3-methyladenine	105-109	insulin	Homo sapiens	70-77
27413105-3	2016	The autophagosome formation inhibitor 3-methyladenine (3-MA) was able to relieve PFOS-induced LMP and release of cathepsin D in HepG2 cells.	3-methyladenine	38-53	cathepsin D	Homo sapiens	113-124
27413105-3	2016	The autophagosome formation inhibitor 3-methyladenine (3-MA) was able to relieve PFOS-induced LMP and release of cathepsin D in HepG2 cells.	3-methyladenine	55-59	cathepsin D	Homo sapiens	113-124
27413105-7	2016	Addition of 3-MA relieved PFOS-induced apoptosis, which was evidenced by Hoechst assay, AV/PI staining and caspase-3 activity assay.	3-methyladenine	12-16	caspase 3	Homo sapiens	107-116
27220268-9	2016	Moreover, cardiomyocytes pretreated with 3-methyladenine conferred resistance to the cytoprotective effect of miR-19a and displayed notably increased TUNEL staining and caspase-3 activity.	3-methyladenine	41-56	microRNA 19a	Homo sapiens	110-117
27220268-9	2016	Moreover, cardiomyocytes pretreated with 3-methyladenine conferred resistance to the cytoprotective effect of miR-19a and displayed notably increased TUNEL staining and caspase-3 activity.	3-methyladenine	41-56	caspase 3	Homo sapiens	169-178
29442034-10	2016	Phosphorylation levels of Raf-1 and ERK1/2 were increased in PC12 cells treated with 6-OHDA and inhibited by co-treatment with 6-OHDA and 3-MA.	3-methyladenine	138-142	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	26-31
29442034-10	2016	Phosphorylation levels of Raf-1 and ERK1/2 were increased in PC12 cells treated with 6-OHDA and inhibited by co-treatment with 6-OHDA and 3-MA.	3-methyladenine	138-142	mitogen activated protein kinase 3	Rattus norvegicus	36-42
27473161-4	2016	Autophagy in THP-1 macrophage FCs and in apoE-/- mice was regulated by Rapamycin (80 ug/mL) or 3-MA (10 mM).	3-methyladenine	95-99	apolipoprotein E	Mus musculus	41-45
27455253-10	2016	Conversely, LC3B and Beclin-1 overexpression and autophagosome accumulation caused by Hcy were partially blocked by the autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	140-155	beclin 1	Rattus norvegicus	21-29
27455253-10	2016	Conversely, LC3B and Beclin-1 overexpression and autophagosome accumulation caused by Hcy were partially blocked by the autophagy inhibitor 3-methyladenine (3-MA).	3-methyladenine	157-161	beclin 1	Rattus norvegicus	21-29
27391105-14	2016	Following treatment with 3-MA, the sensitivity of Atg3-overexpressing cells to bortezomib treatment was reduced.	3-methyladenine	25-29	autophagy related 3	Homo sapiens	50-54
27163719-7	2016	Moreover, the lost cell polarity labeled by F-actin and the absenced beta-catenin in RAPA-treated and 3-MA-treated cell membrane implied intracellular cytoskeleton alteration was induced by the activation and depression of autophagy.	3-methyladenine	102-106	catenin beta 1	Gallus gallus	69-81
27261572-11	2016	CSPCs also induced the expression of Bad, Bax and Beclin-1 proteins and decreased the expression of Bcl-2, which was inhibited by 3-MA and Z-VAD.	3-methyladenine	130-134	BCL2 apoptosis regulator	Homo sapiens	100-105
27177845-4	2016	Inhibition of autophagy by 3-methyladenine or siRNA knockdown of Beclin 1 reduced TGF-beta1-induced increase of vimentin and decreased E-cadherin expression.	3-methyladenine	27-42	transforming growth factor, beta 1	Mus musculus	82-91
25902863-5	2016	More importantly, inhibition of autophagy by 3-methyladenine markedly attenuated the apoptosis caused by Ang II in CATH.a cells.	3-methyladenine	45-60	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	105-111
27138352-7	2016	In contrast, podocytes treated with 3-methyladenine (3-MA), a potent autophagy inhibitor, had increased VEGF expression.	3-methyladenine	36-51	vascular endothelial growth factor A	Mus musculus	104-108
27138352-7	2016	In contrast, podocytes treated with 3-methyladenine (3-MA), a potent autophagy inhibitor, had increased VEGF expression.	3-methyladenine	53-57	vascular endothelial growth factor A	Mus musculus	104-108
27338051-10	2016	In addition, 3-MA also partly reversed the effect of GAS5 knockdown.	3-methyladenine	13-17	growth arrest specific 5	Homo sapiens	53-57
27338051-11	2016	In A549/DDP cells, GAS5 showed the similar effect as 3-MA in reducing DPP IC50 and promoting DDP-induced apoptosis and also presented synergic effect with 3-MA.	3-methyladenine	53-57	growth arrest specific 5	Homo sapiens	19-23
27338051-11	2016	In A549/DDP cells, GAS5 showed the similar effect as 3-MA in reducing DPP IC50 and promoting DDP-induced apoptosis and also presented synergic effect with 3-MA.	3-methyladenine	155-159	growth arrest specific 5	Homo sapiens	19-23
26964766-11	2016	Simultaneously, both in vivo and in vitro, 3-MA significantly decreased the expression of LC3-II and Beclin-1, and maintained p62 at high level after ICH.	3-methyladenine	43-47	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	90-93
26964766-11	2016	Simultaneously, both in vivo and in vitro, 3-MA significantly decreased the expression of LC3-II and Beclin-1, and maintained p62 at high level after ICH.	3-methyladenine	43-47	beclin 1, autophagy related	Mus musculus	101-109
26964766-11	2016	Simultaneously, both in vivo and in vitro, 3-MA significantly decreased the expression of LC3-II and Beclin-1, and maintained p62 at high level after ICH.	3-methyladenine	43-47	sequestosome 1	Mus musculus	126-129
26964766-12	2016	Furthermore, pretreatment with 3-MA downregulated the level of cleaved caspase-3 but upregulated the Bcl-2 level.	3-methyladenine	31-35	B cell leukemia/lymphoma 2	Mus musculus	101-106
27109777-9	2016	However, inhibition of autophagy by 3-MA reduced the radiation-induced upregulation of LC3-II and DRAM.	3-methyladenine	36-40	DNA damage regulated autophagy modulator 1	Homo sapiens	98-102
30090427-6	2016	Verified by the autophagy inhibitor 3-MA, the expression of LC3 and SQSTM1/p62 was upregulated in nano-scale silica particles in a size- and dose-dependent manner, while the micro-scale particles had an inhibitory effect.	3-methyladenine	36-40	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	60-63
30090427-6	2016	Verified by the autophagy inhibitor 3-MA, the expression of LC3 and SQSTM1/p62 was upregulated in nano-scale silica particles in a size- and dose-dependent manner, while the micro-scale particles had an inhibitory effect.	3-methyladenine	36-40	sequestosome 1	Homo sapiens	68-74
30090427-6	2016	Verified by the autophagy inhibitor 3-MA, the expression of LC3 and SQSTM1/p62 was upregulated in nano-scale silica particles in a size- and dose-dependent manner, while the micro-scale particles had an inhibitory effect.	3-methyladenine	36-40	sequestosome 1	Homo sapiens	75-78
27398310-7	2016	Knockdown of DCN expression or the disruption of autophagy with 3-methyladenine (3-MA) was able to reduce the suppression on cell adhesion and migration induced by DCN.	3-methyladenine	64-79	decorin	Homo sapiens	164-167
27398310-7	2016	Knockdown of DCN expression or the disruption of autophagy with 3-methyladenine (3-MA) was able to reduce the suppression on cell adhesion and migration induced by DCN.	3-methyladenine	81-85	decorin	Homo sapiens	164-167
26971628-7	2016	The long non-coding RNA PVT1 (plasmacytoma variant translocation 1) expression was analyzed, and data revealed that PVT1 was decreased significantly by 3-MA in diabetes.	3-methyladenine	152-156	Pvt1 oncogene	Mus musculus	24-28
26971628-7	2016	The long non-coding RNA PVT1 (plasmacytoma variant translocation 1) expression was analyzed, and data revealed that PVT1 was decreased significantly by 3-MA in diabetes.	3-methyladenine	152-156	Pvt1 oncogene	Mus musculus	30-66
26971628-7	2016	The long non-coding RNA PVT1 (plasmacytoma variant translocation 1) expression was analyzed, and data revealed that PVT1 was decreased significantly by 3-MA in diabetes.	3-methyladenine	152-156	Pvt1 oncogene	Mus musculus	116-120
27190722-5	2016	The Bcl-xL inhibitor Z36 induced death in primary cells from ATL patients including that induced by CuD treatment, effects that were partly inhibited by 3-MA.	3-methyladenine	153-157	BCL2 like 1	Homo sapiens	4-10
27136357-11	2016	Autophagy inhibition by 3-methyladenine significantly reduced apoptosis and ameliorated cardiac dysfunction following MI in Akap1-/- mice.	3-methyladenine	24-39	A kinase (PRKA) anchor protein 1	Mus musculus	124-129
27041458-11	2016	Moreover, sevoflurane-stimulated expression of CHOP and GRP78 was inhibited by rapamycin, but further enhanced by 3-MA.	3-methyladenine	114-118	DNA damage inducible transcript 3	Homo sapiens	47-51
27041458-11	2016	Moreover, sevoflurane-stimulated expression of CHOP and GRP78 was inhibited by rapamycin, but further enhanced by 3-MA.	3-methyladenine	114-118	heat shock protein family A (Hsp70) member 5	Homo sapiens	56-61
26996127-5	2016	The autophagy inhibitor 3-MA (3-methyladenine) could dramatically reduce TiPs-induced TNF-alpha expression both in macrophages and in membranes from animal models.	3-methyladenine	24-28	tumor necrosis factor	Homo sapiens	86-95
26996127-5	2016	The autophagy inhibitor 3-MA (3-methyladenine) could dramatically reduce TiPs-induced TNF-alpha expression both in macrophages and in membranes from animal models.	3-methyladenine	30-45	tumor necrosis factor	Homo sapiens	86-95
26934124-9	2016	When autophagy was inhibited by 3-methyladenine, KYSE180 cells exhibited an increased sensitivity to EDHB, which may be a metabolic substrate of AKR1C1/C2.	3-methyladenine	32-47	aldo-keto reductase family 1 member C1	Homo sapiens	145-151
26923671-5	2016	The effects of Beclin-1 dependent autophagy that were activated by a gradient concentration of autophagy activator rapamycin or inhibited by autophagy inhibitor 3-methyladenine (3-MA) on cell viability and cell morphology were examined.	3-methyladenine	178-182	beclin 1	Rattus norvegicus	15-23
26923671-6	2016	Pretreatment with rapamycin significantly up-regulated the expression of Beclin-1 in response to Abeta1-42 application, but after pretreatment with 3-MA it was significantly down-regulated.	3-methyladenine	148-152	beclin 1	Rattus norvegicus	73-81
27052304-2	2016	METHODS: In this study, a cellular OA model was generated by stimulating SW1353 cells with IL-1beta and a rabbit OA model was established by intra-articular injection of collagenase, followed by treatment with Torin 1 or 3-Methyladenine (3-MA).	3-methyladenine	221-236	peroxiredoxin 2	Homo sapiens	210-215
27052304-2	2016	METHODS: In this study, a cellular OA model was generated by stimulating SW1353 cells with IL-1beta and a rabbit OA model was established by intra-articular injection of collagenase, followed by treatment with Torin 1 or 3-Methyladenine (3-MA).	3-methyladenine	238-242	peroxiredoxin 2	Homo sapiens	210-215
26882903-12	2016	ShRNA-Gadd45b co-treatment with autophagy inhibitor 3-methyladenine (3-MA) or Wortmannin partly inhibited the ratio of LC3II/LC3I, and slightly ameliorated neuron cell apoptosis under OGD/R.	3-methyladenine	52-67	growth arrest and DNA-damage-inducible, beta	Rattus norvegicus	6-13
26882903-12	2016	ShRNA-Gadd45b co-treatment with autophagy inhibitor 3-methyladenine (3-MA) or Wortmannin partly inhibited the ratio of LC3II/LC3I, and slightly ameliorated neuron cell apoptosis under OGD/R.	3-methyladenine	69-73	growth arrest and DNA-damage-inducible, beta	Rattus norvegicus	6-13
26721623-8	2016	This was also observed with the organelle-specific variants Bcl-xL-ActA and Bcl-2-ActA (mitochondrial) as well as Bcl-xL-cb5 and Bcl-2-cb5 (ER) which all reduced AT-101-induced cell death, but did not affect the death-enhancing effects of 3-MA.	3-methyladenine	239-243	BCL2 like 1	Homo sapiens	60-66
26721623-8	2016	This was also observed with the organelle-specific variants Bcl-xL-ActA and Bcl-2-ActA (mitochondrial) as well as Bcl-xL-cb5 and Bcl-2-cb5 (ER) which all reduced AT-101-induced cell death, but did not affect the death-enhancing effects of 3-MA.	3-methyladenine	239-243	BCL2 apoptosis regulator	Homo sapiens	76-81
26721623-8	2016	This was also observed with the organelle-specific variants Bcl-xL-ActA and Bcl-2-ActA (mitochondrial) as well as Bcl-xL-cb5 and Bcl-2-cb5 (ER) which all reduced AT-101-induced cell death, but did not affect the death-enhancing effects of 3-MA.	3-methyladenine	239-243	BCL2 like 1	Homo sapiens	114-120
26721623-8	2016	This was also observed with the organelle-specific variants Bcl-xL-ActA and Bcl-2-ActA (mitochondrial) as well as Bcl-xL-cb5 and Bcl-2-cb5 (ER) which all reduced AT-101-induced cell death, but did not affect the death-enhancing effects of 3-MA.	3-methyladenine	239-243	BCL2 apoptosis regulator	Homo sapiens	129-134
27358149-4	2016	Both rapamycin and 3-MA inhibited CyclinD1 (CCND1) and CyclinD2 (CCND2) expression.	3-methyladenine	19-23	cyclin D1	Mus musculus	34-42
27358149-4	2016	Both rapamycin and 3-MA inhibited CyclinD1 (CCND1) and CyclinD2 (CCND2) expression.	3-methyladenine	19-23	cyclin D1	Mus musculus	44-49
27358149-4	2016	Both rapamycin and 3-MA inhibited CyclinD1 (CCND1) and CyclinD2 (CCND2) expression.	3-methyladenine	19-23	cyclin D2	Mus musculus	55-63
27358149-4	2016	Both rapamycin and 3-MA inhibited CyclinD1 (CCND1) and CyclinD2 (CCND2) expression.	3-methyladenine	19-23	cyclin D2	Mus musculus	65-70
26913856-6	2016	The autophagy inhibitor 3-methyladenine (3-MA) suppressed the growth of leukemia cell lines HuT78, Jurkat, MT-1, and MT-4.	3-methyladenine	24-39	metallothionein 1I, pseudogene	Homo sapiens	107-111
26913856-6	2016	The autophagy inhibitor 3-methyladenine (3-MA) suppressed the growth of leukemia cell lines HuT78, Jurkat, MT-1, and MT-4.	3-methyladenine	24-39	metallothionein 4	Homo sapiens	117-121
26913856-6	2016	The autophagy inhibitor 3-methyladenine (3-MA) suppressed the growth of leukemia cell lines HuT78, Jurkat, MT-1, and MT-4.	3-methyladenine	41-45	metallothionein 1I, pseudogene	Homo sapiens	107-111
26913856-6	2016	The autophagy inhibitor 3-methyladenine (3-MA) suppressed the growth of leukemia cell lines HuT78, Jurkat, MT-1, and MT-4.	3-methyladenine	41-45	metallothionein 4	Homo sapiens	117-121
26335692-9	2016	In addition, treatment with Bafilomycin A1 (Baf) and 3-methyladenine (3-MA), the inhibitors of autophagy, further increased the cell death in 2-ME-treated chondrosarcoma cells.	3-methyladenine	70-74	BAF nuclear assembly factor 1	Homo sapiens	28-31
26487273-6	2016	The small-interfering RNA knockdown of Atg7, and treatment with 3-methyladenine, restores bort sensitivity in bort-resistant CAFs and produces cytotoxicity in plasma cells co-cultured with CAFs.	3-methyladenine	64-79	T-box transcription factor 1	Homo sapiens	125-129
26487273-6	2016	The small-interfering RNA knockdown of Atg7, and treatment with 3-methyladenine, restores bort sensitivity in bort-resistant CAFs and produces cytotoxicity in plasma cells co-cultured with CAFs.	3-methyladenine	64-79	T-box transcription factor 1	Homo sapiens	189-193
26847932-7	2016	The MIF anti-apoptotic effects were blocked by autophagy inhibitor, 3-methyladenine or AMPK inhibitor, Compound C. These results indicate that MIF exerts a permissive role in protecting MSCs from apoptosis by regulation of autophagy via the AMPK/mTOR signaling pathway.	3-methyladenine	68-83	macrophage migration inhibitory factor	Homo sapiens	4-7
26847932-7	2016	The MIF anti-apoptotic effects were blocked by autophagy inhibitor, 3-methyladenine or AMPK inhibitor, Compound C. These results indicate that MIF exerts a permissive role in protecting MSCs from apoptosis by regulation of autophagy via the AMPK/mTOR signaling pathway.	3-methyladenine	68-83	macrophage migration inhibitory factor	Homo sapiens	143-146
26676298-9	2016	Moreover, the inhibition of autophagy by 3-methyladenine or Atg5 siRNA significantly enhanced ramalin-induced apoptosis, which was accompanied by a decrease in Bcl-2 levels and an increase in Bax levels.	3-methyladenine	41-56	BCL2 apoptosis regulator	Homo sapiens	160-165
26676298-9	2016	Moreover, the inhibition of autophagy by 3-methyladenine or Atg5 siRNA significantly enhanced ramalin-induced apoptosis, which was accompanied by a decrease in Bcl-2 levels and an increase in Bax levels.	3-methyladenine	41-56	BCL2 associated X, apoptosis regulator	Homo sapiens	192-195
26923134-13	2016	Furthermore, treatment with an autophagy inhibitor, 3-MA, enhanced RBM5-induced cell death and chemosensitivity in A549 cells.	3-methyladenine	52-56	RNA binding motif protein 5	Homo sapiens	67-71
26797274-3	2016	Meanwhile, autophagy repression with 3-methyladenine accelerated the activation of caspase-3 and PARP and aggravated the cell apoptotic death induced by 6-OHDA.	3-methyladenine	37-52	caspase 3	Homo sapiens	83-92
26797274-3	2016	Meanwhile, autophagy repression with 3-methyladenine accelerated the activation of caspase-3 and PARP and aggravated the cell apoptotic death induced by 6-OHDA.	3-methyladenine	37-52	collagen type XI alpha 2 chain	Homo sapiens	97-101
26804764-10	2016	Moreover, The activation of AMPK/mTOR/p70s6k/4EBP1 and JNK signalling pathways induced by NP could be efficiently reversed by pretreatment of N-acetylcysteine or 3-MA.	3-methyladenine	162-166	mechanistic target of rapamycin kinase	Rattus norvegicus	33-37
26804764-10	2016	Moreover, The activation of AMPK/mTOR/p70s6k/4EBP1 and JNK signalling pathways induced by NP could be efficiently reversed by pretreatment of N-acetylcysteine or 3-MA.	3-methyladenine	162-166	ribosomal protein S6 kinase B1	Rattus norvegicus	38-50
26804764-10	2016	Moreover, The activation of AMPK/mTOR/p70s6k/4EBP1 and JNK signalling pathways induced by NP could be efficiently reversed by pretreatment of N-acetylcysteine or 3-MA.	3-methyladenine	162-166	mitogen-activated protein kinase 8	Rattus norvegicus	55-58
26676567-8	2016	When autophagy was inhibited by 3-MA or chloroquine, the percentage of apoptotic cells and NSE-positive cells as well as the expression of MAP2 were markedly reduced compared to those in the control group (P&lt;0.05).	3-methyladenine	32-36	enolase 2	Rattus norvegicus	91-94
26676567-8	2016	When autophagy was inhibited by 3-MA or chloroquine, the percentage of apoptotic cells and NSE-positive cells as well as the expression of MAP2 were markedly reduced compared to those in the control group (P&lt;0.05).	3-methyladenine	32-36	microtubule-associated protein 2	Rattus norvegicus	139-143
26677174-5	2016	The autophagy inhibitors 3-methyladenine and NH4Cl abolished the protective effects of TK.	3-methyladenine	25-40	kallikrein 1	Homo sapiens	87-89
26663083-7	2016	Blocking autophagy by treating cells with 3-methyladenine or overexpressing dominant-negative ATG5 abolished the deficiency of the p38alpha MAPK-induced BACE1 protein reduction in cultured cells.	3-methyladenine	42-57	mitogen-activated protein kinase 14	Mus musculus	131-139
26663083-7	2016	Blocking autophagy by treating cells with 3-methyladenine or overexpressing dominant-negative ATG5 abolished the deficiency of the p38alpha MAPK-induced BACE1 protein reduction in cultured cells.	3-methyladenine	42-57	beta-site APP cleaving enzyme 1	Mus musculus	153-158
26778963-7	2015	However, the BACE1 RNAi-mediated reduction of hyperphosphorylated tau was only blocked by 3-MA (3-methyladenine) in vitro, and it resulted in the increase of Hsc70 and LAMP2 in lipid rafts from hippocampi of 3xTg-AD mice, and upregulation of survival and homeostasis signaling.	3-methyladenine	90-94	beta-site APP cleaving enzyme 1	Mus musculus	13-18
26778963-7	2015	However, the BACE1 RNAi-mediated reduction of hyperphosphorylated tau was only blocked by 3-MA (3-methyladenine) in vitro, and it resulted in the increase of Hsc70 and LAMP2 in lipid rafts from hippocampi of 3xTg-AD mice, and upregulation of survival and homeostasis signaling.	3-methyladenine	96-111	beta-site APP cleaving enzyme 1	Mus musculus	13-18
27383426-10	2016	In addition, the autophagy inhibitor 3-MA partly impeded the inhibitory effect of BAG3 on hypoxia-induced cardiomyocyte apoptosis.	3-methyladenine	37-41	BAG cochaperone 3	Rattus norvegicus	82-86
27866190-10	2016	Autophagy mediated the effects of MCPIP1, as rapamycin and 3-MA enhanced and attenuated the effect of SiO2 on HUVECs, respectively.	3-methyladenine	59-63	zinc finger CCCH-type containing 12A	Homo sapiens	34-40
26112695-13	2016	3-MA attenuated the increased expression of LC3-II and eosinophil cationic protein in HL-60 cells induced by IL-5 (P = 0.034 for both).	3-methyladenine	0-4	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	44-47
26112695-13	2016	3-MA attenuated the increased expression of LC3-II and eosinophil cationic protein in HL-60 cells induced by IL-5 (P = 0.034 for both).	3-methyladenine	0-4	interleukin 5	Homo sapiens	109-113
26534988-7	2016	Autophagy inhibitor 3-methyladenine accumulated YFP-hPXR T408D mutant more efficiently than the WT in the presence of proteasome inhibitor lactacystin, and the T408D mutant colocalized with the autophagy markers, microtubule-associated protein 1 light chain 3 and p62, which were contained in the autophagic cargo.	3-methyladenine	20-35	nuclear receptor subfamily 1 group I member 2	Homo sapiens	52-56
26534988-7	2016	Autophagy inhibitor 3-methyladenine accumulated YFP-hPXR T408D mutant more efficiently than the WT in the presence of proteasome inhibitor lactacystin, and the T408D mutant colocalized with the autophagy markers, microtubule-associated protein 1 light chain 3 and p62, which were contained in the autophagic cargo.	3-methyladenine	20-35	nucleoporin 62	Homo sapiens	264-267
26555754-6	2016	Inhibition of the autophagic process by pretreatment with 3-MA blocked blue LED irradiation-induced caspase-3 activation.	3-methyladenine	58-62	caspase 3	Homo sapiens	100-109
26549648-5	2016	Furthermore, blocking of autophagy by 3-MA exerted an inhibitory effect on imiquimod-induced apoptosis, which indicated that autophagy can function as a mechanism which, upon activation, directly leads to apoptosis and cell death of SGC-7901 cells.	3-methyladenine	38-42	sarcoglycan beta	Homo sapiens	233-236
26648440-7	2016	In addition, autophagic flux-inactivating reagents, including 3-methyladenine and chloroquine, increased the TRAIL sensitivity of HaCaT cells exposed to hypoxia.	3-methyladenine	62-77	TNF superfamily member 10	Homo sapiens	109-114
26610922-9	2016	In an in vivo animal model administered MDMA, neuroimaging showed that 3-MA protected the serotonin system against MDMA-induced downregulation of SERT evaluated by animal-PET with 4-[(18)F]-ADAM, a SERT radioligand.	3-methyladenine	71-75	solute carrier family 6 member 4	Rattus norvegicus	146-150
26610922-9	2016	In an in vivo animal model administered MDMA, neuroimaging showed that 3-MA protected the serotonin system against MDMA-induced downregulation of SERT evaluated by animal-PET with 4-[(18)F]-ADAM, a SERT radioligand.	3-methyladenine	71-75	solute carrier family 6 member 4	Rattus norvegicus	198-202
26943028-5	2016	Inhibiting MB-induced autophagy with the autophagy inhibitor 3-methyladenine (3-MA) significantly decreased apoptosis, with a reduction of growth inhibition; inhibiting MB-induced apoptosis with the pan-caspase inhibitor Z-VAD-FMK did not decrease autophagy but elevated LC3-II levels, indicating that MB-induced autophagy is cytotoxic and may be upstream of apoptosis.	3-methyladenine	61-76	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	271-274
26943028-5	2016	Inhibiting MB-induced autophagy with the autophagy inhibitor 3-methyladenine (3-MA) significantly decreased apoptosis, with a reduction of growth inhibition; inhibiting MB-induced apoptosis with the pan-caspase inhibitor Z-VAD-FMK did not decrease autophagy but elevated LC3-II levels, indicating that MB-induced autophagy is cytotoxic and may be upstream of apoptosis.	3-methyladenine	78-82	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	271-274
27703600-4	2016	CH prevented the increase in SA-beta-gal positive cells induced by RITA (reactivation of p53 and induction of tumor cell apoptosis, a p53 activator) or 3-MA (3-methyladenine, an autophagy inhibitor).	3-methyladenine	152-156	SH3 domain binding protein 5	Homo sapiens	29-36
27703600-4	2016	CH prevented the increase in SA-beta-gal positive cells induced by RITA (reactivation of p53 and induction of tumor cell apoptosis, a p53 activator) or 3-MA (3-methyladenine, an autophagy inhibitor).	3-methyladenine	158-173	SH3 domain binding protein 5	Homo sapiens	29-36
28058089-6	2016	Interestingly, pretreatment with 3-methyladenine (3-MA) resulted in the attenuation of CLOCK-induced cell autophagy and but did not influence the production of intracellular reactive oxygen species (ROS).	3-methyladenine	33-48	clock circadian regulator	Homo sapiens	87-92
28058089-6	2016	Interestingly, pretreatment with 3-methyladenine (3-MA) resulted in the attenuation of CLOCK-induced cell autophagy and but did not influence the production of intracellular reactive oxygen species (ROS).	3-methyladenine	50-54	clock circadian regulator	Homo sapiens	87-92
26260273-10	2016	Besides, interference of autophagy with 3-MA led to proliferation inhibition and increased apoptosis in HeLa cells, accompanied by the decreased LC3-I/II conversion and the increased active caspase-3.	3-methyladenine	40-44	caspase 3	Homo sapiens	190-199
26419929-7	2015	Compound C, an AMPK inhibitor, and 3 methyladenine (3 MA), an autophagy inhibitor, canceled the effects of CTRP9 on ER stress, apoptosis and hepatic steatosis.	3-methyladenine	35-50	C1q and TNF related 9	Homo sapiens	107-112
26522224-7	2015	Inhibition of autophagy with 3-MA enhanced the silibinin-induced apoptosis through the regulation of caspase-3 and PARP.	3-methyladenine	29-33	caspase 3	Homo sapiens	101-110
26522224-7	2015	Inhibition of autophagy with 3-MA enhanced the silibinin-induced apoptosis through the regulation of caspase-3 and PARP.	3-methyladenine	29-33	collagen type XI alpha 2 chain	Homo sapiens	115-119
26607438-10	2015	The autophagy inhibitor 3MA ameliorated the increase of cell diameter, volume, and protein content that were induced by apelin-13.	3-methyladenine	24-27	apelin	Rattus norvegicus	120-126
26524416-4	2015	Apoptosis as induced in mechanically injured neurons with G-CSF treatment was enhanced after inhibiting autophagy by 3-methyladenine (3-MA), which partially blocked the neuroprotective effect of autophagy as induced by G-CSF.	3-methyladenine	117-132	colony stimulating factor 3 (granulocyte)	Mus musculus	58-63
26524416-4	2015	Apoptosis as induced in mechanically injured neurons with G-CSF treatment was enhanced after inhibiting autophagy by 3-methyladenine (3-MA), which partially blocked the neuroprotective effect of autophagy as induced by G-CSF.	3-methyladenine	117-132	colony stimulating factor 3 (granulocyte)	Mus musculus	219-224
26524416-4	2015	Apoptosis as induced in mechanically injured neurons with G-CSF treatment was enhanced after inhibiting autophagy by 3-methyladenine (3-MA), which partially blocked the neuroprotective effect of autophagy as induced by G-CSF.	3-methyladenine	134-138	colony stimulating factor 3 (granulocyte)	Mus musculus	58-63
26524416-4	2015	Apoptosis as induced in mechanically injured neurons with G-CSF treatment was enhanced after inhibiting autophagy by 3-methyladenine (3-MA), which partially blocked the neuroprotective effect of autophagy as induced by G-CSF.	3-methyladenine	134-138	colony stimulating factor 3 (granulocyte)	Mus musculus	219-224
26398820-5	2015	The negative correlation with Bcl2 and survivin, and the chemotherapy drug 5-FU increased the level of autophagy and the autophagy inhibitor 3-MA inhibited this effect in SSCC cells, time- and dose-dependently.	3-methyladenine	141-145	BCL2 apoptosis regulator	Homo sapiens	30-34
26349538-5	2015	3-Methyladenine, an autophagy inhibitor, blocked the epoxomicin-induced decrease in WNK4.	3-methyladenine	0-15	WNK lysine deficient protein kinase 4	Homo sapiens	84-88
26491898-6	2015	By employing an embryonic bone culture system, we demonstrated that treatment with autophagy inhibitor 3-MA or chloroquine led to cartilage growth retardation, which mimics the effect of activated-FGFR3 signaling on chondrogenesis.	3-methyladenine	103-107	fibroblast growth factor receptor 3	Homo sapiens	197-202
26557017-8	2015	However, pretreatment with 3-methyladenine (3MA), the specific inhibitor for autophagy, decreased cell viability, whereas increased the cleavage of PARP and caspase-3 in the SNP-treated MC3T3-E1 cells.	3-methyladenine	27-42	poly (ADP-ribose) polymerase family, member 1	Mus musculus	148-152
26557017-8	2015	However, pretreatment with 3-methyladenine (3MA), the specific inhibitor for autophagy, decreased cell viability, whereas increased the cleavage of PARP and caspase-3 in the SNP-treated MC3T3-E1 cells.	3-methyladenine	27-42	caspase 3	Mus musculus	157-166
26557017-8	2015	However, pretreatment with 3-methyladenine (3MA), the specific inhibitor for autophagy, decreased cell viability, whereas increased the cleavage of PARP and caspase-3 in the SNP-treated MC3T3-E1 cells.	3-methyladenine	44-47	poly (ADP-ribose) polymerase family, member 1	Mus musculus	148-152
26557017-8	2015	However, pretreatment with 3-methyladenine (3MA), the specific inhibitor for autophagy, decreased cell viability, whereas increased the cleavage of PARP and caspase-3 in the SNP-treated MC3T3-E1 cells.	3-methyladenine	44-47	caspase 3	Mus musculus	157-166
26496360-11	2015	An autophagy inhibitor, methyladenine (3-MA) induced death and attenuated the level of elevated LC3 in MCF-7/TAM cells.	3-methyladenine	39-43	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	96-99
26501338-11	2015	The 3-MA treatment decreased levels of Beclin-1 and Atg 7 but increased levels of p62 in the ethanol-fed WT and KI mice whereas rapamycin had the opposite effects, validating inhibition and stimulation of autophagy, respectively.	3-methyladenine	4-8	beclin 1, autophagy related	Mus musculus	39-47
26501338-11	2015	The 3-MA treatment decreased levels of Beclin-1 and Atg 7 but increased levels of p62 in the ethanol-fed WT and KI mice whereas rapamycin had the opposite effects, validating inhibition and stimulation of autophagy, respectively.	3-methyladenine	4-8	autophagy related 7	Mus musculus	52-57
26501338-11	2015	The 3-MA treatment decreased levels of Beclin-1 and Atg 7 but increased levels of p62 in the ethanol-fed WT and KI mice whereas rapamycin had the opposite effects, validating inhibition and stimulation of autophagy, respectively.	3-methyladenine	4-8	nucleoporin 62	Mus musculus	82-85
26306675-6	2015	Atg5, Atg7 and Beclin-1 siRNA mediated genetic attenuation and pre-treatment with pharmacological inhibitor 3-MA and CQ diminished the autophagy and increased the propensity of cell death towards apoptosis.	3-methyladenine	108-112	autophagy related 5	Homo sapiens	0-4
26440217-8	2015	Inhibition of autophagy by 3-methyladenine (3-MA) dramatically resulted in decrease of polyhedrin expression and polyhedra particle production.	3-methyladenine	27-42	Polyhedrin	Bombyx mori nucleopolyhedrovirus	87-97
26440217-8	2015	Inhibition of autophagy by 3-methyladenine (3-MA) dramatically resulted in decrease of polyhedrin expression and polyhedra particle production.	3-methyladenine	44-48	Polyhedrin	Bombyx mori nucleopolyhedrovirus	87-97
26063592-5	2015	Because 3-methyladenine (an autophagic inhibitor) attenuated the arsenite-reduced alpha-synuclein levels (a protein essential for the neurite outgrowth and synaptic plasticity), melatonin via inhibiting autophagy attenuated the arsenite-reduced alpha-synuclein levels.	3-methyladenine	8-23	synuclein alpha	Rattus norvegicus	82-97
26397365-6	2015	The autophagy induced positively contributed to the inhibition of cell proliferation because the growth attenuation capacity of G9a inhibition was reversed by autophagy inhibitors 3-MA.	3-methyladenine	180-184	euchromatic histone lysine methyltransferase 2	Homo sapiens	128-131
26361755-0	2015	Inhibition of autophagy by 3-MA enhances IL-24-induced apoptosis in human oral squamous cell carcinoma cells.	3-methyladenine	27-31	interleukin 24	Homo sapiens	41-46
26361755-11	2015	IL-24 treated cells showed autophagy characteristics and autophagy inhibition by 3-methyladenine (3-MA) significantly enhanced IL-24-induced apoptosis.	3-methyladenine	81-96	interleukin 24	Homo sapiens	0-5
26361755-11	2015	IL-24 treated cells showed autophagy characteristics and autophagy inhibition by 3-methyladenine (3-MA) significantly enhanced IL-24-induced apoptosis.	3-methyladenine	81-96	interleukin 24	Homo sapiens	127-132
26361755-11	2015	IL-24 treated cells showed autophagy characteristics and autophagy inhibition by 3-methyladenine (3-MA) significantly enhanced IL-24-induced apoptosis.	3-methyladenine	98-102	interleukin 24	Homo sapiens	0-5
26361755-11	2015	IL-24 treated cells showed autophagy characteristics and autophagy inhibition by 3-methyladenine (3-MA) significantly enhanced IL-24-induced apoptosis.	3-methyladenine	98-102	interleukin 24	Homo sapiens	127-132
26163874-8	2015	The use of autophagy inhibitors, 3-methyladenine and bafilomycin A, identified that CREG attenuated TNF-alpha induced inflammation by activate autophagy.	3-methyladenine	33-48	tumor necrosis factor	Mus musculus	100-109
26604904-4	2015	Either oxygen-glucose deprivation or Rapamycin down-regulated the expression of BACE1 while 3-methyladenine up-regulated BACE1 expression.	3-methyladenine	92-107	beta-site APP cleaving enzyme 1	Mus musculus	121-126
26325184-10	2015	The neuroprotective effects of IPC on hippocampal CA1 neurons were completely inhibited by treatment with 3-MA.	3-methyladenine	106-110	carbonic anhydrase 1	Mus musculus	50-53
26363168-11	2015	Conversely, autophagy inhibition by 3-methyladenine enhanced COX-2 expression.	3-methyladenine	36-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
26102024-5	2015	3-methyladenine (3-MA) inhibited occurrence of autophagy and it leaded to the accumulation of damaged-mitochondria-producing-ROS, and the activation of NLRP3 inflammasome, and subsequently, caused IL-1beta secretion.	3-methyladenine	0-15	NLR family pyrin domain containing 3	Homo sapiens	152-157
26102024-5	2015	3-methyladenine (3-MA) inhibited occurrence of autophagy and it leaded to the accumulation of damaged-mitochondria-producing-ROS, and the activation of NLRP3 inflammasome, and subsequently, caused IL-1beta secretion.	3-methyladenine	0-15	interleukin 1 beta	Homo sapiens	197-205
26102024-5	2015	3-methyladenine (3-MA) inhibited occurrence of autophagy and it leaded to the accumulation of damaged-mitochondria-producing-ROS, and the activation of NLRP3 inflammasome, and subsequently, caused IL-1beta secretion.	3-methyladenine	17-21	NLR family pyrin domain containing 3	Homo sapiens	152-157
26102024-5	2015	3-methyladenine (3-MA) inhibited occurrence of autophagy and it leaded to the accumulation of damaged-mitochondria-producing-ROS, and the activation of NLRP3 inflammasome, and subsequently, caused IL-1beta secretion.	3-methyladenine	17-21	interleukin 1 beta	Homo sapiens	197-205
26244661-9	2015	Further, decreased cell viability induced by Abeta was prevented by cilostazol, and this inhibition was reversed by 3-methyladenine, indicating that the protective effect of cilostazol against Abeta induced neurotoxicity is, in part, ascribable to the induction of autophagy.	3-methyladenine	116-131	amyloid beta precursor protein	Homo sapiens	193-198
26043797-8	2015	Pretreatment with the autophagy inhibitors LY294002, 3-methyladenine, chloroquine, and bafilomycin A1 enhanced the induction of apoptosis by MHY218, and this was accompanied by an increase in PARP cleavage.	3-methyladenine	53-68	poly(ADP-ribose) polymerase 1	Homo sapiens	192-196
26283886-12	2015	Mice pretreated with 3-MA before exposure to LPS showed a reduction in p65 phosphorylation, resulting in the accumulation of ubiquitinated IkappaB.	3-methyladenine	21-25	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	71-74
25649430-6	2015	Furthermore, NS5ATP9-mediated autophagy is required for promotion of tumour cell growth, and this effect could be inhibited with 3-methyladenine, chloroquine or by Beclin 1-silencing.	3-methyladenine	129-144	PCNA clamp associated factor	Homo sapiens	13-20
25846607-8	2015	Inhibition of autophagy by 3-MA increased the expression levels of protein disulfide isomerase, ubiquitinated proteins, glucose regulated protein 78 and CCAAT-enhancer-binding protein homologous protein, and induced the activation of caspase-4 and caspase-3.	3-methyladenine	27-31	caspase 4	Homo sapiens	234-243
25846607-8	2015	Inhibition of autophagy by 3-MA increased the expression levels of protein disulfide isomerase, ubiquitinated proteins, glucose regulated protein 78 and CCAAT-enhancer-binding protein homologous protein, and induced the activation of caspase-4 and caspase-3.	3-methyladenine	27-31	caspase 3	Homo sapiens	248-257
26002468-3	2015	We showed that autophagy was induced in an mTORC1-dependent way and played a protective role against PA-induced apoptosis, which was verified by pretreatment with 3-methyladenine (3MA) and rapamycin.	3-methyladenine	163-178	CREB regulated transcription coactivator 1	Mus musculus	43-49
26002468-3	2015	We showed that autophagy was induced in an mTORC1-dependent way and played a protective role against PA-induced apoptosis, which was verified by pretreatment with 3-methyladenine (3MA) and rapamycin.	3-methyladenine	180-183	CREB regulated transcription coactivator 1	Mus musculus	43-49
26204837-7	2015	The autophagy inhibitor, 3-methyladenine (3-MA), significantly attenuated fluoxetine-mediated effects on ASC proliferation and SQSTM1/LC3B expression.	3-methyladenine	25-40	sequestosome 1	Homo sapiens	127-133
26204837-7	2015	The autophagy inhibitor, 3-methyladenine (3-MA), significantly attenuated fluoxetine-mediated effects on ASC proliferation and SQSTM1/LC3B expression.	3-methyladenine	25-40	microtubule associated protein 1 light chain 3 beta	Homo sapiens	134-138
26204837-7	2015	The autophagy inhibitor, 3-methyladenine (3-MA), significantly attenuated fluoxetine-mediated effects on ASC proliferation and SQSTM1/LC3B expression.	3-methyladenine	42-46	sequestosome 1	Homo sapiens	127-133
26204837-7	2015	The autophagy inhibitor, 3-methyladenine (3-MA), significantly attenuated fluoxetine-mediated effects on ASC proliferation and SQSTM1/LC3B expression.	3-methyladenine	42-46	microtubule associated protein 1 light chain 3 beta	Homo sapiens	134-138
25042557-6	2015	The autophagy inhibitor 3-methyladenine significantly increased the apoptotic rate induced by olaquindox, which was correlated with increased ratio of Bax/Bcl-2.	3-methyladenine	24-39	BCL2 associated X, apoptosis regulator	Homo sapiens	151-154
25042557-6	2015	The autophagy inhibitor 3-methyladenine significantly increased the apoptotic rate induced by olaquindox, which was correlated with increased ratio of Bax/Bcl-2.	3-methyladenine	24-39	BCL2 apoptosis regulator	Homo sapiens	155-160
25708950-0	2015	Paradoxical effects of the autophagy inhibitor 3-methyladenine on docetaxel-induced toxicity in PC-3 and LNCaP prostate cancer cells.	3-methyladenine	47-62	chromobox 8	Homo sapiens	96-100
25708950-5	2015	PC-3 and LNCaP cells were pre-treated with the autophagy inhibitor 3-methyladenine (5 mM) and then exposed to various concentrations (0-100 muM) of docetaxel.	3-methyladenine	67-82	chromobox 8	Homo sapiens	0-4
25708950-8	2015	Pre-treatment with the autophagy inhibitor, 3-methyladenine (5 mM) significantly protected PC-3 cells against docetaxel-induced cytotoxicity, increased autophagosome formation and apoptosis measured using monodansylcadaverine, annexin V and caspase-3 fluorescence, respectively.	3-methyladenine	44-59	chromobox 8	Homo sapiens	91-95
25708950-8	2015	Pre-treatment with the autophagy inhibitor, 3-methyladenine (5 mM) significantly protected PC-3 cells against docetaxel-induced cytotoxicity, increased autophagosome formation and apoptosis measured using monodansylcadaverine, annexin V and caspase-3 fluorescence, respectively.	3-methyladenine	44-59	annexin A5	Homo sapiens	227-236
25708950-8	2015	Pre-treatment with the autophagy inhibitor, 3-methyladenine (5 mM) significantly protected PC-3 cells against docetaxel-induced cytotoxicity, increased autophagosome formation and apoptosis measured using monodansylcadaverine, annexin V and caspase-3 fluorescence, respectively.	3-methyladenine	44-59	caspase 3	Homo sapiens	241-250
26146058-7	2015	RESULTS: The 3-MA group showed the same inhibitory ability on autophagy with the ASPP2 group, and both of them were able to promote OXA or starvation-induced apoptosis, but the cell apoptosis rate in the 3-MA group was lower than that of the ASPP2 group.	3-methyladenine	13-17	tumor protein p53 binding protein 2	Homo sapiens	81-86
26146058-7	2015	RESULTS: The 3-MA group showed the same inhibitory ability on autophagy with the ASPP2 group, and both of them were able to promote OXA or starvation-induced apoptosis, but the cell apoptosis rate in the 3-MA group was lower than that of the ASPP2 group.	3-methyladenine	13-17	tumor protein p53 binding protein 2	Homo sapiens	242-247
25644394-9	2015	The apoptosis rate decreased significantly in human neutrophils stimulated with anti-LAMP-2 antibody, and this effect was attenuated by the inhibitors of autophagy 3-methyladenine (3MA) and 2-morpholin-4-yl-8-phenylchromen-4-one (LY294002).	3-methyladenine	164-179	lysosomal associated membrane protein 2	Homo sapiens	85-91
26125760-5	2015	Flow cytometry was applied to detect changes in apoptosis of RPMI8226/DOX cells (stained with annexin-V/propidium iodide) caused by inhibition by hydroxychloroquine and 3-methyladenine on autophagy.	3-methyladenine	169-184	annexin A5	Homo sapiens	94-103
25694169-6	2015	In contrast, treatment with either the autophagy inhibitor 3-methyladenine (3MA) or LC3B siRNA reduced LC3B expression, increased 3-NT and 4-HNE levels, and exacerbated TTS to PTS.	3-methyladenine	59-74	microtubule-associated protein 1 light chain 3 beta	Mus musculus	103-107
25694169-6	2015	In contrast, treatment with either the autophagy inhibitor 3-methyladenine (3MA) or LC3B siRNA reduced LC3B expression, increased 3-NT and 4-HNE levels, and exacerbated TTS to PTS.	3-methyladenine	76-79	microtubule-associated protein 1 light chain 3 beta	Mus musculus	103-107
25961745-8	2015	3-MA, NAC and DPI inhibited HG-induced interleukin-6 production in BMSCs.	3-methyladenine	0-4	interleukin 6	Homo sapiens	39-52
25795167-8	2015	In vivo, 3-MA blocks the rapid increase in caspase-3 cleavage induced by the blockade of NMDA receptors and prevents the resulting long-term decrease in Gad67-GFP neurons in layers II-IV.	3-methyladenine	9-13	caspase 3	Mus musculus	43-52
25212667-7	2015	3-methyladenine (3-MA) was found to inhibit autophagy and the expression of Beclin 1 and significantly enhanced nutrient depletion-induced apoptosis and death.	3-methyladenine	0-15	beclin 1	Homo sapiens	76-84
25212667-7	2015	3-methyladenine (3-MA) was found to inhibit autophagy and the expression of Beclin 1 and significantly enhanced nutrient depletion-induced apoptosis and death.	3-methyladenine	17-21	beclin 1	Homo sapiens	76-84
26137056-7	2015	However, the autophagy inhibitor 3-methyladenine (3-MA) inhibited the expression of the autophagy-associated protein Beclin-1 and reduced the accumulation of autophagic vacuoles induced by MG-132.	3-methyladenine	33-48	beclin 1	Homo sapiens	117-125
26137056-7	2015	However, the autophagy inhibitor 3-methyladenine (3-MA) inhibited the expression of the autophagy-associated protein Beclin-1 and reduced the accumulation of autophagic vacuoles induced by MG-132.	3-methyladenine	50-54	beclin 1	Homo sapiens	117-125
26137056-8	2015	MG-132-induced apoptosis was enhanced by the autophagy inhibitor 3-MA, which may be a result of caspase-3 activation in the EC9706 cells.	3-methyladenine	65-69	caspase 3	Homo sapiens	96-105
25925964-12	2015	Meanwhile, treatment of endothelial cells with autophagy inhibitor 3-methyladenine (3-MA) blocked EGCG-induced expression of CASP9.	3-methyladenine	67-82	caspase 9	Homo sapiens	125-130
25925964-12	2015	Meanwhile, treatment of endothelial cells with autophagy inhibitor 3-methyladenine (3-MA) blocked EGCG-induced expression of CASP9.	3-methyladenine	84-88	caspase 9	Homo sapiens	125-130
25216025-7	2015	Pre-treatment of the cells with class III PI3K inhibitor 3-methyladenine or Atg5 shRNA attenuated JA-induced LC3-II expression and LC3 puncta formation, indicating the involvement of class III PI3K and Atg5.	3-methyladenine	57-72	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	109-112
25216025-7	2015	Pre-treatment of the cells with class III PI3K inhibitor 3-methyladenine or Atg5 shRNA attenuated JA-induced LC3-II expression and LC3 puncta formation, indicating the involvement of class III PI3K and Atg5.	3-methyladenine	57-72	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	131-134
25216025-7	2015	Pre-treatment of the cells with class III PI3K inhibitor 3-methyladenine or Atg5 shRNA attenuated JA-induced LC3-II expression and LC3 puncta formation, indicating the involvement of class III PI3K and Atg5.	3-methyladenine	57-72	autophagy related 5	Homo sapiens	202-206
24902807-9	2015	Importantly, pretreatment with 3-methyladenine (autophagy inhibitor) enhanced while rapamycin (autophagy inducer) decreased the expression of LOX-1, TLR4, and P-P38 MAPK.	3-methyladenine	31-46	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	142-147
24902807-9	2015	Importantly, pretreatment with 3-methyladenine (autophagy inhibitor) enhanced while rapamycin (autophagy inducer) decreased the expression of LOX-1, TLR4, and P-P38 MAPK.	3-methyladenine	31-46	toll-like receptor 4	Mus musculus	149-153
24902807-9	2015	Importantly, pretreatment with 3-methyladenine (autophagy inhibitor) enhanced while rapamycin (autophagy inducer) decreased the expression of LOX-1, TLR4, and P-P38 MAPK.	3-methyladenine	31-46	mitogen-activated protein kinase 14	Mus musculus	161-169
25948188-8	2015	Compared with the YM155 group, the protein levels of LC-3 and caspase-3 were lower in YM155 combined with 3-MA group.	3-methyladenine	106-110	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	53-57
25948188-8	2015	Compared with the YM155 group, the protein levels of LC-3 and caspase-3 were lower in YM155 combined with 3-MA group.	3-methyladenine	106-110	caspase 3	Homo sapiens	62-71
26072619-4	2015	Histologic changes and the concentration of related inflammatory factors in the damaged lung tissue were examined at 48 h after opteration, at the same time, the effect of 3-MA on the expression of LC-3 II and Beclin-1 was examined through reverse transcriptase polymerase chain reaction technique (RT-PCR).	3-methyladenine	172-176	beclin 1	Rattus norvegicus	210-218
25807554-6	2015	Compared with PC-9/wt cells, both PC-9/gefB4 and PC-9/gefE3 cells demonstrated higher basal LC3-II levels which were inhibited by 3-methyladenine (3-MA, an autophagy inhibitor) and potentiated by chloroquine (CQ, an inhibitor of autophagolysosomes formation), indicating elevated autophagy in PC-9/gef cells.	3-methyladenine	130-145	proprotein convertase subtilisin/kexin type 9	Homo sapiens	34-38
25807554-6	2015	Compared with PC-9/wt cells, both PC-9/gefB4 and PC-9/gefE3 cells demonstrated higher basal LC3-II levels which were inhibited by 3-methyladenine (3-MA, an autophagy inhibitor) and potentiated by chloroquine (CQ, an inhibitor of autophagolysosomes formation), indicating elevated autophagy in PC-9/gef cells.	3-methyladenine	130-145	proprotein convertase subtilisin/kexin type 9	Homo sapiens	34-38
25807554-6	2015	Compared with PC-9/wt cells, both PC-9/gefB4 and PC-9/gefE3 cells demonstrated higher basal LC3-II levels which were inhibited by 3-methyladenine (3-MA, an autophagy inhibitor) and potentiated by chloroquine (CQ, an inhibitor of autophagolysosomes formation), indicating elevated autophagy in PC-9/gef cells.	3-methyladenine	130-145	proprotein convertase subtilisin/kexin type 9	Homo sapiens	34-38
25807554-7	2015	3-MA and CQ concentration-dependently inhibited cell survival of both PC-9wt and PC-9/gef cells, suggesting that autophagy may be pro-survival.	3-methyladenine	0-4	proprotein convertase subtilisin/kexin type 9	Homo sapiens	70-74
25639566-4	2015	Incubation of 3-methyladenine (an autophagy inhibitor) prevented arsenite-induced LC3-II elevation, autolysosome formation, reduction in GAP 43 (a biomarker of neurite outgrowth), caspase 3 activation and neuronal cell loss.	3-methyladenine	14-29	growth associated protein 43	Rattus norvegicus	137-143
25639566-4	2015	Incubation of 3-methyladenine (an autophagy inhibitor) prevented arsenite-induced LC3-II elevation, autolysosome formation, reduction in GAP 43 (a biomarker of neurite outgrowth), caspase 3 activation and neuronal cell loss.	3-methyladenine	14-29	caspase 3	Rattus norvegicus	180-189
25199507-13	2015	We, then observed whether the hypoxic and serum-free conditions could change the effect of KAI1 on cell survival and whether the pretreatment of 3-MA could inhibit the effect of hypoxic and serum-free conditions on KAI1 function.	3-methyladenine	145-149	CD82 molecule	Homo sapiens	215-219
25534115-6	2015	Further experiments with ASPP2 RNA interference and autophagy inhibitor (3-methyladenine, 3-MA) confirmed that ASPP2 enhanced HCT116 p53(-/-) cell apoptosis via inhibiting the autophagy.	3-methyladenine	73-88	tumor protein p53 binding protein 2	Homo sapiens	111-116
25534115-6	2015	Further experiments with ASPP2 RNA interference and autophagy inhibitor (3-methyladenine, 3-MA) confirmed that ASPP2 enhanced HCT116 p53(-/-) cell apoptosis via inhibiting the autophagy.	3-methyladenine	90-94	tumor protein p53 binding protein 2	Homo sapiens	111-116
25434876-7	2015	Combined inhibition of 3-MA and PI significantly increased the accumulation of A53T alpha-syn as compared with treatment using either single agent.	3-methyladenine	23-27	synuclein alpha	Rattus norvegicus	84-93
25607473-5	2015	LC3B inhibition was achieved by small-interfering RNA (siRNA) targeting LC3B or by treatment with 3-methyladenine (3-MA).	3-methyladenine	98-113	microtubule associated protein 1 light chain 3 beta	Homo sapiens	0-4
25607473-5	2015	LC3B inhibition was achieved by small-interfering RNA (siRNA) targeting LC3B or by treatment with 3-methyladenine (3-MA).	3-methyladenine	115-119	microtubule associated protein 1 light chain 3 beta	Homo sapiens	0-4
25607473-9	2015	LC3B siRNA and 3-MA treatment each attenuated hypoxia-induced LC3B expression, along with migration and invasion, and this was associated with a decrease in RhoA expression and disorganization of the actin cytoskeleton.	3-methyladenine	15-19	microtubule associated protein 1 light chain 3 beta	Homo sapiens	62-66
25607473-9	2015	LC3B siRNA and 3-MA treatment each attenuated hypoxia-induced LC3B expression, along with migration and invasion, and this was associated with a decrease in RhoA expression and disorganization of the actin cytoskeleton.	3-methyladenine	15-19	ras homolog family member A	Homo sapiens	157-161
25779723-9	2015	Surprisingly, the radiosensitizing effect of 3-methyladenine was also observed in ATG7 and LC3b deficient cells and was associated with attenuated gamma-H2AX formation and DNA damage repair.	3-methyladenine	45-60	autophagy related 7	Homo sapiens	82-86
25779723-9	2015	Surprisingly, the radiosensitizing effect of 3-methyladenine was also observed in ATG7 and LC3b deficient cells and was associated with attenuated gamma-H2AX formation and DNA damage repair.	3-methyladenine	45-60	microtubule associated protein 1 light chain 3 beta	Homo sapiens	91-95
25220423-7	2015	To explore the role of autophagy, glioma cells were treated with 3-methyladenine or siRNA for autophagy-related gene 5, and it was demonstrated that inhibition of autophagy further strengthened the radiosensitizing effects of STAT3 inhibition.	3-methyladenine	65-80	signal transducer and activator of transcription 3	Homo sapiens	226-231
26394653-7	2015	Autophagy inhibitors, 3-methyladenine (3-MA) and bafilomycin A1, enhanced TDT-induced cell death.	3-methyladenine	22-37	DNA nucleotidylexotransferase	Homo sapiens	74-77
26394653-7	2015	Autophagy inhibitors, 3-methyladenine (3-MA) and bafilomycin A1, enhanced TDT-induced cell death.	3-methyladenine	39-43	DNA nucleotidylexotransferase	Homo sapiens	74-77
26394653-8	2015	3-MA pretreatment enhanced the TDT-induced up-regulation of Bax and cleaved-PARP.	3-methyladenine	0-4	DNA nucleotidylexotransferase	Homo sapiens	31-34
26394653-8	2015	3-MA pretreatment enhanced the TDT-induced up-regulation of Bax and cleaved-PARP.	3-methyladenine	0-4	BCL2 associated X, apoptosis regulator	Homo sapiens	60-63
26394653-8	2015	3-MA pretreatment enhanced the TDT-induced up-regulation of Bax and cleaved-PARP.	3-methyladenine	0-4	collagen type XI alpha 2 chain	Homo sapiens	76-80
25484073-8	2015	The SUMO1-mediated increase in Abeta was reduced by the autophagy inhibitors (3-methyladenine or wortmannin) or genetic inhibitors (siRNA targeting ATG5, ATG7, ATG12, or HIF1A), respectively.	3-methyladenine	78-93	small ubiquitin-like modifier 1	Mus musculus	4-9
25484073-8	2015	The SUMO1-mediated increase in Abeta was reduced by the autophagy inhibitors (3-methyladenine or wortmannin) or genetic inhibitors (siRNA targeting ATG5, ATG7, ATG12, or HIF1A), respectively.	3-methyladenine	78-93	histocompatibility 2, class II antigen A, beta 1	Mus musculus	31-36
25831014-5	2015	Inhibition of autophagy using pharmacological inhibitors, such as 3-methyladenine and bafilomycin A1, or silencing of the autophagy genes ATG12 or BECN1 decreased the Stx2-induced death in Caco-2 cells.	3-methyladenine	66-81	syntaxin 2	Homo sapiens	167-171
25411381-10	2015	Finally, we provided evidence that pharmacological inhibition of autophagy using 3-methyladenine (3-MA) or down-regulation of autophagy-related protein 5 (Atg5) significantly potentiated Epac1-promoted cardiomyocyte hypertrophy.	3-methyladenine	81-96	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	187-192
25411381-10	2015	Finally, we provided evidence that pharmacological inhibition of autophagy using 3-methyladenine (3-MA) or down-regulation of autophagy-related protein 5 (Atg5) significantly potentiated Epac1-promoted cardiomyocyte hypertrophy.	3-methyladenine	98-102	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	187-192
26021729-7	2015	The increased expression of the autophagic proteins, LC3-II and beclin1, can be reversed by 3-MA and z-vad-fmk pretreatment.	3-methyladenine	92-96	beclin 1	Homo sapiens	64-71
26021729-8	2015	3-MA and Atg5 siRNA increased the ox-LDL-induced increases of the p53 protein level and the annexin V-positive staining, which was decreased by z-vad-fmk.	3-methyladenine	0-4	tumor protein p53	Homo sapiens	66-69
26221173-7	2015	Furthermore, 3-methyladenine (3-MA, autophagy inhibitor) effectively blocked the MEPT-induced cytotoxicity of HSC-4 cells and triggered the activation of p38 and extracellular signal-regulated kinases (ERK) proteins.	3-methyladenine	13-28	mitogen-activated protein kinase 1	Homo sapiens	154-157
26221173-7	2015	Furthermore, 3-methyladenine (3-MA, autophagy inhibitor) effectively blocked the MEPT-induced cytotoxicity of HSC-4 cells and triggered the activation of p38 and extracellular signal-regulated kinases (ERK) proteins.	3-methyladenine	13-28	mitogen-activated protein kinase 1	Homo sapiens	162-200
26221173-7	2015	Furthermore, 3-methyladenine (3-MA, autophagy inhibitor) effectively blocked the MEPT-induced cytotoxicity of HSC-4 cells and triggered the activation of p38 and extracellular signal-regulated kinases (ERK) proteins.	3-methyladenine	13-28	mitogen-activated protein kinase 1	Homo sapiens	202-205
26221173-7	2015	Furthermore, 3-methyladenine (3-MA, autophagy inhibitor) effectively blocked the MEPT-induced cytotoxicity of HSC-4 cells and triggered the activation of p38 and extracellular signal-regulated kinases (ERK) proteins.	3-methyladenine	30-34	mitogen-activated protein kinase 1	Homo sapiens	154-157
26221173-7	2015	Furthermore, 3-methyladenine (3-MA, autophagy inhibitor) effectively blocked the MEPT-induced cytotoxicity of HSC-4 cells and triggered the activation of p38 and extracellular signal-regulated kinases (ERK) proteins.	3-methyladenine	30-34	mitogen-activated protein kinase 1	Homo sapiens	162-200
26221173-7	2015	Furthermore, 3-methyladenine (3-MA, autophagy inhibitor) effectively blocked the MEPT-induced cytotoxicity of HSC-4 cells and triggered the activation of p38 and extracellular signal-regulated kinases (ERK) proteins.	3-methyladenine	30-34	mitogen-activated protein kinase 1	Homo sapiens	202-205
25351442-11	2015	It was considered that the autophagy inhibitor 3-MA suppressed a protective mechanism induced by Hsp90 inhibitor in tumor cells and induced apoptosis.	3-methyladenine	47-51	heat shock protein 90 alpha family class A member 1	Homo sapiens	97-102
25854934-9	2015	The downregulation of BACE1 by LTG treatment was prevented by the autophagy inhibitor 3-Methyladenine.	3-methyladenine	86-101	beta-secretase 1	Homo sapiens	22-27
25339775-6	2015	In contrast, the autophagy inhibitors hydroxychloroquine (HCQ), 3-methyladenine (3-MA), and bafilomycin A1 (BafA1) prevented ENT1 degradation and enhanced RBV antiviral activity.	3-methyladenine	64-79	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	125-129
25339775-6	2015	In contrast, the autophagy inhibitors hydroxychloroquine (HCQ), 3-methyladenine (3-MA), and bafilomycin A1 (BafA1) prevented ENT1 degradation and enhanced RBV antiviral activity.	3-methyladenine	81-85	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	125-129
25590369-7	2015	LC3II positive cells in the cortex were decreased significantly by the treatment with both emodin and 3-methyladenine.	3-methyladenine	102-117	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	0-5
25590369-8	2015	Furthermore, emodin and 3-methyladenine could increase B-cell lymphoma 2 while decreasing Beclin-1 and hVps34 expressions, which were induced by amyloid-beta 25-35.	3-methyladenine	24-39	beclin 1	Rattus norvegicus	90-98
25590369-8	2015	Furthermore, emodin and 3-methyladenine could increase B-cell lymphoma 2 while decreasing Beclin-1 and hVps34 expressions, which were induced by amyloid-beta 25-35.	3-methyladenine	24-39	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	103-109
25490024-8	2014	Early stage autophagy inhibitor 3-MA prevented LC3-II accumulation with combined cediranib/quinacrine/hypoxia and substantially attenuated the associated reduction in cell viability.	3-methyladenine	32-36	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	47-50
25132643-8	2014	Co-treating cells with 2",3"-DMF and 3-methyladenine, an inhibitor of LC3 lipidation, reduced the activation of caspase-8.	3-methyladenine	37-52	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	70-73
25132643-8	2014	Co-treating cells with 2",3"-DMF and 3-methyladenine, an inhibitor of LC3 lipidation, reduced the activation of caspase-8.	3-methyladenine	37-52	caspase 8	Homo sapiens	112-121
24890505-4	2014	Using 3-methyladenine (3-MA) and rapamycin to regulate the activity of mTOR, it was found that the efficiency of neuronal differentiation was affected.	3-methyladenine	6-21	mechanistic target of rapamycin kinase	Homo sapiens	71-75
24890505-4	2014	Using 3-methyladenine (3-MA) and rapamycin to regulate the activity of mTOR, it was found that the efficiency of neuronal differentiation was affected.	3-methyladenine	23-27	mechanistic target of rapamycin kinase	Homo sapiens	71-75
25135709-3	2014	Accordingly, in the present study, we aimed to determine the alterations of specific mitochondrial biogenesis markers and mitochondrial function in 3-MA-injected rats following amyloid beta (Abeta) insult.	3-methyladenine	148-152	amyloid beta precursor protein	Rattus norvegicus	191-196
25135709-7	2014	Also, activities of tricarboxylic acid cycle (TCA) enzymes such as Aconitase, a-ketoglutarate dehydrogenase, and malate dehydrogenase reduced in the presence of 3-MA with or without Abeta insult.	3-methyladenine	161-165	amyloid beta precursor protein	Rattus norvegicus	182-187
25135709-10	2014	Our results suggest that 3-MA amplified deleterious effects of Abeta by targeting central molecule Akt.	3-methyladenine	25-29	amyloid beta precursor protein	Rattus norvegicus	63-68
25135709-10	2014	Our results suggest that 3-MA amplified deleterious effects of Abeta by targeting central molecule Akt.	3-methyladenine	25-29	AKT serine/threonine kinase 1	Rattus norvegicus	99-102
25019701-0	2014	3-Methyladenine can depress drug efflux transporters via blocking the PI3K-AKT-mTOR pathway thus sensitizing MDR cancer to chemotherapy.	3-methyladenine	0-15	mechanistic target of rapamycin kinase	Mus musculus	79-83
25295079-4	2014	In addition, western blot analysis was performed to determine the effect of 3-methyl adenine (3-MA) activity on the inhibition of autophagy, SB203580 inhibition of the p38-mitogen-activated protein kinase (MAPK) pathway, and Beclin 1, LC3, p62, p38 and phosphorylated (p)-p38 protein expression.	3-methyladenine	76-92	mitogen-activated protein kinase 14	Homo sapiens	206-210
25295079-4	2014	In addition, western blot analysis was performed to determine the effect of 3-methyl adenine (3-MA) activity on the inhibition of autophagy, SB203580 inhibition of the p38-mitogen-activated protein kinase (MAPK) pathway, and Beclin 1, LC3, p62, p38 and phosphorylated (p)-p38 protein expression.	3-methyladenine	76-92	mitogen-activated protein kinase 14	Homo sapiens	168-171
25295079-4	2014	In addition, western blot analysis was performed to determine the effect of 3-methyl adenine (3-MA) activity on the inhibition of autophagy, SB203580 inhibition of the p38-mitogen-activated protein kinase (MAPK) pathway, and Beclin 1, LC3, p62, p38 and phosphorylated (p)-p38 protein expression.	3-methyladenine	94-98	mitogen-activated protein kinase 14	Homo sapiens	206-210
25295079-4	2014	In addition, western blot analysis was performed to determine the effect of 3-methyl adenine (3-MA) activity on the inhibition of autophagy, SB203580 inhibition of the p38-mitogen-activated protein kinase (MAPK) pathway, and Beclin 1, LC3, p62, p38 and phosphorylated (p)-p38 protein expression.	3-methyladenine	94-98	beclin 1	Homo sapiens	225-233
25295079-4	2014	In addition, western blot analysis was performed to determine the effect of 3-methyl adenine (3-MA) activity on the inhibition of autophagy, SB203580 inhibition of the p38-mitogen-activated protein kinase (MAPK) pathway, and Beclin 1, LC3, p62, p38 and phosphorylated (p)-p38 protein expression.	3-methyladenine	94-98	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	235-238
25295079-4	2014	In addition, western blot analysis was performed to determine the effect of 3-methyl adenine (3-MA) activity on the inhibition of autophagy, SB203580 inhibition of the p38-mitogen-activated protein kinase (MAPK) pathway, and Beclin 1, LC3, p62, p38 and phosphorylated (p)-p38 protein expression.	3-methyladenine	94-98	nucleoporin 62	Homo sapiens	240-243
25295079-4	2014	In addition, western blot analysis was performed to determine the effect of 3-methyl adenine (3-MA) activity on the inhibition of autophagy, SB203580 inhibition of the p38-mitogen-activated protein kinase (MAPK) pathway, and Beclin 1, LC3, p62, p38 and phosphorylated (p)-p38 protein expression.	3-methyladenine	94-98	mitogen-activated protein kinase 14	Homo sapiens	168-171
25295079-4	2014	In addition, western blot analysis was performed to determine the effect of 3-methyl adenine (3-MA) activity on the inhibition of autophagy, SB203580 inhibition of the p38-mitogen-activated protein kinase (MAPK) pathway, and Beclin 1, LC3, p62, p38 and phosphorylated (p)-p38 protein expression.	3-methyladenine	94-98	mitogen-activated protein kinase 14	Homo sapiens	245-248
25342320-10	2014	The autophagy-specific inhibitor 3-Methyladenine (3-MA) inhibits the expression of DRAM1 and LC3II/I and exacerbates OGD/R-induced cell injury.	3-methyladenine	33-48	DNA-damage regulated autophagy modulator 1	Mus musculus	83-88
25342320-10	2014	The autophagy-specific inhibitor 3-Methyladenine (3-MA) inhibits the expression of DRAM1 and LC3II/I and exacerbates OGD/R-induced cell injury.	3-methyladenine	33-48	liver cell immortalization	Mus musculus	93-100
25342320-10	2014	The autophagy-specific inhibitor 3-Methyladenine (3-MA) inhibits the expression of DRAM1 and LC3II/I and exacerbates OGD/R-induced cell injury.	3-methyladenine	50-54	DNA-damage regulated autophagy modulator 1	Mus musculus	83-88
25342320-10	2014	The autophagy-specific inhibitor 3-Methyladenine (3-MA) inhibits the expression of DRAM1 and LC3II/I and exacerbates OGD/R-induced cell injury.	3-methyladenine	50-54	liver cell immortalization	Mus musculus	93-100
25088259-0	2014	Inhibition of autophagy by 3-MA potentiates purvalanol-induced apoptosis in Bax deficient HCT 116 colon cancer cells.	3-methyladenine	27-31	BCL2 associated X, apoptosis regulator	Homo sapiens	76-79
25088259-8	2014	Inhibition of autophagy by 3-MA treatment enhanced the purvalanol induced apoptotic cell death in HCT 116 Bax(-/-) cells.	3-methyladenine	27-31	BCL2 associated X, apoptosis regulator	Homo sapiens	106-109
24166503-8	2014	An immunocytochemical study of hnRNP A1 and LC3-II and the inhibition of autophagy by 3-methyladenine and ATG7, p62 and BAG3 siRNA showed that miR-18a and hnRNP A1 formed a complex that was degraded through the autophagolysosomal pathway.	3-methyladenine	86-101	microRNA 18a	Homo sapiens	143-150
25110043-5	2014	3-Methyladenine, an autophagy inhibitor, not only increased cell viability through inhibiting autophagic cell death and apoptosis, but also reversed the upregulation of Beclin-1 gene and the downregulation of Bcl-2 gene in the Raji cells induced by As2O3.	3-methyladenine	0-15	beclin 1	Homo sapiens	169-177
25110043-5	2014	3-Methyladenine, an autophagy inhibitor, not only increased cell viability through inhibiting autophagic cell death and apoptosis, but also reversed the upregulation of Beclin-1 gene and the downregulation of Bcl-2 gene in the Raji cells induced by As2O3.	3-methyladenine	0-15	BCL2 apoptosis regulator	Homo sapiens	209-214
24838486-6	2014	Moreover, when pretreated with the autophagy inhibitor 3-MA, the eNOS expression was obviously inhibited and the ET-1 expression was reversed.	3-methyladenine	55-59	endothelin 1	Homo sapiens	113-117
24970676-8	2014	The transformation of LC3-I to LC3-II which was induced by TM, was reversed following treatment with 3-MA.	3-methyladenine	101-105	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	22-25
24970676-8	2014	The transformation of LC3-I to LC3-II which was induced by TM, was reversed following treatment with 3-MA.	3-methyladenine	101-105	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	31-34
25165883-10	2014	Second, protection by PPARalpha activation was due to the induction of autophagy because inhibition of autophagy by 3-methyladenine or Atg7 siRNA reversed liver protection and inflammation.	3-methyladenine	116-131	peroxisome proliferator activated receptor alpha	Mus musculus	22-31
24889814-7	2014	In accordance with morphological observation, 3-MA, a specific inhibitor of PI3K kinase class III, can inhibit the autophagic vesicle formation induced by ANK-199.	3-methyladenine	46-50	ankyrin 1	Homo sapiens	155-158
24823293-8	2014	Depletion of ATG7 or co-treatment of cells with BO-1012 and either 3-methyladenine or bafilomycin A1, two inhibitors of autophagy, not only reduced CHK1 phosphorylation and disrupted S phase arrest, but also increased cleavage of caspase-9 and PARP, and cell death.	3-methyladenine	67-82	checkpoint kinase 1	Homo sapiens	148-152
24823293-8	2014	Depletion of ATG7 or co-treatment of cells with BO-1012 and either 3-methyladenine or bafilomycin A1, two inhibitors of autophagy, not only reduced CHK1 phosphorylation and disrupted S phase arrest, but also increased cleavage of caspase-9 and PARP, and cell death.	3-methyladenine	67-82	caspase 9	Homo sapiens	230-239
24823293-8	2014	Depletion of ATG7 or co-treatment of cells with BO-1012 and either 3-methyladenine or bafilomycin A1, two inhibitors of autophagy, not only reduced CHK1 phosphorylation and disrupted S phase arrest, but also increased cleavage of caspase-9 and PARP, and cell death.	3-methyladenine	67-82	collagen type XI alpha 2 chain	Homo sapiens	244-248
25034786-2	2014	In the present study, clioquinol was found to trigger autophagy by inducing LC3 lipidation and autophagosome formation which was abolished by an autophagy inhibitor 3-methyladenine.	3-methyladenine	165-180	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	76-79
24847907-7	2014	Ang II (10(-7) mol/L, 48 h)-induced increase in the LC3-II to LC3-I ratio, the formation of autophagosomes, expression of beclin-1 and decrease in the expression of SQSTM1/p62 were also inhibited by pretreatment with 3-methyladenine or bafilomycin A1 (inhibitors of autophagy), olmesartan and candesartan (in dose-dependent manners), apocynin, 5HD, and siRNA Atg5.	3-methyladenine	217-232	angiotensinogen	Rattus norvegicus	0-6
24847907-7	2014	Ang II (10(-7) mol/L, 48 h)-induced increase in the LC3-II to LC3-I ratio, the formation of autophagosomes, expression of beclin-1 and decrease in the expression of SQSTM1/p62 were also inhibited by pretreatment with 3-methyladenine or bafilomycin A1 (inhibitors of autophagy), olmesartan and candesartan (in dose-dependent manners), apocynin, 5HD, and siRNA Atg5.	3-methyladenine	217-232	sequestosome 1	Rattus norvegicus	165-171
24799628-7	2014	3-Methyladenine and chloroquine, inhibitors of autophagy, decreased the induction of inflammatory responses in TLR2 KO macrophages.	3-methyladenine	0-15	toll-like receptor 2	Mus musculus	111-115
24644146-10	2014	Cyanidin and 3-MA similarly reduced the cell-death rate, and Atg5-12 and Beclin 1 expression.	3-methyladenine	13-17	autophagy related 5	Homo sapiens	61-65
24966801-10	2014	Inhibition of autophagy, either by Beclin1 knockdown or by 3-methyladenine-mediated inhibition of caspase-3/7, suppressed the anti-proliferative effects of metformin on endometrial cancer cells.	3-methyladenine	59-74	caspase 3	Homo sapiens	98-109
24530860-7	2014	Attenuation of autophagosomal activity by 3-methyladenine increases DEPP protein levels while activation of autophagy by rapamycin reduced DEPP protein levels.	3-methyladenine	42-57	DEPP1 autophagy regulator	Homo sapiens	68-72
24434776-10	2014	Inhibiting autophagy with 3-methyladenine or beclin 1 siRNA obviously increased radioresistance in folliculin deficient cells.	3-methyladenine	26-41	folliculin	Homo sapiens	99-109
24440234-9	2014	Autophagy inhibition by wortmannin, 3-methyladenine and chloroquine increased mitochondrial hypopolarization as well as caspase-9 and 3 dependent cell death.	3-methyladenine	36-51	caspase 9	Homo sapiens	120-129
24718323-9	2014	beta-catenin degradation was downregulated by matrine and rapamycin, a foregone chemical agonist of autophagy, whereas it was upregulated by 3-methyladenine, a specific inhibitor of autophagy.	3-methyladenine	141-156	catenin beta 1	Rattus norvegicus	0-12
24491919-11	2014	3-MA, CQ, and a lysosomal inhibitor, E64c, inhibited cTnI proteolysis and improved contractile dysfunction after MDMA administration.	3-methyladenine	0-4	troponin I3, cardiac type	Rattus norvegicus	53-57
24631374-8	2014	We found that the autophagy inhibitor 3-methyladenine administered after Rap treatment completely reverted the increased phosphorylation of eIF2alpha and p70S6K inactivation, and blocked the formation of autophagosome-like structures restoring the UPR.	3-methyladenine	38-53	eukaryotic translation initiation factor 2A	Homo sapiens	140-149
24631374-8	2014	We found that the autophagy inhibitor 3-methyladenine administered after Rap treatment completely reverted the increased phosphorylation of eIF2alpha and p70S6K inactivation, and blocked the formation of autophagosome-like structures restoring the UPR.	3-methyladenine	38-53	ribosomal protein S6 kinase B1	Homo sapiens	154-160
24626522-9	2014	Treatment with the autophagy inhibitor 3-methyladenine (3-MA) significantly enhanced the apoptosis induced by apigenin, which was accompanied by an increase in the levels of PARP cleavage.	3-methyladenine	39-54	poly(ADP-ribose) polymerase 1	Homo sapiens	174-178
24626522-9	2014	Treatment with the autophagy inhibitor 3-methyladenine (3-MA) significantly enhanced the apoptosis induced by apigenin, which was accompanied by an increase in the levels of PARP cleavage.	3-methyladenine	56-60	poly(ADP-ribose) polymerase 1	Homo sapiens	174-178
24359187-6	2014	In the G93A-NSC cells, there was a more marked accumulation of the LC3-II autophagy protein, attributable to autophagic stress; 3-methyladenine, which acts on initiation of autophagy, fully rescued G93A-NSC viability and reduced the activation of caspase 3/7 indicating this was a secondary event; the metabolic handling of hypoxia was inappropriate possibly contributing to the autophagic stress.	3-methyladenine	128-143	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	67-70
24359187-6	2014	In the G93A-NSC cells, there was a more marked accumulation of the LC3-II autophagy protein, attributable to autophagic stress; 3-methyladenine, which acts on initiation of autophagy, fully rescued G93A-NSC viability and reduced the activation of caspase 3/7 indicating this was a secondary event; the metabolic handling of hypoxia was inappropriate possibly contributing to the autophagic stress.	3-methyladenine	128-143	caspase 3	Mus musculus	247-258
24449278-7	2014	However, addition of 3-methyladenine, a widely used autophagy inhibitor, in combination with H2O2 induced more cell death in WT than in Sirt1-/- mESCs.	3-methyladenine	21-36	sirtuin 1	Homo sapiens	136-141
24522112-7	2014	Ghrelin, like an autophagy inhibitor, 3-MA, inhibited the DOX-induced autophagy and attenuated cardiomyocyte apoptosis and size decrease.	3-methyladenine	38-42	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
24463210-9	2014	Autophagy inhibitor, 3-methyladenine (3-MA) treatment of mouse bone marrow derived non-adherent mononuclear cells showed a significant decrease in muXg induced Atg5 and LC3 mRNA expression in the presence or absence of RANK ligand (RANKL) stimulation.	3-methyladenine	21-36	autophagy related 5	Mus musculus	160-164
24463210-9	2014	Autophagy inhibitor, 3-methyladenine (3-MA) treatment of mouse bone marrow derived non-adherent mononuclear cells showed a significant decrease in muXg induced Atg5 and LC3 mRNA expression in the presence or absence of RANK ligand (RANKL) stimulation.	3-methyladenine	21-36	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	169-172
24463210-9	2014	Autophagy inhibitor, 3-methyladenine (3-MA) treatment of mouse bone marrow derived non-adherent mononuclear cells showed a significant decrease in muXg induced Atg5 and LC3 mRNA expression in the presence or absence of RANK ligand (RANKL) stimulation.	3-methyladenine	21-36	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	219-230
24463210-9	2014	Autophagy inhibitor, 3-methyladenine (3-MA) treatment of mouse bone marrow derived non-adherent mononuclear cells showed a significant decrease in muXg induced Atg5 and LC3 mRNA expression in the presence or absence of RANK ligand (RANKL) stimulation.	3-methyladenine	21-36	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	232-237
24463210-9	2014	Autophagy inhibitor, 3-methyladenine (3-MA) treatment of mouse bone marrow derived non-adherent mononuclear cells showed a significant decrease in muXg induced Atg5 and LC3 mRNA expression in the presence or absence of RANK ligand (RANKL) stimulation.	3-methyladenine	38-42	autophagy related 5	Mus musculus	160-164
24463210-9	2014	Autophagy inhibitor, 3-methyladenine (3-MA) treatment of mouse bone marrow derived non-adherent mononuclear cells showed a significant decrease in muXg induced Atg5 and LC3 mRNA expression in the presence or absence of RANK ligand (RANKL) stimulation.	3-methyladenine	38-42	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	169-172
24463210-9	2014	Autophagy inhibitor, 3-methyladenine (3-MA) treatment of mouse bone marrow derived non-adherent mononuclear cells showed a significant decrease in muXg induced Atg5 and LC3 mRNA expression in the presence or absence of RANK ligand (RANKL) stimulation.	3-methyladenine	38-42	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	219-230
24463210-9	2014	Autophagy inhibitor, 3-methyladenine (3-MA) treatment of mouse bone marrow derived non-adherent mononuclear cells showed a significant decrease in muXg induced Atg5 and LC3 mRNA expression in the presence or absence of RANK ligand (RANKL) stimulation.	3-methyladenine	38-42	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	232-237
24319109-9	2014	Although rapamycin treatment induced autophagy and led to apoptosis promotion, the pro-apoptotic effect of rapamycin was reversed by the addition of 3-MA, suggesting that mTOR inhibition promotes endometriotic cell apoptosis via autophagy induction.	3-methyladenine	149-153	mechanistic target of rapamycin kinase	Homo sapiens	171-175
24675684-7	2014	Specific inhibition of autophagy by 3-methyladenine and chloroquine had little effect on cell apoptosis but could enhance the pro-apoptotic effects of meloxicam by further upregulating the expression of Bax.	3-methyladenine	36-51	BCL2 associated X, apoptosis regulator	Homo sapiens	203-206
24366666-3	2014	Leucettine L41-triggered autophagy requires the Unc-51-like kinase and is sensitive to the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and 3-methyladenine, suggesting that it acts through the mammalian target of rapamycin (mTOR)/PI3K-dependent pathway.	3-methyladenine	154-169	ribosomal protein L41	Homo sapiens	11-14
24366666-3	2014	Leucettine L41-triggered autophagy requires the Unc-51-like kinase and is sensitive to the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and 3-methyladenine, suggesting that it acts through the mammalian target of rapamycin (mTOR)/PI3K-dependent pathway.	3-methyladenine	154-169	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	91-120
23813779-5	2014	Conversely, autophagy inhibitor 3-methyladenine partly reversed the cytotoxicity and the phosphorylation of AMPK, mTOR and p70 S6K induced by Tan IIA in KBM-5 leukemia cells.	3-methyladenine	32-47	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	108-112
23813779-5	2014	Conversely, autophagy inhibitor 3-methyladenine partly reversed the cytotoxicity and the phosphorylation of AMPK, mTOR and p70 S6K induced by Tan IIA in KBM-5 leukemia cells.	3-methyladenine	32-47	mechanistic target of rapamycin kinase	Homo sapiens	114-118
23813779-5	2014	Conversely, autophagy inhibitor 3-methyladenine partly reversed the cytotoxicity and the phosphorylation of AMPK, mTOR and p70 S6K induced by Tan IIA in KBM-5 leukemia cells.	3-methyladenine	32-47	ribosomal protein S6 kinase B1	Homo sapiens	123-130
24566390-6	2014	The neuroprotection by H3R antagonism is reversed by 3-methyladenine and siRNA for Atg7, and is diminished in Atg5-/- mouse embryonic fibroblasts.	3-methyladenine	53-68	histamine receptor H3	Mus musculus	23-26
24276232-8	2014	Furthermore, treatment with a class III PI3K inhibitor (LY290042 and 3-MA) attenuated the intracellular total cholesterol accumulation induced by ATM activation.	3-methyladenine	69-73	ataxia telangiectasia mutated	Mus musculus	146-149
24122153-9	2014	Moreover, both 3-MA and necrostatin-1 treatment could suppress cleaved caspase-3 and LC3-II production, whereas zVAD treatment could inhibit caspase-3 cleavage but increased LC3-II protein levels at 72 h after ICH.	3-methyladenine	15-19	caspase 3	Mus musculus	71-80
24321340-4	2014	Interestingly, CA-4-mediated apoptotic cell death was further potentiated by pretreatment with autophagy inhibitors (3-methyladenine and bafilomycin A1) or small interfering RNAs against the autophagic genes (Atg5 and Beclin 1).	3-methyladenine	117-132	carbonic anhydrase 4	Homo sapiens	15-19
24333414-8	2014	When the PAN-induced autophagy was inhibited by 3-methyladenine (3-MA) or chloroquine (CQ), podocyte apoptosis increased significantly along with the elevation of active caspase-3.	3-methyladenine	48-63	caspase 3	Homo sapiens	170-179
24333414-8	2014	When the PAN-induced autophagy was inhibited by 3-methyladenine (3-MA) or chloroquine (CQ), podocyte apoptosis increased significantly along with the elevation of active caspase-3.	3-methyladenine	65-69	caspase 3	Homo sapiens	170-179
23849780-0	2014	3-MA inhibits autophagy and favors long-term integration of grafted Gad67-GFP GABAergic precursors in the developing neocortex by preventing apoptosis.	3-methyladenine	0-4	glutamate decarboxylase 1	Homo sapiens	68-73
23849780-9	2014	Quantification of Bax, mitochondrial integrity, caspase-3 cleavage, and caspase-3 immunolocalization and activity showed that 3-MA induced a significant decrease of Gad67-GFP precursor apoptosis.	3-methyladenine	126-130	BCL2 associated X, apoptosis regulator	Homo sapiens	18-21
23849780-9	2014	Quantification of Bax, mitochondrial integrity, caspase-3 cleavage, and caspase-3 immunolocalization and activity showed that 3-MA induced a significant decrease of Gad67-GFP precursor apoptosis.	3-methyladenine	126-130	caspase 3	Homo sapiens	48-57
23849780-9	2014	Quantification of Bax, mitochondrial integrity, caspase-3 cleavage, and caspase-3 immunolocalization and activity showed that 3-MA induced a significant decrease of Gad67-GFP precursor apoptosis.	3-methyladenine	126-130	caspase 3	Homo sapiens	72-81
23849780-9	2014	Quantification of Bax, mitochondrial integrity, caspase-3 cleavage, and caspase-3 immunolocalization and activity showed that 3-MA induced a significant decrease of Gad67-GFP precursor apoptosis.	3-methyladenine	126-130	glutamate decarboxylase 1	Homo sapiens	165-170
23849780-10	2014	In vivo, 3-MA induced, within the first 24 h, a diffuse LC3 pattern of grafted Gad67-GFP precursors, an increase of precursors with neurites, a reduction of the density of caspase-3 immunoreactive cells.	3-methyladenine	9-13	glutamate decarboxylase 1	Homo sapiens	79-84
23849780-10	2014	In vivo, 3-MA induced, within the first 24 h, a diffuse LC3 pattern of grafted Gad67-GFP precursors, an increase of precursors with neurites, a reduction of the density of caspase-3 immunoreactive cells.	3-methyladenine	9-13	caspase 3	Homo sapiens	172-181
24713587-6	2014	In contrast, treatment with the autophagy inhibitor, 3-methyladenine (3-MA) (5 mM), increases cellular HL levels and stimulates HL release.	3-methyladenine	53-68	lipase C, hepatic type	Homo sapiens	103-105
24713587-6	2014	In contrast, treatment with the autophagy inhibitor, 3-methyladenine (3-MA) (5 mM), increases cellular HL levels and stimulates HL release.	3-methyladenine	53-68	lipase C, hepatic type	Homo sapiens	128-130
24713587-6	2014	In contrast, treatment with the autophagy inhibitor, 3-methyladenine (3-MA) (5 mM), increases cellular HL levels and stimulates HL release.	3-methyladenine	70-74	lipase C, hepatic type	Homo sapiens	103-105
24713587-6	2014	In contrast, treatment with the autophagy inhibitor, 3-methyladenine (3-MA) (5 mM), increases cellular HL levels and stimulates HL release.	3-methyladenine	70-74	lipase C, hepatic type	Homo sapiens	128-130
24269624-3	2014	It showed that IL-17 could not only induce B cell autophagy, but also facilitate the myocarditis severity, serum anti-MyHC-alpha autoantibody production and splenic CD38(+) CD138(+) B cell percentages, while the autophagy inhibitor 3-methyladenine attenuated these effects.	3-methyladenine	232-247	interleukin 17A	Mus musculus	15-20
24269624-6	2014	Moreover, elevated autophagy mediated by IL-17 enhanced ubiquitin-proteasome system activity and B cell anti-apoptotic ability by Beclin-1 and p62 through Erk1/2 phosphorylation, and these changes brought by IL-17 could be also inhibited with 3-methyladenine.	3-methyladenine	243-258	interleukin 17A	Mus musculus	41-46
24269624-6	2014	Moreover, elevated autophagy mediated by IL-17 enhanced ubiquitin-proteasome system activity and B cell anti-apoptotic ability by Beclin-1 and p62 through Erk1/2 phosphorylation, and these changes brought by IL-17 could be also inhibited with 3-methyladenine.	3-methyladenine	243-258	interleukin 17A	Mus musculus	208-213
24173208-7	2014	The outcome of autophagy inhibition was determined using 3-methyladenine (3-MA) to detect Annexin V (+), propidium iodide (PI) (-) and acridine orange (+) cells by FACS analysis.	3-methyladenine	74-78	annexin A5	Homo sapiens	90-99
24173208-13	2014	Following 3-MA pretreatment, cisplatin-induced autophagy was found to be markedly reduced (a 3-fold reduction) in wild-type p53 compared to null-type p53 cells.	3-methyladenine	10-14	tumor protein p53	Homo sapiens	124-127
24305604-12	2013	Furthermore, after inhibition of autophagy with 3-Methyladenine (3-MA) or Beclin 1 siRNA, apoptosis induced by paclitaxel was significantly increased in FLCN-deficient UOK257 and ACHN-5968 cells.	3-methyladenine	48-63	folliculin	Homo sapiens	153-157
24305604-12	2013	Furthermore, after inhibition of autophagy with 3-Methyladenine (3-MA) or Beclin 1 siRNA, apoptosis induced by paclitaxel was significantly increased in FLCN-deficient UOK257 and ACHN-5968 cells.	3-methyladenine	65-69	folliculin	Homo sapiens	153-157
24094936-5	2013	Furthermore, we found that autophagy inhibitors (wortmannin, 3-MA or chloroquine) suppressed QDs-induced autophagic flux, partly blocked LTP impairment, coincident with down-regulation of synapsin-I and synapse deficits by QDs in the hippocampal CA1 area.	3-methyladenine	61-65	synapsin I	Homo sapiens	188-198
24094936-5	2013	Furthermore, we found that autophagy inhibitors (wortmannin, 3-MA or chloroquine) suppressed QDs-induced autophagic flux, partly blocked LTP impairment, coincident with down-regulation of synapsin-I and synapse deficits by QDs in the hippocampal CA1 area.	3-methyladenine	61-65	carbonic anhydrase 1	Homo sapiens	246-249
24245991-10	2013	In addition, inhibition of autophagy by 3-MA partly ameliorated seawater-induced ALI, as indicated by reduced lung weight coefficient and TNF-alpha in BALF, as well as increased PaO2.	3-methyladenine	40-44	tumor necrosis factor	Homo sapiens	138-147
23794518-9	2013	In addition, 3-MA application could up-regulate Caspase-3 and PARP expression, compared with the treatment with lapatinib alone.	3-methyladenine	13-17	caspase 3	Homo sapiens	48-57
23794518-9	2013	In addition, 3-MA application could up-regulate Caspase-3 and PARP expression, compared with the treatment with lapatinib alone.	3-methyladenine	13-17	collagen type XI alpha 2 chain	Homo sapiens	62-66
23794518-10	2013	The addition of 3-MA could attenuate the inhibitory role on HER2/AKT/mTOR pathway and the active role on AMPK that was raised by lapatinib.	3-methyladenine	16-20	erb-b2 receptor tyrosine kinase 2	Homo sapiens	60-64
23794518-10	2013	The addition of 3-MA could attenuate the inhibitory role on HER2/AKT/mTOR pathway and the active role on AMPK that was raised by lapatinib.	3-methyladenine	16-20	AKT serine/threonine kinase 1	Homo sapiens	65-68
23794518-10	2013	The addition of 3-MA could attenuate the inhibitory role on HER2/AKT/mTOR pathway and the active role on AMPK that was raised by lapatinib.	3-methyladenine	16-20	mechanistic target of rapamycin kinase	Homo sapiens	69-73
23794518-10	2013	The addition of 3-MA could attenuate the inhibitory role on HER2/AKT/mTOR pathway and the active role on AMPK that was raised by lapatinib.	3-methyladenine	16-20	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	105-109
24273738-12	2013	The mitogen activated protein kinases p38 MAPK and JNK were activated by AA especially when autophagy was inhibited and chemical inhibitors of p38 MAPK and JNK lowered the elevated toxicity of AA produced by 3-MA.	3-methyladenine	208-212	mitogen-activated protein kinase 14	Homo sapiens	38-41
24273738-12	2013	The mitogen activated protein kinases p38 MAPK and JNK were activated by AA especially when autophagy was inhibited and chemical inhibitors of p38 MAPK and JNK lowered the elevated toxicity of AA produced by 3-MA.	3-methyladenine	208-212	mitogen-activated protein kinase 8	Homo sapiens	51-54
24273738-12	2013	The mitogen activated protein kinases p38 MAPK and JNK were activated by AA especially when autophagy was inhibited and chemical inhibitors of p38 MAPK and JNK lowered the elevated toxicity of AA produced by 3-MA.	3-methyladenine	208-212	mitogen-activated protein kinase 14	Homo sapiens	143-146
24273738-12	2013	The mitogen activated protein kinases p38 MAPK and JNK were activated by AA especially when autophagy was inhibited and chemical inhibitors of p38 MAPK and JNK lowered the elevated toxicity of AA produced by 3-MA.	3-methyladenine	208-212	mitogen-activated protein kinase 8	Homo sapiens	156-159
24026338-9	2013	3-Methyladenine (MA), a classical autophagy inhibitor showed increased JNK activation by exposure to papuamine.	3-methyladenine	0-15	mitogen-activated protein kinase 8	Homo sapiens	71-74
24008336-10	2013	Inhibition of autophagy by knockdown of Beclin-1 with siRNA or by an autophagy inhibitor 3"-methyladenine inhibited MCPIP-induced expression of EC markers.	3-methyladenine	89-105	zinc finger CCCH-type containing 12A	Homo sapiens	116-121
24008047-12	2013	However, pretreatment with 3-methyladenine (3MA) a specific inhibitor for autophagy, remarkably strengthened FPN toxicity and further induced activation of caspase-3 in these cells.	3-methyladenine	27-42	caspase 3	Homo sapiens	156-165
24008047-12	2013	However, pretreatment with 3-methyladenine (3MA) a specific inhibitor for autophagy, remarkably strengthened FPN toxicity and further induced activation of caspase-3 in these cells.	3-methyladenine	44-47	caspase 3	Homo sapiens	156-165
24136224-8	2013	The axonal-protective effect of Nmnat3 was inhibited by 3-methyladenine, whereas rapamycin exerted axonal protection after IOP elevation.	3-methyladenine	56-71	nicotinamide nucleotide adenylyltransferase 3	Mus musculus	32-38
24113220-11	2013	Adiponectin-induced reduction of LDLR was blocked by treatment with a specific inhibitor of autophagy, 3-methyladenine.	3-methyladenine	103-118	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
24113220-11	2013	Adiponectin-induced reduction of LDLR was blocked by treatment with a specific inhibitor of autophagy, 3-methyladenine.	3-methyladenine	103-118	low density lipoprotein receptor	Homo sapiens	33-37
24066693-7	2013	Moreover, TNF-alpha-induced NF-kappaB transactivation was suppressed by autophagy inhibitor 3-MA.	3-methyladenine	92-96	tumor necrosis factor	Homo sapiens	10-19
24066693-7	2013	Moreover, TNF-alpha-induced NF-kappaB transactivation was suppressed by autophagy inhibitor 3-MA.	3-methyladenine	92-96	nuclear factor kappa B subunit 1	Homo sapiens	28-37
22795399-9	2013	Furthermore, gp120 induced autophagic proteins and autophagosomes were significantly inhibited by the N-methyl-d-aspartic acid (NMDA) receptor inhibitor MK801, c-Jun N-terminal kinase (JNK) inhibitor SP600125, and the class III phosphoinositide 3-kinase (PI3K) inhibitor 3-methyladenine (3-MA), while there was no change in the cells pretreated with the CXCR4 antagonist AMD3100.	3-methyladenine	271-286	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	13-18
22795399-9	2013	Furthermore, gp120 induced autophagic proteins and autophagosomes were significantly inhibited by the N-methyl-d-aspartic acid (NMDA) receptor inhibitor MK801, c-Jun N-terminal kinase (JNK) inhibitor SP600125, and the class III phosphoinositide 3-kinase (PI3K) inhibitor 3-methyladenine (3-MA), while there was no change in the cells pretreated with the CXCR4 antagonist AMD3100.	3-methyladenine	271-286	mitogen-activated protein kinase 8	Homo sapiens	160-183
22795399-9	2013	Furthermore, gp120 induced autophagic proteins and autophagosomes were significantly inhibited by the N-methyl-d-aspartic acid (NMDA) receptor inhibitor MK801, c-Jun N-terminal kinase (JNK) inhibitor SP600125, and the class III phosphoinositide 3-kinase (PI3K) inhibitor 3-methyladenine (3-MA), while there was no change in the cells pretreated with the CXCR4 antagonist AMD3100.	3-methyladenine	271-286	mitogen-activated protein kinase 8	Homo sapiens	185-188
22795399-9	2013	Furthermore, gp120 induced autophagic proteins and autophagosomes were significantly inhibited by the N-methyl-d-aspartic acid (NMDA) receptor inhibitor MK801, c-Jun N-terminal kinase (JNK) inhibitor SP600125, and the class III phosphoinositide 3-kinase (PI3K) inhibitor 3-methyladenine (3-MA), while there was no change in the cells pretreated with the CXCR4 antagonist AMD3100.	3-methyladenine	288-292	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	13-18
22795399-9	2013	Furthermore, gp120 induced autophagic proteins and autophagosomes were significantly inhibited by the N-methyl-d-aspartic acid (NMDA) receptor inhibitor MK801, c-Jun N-terminal kinase (JNK) inhibitor SP600125, and the class III phosphoinositide 3-kinase (PI3K) inhibitor 3-methyladenine (3-MA), while there was no change in the cells pretreated with the CXCR4 antagonist AMD3100.	3-methyladenine	288-292	mitogen-activated protein kinase 8	Homo sapiens	160-183
22795399-9	2013	Furthermore, gp120 induced autophagic proteins and autophagosomes were significantly inhibited by the N-methyl-d-aspartic acid (NMDA) receptor inhibitor MK801, c-Jun N-terminal kinase (JNK) inhibitor SP600125, and the class III phosphoinositide 3-kinase (PI3K) inhibitor 3-methyladenine (3-MA), while there was no change in the cells pretreated with the CXCR4 antagonist AMD3100.	3-methyladenine	288-292	mitogen-activated protein kinase 8	Homo sapiens	185-188
23892275-12	2013	Pretreatment of PC3 cells with autophagy inhibitor 3-MA (5 mmol/L) or the lysosomal protease inhibitor CQ (10 mumol/L) significantly increased RAB-induced apoptosis.	3-methyladenine	51-55	chromobox 8	Homo sapiens	16-19
23420039-9	2013	Abeta(1-42)-induced Beclin-1 expression was further upregulated by rapamycin but was downregulated by 3-MA.	3-methyladenine	102-106	beclin 1	Rattus norvegicus	20-28
23420039-10	2013	Moreover, cell viability was increased by rapamycin but was decreased by 3-MA, and NSE was decreased by rapamycin but was increased by 3-MA, suggesting that activation of Beclin-1-dependent autophagy before the damage occurred can prevent neuronal cell death, while inhibition of Beclin-1-dependent autophagy can hastened cell death.	3-methyladenine	73-77	beclin 1	Rattus norvegicus	171-179
23420039-10	2013	Moreover, cell viability was increased by rapamycin but was decreased by 3-MA, and NSE was decreased by rapamycin but was increased by 3-MA, suggesting that activation of Beclin-1-dependent autophagy before the damage occurred can prevent neuronal cell death, while inhibition of Beclin-1-dependent autophagy can hastened cell death.	3-methyladenine	135-139	enolase 2	Rattus norvegicus	83-86
23420039-10	2013	Moreover, cell viability was increased by rapamycin but was decreased by 3-MA, and NSE was decreased by rapamycin but was increased by 3-MA, suggesting that activation of Beclin-1-dependent autophagy before the damage occurred can prevent neuronal cell death, while inhibition of Beclin-1-dependent autophagy can hastened cell death.	3-methyladenine	135-139	beclin 1	Rattus norvegicus	171-179
23726866-9	2013	Inhibition of autophagy influx, using 3-methyl-adenine, increased intra- and extracellular levels of Abeta, providing more proof for a protective role of autophagy against oxidative stress.	3-methyladenine	38-54	amyloid beta precursor protein	Homo sapiens	101-106
23644056-5	2013	The I/R-induced increases of protein levels of p53 and LC3-II were significantly inhibited by treatment with propofol, 3-MA or PFT-alpha.	3-methyladenine	119-123	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	47-50
23887605-10	2013	By contrast, treatment for 48 h with pazopanib induces cathepsin B activation and autophagic cell death, markedly reversed by CA074-Me and 3-MA, cathepsin B and autophagic inhibitors, respectively.	3-methyladenine	139-143	cathepsin B	Homo sapiens	55-66
25206520-8	2013	However, injection of 3-methyladenine significantly diminished light chain 3-II and cathepsin B expression.	3-methyladenine	22-37	cathepsin B	Rattus norvegicus	84-95
23743148-6	2013	Pretreatment cells with 3-methyladenine (3-MA), an autophagy inhibitor, not only inhibited the TOCP-induced autophagy, but also reversed the inhibition of neurite outgrowth and the degradation of NF-H, NF-L, and beta-tubulin by TOCP.	3-methyladenine	24-39	neurofilament heavy chain	Homo sapiens	196-200
23743148-6	2013	Pretreatment cells with 3-methyladenine (3-MA), an autophagy inhibitor, not only inhibited the TOCP-induced autophagy, but also reversed the inhibition of neurite outgrowth and the degradation of NF-H, NF-L, and beta-tubulin by TOCP.	3-methyladenine	24-39	neurofilament light chain	Homo sapiens	202-206
23743148-6	2013	Pretreatment cells with 3-methyladenine (3-MA), an autophagy inhibitor, not only inhibited the TOCP-induced autophagy, but also reversed the inhibition of neurite outgrowth and the degradation of NF-H, NF-L, and beta-tubulin by TOCP.	3-methyladenine	41-45	neurofilament heavy chain	Homo sapiens	196-200
23743148-6	2013	Pretreatment cells with 3-methyladenine (3-MA), an autophagy inhibitor, not only inhibited the TOCP-induced autophagy, but also reversed the inhibition of neurite outgrowth and the degradation of NF-H, NF-L, and beta-tubulin by TOCP.	3-methyladenine	41-45	neurofilament light chain	Homo sapiens	202-206
23558089-6	2013	This increased autophagy contributed to cell injury, evidenced by terminal deoxynucleotidyltransferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) co-staining and a protective effect achieved by the autophagy inhibitor 3-methyladenine.	3-methyladenine	228-243	deoxynucleotidyltransferase, terminal	Mus musculus	104-107
23710679-3	2013	In additional experiments, sirtinol and 3-methyladenine (3-MA) were used as inhibitors of SIRT1 and autophagy respectively.	3-methyladenine	40-55	sirtuin 1	Rattus norvegicus	90-95
23710679-3	2013	In additional experiments, sirtinol and 3-methyladenine (3-MA) were used as inhibitors of SIRT1 and autophagy respectively.	3-methyladenine	57-61	sirtuin 1	Rattus norvegicus	90-95
23435577-4	2013	The present study was aimed to establish a flow cytometric method for quantitative detection of Beclin-1 expression by employing the autophagy inhibitor 3-methyladenine as the control.	3-methyladenine	153-168	beclin 1	Homo sapiens	96-104
23583271-13	2013	Importantly, inhibiting autophagy using 3-methyladenine mitigated IGF-1 knockdown-induced preservation of autophagic vacuole formation and inhibition of beta-gal accumulation in the presence of FFA in HepG2 cells.	3-methyladenine	40-55	insulin like growth factor 1	Homo sapiens	66-71
23817040-6	2013	3-MA (3-Methyladenine), an inhibitor of autophagic sequestration blocker, inhibited TIGAR siRNA-enhanced autophagy, as indicated by the decrease in LC-3 II levels.	3-methyladenine	0-4	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	84-89
23817040-6	2013	3-MA (3-Methyladenine), an inhibitor of autophagic sequestration blocker, inhibited TIGAR siRNA-enhanced autophagy, as indicated by the decrease in LC-3 II levels.	3-methyladenine	6-21	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	84-89
23648705-7	2013	Notably, genetic loss of function studies, such as Atg7 knock-down or pharmacological inhibition of autophagy with 3-methyl adenine, suppressed cell death induced by p53--indicating that p53 induces maladaptive autophagy.	3-methyladenine	115-131	transformation related protein 53, pseudogene	Mus musculus	166-169
23648705-7	2013	Notably, genetic loss of function studies, such as Atg7 knock-down or pharmacological inhibition of autophagy with 3-methyl adenine, suppressed cell death induced by p53--indicating that p53 induces maladaptive autophagy.	3-methyladenine	115-131	transformation related protein 53, pseudogene	Mus musculus	187-190
23703965-7	2013	The majority of NSCs were nestin-positive when EGF/bFGF was withdrawn for 3 days and showed enhanced neurite extension, which was suppressed by autophagy antagonist 3-methyladenine.	3-methyladenine	165-180	epidermal growth factor	Rattus norvegicus	47-50
23703965-7	2013	The majority of NSCs were nestin-positive when EGF/bFGF was withdrawn for 3 days and showed enhanced neurite extension, which was suppressed by autophagy antagonist 3-methyladenine.	3-methyladenine	165-180	fibroblast growth factor 2	Rattus norvegicus	51-55
23866663-10	2013	The protein level of beclin-1 and the ratio of LC3 II to LC3 I in cells pretreated with 3-MA were reduced, while that of p62 was increased.	3-methyladenine	88-92	beclin 1	Homo sapiens	21-29
23866663-10	2013	The protein level of beclin-1 and the ratio of LC3 II to LC3 I in cells pretreated with 3-MA were reduced, while that of p62 was increased.	3-methyladenine	88-92	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	47-50
23866663-10	2013	The protein level of beclin-1 and the ratio of LC3 II to LC3 I in cells pretreated with 3-MA were reduced, while that of p62 was increased.	3-methyladenine	88-92	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	57-60
23218525-6	2013	Inhibition of autophagy by 3-MA ameliorated lung I/R injury, as indicated by a reduced lung wet/dry ratio, myeloperoxidase activity, and malondialdehyde concentrations.	3-methyladenine	27-31	myeloperoxidase	Rattus norvegicus	107-122
23563171-7	2013	The augmentation of PCX-induced apoptosis by 3-MA was accompanied by increase in the cytochrome c release from the mitochondria, caspase-3 activity and XIAP downregulation, which suggests that inhibiting autophagy further stimulates the PCX-induced mitochondrion-related (intrinsic) apoptotic pathway by provoking caspase-3 activation.	3-methyladenine	45-49	cytochrome c, somatic	Homo sapiens	85-97
23563171-7	2013	The augmentation of PCX-induced apoptosis by 3-MA was accompanied by increase in the cytochrome c release from the mitochondria, caspase-3 activity and XIAP downregulation, which suggests that inhibiting autophagy further stimulates the PCX-induced mitochondrion-related (intrinsic) apoptotic pathway by provoking caspase-3 activation.	3-methyladenine	45-49	caspase 3	Homo sapiens	129-138
23563171-7	2013	The augmentation of PCX-induced apoptosis by 3-MA was accompanied by increase in the cytochrome c release from the mitochondria, caspase-3 activity and XIAP downregulation, which suggests that inhibiting autophagy further stimulates the PCX-induced mitochondrion-related (intrinsic) apoptotic pathway by provoking caspase-3 activation.	3-methyladenine	45-49	X-linked inhibitor of apoptosis	Homo sapiens	152-156
23563171-7	2013	The augmentation of PCX-induced apoptosis by 3-MA was accompanied by increase in the cytochrome c release from the mitochondria, caspase-3 activity and XIAP downregulation, which suggests that inhibiting autophagy further stimulates the PCX-induced mitochondrion-related (intrinsic) apoptotic pathway by provoking caspase-3 activation.	3-methyladenine	45-49	caspase 3	Homo sapiens	314-323
23508272-8	2013	Reversely, forced activation of AMPK by its activator AICAR or by genetic manipulation caused autophagic death in HT-29 cells, which was inhibited by 3-MA.	3-methyladenine	150-154	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	54-59
23737997-8	2013	Furthermore, an autophagy inhibitor, 3-MA, was used to block the IMD-augmented autophagy level, and then the protection of IMD on cardiomyocyte hypertrophy and apoptosis was almost abrogated.	3-methyladenine	37-41	adrenomedullin 2	Rattus norvegicus	65-68
23737997-8	2013	Furthermore, an autophagy inhibitor, 3-MA, was used to block the IMD-augmented autophagy level, and then the protection of IMD on cardiomyocyte hypertrophy and apoptosis was almost abrogated.	3-methyladenine	37-41	adrenomedullin 2	Rattus norvegicus	123-126
23696801-5	2013	The increase in LC3-II and decrease in SQSTM1 were blocked by the autophagy inhibitor 3-methyl-adenine.	3-methyladenine	86-102	sequestosome 1	Rattus norvegicus	39-45
23603979-7	2013	RESULTS: When the proteasome and macroautophagy in the wild-type and mutant cells were inhibited with epoxomicin and 3-MA, respectively, the cell viability was significantly decreased, and the alpha-synuclein level was increased.	3-methyladenine	117-121	synuclein alpha	Rattus norvegicus	193-208
23518861-10	2013	Our experiments demonstrated that apoptosis suppressed by the knocking down of PP2Ac can be reversed by the administration of 3-methyladenine.	3-methyladenine	126-141	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	79-84
23525265-4	2013	Pretreatment of 1321N1 astrocytoma cells with 3-MA (5 mmol/L) decreased the PCN-induced acidic vesicular organelle and autophagosome formation as measured using acridine orange and green fluorescent protein-LC3 -LC3 fluorescence, respectively.	3-methyladenine	46-50	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	207-210
23525265-4	2013	Pretreatment of 1321N1 astrocytoma cells with 3-MA (5 mmol/L) decreased the PCN-induced acidic vesicular organelle and autophagosome formation as measured using acridine orange and green fluorescent protein-LC3 -LC3 fluorescence, respectively.	3-methyladenine	46-50	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	212-215
23525265-9	2013	Consistent with its paradoxical role in modulating PCN-induced toxicity, 3-MA (5 mmol/L) significantly reduced the PCN-induced production of IL-8, PGE2, and LTB4 in 1321N1 astrocytoma cells but augmented their production in SH-SY5Y neuroblastoma cells.	3-methyladenine	73-77	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
23364609-6	2013	Furthermore, 3-MA treatment significantly reversed the reduction effect of IPost on infarct volume, and in the meantime, inhibited the induction of LC3 and Beclin1.	3-methyladenine	13-17	annexin A3	Rattus norvegicus	148-151
23364609-6	2013	Furthermore, 3-MA treatment significantly reversed the reduction effect of IPost on infarct volume, and in the meantime, inhibited the induction of LC3 and Beclin1.	3-methyladenine	13-17	beclin 1	Rattus norvegicus	156-163
23364609-7	2013	In addition, 3-MA treatment inhibited the antiapoptotic-related protein levels of Bcl-2 and increased the apoptotic-related protein levels of Bad.	3-methyladenine	13-17	BCL2, apoptosis regulator	Rattus norvegicus	82-87
23535229-6	2013	The autophagy inhibitor 3-methyladenine significantly inhibited HO-1 up-regulation and increased the rate of cell death in cells treated with P-VO2, while the HO-1 inhibitor protoporphyrin IX zinc (II) (ZnPP) enhanced the occurrence of cell death in the P-VO2-treated cells while having no effect on the autophagic response induced by P-VO2.	3-methyladenine	24-39	heme oxygenase 1	Homo sapiens	64-68
23592903-10	2013	Treatment with the autophagy inhibitor, 3-methyladenine (3-MA), significantly enhanced the apoptosis induced by apigenin, which was accompanied by an increase in the level of PARP cleavage.	3-methyladenine	40-55	collagen type XI alpha 2 chain	Homo sapiens	175-179
23592903-10	2013	Treatment with the autophagy inhibitor, 3-methyladenine (3-MA), significantly enhanced the apoptosis induced by apigenin, which was accompanied by an increase in the level of PARP cleavage.	3-methyladenine	57-61	collagen type XI alpha 2 chain	Homo sapiens	175-179
23404079-7	2013	The ability of 3-MA to increase matrine-induced apoptosis was further confirmed by Annexin V-FITC/PI staining.	3-methyladenine	15-19	annexin A5	Homo sapiens	83-92
23352508-10	2013	However, pretreatment of cells with the autophagy inhibitor, 3-methyladenine (3MA), remarkably increased CPF toxicity in these cells; this with correlated with increased expression of Bax and decreased expression of Bcl-2 in mitochondria.	3-methyladenine	61-76	BCL2 associated X, apoptosis regulator	Homo sapiens	184-187
23352508-10	2013	However, pretreatment of cells with the autophagy inhibitor, 3-methyladenine (3MA), remarkably increased CPF toxicity in these cells; this with correlated with increased expression of Bax and decreased expression of Bcl-2 in mitochondria.	3-methyladenine	61-76	BCL2 apoptosis regulator	Homo sapiens	216-221
23352508-10	2013	However, pretreatment of cells with the autophagy inhibitor, 3-methyladenine (3MA), remarkably increased CPF toxicity in these cells; this with correlated with increased expression of Bax and decreased expression of Bcl-2 in mitochondria.	3-methyladenine	78-81	BCL2 associated X, apoptosis regulator	Homo sapiens	184-187
23352508-10	2013	However, pretreatment of cells with the autophagy inhibitor, 3-methyladenine (3MA), remarkably increased CPF toxicity in these cells; this with correlated with increased expression of Bax and decreased expression of Bcl-2 in mitochondria.	3-methyladenine	78-81	BCL2 apoptosis regulator	Homo sapiens	216-221
23238993-6	2013	The protective role of autophagy in cell growth inhibition by CP-31398 and RITA is supported by the finding that the AMPK inhibitor compound C or the autophagy inhibitors chloroquine or 3-methyladenine sensitize both pancreatic adenocarcinoma cell lines to the apoptotic response induced by p53-reactivating molecules.	3-methyladenine	186-201	tumor protein p53	Homo sapiens	291-294
23124112-5	2013	Furthermore, we demonstrate that autophagy induced by UCP2 inhibition determines a ROS-dependent cell death, as indicated by the apoptosis decrease in the presence of the autophagy inhibitors chloroquine (CQ) or 3-methyladenine (3-MA), or the radical scavenger NAC.	3-methyladenine	212-227	uncoupling protein 2	Homo sapiens	54-58
23124112-5	2013	Furthermore, we demonstrate that autophagy induced by UCP2 inhibition determines a ROS-dependent cell death, as indicated by the apoptosis decrease in the presence of the autophagy inhibitors chloroquine (CQ) or 3-methyladenine (3-MA), or the radical scavenger NAC.	3-methyladenine	229-233	uncoupling protein 2	Homo sapiens	54-58
23354080-7	2013	Inhibition of autophagy by 3-methyl-adenine (an inhibitor of class III phosphatidylinositol-3 kinase; 3-MA) reduced the cleavage of LC3 in T24 cells after baicalin treatment.	3-methyladenine	27-43	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	132-135
23663345-1	2013	OBJECTIVE: To explore the effects of 3-methyladenine (3-MA) and rapamycin (Rapa) on autophagy and uridine 5"-diphospho-glucuronosyltransferase 1A1 (UGT1A1) induced by sulforaphane (SFN) in human colon cancer Caco-2 cells.	3-methyladenine	54-58	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	98-146
23663345-6	2013	SFN-induced LC3-II protein could be attenuated and enhanced by 3-MA and Rapa respectively.	3-methyladenine	63-67	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	12-15
23258740-10	2013	Blocking autophagy using pharmacologic inhibitors (3-methyladenine, chloroquine, and bafilomycin A) or genetic inhibitors (siRNA targeting Atg3 and Atg7) enhanced cell death induced by Akt inhibitor AZD5363 in these tumor prostate cell lines.	3-methyladenine	51-66	AKT serine/threonine kinase 1	Homo sapiens	185-188
23404401-5	2013	Autophagy protects infected macrophages from pyroptosis, since caspase-1-dependent cell death occurred more frequently when autophagy was dampened pharmacologically by either 3-methyladenine or an inhibitor of the Atg4 protease.	3-methyladenine	175-190	caspase 1	Mus musculus	63-72
23135406-9	2013	Moreover, 3-methyladenine (3-MA), an autophagy inhibitor, attenuated evodiamine-induced autophagy through decreasing the conversion of LC3-I to LC3-II.	3-methyladenine	10-25	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	135-138
23135406-9	2013	Moreover, 3-methyladenine (3-MA), an autophagy inhibitor, attenuated evodiamine-induced autophagy through decreasing the conversion of LC3-I to LC3-II.	3-methyladenine	10-25	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	144-147
23135406-9	2013	Moreover, 3-methyladenine (3-MA), an autophagy inhibitor, attenuated evodiamine-induced autophagy through decreasing the conversion of LC3-I to LC3-II.	3-methyladenine	27-31	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	135-138
23135406-9	2013	Moreover, 3-methyladenine (3-MA), an autophagy inhibitor, attenuated evodiamine-induced autophagy through decreasing the conversion of LC3-I to LC3-II.	3-methyladenine	27-31	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	144-147
22817685-10	2013	Knockdown of adipose triglyceride lipase (ATGL) negated the stimulatory effect of 3-MA by &gt;90%, indicating that 3-MA enhanced ATGL-dependent hydrolysis of triacylglycerols.	3-methyladenine	82-86	patatin-like phospholipase domain containing 2	Mus musculus	13-40
22817685-10	2013	Knockdown of adipose triglyceride lipase (ATGL) negated the stimulatory effect of 3-MA by &gt;90%, indicating that 3-MA enhanced ATGL-dependent hydrolysis of triacylglycerols.	3-methyladenine	82-86	patatin-like phospholipase domain containing 2	Mus musculus	42-46
22817685-10	2013	Knockdown of adipose triglyceride lipase (ATGL) negated the stimulatory effect of 3-MA by &gt;90%, indicating that 3-MA enhanced ATGL-dependent hydrolysis of triacylglycerols.	3-methyladenine	82-86	patatin-like phospholipase domain containing 2	Mus musculus	129-133
22817685-10	2013	Knockdown of adipose triglyceride lipase (ATGL) negated the stimulatory effect of 3-MA by &gt;90%, indicating that 3-MA enhanced ATGL-dependent hydrolysis of triacylglycerols.	3-methyladenine	115-119	patatin-like phospholipase domain containing 2	Mus musculus	13-40
22817685-10	2013	Knockdown of adipose triglyceride lipase (ATGL) negated the stimulatory effect of 3-MA by &gt;90%, indicating that 3-MA enhanced ATGL-dependent hydrolysis of triacylglycerols.	3-methyladenine	115-119	patatin-like phospholipase domain containing 2	Mus musculus	42-46
22817685-10	2013	Knockdown of adipose triglyceride lipase (ATGL) negated the stimulatory effect of 3-MA by &gt;90%, indicating that 3-MA enhanced ATGL-dependent hydrolysis of triacylglycerols.	3-methyladenine	115-119	patatin-like phospholipase domain containing 2	Mus musculus	129-133
24454378-8	2013	Additionally, 3-MA selectively impaired the degradation of insoluble Mut-PrP, resulting in an increase in protease-resistant PrP, whereas the induction of autophagy by rapamycin reduced it.	3-methyladenine	14-18	prion protein	Mus musculus	73-76
24454378-8	2013	Additionally, 3-MA selectively impaired the degradation of insoluble Mut-PrP, resulting in an increase in protease-resistant PrP, whereas the induction of autophagy by rapamycin reduced it.	3-methyladenine	14-18	prion protein	Mus musculus	125-128
23372817-7	2013	Autophagic inhibitor 3-methyladenine (3-MA) decreased LC3-II levels, reduced the infarct volume, and mimicked some protective effect of 15d-PGJ(2) against cerebral I/R injury.	3-methyladenine	21-36	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	54-57
23372817-7	2013	Autophagic inhibitor 3-methyladenine (3-MA) decreased LC3-II levels, reduced the infarct volume, and mimicked some protective effect of 15d-PGJ(2) against cerebral I/R injury.	3-methyladenine	38-42	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	54-57
23109342-8	2012	Inhibition of RNase L-induced autophagy using Bafilomycin A1 or 3-methyladenine suppressed viral growth in initial stages; in later stages autophagy promoted viral replication dampening the antiviral effect.	3-methyladenine	64-79	ribonuclease L	Homo sapiens	14-21
22862962-6	2012	Inhibition of autophagy by 3-methyl-adenine (3-MA) reduced Beclin1 levels, inhibited IRS-1 Ser312 or GS Ser641 phosphorylation and decreased viral load.	3-methyladenine	27-43	beclin 1	Homo sapiens	59-66
22862962-6	2012	Inhibition of autophagy by 3-methyl-adenine (3-MA) reduced Beclin1 levels, inhibited IRS-1 Ser312 or GS Ser641 phosphorylation and decreased viral load.	3-methyladenine	45-49	beclin 1	Homo sapiens	59-66
22862962-6	2012	Inhibition of autophagy by 3-methyl-adenine (3-MA) reduced Beclin1 levels, inhibited IRS-1 Ser312 or GS Ser641 phosphorylation and decreased viral load.	3-methyladenine	45-49	insulin receptor substrate 1	Homo sapiens	85-90
22923157-3	2012	The apoptosis of prostate epithelial cancer cells LNCaP and PC3 was investigated upon treatment with the autophagy inhibitor 3-methyladenine and the autophagy inducer rapamycin, in combination with TNF-alpha.	3-methyladenine	125-140	chromobox 8	Homo sapiens	60-63
22923157-5	2012	TNF-alpha-induced apoptosis was potentiated by 3-methyladenine in the androgen-responsive LNCaP cells, whereas no effect was observed in the androgen-insensitive PC3 cells.	3-methyladenine	47-62	tumor necrosis factor	Homo sapiens	0-9
23302200-8	2012	The expression of p62 in cells treated with 3-MA showed a dose-dependent increase, while cyclinB1 showed a dose-dependent decrease.	3-methyladenine	44-48	nucleoporin 62	Homo sapiens	18-21
22898350-7	2012	The neuroprotective effects of DJ-1 were blocked by phosphoinositol 3-kinase and the autophagy inhibitor, 3-methyladenine, and by the ERK pathway inhibitor, U0126.	3-methyladenine	106-121	Parkinsonism associated deglycase	Rattus norvegicus	31-35
22972931-0	2012	Regulation of inflammatory response by 3-methyladenine involves the coordinative actions on Akt and glycogen synthase kinase 3beta rather than autophagy.	3-methyladenine	39-54	AKT serine/threonine kinase 1	Homo sapiens	92-95
22972931-0	2012	Regulation of inflammatory response by 3-methyladenine involves the coordinative actions on Akt and glycogen synthase kinase 3beta rather than autophagy.	3-methyladenine	39-54	glycogen synthase kinase 3 beta	Homo sapiens	100-130
22972931-3	2012	In this study, we aim to get a thorough understanding on the action mechanisms of 3-MA in TLR4-mediated inflammatory responses in RAW264.7 macrophages and, moreover, to decipher the action of 3-MA in modulation of autophagy.	3-methyladenine	82-86	toll like receptor 4	Homo sapiens	90-94
22972931-3	2012	In this study, we aim to get a thorough understanding on the action mechanisms of 3-MA in TLR4-mediated inflammatory responses in RAW264.7 macrophages and, moreover, to decipher the action of 3-MA in modulation of autophagy.	3-methyladenine	192-196	toll like receptor 4	Homo sapiens	90-94
22972931-4	2012	We found that 3-MA could enhance LPS-induced NF-kappaB activation and production of TNF-alpha, inducible NO synthase (iNOS), cyclooxygenase-2, IL-1beta, and IL-12.	3-methyladenine	14-18	tumor necrosis factor	Homo sapiens	84-93
22972931-4	2012	We found that 3-MA could enhance LPS-induced NF-kappaB activation and production of TNF-alpha, inducible NO synthase (iNOS), cyclooxygenase-2, IL-1beta, and IL-12.	3-methyladenine	14-18	nitric oxide synthase 2	Homo sapiens	95-116
22972931-4	2012	We found that 3-MA could enhance LPS-induced NF-kappaB activation and production of TNF-alpha, inducible NO synthase (iNOS), cyclooxygenase-2, IL-1beta, and IL-12.	3-methyladenine	14-18	nitric oxide synthase 2	Homo sapiens	118-122
22972931-4	2012	We found that 3-MA could enhance LPS-induced NF-kappaB activation and production of TNF-alpha, inducible NO synthase (iNOS), cyclooxygenase-2, IL-1beta, and IL-12.	3-methyladenine	14-18	prostaglandin-endoperoxide synthase 2	Homo sapiens	125-141
22972931-4	2012	We found that 3-MA could enhance LPS-induced NF-kappaB activation and production of TNF-alpha, inducible NO synthase (iNOS), cyclooxygenase-2, IL-1beta, and IL-12.	3-methyladenine	14-18	interleukin 1 beta	Homo sapiens	143-151
22972931-5	2012	In contrast, 3-MA suppressed LPS-induced IFN-beta production and STAT signaling.	3-methyladenine	13-17	interferon beta 1	Homo sapiens	41-49
22972931-6	2012	Studies revealed that 3-MA can, through inhibition of Akt as a result of class I PI3K interference, positively regulate p38, JNK, and p65, but negatively regulate TANK-binding kinase 1 and IFN regulatory factor 3 mediated by TLR4.	3-methyladenine	22-26	AKT serine/threonine kinase 1	Homo sapiens	54-57
22972931-6	2012	Studies revealed that 3-MA can, through inhibition of Akt as a result of class I PI3K interference, positively regulate p38, JNK, and p65, but negatively regulate TANK-binding kinase 1 and IFN regulatory factor 3 mediated by TLR4.	3-methyladenine	22-26	mitogen-activated protein kinase 14	Homo sapiens	120-123
22972931-6	2012	Studies revealed that 3-MA can, through inhibition of Akt as a result of class I PI3K interference, positively regulate p38, JNK, and p65, but negatively regulate TANK-binding kinase 1 and IFN regulatory factor 3 mediated by TLR4.	3-methyladenine	22-26	mitogen-activated protein kinase 8	Homo sapiens	125-128
22972931-6	2012	Studies revealed that 3-MA can, through inhibition of Akt as a result of class I PI3K interference, positively regulate p38, JNK, and p65, but negatively regulate TANK-binding kinase 1 and IFN regulatory factor 3 mediated by TLR4.	3-methyladenine	22-26	RELA proto-oncogene, NF-kB subunit	Homo sapiens	134-137
22972931-6	2012	Studies revealed that 3-MA can, through inhibition of Akt as a result of class I PI3K interference, positively regulate p38, JNK, and p65, but negatively regulate TANK-binding kinase 1 and IFN regulatory factor 3 mediated by TLR4.	3-methyladenine	22-26	TANK binding kinase 1	Homo sapiens	163-212
22972931-6	2012	Studies revealed that 3-MA can, through inhibition of Akt as a result of class I PI3K interference, positively regulate p38, JNK, and p65, but negatively regulate TANK-binding kinase 1 and IFN regulatory factor 3 mediated by TLR4.	3-methyladenine	22-26	toll like receptor 4	Homo sapiens	225-229
22972931-7	2012	As glycogen synthase kinase 3beta (GSK3beta) is an important Akt substrate, we further explored its involvement in the actions of 3-MA.	3-methyladenine	130-134	glycogen synthase kinase 3 beta	Homo sapiens	3-33
22972931-7	2012	As glycogen synthase kinase 3beta (GSK3beta) is an important Akt substrate, we further explored its involvement in the actions of 3-MA.	3-methyladenine	130-134	glycogen synthase kinase 3 beta	Homo sapiens	35-43
22972931-8	2012	3-MA was found to enhance LPS-induced NF-kappaB activation, iNOS, and pro-IL-1beta expression, and these actions were reversed by either GSK3beta inhibitors or small interfering GSK3beta.	3-methyladenine	0-4	nitric oxide synthase 2	Homo sapiens	60-64
22972931-8	2012	3-MA was found to enhance LPS-induced NF-kappaB activation, iNOS, and pro-IL-1beta expression, and these actions were reversed by either GSK3beta inhibitors or small interfering GSK3beta.	3-methyladenine	0-4	interleukin 1 beta	Homo sapiens	70-82
22972931-8	2012	3-MA was found to enhance LPS-induced NF-kappaB activation, iNOS, and pro-IL-1beta expression, and these actions were reversed by either GSK3beta inhibitors or small interfering GSK3beta.	3-methyladenine	0-4	glycogen synthase kinase 3 beta	Homo sapiens	137-145
22972931-8	2012	3-MA was found to enhance LPS-induced NF-kappaB activation, iNOS, and pro-IL-1beta expression, and these actions were reversed by either GSK3beta inhibitors or small interfering GSK3beta.	3-methyladenine	0-4	glycogen synthase kinase 3 beta	Homo sapiens	178-186
22972931-10	2012	These results not only shed new light on the action mechanisms of 3-MA to differentially regulate inflammatory outcomes derived from TLR4-mediated MyD88 and Toll/IL-1R domain-containing adapter inducing IFN-beta pathways, but also highlight the necessity to check autophagy status upon taking 3-MA as a general autophagy inhibitor.	3-methyladenine	66-70	toll like receptor 4	Homo sapiens	133-137
22972931-10	2012	These results not only shed new light on the action mechanisms of 3-MA to differentially regulate inflammatory outcomes derived from TLR4-mediated MyD88 and Toll/IL-1R domain-containing adapter inducing IFN-beta pathways, but also highlight the necessity to check autophagy status upon taking 3-MA as a general autophagy inhibitor.	3-methyladenine	66-70	MYD88 innate immune signal transduction adaptor	Homo sapiens	147-152
22972931-10	2012	These results not only shed new light on the action mechanisms of 3-MA to differentially regulate inflammatory outcomes derived from TLR4-mediated MyD88 and Toll/IL-1R domain-containing adapter inducing IFN-beta pathways, but also highlight the necessity to check autophagy status upon taking 3-MA as a general autophagy inhibitor.	3-methyladenine	66-70	toll like receptor 4	Homo sapiens	157-161
22972931-10	2012	These results not only shed new light on the action mechanisms of 3-MA to differentially regulate inflammatory outcomes derived from TLR4-mediated MyD88 and Toll/IL-1R domain-containing adapter inducing IFN-beta pathways, but also highlight the necessity to check autophagy status upon taking 3-MA as a general autophagy inhibitor.	3-methyladenine	66-70	interferon beta 1	Homo sapiens	203-211
22972933-2	2012	In this article, we show that inhibition of autophagy, either with the PI3K inhibitors 3-methyladenine, wortmannin, and LY294002 or with small interfering RNA against autophagy proteins augmented the secretion of IL-23 by human and mouse macrophages and dendritic cells in response to specific TLR agonists.	3-methyladenine	87-102	interleukin 23 subunit alpha	Homo sapiens	213-218
22972933-4	2012	Dendritic cells treated with LPS and 3-methyladenine secreted enhanced levels of both IL-1beta and IL-23, and supernatants from these cells stimulated the innate secretion of IL-17, IFN-gamma, and IL-22 by gammadelta T cells.	3-methyladenine	37-52	interleukin 1 beta	Homo sapiens	86-94
22972933-4	2012	Dendritic cells treated with LPS and 3-methyladenine secreted enhanced levels of both IL-1beta and IL-23, and supernatants from these cells stimulated the innate secretion of IL-17, IFN-gamma, and IL-22 by gammadelta T cells.	3-methyladenine	37-52	interleukin 23 subunit alpha	Homo sapiens	99-104
22972933-4	2012	Dendritic cells treated with LPS and 3-methyladenine secreted enhanced levels of both IL-1beta and IL-23, and supernatants from these cells stimulated the innate secretion of IL-17, IFN-gamma, and IL-22 by gammadelta T cells.	3-methyladenine	37-52	interleukin 17A	Homo sapiens	175-180
22972933-4	2012	Dendritic cells treated with LPS and 3-methyladenine secreted enhanced levels of both IL-1beta and IL-23, and supernatants from these cells stimulated the innate secretion of IL-17, IFN-gamma, and IL-22 by gammadelta T cells.	3-methyladenine	37-52	interferon gamma	Homo sapiens	182-191
22972933-4	2012	Dendritic cells treated with LPS and 3-methyladenine secreted enhanced levels of both IL-1beta and IL-23, and supernatants from these cells stimulated the innate secretion of IL-17, IFN-gamma, and IL-22 by gammadelta T cells.	3-methyladenine	37-52	interleukin 22	Homo sapiens	197-202
22638980-0	2012	Differential effects of the autophagy inhibitors 3-methyladenine and chloroquine on spontaneous and TNF-alpha-induced neutrophil apoptosis.	3-methyladenine	49-64	tumor necrosis factor	Homo sapiens	100-109
22638980-4	2012	We first showed that the established autophagy inhibitors 3-methyladenine (MA) and chloroquine (CQ) markedly accelerated spontaneous neutrophil apoptosis as was evidenced by phosphatidylserine exposure, DNA fragmentation and caspase-3 activation.	3-methyladenine	58-73	caspase 3	Homo sapiens	225-234
22824846-4	2012	The inhibition of autophagy by knocking down beclin-1 or by using autophagy inhibitors, such as 3-methyladenine, bafilomycin A and chloroquine significantly enhanced IBC-induced cell death, as demonstrated by the increased number of Annexin V-positive cells.	3-methyladenine	96-111	annexin A5	Homo sapiens	233-242
22819980-5	2012	Inhibition of macroautophagy by administration of 3-methyladenine enhanced the binge ethanol hepatotoxicity, steatosis and oxidant stress in CYP2E1 KI, but not CYP2E1 KO mice.	3-methyladenine	50-65	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	141-147
22932192-14	2012	The 3-MA group induced a slight increase in the Cav1.3 levels within 15 minutes, but significantly attenuated the Cav1.3 levels after 30 minutes.	3-methyladenine	4-8	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	48-54
22932192-14	2012	The 3-MA group induced a slight increase in the Cav1.3 levels within 15 minutes, but significantly attenuated the Cav1.3 levels after 30 minutes.	3-methyladenine	4-8	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	114-120
22736198-10	2012	Both 3-MA and NEC-1 suppressed TBI-induced caspase-3 activation and LC3-II formation, Z-VAD only inhibited caspase-3 activation but increased LC3-II expression at 24 h post-TBI.	3-methyladenine	5-9	caspase 3	Mus musculus	43-52
22736198-10	2012	Both 3-MA and NEC-1 suppressed TBI-induced caspase-3 activation and LC3-II formation, Z-VAD only inhibited caspase-3 activation but increased LC3-II expression at 24 h post-TBI.	3-methyladenine	5-9	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	68-71
22281705-7	2012	In these same cells, the autophagy inhibitor 3-methyladenine rescued TGF-beta1 effect on both autophagy and myogenesis, indicating that PED/PEA-15 mediates TGF-beta1 effects in muscle.	3-methyladenine	45-60	transforming growth factor, beta 1	Mus musculus	69-78
22281705-7	2012	In these same cells, the autophagy inhibitor 3-methyladenine rescued TGF-beta1 effect on both autophagy and myogenesis, indicating that PED/PEA-15 mediates TGF-beta1 effects in muscle.	3-methyladenine	45-60	preimplantation embryo development	Mus musculus	136-139
22281705-7	2012	In these same cells, the autophagy inhibitor 3-methyladenine rescued TGF-beta1 effect on both autophagy and myogenesis, indicating that PED/PEA-15 mediates TGF-beta1 effects in muscle.	3-methyladenine	45-60	proliferation and apoptosis adaptor protein 15A	Mus musculus	140-146
22281705-7	2012	In these same cells, the autophagy inhibitor 3-methyladenine rescued TGF-beta1 effect on both autophagy and myogenesis, indicating that PED/PEA-15 mediates TGF-beta1 effects in muscle.	3-methyladenine	45-60	transforming growth factor, beta 1	Mus musculus	156-165
22543707-8	2012	Treatment with the autophagy inhibitor 3-MA or the proteasome inhibitors lactacystin and MG-132 increased Htt552 levels in PC12 cells infected with Ad-Htt-18Q-552 or Ad-Htt-100Q-552.	3-methyladenine	39-43	huntingtin	Rattus norvegicus	106-109
22543707-8	2012	Treatment with the autophagy inhibitor 3-MA or the proteasome inhibitors lactacystin and MG-132 increased Htt552 levels in PC12 cells infected with Ad-Htt-18Q-552 or Ad-Htt-100Q-552.	3-methyladenine	39-43	huntingtin	Rattus norvegicus	151-154
22433868-7	2012	3-methyl-adenine (3-MA), an inhibitor of phosphatidyl inositol 3-kinase (PI3-kinase) prevented induction of ATG5 and activation of LC3-II and blocked autophagosome formation.	3-methyladenine	0-16	autophagy related 5	Homo sapiens	108-112
22433868-7	2012	3-methyl-adenine (3-MA), an inhibitor of phosphatidyl inositol 3-kinase (PI3-kinase) prevented induction of ATG5 and activation of LC3-II and blocked autophagosome formation.	3-methyladenine	18-22	autophagy related 5	Homo sapiens	108-112
22433868-8	2012	3-MA also blocked induction of GRP78 and CHOP, suggesting that PI3-kinase, which is known to mediate ER stress-induced autophagy, also plays a role in initiating apoptosis in response to ER stress.	3-methyladenine	0-4	heat shock protein family A (Hsp70) member 5	Homo sapiens	31-36
22433868-8	2012	3-MA also blocked induction of GRP78 and CHOP, suggesting that PI3-kinase, which is known to mediate ER stress-induced autophagy, also plays a role in initiating apoptosis in response to ER stress.	3-methyladenine	0-4	DNA damage inducible transcript 3	Homo sapiens	41-45
22322529-11	2012	Similarly, when             autophagy was prevented at an early stage by application of 3-methyladenine, the             pro-apoptotic effects of TGF-beta1 were attenuated.	3-methyladenine	88-103	transforming growth factor beta 1	Homo sapiens	146-155
22367117-12	2012	Evodiamine-induced autophagy is partially involved in             the death of SGC-7901 cells which was confirmed by using the autophagy inhibitor             3-methyladenine (3-MA).	3-methyladenine	159-174	sarcoglycan beta	Homo sapiens	79-82
22367117-12	2012	Evodiamine-induced autophagy is partially involved in             the death of SGC-7901 cells which was confirmed by using the autophagy inhibitor             3-methyladenine (3-MA).	3-methyladenine	176-180	sarcoglycan beta	Homo sapiens	79-82
22540380-6	2012	The presence of 3-methyladenine (as selective autophagy inhibitor) increased the antineoplastic effect of Cas III-ia, while Z-VAD-FMK only showed partial protection from the antineoplastic effect induced by Cas III-ia, and ROS antioxidants (N-acetylcysteine) decreased apoptosis, autophagy and JNK activity.	3-methyladenine	16-31	mitogen-activated protein kinase 8	Homo sapiens	294-297
22396599-10	2012	Pretreatment of pDCs with 3-MA significantly reduced the induction of IFN-alpha by ssRNA40.	3-methyladenine	26-30	interferon alpha 1	Homo sapiens	70-79
22218562-6	2012	Inhibition of Res-induced autophagy by the autophagy inhibitor 3-methyladenine caused a significant decrease in apoptosis accompanied by decreased cleavage of Casapse-8 and Caspase-3, indicating that Res-induced autophagy was cytotoxic.	3-methyladenine	63-78	caspase 3	Homo sapiens	173-182
22209892-4	2012	Indeed, resveratrol, 3-methyladenine (3-MA), and a short hairpin RNA directed against autophagy gene beclin 1 (shBCN1) each was able to attenuate DOX-induced autophagy and cardiomyocyte death, but resveratrol did not provide additional protection in the presence of 3-MA or shBCN1.	3-methyladenine	266-270	beclin 1	Homo sapiens	101-109
22227332-8	2012	In accordance with these results, the treatment of EAT cells with 3 methyladenine (3-MA), an autophagy inhibitor; significantly increased the number of apoptotic cells after NTS1 treatment, suggesting that pharmacological modulation of autophagy augments the NTS1 efficacy.	3-methyladenine	66-81	neurotensin	Mus musculus	174-178
22227332-8	2012	In accordance with these results, the treatment of EAT cells with 3 methyladenine (3-MA), an autophagy inhibitor; significantly increased the number of apoptotic cells after NTS1 treatment, suggesting that pharmacological modulation of autophagy augments the NTS1 efficacy.	3-methyladenine	66-81	neurotensin	Mus musculus	259-263
22227332-8	2012	In accordance with these results, the treatment of EAT cells with 3 methyladenine (3-MA), an autophagy inhibitor; significantly increased the number of apoptotic cells after NTS1 treatment, suggesting that pharmacological modulation of autophagy augments the NTS1 efficacy.	3-methyladenine	83-87	neurotensin	Mus musculus	174-178
22227332-8	2012	In accordance with these results, the treatment of EAT cells with 3 methyladenine (3-MA), an autophagy inhibitor; significantly increased the number of apoptotic cells after NTS1 treatment, suggesting that pharmacological modulation of autophagy augments the NTS1 efficacy.	3-methyladenine	83-87	neurotensin	Mus musculus	259-263
22266730-9	2012	Treatment with the autophagy inhibitor 3-MA (10 mmol/L) significantly increased the accumulation of mutant Htt-552, and reduced the expression of GLT-1 and [(3)H]glutamate uptake in the astrocytes.	3-methyladenine	39-43	huntingtin	Rattus norvegicus	107-110
22266730-9	2012	Treatment with the autophagy inhibitor 3-MA (10 mmol/L) significantly increased the accumulation of mutant Htt-552, and reduced the expression of GLT-1 and [(3)H]glutamate uptake in the astrocytes.	3-methyladenine	39-43	solute carrier family 1 member 2	Rattus norvegicus	146-151
22190546-10	2012	Furthermore, autophagy inhibitor 3-methyladenine reversed the increase of beclin 1 mRNA.	3-methyladenine	33-48	beclin 1	Homo sapiens	74-82
21915620-7	2012	Inhibition of autophagy by 3-methyladenine (3-MA) facilitated apoptosis and caspase3 activation at 6, 12, and 18 h but made no effect at 24 or 48 h. Sirt1 protein level in nuclei was gradually enhanced along with the increase of autophagy, however, 3-MA suppressed this enhancement.	3-methyladenine	27-42	caspase 3	Homo sapiens	76-84
21915620-7	2012	Inhibition of autophagy by 3-methyladenine (3-MA) facilitated apoptosis and caspase3 activation at 6, 12, and 18 h but made no effect at 24 or 48 h. Sirt1 protein level in nuclei was gradually enhanced along with the increase of autophagy, however, 3-MA suppressed this enhancement.	3-methyladenine	27-42	sirtuin 1	Homo sapiens	149-154
21915620-7	2012	Inhibition of autophagy by 3-methyladenine (3-MA) facilitated apoptosis and caspase3 activation at 6, 12, and 18 h but made no effect at 24 or 48 h. Sirt1 protein level in nuclei was gradually enhanced along with the increase of autophagy, however, 3-MA suppressed this enhancement.	3-methyladenine	44-48	caspase 3	Homo sapiens	76-84
21915620-7	2012	Inhibition of autophagy by 3-methyladenine (3-MA) facilitated apoptosis and caspase3 activation at 6, 12, and 18 h but made no effect at 24 or 48 h. Sirt1 protein level in nuclei was gradually enhanced along with the increase of autophagy, however, 3-MA suppressed this enhancement.	3-methyladenine	44-48	sirtuin 1	Homo sapiens	149-154
21915620-7	2012	Inhibition of autophagy by 3-methyladenine (3-MA) facilitated apoptosis and caspase3 activation at 6, 12, and 18 h but made no effect at 24 or 48 h. Sirt1 protein level in nuclei was gradually enhanced along with the increase of autophagy, however, 3-MA suppressed this enhancement.	3-methyladenine	249-253	sirtuin 1	Homo sapiens	149-154
22361585-7	2012	3-MA, at the dose blocking autophagy, significantly inhibited IPC-induced HSP70, HSP60 and GRP78 upregulation; meanwhile, it also aggregated the ER stress and increased activated caspase-12, caspase-3 and CHOP protein levels both in vitro and in vivo models.	3-methyladenine	0-4	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	74-79
22361585-7	2012	3-MA, at the dose blocking autophagy, significantly inhibited IPC-induced HSP70, HSP60 and GRP78 upregulation; meanwhile, it also aggregated the ER stress and increased activated caspase-12, caspase-3 and CHOP protein levels both in vitro and in vivo models.	3-methyladenine	0-4	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	81-86
22361585-7	2012	3-MA, at the dose blocking autophagy, significantly inhibited IPC-induced HSP70, HSP60 and GRP78 upregulation; meanwhile, it also aggregated the ER stress and increased activated caspase-12, caspase-3 and CHOP protein levels both in vitro and in vivo models.	3-methyladenine	0-4	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	91-96
22361585-7	2012	3-MA, at the dose blocking autophagy, significantly inhibited IPC-induced HSP70, HSP60 and GRP78 upregulation; meanwhile, it also aggregated the ER stress and increased activated caspase-12, caspase-3 and CHOP protein levels both in vitro and in vivo models.	3-methyladenine	0-4	caspase 12	Rattus norvegicus	179-189
22361585-7	2012	3-MA, at the dose blocking autophagy, significantly inhibited IPC-induced HSP70, HSP60 and GRP78 upregulation; meanwhile, it also aggregated the ER stress and increased activated caspase-12, caspase-3 and CHOP protein levels both in vitro and in vivo models.	3-methyladenine	0-4	caspase 3	Rattus norvegicus	191-200
22361585-7	2012	3-MA, at the dose blocking autophagy, significantly inhibited IPC-induced HSP70, HSP60 and GRP78 upregulation; meanwhile, it also aggregated the ER stress and increased activated caspase-12, caspase-3 and CHOP protein levels both in vitro and in vivo models.	3-methyladenine	0-4	DNA-damage inducible transcript 3	Rattus norvegicus	205-209
22297293-6	2012	3-methyladenine attenuated JNK signaling and significantly decreased BNIP3 expression and reversed cardiac remodeling in heart failure.	3-methyladenine	0-15	mitogen-activated protein kinase 8	Rattus norvegicus	27-30
22297293-6	2012	3-methyladenine attenuated JNK signaling and significantly decreased BNIP3 expression and reversed cardiac remodeling in heart failure.	3-methyladenine	0-15	BCL2 interacting protein 3	Rattus norvegicus	69-74
22155150-7	2012	Autophagic inhibitor 3-methyladenine (3-MA) decreased phagocytosis and the expression of ERK whereas increased the expression of NF-kappaB- and caspase-1-mediated IL-1beta release.	3-methyladenine	21-36	mitogen-activated protein kinase 1	Homo sapiens	89-92
22155150-7	2012	Autophagic inhibitor 3-methyladenine (3-MA) decreased phagocytosis and the expression of ERK whereas increased the expression of NF-kappaB- and caspase-1-mediated IL-1beta release.	3-methyladenine	21-36	nuclear factor kappa B subunit 1	Homo sapiens	129-138
22155150-7	2012	Autophagic inhibitor 3-methyladenine (3-MA) decreased phagocytosis and the expression of ERK whereas increased the expression of NF-kappaB- and caspase-1-mediated IL-1beta release.	3-methyladenine	21-36	caspase 1	Homo sapiens	144-153
22155150-7	2012	Autophagic inhibitor 3-methyladenine (3-MA) decreased phagocytosis and the expression of ERK whereas increased the expression of NF-kappaB- and caspase-1-mediated IL-1beta release.	3-methyladenine	21-36	interleukin 1 beta	Homo sapiens	163-171
22155150-7	2012	Autophagic inhibitor 3-methyladenine (3-MA) decreased phagocytosis and the expression of ERK whereas increased the expression of NF-kappaB- and caspase-1-mediated IL-1beta release.	3-methyladenine	38-42	mitogen-activated protein kinase 1	Homo sapiens	89-92
22155150-7	2012	Autophagic inhibitor 3-methyladenine (3-MA) decreased phagocytosis and the expression of ERK whereas increased the expression of NF-kappaB- and caspase-1-mediated IL-1beta release.	3-methyladenine	38-42	nuclear factor kappa B subunit 1	Homo sapiens	129-138
22155150-7	2012	Autophagic inhibitor 3-methyladenine (3-MA) decreased phagocytosis and the expression of ERK whereas increased the expression of NF-kappaB- and caspase-1-mediated IL-1beta release.	3-methyladenine	38-42	caspase 1	Homo sapiens	144-153
22155150-7	2012	Autophagic inhibitor 3-methyladenine (3-MA) decreased phagocytosis and the expression of ERK whereas increased the expression of NF-kappaB- and caspase-1-mediated IL-1beta release.	3-methyladenine	38-42	interleukin 1 beta	Homo sapiens	163-171
22222116-7	2012	Knockdown of Beclin 1 by either RNA interference or co-treatment with the autophagy inhibitor, 3-methyladenine(3-MA), significantly enhanced the melatonin-induced apoptosis in mouse hepatoma H22 cells.	3-methyladenine	95-110	beclin 1, autophagy related	Mus musculus	13-21
22222116-7	2012	Knockdown of Beclin 1 by either RNA interference or co-treatment with the autophagy inhibitor, 3-methyladenine(3-MA), significantly enhanced the melatonin-induced apoptosis in mouse hepatoma H22 cells.	3-methyladenine	111-115	beclin 1, autophagy related	Mus musculus	13-21
21950964-7	2012	Furthermore, the inhibition of autophagy with 3-methyladenine significantly reduced the thalamic neuronal damage, beta-amyloid deposits, and beta-site APP-cleaving enzyme 1 activity.	3-methyladenine	46-61	beta-secretase 1	Rattus norvegicus	141-172
21864037-5	2012	While the use of autophagy inhibitor, 3-methyladenine (3-MA), blocked the autophagic reaction and increased leukemia cell sensitivity to chemotherapy, enhancing HMGB1 expression decreased this sensitivity.	3-methyladenine	38-53	high mobility group box 1	Homo sapiens	161-166
21946213-4	2012	The induction of autophagy by rapamycin increased viral production, whereas the inhibition of autophagy by 3-methyladenine reduced viral yields for both RP-9 and RP-2ms.	3-methyladenine	107-122	RP9 pre-mRNA splicing factor	Homo sapiens	153-157
22158107-14	2012	The inhibition of autophagy by 3-MA (5 mmol/L) sensitized the cells to oridonin-induced apoptosis, which was accompanied by increased intracellular ROS and decreased SIRT1.	3-methyladenine	31-35	sirtuin 1	Homo sapiens	166-171
22062220-8	2012	In contrast, inhibition of autophagy by 3-methyladenine reversed the proresolving and antifibrotic roles of TLR4 agonists and increased animal death.	3-methyladenine	40-55	toll-like receptor 4	Mus musculus	108-112
21956714-6	2012	The ISL-mediated autophagic and apoptotic cell death were obviously attenuated by transfection with dominant negative Atg5 (DN-Atg5(K130R)) plasmids or treatment with 3-methyladenine(3-MA).	3-methyladenine	167-182	autophagy related 5	Homo sapiens	127-131
22113203-8	2012	At the early stage of OGD, autophagy inducer rapamycin protected against neuronal injury induced by Nampt knockdown, whereas autophagy inhibitor 3-methyladenine abolished the neuroprotective effect of Nampt partly.	3-methyladenine	145-160	nicotinamide phosphoribosyltransferase	Homo sapiens	201-206
22745580-12	2012	Autophagy inhibitor 3-methyladenine (3-MA) reduced AVOs formation and inhibited LC3-I to LC3-II conversion.	3-methyladenine	20-35	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	80-83
22745580-12	2012	Autophagy inhibitor 3-methyladenine (3-MA) reduced AVOs formation and inhibited LC3-I to LC3-II conversion.	3-methyladenine	20-35	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	89-92
22745580-12	2012	Autophagy inhibitor 3-methyladenine (3-MA) reduced AVOs formation and inhibited LC3-I to LC3-II conversion.	3-methyladenine	37-41	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	80-83
22745580-12	2012	Autophagy inhibitor 3-methyladenine (3-MA) reduced AVOs formation and inhibited LC3-I to LC3-II conversion.	3-methyladenine	37-41	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	89-92
21728063-7	2012	Conversely, 3-MA decreased expression of LC3 and beclin-1, increased the average value of brain edema and BBB disfunction, and aggravated neurological deficits.	3-methyladenine	12-16	beclin 1	Rattus norvegicus	49-57
22785354-5	2012	The mRNA expression of Gdf9, c-mos and cyclin B maintained high levels in 2C and 4-cell (4C) embryos treated with 3-MA compared with the control.	3-methyladenine	114-118	growth differentiation factor 9	Sus scrofa	23-27
22785354-5	2012	The mRNA expression of Gdf9, c-mos and cyclin B maintained high levels in 2C and 4-cell (4C) embryos treated with 3-MA compared with the control.	3-methyladenine	114-118	MOS proto-oncogene, serine/threonine kinase	Sus scrofa	29-34
22785354-5	2012	The mRNA expression of Gdf9, c-mos and cyclin B maintained high levels in 2C and 4-cell (4C) embryos treated with 3-MA compared with the control.	3-methyladenine	114-118	cyclin B1	Sus scrofa	39-47
22785354-11	2012	Finally, blastocysts derived following treatment with 3-MA or rapamycin exhibited significantly decreased expression of selected transcription factors, including Pou5f1, Sox2 and Nanog.	3-methyladenine	54-58	POU domain, class 5, transcription factor 1	Sus scrofa	162-168
22785354-11	2012	Finally, blastocysts derived following treatment with 3-MA or rapamycin exhibited significantly decreased expression of selected transcription factors, including Pou5f1, Sox2 and Nanog.	3-methyladenine	54-58	transcription factor SOX-2	Sus scrofa	170-174
22785354-11	2012	Finally, blastocysts derived following treatment with 3-MA or rapamycin exhibited significantly decreased expression of selected transcription factors, including Pou5f1, Sox2 and Nanog.	3-methyladenine	54-58	homeobox protein NANOG	Sus scrofa	179-184
23029398-10	2012	Conversely, autophagy inhibitor 3-methyladenine (3-MA) attenuated the ischemic insults, inhibited the activation of autophagy, and elevated the expression of anti-apoptotic protein Bcl-2, to an extent comparable to IPOC.	3-methyladenine	32-47	BCL2, apoptosis regulator	Rattus norvegicus	181-186
23029398-10	2012	Conversely, autophagy inhibitor 3-methyladenine (3-MA) attenuated the ischemic insults, inhibited the activation of autophagy, and elevated the expression of anti-apoptotic protein Bcl-2, to an extent comparable to IPOC.	3-methyladenine	49-53	BCL2, apoptosis regulator	Rattus norvegicus	181-186
21990425-9	2011	Autophagy inhibition by 3"-methyladenine, LY294002, wortmannin or by knockdown of Beclin-1 or Atg 7 inhibited MCPIP-induced expression of OC markers.	3-methyladenine	24-40	zinc finger CCCH-type containing 12A	Homo sapiens	110-115
21788101-5	2011	The downregulation of Beclin 1 or 3-methyladenine treatment suppressed adeno-XAF1-induced autophagy, but significantly enhanced adeno-XAF1-induced apoptosis.	3-methyladenine	34-49	XIAP associated factor 1	Homo sapiens	77-81
21788101-5	2011	The downregulation of Beclin 1 or 3-methyladenine treatment suppressed adeno-XAF1-induced autophagy, but significantly enhanced adeno-XAF1-induced apoptosis.	3-methyladenine	34-49	XIAP associated factor 1	Homo sapiens	134-138
22015349-8	2011	3-MA inhibited thrombin-induced autophagic vacuole formation and exacerbated thrombin-induced cell death.	3-methyladenine	0-4	coagulation factor II, thrombin	Homo sapiens	15-23
22015349-8	2011	3-MA inhibited thrombin-induced autophagic vacuole formation and exacerbated thrombin-induced cell death.	3-methyladenine	0-4	coagulation factor II, thrombin	Homo sapiens	77-85
22020078-5	2011	Starvation-induced cell death was greatly increased in HBX-expressing cell lines treated either with the autophagy inhibitor 3-methyladenine (3-MA) or with an siRNA directed against an autophagy gene, beclin 1.	3-methyladenine	125-140	X protein	Hepatitis B virus	55-58
22020078-5	2011	Starvation-induced cell death was greatly increased in HBX-expressing cell lines treated either with the autophagy inhibitor 3-methyladenine (3-MA) or with an siRNA directed against an autophagy gene, beclin 1.	3-methyladenine	142-146	X protein	Hepatitis B virus	55-58
20838925-0	2011	Acute phase expression pattern of ZnTs, LC3, and beclin-1 in rat Hippocampus and its regulation by 3-methyladenine following recurrent neonatal seizures.	3-methyladenine	99-114	beclin 1	Rattus norvegicus	49-57
20838925-3	2011	The present study sought to investigate the contribution of an autophagy inhibitor (3-methyladenine, 3-MA) on the regulation of ZnTs, microtubule-associated protein 1A/1B light chain 3 (LC3), and beclin-1 expression in rat hippocampus following recurrent neonatal seizures.	3-methyladenine	84-99	microtubule-associated protein 1A	Rattus norvegicus	134-170
20838925-3	2011	The present study sought to investigate the contribution of an autophagy inhibitor (3-methyladenine, 3-MA) on the regulation of ZnTs, microtubule-associated protein 1A/1B light chain 3 (LC3), and beclin-1 expression in rat hippocampus following recurrent neonatal seizures.	3-methyladenine	84-99	beclin 1	Rattus norvegicus	196-204
20838925-3	2011	The present study sought to investigate the contribution of an autophagy inhibitor (3-methyladenine, 3-MA) on the regulation of ZnTs, microtubule-associated protein 1A/1B light chain 3 (LC3), and beclin-1 expression in rat hippocampus following recurrent neonatal seizures.	3-methyladenine	101-105	microtubule-associated protein 1A	Rattus norvegicus	134-170
20838925-3	2011	The present study sought to investigate the contribution of an autophagy inhibitor (3-methyladenine, 3-MA) on the regulation of ZnTs, microtubule-associated protein 1A/1B light chain 3 (LC3), and beclin-1 expression in rat hippocampus following recurrent neonatal seizures.	3-methyladenine	101-105	beclin 1	Rattus norvegicus	196-204
20838925-6	2011	Pretreatment with 3-MA remarkably attenuated seizure-induced ZnT-1, ZnT-2, LC3, and beclin-1 increase.	3-methyladenine	18-22	solute carrier family 30 member 1	Rattus norvegicus	61-66
20838925-6	2011	Pretreatment with 3-MA remarkably attenuated seizure-induced ZnT-1, ZnT-2, LC3, and beclin-1 increase.	3-methyladenine	18-22	solute carrier family 30 member 2	Rattus norvegicus	68-73
20838925-6	2011	Pretreatment with 3-MA remarkably attenuated seizure-induced ZnT-1, ZnT-2, LC3, and beclin-1 increase.	3-methyladenine	18-22	beclin 1	Rattus norvegicus	84-92
21610319-2	2011	Full-length (45 kDa) endogenous BHMT was found to be cleaved in an autophagy-dependent (3-methyladenine-sensitive) manner in isolated rat hepatocytes to generate a novel N-terminal 10-kDa fragment (p10) identified and characterized by mass spectrometry.	3-methyladenine	88-103	betaine-homocysteine S-methyltransferase	Rattus norvegicus	32-36
21406388-5	2011	DESIGN AND SETTING: Peripheral blood mononuclear cells from healthy individuals and patients with Crohn"s disease with different ATG16L1 genotypes were stimulated with ligands for Toll-like receptor 2 (TLR2), TLR4 and nucleotide-binding oligomerisation domain 2 (NOD2), with or without the autophagy inhibitor 3-methyladenine.	3-methyladenine	310-325	toll like receptor 2	Homo sapiens	180-200
21072519-7	2011	Pretreatment with vitamin E, a ROS scavenger, and 3-methyladenine, an autophagy inhibitor, individually led to decreased sensitivity to 4-HPR; however, the de novo ceramide inhibitor myriocin had no effect.	3-methyladenine	50-65	haptoglobin-related protein	Homo sapiens	138-141
21166739-8	2011	Compared with radiation alone, 3-MA combined with radiation significantly decreased cell viability, as well as autophagic ratio, beclin-1, and LC3-II protein level.	3-methyladenine	31-35	beclin 1	Homo sapiens	129-137
21166739-8	2011	Compared with radiation alone, 3-MA combined with radiation significantly decreased cell viability, as well as autophagic ratio, beclin-1, and LC3-II protein level.	3-methyladenine	31-35	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	143-146
21684529-7	2011	3-MA suppressed the increases in LC3-II and Beclin 1 induced by HBO preconditioning and attenuated the neuroprotection of HBO preconditioning against cerebral ischemia.	3-methyladenine	0-4	beclin 1	Rattus norvegicus	44-52
21453691-6	2011	Application of IR with 3-MA to inhibit autophagy simultaneously suppressed the expression of LC3 and enhanced cell death.	3-methyladenine	23-27	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	93-96
21681844-9	2011	Interestingly, the inner cell mass, detected by immunostaining with POU5F1 (OCT3/4) after 3-MA or rapamycin treatment of embryos, was significantly increased compared to controls.	3-methyladenine	90-94	POU domain, class 5, transcription factor 1	Mus musculus	68-74
21463664-7	2011	Immunoblotting analysis showed that 3-MA pretreatment reduced post-TBI Beclin-1 and LC3-II levels, and maintained p62/SQSTM1 (p62) levels.	3-methyladenine	36-40	beclin 1, autophagy related	Mus musculus	71-79
21463664-7	2011	Immunoblotting analysis showed that 3-MA pretreatment reduced post-TBI Beclin-1 and LC3-II levels, and maintained p62/SQSTM1 (p62) levels.	3-methyladenine	36-40	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	84-87
21463664-7	2011	Immunoblotting analysis showed that 3-MA pretreatment reduced post-TBI Beclin-1 and LC3-II levels, and maintained p62/SQSTM1 (p62) levels.	3-methyladenine	36-40	sequestosome 1	Mus musculus	114-117
21463664-7	2011	Immunoblotting analysis showed that 3-MA pretreatment reduced post-TBI Beclin-1 and LC3-II levels, and maintained p62/SQSTM1 (p62) levels.	3-methyladenine	36-40	sequestosome 1	Mus musculus	118-124
21463664-7	2011	Immunoblotting analysis showed that 3-MA pretreatment reduced post-TBI Beclin-1 and LC3-II levels, and maintained p62/SQSTM1 (p62) levels.	3-methyladenine	36-40	sequestosome 1	Mus musculus	126-129
21463664-8	2011	In addition, double immunolabeling showed that the increased punctate LC3-II dots colocalizing with Propidium Iodide (PI)-stained nuclei at 24 h after injury, were partially inhibited by 3-MA pretreatment.	3-methyladenine	187-191	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	70-73
21421874-6	2011	Detached retinas had increased levels of autophagosome-associated lysosomal proteases, cathepsins B and D. Inhibition of autophagy by 3-MA or siAtg5 accelerated the time course of caspase 8 activation and photoreceptor TUNEL staining.	3-methyladenine	134-138	caspase 8	Rattus norvegicus	180-189
21220021-5	2011	Addition of 3-methyladenine or small-interfering RNA against autophagy-related gene 6 (ATG6/Beclin-1) blocked clioquinol-induced increases in LC3-II.	3-methyladenine	12-27	beclin 1	Homo sapiens	87-91
21262221-6	2011	Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy.	3-methyladenine	30-45	tumor protein p53	Homo sapiens	90-93
21262221-6	2011	Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy.	3-methyladenine	30-45	nuclear factor kappa B subunit 1	Homo sapiens	117-126
21262221-6	2011	Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy.	3-methyladenine	30-45	tumor protein p53	Homo sapiens	198-201
21262221-6	2011	Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy.	3-methyladenine	30-45	nuclear factor kappa B subunit 1	Homo sapiens	222-231
21262221-6	2011	Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy.	3-methyladenine	47-51	tumor protein p53	Homo sapiens	90-93
21262221-6	2011	Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy.	3-methyladenine	47-51	nuclear factor kappa B subunit 1	Homo sapiens	117-126
21262221-6	2011	Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy.	3-methyladenine	47-51	tumor protein p53	Homo sapiens	198-201
21262221-6	2011	Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy.	3-methyladenine	47-51	nuclear factor kappa B subunit 1	Homo sapiens	222-231
21262221-7	2011	In addition, we also found that 3-MA efficiently abrogated silibinin"s cyto-protective effect against mitomycin C-induced cell death, and reversed the suppressive efficacy of silibinin on p53 expression, suggesting that autophagy contributed to silibinin"s cyto-protective effect against mitomycin C-induced cell death in A375-S2 cells.	3-methyladenine	32-36	tumor protein p53	Homo sapiens	188-191
21299716-4	2011	The latter effect of adiponectin in glucose deprivation was significantly inhibited by adding autophagy inhibitors, chloroquine, 3-methyl adenine or a combination of pepstatin A and E-64d, suggesting that the effect of supporting cell growth was dependent, at least in part, on the induction of autophagy.	3-methyladenine	129-145	adiponectin, C1Q and collagen domain containing	Homo sapiens	21-32
21187718-4	2011	Inhibition of autophagy by short hairpin (sh) RNA that target essential autophagy genes such as Atg1, Atg5 and PI3KC3 and by autophagy inhibitors (e.g. 3-methyladenine), blocked PML-RARalpha degradation and subsequently granulocytic differentiation of human myeloid leukemic cells.	3-methyladenine	152-167	PML nuclear body scaffold	Homo sapiens	178-181
21412169-0	2011	Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: a widely used inhibitor of autophagy.	3-methyladenine	110-125	carbonic anhydrase 1	Rattus norvegicus	75-78
21412169-7	2011	The redistribution of the lysosomal enzyme cathepsin B after injury was inhibited by 3-MA administered before ischemia, suggesting that this might be another important mechanism for the protective effect of 3-MA in ischemic neuronal injury.	3-methyladenine	85-89	cathepsin B	Rattus norvegicus	43-54
21412169-7	2011	The redistribution of the lysosomal enzyme cathepsin B after injury was inhibited by 3-MA administered before ischemia, suggesting that this might be another important mechanism for the protective effect of 3-MA in ischemic neuronal injury.	3-methyladenine	207-211	cathepsin B	Rattus norvegicus	43-54
21660151-9	2011	Active GSK3beta in the presence of 3-MA resulted in significantly increased formation of insoluble tau aggregates.	3-methyladenine	35-39	glycogen synthase kinase 3 beta	Homo sapiens	7-15
21134415-6	2011	When pretreated with 3-methyladenine (3-MA), dopaminergic neurons were protected from cell death induced by 6-OHDA, associated with the suppression of LC3 and cathepsin L.	3-methyladenine	21-36	annexin A3	Rattus norvegicus	151-154
21134415-6	2011	When pretreated with 3-methyladenine (3-MA), dopaminergic neurons were protected from cell death induced by 6-OHDA, associated with the suppression of LC3 and cathepsin L.	3-methyladenine	21-36	cathepsin L	Rattus norvegicus	159-170
21134415-6	2011	When pretreated with 3-methyladenine (3-MA), dopaminergic neurons were protected from cell death induced by 6-OHDA, associated with the suppression of LC3 and cathepsin L.	3-methyladenine	38-42	annexin A3	Rattus norvegicus	151-154
21134415-6	2011	When pretreated with 3-methyladenine (3-MA), dopaminergic neurons were protected from cell death induced by 6-OHDA, associated with the suppression of LC3 and cathepsin L.	3-methyladenine	38-42	cathepsin L	Rattus norvegicus	159-170
24843461-11	2011	The viability of hIAPP-expressing cells was increased after treatment with rapamycin, an inducer of autophagy, and decreased after treatment with 3-methyladenine, an inhibitor of autophagy.	3-methyladenine	146-161	islet amyloid polypeptide	Homo sapiens	17-22
21146501-4	2011	In addition, Mo-PrP3(F)4 flies were significantly more susceptible to the perturbation of autophagy signaling by an autophagy inhibitor, 3-methyladenine (3-MA), and inducer, LiCl.	3-methyladenine	137-152	peroxiredoxin 2	Mus musculus	13-24
21146501-4	2011	In addition, Mo-PrP3(F)4 flies were significantly more susceptible to the perturbation of autophagy signaling by an autophagy inhibitor, 3-methyladenine (3-MA), and inducer, LiCl.	3-methyladenine	154-158	peroxiredoxin 2	Mus musculus	13-24
21691068-5	2011	We further demonstrated that GABARAPL1 mediates degradation of Dvl2 and the effect is blocked by addition of 3-MA, a specific inhibitor of autophagy.	3-methyladenine	109-113	GABA type A receptor associated protein like 1	Homo sapiens	29-38
21691068-5	2011	We further demonstrated that GABARAPL1 mediates degradation of Dvl2 and the effect is blocked by addition of 3-MA, a specific inhibitor of autophagy.	3-methyladenine	109-113	dishevelled segment polarity protein 2	Homo sapiens	63-67
21799881-8	2011	The number of neurons in the GCL decreased significantly following I/R (I/R 12.21+-1.13 vs controls 19.23+-1.12 cells/500 microm); this decrease was partially prevented by 3-methyladenine (17.08+-1.42 cells/500 microm), which potently inhibits maturation of autophagosomes.	3-methyladenine	172-187	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	29-32
20959456-7	2010	Inhibition of the autophagy-lysosome pathway by 3-methyladenine or chloroquine accumulated Ser-129-phosphorylated a-Syn in parallel to total a-Syn during longer incubations.	3-methyladenine	48-63	synemin	Homo sapiens	116-119
21211311-12	2010	The autophagy inhibitor 3-MA reversed the elevation of beclin 1 mRNA.	3-methyladenine	24-28	beclin 1	Homo sapiens	55-63
20930550-4	2010	STAT3 activation was associated with autophagic processes, because it was completely inhibited by 3-methyladenine, partially inhibited by knockdown of molecules associated with autophagic processes and blocked by antioxidants, DPI, a Nox inhibitor and knockdown of p22 phox, indicating that ROS generated by Nox that was activated during autophagic processes activated JAK2/STAT3 pathway.	3-methyladenine	98-113	signal transducer and activator of transcription 3	Homo sapiens	0-5
20699416-7	2010	In addition, inducing ER stress is sufficient to downregulate adiponectin levels in 3T3-L1 adipocytes, which could be protected by treating cells with the autophagy inhibitor 3-methyladenine or by overexpression of DsbA-L.	3-methyladenine	175-190	adiponectin, C1Q and collagen domain containing	Mus musculus	62-73
20696207-8	2010	Caspases were inhibited with zVAD-FMK and zDEVD-FMK; autophagy with 3-methyladenine, LY294002, and wortmannin.	3-methyladenine	68-83	caspase 8	Homo sapiens	0-8
20637870-4	2010	Under hypoxia, autophagy inhibition by 3-methyladenine or chloroquine significantly enhanced apoptosis and decreased cell viability in 4-HPR-exposed cells, indicating that autophagy prevents cancer cell death and presumably leads to hypoxia-induced resistance to 4-HPR.	3-methyladenine	39-54	haptoglobin-related protein	Homo sapiens	137-140
20637870-4	2010	Under hypoxia, autophagy inhibition by 3-methyladenine or chloroquine significantly enhanced apoptosis and decreased cell viability in 4-HPR-exposed cells, indicating that autophagy prevents cancer cell death and presumably leads to hypoxia-induced resistance to 4-HPR.	3-methyladenine	39-54	haptoglobin-related protein	Homo sapiens	265-268
19799646-9	2010	Autophagy was accompanied by the activation of Beclin and LC3-II as well as mTOR signalling, which were inhibited by either 3-methyl adenine (3-MA) or Wortmannin.	3-methyladenine	124-140	mechanistic target of rapamycin kinase	Rattus norvegicus	76-80
19799646-9	2010	Autophagy was accompanied by the activation of Beclin and LC3-II as well as mTOR signalling, which were inhibited by either 3-methyl adenine (3-MA) or Wortmannin.	3-methyladenine	142-146	mechanistic target of rapamycin kinase	Rattus norvegicus	76-80
20886049-9	2010	Serum starvation as an inducer of autophagy caused marked BAMBI degradation, which could be totally prevented by inhibition of lysosomal and autolysosomal degradation with bafilomycin, and partially by inhibition of autophagy with 3-methyladenine, but not by proteasomal inhibitors.	3-methyladenine	231-246	BMP and activin membrane-bound inhibitor	Mus musculus	58-63
20541008-6	2010	Co-incubation with bafilomycin A1 (10 nM) further increased hypoxia-induced LC3-II levels but 3-methyladenine (3-MA; 10 mM) reduced the elevation in LC3-II levels induced by 8-h hypoxia.	3-methyladenine	94-109	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	149-152
20541008-6	2010	Co-incubation with bafilomycin A1 (10 nM) further increased hypoxia-induced LC3-II levels but 3-methyladenine (3-MA; 10 mM) reduced the elevation in LC3-II levels induced by 8-h hypoxia.	3-methyladenine	111-115	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	149-152
20541008-13	2010	Co-incubation with 3-MA during hypoxia prevented the protection afforded by hypoxic preconditioning against MPP(+)-induced increases in LC3-II levels and neurotoxicity.	3-methyladenine	19-23	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	136-139
20730377-4	2010	When we transfected cells exposed to PQ with DJ-1-specific siRNA, we observed an inhibition of the autophagic events induced by the herbicide, as well as sensitization additive with PQ-induced apoptotic cell death and exacerbation of this cell death in the presence of the autophagy inhibitor 3-methyladenine.	3-methyladenine	293-308	Parkinsonism associated deglycase	Homo sapiens	45-49
20484657-5	2010	This proautophagic effect of ANG II was inhibited by pretreatment with 3-methyladenine, an inhibitor of autophagy.	3-methyladenine	71-86	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	29-35
20574158-10	2010	3-MA inhibited OGD-induced the increase in LC3-II and the decline in Bcl-2.	3-methyladenine	0-4	BCL2, apoptosis regulator	Rattus norvegicus	69-74
20489789-7	2010	We also documented that Ad-IFNalpha treatment produces the autophagic protein form, light chain 3 (LC3)-II, in cancer cells but not normal cells, which in turn was inhibited by the autophagic inhibitor, 3-methyladenine (3-MA).	3-methyladenine	203-218	interferon alpha 1	Homo sapiens	27-35
20489789-7	2010	We also documented that Ad-IFNalpha treatment produces the autophagic protein form, light chain 3 (LC3)-II, in cancer cells but not normal cells, which in turn was inhibited by the autophagic inhibitor, 3-methyladenine (3-MA).	3-methyladenine	220-224	interferon alpha 1	Homo sapiens	27-35
20472559-6	2010	TLR3-mediated type I interferon signaling required cellular autophagy and was suppressed by 3-methyladenine and bafilomycin A1, by inhibitors of lysosomal proteolysis, and by reduced expression of Beclin 1, Atg5, or microtubule-associated protein 1 light chain 3beta (MAP1LC3beta).	3-methyladenine	92-107	toll like receptor 3	Homo sapiens	0-4
20634405-6	2010	Knockdown of autophagy regulator beclin 1 or cell treatment with autophagy inhibitor 3-methyladenine, a class III PI3K (hVps34) inhibitor, also inhibited cetuximab-induced autophagy.	3-methyladenine	85-100	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	120-126
20371669-5	2010	Autophagy blocking by 3-methyladenine (3MA) or bafilomycin A1 (BaF1) activated caspase-4 and -7 and enhanced cell death.	3-methyladenine	22-37	caspase 4	Homo sapiens	79-95
20371669-5	2010	Autophagy blocking by 3-methyladenine (3MA) or bafilomycin A1 (BaF1) activated caspase-4 and -7 and enhanced cell death.	3-methyladenine	39-42	caspase 4	Homo sapiens	79-95
20350574-6	2010	Treatment of cells with an inhibitor of autophagosome formation, 3-methyladenine, both reduced LC3-GFP puncta formation and viral production, suggesting a role for autophagosomes in ISAV replication.	3-methyladenine	65-80	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	95-98
20513003-9	2010	Blocking autophagosome maturation using 3-methyladenine restored cell death in HIF-2alpha-knockdown clones comparable to wildtype cells.	3-methyladenine	40-55	endothelial PAS domain protein 1	Homo sapiens	79-89
20179157-6	2010	Simultaneous exposure of A-498 cells to ABC294640 and 3-methyladenine, an inhibitor of autophagy, switched the mechanism of toxicity to apoptosis, but decreased the potency of the SK2 inhibitor, indicating that autophagy is a major mechanism for tumor cell killing by this compound.	3-methyladenine	54-69	sphingosine kinase 2	Homo sapiens	180-183
20361931-9	2010	When heat shock was combined with 3-methyladenine (3-MA), an inhibitor of autophagy, the mitochondrial loss and the reduction of total cytochrome c were both inhibited, and then caspase-3 activation and cell apoptosis were increased.	3-methyladenine	34-49	cytochrome c, somatic	Homo sapiens	135-147
20361931-9	2010	When heat shock was combined with 3-methyladenine (3-MA), an inhibitor of autophagy, the mitochondrial loss and the reduction of total cytochrome c were both inhibited, and then caspase-3 activation and cell apoptosis were increased.	3-methyladenine	34-49	caspase 3	Homo sapiens	178-187
20361931-9	2010	When heat shock was combined with 3-methyladenine (3-MA), an inhibitor of autophagy, the mitochondrial loss and the reduction of total cytochrome c were both inhibited, and then caspase-3 activation and cell apoptosis were increased.	3-methyladenine	51-55	cytochrome c, somatic	Homo sapiens	135-147
20361931-9	2010	When heat shock was combined with 3-methyladenine (3-MA), an inhibitor of autophagy, the mitochondrial loss and the reduction of total cytochrome c were both inhibited, and then caspase-3 activation and cell apoptosis were increased.	3-methyladenine	51-55	caspase 3	Homo sapiens	178-187
20168088-7	2010	In contrast, 3-methyladenine (3MA) reduced the increased Beclin 1 expression, the MDC labeling and the neuroprotective effect of rapamycin without affecting Akt phosphorylation.	3-methyladenine	13-28	beclin 1	Homo sapiens	57-65
20168088-7	2010	In contrast, 3-methyladenine (3MA) reduced the increased Beclin 1 expression, the MDC labeling and the neuroprotective effect of rapamycin without affecting Akt phosphorylation.	3-methyladenine	30-33	beclin 1	Homo sapiens	57-65
20352108-5	2010	Neuroprotective effects of CysC were prevented by inhibiting autophagy with beclin 1 siRNA or 3-methyladenine.	3-methyladenine	94-109	cystatin C	Homo sapiens	27-31
19935772-4	2010	S100A8/A9-induced cell death was partially inhibited by the specific PI3-kinase class III inhibitor, 3-methyladenine (3-MA), and by the vacuole H(+)-ATPase inhibitor, bafilomycin-A1 (Baf-A1).	3-methyladenine	101-116	S100 calcium binding protein A8	Homo sapiens	0-6
19935772-4	2010	S100A8/A9-induced cell death was partially inhibited by the specific PI3-kinase class III inhibitor, 3-methyladenine (3-MA), and by the vacuole H(+)-ATPase inhibitor, bafilomycin-A1 (Baf-A1).	3-methyladenine	118-122	S100 calcium binding protein A8	Homo sapiens	0-6
19798749-8	2010	In addition, the autophagy inhibitor 3-methyladenine (3MA) blocked degradation of both TDP-43 types, whereas lactacystin was minimally restorative.	3-methyladenine	37-52	TAR DNA binding protein	Homo sapiens	87-93
19798749-8	2010	In addition, the autophagy inhibitor 3-methyladenine (3MA) blocked degradation of both TDP-43 types, whereas lactacystin was minimally restorative.	3-methyladenine	54-57	TAR DNA binding protein	Homo sapiens	87-93
19830499-10	2010	Treatment of cells with a specific autophagy inhibitor (3-methyladenine) potentiated the proapoptotic effect of SUL, which was dependent on the activation of caspases and the release of cytochrome c to the cytosol.	3-methyladenine	56-71	cytochrome c, somatic	Homo sapiens	186-198
20104024-10	2010	3-methyladenine (3-MA) blocked LC3 conversion, and 3-MA and wortmannin significantly enhanced apoptotic signaling in cells treated with celecoxib plus ABT-737.	3-methyladenine	0-15	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	31-34
20104024-10	2010	3-methyladenine (3-MA) blocked LC3 conversion, and 3-MA and wortmannin significantly enhanced apoptotic signaling in cells treated with celecoxib plus ABT-737.	3-methyladenine	17-21	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	31-34
20187799-8	2010	We also found that 3-MA can enhance the growth inhibition and apoptotic effect of cisplatin in acquired resistant cells (A549/DDP).	3-methyladenine	19-23	translocase of inner mitochondrial membrane 8A	Homo sapiens	126-129
19874831-1	2010	We recently demonstrated that Polzeta and Rev1 contribute to alleviate the lethal effects of Me-lex, which selectively generates 3-methyladenine, by error prone lesion bypass.	3-methyladenine	129-144	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	42-46
20008137-1	2010	Sodium arsenite (NaAs)-induced autophagic cell death (ACD) of a mouse renal tubular epithelial cell line (mProx24), which expresses enhanced levels of interleukin-6 (IL-6), was reduced by the suppression of autophagy by 3-methyladenine or Atg7 knockdown.	3-methyladenine	220-235	interleukin 6	Mus musculus	151-164
19887566-8	2010	The proteasomal inhibitor epoxomicin and the lysosomal pathway inhibitor 3-methyladenine prevented the degradation of IRS-1 and IR by insulin, respectively, and pretreatment with rapamycin, epoxomicin, or 3-methyladenine prevented attenuation of insulin signaling by long-term insulin exposure.	3-methyladenine	73-88	insulin receptor substrate 1	Homo sapiens	118-123
19887566-8	2010	The proteasomal inhibitor epoxomicin and the lysosomal pathway inhibitor 3-methyladenine prevented the degradation of IRS-1 and IR by insulin, respectively, and pretreatment with rapamycin, epoxomicin, or 3-methyladenine prevented attenuation of insulin signaling by long-term insulin exposure.	3-methyladenine	73-88	insulin receptor	Homo sapiens	118-120
19887566-8	2010	The proteasomal inhibitor epoxomicin and the lysosomal pathway inhibitor 3-methyladenine prevented the degradation of IRS-1 and IR by insulin, respectively, and pretreatment with rapamycin, epoxomicin, or 3-methyladenine prevented attenuation of insulin signaling by long-term insulin exposure.	3-methyladenine	73-88	insulin	Homo sapiens	134-141
19887566-8	2010	The proteasomal inhibitor epoxomicin and the lysosomal pathway inhibitor 3-methyladenine prevented the degradation of IRS-1 and IR by insulin, respectively, and pretreatment with rapamycin, epoxomicin, or 3-methyladenine prevented attenuation of insulin signaling by long-term insulin exposure.	3-methyladenine	73-88	insulin	Homo sapiens	246-253
19887566-8	2010	The proteasomal inhibitor epoxomicin and the lysosomal pathway inhibitor 3-methyladenine prevented the degradation of IRS-1 and IR by insulin, respectively, and pretreatment with rapamycin, epoxomicin, or 3-methyladenine prevented attenuation of insulin signaling by long-term insulin exposure.	3-methyladenine	73-88	insulin	Homo sapiens	246-253
19887566-8	2010	The proteasomal inhibitor epoxomicin and the lysosomal pathway inhibitor 3-methyladenine prevented the degradation of IRS-1 and IR by insulin, respectively, and pretreatment with rapamycin, epoxomicin, or 3-methyladenine prevented attenuation of insulin signaling by long-term insulin exposure.	3-methyladenine	205-220	insulin receptor substrate 1	Homo sapiens	118-123
19887566-8	2010	The proteasomal inhibitor epoxomicin and the lysosomal pathway inhibitor 3-methyladenine prevented the degradation of IRS-1 and IR by insulin, respectively, and pretreatment with rapamycin, epoxomicin, or 3-methyladenine prevented attenuation of insulin signaling by long-term insulin exposure.	3-methyladenine	205-220	insulin receptor	Homo sapiens	118-120
25214972-0	2010	Autophagy inhibitor 3-methyladenine regulates the expression of LC3, Beclin-1 and ZnTs in rat cerebral cortex following recurrent neonatal seizures.	3-methyladenine	20-35	beclin 1	Rattus norvegicus	69-77
25214972-4	2010	The present study was to investigate the effects of recurrent neonatal seizure, in the presence and absence of autophagy inhibitor 3-methyladenine (3-MA), on the acute phase gene expression of ZnTs, LC3 and Beclin-1 in rat cerebral cortex and the interaction among them.	3-methyladenine	131-146	beclin 1	Rattus norvegicus	207-215
19565656-7	2009	Pretreatment with the autophagy inhibitor 3-methyladenine (3-MA) significantly inhibited the 3-NP-induced alterations in beclin 1 and Bcl-2 protein levels.	3-methyladenine	42-57	beclin 1	Rattus norvegicus	121-129
19565656-7	2009	Pretreatment with the autophagy inhibitor 3-methyladenine (3-MA) significantly inhibited the 3-NP-induced alterations in beclin 1 and Bcl-2 protein levels.	3-methyladenine	42-57	BCL2, apoptosis regulator	Rattus norvegicus	134-139
19565656-7	2009	Pretreatment with the autophagy inhibitor 3-methyladenine (3-MA) significantly inhibited the 3-NP-induced alterations in beclin 1 and Bcl-2 protein levels.	3-methyladenine	59-63	beclin 1	Rattus norvegicus	121-129
19565656-7	2009	Pretreatment with the autophagy inhibitor 3-methyladenine (3-MA) significantly inhibited the 3-NP-induced alterations in beclin 1 and Bcl-2 protein levels.	3-methyladenine	59-63	BCL2, apoptosis regulator	Rattus norvegicus	134-139
19565656-10	2009	3-MA also attenuated the 3-NP-induced release of cytochrome c. On the other hand, 3-NP-induced elevations in proapoptotic protein Bax and autophagic protein beclin 1 and LC3-II were significantly enhanced by the Bcl-2-specific inhibitor HA14-1.	3-methyladenine	0-4	BCL2, apoptosis regulator	Rattus norvegicus	212-217
19958950-9	2009	Treatment with 3-MA abrogated the radiation-induced increase in LC3-II in both cell lines and reduced radiosensitivity by 49% and 31% in 8505-C and TPC-1 cells, respectively.	3-methyladenine	15-19	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	64-67
19786832-5	2009	However, when autophagy was inhibited by 3-MA or siRNA targeted Beclin 1, this reduction was reversed, i.e., chemoresistance was attenuated, which means autophagy mediates the chemoresistance under hypoxia.	3-methyladenine	41-45	beclin 1	Homo sapiens	64-72
19864570-6	2009	The effects of beclin 1 overexpression on LC3 and alpha-syn accumulation were partially blocked by 3-MA and completely blocked by bafilomycin A1.	3-methyladenine	99-103	beclin 1	Homo sapiens	15-23
19864570-6	2009	The effects of beclin 1 overexpression on LC3 and alpha-syn accumulation were partially blocked by 3-MA and completely blocked by bafilomycin A1.	3-methyladenine	99-103	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	42-45
19864570-6	2009	The effects of beclin 1 overexpression on LC3 and alpha-syn accumulation were partially blocked by 3-MA and completely blocked by bafilomycin A1.	3-methyladenine	99-103	synuclein alpha	Homo sapiens	50-59
19541767-6	2009	The ER stress-induced reduction in IR cellular levels was greatly alleviated by the autophagy inhibitor 3-methyladenine but not by the proteasome inhibitor N-benzoyloxycarbonyl (Z)-Leu-Leu-leucinal (MG132).	3-methyladenine	104-119	insulin receptor	Mus musculus	35-37
19371771-5	2009	Neu2 activity and protein levels were rescued upon cotreatment with the lysosomotropic agent NH4Cl, the autophagy inhibitor 3-methyladenine or cathepsin inhibitors, as well as by insulin administration, but were unaffected upon pharmacological inhibition of the proteasome.	3-methyladenine	124-139	neuraminidase 2	Homo sapiens	0-4
19337030-4	2009	Furthermore, we found that pretreatment with the autophagy inhibitor 3-methyladenine or beclin 1 siRNA further activated p53 and its downstream apoptotic pathways, while the autophagy inducer rapamycin showed the opposite effects.	3-methyladenine	69-84	tumor protein p53	Homo sapiens	121-124
19571141-2	2009	Here we show that the autophagy inhibitor 3-methyladenine delays neuronal cell loss caused by dysfunctional endosomal sorting complex required for transport III (ESCRT-III), either through loss of its essential component mSnf7-2 or ectopic expression of the disease protein CHMP2B(Intron5), which is associated with frontotemporal dementia linked to chromosome 3.	3-methyladenine	42-57	charged multivesicular body protein 2B	Homo sapiens	274-280
18063223-6	2009	Furthermore, we demonstrated that repeated hypoxia treatment can activate macroautophagy, which may contribute to the increases in Abeta production since pretreatment with macroautophagy inhibitor 3-methyladenine significantly blocked chemical hypoxic condition-induced increase in Abeta production in SH-SY5Y cells.	3-methyladenine	197-212	amyloid beta precursor protein	Homo sapiens	131-136
18063223-6	2009	Furthermore, we demonstrated that repeated hypoxia treatment can activate macroautophagy, which may contribute to the increases in Abeta production since pretreatment with macroautophagy inhibitor 3-methyladenine significantly blocked chemical hypoxic condition-induced increase in Abeta production in SH-SY5Y cells.	3-methyladenine	197-212	amyloid beta precursor protein	Homo sapiens	282-287
19424588-6	2009	Our results demonstrate that MUC1 blocks depletion of ATP and sustains growth of glucose-deprived cells by a mechanism sensitive to the autophagy inhibitor, 3-methyladenine.	3-methyladenine	157-172	mucin 1, cell surface associated	Homo sapiens	29-33
19400951-11	2009	Treatment of vector control K562 cells with the autophagy inhibitors 3-methyladenine and bafilomycin A1 recapitulated the growth kinetics, vacuolar morphology and LC3-II accumulation of CSN2 knockdown cells indicating that the cellular phenotype of CSN2 cells arises from autophagy inhibition.	3-methyladenine	69-84	casein beta	Homo sapiens	186-190
19400951-11	2009	Treatment of vector control K562 cells with the autophagy inhibitors 3-methyladenine and bafilomycin A1 recapitulated the growth kinetics, vacuolar morphology and LC3-II accumulation of CSN2 knockdown cells indicating that the cellular phenotype of CSN2 cells arises from autophagy inhibition.	3-methyladenine	69-84	casein beta	Homo sapiens	249-253
19258012-6	2009	In this connection, 3-methyladenine, a Class III phosphoinositide 3-kinase inhibitor, significantly abolished the formation of LC3(+) autophagic vacuoles and the processing of LC3 induced by sc-560.	3-methyladenine	20-35	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	127-130
19258012-6	2009	In this connection, 3-methyladenine, a Class III phosphoinositide 3-kinase inhibitor, significantly abolished the formation of LC3(+) autophagic vacuoles and the processing of LC3 induced by sc-560.	3-methyladenine	20-35	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	176-179
19219989-1	2009	The human 3-methyladenine DNA glycosylase (AAG) recognizes and excises a broad range of purines damaged by alkylation and oxidative damage, including 3-methyladenine, 7-methylguanine, hypoxanthine (Hx), and 1,N(6)-ethenoadenine (epsilonA).	3-methyladenine	10-25	N-methylpurine DNA glycosylase	Homo sapiens	43-46
19116755-13	2009	Moreover, the anti-apoptotic protein, Bcl-xL, was significantly downregulated by 3-MA.	3-methyladenine	81-85	BCL2 like 1	Homo sapiens	38-44
19017649-5	2009	We validated this nutrient-limited media approach for inducing autophagy by showing that 3-methyl-adenine treatment and Atg5 RNA interference knockdown each inhibits LC3-I to LC3-II conversion.	3-methyladenine	89-105	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	166-169
19017649-5	2009	We validated this nutrient-limited media approach for inducing autophagy by showing that 3-methyl-adenine treatment and Atg5 RNA interference knockdown each inhibits LC3-I to LC3-II conversion.	3-methyladenine	89-105	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	175-178
19059269-7	2009	KEY FINDINGS: Western blotting analysis showed that the macroautophagy inhibitors 3-methyladenine and ammonium chloride increased the levels of a heterologously expressed NTE-GFP fusion protein as well as endogenous NTE.	3-methyladenine	82-97	patatin like phospholipase domain containing 6	Homo sapiens	171-174
19059269-7	2009	KEY FINDINGS: Western blotting analysis showed that the macroautophagy inhibitors 3-methyladenine and ammonium chloride increased the levels of a heterologously expressed NTE-GFP fusion protein as well as endogenous NTE.	3-methyladenine	82-97	patatin like phospholipase domain containing 6	Homo sapiens	216-219
19331148-7	2009	Pretreatment with 3-methyladenine, an inhibitor of autophagy, partially inhibited the cytotoxicity of TFs, the formation of acidic organelles and LC3 accumulation in the autophagosome.	3-methyladenine	18-33	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	146-149
19197385-8	2009	Most important for the mechanistic understanding, the inhibition of vesicular trafficking by 3-methyladenine (3-MA) inhibited IP-10 but not IL-6 expression, mimicking the inhibitory effects of L. casei.	3-methyladenine	93-108	chemokine (C-X-C motif) ligand 10	Mus musculus	126-131
19197385-8	2009	Most important for the mechanistic understanding, the inhibition of vesicular trafficking by 3-methyladenine (3-MA) inhibited IP-10 but not IL-6 expression, mimicking the inhibitory effects of L. casei.	3-methyladenine	110-114	chemokine (C-X-C motif) ligand 10	Mus musculus	126-131
18996088-5	2008	Further experiments confirmed that JNK was activated by CH11 dose-dependently, and the activation was suppressed when autophagy was blocked by 3-MA.	3-methyladenine	143-147	mitogen-activated protein kinase 8	Homo sapiens	35-38
19074260-5	2008	This targeting requires the ubiquitin-binding protein, p62, and is blocked by the Class III phosphatidylinositol 3-kinase (PI3K) inhibitor, 3-methyladenine (3-MA), or by depletion of the autophagy-related-12 (Atg12) protein homolog.	3-methyladenine	140-155	nucleoporin 62	Homo sapiens	55-58
19074260-5	2008	This targeting requires the ubiquitin-binding protein, p62, and is blocked by the Class III phosphatidylinositol 3-kinase (PI3K) inhibitor, 3-methyladenine (3-MA), or by depletion of the autophagy-related-12 (Atg12) protein homolog.	3-methyladenine	140-155	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	92-121
19074260-5	2008	This targeting requires the ubiquitin-binding protein, p62, and is blocked by the Class III phosphatidylinositol 3-kinase (PI3K) inhibitor, 3-methyladenine (3-MA), or by depletion of the autophagy-related-12 (Atg12) protein homolog.	3-methyladenine	140-155	autophagy related 12	Homo sapiens	187-207
19074260-5	2008	This targeting requires the ubiquitin-binding protein, p62, and is blocked by the Class III phosphatidylinositol 3-kinase (PI3K) inhibitor, 3-methyladenine (3-MA), or by depletion of the autophagy-related-12 (Atg12) protein homolog.	3-methyladenine	140-155	autophagy related 12	Homo sapiens	209-214
19074260-5	2008	This targeting requires the ubiquitin-binding protein, p62, and is blocked by the Class III phosphatidylinositol 3-kinase (PI3K) inhibitor, 3-methyladenine (3-MA), or by depletion of the autophagy-related-12 (Atg12) protein homolog.	3-methyladenine	157-161	nucleoporin 62	Homo sapiens	55-58
19074260-5	2008	This targeting requires the ubiquitin-binding protein, p62, and is blocked by the Class III phosphatidylinositol 3-kinase (PI3K) inhibitor, 3-methyladenine (3-MA), or by depletion of the autophagy-related-12 (Atg12) protein homolog.	3-methyladenine	157-161	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	92-121
19074260-5	2008	This targeting requires the ubiquitin-binding protein, p62, and is blocked by the Class III phosphatidylinositol 3-kinase (PI3K) inhibitor, 3-methyladenine (3-MA), or by depletion of the autophagy-related-12 (Atg12) protein homolog.	3-methyladenine	157-161	autophagy related 12	Homo sapiens	187-207
19074260-5	2008	This targeting requires the ubiquitin-binding protein, p62, and is blocked by the Class III phosphatidylinositol 3-kinase (PI3K) inhibitor, 3-methyladenine (3-MA), or by depletion of the autophagy-related-12 (Atg12) protein homolog.	3-methyladenine	157-161	autophagy related 12	Homo sapiens	209-214
18836180-8	2008	The importance of PKCdelta in hypoxic stress-induced adaptive responses is further supported by our findings that inhibition of PKCdelta-facilitated autophagy by 3-methyladenine or Atg5 knock-out renders a greater prevalence of cell death following prolonged desferroxamine treatment, whereas PKCdelta- or JNK1-deficient cells exhibit resistance to extended hypoxic exposure.	3-methyladenine	162-177	protein kinase C, delta	Rattus norvegicus	18-26
18836180-8	2008	The importance of PKCdelta in hypoxic stress-induced adaptive responses is further supported by our findings that inhibition of PKCdelta-facilitated autophagy by 3-methyladenine or Atg5 knock-out renders a greater prevalence of cell death following prolonged desferroxamine treatment, whereas PKCdelta- or JNK1-deficient cells exhibit resistance to extended hypoxic exposure.	3-methyladenine	162-177	protein kinase C, delta	Rattus norvegicus	128-136
18836180-8	2008	The importance of PKCdelta in hypoxic stress-induced adaptive responses is further supported by our findings that inhibition of PKCdelta-facilitated autophagy by 3-methyladenine or Atg5 knock-out renders a greater prevalence of cell death following prolonged desferroxamine treatment, whereas PKCdelta- or JNK1-deficient cells exhibit resistance to extended hypoxic exposure.	3-methyladenine	162-177	protein kinase C, delta	Rattus norvegicus	128-136
18760364-7	2008	3-Methyladenine and wortmannin, that inhibit autophagy, significantly reduced beclin 1 expression and switched the mechanism of the cell death mode from apoptosis to necrosis.	3-methyladenine	0-15	beclin 1	Homo sapiens	78-86
18818525-6	2008	Blocking of autophagy by 3-methyladenine (3MA) as well as siRNA Atg5 induced a high level of caspase-3 activation.	3-methyladenine	25-40	caspase 3	Homo sapiens	93-102
18818525-6	2008	Blocking of autophagy by 3-methyladenine (3MA) as well as siRNA Atg5 induced a high level of caspase-3 activation.	3-methyladenine	42-45	caspase 3	Homo sapiens	93-102
18927491-10	2008	In particular, 3 methyladenine (3MA) and wortmannin, two macroautophagic inhibitors, prevented both the decrease of HIF-1alpha protein levels and LC3 processing in cells treated with CR 3294.	3-methyladenine	15-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-126
18927491-10	2008	In particular, 3 methyladenine (3MA) and wortmannin, two macroautophagic inhibitors, prevented both the decrease of HIF-1alpha protein levels and LC3 processing in cells treated with CR 3294.	3-methyladenine	32-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-126
18959757-5	2008	Inhibition of autophagy by the inhibitor 3-methyladenine attenuated the cell death induced by integrin beta4 knockdown.	3-methyladenine	41-56	integrin subunit beta 4	Homo sapiens	94-108
18708346-7	2008	The hypothesis that NRP1 is degraded by autophagy is supported by the findings that its expression is lost rapidly in response to metabolic stress, prevented with 3-methyladenine and induced by rapamycin.	3-methyladenine	163-178	neuropilin 1	Homo sapiens	20-24
18551133-3	2008	Here, we demonstrated that although ER stress-induced autophagy was suppressed by class III phosphatidylinositol-3"-kinase (PI3KC3) inhibitor 3-methyladenine (3-MA), wortmannin and knockdown of Beclin1 using small interfering RNA (siRNA), only 3-MA suppressed UPR activation.	3-methyladenine	159-163	beclin 1	Homo sapiens	194-201
18758240-4	2008	We found that in IL-3-dependent FL5.12 cells, NIH3T3 cells and mouse embryo fibroblasts induced to arrest, treatment with 3-methyladenine did not affect the expected decrease in cell size and ribosomal RNA synthesis, or upregulation of p27 levels.	3-methyladenine	122-137	interleukin 3	Mus musculus	17-21
18567942-10	2008	The neuroprotective effects of 3-MA and Z-FA-fmk were associated with an inhibition on ischemia-induced upregulation of LC3-II and cathepsin B and a partial reversion of ischemia-induced downregulation of cytoprotective Bcl-2.	3-methyladenine	31-35	cathepsin B	Rattus norvegicus	131-142
18567942-10	2008	The neuroprotective effects of 3-MA and Z-FA-fmk were associated with an inhibition on ischemia-induced upregulation of LC3-II and cathepsin B and a partial reversion of ischemia-induced downregulation of cytoprotective Bcl-2.	3-methyladenine	31-35	BCL2, apoptosis regulator	Rattus norvegicus	220-225
18369370-6	2008	Upon treatment with the autophagic inhibitor 3-methyladenine, retinas accumulated numerous TdT-mediated dUTP nick-end labelling-positive cells that correlated with a lack of the "eat-me" signal phosphatidylserine (PS).	3-methyladenine	45-60	DNA nucleotidylexotransferase	Gallus gallus	91-94
18505729-3	2008	Wortmannin and 3-methyladenine, inhibitors of class III phosphatidylinostol 3-kinase and, subsequently, autophagy, blocked apoL1-induced AuCD.	3-methyladenine	15-30	apolipoprotein L1	Homo sapiens	123-128
18398293-4	2008	Moreover, EGFR mitochondrial translocation can be increased by rapamycin treatment in A431 cells and greatly reduced by the presence of 3-methyladenine (3-MA), an inhibitor of autophagy.	3-methyladenine	136-151	epidermal growth factor receptor	Homo sapiens	10-14
18398293-4	2008	Moreover, EGFR mitochondrial translocation can be increased by rapamycin treatment in A431 cells and greatly reduced by the presence of 3-methyladenine (3-MA), an inhibitor of autophagy.	3-methyladenine	153-157	epidermal growth factor receptor	Homo sapiens	10-14
18313411-9	2008	Interestingly, proteasome inhibitors (MG132 and Lactacystin) and an autophagy inhibitor (3-methyladenine) reversed CO influence iNOS levels.	3-methyladenine	89-104	inositol-3-phosphate synthase 1	Homo sapiens	128-132
18299661-6	2008	GST-MDA-7 caused PERK-dependent vacuolization of LC3-expressing endosomes whose formation was suppressed by incubation with 3-methyladenine, expression of HSP70 or of BiP/GRP78, or by knockdown of ATG5 or Beclin 1 expression, but not by inhibition of the JNK1-3 pathway.	3-methyladenine	124-139	interleukin 24	Homo sapiens	4-9
18299661-6	2008	GST-MDA-7 caused PERK-dependent vacuolization of LC3-expressing endosomes whose formation was suppressed by incubation with 3-methyladenine, expression of HSP70 or of BiP/GRP78, or by knockdown of ATG5 or Beclin 1 expression, but not by inhibition of the JNK1-3 pathway.	3-methyladenine	124-139	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	17-21
18299661-6	2008	GST-MDA-7 caused PERK-dependent vacuolization of LC3-expressing endosomes whose formation was suppressed by incubation with 3-methyladenine, expression of HSP70 or of BiP/GRP78, or by knockdown of ATG5 or Beclin 1 expression, but not by inhibition of the JNK1-3 pathway.	3-methyladenine	124-139	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	49-52
18195017-10	2008	The autophagy inhibitor 3-methyladenine inhibits the DAPK-1 plus MAP1B-mediated membrane blebbing.	3-methyladenine	24-39	death associated protein kinase 1	Homo sapiens	53-59
18195017-10	2008	The autophagy inhibitor 3-methyladenine inhibits the DAPK-1 plus MAP1B-mediated membrane blebbing.	3-methyladenine	24-39	microtubule associated protein 1B	Homo sapiens	65-70
18256309-7	2008	Autophagy inhibitors LY294002 or 3-methyladenine or wortmannin inhibited the formation of autophagosomes but induced apoptosis after 2-4 h of cisplatin treatment as indicated by caspase-3/7 and -6 activation, nuclear fragmentation, and cell death.	3-methyladenine	33-48	caspase 3	Homo sapiens	178-196
18174255-7	2008	Autophagy inhibition at an early stage by 3-methyl adenine inhibited the AVO formation and LC3 localization with an enhancement in cell death.	3-methyladenine	42-58	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	91-94
18294209-9	2008	Additionally, exposure of cells to the autophagy inhibitor, 3-methyladenine, led to tau accumulation and aggregation.	3-methyladenine	60-75	microtubule associated protein tau	Homo sapiens	84-87
17873911-9	2008	The survival of BIK-expressing Bcl-2-/- cells was enhanced in the presence of PI3 kinase inhibitors 3-methyladenine and Wortmannin and also by depletion of Atg5 and Beclin-1.	3-methyladenine	100-115	BCL2-interacting killer	Mus musculus	16-19
17873911-9	2008	The survival of BIK-expressing Bcl-2-/- cells was enhanced in the presence of PI3 kinase inhibitors 3-methyladenine and Wortmannin and also by depletion of Atg5 and Beclin-1.	3-methyladenine	100-115	B cell leukemia/lymphoma 2	Mus musculus	31-36
18162182-4	2008	Rab21-positive tubules were also formed by the treatment of cells with 3-methyladenine (3-MA), which inhibits class III PI3K rather than class I PI3K.	3-methyladenine	71-86	RAB21, member RAS oncogene family	Homo sapiens	0-5
18162182-4	2008	Rab21-positive tubules were also formed by the treatment of cells with 3-methyladenine (3-MA), which inhibits class III PI3K rather than class I PI3K.	3-methyladenine	88-92	RAB21, member RAS oncogene family	Homo sapiens	0-5
18094625-6	2008	KA-induced increases in the ratio of LC3-II/LC3-I, LAMP2, cathepsin B, release of cytochrome c and activation of caspase-3 were blocked by pre-treatment with 3-MA.	3-methyladenine	158-162	cathepsin B	Rattus norvegicus	58-69
18281515-8	2008	GST-MDA-7 caused PERK-dependent vacuolization of LC3-expressing endosomes whose formation was suppressed by incubation with 3-methyladenine, expression of HSP70 or BiP/GRP78, or knockdown of ATG5 or Beclin-1 expression but not by inhibition of the JNK1-3 pathway.	3-methyladenine	124-139	interleukin 24	Homo sapiens	4-9
18281515-8	2008	GST-MDA-7 caused PERK-dependent vacuolization of LC3-expressing endosomes whose formation was suppressed by incubation with 3-methyladenine, expression of HSP70 or BiP/GRP78, or knockdown of ATG5 or Beclin-1 expression but not by inhibition of the JNK1-3 pathway.	3-methyladenine	124-139	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	17-21
18281515-8	2008	GST-MDA-7 caused PERK-dependent vacuolization of LC3-expressing endosomes whose formation was suppressed by incubation with 3-methyladenine, expression of HSP70 or BiP/GRP78, or knockdown of ATG5 or Beclin-1 expression but not by inhibition of the JNK1-3 pathway.	3-methyladenine	124-139	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	49-52
18032788-7	2007	Blocking the expression of autophagic genes (beclin 1 and ATG5) by siRNAs or using the autophagy inhibitor 3-methyladenine (3-MA) decreased cell death that was induced by rotenone or TTFA.	3-methyladenine	124-128	beclin 1	Homo sapiens	45-53
18032788-7	2007	Blocking the expression of autophagic genes (beclin 1 and ATG5) by siRNAs or using the autophagy inhibitor 3-methyladenine (3-MA) decreased cell death that was induced by rotenone or TTFA.	3-methyladenine	124-128	autophagy related 5	Homo sapiens	58-62
18094523-5	2007	In oridonin-induced Hela cells, pretreatment with 3-methyladenine (3-MA, the specific inhibitor of autophagy) dose-dependently decreased the autophagic ratio accompanied with downregulation of the protein expressions of MAP-LC3 and Beclin 1.	3-methyladenine	50-65	beclin 1	Homo sapiens	232-240
18094523-5	2007	In oridonin-induced Hela cells, pretreatment with 3-methyladenine (3-MA, the specific inhibitor of autophagy) dose-dependently decreased the autophagic ratio accompanied with downregulation of the protein expressions of MAP-LC3 and Beclin 1.	3-methyladenine	67-71	beclin 1	Homo sapiens	232-240
17824834-4	2007	When autophagy was blocked by inhibitors of autophagy, including 3-methyladenine, both the expression of beclin 1 protein and the antitumor effect of etoposide were suppressed.	3-methyladenine	65-80	beclin 1	Homo sapiens	105-113
17897837-20	2007	Therefore, triazene compounds can also kill tumour cells by a N(3)-methyladenine-mediated mechanism if BER activity is inhibited by chemical agents (i.e. PARP inhibitors).	3-methyladenine	62-80	poly(ADP-ribose) polymerase 1	Homo sapiens	154-158
17473426-8	2007	Furthermore, combined treatment with oridonin and 3-MA upregulated ERK phosphorylation and downregulated JNK and P38 kinases phosphorylation compared with oridonin alone treatment groups, indicating that autophagy facilitated apoptosis in oridonin-induced MCF-7 cells.	3-methyladenine	50-54	mitogen-activated protein kinase 1	Homo sapiens	67-70
17473426-8	2007	Furthermore, combined treatment with oridonin and 3-MA upregulated ERK phosphorylation and downregulated JNK and P38 kinases phosphorylation compared with oridonin alone treatment groups, indicating that autophagy facilitated apoptosis in oridonin-induced MCF-7 cells.	3-methyladenine	50-54	mitogen-activated protein kinase 8	Homo sapiens	105-108
17473426-9	2007	In addition, 3-MA application downregulated DNA ladder and Bax expression but upregulated Bcl-2 expression, compared with oridonin alone treatment.	3-methyladenine	13-17	BCL2 associated X, apoptosis regulator	Homo sapiens	59-62
17473426-9	2007	In addition, 3-MA application downregulated DNA ladder and Bax expression but upregulated Bcl-2 expression, compared with oridonin alone treatment.	3-methyladenine	13-17	BCL2 apoptosis regulator	Homo sapiens	90-95
17255284-10	2007	CONCLUSIONS: (a) Me-lex is cytotoxic in human glioma cells and AAG promotes resistance, indicating that 3-meA is a lethal lesion in these cells.	3-methyladenine	104-109	N-methylpurine DNA glycosylase	Homo sapiens	63-66
17255284-11	2007	(b) Abasic sites resulting from 3-meA repair are cytotoxic and Ape1 promotes resistance to these derivative lesions.	3-methyladenine	32-37	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	63-67
16740722-4	2006	Treatment of cells with a specific inhibitor of autophagy (3-methyladenine) attenuated localization of LC3 to autophagosomes but exacerbated cytosolic release of cytochrome c as well as apoptotic cell death as revealed by analysis of subdiploid fraction and cytoplasmic histone-associated DNA fragmentation.	3-methyladenine	59-74	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	103-106
16740722-4	2006	Treatment of cells with a specific inhibitor of autophagy (3-methyladenine) attenuated localization of LC3 to autophagosomes but exacerbated cytosolic release of cytochrome c as well as apoptotic cell death as revealed by analysis of subdiploid fraction and cytoplasmic histone-associated DNA fragmentation.	3-methyladenine	59-74	cytochrome c, somatic	Homo sapiens	162-174
16644476-7	2006	Moreover, another PI3K inhibitor 3-methyladenine also strongly enhanced IL-1-induced NF-kappaB DNA binding, while LY303511, an inactive analogue of LY29, did not increase the NF-kappaB DNA binding.	3-methyladenine	33-48	interleukin 1 alpha	Homo sapiens	72-76
16644476-7	2006	Moreover, another PI3K inhibitor 3-methyladenine also strongly enhanced IL-1-induced NF-kappaB DNA binding, while LY303511, an inactive analogue of LY29, did not increase the NF-kappaB DNA binding.	3-methyladenine	33-48	nuclear factor kappa B subunit 1	Homo sapiens	85-94
16597703-7	2006	ApoB-crescents began to decrease after 12-24 h of proteasomal inhibition, but the decrease was blocked by an autophagy inhibitor, 3-methyladenine.	3-methyladenine	130-145	apolipoprotein B	Homo sapiens	0-4
16415355-2	2006	Here we show that overexpression of sphingosine kinase 1 (SK1), an enzyme responsible for the production of sphingosine 1-phosphate (S1P), in MCF-7 cells stimulates autophagy by increasing the formation of LC3-positive autophagosomes and the rate of proteolysis sensitive to the autophagy inhibitor 3-methyladenine.	3-methyladenine	299-314	sphingosine kinase 1	Homo sapiens	36-56
16415355-2	2006	Here we show that overexpression of sphingosine kinase 1 (SK1), an enzyme responsible for the production of sphingosine 1-phosphate (S1P), in MCF-7 cells stimulates autophagy by increasing the formation of LC3-positive autophagosomes and the rate of proteolysis sensitive to the autophagy inhibitor 3-methyladenine.	3-methyladenine	299-314	sphingosine kinase 1	Homo sapiens	58-61
17146146-7	2006	The production of PtdIns(3)P and the recruitment of EEA1 to macropinosomes were abolished by the 3-MA treatment.	3-methyladenine	97-101	early endosome antigen 1	Homo sapiens	52-56
17146146-8	2006	Therefore, it is likely that 3-MA impairs recruitment of EEA1 by inhibiting PtdIns(3)P production and resultantly blocks the fusion of macropinosomes.	3-methyladenine	29-33	early endosome antigen 1	Homo sapiens	57-61
16151633-8	2005	3-methyladenine suppressed caspase activation less than zVAD did.	3-methyladenine	0-15	caspase 6	Homo sapiens	27-34
15990363-1	2005	Alkyladenine DNA glycosylase (AAG) excises a structurally diverse group of damaged purines including hypoxanthine, 1,N(6)-ethenoadenine, 3-methyladenine, and 7-methylguanine from DNA to initiate base excision repair at these sites.	3-methyladenine	137-152	N-methylpurine DNA glycosylase	Homo sapiens	0-28
15990363-1	2005	Alkyladenine DNA glycosylase (AAG) excises a structurally diverse group of damaged purines including hypoxanthine, 1,N(6)-ethenoadenine, 3-methyladenine, and 7-methylguanine from DNA to initiate base excision repair at these sites.	3-methyladenine	137-152	N-methylpurine DNA glycosylase	Homo sapiens	30-33
15778222-8	2005	3-Methyladenine or expression of Atg5(K130R) mutant blocks both cell death and vacuole formation triggered by IFN-gamma, whereas benzyloxycarbonyl-VAD-fluoromethyl ketone (Z-VAD-fmk) inhibits only cell death but not vacuole formation.	3-methyladenine	0-15	interferon gamma	Homo sapiens	110-119
15713479-6	2005	Since MPG has a role in removing adducts such as 3-methyladenine that block DNA synthesis and there is a potential sequence for proliferating cell nuclear antigen (PCNA) interaction, we hypothesized that MPG protein could interact with PCNA, a protein involved in repair and replication.	3-methyladenine	49-64	N-methylpurine DNA glycosylase	Homo sapiens	6-9
15713479-6	2005	Since MPG has a role in removing adducts such as 3-methyladenine that block DNA synthesis and there is a potential sequence for proliferating cell nuclear antigen (PCNA) interaction, we hypothesized that MPG protein could interact with PCNA, a protein involved in repair and replication.	3-methyladenine	49-64	N-methylpurine DNA glycosylase	Homo sapiens	204-207
15713479-6	2005	Since MPG has a role in removing adducts such as 3-methyladenine that block DNA synthesis and there is a potential sequence for proliferating cell nuclear antigen (PCNA) interaction, we hypothesized that MPG protein could interact with PCNA, a protein involved in repair and replication.	3-methyladenine	49-64	proliferating cell nuclear antigen	Homo sapiens	236-240
15715672-6	2005	The neuroprotective effect of 3-MA is accompanied by block of cytochrome c (cyt c) release in the cytosol and by inhibition of caspase-3 activation which, in turn, appears to be mediated by cathepsin B, as CA074-Me, a selective inhibitor of this enzyme, fully blocks the processing of pro-caspase-3.	3-methyladenine	30-34	cytochrome c, somatic	Homo sapiens	62-74
15715672-6	2005	The neuroprotective effect of 3-MA is accompanied by block of cytochrome c (cyt c) release in the cytosol and by inhibition of caspase-3 activation which, in turn, appears to be mediated by cathepsin B, as CA074-Me, a selective inhibitor of this enzyme, fully blocks the processing of pro-caspase-3.	3-methyladenine	30-34	cytochrome c, somatic	Homo sapiens	76-81
15715672-6	2005	The neuroprotective effect of 3-MA is accompanied by block of cytochrome c (cyt c) release in the cytosol and by inhibition of caspase-3 activation which, in turn, appears to be mediated by cathepsin B, as CA074-Me, a selective inhibitor of this enzyme, fully blocks the processing of pro-caspase-3.	3-methyladenine	30-34	caspase 3	Homo sapiens	127-136
15715672-6	2005	The neuroprotective effect of 3-MA is accompanied by block of cytochrome c (cyt c) release in the cytosol and by inhibition of caspase-3 activation which, in turn, appears to be mediated by cathepsin B, as CA074-Me, a selective inhibitor of this enzyme, fully blocks the processing of pro-caspase-3.	3-methyladenine	30-34	cathepsin B	Homo sapiens	190-201
15715672-6	2005	The neuroprotective effect of 3-MA is accompanied by block of cytochrome c (cyt c) release in the cytosol and by inhibition of caspase-3 activation which, in turn, appears to be mediated by cathepsin B, as CA074-Me, a selective inhibitor of this enzyme, fully blocks the processing of pro-caspase-3.	3-methyladenine	30-34	caspase 3	Homo sapiens	285-298
15651853-1	2005	The human 3-methyladenine (AAG, ANPG, MPG) DNA glycosylase excises alkylated purines from DNA.	3-methyladenine	10-25	N-methylpurine DNA glycosylase	Homo sapiens	27-30
15651853-1	2005	The human 3-methyladenine (AAG, ANPG, MPG) DNA glycosylase excises alkylated purines from DNA.	3-methyladenine	10-25	N-methylpurine DNA glycosylase	Homo sapiens	32-36
15651853-1	2005	The human 3-methyladenine (AAG, ANPG, MPG) DNA glycosylase excises alkylated purines from DNA.	3-methyladenine	10-25	N-methylpurine DNA glycosylase	Homo sapiens	38-41
15651853-5	2005	The ability of purified wild-type and AAG variants to remove 3-methyladenine and 7-methylguanine, the two most abundant adducts produced by methyl methanesulfonate, was also determined.	3-methyladenine	61-76	N-methylpurine DNA glycosylase	Homo sapiens	38-41
15651853-6	2005	The N169D AAG variant displayed a approximately 100-fold lower activity for 3-methyladenine as compared to wild-type and did not detectably remove 7-methylguanine.	3-methyladenine	76-91	N-methylpurine DNA glycosylase	Homo sapiens	10-13
15651853-9	2005	In contrast, the N169A and N169S AAG variants displayed approximately 30-fold lower activity for 3-methyladenine and 7-methylguanine.	3-methyladenine	97-112	N-methylpurine DNA glycosylase	Homo sapiens	33-36
15558033-5	2004	This non-apoptotic death of double knockout cells was suppressed by inhibitors of autophagy, including 3-methyl adenine, was dependent on autophagic proteins APG5 and Beclin 1 (capable of binding to Bcl-2/Bcl-x(L)), and was also modulated by Bcl-x(L).	3-methyladenine	103-119	beclin 1, autophagy related	Mus musculus	167-175
15558033-5	2004	This non-apoptotic death of double knockout cells was suppressed by inhibitors of autophagy, including 3-methyl adenine, was dependent on autophagic proteins APG5 and Beclin 1 (capable of binding to Bcl-2/Bcl-x(L)), and was also modulated by Bcl-x(L).	3-methyladenine	103-119	B cell leukemia/lymphoma 2	Mus musculus	199-204
15558033-5	2004	This non-apoptotic death of double knockout cells was suppressed by inhibitors of autophagy, including 3-methyl adenine, was dependent on autophagic proteins APG5 and Beclin 1 (capable of binding to Bcl-2/Bcl-x(L)), and was also modulated by Bcl-x(L).	3-methyladenine	103-119	BCL2-like 1	Mus musculus	205-213
15558033-5	2004	This non-apoptotic death of double knockout cells was suppressed by inhibitors of autophagy, including 3-methyl adenine, was dependent on autophagic proteins APG5 and Beclin 1 (capable of binding to Bcl-2/Bcl-x(L)), and was also modulated by Bcl-x(L).	3-methyladenine	103-119	BCL2-like 1	Mus musculus	242-250
15135729-3	2004	The present study examines the role of the BER enzyme 3-alkyladenine DNA glycosylase (AAG) and the NER protein xeroderma pigmentosum group A (XPA) in protecting cerebellar neurons and astrocytes from chloroacetaldehyde (CAA) or the alkylating agent 3-methyllexitropsin (Me-Lex), which produce ethenobases or 3-methyladenine (3-MeA), respectively.	3-methyladenine	308-323	xeroderma pigmentosum, complementation group A	Mus musculus	142-145
15135729-3	2004	The present study examines the role of the BER enzyme 3-alkyladenine DNA glycosylase (AAG) and the NER protein xeroderma pigmentosum group A (XPA) in protecting cerebellar neurons and astrocytes from chloroacetaldehyde (CAA) or the alkylating agent 3-methyllexitropsin (Me-Lex), which produce ethenobases or 3-methyladenine (3-MeA), respectively.	3-methyladenine	325-330	xeroderma pigmentosum, complementation group A	Mus musculus	142-145
15134433-2	2004	We observed that a mutant strain defective in Mag1, the glycosylase that excises 3-MeA in the initial step of base excision repair (BER) to generate an abasic site, is significantly more sensitive to the toxicity of Me-lex with respect to wild type but shows only a marginal increase in mutagenicity.	3-methyladenine	81-86	DNA-3-methyladenine glycosylase II	Saccharomyces cerevisiae S288C	46-50
15033478-5	2004	The results suggest that the effect of 3-MA is restricted to the retrieval of MPR300 from early/recycling endosomes.	3-methyladenine	39-43	insulin like growth factor 2 receptor	Homo sapiens	78-84
14713959-8	2004	When autophagy was prevented at an early stage by 3-methyladenine, a phosphatidylinositol 3-phosphate kinase inhibitor, not only the characteristic pattern of LC3 localization, but also the antitumor effect of TMZ was suppressed.	3-methyladenine	50-65	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	159-162
14871963-11	2004	The underlying mechanism is probably a shift of the cytotoxic locus of temozolomide to N(7)-methylguanine and N(3)-methyladenine, which are repaired by the base excision repair pathway in which PARP-1 actively participates.	3-methyladenine	110-128	poly(ADP-ribose) polymerase 1	Homo sapiens	194-200
12868068-8	2003	Both cell viability and the increase in alpha-synuclein expression are prevented by antioxidants; by the specific inhibitors of p38 and SAPK/JNK, SB203580 and SP600125, respectively; and by the inhibitor of autophagy 3-methyladenine.	3-methyladenine	217-232	synuclein alpha	Homo sapiens	40-55
12792883-6	2003	However, the cytotoxicity of endostatin was significantly reduced by 3-methyladenine (a specific inhibitor of autophagy) and serine and cysteine lysosomal protease inhibitors (leupeptin and aprotinin).	3-methyladenine	69-84	collagen type XVIII alpha 1 chain	Homo sapiens	29-39
12951440-7	2003	The formation of autophagic vacuoles induced by c-Myc was completely blocked by a specific inhibitor of autophagosome formation, 3-methyladenine.	3-methyladenine	129-144	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	48-53
12488460-5	2003	Compounds affecting the pH of intracellular acidic compartments, those interfering with the intracellular vesicular transport as well as inhibition of the fusion between late endosomes and lysosomes by temperature block or 3-methyladenine, hampered the conversion of TPP I proenzyme into the mature form, suggesting that this process takes place in lysosomal compartments.	3-methyladenine	223-238	tripeptidyl peptidase 1	Homo sapiens	267-272
12566303-2	2003	The short-patch BER pathway, beginning with the simple glycosylase N-methylpurine DNA glycosylase (MPG), is responsible for the removal of damaged bases such as 3-methyladenine and 1,N(6)-ethenoadenine from the DNA after alkylation or oxidative DNA damage.	3-methyladenine	161-176	N-methylpurine DNA glycosylase	Homo sapiens	67-97
12566303-2	2003	The short-patch BER pathway, beginning with the simple glycosylase N-methylpurine DNA glycosylase (MPG), is responsible for the removal of damaged bases such as 3-methyladenine and 1,N(6)-ethenoadenine from the DNA after alkylation or oxidative DNA damage.	3-methyladenine	161-176	N-methylpurine DNA glycosylase	Homo sapiens	99-102
12453151-5	2002	Treatment with phosphoinositide 3(PI3)-kinase inhibitors wortmannin, LY294002 and 3-methyladenine (known to inhibit the autophagic response in interphase cells) rescued autophagy in mitotic cells without inducing reassembly of vesiculated ER and Golgi compartments.	3-methyladenine	82-97	peptidase inhibitor 3	Homo sapiens	34-37