PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24726364-4	2014	Overexpression of the glucose transporter GLUT1 in myeloid cells caused increased glycolysis and flux through the pentose phosphate pathway but did not induce cytokines.	Pentosephosphates	114-131	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	42-47
24718268-6	2014	Notably, the pentose phosphate pathway was facilitated with marked up-regulation of glucose-6-phosphate dehydrogenase, a rete-limiting enzyme, with actual increase in NADPH.	Pentosephosphates	13-30	glucose-6-phosphate dehydrogenase	Homo sapiens	84-117
24718268-6	2014	Notably, the pentose phosphate pathway was facilitated with marked up-regulation of glucose-6-phosphate dehydrogenase, a rete-limiting enzyme, with actual increase in NADPH.	Pentosephosphates	13-30	2,4-dienoyl-CoA reductase 1	Homo sapiens	167-172
24637073-1	2014	Glucose-6-phosphate dehydrogenase (G6PDH) is an essential enzyme involved in the first reaction of the oxidative branch of the pentose phosphate pathway (PPP).	Pentosephosphates	127-144	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
24637073-1	2014	Glucose-6-phosphate dehydrogenase (G6PDH) is an essential enzyme involved in the first reaction of the oxidative branch of the pentose phosphate pathway (PPP).	Pentosephosphates	127-144	glucose-6-phosphate dehydrogenase	Homo sapiens	35-40
24647116-4	2014	In the latter case, Nrf2 inhibits lipogenesis, supports beta-oxidation of fatty acids, facilitates flux through the pentose phosphate pathway, and increases NADPH regeneration and purine biosynthesis; these observations suggest Nrf2 directs metabolic reprogramming during stress.	Pentosephosphates	116-133	NFE2 like bZIP transcription factor 2	Homo sapiens	20-24
24647116-4	2014	In the latter case, Nrf2 inhibits lipogenesis, supports beta-oxidation of fatty acids, facilitates flux through the pentose phosphate pathway, and increases NADPH regeneration and purine biosynthesis; these observations suggest Nrf2 directs metabolic reprogramming during stress.	Pentosephosphates	116-133	NFE2 like bZIP transcription factor 2	Homo sapiens	228-232
24633012-0	2014	Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway.	Pentosephosphates	73-90	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	23-29
24666435-6	2014	RESULTS: Despite the defect in the pentose phosphate pathway caused by siRNA knockdown of TKT, the survived UM1 or UM2 cells utilized more glucose and glutamine and secreted a significantly higher amount of lactate than the cells transferred with control siRNA.	Pentosephosphates	35-52	transketolase	Homo sapiens	90-93
24633012-4	2014	HO-1 induction or CO results in reduced methylation of PFKFB3 in varied cancer cells to suppress F-2,6-BP, shifting glucose utilization from glycolysis toward the pentose phosphate pathway.	Pentosephosphates	163-180	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	55-61
24492615-8	2014	Cellular bioenergetics analysis, metabolomics, and radiotracer studies demonstrated that GLUT1 overexpression resulted in elevated glucose uptake and metabolism, increased pentose phosphate pathway intermediates, with a complimentary reduction in cellular oxygen consumption rates.	Pentosephosphates	172-189	solute carrier family 2 member 1	Homo sapiens	89-94
24328790-4	2014	It was identified as TKL (transketolase), an essential enzyme of both the Calvin-Benson-Bassham cycle and the oxidative pentose phosphate pathway.	Pentosephosphates	120-137	Transketolase	Arabidopsis thaliana	21-24
23916856-5	2014	Transcript analysis further revealed that besides the pentose phosphate pathway genes TKL1 and TAL1, ADH7 was also upregulated in response to furfural stress, which resulted in higher ethanol production compared to the TAL-expressing strain.	Pentosephosphates	54-71	transketolase TKL1	Saccharomyces cerevisiae S288C	86-90
23916856-5	2014	Transcript analysis further revealed that besides the pentose phosphate pathway genes TKL1 and TAL1, ADH7 was also upregulated in response to furfural stress, which resulted in higher ethanol production compared to the TAL-expressing strain.	Pentosephosphates	54-71	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1	Saccharomyces cerevisiae S288C	95-99
23916856-5	2014	Transcript analysis further revealed that besides the pentose phosphate pathway genes TKL1 and TAL1, ADH7 was also upregulated in response to furfural stress, which resulted in higher ethanol production compared to the TAL-expressing strain.	Pentosephosphates	54-71	NADP-dependent alcohol dehydrogenase	Saccharomyces cerevisiae S288C	101-105
24576095-1	2014	TIGAR [TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator] protein is known for its ability to inhibit glycolysis, shifting glucose consumption towards the pentose phosphate pathway to promote antioxidant protection of cancer cells.	Pentosephosphates	173-190	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	0-5
24576095-1	2014	TIGAR [TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator] protein is known for its ability to inhibit glycolysis, shifting glucose consumption towards the pentose phosphate pathway to promote antioxidant protection of cancer cells.	Pentosephosphates	173-190	tumor protein p53	Homo sapiens	7-11
24066844-3	2014	The pentose phosphate pathway controlled by glucose- 6-phosphate dehydrogenase (G6PD) has been appreciated largely to its role as a provider of reducing power and ribose phosphate to the cell for maintenance of redox balance and biosynthesis of nucleotides and lipids.	Pentosephosphates	4-21	glucose-6-phosphate dehydrogenase	Homo sapiens	44-78
24066844-3	2014	The pentose phosphate pathway controlled by glucose- 6-phosphate dehydrogenase (G6PD) has been appreciated largely to its role as a provider of reducing power and ribose phosphate to the cell for maintenance of redox balance and biosynthesis of nucleotides and lipids.	Pentosephosphates	4-21	glucose-6-phosphate dehydrogenase	Homo sapiens	80-84
24176786-6	2014	Particularly, functional analysis of Rag2(ko) mice gut microbiota proteins revealed the presence of abundant glutathione, riboflavin metabolism and pentose phosphate pathway components, possibly related to genetic background.	Pentosephosphates	148-165	recombination activating gene 2	Mus musculus	37-41
24405865-1	2014	BACKGROUND: Transketolase (TKT) is a key enzyme of the pentose phosphate pathway (PPP), the Calvin cycle and the ribulose monophosphate (RuMP) cycle.	Pentosephosphates	55-72	tkt	Bacillus methanolicus MGA3	27-30
23934573-2	2014	To address these inconsistent results, we focused the NADPH generation by glucose-6-phosphate dehydrogenase (G6PD), a rate-limiting enzyme of the pentose phosphate pathway (PPP), to titrate reactive oxygen species (ROS) that results in the Deltapsim maintenance.	Pentosephosphates	146-163	glucose-6-phosphate dehydrogenase	Rattus norvegicus	74-107
23934573-2	2014	To address these inconsistent results, we focused the NADPH generation by glucose-6-phosphate dehydrogenase (G6PD), a rate-limiting enzyme of the pentose phosphate pathway (PPP), to titrate reactive oxygen species (ROS) that results in the Deltapsim maintenance.	Pentosephosphates	146-163	glucose-6-phosphate dehydrogenase	Rattus norvegicus	109-113
24296756-4	2014	It was discovered that TSC2-null cells have distinctive autophagy-dependent pentose phosphate pathway (PPP) alterations.	Pentosephosphates	76-93	TSC complex subunit 2	Homo sapiens	23-27
24328790-4	2014	It was identified as TKL (transketolase), an essential enzyme of both the Calvin-Benson-Bassham cycle and the oxidative pentose phosphate pathway.	Pentosephosphates	120-137	Transketolase	Arabidopsis thaliana	26-39
24096100-1	2013	6-Phosphogluconate dehydrogenase (6PGDH), the third enzyme of the pentose phosphate pathway (PPP), is essential for biosyntheses and oxidative stress defence.	Pentosephosphates	66-83	6-phosphogluconate dehydrogenase, decarboxylating	Ovis aries	34-39
24113893-7	2014	In addition, the expression level of ZWF1 in the oxidative pentose phosphate pathway increased significantly in SyBE005, indicating an elevated demand for NADPH from XR.	Pentosephosphates	59-76	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	37-41
24272701-4	2014	We confirm and extend previous work by showing that HEXOKINASE1-mediated oxidative pentose phosphate pathway (OPPP) metabolism is required for Glc-mediated NITRATE TRANSPORTER2.1 (NRT2.1) expression.	Pentosephosphates	83-100	hexokinase 1	Arabidopsis thaliana	52-63
24056970-5	2013	Acrolein inhibited glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity, leading to decreased substrate availability for mitochondrial respiration in RLE-6TN, H441, and pAT2 cells; the reduced GAPDH activity was compensated in pAT2 cells by an increase in the activity of glucose-6-phosphate dehydrogenase, the regulatory control of the pentose phosphate pathway.	Pentosephosphates	342-359	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	19-59
24272701-4	2014	We confirm and extend previous work by showing that HEXOKINASE1-mediated oxidative pentose phosphate pathway (OPPP) metabolism is required for Glc-mediated NITRATE TRANSPORTER2.1 (NRT2.1) expression.	Pentosephosphates	83-100	nitrate transporter 2:1	Arabidopsis thaliana	156-178
24272701-4	2014	We confirm and extend previous work by showing that HEXOKINASE1-mediated oxidative pentose phosphate pathway (OPPP) metabolism is required for Glc-mediated NITRATE TRANSPORTER2.1 (NRT2.1) expression.	Pentosephosphates	83-100	nitrate transporter 2:1	Arabidopsis thaliana	180-186
24056970-5	2013	Acrolein inhibited glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity, leading to decreased substrate availability for mitochondrial respiration in RLE-6TN, H441, and pAT2 cells; the reduced GAPDH activity was compensated in pAT2 cells by an increase in the activity of glucose-6-phosphate dehydrogenase, the regulatory control of the pentose phosphate pathway.	Pentosephosphates	342-359	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	61-66
24190878-0	2013	Cardiac-specific hexokinase 2 overexpression attenuates hypertrophy by increasing pentose phosphate pathway flux.	Pentosephosphates	82-99	hexokinase 2	Rattus norvegicus	17-29
24223971-1	2013	Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway and provides reducing energy to all cells by maintaining redox balance.	Pentosephosphates	64-81	AT695_RS09995	Staphylococcus aureus	0-33
24223971-1	2013	Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway and provides reducing energy to all cells by maintaining redox balance.	Pentosephosphates	64-81	AT695_RS09995	Staphylococcus aureus	35-39
24120946-5	2013	NRX deficiency augmented levels of NADPH and reduced glutathione, two major cellular antioxidants generated through the pentose phosphate pathway.	Pentosephosphates	120-137	nucleoredoxin	Homo sapiens	0-3
24120946-7	2013	These results reveal a novel role of NRX in the regulation of PFK1 activity and in the balance between glycolysis and the pentose phosphate pathway.	Pentosephosphates	122-139	nucleoredoxin	Homo sapiens	37-40
24190878-8	2013	HK2 appears to modulate ROS via the pentose phosphate pathway, as inhibition of glucose-6-phosphate dehydrogenase with dehydroepiandrosterone decreased the ability of HK2 to diminish ROS and hypertrophy.	Pentosephosphates	36-53	hexokinase 2	Rattus norvegicus	0-3
24018234-1	2013	6-Phosphogluconate dehydrogenase (6PGD), the third enzyme in the pentose phosphate pathway, was recently identified as a novel target in human lung cancer.	Pentosephosphates	65-82	phosphogluconate dehydrogenase	Homo sapiens	0-32
24018234-1	2013	6-Phosphogluconate dehydrogenase (6PGD), the third enzyme in the pentose phosphate pathway, was recently identified as a novel target in human lung cancer.	Pentosephosphates	65-82	phosphogluconate dehydrogenase	Homo sapiens	34-38
24190878-8	2013	HK2 appears to modulate ROS via the pentose phosphate pathway, as inhibition of glucose-6-phosphate dehydrogenase with dehydroepiandrosterone decreased the ability of HK2 to diminish ROS and hypertrophy.	Pentosephosphates	36-53	glucose-6-phosphate dehydrogenase	Rattus norvegicus	80-113
24190878-8	2013	HK2 appears to modulate ROS via the pentose phosphate pathway, as inhibition of glucose-6-phosphate dehydrogenase with dehydroepiandrosterone decreased the ability of HK2 to diminish ROS and hypertrophy.	Pentosephosphates	36-53	hexokinase 2	Rattus norvegicus	167-170
24190878-9	2013	CONCLUSIONS: These results suggest that HK2 attenuates cardiac hypertrophy by decreasing ROS accumulation via increased pentose phosphate pathway flux.	Pentosephosphates	120-137	hexokinase 2	Rattus norvegicus	40-43
23718985-2	2013	We hypothesized that the amino sugar glucosamine may block the pentose phosphate pathway via inhibition of the rate-limiting enzyme glucose-6-phosphate dehydrogenase in ESCs and therefore impair decidualization and embryo implantation, thus preventing pregnancy.	Pentosephosphates	63-80	glucose-6-phosphate dehydrogenase	Homo sapiens	132-165
22819458-2	2013	Transketolase-like protein 1 (TKTL1), which has an important role in controlling the nonoxidative pentose-phosphate pathway, is significantly overexpressed in several different tumor entities.	Pentosephosphates	98-115	transketolase like 1	Homo sapiens	30-35
23579026-4	2013	In most animal cells, NADPH is produced predominantly by glucose-6-phosphate dehydrogenase (G6PD) in the oxidative phase of the pentose phosphate pathway and, to a lesser extent, by isocitrate dehydrogenase (IDH) and malic enzyme (ME).	Pentosephosphates	128-145	2,4-dienoyl-CoA reductase 1	Homo sapiens	22-27
23579026-4	2013	In most animal cells, NADPH is produced predominantly by glucose-6-phosphate dehydrogenase (G6PD) in the oxidative phase of the pentose phosphate pathway and, to a lesser extent, by isocitrate dehydrogenase (IDH) and malic enzyme (ME).	Pentosephosphates	128-145	glucose-6-phosphate dehydrogenase	Homo sapiens	57-90
23579026-4	2013	In most animal cells, NADPH is produced predominantly by glucose-6-phosphate dehydrogenase (G6PD) in the oxidative phase of the pentose phosphate pathway and, to a lesser extent, by isocitrate dehydrogenase (IDH) and malic enzyme (ME).	Pentosephosphates	128-145	glucose-6-phosphate dehydrogenase	Homo sapiens	92-96
23811687-5	2013	TAp73 activates the expression of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway (PPP).	Pentosephosphates	108-125	glucose-6-phosphate dehydrogenase	Homo sapiens	34-67
23811687-5	2013	TAp73 activates the expression of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway (PPP).	Pentosephosphates	108-125	glucose-6-phosphate dehydrogenase	Homo sapiens	69-73
22819458-2	2013	Transketolase-like protein 1 (TKTL1), which has an important role in controlling the nonoxidative pentose-phosphate pathway, is significantly overexpressed in several different tumor entities.	Pentosephosphates	98-115	transketolase like 1	Homo sapiens	0-28
23726973-2	2013	TIGAR acts as a fructose-2,6-bisphosphatase, potentially promoting the pentose phosphate pathway to produce NADPH for antioxidant function and ribose-5-phosphate for nucleotide synthesis.	Pentosephosphates	71-88	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	0-5
23921124-2	2013	Using an integrated genomics and 13C-based targeted tracer fate association (TTFA) study, we found that NRF2 regulates miR-1 and miR-206 to direct carbon flux toward the pentose phosphate pathway (PPP) and the tricarboxylic acid (TCA) cycle, reprogramming glucose metabolism.	Pentosephosphates	170-187	nuclear factor, erythroid derived 2, like 2	Mus musculus	104-108
23921124-2	2013	Using an integrated genomics and 13C-based targeted tracer fate association (TTFA) study, we found that NRF2 regulates miR-1 and miR-206 to direct carbon flux toward the pentose phosphate pathway (PPP) and the tricarboxylic acid (TCA) cycle, reprogramming glucose metabolism.	Pentosephosphates	170-187	microRNA 206	Mus musculus	129-136
24024172-4	2013	Upon Nrf2 activation glucose is preferentially metabolized through the pentose phosphate pathway with increased production of NADPH.	Pentosephosphates	71-88	NFE2 like bZIP transcription factor 2	Homo sapiens	5-9
24024172-5	2013	Interference with the supply of glucose or the pentose phosphate pathway and NADPH generation not only hampers Nrf2-mediated detoxification of reactive oxygen species on the enzyme level but also Nrf2-initiated expression of antioxidant defense proteins, such as glutathione reductase and heme-oxygenase1.	Pentosephosphates	47-64	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
24024172-5	2013	Interference with the supply of glucose or the pentose phosphate pathway and NADPH generation not only hampers Nrf2-mediated detoxification of reactive oxygen species on the enzyme level but also Nrf2-initiated expression of antioxidant defense proteins, such as glutathione reductase and heme-oxygenase1.	Pentosephosphates	47-64	NFE2 like bZIP transcription factor 2	Homo sapiens	196-200
24024172-5	2013	Interference with the supply of glucose or the pentose phosphate pathway and NADPH generation not only hampers Nrf2-mediated detoxification of reactive oxygen species on the enzyme level but also Nrf2-initiated expression of antioxidant defense proteins, such as glutathione reductase and heme-oxygenase1.	Pentosephosphates	47-64	glutathione-disulfide reductase	Homo sapiens	263-284
24024172-5	2013	Interference with the supply of glucose or the pentose phosphate pathway and NADPH generation not only hampers Nrf2-mediated detoxification of reactive oxygen species on the enzyme level but also Nrf2-initiated expression of antioxidant defense proteins, such as glutathione reductase and heme-oxygenase1.	Pentosephosphates	47-64	heme oxygenase 1	Homo sapiens	289-304
24024172-6	2013	We conclude that the Nrf2-dependent protection against oxidative stress relies on an intact pentose phosphate pathway and that there is crosstalk between metabolism and detoxification already at the level of gene expression in mammalian cells.	Pentosephosphates	92-109	NFE2 like bZIP transcription factor 2	Homo sapiens	21-25
23885364-1	2010	PKM2 is directly oxidized on Cys(358) to inhibit its catalytic activity, which allows for diversion of glucose-6-phosphate into the pentose phosphate pathway.	Pentosephosphates	132-149	pyruvate kinase M1/2	Homo sapiens	0-4
23594085-8	2013	Interestingly, ECG inhibited the activity of transketolase and glucose-6-phosphate dehydrogenase, the key enzymes of the pentose phosphate pathway.	Pentosephosphates	121-138	transketolase	Homo sapiens	45-58
23594085-8	2013	Interestingly, ECG inhibited the activity of transketolase and glucose-6-phosphate dehydrogenase, the key enzymes of the pentose phosphate pathway.	Pentosephosphates	121-138	glucose-6-phosphate dehydrogenase	Homo sapiens	63-96
23416042-0	2013	Brain energy metabolism in glutamate-receptor activation and excitotoxicity: role for APC/C-Cdh1 in the balance glycolysis/pentose phosphate pathway.	Pentosephosphates	123-140	cadherin 1	Homo sapiens	92-96
23376541-1	2013	Extraintestinal pathogenic Escherichia coli (ExPEC) contain tktA and tktB which code for transketolases involved in the pentose phosphate pathway.	Pentosephosphates	120-137	transketolase 1	Escherichia coli str. K-12 substr. MG1655	60-64
23376541-1	2013	Extraintestinal pathogenic Escherichia coli (ExPEC) contain tktA and tktB which code for transketolases involved in the pentose phosphate pathway.	Pentosephosphates	120-137	transketolase 2	Escherichia coli str. K-12 substr. MG1655	69-73
23670538-5	2013	Downstream steps, which involve the purine nucleoside phosphorylase, Pnp1, and pyrimidine nucleoside hydrolase, Urh1, funnel ribose into the nonoxidative pentose phosphate pathway.	Pentosephosphates	154-171	purine-nucleoside phosphorylase	Saccharomyces cerevisiae S288C	69-73
23670538-5	2013	Downstream steps, which involve the purine nucleoside phosphorylase, Pnp1, and pyrimidine nucleoside hydrolase, Urh1, funnel ribose into the nonoxidative pentose phosphate pathway.	Pentosephosphates	154-171	trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase	Saccharomyces cerevisiae S288C	112-116
23238294-6	2013	Adiponectin also reversed induction of the pentose phosphate pathway by HFD.	Pentosephosphates	43-60	adiponectin, C1Q and collagen domain containing	Mus musculus	0-11
23400775-2	2013	We found previously that increased carbon flux from glucose-6-phosphate (G6P) through the pentose phosphate pathway in egg extracts maintains NADPH levels and calcium/calmodulin regulated protein kinase II (CaMKII) activity to phosphorylate caspase 2 and suppress cell death pathways.	Pentosephosphates	90-107	calcium/calmodulin dependent protein kinase (CaM kinase) II alpha S homeolog	Xenopus laevis	207-213
23400775-2	2013	We found previously that increased carbon flux from glucose-6-phosphate (G6P) through the pentose phosphate pathway in egg extracts maintains NADPH levels and calcium/calmodulin regulated protein kinase II (CaMKII) activity to phosphorylate caspase 2 and suppress cell death pathways.	Pentosephosphates	90-107	caspase 2 L homeolog	Xenopus laevis	241-250
23282133-8	2013	Inhibition of the pentose phosphate pathway by trans-dehydroepiandrosterone (DHEA) suppressed ribose 5-phosphate levels and production of reduced glutathione, as well as insulin secretion in INS-1 832/13 beta-cells and rat islets without affecting ATP production.	Pentosephosphates	18-35	insulin 1	Rattus norvegicus	191-196
23023104-1	2013	Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of the pentose phosphate pathway, converting glucose-6-phosphate to 6-phosphoglucono-delta-lactone with parallel reduction of NADP(+).	Pentosephosphates	66-83	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
23534950-1	2013	We review here some recent data about Glucose-6-phosphate dehydrogenase (G6PD), the housekeeping X-linked gene encoding the first enzyme of the pentose phosphate pathway (PPP), a NADPH-producing dehydrogenase.	Pentosephosphates	144-161	glucose-6-phosphate dehydrogenase	Homo sapiens	38-71
23534950-1	2013	We review here some recent data about Glucose-6-phosphate dehydrogenase (G6PD), the housekeeping X-linked gene encoding the first enzyme of the pentose phosphate pathway (PPP), a NADPH-producing dehydrogenase.	Pentosephosphates	144-161	glucose-6-phosphate dehydrogenase	Homo sapiens	73-77
23534950-1	2013	We review here some recent data about Glucose-6-phosphate dehydrogenase (G6PD), the housekeeping X-linked gene encoding the first enzyme of the pentose phosphate pathway (PPP), a NADPH-producing dehydrogenase.	Pentosephosphates	144-161	2,4-dienoyl-CoA reductase 1	Homo sapiens	179-184
23023104-1	2013	Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of the pentose phosphate pathway, converting glucose-6-phosphate to 6-phosphoglucono-delta-lactone with parallel reduction of NADP(+).	Pentosephosphates	66-83	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
24280180-2	2013	p53 represses metabolic pathways that support tumor development (such as glycolysis and the pentose phosphate pathway (PPP)) and enhances metabolic pathways that are considered counter-tumorigenic such as fatty acid oxidation.	Pentosephosphates	92-109	tumor protein p53	Homo sapiens	0-3
22851446-5	2013	The triose substrate of GAPDH is actually a product of several important metabolic pathways: stage one of glycolysis, fructose catabolism, pentose phosphate pathway and glycerol metabolism.	Pentosephosphates	139-156	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	24-29
23390344-1	2013	Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme in the pentose phosphate pathway (PPP) that plays an important role in protecting cells from oxidative damage by producing NADPH and reduced glutathione.	Pentosephosphates	61-78	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
23390344-1	2013	Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme in the pentose phosphate pathway (PPP) that plays an important role in protecting cells from oxidative damage by producing NADPH and reduced glutathione.	Pentosephosphates	61-78	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
22997160-8	2013	Moreover, Sca-1(pos) CPCs isolated from hearts of diabetic mice displayed reduced activity of key enzymes of the pentose phosphate pathway, glucose-6-phosphate dehydrogenase (G6PD), and transketolase, increased levels of superoxide and advanced glucose end-products (AGE), and inhibition of the Akt/Pim-1/Bcl-2 signalling pathway.	Pentosephosphates	113-130	lymphocyte antigen 6 complex, locus A	Mus musculus	10-15
23970950-1	2013	Uroporphyrinogen decarboxylase (Hem12p) and transketolase (Tkl1p) are key mediators of two critical processes within the cell, heme biosynthesis, and the nonoxidative part of the pentose phosphate pathway (PPP).	Pentosephosphates	179-196	uroporphyrinogen decarboxylase HEM12	Saccharomyces cerevisiae S288C	32-38
22885693-6	2013	Based on the obtained results, we created a new pDNA production strain starting from MG1655 by knocking out the pgi gene in order to redirect carbon flux to the pentose phosphate pathway, enhance nucleotide synthesis, and, consequently, increase pDNA production.	Pentosephosphates	161-178	glucose-6-phosphate isomerase	Escherichia coli str. K-12 substr. MG1655	112-115
23970950-1	2013	Uroporphyrinogen decarboxylase (Hem12p) and transketolase (Tkl1p) are key mediators of two critical processes within the cell, heme biosynthesis, and the nonoxidative part of the pentose phosphate pathway (PPP).	Pentosephosphates	179-196	transketolase TKL1	Saccharomyces cerevisiae S288C	59-64
23185017-1	2012	The p53-inducible protein TIGAR (Tp53-induced Glycolysis and Apoptosis Regulator) functions as a fructose-2,6-bisphosphatase (Fru-2,6-BPase), and through promotion of the pentose phosphate pathway, increases NADPH production to help limit reactive oxygen species (ROS).	Pentosephosphates	171-188	tumor protein p53	Homo sapiens	4-7
23596569-8	2013	While the role of p53 in cancer cell metabolism in arresting glycolysis and inhibition of pentose phosphate pathway has come to be recognized, there are confusions in the literature on the role of FoxO and that of rictor.	Pentosephosphates	90-107	tumor protein p53	Homo sapiens	18-21
23185017-1	2012	The p53-inducible protein TIGAR (Tp53-induced Glycolysis and Apoptosis Regulator) functions as a fructose-2,6-bisphosphatase (Fru-2,6-BPase), and through promotion of the pentose phosphate pathway, increases NADPH production to help limit reactive oxygen species (ROS).	Pentosephosphates	171-188	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	26-31
23185017-1	2012	The p53-inducible protein TIGAR (Tp53-induced Glycolysis and Apoptosis Regulator) functions as a fructose-2,6-bisphosphatase (Fru-2,6-BPase), and through promotion of the pentose phosphate pathway, increases NADPH production to help limit reactive oxygen species (ROS).	Pentosephosphates	171-188	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	33-80
23177934-7	2012	Metabolic analyses indicated that glycogen degradation by PYGL is important for the optimal function of the pentose phosphate pathway.	Pentosephosphates	108-125	glycogen phosphorylase L	Homo sapiens	58-62
22682085-3	2012	Insulin resistance is important in various states such as starvation, immune activation, growth and cancer, to spare glucose for different biosynthetic purposes such as the production of NADPH, nucleotides in the pentose phosphate pathway and oxaloacetate for anaplerosis.	Pentosephosphates	213-230	insulin	Homo sapiens	0-7
23015612-1	2012	Recent studies have shown that glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme for the pentose phosphate pathway, was involved in insulin resistance via reduced nicotinamide adenine dinucleotide phosphate, while the roles of pentose were not examined.	Pentosephosphates	106-123	glucose-6-phosphate dehydrogenase	Rattus norvegicus	31-64
23015612-1	2012	Recent studies have shown that glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme for the pentose phosphate pathway, was involved in insulin resistance via reduced nicotinamide adenine dinucleotide phosphate, while the roles of pentose were not examined.	Pentosephosphates	106-123	glucose-6-phosphate dehydrogenase	Rattus norvegicus	66-70
23114090-5	2012	High incorporation of glucose and an enhancement of the pentose phosphate pathway were observed in ME1-repressed cells.	Pentosephosphates	56-73	malic enzyme 1	Homo sapiens	99-102
23071360-5	2012	The main focus will be on HIF-1-controlled protection of the vasculature postirradiation and on HIF-1 regulation of glycolysis and the pentose phosphate pathway.	Pentosephosphates	135-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-101
23174755-3	2012	NRF2 was also shown to the pentose phosphate pathway and glutaminolysis, which promotes purine synthesis for supporting rapid proliferation and glutathione for providing anti-oxidative stress protection.	Pentosephosphates	27-44	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
22510381-2	2012	Transaldolase is an enzyme of the reversible part of the pentose phosphate pathway.	Pentosephosphates	57-74	transaldolase 1	Homo sapiens	0-13
22421967-5	2012	NMDAR-mediated increase in PFKFB3 yielded neurons having a higher glycolysis and lower pentose-phosphate pathway (PPP); this led to oxidative stress and apoptotic neuronal death that was counteracted by overexpressing glucose-6-phosphate dehydrogenase, the rate-limiting enzyme of the PPP.	Pentosephosphates	87-104	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	27-33
23801924-1	2012	SUMMARY: G6PD catalyzes the first, pace-making reaction of pentosephosphate cycle (PPC) which produces NADPH.	Pentosephosphates	59-75	glucose-6-phosphate dehydrogenase	Homo sapiens	9-13
22402261-8	2012	The data presented here provide a case study that such inactivation of SBPase caused by carbonyl modification may be a kind of adaptation for plants to restrict the operation of the reductive pentose phosphate pathway under stress conditions.	Pentosephosphates	192-209	sedoheptulose-bisphosphatase	Arabidopsis thaliana	71-77
22610605-3	2012	Spc1/Sty1, a mitogen/stress-activated protein kinase homologous to human p38 and Saccharomyces cerevisiae Hog1, controls many of these changes, including enzymes of the oxidative phase of the pentose phosphate pathway and trehalose metabolism.	Pentosephosphates	192-209	signal peptidase complex subunit 1	Homo sapiens	0-4
22610605-3	2012	Spc1/Sty1, a mitogen/stress-activated protein kinase homologous to human p38 and Saccharomyces cerevisiae Hog1, controls many of these changes, including enzymes of the oxidative phase of the pentose phosphate pathway and trehalose metabolism.	Pentosephosphates	192-209	mitogen-activated protein kinase 14	Homo sapiens	73-76
22610605-3	2012	Spc1/Sty1, a mitogen/stress-activated protein kinase homologous to human p38 and Saccharomyces cerevisiae Hog1, controls many of these changes, including enzymes of the oxidative phase of the pentose phosphate pathway and trehalose metabolism.	Pentosephosphates	192-209	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	106-110
22535206-6	2012	Cancer cells, as opposed to near-normal MCF-10A cells, exhibited significantly increased expression of key energy metabolic pathway enzymes (FBP1, IDH2, and G6PD) that are known to redirect cellular metabolism and increase carbon flux through the pentose phosphate pathway.	Pentosephosphates	247-264	fructose-bisphosphatase 1	Homo sapiens	141-145
22535206-6	2012	Cancer cells, as opposed to near-normal MCF-10A cells, exhibited significantly increased expression of key energy metabolic pathway enzymes (FBP1, IDH2, and G6PD) that are known to redirect cellular metabolism and increase carbon flux through the pentose phosphate pathway.	Pentosephosphates	247-264	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	147-151
22535206-6	2012	Cancer cells, as opposed to near-normal MCF-10A cells, exhibited significantly increased expression of key energy metabolic pathway enzymes (FBP1, IDH2, and G6PD) that are known to redirect cellular metabolism and increase carbon flux through the pentose phosphate pathway.	Pentosephosphates	247-264	glucose-6-phosphate dehydrogenase	Homo sapiens	157-161
22639416-4	2012	Plasmodium parasites are highly dependent on glucose and very sensitive to oxidative stress; two observations that drew interest to the pentose phosphate pathway (PPP) with its key enzyme glucose-6-phosphate dehydrogenase (G6PD).	Pentosephosphates	136-153	glucose-6-phosphate dehydrogenase	Homo sapiens	223-227
22677172-1	2012	We show that knockdown of 6-phosphogluconate dehydrogenase (6PGD) of the pentose phosphate pathway (PPP) inhibits growth of lung cancer cells by senescence induction.	Pentosephosphates	73-90	phosphogluconate dehydrogenase	Homo sapiens	26-58
22677172-1	2012	We show that knockdown of 6-phosphogluconate dehydrogenase (6PGD) of the pentose phosphate pathway (PPP) inhibits growth of lung cancer cells by senescence induction.	Pentosephosphates	73-90	phosphogluconate dehydrogenase	Homo sapiens	60-64
22580330-1	2012	NADPH derived from glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, has been implicated not only to promote reduced glutathione (GSH) but also enhance oxidative stress in specific cellular conditions.	Pentosephosphates	93-110	glucose-6-phosphate dehydrogenase	Rattus norvegicus	54-58
22661920-6	2012	The results show that the metabolic profile associated with the depletion of CDK4, CDK6 and CDK2 coincides with the metabolic changes induced by calcein AM on HCT116 cells, thus confirming that the inhibition of CDK4 and CDK6 disrupts the balance between the oxidative and non-oxidative branches of the pentose phosphate pathway.	Pentosephosphates	303-320	cyclin dependent kinase 4	Homo sapiens	77-81
22580330-1	2012	NADPH derived from glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, has been implicated not only to promote reduced glutathione (GSH) but also enhance oxidative stress in specific cellular conditions.	Pentosephosphates	93-110	glucose-6-phosphate dehydrogenase	Rattus norvegicus	19-52
22682218-3	2012	(2012) show that the sedoheptulose kinase CARKL is required for metabolic reprogramming in activated macrophages and provide evidence that changes in glucose metabolism and the pentose phosphate pathway (PPP) influences macrophage polarization.	Pentosephosphates	177-194	sedoheptulokinase	Homo sapiens	42-47
22682222-5	2012	Interestingly, CARKL catalyzes an orphan reaction in the pentose phosphate pathway, refocusing cellular metabolism to a high-redox state upon physiological or artificial downregulation.	Pentosephosphates	57-74	sedoheptulokinase	Homo sapiens	15-20
22579386-2	2012	Overexpression of TAL1 and TKL1, the major transaldolase and transketolase genes, increases the flux from the pentose phosphate pathway into the glycolytic pathway.	Pentosephosphates	110-127	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1	Saccharomyces cerevisiae S288C	18-22
22579386-2	2012	Overexpression of TAL1 and TKL1, the major transaldolase and transketolase genes, increases the flux from the pentose phosphate pathway into the glycolytic pathway.	Pentosephosphates	110-127	transketolase TKL1	Saccharomyces cerevisiae S288C	27-31
22579386-11	2012	NQM1 and TKL2 may thus play a physiological role via an effect on the non-oxidative pentose phosphate pathway in the xylose metabolic pathway, although their roles in xylose utilization and fermentation are less important than those of TAL1 and TKL1.	Pentosephosphates	84-101	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1	Saccharomyces cerevisiae S288C	0-4
22579386-11	2012	NQM1 and TKL2 may thus play a physiological role via an effect on the non-oxidative pentose phosphate pathway in the xylose metabolic pathway, although their roles in xylose utilization and fermentation are less important than those of TAL1 and TKL1.	Pentosephosphates	84-101	transketolase TKL2	Saccharomyces cerevisiae S288C	9-13
22579386-11	2012	NQM1 and TKL2 may thus play a physiological role via an effect on the non-oxidative pentose phosphate pathway in the xylose metabolic pathway, although their roles in xylose utilization and fermentation are less important than those of TAL1 and TKL1.	Pentosephosphates	84-101	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1	Saccharomyces cerevisiae S288C	236-240
22579386-11	2012	NQM1 and TKL2 may thus play a physiological role via an effect on the non-oxidative pentose phosphate pathway in the xylose metabolic pathway, although their roles in xylose utilization and fermentation are less important than those of TAL1 and TKL1.	Pentosephosphates	84-101	transketolase TKL1	Saccharomyces cerevisiae S288C	245-249
22816071-0	2012	Function of the pentose phosphate pathway and its key enzyme, transketolase, in the regulation of the meiotic cell cycle in oocytes.	Pentosephosphates	16-33	transketolase	Homo sapiens	62-75
22816071-1	2012	OBJECTIVE: Previously, we identified that transketolase (Tkt), an important enzyme in the pentose phosphate pathway, is highly expressed at 2 hours of spontaneous maturation in oocytes.	Pentosephosphates	90-107	transketolase	Homo sapiens	42-55
22816071-1	2012	OBJECTIVE: Previously, we identified that transketolase (Tkt), an important enzyme in the pentose phosphate pathway, is highly expressed at 2 hours of spontaneous maturation in oocytes.	Pentosephosphates	90-107	transketolase	Homo sapiens	57-60
22816071-7	2012	The modified expression of two enzymes in the pentose phosphate pathway, Prps1 and Rbks, after Tkt RNAi and decreased maturation rates were amended when ribose-5-phosphate was supplemented in the culture medium, suggesting that the Tkt and pentose phosphate pathway are important for the maturation process.	Pentosephosphates	46-63	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	73-78
22816071-7	2012	The modified expression of two enzymes in the pentose phosphate pathway, Prps1 and Rbks, after Tkt RNAi and decreased maturation rates were amended when ribose-5-phosphate was supplemented in the culture medium, suggesting that the Tkt and pentose phosphate pathway are important for the maturation process.	Pentosephosphates	46-63	ribokinase	Homo sapiens	83-87
22816071-7	2012	The modified expression of two enzymes in the pentose phosphate pathway, Prps1 and Rbks, after Tkt RNAi and decreased maturation rates were amended when ribose-5-phosphate was supplemented in the culture medium, suggesting that the Tkt and pentose phosphate pathway are important for the maturation process.	Pentosephosphates	46-63	transketolase	Homo sapiens	95-98
22816071-7	2012	The modified expression of two enzymes in the pentose phosphate pathway, Prps1 and Rbks, after Tkt RNAi and decreased maturation rates were amended when ribose-5-phosphate was supplemented in the culture medium, suggesting that the Tkt and pentose phosphate pathway are important for the maturation process.	Pentosephosphates	46-63	transketolase	Homo sapiens	232-235
22816071-7	2012	The modified expression of two enzymes in the pentose phosphate pathway, Prps1 and Rbks, after Tkt RNAi and decreased maturation rates were amended when ribose-5-phosphate was supplemented in the culture medium, suggesting that the Tkt and pentose phosphate pathway are important for the maturation process.	Pentosephosphates	240-257	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	73-78
22816071-7	2012	The modified expression of two enzymes in the pentose phosphate pathway, Prps1 and Rbks, after Tkt RNAi and decreased maturation rates were amended when ribose-5-phosphate was supplemented in the culture medium, suggesting that the Tkt and pentose phosphate pathway are important for the maturation process.	Pentosephosphates	240-257	ribokinase	Homo sapiens	83-87
22816071-7	2012	The modified expression of two enzymes in the pentose phosphate pathway, Prps1 and Rbks, after Tkt RNAi and decreased maturation rates were amended when ribose-5-phosphate was supplemented in the culture medium, suggesting that the Tkt and pentose phosphate pathway are important for the maturation process.	Pentosephosphates	240-257	transketolase	Homo sapiens	95-98
22816071-8	2012	CONCLUSION: We concluded that Tkt and its associated pentose phosphate pathway play an important role in the MI-MII transition of the oocytes" meiotic cell cycle, but not in the process of GVBD.	Pentosephosphates	53-70	transketolase	Homo sapiens	30-33
22661920-6	2012	The results show that the metabolic profile associated with the depletion of CDK4, CDK6 and CDK2 coincides with the metabolic changes induced by calcein AM on HCT116 cells, thus confirming that the inhibition of CDK4 and CDK6 disrupts the balance between the oxidative and non-oxidative branches of the pentose phosphate pathway.	Pentosephosphates	303-320	cyclin dependent kinase 2	Homo sapiens	92-96
22661920-6	2012	The results show that the metabolic profile associated with the depletion of CDK4, CDK6 and CDK2 coincides with the metabolic changes induced by calcein AM on HCT116 cells, thus confirming that the inhibition of CDK4 and CDK6 disrupts the balance between the oxidative and non-oxidative branches of the pentose phosphate pathway.	Pentosephosphates	303-320	cyclin dependent kinase 4	Homo sapiens	212-216
22661920-6	2012	The results show that the metabolic profile associated with the depletion of CDK4, CDK6 and CDK2 coincides with the metabolic changes induced by calcein AM on HCT116 cells, thus confirming that the inhibition of CDK4 and CDK6 disrupts the balance between the oxidative and non-oxidative branches of the pentose phosphate pathway.	Pentosephosphates	303-320	cyclin dependent kinase 6	Homo sapiens	221-225
22541435-4	2012	Transcriptome and metabolomic analyses indicate that Kras(G12D) serves a vital role in controlling tumor metabolism through stimulation of glucose uptake and channeling of glucose intermediates into the hexosamine biosynthesis and pentose phosphate pathways (PPP).	Pentosephosphates	231-248	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	53-57
22431005-1	2012	Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway.	Pentosephosphates	76-93	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
22431005-1	2012	Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway.	Pentosephosphates	76-93	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
22837861-4	2012	Layered transcriptomic and metabolomic analyses of human pulmonary microvascular endothelial cells (hPMVEC) expressing two different disease-causing mutations in the bone morphogenetic protein receptor type 2 (BMPR2) confirmed previously described increases in aerobic glycolysis but also uncovered significant upregulation of the pentose phosphate pathway, increases in nucleotide salvage and polyamine biosynthesis pathways, decreases in carnitine and fatty acid oxidation pathways, and major impairment of the tricarboxylic acid (TCA) cycle and failure of anaplerosis.	Pentosephosphates	331-348	bone morphogenetic protein receptor type 2	Homo sapiens	166-208
22576206-1	2012	Using a high-throughput short-hairpin RNA library screen targeting 222 metabolic nodes, Ros and colleagues identified 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), a glycolytic enzyme that shunts glucose into the pentose phosphate pathway for NADPH production, as a critical node for the survival of prostate cancer cells.	Pentosephosphates	231-248	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Homo sapiens	118-171
22576206-1	2012	Using a high-throughput short-hairpin RNA library screen targeting 222 metabolic nodes, Ros and colleagues identified 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), a glycolytic enzyme that shunts glucose into the pentose phosphate pathway for NADPH production, as a critical node for the survival of prostate cancer cells.	Pentosephosphates	231-248	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Homo sapiens	173-179
22837861-4	2012	Layered transcriptomic and metabolomic analyses of human pulmonary microvascular endothelial cells (hPMVEC) expressing two different disease-causing mutations in the bone morphogenetic protein receptor type 2 (BMPR2) confirmed previously described increases in aerobic glycolysis but also uncovered significant upregulation of the pentose phosphate pathway, increases in nucleotide salvage and polyamine biosynthesis pathways, decreases in carnitine and fatty acid oxidation pathways, and major impairment of the tricarboxylic acid (TCA) cycle and failure of anaplerosis.	Pentosephosphates	331-348	bone morphogenetic protein receptor type 2	Homo sapiens	210-215
22307140-4	2012	Specifically, we focus on the functions of p53 in regulating aerobic glycolysis, oxidative phosphorylation, the pentose phosphate pathway, fatty acid synthesis and oxidation, and glutamine metabolism, and we discuss the therapeutic strategy whereby p53 helps to prevent malignant progression.	Pentosephosphates	112-129	tumor protein p53	Homo sapiens	43-46
22213464-8	2012	The WE predicts that expression of both HK2 and PKM2 M2 results in a slowing of glucose metabolism through the TCA cycle, thereby forcing the products of glycolysis to be metabolized through the pentose phosphate pathway and to lactic acid.	Pentosephosphates	195-212	hexokinase 2	Sus scrofa	40-43
22566084-5	2012	Furthermore, metabolic flux analysis demonstrated that the over-expression of PGK directed the flux of the pentose phosphate pathway (PPP) towards the glycolysis pathway (EMP), and the expression of PGDH(r) improved the L-serine biosynthesis pathway.	Pentosephosphates	107-124	phosphoglycerate kinase	Corynebacterium glutamicum ATCC 13032	78-81
22287546-12	2012	Inhibition of the pentose phosphate pathway by glucose-6-phosphate dehydrogenase inhibitors and siRNA suppressed ROS generation and monocyte chemotactic factor gene expression induced by both glucose and palmitate.	Pentosephosphates	18-35	glucose-6-phosphate dehydrogenase	Homo sapiens	47-80
22319437-6	2012	The dFBA profiled biologically meaningful dynamic MR-1 metabolisms: 1. the oxidative TCA cycle fluxes increased initially and then decreased in the late growth stage; 2. fluxes in the pentose phosphate pathway and gluconeogenesis were stable in the exponential growth period; and 3. the glyoxylate shunt was up-regulated when acetate became the main carbon source for MR-1 growth.	Pentosephosphates	184-201	Aldolase 1	Drosophila melanogaster	4-8
22083321-1	2012	BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway that provides the majority of NADPH required for lipid biosynthesis.	Pentosephosphates	88-105	glucose-6-phosphate dehydrogenase	Homo sapiens	12-45
22083321-1	2012	BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway that provides the majority of NADPH required for lipid biosynthesis.	Pentosephosphates	88-105	glucose-6-phosphate dehydrogenase	Homo sapiens	47-51
22285204-15	2012	Antioxidant supplementation was noted to increase G6PDH in the pentose phosphate cycle and 18S rRNA in the ribosome.	Pentosephosphates	63-80	glucose-6-phosphate dehydrogenase	Homo sapiens	50-55
22117045-5	2012	In concert with the decrease in TIGAR expression, which regulates the pentose phosphate pathway, treatment with the MUC1-C inhibitor reduced production of NADPH, and in turn glutathione (GSH) levels.	Pentosephosphates	70-87	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	32-37
22117045-5	2012	In concert with the decrease in TIGAR expression, which regulates the pentose phosphate pathway, treatment with the MUC1-C inhibitor reduced production of NADPH, and in turn glutathione (GSH) levels.	Pentosephosphates	70-87	mucin 1, cell surface associated	Homo sapiens	116-120
21835137-5	2012	To identify the exact nature of the metabolite signal required for ChREBP activity in liver, we focused on the importance of G6P synthesis in liver cells, through the modulation of glucose 6-phosphate dehydrogenase (G6PDH) activity, the rate-limiting enzyme of the pentose phosphate pathway in hepatocytes, and in HepG2 cells using both adenoviral and siRNA approaches.	Pentosephosphates	265-282	glucose-6-phosphate dehydrogenase	Homo sapiens	181-214
23166591-9	2012	Pathway analysis and network reconstruction revealed that Tat expression specifically resulted in the nucleolar enrichment of proteins collectively participating in ribosomal biogenesis, protein homeostasis, metabolic pathways including glycolytic, pentose phosphate, nucleotides and amino acids biosynthetic pathways, stress response, T-cell signaling pathways and genome integrity.	Pentosephosphates	249-266	tyrosine aminotransferase	Homo sapiens	58-61
23118983-1	2012	Besides transketolase (TKT), a thiamin-dependent enzyme of the pentose phosphate pathway, the human genome encodes for two closely related transketolase-like proteins, which share a high sequence identity with TKT.	Pentosephosphates	63-80	transketolase	Homo sapiens	8-21
23118983-1	2012	Besides transketolase (TKT), a thiamin-dependent enzyme of the pentose phosphate pathway, the human genome encodes for two closely related transketolase-like proteins, which share a high sequence identity with TKT.	Pentosephosphates	63-80	transketolase	Homo sapiens	139-152
23071515-2	2012	Because 17-ketosteroids are known to inhibit glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway, and to reduce intracellular NADPH levels, we hypothesized that inhibition of G6PD could be a novel signaling mechanism which inhibit I(Ca-L) and, therefore, cardiac contractile function.	Pentosephosphates	119-136	glucose-6-phosphate dehydrogenase 2	Mus musculus	45-78
23071515-2	2012	Because 17-ketosteroids are known to inhibit glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway, and to reduce intracellular NADPH levels, we hypothesized that inhibition of G6PD could be a novel signaling mechanism which inhibit I(Ca-L) and, therefore, cardiac contractile function.	Pentosephosphates	119-136	glucose-6-phosphate dehydrogenase 2	Mus musculus	80-84
22178745-3	2012	Although overproduction of non-oxidative pentose phosphate pathway significantly increased the aerobic-specific growth rate on xylose and slightly improved conversion of xylose to ethanol under oxygen-limited conditions, the elimination of respiration by deleting cytochrome C oxidase subunit IV gene impeded aerobic growth on xylose.	Pentosephosphates	41-58	cytochrome c oxidase subunit IV	Saccharomyces cerevisiae S288C	264-295
22848499-5	2012	This approach generated a signature of seven unique genes including G6PD which encodes the rate-determining enzyme of the pentose phosphate pathway (PPP), glucose-6-phosphate dehydrogenase.	Pentosephosphates	122-139	glucose-6-phosphate dehydrogenase	Homo sapiens	68-72
22848499-5	2012	This approach generated a signature of seven unique genes including G6PD which encodes the rate-determining enzyme of the pentose phosphate pathway (PPP), glucose-6-phosphate dehydrogenase.	Pentosephosphates	122-139	glucose-6-phosphate dehydrogenase	Homo sapiens	155-188
21775727-6	2011	Messenger RNA of genes encoding enzymes in the pentose phosphate pathway and enzyme were low with Nrf2 deficiency and high with Nrf2 activation, indicating that Nrf2 is important for NADPH production.	Pentosephosphates	47-64	nuclear factor, erythroid derived 2, like 2	Mus musculus	98-102
22403640-1	2012	Transketolase is an enzyme involved in a critical step of the non-oxidative branch of the pentose phosphate pathway whose inhibition could lead to new anticancer drugs.	Pentosephosphates	90-107	transketolase	Homo sapiens	0-13
22253711-5	2012	Both Myc and mTOR are known to be activators of the Pentose Phosphate Pathway (PPP).	Pentosephosphates	52-69	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	5-8
22253711-5	2012	Both Myc and mTOR are known to be activators of the Pentose Phosphate Pathway (PPP).	Pentosephosphates	52-69	mechanistic target of rapamycin kinase	Homo sapiens	13-17
21743961-8	2011	Immunoblotting experiment showed that aspirin also acetylated glucose-6-phosphate dehydrogenase and transketolase, both enzymes of pentose phosphate pathway involved in ribonucleotide biosynthesis.	Pentosephosphates	131-148	glucose-6-phosphate dehydrogenase	Homo sapiens	62-95
21743961-8	2011	Immunoblotting experiment showed that aspirin also acetylated glucose-6-phosphate dehydrogenase and transketolase, both enzymes of pentose phosphate pathway involved in ribonucleotide biosynthesis.	Pentosephosphates	131-148	transketolase	Homo sapiens	100-113
22052977-3	2011	This inhibition of PKM2 is required to divert glucose flux into the pentose phosphate pathway and thereby generate sufficient reducing potential for detoxification of ROS.	Pentosephosphates	68-85	pyruvate kinase M1/2	Homo sapiens	19-23
21679161-2	2011	In the present paper we illustrate that a doxorubicin-resistant human colon cancer cell line (HT29-DX), exhibiting decreased doxorubicin accumulation, increased intracellular GSH content, and increased MRP1 and MRP2 expression in comparison with doxorubicin-sensitive HT29 cells, shows increased activity of the PPP (pentose phosphate pathway) and of G6PD (glucose-6-phosphate dehydrogenase).	Pentosephosphates	317-334	ATP binding cassette subfamily C member 2	Homo sapiens	211-215
22219589-4	2011	But known or suspected glucose-6-phosphate dehydrogenase (G6PD) deficiency is a relative contraindication to the use of methylene blue because G6PD is the key enzyme in the formation of NADPH through pentose phosphate pathway and G6PD-deficient individuals generate insufficient NADPH to efficiently reduce methylene blue to leukomethylene blue, which is necessary for the activation of the NADPH-dependent methemoglobin reductase system.	Pentosephosphates	200-217	glucose-6-phosphate dehydrogenase	Homo sapiens	58-62
21775727-6	2011	Messenger RNA of genes encoding enzymes in the pentose phosphate pathway and enzyme were low with Nrf2 deficiency and high with Nrf2 activation, indicating that Nrf2 is important for NADPH production.	Pentosephosphates	47-64	nuclear factor, erythroid derived 2, like 2	Mus musculus	128-132
21775727-6	2011	Messenger RNA of genes encoding enzymes in the pentose phosphate pathway and enzyme were low with Nrf2 deficiency and high with Nrf2 activation, indicating that Nrf2 is important for NADPH production.	Pentosephosphates	47-64	nuclear factor, erythroid derived 2, like 2	Mus musculus	128-132
21376665-0	2011	Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolase.	Pentosephosphates	77-94	transaldolase 1	Homo sapiens	106-119
21684277-4	2011	A decrease in glucose-6-phosphate dehydrogenase activity in HD cybrids further indicated decreased rate of the pentose-phosphate pathway.	Pentosephosphates	111-128	glucose-6-phosphate dehydrogenase	Homo sapiens	14-47
21849056-4	2011	RESULTS: Pentose phosphate pathway (PPP), a vital metabolic pathway for cell cycle progression, was elevated and suppressed by IGF-1 and RSV, respectively in the HT-29 cell line.	Pentosephosphates	9-26	insulin like growth factor 1	Homo sapiens	127-132
21844365-3	2011	We report here that cyanophages carry and express a Calvin cycle inhibitor, CP12, whose host homologue directs carbon flux from the Calvin cycle to the pentose phosphate pathway (PPP).	Pentosephosphates	152-169	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	76-80
21512163-5	2011	EGFR deletion enhanced spontaneous cell death, reduced pentose phosphate pathway activity, disturbed cellular matrix homeostasis (collagen III and fibronectin), and abolished epidermal growth factor sensitivity.	Pentosephosphates	55-72	epidermal growth factor receptor	Mus musculus	0-4
21474354-0	2011	Functional analysis of the 5" flanking region of the human G6PC3 gene: regulation of promoter activity by glucose, pyruvate, AMP kinase and the pentose phosphate pathway.	Pentosephosphates	144-161	glucose-6-phosphatase catalytic subunit 3	Homo sapiens	59-64
21474354-10	2011	Promoter activity was reduced by inhibitors of hexokinase, glyceraldehyde phosphate dehydrogenase and the oxidative branch of the pentose phosphate pathway, but not by a transketolase inhibitor.	Pentosephosphates	130-147	hexokinase 1	Homo sapiens	47-57
21443518-3	2011	In P. falciparum, G6PD is combined with the second enzyme of the pentose phosphate pathway to create a unique bifunctional enzyme named GluPho (glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase).	Pentosephosphates	65-82	glucose-6-phosphate dehydrogenase	Homo sapiens	18-22
21443518-3	2011	In P. falciparum, G6PD is combined with the second enzyme of the pentose phosphate pathway to create a unique bifunctional enzyme named GluPho (glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase).	Pentosephosphates	65-82	glucose-6-phosphate dehydrogenase	Homo sapiens	144-177
21335525-4	2011	Because NADPH can be produced by the oxidative pentose phosphate pathway during the night, NTRC is important to maintain the chloroplast redox homeostasis under light limitation.	Pentosephosphates	47-64	NADPH-dependent thioredoxin reductase C	Arabidopsis thaliana	91-95
21487041-4	2011	mTORC1 activation is sufficient to promote flux through glycolysis and the oxidative branch of the pentose phosphate pathway, as well as to stimulate de novo lipogenesis, all processes that are important in tumor biology.	Pentosephosphates	99-116	CREB regulated transcription coactivator 1	Mus musculus	0-6
22112266-0	2011	Improved oxytetracycline production in Streptomyces rimosus M4018 by metabolic engineering of the G6PDH gene in the pentose phosphate pathway.	Pentosephosphates	116-133	DF17_RS17135	Streptomyces rimosus	98-103
21380594-1	2011	AIMS/HYPOTHESIS: Impaired activity of the pentose phosphate pathway of glucose metabolism caused by hereditary deficiency of its key regulatory enzyme glucose-6-phosphate dehydrogenase (G6PD) has consequences that may worsen or attenuate the course of diabetic complications.	Pentosephosphates	42-59	glucose-6-phosphate dehydrogenase	Homo sapiens	151-184
21380594-1	2011	AIMS/HYPOTHESIS: Impaired activity of the pentose phosphate pathway of glucose metabolism caused by hereditary deficiency of its key regulatory enzyme glucose-6-phosphate dehydrogenase (G6PD) has consequences that may worsen or attenuate the course of diabetic complications.	Pentosephosphates	42-59	glucose-6-phosphate dehydrogenase	Homo sapiens	186-190
20714780-10	2011	Four pentose phosphate pathway (PPP) genes, TKL1, TAL1, RKI1 and RPE1 from S. cerevisiae, were also overexpressed in 424A(LNH-ST).	Pentosephosphates	5-22	ribulose-phosphate 3-epimerase RPE1	Saccharomyces cerevisiae S288C	65-69
21301797-5	2011	Recent studies have found that mTORC1 activation is sufficient to stimulate an increase in glucose uptake, glycolysis, and de novo lipid biosynthesis, which are considered metabolic hallmarks of cancer, as well as the pentose phosphate pathway.	Pentosephosphates	218-235	CREB regulated transcription coactivator 1	Mus musculus	31-37
20558052-5	2011	The combination also reduced the activity of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and transaldolase in the pentose phosphate pathway, a major mechanism for producing NADPH, resulting in a marked decrease in intracellular NADPH levels.	Pentosephosphates	139-156	glucose-6-phosphate dehydrogenase	Homo sapiens	45-78
21336302-3	2011	The tumour suppressor p53 has now been reported to block a metabolic pathway (the pentose phosphate pathway) that diverts glucose away from bioenergetic into biosynthetic routes.	Pentosephosphates	82-99	tumor protein p53	Homo sapiens	22-25
20558052-5	2011	The combination also reduced the activity of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and transaldolase in the pentose phosphate pathway, a major mechanism for producing NADPH, resulting in a marked decrease in intracellular NADPH levels.	Pentosephosphates	139-156	transaldolase 1	Homo sapiens	118-131
21336310-4	2011	Here we show that the tumour suppressor p53, the most frequently mutated gene in human tumours, inhibits the pentose phosphate pathway (PPP).	Pentosephosphates	109-126	tumor protein p53	Homo sapiens	40-43
20649491-1	2011	Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme in the pentose phosphate pathway and a major source of nicotinamide adenine dinucleotide phosphate reduced (NADPH), which regulates numerous enzymatic (including glutathione reductase and NADPH oxidase that, respectively, generates reduced glutathione and reactive oxygen species) reactions involved in various cellular actions, yet its physiological function is seldom investigated.	Pentosephosphates	76-93	glucose-6-phosphate dehydrogenase 2	Mus musculus	0-33
20649491-1	2011	Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme in the pentose phosphate pathway and a major source of nicotinamide adenine dinucleotide phosphate reduced (NADPH), which regulates numerous enzymatic (including glutathione reductase and NADPH oxidase that, respectively, generates reduced glutathione and reactive oxygen species) reactions involved in various cellular actions, yet its physiological function is seldom investigated.	Pentosephosphates	76-93	glucose-6-phosphate dehydrogenase 2	Mus musculus	35-39
20649491-1	2011	Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme in the pentose phosphate pathway and a major source of nicotinamide adenine dinucleotide phosphate reduced (NADPH), which regulates numerous enzymatic (including glutathione reductase and NADPH oxidase that, respectively, generates reduced glutathione and reactive oxygen species) reactions involved in various cellular actions, yet its physiological function is seldom investigated.	Pentosephosphates	76-93	glutathione reductase	Mus musculus	231-252
21829610-0	2011	Multiple independent fusions of glucose-6-phosphate dehydrogenase with enzymes in the pentose phosphate pathway.	Pentosephosphates	86-103	glucose-6-phosphate dehydrogenase	Homo sapiens	32-65
21157431-0	2011	ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair.	Pentosephosphates	18-35	ATM serine/threonine kinase	Homo sapiens	0-3
21157431-5	2011	Here, we show that ATM promotes an anti-oxidant response by regulating the pentose phosphate pathway (PPP).	Pentosephosphates	75-92	ATM serine/threonine kinase	Homo sapiens	19-22
20947823-7	2011	Circulating haptoglobin and glutathione/total glutathione were significantly higher in the sm22alpha-GLUT1 mice postinjury compared with controls (n=4, P<0.05), suggesting increased flux through the pentose phosphate pathway.	Pentosephosphates	202-219	transgelin	Mus musculus	91-100
20947823-7	2011	Circulating haptoglobin and glutathione/total glutathione were significantly higher in the sm22alpha-GLUT1 mice postinjury compared with controls (n=4, P<0.05), suggesting increased flux through the pentose phosphate pathway.	Pentosephosphates	202-219	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	101-106
20884117-1	2011	Transketolase-like protein 1 (TKTL1) is a member of the family of transketolase enzymes of which the founder member transketolase (TKT) is known to play a central role in the non-oxidative part of the pentose phosphate pathway.	Pentosephosphates	201-218	transketolase like 1	Homo sapiens	0-28
20884117-1	2011	Transketolase-like protein 1 (TKTL1) is a member of the family of transketolase enzymes of which the founder member transketolase (TKT) is known to play a central role in the non-oxidative part of the pentose phosphate pathway.	Pentosephosphates	201-218	transketolase like 1	Homo sapiens	30-35
20884117-1	2011	Transketolase-like protein 1 (TKTL1) is a member of the family of transketolase enzymes of which the founder member transketolase (TKT) is known to play a central role in the non-oxidative part of the pentose phosphate pathway.	Pentosephosphates	201-218	transketolase	Homo sapiens	66-79
20884117-1	2011	Transketolase-like protein 1 (TKTL1) is a member of the family of transketolase enzymes of which the founder member transketolase (TKT) is known to play a central role in the non-oxidative part of the pentose phosphate pathway.	Pentosephosphates	201-218	transketolase	Homo sapiens	116-129
20884117-1	2011	Transketolase-like protein 1 (TKTL1) is a member of the family of transketolase enzymes of which the founder member transketolase (TKT) is known to play a central role in the non-oxidative part of the pentose phosphate pathway.	Pentosephosphates	201-218	transketolase	Homo sapiens	30-33
22091394-1	2011	In trypanosomatids, glucose-6-phosphate dehydrogenase (G6PDH), the first enzyme of the pentosephosphate pathway, is essential for the defense of the parasite against oxidative stress.	Pentosephosphates	87-103	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	55-60
21829610-1	2011	Fusions of the first two enzymes in the pentose phosphate pathway, glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconolactonase (6PGL), have been previously described in two distant clades, chordates and species of the malarial parasite Plasmodium.	Pentosephosphates	40-57	glucose-6-phosphate dehydrogenase	Homo sapiens	67-100
21829610-1	2011	Fusions of the first two enzymes in the pentose phosphate pathway, glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconolactonase (6PGL), have been previously described in two distant clades, chordates and species of the malarial parasite Plasmodium.	Pentosephosphates	40-57	glucose-6-phosphate dehydrogenase	Homo sapiens	102-106
21829610-1	2011	Fusions of the first two enzymes in the pentose phosphate pathway, glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconolactonase (6PGL), have been previously described in two distant clades, chordates and species of the malarial parasite Plasmodium.	Pentosephosphates	40-57	6-phosphogluconolactonase	Homo sapiens	112-137
21829610-1	2011	Fusions of the first two enzymes in the pentose phosphate pathway, glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconolactonase (6PGL), have been previously described in two distant clades, chordates and species of the malarial parasite Plasmodium.	Pentosephosphates	40-57	6-phosphogluconolactonase	Homo sapiens	139-143
20625842-8	2010	In addition, Proteasome (P < .001) and Pentose Phosphate Pathway (P = .01) were identified as specific pathways in each type of HCC recurrence, respectively.	Pentosephosphates	42-59	HCC	Homo sapiens	131-134
21145489-7	2010	Paradoxically, Noxa stimulates glucose consumption and may enhance glucose turnover via the pentose phosphate pathway rather than through glycolysis.	Pentosephosphates	92-109	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	15-19
20738406-0	2010	The Saccharomyces cerevisiae zinc factor protein Stb5p is required as a basal regulator of the pentose phosphate pathway.	Pentosephosphates	95-112	Stb5p	Saccharomyces cerevisiae S288C	49-54
21117170-1	2010	Transketolase (TK, EC 2.2.1.1), the key enzyme of the non-oxidative branch of pentose phosphate pathway of hydrocarbon transformation, plays an important role in a system of substrate rearrangement between pentose shunt and glycolysis, acting as a reversible link between the two metabolic pathways.	Pentosephosphates	78-95	transketolase	Homo sapiens	0-13
21117170-1	2010	Transketolase (TK, EC 2.2.1.1), the key enzyme of the non-oxidative branch of pentose phosphate pathway of hydrocarbon transformation, plays an important role in a system of substrate rearrangement between pentose shunt and glycolysis, acting as a reversible link between the two metabolic pathways.	Pentosephosphates	78-95	transketolase	Homo sapiens	15-17
21155022-2	2010	The G6PD enzyme catalyzes the first step in the pentose phosphate pathway to protect cells against oxidative stress.	Pentosephosphates	48-65	glucose-6-phosphate dehydrogenase	Homo sapiens	4-8
20738406-1	2010	In Saccharomyces cerevisiae, the oxidative stress-activated zinc cluster protein Stb5p activates genes involved in NADPH production and most genes of the pentose phosphate (PP) pathway.	Pentosephosphates	154-171	Stb5p	Saccharomyces cerevisiae S288C	81-86
20816840-5	2010	Elevated intracellular concentrations of pentose-phosphate-pathway intermediates and upregulation of TKL2 and YGR043c (encoding transketolase and transaldolase isoenzymes) suggested an involvement of these genes in flux-controlling reactions in arabinose fermentation.	Pentosephosphates	41-58	transketolase TKL2	Saccharomyces cerevisiae S288C	101-105
20542491-10	2010	In addition, BFT stimulated the activity of pentose phosphate pathway enzymes, leading to reduction of oxidative stress, phosphorylation/activation of VEGF receptor-2 and Akt and increased Pim-1, pBad and Bcl-2 levels.	Pentosephosphates	44-61	kinase insert domain protein receptor	Mus musculus	151-166
20667822-1	2010	The crystal structure of human transketolase (TKT), a thiamine diphosphate (ThDP) and Ca(2+)-dependent enzyme that catalyzes the interketol transfer between ketoses and aldoses as part of the pentose phosphate pathway, has been determined to 1.75 A resolution.	Pentosephosphates	192-209	transketolase	Homo sapiens	31-44
20667822-1	2010	The crystal structure of human transketolase (TKT), a thiamine diphosphate (ThDP) and Ca(2+)-dependent enzyme that catalyzes the interketol transfer between ketoses and aldoses as part of the pentose phosphate pathway, has been determined to 1.75 A resolution.	Pentosephosphates	192-209	transketolase	Homo sapiens	46-49
20506299-5	2010	Conversely, the activity of glucose 6-phosphate dehydrogenase (G6PD), the rate limiting enzyme of the pentose phosphate cycle (PPC) which provides substrates for DNA synthesis, was enhanced in the liver of PTP1B(-/-) animals.	Pentosephosphates	102-119	glucose-6-phosphate dehydrogenase 2	Mus musculus	28-61
20506299-5	2010	Conversely, the activity of glucose 6-phosphate dehydrogenase (G6PD), the rate limiting enzyme of the pentose phosphate cycle (PPC) which provides substrates for DNA synthesis, was enhanced in the liver of PTP1B(-/-) animals.	Pentosephosphates	102-119	glucose-6-phosphate dehydrogenase 2	Mus musculus	63-67
20506299-5	2010	Conversely, the activity of glucose 6-phosphate dehydrogenase (G6PD), the rate limiting enzyme of the pentose phosphate cycle (PPC) which provides substrates for DNA synthesis, was enhanced in the liver of PTP1B(-/-) animals.	Pentosephosphates	102-119	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	206-211
20716531-0	2010	Peroxisome proliferator-activated receptor {gamma} coactivator 1{alpha} (PGC-1{alpha}) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway.	Pentosephosphates	178-195	PPARG coactivator 1 alpha	Homo sapiens	0-70
20716531-0	2010	Peroxisome proliferator-activated receptor {gamma} coactivator 1{alpha} (PGC-1{alpha}) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway.	Pentosephosphates	178-195	PPARG coactivator 1 alpha	Homo sapiens	73-85
20542491-10	2010	In addition, BFT stimulated the activity of pentose phosphate pathway enzymes, leading to reduction of oxidative stress, phosphorylation/activation of VEGF receptor-2 and Akt and increased Pim-1, pBad and Bcl-2 levels.	Pentosephosphates	44-61	thymoma viral proto-oncogene 1	Mus musculus	171-174
20542491-10	2010	In addition, BFT stimulated the activity of pentose phosphate pathway enzymes, leading to reduction of oxidative stress, phosphorylation/activation of VEGF receptor-2 and Akt and increased Pim-1, pBad and Bcl-2 levels.	Pentosephosphates	44-61	B cell leukemia/lymphoma 2	Mus musculus	205-210
20499043-1	2010	Ribose 5-phosphate isomerase (RPI) deficiency is an enzymopathy of the pentose phosphate pathway.	Pentosephosphates	71-88	ribose 5-phosphate isomerase A	Homo sapiens	0-28
20659277-7	2010	We propose that GPT1 is necessary for early embryo development because it catalyses import into plastids of glucose-6-phosphate as the substrate for NADPH generation via the oxidative pentose phosphate pathway.	Pentosephosphates	184-201	glucose 6-phosphate/phosphate translocator 1	Arabidopsis thaliana	16-20
20405262-8	2010	Relative levels of glucose-6-phosphate dehydrogenase (G6PD) vs. phosphofructokinase 2 (PFK2) determine the rate of pentose phosphate pathway (PPP) responsible to synthesize NADPH.	Pentosephosphates	115-132	glucose-6-phosphate dehydrogenase	Rattus norvegicus	19-52
20405262-8	2010	Relative levels of glucose-6-phosphate dehydrogenase (G6PD) vs. phosphofructokinase 2 (PFK2) determine the rate of pentose phosphate pathway (PPP) responsible to synthesize NADPH.	Pentosephosphates	115-132	glucose-6-phosphate dehydrogenase	Rattus norvegicus	54-58
20499043-1	2010	Ribose 5-phosphate isomerase (RPI) deficiency is an enzymopathy of the pentose phosphate pathway.	Pentosephosphates	71-88	ribose 5-phosphate isomerase A	Homo sapiens	30-33
20712627-3	2010	The proposed function of the GPT in plastids of non-green tissues is the provision of Glc6P for starch biosynthesis and/or the oxidative pentose phosphate pathway.	Pentosephosphates	137-154	UDP-glcnac-adolichol phosphate glcnac-1-p-transferase	Arabidopsis thaliana	29-32
20501672-4	2010	A total of 185 genes were highly expressed in the insulin-producing cell lines, and computational analysis predicted the pentose phosphate pathway (PPP), clathrin-mediated endocytosis, and the peroxisome proliferator-activated receptor (PPAR) signaling pathway as important pathways in these cell lines.	Pentosephosphates	121-138	insulin	Homo sapiens	50-57
20450981-6	2010	The mRNA expression of transketolase (Tkt) for pentose phosphate pathway (PPP) enzyme was also evaluated in the liver and kidney.	Pentosephosphates	47-64	transketolase	Rattus norvegicus	23-36
20450981-6	2010	The mRNA expression of transketolase (Tkt) for pentose phosphate pathway (PPP) enzyme was also evaluated in the liver and kidney.	Pentosephosphates	47-64	transketolase	Rattus norvegicus	38-41
20670887-3	2010	Through a combination of unbiased genomic, metabolomic, and bioinformatic approaches, we demonstrate that mTORC1 activation is sufficient to stimulate specific metabolic pathways, including glycolysis, the oxidative arm of the pentose phosphate pathway, and de novo lipid biosynthesis.	Pentosephosphates	227-244	CREB regulated transcription coactivator 1	Mus musculus	106-112
20188835-4	2010	Transketolase is an enzyme that directs the precursors of advanced glycation end products (AGEs) to pentose phosphate pathway.	Pentosephosphates	100-117	transketolase	Homo sapiens	0-13
20403772-1	2010	Glucose 6-phosphate dehydrogenase (G6PD) plays an important role in a ruminant"s metabolism catalyzing the first committed reaction in the pentose phosphate pathway as it provides necessary compounds of NADPH for the synthesis of fatty acids.	Pentosephosphates	139-156	glucose-6-phosphate 1-dehydrogenase	Ovis aries	35-39
20621833-2	2010	6-Aminonicotinamide (6-AN), an inhibitor of the pentose phosphate pathway (PPP), also inhibited the increase of HIF-1alpha protein under hypoxic conditions, while the reduced protein levels of HIF-1alpha by low glucose were apparently recovered by the addition of MG-132 or NADPH.	Pentosephosphates	48-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	112-122
20350285-3	2010	G6PD is a housekeeping X-linked gene encoding the first enzyme of the pentose phosphate pathway, an NADPH-producing dehydrogenase.	Pentosephosphates	70-87	glucose-6-phosphate dehydrogenase	Homo sapiens	0-4
20350285-3	2010	G6PD is a housekeeping X-linked gene encoding the first enzyme of the pentose phosphate pathway, an NADPH-producing dehydrogenase.	Pentosephosphates	70-87	2,4-dienoyl-CoA reductase 1	Homo sapiens	100-105
20403772-1	2010	Glucose 6-phosphate dehydrogenase (G6PD) plays an important role in a ruminant"s metabolism catalyzing the first committed reaction in the pentose phosphate pathway as it provides necessary compounds of NADPH for the synthesis of fatty acids.	Pentosephosphates	139-156	glucose-6-phosphate 1-dehydrogenase	Ovis aries	0-33
20484601-1	2010	PURPOSE: Glucose-6-phosphate dehydrogenase (G6PD) is an important site of metabolic control in the pentose phosphate pathway (PPP), providing reducing power (NADPH) and pentose phosphates.	Pentosephosphates	99-116	glucose-6-phosphate dehydrogenase	Homo sapiens	9-42
20484601-1	2010	PURPOSE: Glucose-6-phosphate dehydrogenase (G6PD) is an important site of metabolic control in the pentose phosphate pathway (PPP), providing reducing power (NADPH) and pentose phosphates.	Pentosephosphates	99-116	glucose-6-phosphate dehydrogenase	Homo sapiens	44-48
20484601-1	2010	PURPOSE: Glucose-6-phosphate dehydrogenase (G6PD) is an important site of metabolic control in the pentose phosphate pathway (PPP), providing reducing power (NADPH) and pentose phosphates.	Pentosephosphates	169-187	glucose-6-phosphate dehydrogenase	Homo sapiens	9-42
20484601-1	2010	PURPOSE: Glucose-6-phosphate dehydrogenase (G6PD) is an important site of metabolic control in the pentose phosphate pathway (PPP), providing reducing power (NADPH) and pentose phosphates.	Pentosephosphates	169-187	glucose-6-phosphate dehydrogenase	Homo sapiens	44-48
20421486-3	2010	Here we report that the major function of glucose metabolism for Kras-induced anchorage-independent growth, a hallmark of transformed cells, is to support the pentose phosphate pathway.	Pentosephosphates	159-176	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	65-69
20200485-2	2010	Recent research has demonstrated that the pentose phosphate pathway (PPP) is augmented in some tumors, especially the non-oxidative part of the PPP which is controlled by transketolase (TKT) enzyme reactions.	Pentosephosphates	42-59	transketolase	Homo sapiens	171-184
20228846-6	2010	HIF-1alpha induction resulted in an enhanced rate of glycolysis but with reduced glucose flux through both the tricarboxylic acid cycle and the oxidative arm of the pentose phosphate pathway (PPP).	Pentosephosphates	165-182	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
20349988-9	2010	H(2)O(2) addition causes down-regulation of enzymes from the glycolytic pathway and Krebs cycle in wild-type K. lactis, whereas glr1-deletion prevents this effect and actually causes up-regulation of the glycolytic, Krebs cycle, and oxidative pentose phosphate pathways.	Pentosephosphates	243-260	glutathione-disulfide reductase GLR1	Saccharomyces cerevisiae S288C	128-132
20200485-2	2010	Recent research has demonstrated that the pentose phosphate pathway (PPP) is augmented in some tumors, especially the non-oxidative part of the PPP which is controlled by transketolase (TKT) enzyme reactions.	Pentosephosphates	42-59	transketolase	Homo sapiens	186-189
20203192-4	2010	Following Abeta(25-35) exposure, we observed an increase in glucose uptake and its various metabolic fates, i.e., glycolysis (coupled to lactate release), tricarboxylic acid cycle, pentose phosphate pathway, and incorporation into glycogen.	Pentosephosphates	181-198	amyloid beta precursor protein	Homo sapiens	10-15
20045004-6	2010	Concomitantly, transcript levels of fetal pyruvate kinase isoform M2, aldolase 3, and transketolase, which shunt the glycolytic with pentose phosphate pathways, were reduced.	Pentosephosphates	133-150	aldolase, fructose-bisphosphate C	Homo sapiens	70-80
20042708-9	2010	Boosting the antioxidative pentose phosphate pathway by benfotiamine supplementation prevented microangiopathy, hypoperfusion, and lineage(-) c-Kit(+) Sca-1(+) cell depletion.	Pentosephosphates	27-44	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	142-147
19822207-3	2010	Conflicting data exist regarding the effect of pO(2) on NADPH production via the oxidative pentose phosphate cycle (OPPC).	Pentosephosphates	91-108	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	56-61
19805580-1	2010	Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway and the principal source of NADPH, a major cellular reductant, and is central to cell survival.	Pentosephosphates	76-93	glucose-6-phosphate dehydrogenase 2	Mus musculus	0-33
19805580-1	2010	Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway and the principal source of NADPH, a major cellular reductant, and is central to cell survival.	Pentosephosphates	76-93	glucose-6-phosphate dehydrogenase 2	Mus musculus	35-39
20107192-6	2010	In hearts of untreated diabetic mice, the expression and activity of Akt/Pim-1 signaling declined along with O-N-acetylglucosamine modification of Akt, inhibition of pentose phosphate pathway, activation of oxidative stress, and accumulation of glycation end products.	Pentosephosphates	166-183	thymoma viral proto-oncogene 1	Mus musculus	69-72
20107192-6	2010	In hearts of untreated diabetic mice, the expression and activity of Akt/Pim-1 signaling declined along with O-N-acetylglucosamine modification of Akt, inhibition of pentose phosphate pathway, activation of oxidative stress, and accumulation of glycation end products.	Pentosephosphates	166-183	proviral integration site 1	Mus musculus	73-78
19815821-11	2009	Furthermore, glycolysis and NADPH generation via the pentose phosphate pathway were activated in Aldh2*2 Tg hearts.	Pentosephosphates	53-70	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	97-102
19804362-2	2010	H6PD converts glucose-6-phosphate and NADP(+) to 6-phosphogluconate and NADPH, thereby catalyzing the first two reactions of the pentose-phosphate pathway.	Pentosephosphates	129-146	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	0-4
19804362-2	2010	H6PD converts glucose-6-phosphate and NADP(+) to 6-phosphogluconate and NADPH, thereby catalyzing the first two reactions of the pentose-phosphate pathway.	Pentosephosphates	129-146	2,4-dienoyl-CoA reductase 1	Homo sapiens	72-77
19711072-1	2010	Phosphoglucose isomerase-deficient (pgi1) strains of Saccharomyces cerevisiae were studied for the production of D-ribose and ribitol from D-glucose via the intermediates of the pentose phosphate pathway.	Pentosephosphates	178-195	glucose-6-phosphate isomerase	Saccharomyces cerevisiae S288C	36-40
21188075-1	2010	Ovine 6-phosphogluconate dehydrogenase (6PGD) is an enzyme of the pentose phosphate pathway, providing the necessary compounds of NADPH for the synthesis of fatty acids.	Pentosephosphates	66-83	phosphogluconate dehydrogenase	Homo sapiens	40-44
19786097-1	2009	The triosephosphate isomerase (TPI) functions at a metabolic cross-road ensuring the rapid equilibration of the triosephosphates produced by aldolase in glycolysis, which is interconnected to lipid metabolism, to glycerol-3-phosphate shuttle and to the pentose phosphate pathway.	Pentosephosphates	253-270	triosephosphate isomerase 1	Mus musculus	4-29
19786097-1	2009	The triosephosphate isomerase (TPI) functions at a metabolic cross-road ensuring the rapid equilibration of the triosephosphates produced by aldolase in glycolysis, which is interconnected to lipid metabolism, to glycerol-3-phosphate shuttle and to the pentose phosphate pathway.	Pentosephosphates	253-270	triosephosphate isomerase 1	Mus musculus	31-34
19769422-3	2009	The G6PD enzyme catalyzes the first step in the pentose phosphate pathway, leading to antioxidants that protect cells against oxidative damage.	Pentosephosphates	48-65	glucose-6-phosphate dehydrogenase	Homo sapiens	4-8
19693011-4	2009	Overexpression of ERBB2 rescues the ATP deficiency by restoring glucose uptake through stabilization of EGFR and phosphatidylinositol-3-OH kinase (PI(3)K) activation, and this rescue is dependent on glucose-stimulated flux through the antioxidant-generating pentose phosphate pathway.	Pentosephosphates	258-275	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-23
19713938-1	2009	The p53-inducible TIGAR protein functions as a fructose-2,6-bisphosphatase, promoting the pentose phosphate pathway and helping to lower intracellular reactive oxygen species (ROS).	Pentosephosphates	90-107	tumor protein p53	Homo sapiens	4-7
19713938-1	2009	The p53-inducible TIGAR protein functions as a fructose-2,6-bisphosphatase, promoting the pentose phosphate pathway and helping to lower intracellular reactive oxygen species (ROS).	Pentosephosphates	90-107	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	18-23
19448666-5	2009	We demonstrate that endogenous c-myc increased (13)C labeling of ribose sugars, purines and amino acids, indicating partitioning of glucose carbons into C1/folate and pentose phosphate pathways, and increased tricarboxylic acid cycle turnover at the expense of anaplerotic flux.	Pentosephosphates	167-184	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	31-36
19517136-7	2009	The enhanced expression of ZWF1 appeared to drive glucose metabolism in favor of pentose phosphate pathway over glycolysis at earlier steps of glucose metabolisms.	Pentosephosphates	81-98	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	27-31
19401148-2	2009	The nearly ubiquitous enzyme transaldolase is a part of the pentose phosphate pathway and transfers a dihydroxyacetone group from donor compounds (fructose 6-phosphate or sedoheptulose 7-phosphate) to aldehyde acceptor compounds.	Pentosephosphates	60-77	transaldolase 1	Homo sapiens	29-42
19415679-9	2009	Glucose deprivation increased intracellular proline levels, and expression of POX activated the pentose phosphate pathway.	Pentosephosphates	96-113	proline dehydrogenase 1	Homo sapiens	78-81
19443197-6	2009	We review evidence from studies of adrenalectomized rats, as well as studies linking 11beta-HSD-1 to the pentose phosphate pathway and other metabolic pathways via the enzyme hexose-6-phosphate dehydrogenase.	Pentosephosphates	105-122	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	85-97
19457984-9	2009	We demonstrate that plastidic (not peroxisomal) localization and 6PGL activity of the PGL3 protein are essential for complementing all pgl3 phenotypes, indicating that the oxidative section of the plastidic pentose phosphate pathway (PPP) is required for plant normal growth and development.	Pentosephosphates	207-224	NagB/RpiA/CoA transferase-like superfamily protein	Arabidopsis thaliana	86-90
19284595-1	2009	BACKGROUND: Human glucose 6-phosphate dehydrogenase (G6PD), active in both dimer and tetramer forms, is the key entry enzyme in the pentose phosphate pathway (PPP), providing NADPH for biosynthesis and various other purposes, including protection against oxidative stress in erythrocytes.	Pentosephosphates	132-149	glucose-6-phosphate dehydrogenase	Homo sapiens	18-51
19253370-4	2009	Here, we reveal that glucose-6-phosphate dehydrogenase (G6PDH) and transketolase (TKT), the 2 key enzymes of oxidative and nonoxidative branches of the pentose phosphate pathway (PPP), respectively, which is necessary for nucleotide synthesis, are enhanced during cell cycle progression of the human colon cancer cell line HT29.	Pentosephosphates	152-169	glucose-6-phosphate dehydrogenase	Homo sapiens	21-54
19253370-4	2009	Here, we reveal that glucose-6-phosphate dehydrogenase (G6PDH) and transketolase (TKT), the 2 key enzymes of oxidative and nonoxidative branches of the pentose phosphate pathway (PPP), respectively, which is necessary for nucleotide synthesis, are enhanced during cell cycle progression of the human colon cancer cell line HT29.	Pentosephosphates	152-169	glucose-6-phosphate dehydrogenase	Homo sapiens	56-61
19253370-4	2009	Here, we reveal that glucose-6-phosphate dehydrogenase (G6PDH) and transketolase (TKT), the 2 key enzymes of oxidative and nonoxidative branches of the pentose phosphate pathway (PPP), respectively, which is necessary for nucleotide synthesis, are enhanced during cell cycle progression of the human colon cancer cell line HT29.	Pentosephosphates	152-169	transketolase	Homo sapiens	67-80
19253370-4	2009	Here, we reveal that glucose-6-phosphate dehydrogenase (G6PDH) and transketolase (TKT), the 2 key enzymes of oxidative and nonoxidative branches of the pentose phosphate pathway (PPP), respectively, which is necessary for nucleotide synthesis, are enhanced during cell cycle progression of the human colon cancer cell line HT29.	Pentosephosphates	152-169	transketolase	Homo sapiens	82-85
19383711-5	2009	Whilst Gis1p and Rim15p have distinct functions in gene repression, the growth defects of gis1 or rim15 deletants can be accounted for by the overlapping functions of their protein products in promoting the expression of genes involved in glutamate biosynthesis, the glyoxylate cycle, the pentose phosphate pathway and the stress response.	Pentosephosphates	289-306	histone demethylase GIS1	Saccharomyces cerevisiae S288C	90-94
19383711-5	2009	Whilst Gis1p and Rim15p have distinct functions in gene repression, the growth defects of gis1 or rim15 deletants can be accounted for by the overlapping functions of their protein products in promoting the expression of genes involved in glutamate biosynthesis, the glyoxylate cycle, the pentose phosphate pathway and the stress response.	Pentosephosphates	289-306	protein kinase RIM15	Saccharomyces cerevisiae S288C	98-103
19039788-2	2009	In addition to direct effects of tkt deficiency, the mutation in non-oxidative part of pentose phosphate pathway (PPP) is known to display several unexpected physiological characteristics such as decreased ability to utilize D-glucose, altered carbon catabolite repression, lack of motility, etc.	Pentosephosphates	87-104	AKO65_RS14630	Bacillus pumilus	33-36
18490188-3	2009	Transketolase is an important enzyme in the non-oxidative branch of the pentose phosphate pathway (PPP), a pathway responsible for generating reducing equivalents, which is essential for energy transduction and for generating ribose for nucleic acid synthesis.	Pentosephosphates	72-89	transketolase	Homo sapiens	0-13
19436114-2	2009	Recent case reports suggest a link between the pentose phosphate pathway (PPP) enzyme transaldolase (TAL; encoded by TALDO1) and liver failure in children.	Pentosephosphates	47-64	transaldolase 1	Mus musculus	86-99
19436114-2	2009	Recent case reports suggest a link between the pentose phosphate pathway (PPP) enzyme transaldolase (TAL; encoded by TALDO1) and liver failure in children.	Pentosephosphates	47-64	transaldolase 1	Homo sapiens	101-104
19436114-2	2009	Recent case reports suggest a link between the pentose phosphate pathway (PPP) enzyme transaldolase (TAL; encoded by TALDO1) and liver failure in children.	Pentosephosphates	47-64	transaldolase 1	Homo sapiens	117-123
19299175-1	2009	Transaldolase (TALDO) deficiency is a recently described inborn error of metabolism of the pentose phosphate pathway that so far has been diagnosed in only eight patients.	Pentosephosphates	91-108	transaldolase 1	Homo sapiens	0-13
19299175-1	2009	Transaldolase (TALDO) deficiency is a recently described inborn error of metabolism of the pentose phosphate pathway that so far has been diagnosed in only eight patients.	Pentosephosphates	91-108	transaldolase 1	Homo sapiens	15-20
19290028-1	2009	Transketolase (TK), a thiamine diphosphate (ThDP)-dependent enzyme, catalyzes several key reactions of non-oxidative branch of pentose phosphate pathway.	Pentosephosphates	127-144	transketolase	Homo sapiens	0-13
19290028-1	2009	Transketolase (TK), a thiamine diphosphate (ThDP)-dependent enzyme, catalyzes several key reactions of non-oxidative branch of pentose phosphate pathway.	Pentosephosphates	127-144	transketolase	Homo sapiens	15-17
19284595-1	2009	BACKGROUND: Human glucose 6-phosphate dehydrogenase (G6PD), active in both dimer and tetramer forms, is the key entry enzyme in the pentose phosphate pathway (PPP), providing NADPH for biosynthesis and various other purposes, including protection against oxidative stress in erythrocytes.	Pentosephosphates	132-149	glucose-6-phosphate dehydrogenase	Homo sapiens	53-57
19183269-8	2009	Further studies showed that HIF-1 regulated not only glucose transporter-1 expression, but also the key enzymes of the pentose phosphate pathway such as glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase.	Pentosephosphates	119-136	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
19183269-8	2009	Further studies showed that HIF-1 regulated not only glucose transporter-1 expression, but also the key enzymes of the pentose phosphate pathway such as glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase.	Pentosephosphates	119-136	glucose-6-phosphate dehydrogenase	Homo sapiens	153-186
19052774-4	2009	Using GFP fusion constructs and enzymatic activity assays, we demonstrate that C. plantagineum has novel forms of transketolase which localize not to the chloroplast, but mainly to the cytoplasm and which are distinct in the enzymatic properties from the transketolase enzymes active in the Calvin cycle or oxidative pentose phosphate pathway.	Pentosephosphates	317-334	transketolase	Homo sapiens	114-127
19111488-1	2009	Transketolase, the most critical enzyme of the non-oxidative branch of the pentose phosphate pathway, has been reported as a new target protein for cancer research.	Pentosephosphates	75-92	transketolase	Homo sapiens	0-13
19129474-1	2009	Genome-wide screening for sensitivity to chronic endoplasmic reticulum (ER) stress induced by dithiothreitol and tunicamycin (TM) identified mutants deleted for Cu, Zn superoxide dismutase (SOD) function (SOD1, CCS1) or affected in NADPH generation via the pentose phosphate pathway (TKL1, RPE1).	Pentosephosphates	257-274	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	190-193
19068483-6	2009	PI3K/Akt regulated early steps of de novo synthesis by modulating phosphoribosylpyrophosphate production by the non-oxidative pentose phosphate pathway and late steps by modulating activity of the bifunctional enzyme aminoimidazole-carboxamide ribonucleotide transformylase IMP cyclohydrolase, an enzyme not previously known to be regulated.	Pentosephosphates	126-143	thymoma viral proto-oncogene 1	Mus musculus	5-8
19201187-4	2009	In order to achieve elevated rates of nucleotide biosynthesis, neoplastic cells must divert carbon from PI3K/Akt-induced glycolytic flux into the nonoxidative branch of the pentose phosphate pathway to generate ribose-5-phosphate.	Pentosephosphates	173-190	AKT serine/threonine kinase 1	Homo sapiens	109-112
19083487-2	2008	This 5-carbon sugar, synthesized from glucose via the pentose phosphate pathway, has a rate-limiting step at glucose-6-phosphate dehydrogenase.	Pentosephosphates	54-71	glucose-6-phosphate dehydrogenase	Homo sapiens	109-142
18393672-3	2009	Here, we demonstrate the detection of the pentose phosphate pathway enzyme, transketolase (TK), in BM-derived IPCs cultured under high-glucose conditions.	Pentosephosphates	42-59	transketolase	Rattus norvegicus	76-89
18393672-3	2009	Here, we demonstrate the detection of the pentose phosphate pathway enzyme, transketolase (TK), in BM-derived IPCs cultured under high-glucose conditions.	Pentosephosphates	42-59	transketolase	Rattus norvegicus	91-93
18393672-8	2009	However, in cells where the pentose phosphate pathway was blocked by oxythiamine treatment, there was a clear downregulation of Glut-2, glucokinase, insulin, and GAPDH.	Pentosephosphates	28-45	solute carrier family 2 member 2	Rattus norvegicus	128-134
18393672-8	2009	However, in cells where the pentose phosphate pathway was blocked by oxythiamine treatment, there was a clear downregulation of Glut-2, glucokinase, insulin, and GAPDH.	Pentosephosphates	28-45	glucokinase	Rattus norvegicus	136-147
18393672-8	2009	However, in cells where the pentose phosphate pathway was blocked by oxythiamine treatment, there was a clear downregulation of Glut-2, glucokinase, insulin, and GAPDH.	Pentosephosphates	28-45	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	162-167
19526128-1	2009	Activity of histochemically determined glucose-6-phosphate dehydrogenase, a key enzyme of the pentose phosphate pathway, was qualitatively determined in layer III and V neurons of the sensorimotor cortex and neurons of the caudate nucleus, nucleus accumbens, and hippocampus (CA3) in mature male Wistar rats with high and low locomotor activity in an open field.	Pentosephosphates	94-111	glucose-6-phosphate dehydrogenase	Rattus norvegicus	39-72
19526128-2	2009	A negative correlation was revealed between locomotion of Wistar rats in the open field and activity of glucose-6-phosphate dehydrogenase in the sensorimotor cortex, especially in efferent layer V neurons and neurons of the caudate nucleus and nucleus accumbens, which attested to different capacity of the brain in Wistar rats with high and low open-field locomotion to regeneration of phosphopyridine nucleotides (NADP(+)) and production of pentoses via the pentose phosphate shunt.	Pentosephosphates	460-477	glucose-6-phosphate dehydrogenase	Rattus norvegicus	104-137
18987987-1	2008	The recent discovery of two defects (ribose-5-phosphate isomerase deficiency and transaldolase deficiency) in the reversible part of the pentose phosphate pathway (PPP) has stimulated interest in this pathway.	Pentosephosphates	137-154	ribose 5-phosphate isomerase A	Homo sapiens	37-65
19029908-5	2008	In healthy neurons and cancer cells, however, cytochrome c is reduced and held inactive by intracellular glutathione (GSH), generated as a result of glucose metabolism by the pentose phosphate pathway.	Pentosephosphates	175-192	cytochrome c, somatic	Homo sapiens	46-58
18806116-9	2008	The latter, catalyzed by mitochondrial POX and cytosolic pyrroline-5-carboxylate reductase, shuttles reducing potential from the pentose phosphate pathway into mitochondria to generate ATP and oxidizing potential to activate the cytosolic pentose phosphate pathway.	Pentosephosphates	129-146	proline dehydrogenase 1	Homo sapiens	39-42
19061187-3	2008	We focused on six of these genes required for acetaldehyde tolerance, ZWF1, GND1, RPE1, TKL1 and TAL1, which encode enzymes in the pentose phosphate pathway (PPP), and OAR1, which encodes for NADPH-dependent 3-oxoacyl-(acyl-carrier-protein) reductase.	Pentosephosphates	131-148	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	70-74
19061187-3	2008	We focused on six of these genes required for acetaldehyde tolerance, ZWF1, GND1, RPE1, TKL1 and TAL1, which encode enzymes in the pentose phosphate pathway (PPP), and OAR1, which encodes for NADPH-dependent 3-oxoacyl-(acyl-carrier-protein) reductase.	Pentosephosphates	131-148	phosphogluconate dehydrogenase (decarboxylating) GND1	Saccharomyces cerevisiae S288C	76-80
19061187-3	2008	We focused on six of these genes required for acetaldehyde tolerance, ZWF1, GND1, RPE1, TKL1 and TAL1, which encode enzymes in the pentose phosphate pathway (PPP), and OAR1, which encodes for NADPH-dependent 3-oxoacyl-(acyl-carrier-protein) reductase.	Pentosephosphates	131-148	ribulose-phosphate 3-epimerase RPE1	Saccharomyces cerevisiae S288C	82-86
19061187-3	2008	We focused on six of these genes required for acetaldehyde tolerance, ZWF1, GND1, RPE1, TKL1 and TAL1, which encode enzymes in the pentose phosphate pathway (PPP), and OAR1, which encodes for NADPH-dependent 3-oxoacyl-(acyl-carrier-protein) reductase.	Pentosephosphates	131-148	transketolase TKL1	Saccharomyces cerevisiae S288C	88-92
19061187-3	2008	We focused on six of these genes required for acetaldehyde tolerance, ZWF1, GND1, RPE1, TKL1 and TAL1, which encode enzymes in the pentose phosphate pathway (PPP), and OAR1, which encodes for NADPH-dependent 3-oxoacyl-(acyl-carrier-protein) reductase.	Pentosephosphates	131-148	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1	Saccharomyces cerevisiae S288C	97-101
18498245-1	2008	TAL (transaldolase) was originally described in the yeast as an enzyme of the PPP (pentose phosphate pathway).	Pentosephosphates	83-100	transaldolase 1	Homo sapiens	0-3
18498245-1	2008	TAL (transaldolase) was originally described in the yeast as an enzyme of the PPP (pentose phosphate pathway).	Pentosephosphates	83-100	transaldolase 1	Homo sapiens	5-18
18806116-9	2008	The latter, catalyzed by mitochondrial POX and cytosolic pyrroline-5-carboxylate reductase, shuttles reducing potential from the pentose phosphate pathway into mitochondria to generate ATP and oxidizing potential to activate the cytosolic pentose phosphate pathway.	Pentosephosphates	239-256	proline dehydrogenase 1	Homo sapiens	39-42
18562474-6	2008	The pentose phosphate pathway was stimulated in frataxin-deficient cells, glucose-6-phosphate dehydrogenase activity was three times higher than in wild-type cells and this was coupled to a defect in the NADPH/NADP(+) pool.	Pentosephosphates	4-21	frataxin	Homo sapiens	48-56
18606812-6	2008	The pfkA2 deletion strain had an increased carbon flux through the pentose phosphate pathway, as measured by (13)C metabolic flux analysis, establishing the ATP-dependent PfkA2 as a key player in determining the carbon flux distribution.	Pentosephosphates	67-84	SCO5426	Streptomyces coelicolor A3(2)	4-9
18606812-6	2008	The pfkA2 deletion strain had an increased carbon flux through the pentose phosphate pathway, as measured by (13)C metabolic flux analysis, establishing the ATP-dependent PfkA2 as a key player in determining the carbon flux distribution.	Pentosephosphates	67-84	SCO5426	Streptomyces coelicolor A3(2)	171-176
18562474-6	2008	The pentose phosphate pathway was stimulated in frataxin-deficient cells, glucose-6-phosphate dehydrogenase activity was three times higher than in wild-type cells and this was coupled to a defect in the NADPH/NADP(+) pool.	Pentosephosphates	4-21	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	74-107
18422600-1	2008	(Pre)neoplastic lesions in livers of rats induced by diethylnitrosamine are characterized by elevated activity of the first irreversible enzyme of the oxidative branch of the pentose phosphate pathway (PPP), glucose-6-phosphate dehydrogenase (G6PD), for production of NADPH.	Pentosephosphates	175-192	glucose-6-phosphate dehydrogenase	Rattus norvegicus	243-247
19253743-2	2008	Minimal inhibitory effect (MIA) and increase of enzyme activity of pentosephosphate ways such as: glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, transketolase testify to an intensification pentose-phosphate ways and decrease in activity of found the second groups staphylococcus isolated at vaginosis in comparison with of the in third group isolated at vaginosis and additional infection pathology as well as in comparison with the first control group staphylococcus isolated at normal state of UGT.	Pentosephosphates	67-83	glucose-6-phosphate dehydrogenase	Homo sapiens	98-131
18455501-4	2008	In addition, nitric oxide activates glucose-6-phosphate dehydrogenase, the first and rate-limiting step of the pentose-phosphate pathway.	Pentosephosphates	111-128	glucose-6-phosphate dehydrogenase	Homo sapiens	36-69
18383346-5	2008	Thus, IL-1beta+TNFalpha treated astrocytes show a marked decrease in glycogen levels, a slight but not significant decrease in lactate release as well as a massive increase in both the pentose phosphate pathway and TCA cycle activities.	Pentosephosphates	185-202	interleukin 1 beta	Mus musculus	6-14
18383346-5	2008	Thus, IL-1beta+TNFalpha treated astrocytes show a marked decrease in glycogen levels, a slight but not significant decrease in lactate release as well as a massive increase in both the pentose phosphate pathway and TCA cycle activities.	Pentosephosphates	185-202	tumor necrosis factor	Mus musculus	15-23
19253743-2	2008	Minimal inhibitory effect (MIA) and increase of enzyme activity of pentosephosphate ways such as: glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, transketolase testify to an intensification pentose-phosphate ways and decrease in activity of found the second groups staphylococcus isolated at vaginosis in comparison with of the in third group isolated at vaginosis and additional infection pathology as well as in comparison with the first control group staphylococcus isolated at normal state of UGT.	Pentosephosphates	67-83	transketolase	Homo sapiens	167-180
19253743-2	2008	Minimal inhibitory effect (MIA) and increase of enzyme activity of pentosephosphate ways such as: glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, transketolase testify to an intensification pentose-phosphate ways and decrease in activity of found the second groups staphylococcus isolated at vaginosis in comparison with of the in third group isolated at vaginosis and additional infection pathology as well as in comparison with the first control group staphylococcus isolated at normal state of UGT.	Pentosephosphates	67-83	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	518-521
19253743-2	2008	Minimal inhibitory effect (MIA) and increase of enzyme activity of pentosephosphate ways such as: glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, transketolase testify to an intensification pentose-phosphate ways and decrease in activity of found the second groups staphylococcus isolated at vaginosis in comparison with of the in third group isolated at vaginosis and additional infection pathology as well as in comparison with the first control group staphylococcus isolated at normal state of UGT.	Pentosephosphates	211-228	glucose-6-phosphate dehydrogenase	Homo sapiens	98-131
19253743-2	2008	Minimal inhibitory effect (MIA) and increase of enzyme activity of pentosephosphate ways such as: glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, transketolase testify to an intensification pentose-phosphate ways and decrease in activity of found the second groups staphylococcus isolated at vaginosis in comparison with of the in third group isolated at vaginosis and additional infection pathology as well as in comparison with the first control group staphylococcus isolated at normal state of UGT.	Pentosephosphates	211-228	transketolase	Homo sapiens	167-180
19253743-2	2008	Minimal inhibitory effect (MIA) and increase of enzyme activity of pentosephosphate ways such as: glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, transketolase testify to an intensification pentose-phosphate ways and decrease in activity of found the second groups staphylococcus isolated at vaginosis in comparison with of the in third group isolated at vaginosis and additional infection pathology as well as in comparison with the first control group staphylococcus isolated at normal state of UGT.	Pentosephosphates	211-228	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	518-521
18331807-1	2008	Transaldolase (TALDO) deficiency is a rare inborn error of the pentose phosphate pathway.	Pentosephosphates	63-80	transaldolase 1	Homo sapiens	0-13
18331807-1	2008	Transaldolase (TALDO) deficiency is a rare inborn error of the pentose phosphate pathway.	Pentosephosphates	63-80	transaldolase 1	Homo sapiens	15-20
18083562-1	2008	Transketolase, a key enzyme in the pentose phosphate pathway, has been suggested as a target for inhibition in the treatment of cancer.	Pentosephosphates	35-52	transketolase	Homo sapiens	0-13
18036177-0	2008	Glucose utilization of strains lacking PGI1 and expressing a transhydrogenase suggests differences in the pentose phosphate capacity among Saccharomyces cerevisiae strains.	Pentosephosphates	106-123	glucose-6-phosphate isomerase	Saccharomyces cerevisiae S288C	39-43
18036177-1	2008	Saccharomyces cerevisiae strains lacking phosphoglucose isomerase (pgi1) cannot use the pentose phosphate (PP) pathway to oxidize glucose, which has been explained by the lack of mechanism for reoxidation of the NADPH surplus.	Pentosephosphates	88-105	glucose-6-phosphate isomerase	Saccharomyces cerevisiae S288C	67-71
18029214-8	2008	Furthermore, the activity and transcript level of the lipogenic enzyme glucose-6-phosphate dehydrogenase, the rate-limiting enzyme of the pentose phosphate pathway, were also about 2-fold higher than that of the wild-type; these data corroborate the flux analysis results.	Pentosephosphates	138-155	glucose-6-phosphate dehydrogenase	Rattus norvegicus	71-104
19812737-7	2008	TKTL1-activity could be the basis for a rapid fermentation of glucose in aggressive carcinoma cells via the pentose phosphate pathway, which leads to matrix acidification, invasive growth, and ultimately metastasis.	Pentosephosphates	108-125	transketolase like 1	Homo sapiens	0-5
18370412-2	2008	In this study, we report that in murine alveolar MH-S macrophages, a 24 h incubation with quartz particles (80 microg/cm(2)) inhibits the glucose 6-phosphate dehydrogenase (G6PD) (1) activity by 70% and the pentose phosphate pathway by 30%.	Pentosephosphates	207-224	glucose-6-phosphate dehydrogenase 2	Mus musculus	138-171
18370412-2	2008	In this study, we report that in murine alveolar MH-S macrophages, a 24 h incubation with quartz particles (80 microg/cm(2)) inhibits the glucose 6-phosphate dehydrogenase (G6PD) (1) activity by 70% and the pentose phosphate pathway by 30%.	Pentosephosphates	207-224	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Mus musculus	173-181
18222920-1	2008	Hexose-6-phosphate dehydrogenase (H6PD) is the initial component of a pentose phosphate pathway inside the endoplasmic reticulum (ER) that generates NADPH for ER enzymes.	Pentosephosphates	70-87	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Mus musculus	0-32
18222920-1	2008	Hexose-6-phosphate dehydrogenase (H6PD) is the initial component of a pentose phosphate pathway inside the endoplasmic reticulum (ER) that generates NADPH for ER enzymes.	Pentosephosphates	70-87	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Mus musculus	34-38
18003902-5	2007	The picture that emerges suggests that the conserved genes YKU70, MRE11, AIF1, and ZWF1, and the processes of retrotransposition, apoptosis, and the oxidative pentose phosphate pathway that these genes are involved in, may play significant, yet previously unrecognized, roles in the differential effects of hydrogen peroxide and menadione on cell cycle progression.	Pentosephosphates	159-176	ATP-dependent DNA helicase YKU70	Saccharomyces cerevisiae S288C	59-64
17666400-0	2007	Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration: implications for the mechanism of HIF-1alpha stabilization under moderate hypoxia.	Pentosephosphates	62-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	166-176
18338571-2	2008	G6PDH is the first enzyme in the oxidative pentose phosphate pathway (PPP) and the key enzyme for NADPH generation.	Pentosephosphates	43-60	DF17_RS17135	Streptomyces rimosus	0-5
17919760-6	2007	Deletion of malic enzyme gene, MAE1, did not show any significant phenotype when grown on glucose but a drastically increased branching from glucose 6-phosphate into the pentose phosphate pathway when grown on galactose.	Pentosephosphates	170-187	malate dehydrogenase (oxaloacetate-decarboxylating)	Saccharomyces cerevisiae S288C	31-35
18003902-5	2007	The picture that emerges suggests that the conserved genes YKU70, MRE11, AIF1, and ZWF1, and the processes of retrotransposition, apoptosis, and the oxidative pentose phosphate pathway that these genes are involved in, may play significant, yet previously unrecognized, roles in the differential effects of hydrogen peroxide and menadione on cell cycle progression.	Pentosephosphates	159-176	MRX complex nuclease subunit	Saccharomyces cerevisiae S288C	66-71
18003902-5	2007	The picture that emerges suggests that the conserved genes YKU70, MRE11, AIF1, and ZWF1, and the processes of retrotransposition, apoptosis, and the oxidative pentose phosphate pathway that these genes are involved in, may play significant, yet previously unrecognized, roles in the differential effects of hydrogen peroxide and menadione on cell cycle progression.	Pentosephosphates	159-176	Aif1p	Saccharomyces cerevisiae S288C	73-77
18003902-5	2007	The picture that emerges suggests that the conserved genes YKU70, MRE11, AIF1, and ZWF1, and the processes of retrotransposition, apoptosis, and the oxidative pentose phosphate pathway that these genes are involved in, may play significant, yet previously unrecognized, roles in the differential effects of hydrogen peroxide and menadione on cell cycle progression.	Pentosephosphates	159-176	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	83-87
17988018-5	2007	The support of glutathione reductase activity under stress in this group with simultaneous decrease of enzyme activity in the pentose phosphate pathway was realized through the participation of NADP-IDH.	Pentosephosphates	126-143	glutathione-disulfide reductase	Rattus norvegicus	15-36
17711992-5	2007	In addition, the alternations in liver metabolism seen in GLUT4 nulls including increased GLUT2 expression and fatty acid synthesis accompanied by an increase in the oxidative arm of the pentose phosphate pathway were absent in G4-MO mice.	Pentosephosphates	187-204	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	58-63
17553476-6	2007	Glucose-dependent p70S6K phosphorylation was independent of the hexosamine biosynthetic pathway, the AMP kinase pathway, and the pentose phosphate pathway.	Pentosephosphates	129-146	ribosomal protein S6 kinase B1	Rattus norvegicus	18-24
17650590-8	2007	Higher activities of phosphoglucomutase and fructose-1,6-phosphatase in mungbean cytosolic fraction could lead to increased flow of carbon towards pentose phosphate pathway.	Pentosephosphates	147-164	uncharacterized protein LOC106771950	Vigna radiata	21-39
17699161-3	2007	We show here that deletion of one PPARgamma allele not only affected lipid storage but, more surprisingly, also the expression of genes involved in glucose uptake and utilization, the pentose phosphate pathway, fatty acid synthesis, lipolysis, and glycerol export as well as in IR/IGF-1 signaling.	Pentosephosphates	184-201	peroxisome proliferator activated receptor gamma	Mus musculus	34-43
17533217-2	2007	Four enzymes produce NADPH: glucose-6-phosphate dehydrogenase (G6PD), the key regulatory enzyme of the pentose phosphate pathway, phosphogluconate dehydrogenase (PGD), the third enzyme of that pathway, malate dehydrogenase (MDH), and isocitrate dehydrogenase (ICDH).	Pentosephosphates	103-120	glucose-6-phosphate dehydrogenase	Rattus norvegicus	28-61
17533217-2	2007	Four enzymes produce NADPH: glucose-6-phosphate dehydrogenase (G6PD), the key regulatory enzyme of the pentose phosphate pathway, phosphogluconate dehydrogenase (PGD), the third enzyme of that pathway, malate dehydrogenase (MDH), and isocitrate dehydrogenase (ICDH).	Pentosephosphates	103-120	glucose-6-phosphate dehydrogenase	Rattus norvegicus	63-67
17533217-2	2007	Four enzymes produce NADPH: glucose-6-phosphate dehydrogenase (G6PD), the key regulatory enzyme of the pentose phosphate pathway, phosphogluconate dehydrogenase (PGD), the third enzyme of that pathway, malate dehydrogenase (MDH), and isocitrate dehydrogenase (ICDH).	Pentosephosphates	103-120	phosphogluconate dehydrogenase	Rattus norvegicus	130-160
17623517-1	2007	Glucose-6-phosphate dehydrogenase (G6PD), the first and rate-limiting enzyme of the pentose phosphate pathway, is indispensable to maintenance of the cytosolic pool of NADPH and thus the cellular redox balance.	Pentosephosphates	84-101	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
17157446-1	2007	Glucose 6-phosphate dehydrogenase (G6PD) plays an important role in ruminant"s lipogenesis, as it provides necessary compounds of NADPH for the synthesis of fatty acids catalyzing the first committed reaction in the pentose phosphate pathway.	Pentosephosphates	216-233	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
17157446-1	2007	Glucose 6-phosphate dehydrogenase (G6PD) plays an important role in ruminant"s lipogenesis, as it provides necessary compounds of NADPH for the synthesis of fatty acids catalyzing the first committed reaction in the pentose phosphate pathway.	Pentosephosphates	216-233	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
17240046-2	2007	This requires NADPH, generated by hexose-6-phosphate dehydrogenase (H6PD), a component of the pentose phosphate pathway.	Pentosephosphates	94-111	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Mus musculus	34-66
17240046-2	2007	This requires NADPH, generated by hexose-6-phosphate dehydrogenase (H6PD), a component of the pentose phosphate pathway.	Pentosephosphates	94-111	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Mus musculus	68-72
17207784-2	2007	Thiamin (Vitamin B(1)) is an essential coenzyme for transketolase (TK) that is part of the pentose phosphate pathway which helps maintain cellular NADPH levels.	Pentosephosphates	91-108	transketolase	Homo sapiens	52-65
17207784-2	2007	Thiamin (Vitamin B(1)) is an essential coenzyme for transketolase (TK) that is part of the pentose phosphate pathway which helps maintain cellular NADPH levels.	Pentosephosphates	91-108	transketolase	Homo sapiens	67-69
17623517-1	2007	Glucose-6-phosphate dehydrogenase (G6PD), the first and rate-limiting enzyme of the pentose phosphate pathway, is indispensable to maintenance of the cytosolic pool of NADPH and thus the cellular redox balance.	Pentosephosphates	84-101	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
16914749-8	2006	Integrity of the pentose phosphate pathway is required for the activation of Stb5 target genes but is not necessary for the increased DNA binding of Stb5 in the presence of diamide.	Pentosephosphates	17-34	Stb5p	Saccharomyces cerevisiae S288C	77-81
17424909-3	2006	The physiological function of TPI is to adjust the rapid equilibrium between dihydroxyacetone phosphate and glyceraldehyde-3-phosphate produced by aldolase in glycolysis, which is interconnected to the pentose phosphate pathway and to lipid metabolism via triosephosphates.	Pentosephosphates	202-219	triosephosphate isomerase 1	Homo sapiens	30-33
16969476-1	2006	The nonoxidative pentose phosphate pathway allows glucose conversion to ribose for DNA or RNA synthesis and glucose degradation to lactate controlled by transketolase enzyme reactions.	Pentosephosphates	17-34	transketolase	Homo sapiens	153-166
16914749-0	2006	Oxidative stress-activated zinc cluster protein Stb5 has dual activator/repressor functions required for pentose phosphate pathway regulation and NADPH production.	Pentosephosphates	105-122	Stb5p	Saccharomyces cerevisiae S288C	48-52
16914749-4	2006	Interestingly, upon oxidative stress, Stb5 binds and regulates the expression of most genes of the pentose phosphate pathway as well as of genes involved in the production of NADPH, a metabolite required for oxidative stress resistance.	Pentosephosphates	99-116	Stb5p	Saccharomyces cerevisiae S288C	38-42
16828794-2	2006	NADPH is supplied principally by the pentose phosphate pathway, whose rate-limiting enzyme is glucose 6-phosphate dehydrogenase (G6PD).	Pentosephosphates	37-54	glucose-6-phosphate dehydrogenase	Canis lupus familiaris	94-127
16828794-2	2006	NADPH is supplied principally by the pentose phosphate pathway, whose rate-limiting enzyme is glucose 6-phosphate dehydrogenase (G6PD).	Pentosephosphates	37-54	glucose-6-phosphate dehydrogenase	Canis lupus familiaris	129-133
16789437-1	2006	Glucose-6-phosphate dehydrogenase (G-6-PD) is the first enzyme in the pentose phosphate pathway.	Pentosephosphates	70-87	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
16222531-0	2006	Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae.	Pentosephosphates	56-73	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	88-92
16222531-0	2006	Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae.	Pentosephosphates	56-73	phosphogluconate dehydrogenase (decarboxylating) GND1	Saccharomyces cerevisiae S288C	94-98
16222531-0	2006	Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae.	Pentosephosphates	56-73	ribulose-phosphate 3-epimerase RPE1	Saccharomyces cerevisiae S288C	100-104
16222531-0	2006	Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae.	Pentosephosphates	56-73	transketolase TKL1	Saccharomyces cerevisiae S288C	110-114
16222531-5	2006	We focused on four mutants, zwf1, gnd1, rpe1, and tkl1, which represent genes encoding pentose phosphate pathway (PPP) enzymes.	Pentosephosphates	87-104	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	28-32
16222531-5	2006	We focused on four mutants, zwf1, gnd1, rpe1, and tkl1, which represent genes encoding pentose phosphate pathway (PPP) enzymes.	Pentosephosphates	87-104	phosphogluconate dehydrogenase (decarboxylating) GND1	Saccharomyces cerevisiae S288C	34-38
16222531-5	2006	We focused on four mutants, zwf1, gnd1, rpe1, and tkl1, which represent genes encoding pentose phosphate pathway (PPP) enzymes.	Pentosephosphates	87-104	ribulose-phosphate 3-epimerase RPE1	Saccharomyces cerevisiae S288C	40-44
16222531-5	2006	We focused on four mutants, zwf1, gnd1, rpe1, and tkl1, which represent genes encoding pentose phosphate pathway (PPP) enzymes.	Pentosephosphates	87-104	transketolase TKL1	Saccharomyces cerevisiae S288C	50-54
16452468-8	2006	Activation of transketolase may shift excess glycolytic metabolites into the pentose phosphate cycle, accelerate the glycolytic flux, and reduce intracellular free glucose, thereby preventing its conversion to sorbitol.	Pentosephosphates	77-94	transketolase	Homo sapiens	14-27
16789437-1	2006	Glucose-6-phosphate dehydrogenase (G-6-PD) is the first enzyme in the pentose phosphate pathway.	Pentosephosphates	70-87	glucose-6-phosphate dehydrogenase	Homo sapiens	35-41
16492734-5	2006	Unexpectedly, gene array and functional analyses suggest that PPARdelta ameliorates hyperglycemia by increasing glucose flux through the pentose phosphate pathway and enhancing fatty acid synthesis.	Pentosephosphates	137-154	peroxisome proliferator activator receptor delta	Mus musculus	62-71
16470722-1	2006	Transaldolase (TAL) is a key enzyme of the pentose phosphate pathway (PPP).	Pentosephosphates	43-60	transaldolase 1	Mus musculus	0-13
16470722-1	2006	Transaldolase (TAL) is a key enzyme of the pentose phosphate pathway (PPP).	Pentosephosphates	43-60	transaldolase 1	Mus musculus	15-18
16213215-5	2005	We show that pentose-phosphate-pathway generation of NADPH is critical for oocyte survival and that the target of this regulation is caspase-2, previously shown to be required for oocyte death in mice.	Pentosephosphates	13-30	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	53-58
16421014-8	2006	Besides the enzymes directly involved in maintaining the normal redox status of the cell, glucose-6-phosphate dehydrogenase which catalyzes the first reaction of the pentose phosphate pathway, plays a key role in protection of the eye against reactive oxygen species.	Pentosephosphates	166-183	glucose-6-phosphate dehydrogenase	Homo sapiens	90-123
16274924-10	2005	For instance insulin dismissed by ejaculated spermatozoa up-regulates Glucose 6-Phosphate Dehydrogenase (G6PDH), the rate-limiting enzyme in the pentose phosphate pathway (PPP), which has be shown to be crucial in the acquisition of fertilizing capability as well as to mediate gamete fusion.	Pentosephosphates	145-162	insulin	Homo sapiens	13-20
16274924-10	2005	For instance insulin dismissed by ejaculated spermatozoa up-regulates Glucose 6-Phosphate Dehydrogenase (G6PDH), the rate-limiting enzyme in the pentose phosphate pathway (PPP), which has be shown to be crucial in the acquisition of fertilizing capability as well as to mediate gamete fusion.	Pentosephosphates	145-162	glucose-6-phosphate dehydrogenase	Homo sapiens	70-103
16274924-10	2005	For instance insulin dismissed by ejaculated spermatozoa up-regulates Glucose 6-Phosphate Dehydrogenase (G6PDH), the rate-limiting enzyme in the pentose phosphate pathway (PPP), which has be shown to be crucial in the acquisition of fertilizing capability as well as to mediate gamete fusion.	Pentosephosphates	145-162	glucose-6-phosphate dehydrogenase	Homo sapiens	105-110
16439706-1	2006	OBJECTIVE: Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway that is a major source of cellular NADPH.	Pentosephosphates	75-92	glucose-6-phosphate dehydrogenase 2	Mus musculus	11-44
16439706-1	2006	OBJECTIVE: Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway that is a major source of cellular NADPH.	Pentosephosphates	75-92	glucose-6-phosphate dehydrogenase 2	Mus musculus	46-50
16116031-10	2006	This ultrastructural localization is similar to that of glucose-6-phosphate dehydrogenase activity, suggesting activity of the pentose phosphate pathway at these sites.	Pentosephosphates	127-144	glucose-6-phosphate dehydrogenase	Rattus norvegicus	56-89
16213215-6	2005	Pentose-phosphate-pathway-mediated inhibition of cell death was due to the inhibitory phosphorylation of caspase-2 by calcium/calmodulin-dependent protein kinase II (CaMKII).	Pentosephosphates	0-17	caspase 2	Mus musculus	105-114
16213215-6	2005	Pentose-phosphate-pathway-mediated inhibition of cell death was due to the inhibitory phosphorylation of caspase-2 by calcium/calmodulin-dependent protein kinase II (CaMKII).	Pentosephosphates	0-17	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	118-164
16213215-6	2005	Pentose-phosphate-pathway-mediated inhibition of cell death was due to the inhibitory phosphorylation of caspase-2 by calcium/calmodulin-dependent protein kinase II (CaMKII).	Pentosephosphates	0-17	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	166-172
15994921-4	2005	K13 mutants display a modest increase in anaerobic glycolysis associated with a large increase in oxidative pentose phosphate pathway activity and pyruvate dehydrogenase flux.	Pentosephosphates	108-125	keratin 13	Mus musculus	0-3
16002431-3	2005	In the study of the pentose phosphate pathways, the need to consider isotope exchange reactions of transketolase (TK) and transaldolase (TA) (which in past analyses have often been ignored) magnifies this problem; but accounting for the interrelation between the fluxes known from biochemical studies and kinetic modeling solves it.	Pentosephosphates	20-37	transketolase	Homo sapiens	99-112
16002431-3	2005	In the study of the pentose phosphate pathways, the need to consider isotope exchange reactions of transketolase (TK) and transaldolase (TA) (which in past analyses have often been ignored) magnifies this problem; but accounting for the interrelation between the fluxes known from biochemical studies and kinetic modeling solves it.	Pentosephosphates	20-37	transketolase	Homo sapiens	114-116
16002431-3	2005	In the study of the pentose phosphate pathways, the need to consider isotope exchange reactions of transketolase (TK) and transaldolase (TA) (which in past analyses have often been ignored) magnifies this problem; but accounting for the interrelation between the fluxes known from biochemical studies and kinetic modeling solves it.	Pentosephosphates	20-37	transaldolase 1	Homo sapiens	122-135
16002431-3	2005	In the study of the pentose phosphate pathways, the need to consider isotope exchange reactions of transketolase (TK) and transaldolase (TA) (which in past analyses have often been ignored) magnifies this problem; but accounting for the interrelation between the fluxes known from biochemical studies and kinetic modeling solves it.	Pentosephosphates	20-37	transaldolase 1	Homo sapiens	137-139
16039947-9	2005	The pentose phosphate pathway and its regulatory enzyme glucose 6-phosphate dehydrogenase were markedly inhibited only by the natural specimen, which also caused a depletion of intracellular reduced glutathione in A549 cells.	Pentosephosphates	4-21	glucose-6-phosphate dehydrogenase	Homo sapiens	56-89
18220605-4	2005	The expression and activity of the thiamine-dependent enzyme, transketolase--the pacemaking enzyme of the reductive pentosephosphate pathway, is consequently decreased.	Pentosephosphates	116-132	transketolase	Homo sapiens	62-75
15998684-1	2005	BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) regulates production of the reduced form of NADPH through the pentose phosphate pathway.	Pentosephosphates	115-132	glucose-6-phosphate dehydrogenase 2	Mus musculus	12-45
15998684-1	2005	BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) regulates production of the reduced form of NADPH through the pentose phosphate pathway.	Pentosephosphates	115-132	glucose-6-phosphate dehydrogenase 2	Mus musculus	47-51
15896329-1	2005	6-Phosphogluconate dehydrogenase (6PGDH) constitutes the pentose phosphate pathway and produces NADPH.	Pentosephosphates	57-74	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	96-101
15705060-2	2005	The homologous mammalian enzyme, FN3K-RP (FN3K-related protein), does not phosphorylate fructosamines but ribulosamines, which are probably formed through a spontaneous reaction of amines with ribose 5-phosphate, an intermediate of the pentose-phosphate pathway and the Calvin cycle.	Pentosephosphates	236-253	fructosamine 3 kinase related protein	Homo sapiens	33-40
15705060-2	2005	The homologous mammalian enzyme, FN3K-RP (FN3K-related protein), does not phosphorylate fructosamines but ribulosamines, which are probably formed through a spontaneous reaction of amines with ribose 5-phosphate, an intermediate of the pentose-phosphate pathway and the Calvin cycle.	Pentosephosphates	236-253	fructosamine 3 kinase related protein	Homo sapiens	42-62
15872021-7	2005	We provide evidence that dysregulation of Nrf2 and the ARE, coupled with reduced pentose phosphate pathway activity and decreased generation of NADPH, represent significant and hitherto unrecognized components of the toxic gain of function of mutant SOD1.	Pentosephosphates	81-98	NFE2 like bZIP transcription factor 2	Homo sapiens	42-46
15872021-7	2005	We provide evidence that dysregulation of Nrf2 and the ARE, coupled with reduced pentose phosphate pathway activity and decreased generation of NADPH, represent significant and hitherto unrecognized components of the toxic gain of function of mutant SOD1.	Pentosephosphates	81-98	superoxide dismutase 1	Homo sapiens	250-254
16284727-9	2005	The relatively small Ki for the 6PGD:NADPH complex indicates the importance of NADPH in the regulation of the pentose phosphate pathway through G6PD and 6PGD.	Pentosephosphates	110-127	glucose-6-phosphate dehydrogenase	Rattus norvegicus	144-148
15858258-1	2005	Human glucose-6-phosphate dehydrogenase (G6PD) is NADP(+)-dependent and catalyses the first and rate-limiting step of the pentose phosphate shunt.	Pentosephosphates	122-139	glucose-6-phosphate dehydrogenase	Homo sapiens	6-39
15858258-1	2005	Human glucose-6-phosphate dehydrogenase (G6PD) is NADP(+)-dependent and catalyses the first and rate-limiting step of the pentose phosphate shunt.	Pentosephosphates	122-139	glucose-6-phosphate dehydrogenase	Homo sapiens	41-45
15619295-8	2005	10.21.2003 database with mass spectrometric data yielded the identity of 21 differentially translated proteins in Rst(2)DDT(91-R), Rst(2)DDT(Wisconsin) and Canton-S representing proteins putatively involved in biochemical pathways such as glycolysis and gluconeogenesis, the pentose phosphate pathway, the Krebs cycle and fatty acid oxidation.	Pentosephosphates	275-292	Rst(2)DDT-EMS2	Drosophila melanogaster	114-123
15550513-7	2005	Then we evaluated the autocrine effect of sperm insulin on glucose metabolism by studying the activity of glucose-6-phosphate dehydrogenase, the key rate-limiting enzyme in the pentose phosphate pathway.	Pentosephosphates	177-194	glucose-6-phosphate dehydrogenase	Homo sapiens	106-139
15793230-2	2005	Liver fatty acid synthase mRNA and fatty acid synthesis rates were dramatically increased in GLUT4 null mice compared with control mice and were supported by increased rates of the pentose phosphate pathway oxidative phase and sterol regulatory binding protein mRNA expression.	Pentosephosphates	181-198	fatty acid synthase	Mus musculus	6-25
15793230-2	2005	Liver fatty acid synthase mRNA and fatty acid synthesis rates were dramatically increased in GLUT4 null mice compared with control mice and were supported by increased rates of the pentose phosphate pathway oxidative phase and sterol regulatory binding protein mRNA expression.	Pentosephosphates	181-198	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	93-98
15722468-10	2005	We suggest that loss of GPT1 function results in disruption of the oxidative pentose phosphate cycle, which in turn affects fatty acid biosynthesis.	Pentosephosphates	77-94	glucose 6-phosphate/phosphate translocator 1	Arabidopsis thaliana	24-28
15760711-1	2005	Glucose-6-phosphate dehydrogenase is the key regulatory enzyme of the pentose phosphate pathway and one of the products of this enzyme; NADPH has a critical role in the defence system against the free radicals.	Pentosephosphates	70-87	glucose-6-phosphate dehydrogenase	Bos taurus	0-33
15619295-8	2005	10.21.2003 database with mass spectrometric data yielded the identity of 21 differentially translated proteins in Rst(2)DDT(91-R), Rst(2)DDT(Wisconsin) and Canton-S representing proteins putatively involved in biochemical pathways such as glycolysis and gluconeogenesis, the pentose phosphate pathway, the Krebs cycle and fatty acid oxidation.	Pentosephosphates	275-292	Rst(2)DDT-EMS2	Drosophila melanogaster	131-140
15528549-3	2004	In recombinant S. cerevisiae expressing XYL1, XYL2, and XYL3, mRNA transcript levels for glycolytic, fermentative, and pentose phosphate enzymes did not change significantly on glucose or xylose under aeration or oxygen limitation.	Pentosephosphates	119-136	D-xylulose reductase XYL2	Saccharomyces cerevisiae S288C	46-50
15358777-9	2004	We suggest that the DPI-elicited inhibition of the pentose phosphate pathway and tricarboxylic acid cycle may be mediated by the blockade of several NAD(P)-dependent enzymes, such as glucose 6-phosphate dehydrogenase, glyceraldehyde 3-phosphate dehydrogenase, and lactate dehydrogenase.	Pentosephosphates	51-68	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	218-258
15234979-7	2004	Glucose inhibited the response to H2O2 through its metabolism by the pentose phosphate pathway, as its effect was reversed by the glucose-6-phosphate dehydrogenase inhibitor dehydroepiandrosterone.	Pentosephosphates	69-86	glucose-6-phosphate dehydrogenase	Homo sapiens	130-163
15203119-5	2004	Exposure of intact red blood cells to beta-amyloid peptide (31-35) induced a marked stimulation (approximately 45%) of the pentose phosphate pathway and a significant inhibition of the red cell enzyme catalase, compared with the results observed in control red blood cells.	Pentosephosphates	123-140	amyloid beta precursor protein	Homo sapiens	38-58
15189835-1	2004	Glutathione peroxidase is one of the principal antioxidant defense enzymes in human spermatozoa, but it requires oxidized glutathione to be reduced by glutathione reductase using NADPH generated in the pentose phosphate pathway.	Pentosephosphates	202-219	glutathione-disulfide reductase	Homo sapiens	151-172
15189835-6	2004	At concentrations of 50 microg/ml or greater, the glutathione reductase-inhibitor 1,3-bis-(2-chloroethyl) 1-nitrosourea decreased flux through the pentose phosphate pathway and blocked the response to cumene hydroperoxide.	Pentosephosphates	147-164	glutathione-disulfide reductase	Homo sapiens	50-71
15189835-8	2004	These data show that the pentose phosphate pathway in human spermatozoa can respond dynamically to oxidative stress and that inhibiting glutathione reductase impairs the ability of sperm to resist lipid peroxidation.	Pentosephosphates	25-42	glutathione-disulfide reductase	Homo sapiens	136-157
15189835-9	2004	We conclude that the glutathione peroxidase-glutathione reductase-pentose phosphate pathway system is functional and provides an effective antioxidant defense in normal human spermatozoa.	Pentosephosphates	66-83	glutathione-disulfide reductase	Homo sapiens	44-65
15506519-1	2004	Glucose 6-phosphate dehydrogenase (G6PD) catalyses the first step of the pentose phosphate pathway, which in the RBC leads to the formation of NADPH, essential to prevent the cell from an oxidative stress.	Pentosephosphates	73-90	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
15454531-3	2004	SOL1-SOL4 are homologous to genes encoding 6-phosphogluconolactonase (6Pgl) involved in the pentose phosphate pathway.	Pentosephosphates	92-109	Sol1p	Saccharomyces cerevisiae S288C	0-4
15454531-3	2004	SOL1-SOL4 are homologous to genes encoding 6-phosphogluconolactonase (6Pgl) involved in the pentose phosphate pathway.	Pentosephosphates	92-109	6-phosphogluconolactonase SOL4	Saccharomyces cerevisiae S288C	5-9
15506519-1	2004	Glucose 6-phosphate dehydrogenase (G6PD) catalyses the first step of the pentose phosphate pathway, which in the RBC leads to the formation of NADPH, essential to prevent the cell from an oxidative stress.	Pentosephosphates	73-90	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
15296642-1	2004	The metabolic enzyme transketolase (TK) plays a crucial role in tumor cell nucleic acid synthesis, using glucose through the elevated nonoxidative pentose phosphate pathway (PPP).	Pentosephosphates	147-164	transketolase	Homo sapiens	21-34
15621740-1	2004	Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme of the pentose phosphate shunt pathway a major function of which is to prevent cellular oxidative damage.	Pentosephosphates	61-78	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
15621740-1	2004	Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme of the pentose phosphate shunt pathway a major function of which is to prevent cellular oxidative damage.	Pentosephosphates	61-78	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
15296642-1	2004	The metabolic enzyme transketolase (TK) plays a crucial role in tumor cell nucleic acid synthesis, using glucose through the elevated nonoxidative pentose phosphate pathway (PPP).	Pentosephosphates	147-164	transketolase	Homo sapiens	36-38
13679042-5	2003	This ratio was favorable to the pentosephosphate pathway by the addition of high excess of exogenous glucose-6-phosphate dehydrogenase, standardly used for the activity assay of hexokinase, but still a significant part (17+/-3%) of the common intermediate was converted into the direction of glycolysis.	Pentosephosphates	32-48	glucose-6-phosphate dehydrogenase	Homo sapiens	101-134
14702349-1	2004	Transaldolase regulates redox-dependent apoptosis through controlling NADPH and ribose 5-phosphate production via the pentose phosphate pathway.	Pentosephosphates	118-135	transaldolase 1	Homo sapiens	0-13
14757696-4	2004	Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway, generates NADPH in a reaction linked to the de novo production of ribose.	Pentosephosphates	74-91	glucose-6-phosphate dehydrogenase 2	Mus musculus	35-39
15082106-4	2004	The latter is produced in the pentose phosphate pathway that requires normal activity of glucose 6 phosphate dehydrogenase (G6PD).	Pentosephosphates	30-47	glucose-6-phosphate dehydrogenase	Homo sapiens	89-122
15082106-4	2004	The latter is produced in the pentose phosphate pathway that requires normal activity of glucose 6 phosphate dehydrogenase (G6PD).	Pentosephosphates	30-47	glucose-6-phosphate dehydrogenase	Homo sapiens	124-128
15269432-11	2004	The S. cerevisiae pentose phosphate pathway genes RK11, RPE1, TAL1, and TKL1 were cloned in pB3 PGK and integrated in the locus of the respective gene, resulting in simultaneous overexpression of the genes in the xylose-fermenting S. cerevisiae strain TMB3001.	Pentosephosphates	18-35	ribulose-phosphate 3-epimerase RPE1	Saccharomyces cerevisiae S288C	56-60
15269432-11	2004	The S. cerevisiae pentose phosphate pathway genes RK11, RPE1, TAL1, and TKL1 were cloned in pB3 PGK and integrated in the locus of the respective gene, resulting in simultaneous overexpression of the genes in the xylose-fermenting S. cerevisiae strain TMB3001.	Pentosephosphates	18-35	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1	Saccharomyces cerevisiae S288C	62-66
15269432-11	2004	The S. cerevisiae pentose phosphate pathway genes RK11, RPE1, TAL1, and TKL1 were cloned in pB3 PGK and integrated in the locus of the respective gene, resulting in simultaneous overexpression of the genes in the xylose-fermenting S. cerevisiae strain TMB3001.	Pentosephosphates	18-35	transketolase TKL1	Saccharomyces cerevisiae S288C	72-76
12943535-8	2003	In addition, ALDH3A1 metabolized glyceraldehyde poorly and did not metabolize glucose 6-phosphate, 6-phosphoglucono-delta-lactone and 6-phosphogluconate at all, suggesting that this enzyme is not involved in either glycolysis or the pentose phosphate pathway.	Pentosephosphates	233-250	aldehyde dehydrogenase 3 family member A1	Homo sapiens	13-20
14644433-0	2003	Insulin stimulates glucose metabolism via the pentose phosphate pathway in Drosophila Kc cells.	Pentosephosphates	46-63	Insulin-like receptor	Drosophila melanogaster	0-7
14644433-5	2003	Thus, insulin-stimulated glucose oxidation did not occur via increasing Krebs cycle activity but rather by stimulating the pentose phosphate pathway.	Pentosephosphates	123-140	Insulin-like receptor	Drosophila melanogaster	6-13
14644433-6	2003	Indeed, inhibition of the oxidative pentose phosphate pathway by 6-aminonicotinamide abolished the effect of insulin on (14)CO(2) from D-[U-(14)C]glucose.	Pentosephosphates	36-53	Insulin-like receptor	Drosophila melanogaster	109-116
14613721-7	2003	Our data provide also a mechanism by which asbestos fibers inhibit the pentose phosphate pathway, i.e., via the oxidative inhibition of glucose 6-phosphate dehydrogenase, which is prevented by reduced glutathione.	Pentosephosphates	71-88	glucose-6-phosphate dehydrogenase	Homo sapiens	136-169
15182299-11	2004	We propose that glycolysis in Gpi1-negative cells proceeds entirely through the pentose phosphate pathway, creating NADPH at the cost of organic carbon.	Pentosephosphates	80-97	glucose-6-phosphate isomerase 1	Mus musculus	30-34
15197729-6	2004	Also, most of the structural genes involved in trehalose and glycogen synthesis and a few genes in the glyoxylate cycle and the pentose phosphate pathway are derepressed in the ssy1 and stp1 stp2 strains.	Pentosephosphates	128-145	Ssy1p	Saccharomyces cerevisiae S288C	177-181
15197729-6	2004	Also, most of the structural genes involved in trehalose and glycogen synthesis and a few genes in the glyoxylate cycle and the pentose phosphate pathway are derepressed in the ssy1 and stp1 stp2 strains.	Pentosephosphates	128-145	Stp1p	Saccharomyces cerevisiae S288C	186-195
15039952-0	2004	Effects of oxidative stress and inhibitors of the pentose phosphate pathway on sexually dimorphic production of IFN-tau by bovine blastocysts.	Pentosephosphates	50-67	interferon tau-2	Bos taurus	112-119
15039952-4	2004	The second is that female EB produce more IFN-tau because pentose-phosphate pathway (PPP) activity is elevated as a result of delayed X-chromosome inactivation.	Pentosephosphates	58-75	interferon tau-2	Bos taurus	42-49
14988808-0	2004	Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowly progressive leukoencephalopathy.	Pentosephosphates	65-82	ribose 5-phosphate isomerase A	Homo sapiens	0-28
14988808-3	2004	Deficient activity of RPI, one of the pentose-phosphate-pathway (PPP) enzymes, was demonstrated in fibroblasts.	Pentosephosphates	38-55	ribose 5-phosphate isomerase A	Homo sapiens	22-25
15047603-12	2004	In addition, FXR is regulated by glucose likely via the pentose phosphate pathway.	Pentosephosphates	56-73	nuclear receptor subfamily 1, group H, member 4	Rattus norvegicus	13-16
13679042-5	2003	This ratio was favorable to the pentosephosphate pathway by the addition of high excess of exogenous glucose-6-phosphate dehydrogenase, standardly used for the activity assay of hexokinase, but still a significant part (17+/-3%) of the common intermediate was converted into the direction of glycolysis.	Pentosephosphates	32-48	hexokinase 1	Homo sapiens	178-188
12777375-1	2003	Glucose-6-phosphate dehydrogenase (G6PD), the first enzyme of the pentose phosphate pathway, is the principal intracellular source of NADPH.	Pentosephosphates	66-83	glucose-6-phosphate dehydrogenase 2	Mus musculus	0-33
14532041-4	2003	NADPH is normally generated through the oxidative part of the pentose phosphate pathway by the action of glucose-6-phosphate dehydrogenase (ZWF1).	Pentosephosphates	62-79	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	105-138
14532041-4	2003	NADPH is normally generated through the oxidative part of the pentose phosphate pathway by the action of glucose-6-phosphate dehydrogenase (ZWF1).	Pentosephosphates	62-79	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	140-144
12829617-5	2003	Glucose-6-phosphate dehydrogenase (G6PD) functions as the first and rate-limiting enzyme in the pentose phosphate pathway, responsible for the generation of NADPH in a reaction coupled to the de novo production of cellular ribose.	Pentosephosphates	96-113	glucose-6-phosphate dehydrogenase 2	Mus musculus	0-33
12829617-5	2003	Glucose-6-phosphate dehydrogenase (G6PD) functions as the first and rate-limiting enzyme in the pentose phosphate pathway, responsible for the generation of NADPH in a reaction coupled to the de novo production of cellular ribose.	Pentosephosphates	96-113	glucose-6-phosphate dehydrogenase 2	Mus musculus	35-39
19002931-6	2003	The activity of glucose-6-phosphate dehydrogenase and pyruvate carboxylase in CHO cells was also increased whilst lactate dehydrogenase activity remained unaltered, suggesting an increased flux to the pentose phosphate pathway and TCA cycle, respectively.	Pentosephosphates	201-218	glucose-6-phosphate 1-dehydrogenase	Cricetulus griseus	16-49
19002931-6	2003	The activity of glucose-6-phosphate dehydrogenase and pyruvate carboxylase in CHO cells was also increased whilst lactate dehydrogenase activity remained unaltered, suggesting an increased flux to the pentose phosphate pathway and TCA cycle, respectively.	Pentosephosphates	201-218	pyruvate carboxylase, mitochondrial	Cricetulus griseus	54-74
12777375-1	2003	Glucose-6-phosphate dehydrogenase (G6PD), the first enzyme of the pentose phosphate pathway, is the principal intracellular source of NADPH.	Pentosephosphates	66-83	glucose-6-phosphate dehydrogenase 2	Mus musculus	35-39
12969300-6	2003	SIGNIFICANCE AND IMPACT OF THE STUDY: Overexpression of the XKS1 gene made xylulose fermentation process accelerated to produce ethanol through the pentose phosphate pathway.	Pentosephosphates	148-165	xylulokinase	Saccharomyces cerevisiae S288C	60-64
12584194-3	2003	The major enzymatic source of NADPH in the cell is the reaction catalyzed by glucose-6-phosphate dehydrogenase, the first enzyme in the pentose phosphate pathway.	Pentosephosphates	136-153	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	77-110
12570990-9	2003	Microarray analysis showed higher expression in S. cerevisiae TMB 3400 than in S. cerevisiae TMB 3399 for (i) HXT5, encoding a hexose transporter; (ii) XKS1, encoding xylulokinase, an enzyme involved in one of the initial steps of xylose utilization; and (iii) SOL3, GND1, TAL1, and TKL1, encoding enzymes in the pentose phosphate pathway.	Pentosephosphates	313-330	hexose transporter HXT5	Saccharomyces cerevisiae S288C	110-114
12643793-15	2003	Deprivation of glucose, which provides the substrate for G6PD in the oxidative pentose phosphate cycle, decreased the rate of bioreduction of HEDS and lipoate in G6PD-containing cells to the level in G6PD-deficient cells.	Pentosephosphates	79-96	glucose-6-phosphate 1-dehydrogenase	Cricetulus griseus	57-61
12643793-15	2003	Deprivation of glucose, which provides the substrate for G6PD in the oxidative pentose phosphate cycle, decreased the rate of bioreduction of HEDS and lipoate in G6PD-containing cells to the level in G6PD-deficient cells.	Pentosephosphates	79-96	glucose-6-phosphate 1-dehydrogenase	Cricetulus griseus	162-166
12570990-9	2003	Microarray analysis showed higher expression in S. cerevisiae TMB 3400 than in S. cerevisiae TMB 3399 for (i) HXT5, encoding a hexose transporter; (ii) XKS1, encoding xylulokinase, an enzyme involved in one of the initial steps of xylose utilization; and (iii) SOL3, GND1, TAL1, and TKL1, encoding enzymes in the pentose phosphate pathway.	Pentosephosphates	313-330	xylulokinase	Saccharomyces cerevisiae S288C	152-156
12700644-4	2003	This elevated expression of Hsps is paralleled by an increased activity of mitochondrial metabolism and pentose phosphate pathway, this latter leading to high levels of glucose-6-phosphate dehydrogenase and, consequently, of glutathione.	Pentosephosphates	104-121	glucose-6-phosphate dehydrogenase	Homo sapiens	169-202
12417006-11	2002	The greater relative activity of glucose-6-phosphate dehydrogenase recorded in the oocyte indicates that glucose uptake could be directed mainly toward the pentose phosphate pathway.	Pentosephosphates	156-173	glucose-6-phosphate dehydrogenase	Bos taurus	33-66
12393032-1	2002	Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of the pentose phosphate pathway in carbohydrate metabolism.	Pentosephosphates	66-83	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-33
12393032-1	2002	Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of the pentose phosphate pathway in carbohydrate metabolism.	Pentosephosphates	66-83	glucose-6-phosphate dehydrogenase	Rattus norvegicus	35-39
12459274-1	2002	Transaldolase (TAL) is an enzyme of the non-oxidative part of the pentose phosphate pathway which produces reductive potential in the form of NADPH as well as ribose 5-phosphate for incorporation into nucleotides.	Pentosephosphates	66-83	Transaldolase	Drosophila melanogaster	0-13
12502759-2	2003	In this study, the kinetic properties of G6PD activity were determined in situ in chemically induced hepatocellular carcinomas, and extralesional and control parenchyma in rat livers and were directly compared with those of the second NADPH-producing enzyme of the pentose phosphate pathway, phosphogluconate dehydrogenase (PGD).	Pentosephosphates	265-282	glucose-6-phosphate dehydrogenase	Rattus norvegicus	41-45
14978897-4	2003	Glucose-6-phosphate dehydrogenase (G6PDH), an enzyme of pentose phosphate pathway, is responsible for the regeneration of G6PDH, the main cellular reductant.	Pentosephosphates	56-73	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
14978897-4	2003	Glucose-6-phosphate dehydrogenase (G6PDH), an enzyme of pentose phosphate pathway, is responsible for the regeneration of G6PDH, the main cellular reductant.	Pentosephosphates	56-73	glucose-6-phosphate dehydrogenase	Homo sapiens	35-40
14978897-4	2003	Glucose-6-phosphate dehydrogenase (G6PDH), an enzyme of pentose phosphate pathway, is responsible for the regeneration of G6PDH, the main cellular reductant.	Pentosephosphates	56-73	glucose-6-phosphate dehydrogenase	Homo sapiens	122-127
12459274-1	2002	Transaldolase (TAL) is an enzyme of the non-oxidative part of the pentose phosphate pathway which produces reductive potential in the form of NADPH as well as ribose 5-phosphate for incorporation into nucleotides.	Pentosephosphates	66-83	Transaldolase	Drosophila melanogaster	15-18
12215204-3	2002	DHA at 200-1,000 microM stimulated activity of pentose phosphate pathway enzymes glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and transaldolase, elevated intracellular glutathione levels, and inhibited H(2)O(2)-induced changes in mitochondrial transmembrane potential and cell death.	Pentosephosphates	47-64	glucose-6-phosphate dehydrogenase	Homo sapiens	81-114
12212724-5	2002	The activities of the glycolytic enzymes glucose-6-phosphate dehydrogenase (G6PD) for the pentose phosphate pathway and malate dehydrogenase (MDH) for the malate-aspartate shuttle, and the expression of the mRNA of cytosolic MDH were significantly increased in the testicular tissues of dogs with seminoma.	Pentosephosphates	90-107	glucose-6-phosphate dehydrogenase	Canis lupus familiaris	76-80
12498092-1	2002	The activities of key enzymes of pentose phosphate pathway, glucose-6-phosphate dehydrogenase (G-6 PD) and 6-phosphogluconate dehydrogenase (6-PGD), were studied in cytoplasmatic fractions of brain cortical (limbic, orbital, sensorimotor cortex) and subcortical (myelencefalon, mesencefalon, hypothalamus) structures of rats subjected to starvation for 1, 2, 3, 5 and 7 days.	Pentosephosphates	33-50	glucose-6-phosphate dehydrogenase	Rattus norvegicus	60-93
12498092-1	2002	The activities of key enzymes of pentose phosphate pathway, glucose-6-phosphate dehydrogenase (G-6 PD) and 6-phosphogluconate dehydrogenase (6-PGD), were studied in cytoplasmatic fractions of brain cortical (limbic, orbital, sensorimotor cortex) and subcortical (myelencefalon, mesencefalon, hypothalamus) structures of rats subjected to starvation for 1, 2, 3, 5 and 7 days.	Pentosephosphates	33-50	glucose-6-phosphate dehydrogenase	Rattus norvegicus	95-101
12072725-2	2002	To clarify the relevance of the pentose phosphate pathway to their antioxidant defense, we examined the activity of glucose-6-phosphate dehydrogenase (G6PDH), the rate-determining enzyme of the pathway, in corneas exposed to ultraviolet light (UV).	Pentosephosphates	32-49	glucose-6-phosphate dehydrogenase	Homo sapiens	151-156
12072725-11	2002	CONCLUSION: Exposure of corneas to UVA or a small dose of UVC enhances the G6PDH activity, i.e., the pentose phosphate pathway.	Pentosephosphates	101-118	glucose-6-phosphate dehydrogenase	Homo sapiens	75-80
12215204-3	2002	DHA at 200-1,000 microM stimulated activity of pentose phosphate pathway enzymes glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and transaldolase, elevated intracellular glutathione levels, and inhibited H(2)O(2)-induced changes in mitochondrial transmembrane potential and cell death.	Pentosephosphates	47-64	transaldolase 1	Homo sapiens	154-167
11842155-7	2002	Database analysis revealed that plant cells contain, in addition to enzymes of the oxidative branch of the oxidative pentose phosphate pathway, ribose 5-phosphate isomerase and ribulose 5-phosphate epimerase in both the cytosol and the plastids, whereas the transketolase and transaldolase converting the produced pentose phosphates to triose phosphates and hexose phosphates are probably solely confined to plastids.	Pentosephosphates	117-134	Ribose 5-phosphate isomerase, type A protein	Arabidopsis thaliana	144-172
11916674-4	2002	The pentose phosphate pathway was blocked either by disruption of the GND1 gene, one of the isogenes of 6-phosphogluconate dehydrogenase, or by disruption of the ZWF1 gene, which encodes glucose 6-phosphate dehydrogenase.	Pentosephosphates	4-21	phosphogluconate dehydrogenase (decarboxylating) GND1	Saccharomyces cerevisiae S288C	70-74
11916674-4	2002	The pentose phosphate pathway was blocked either by disruption of the GND1 gene, one of the isogenes of 6-phosphogluconate dehydrogenase, or by disruption of the ZWF1 gene, which encodes glucose 6-phosphate dehydrogenase.	Pentosephosphates	4-21	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	162-166
11916674-4	2002	The pentose phosphate pathway was blocked either by disruption of the GND1 gene, one of the isogenes of 6-phosphogluconate dehydrogenase, or by disruption of the ZWF1 gene, which encodes glucose 6-phosphate dehydrogenase.	Pentosephosphates	4-21	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	187-220
11788599-1	2002	Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the oxidative pentose phosphate cycle, regulates the NADPH/NADP(+) ratio in eukaryotic cells.	Pentosephosphates	84-101	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
11788599-1	2002	Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the oxidative pentose phosphate cycle, regulates the NADPH/NADP(+) ratio in eukaryotic cells.	Pentosephosphates	84-101	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
11842155-7	2002	Database analysis revealed that plant cells contain, in addition to enzymes of the oxidative branch of the oxidative pentose phosphate pathway, ribose 5-phosphate isomerase and ribulose 5-phosphate epimerase in both the cytosol and the plastids, whereas the transketolase and transaldolase converting the produced pentose phosphates to triose phosphates and hexose phosphates are probably solely confined to plastids.	Pentosephosphates	314-332	Ribose 5-phosphate isomerase, type A protein	Arabidopsis thaliana	144-172
11368871-2	2001	These steroids are potent uncompetitive inhibitors of mammalian glucose-6-phosphate dehydrogenase, the first enzyme in the pentose phosphate pathway.	Pentosephosphates	123-140	glucose-6-phosphate dehydrogenase	Homo sapiens	64-97
11520909-5	2001	The inhibition of gap junctions increased the rate of glucose incorporation into DNA and RNA, which was inhibited by treatment with dehydroepiandrosterone, an inhibitor of glucose-6-phosphate dehydrogenase, the regulatory enzyme of the pentose phosphate pathway.	Pentosephosphates	236-253	glucose-6-phosphate dehydrogenase	Homo sapiens	172-205
12472120-2	2002	Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of the pentose phosphate pathway in carbohydrate metabolism, and it plays an important role in cell proliferation and antioxidant regulation within cells in various organs.	Pentosephosphates	66-83	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-33
12472120-2	2002	Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of the pentose phosphate pathway in carbohydrate metabolism, and it plays an important role in cell proliferation and antioxidant regulation within cells in various organs.	Pentosephosphates	66-83	glucose-6-phosphate dehydrogenase	Rattus norvegicus	35-39
11461146-10	2001	Intracellular metabolite analyses and in vitro enzyme activities suggest the following: the control of flux in a strain that overexpresses XKS1 has shifted to the nonoxidative steps of the pentose phosphate pathway (i.e., downstream of xylose 5-phosphate), and enzymatic steps in the lower part of glycolysis and ethanol formation pathways (pyruvate kinase, pyruvate decarboxylase, and alcohol dehydrogenase) do not have a high flux control in this recombinant strain.	Pentosephosphates	189-206	xylulokinase	Saccharomyces cerevisiae S288C	139-143
11390181-4	2001	Here we have analyzed transaldolase, which regulates NADPH levels produced by the pentose phosphate pathway in order to examine how it influences the catalase activity regulated in XP and SV40-transformed cells.	Pentosephosphates	82-99	transaldolase 1	Homo sapiens	22-35
11116398-4	2001	Analysis of specific activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase of the pentose phosphate pathway showed the upward regulation of alternate pathways of carbohydrate metabolism under cold stress to rapidly generate energy to overcome the stress.	Pentosephosphates	113-130	glucose-6-phosphate dehydrogenase	Homo sapiens	35-68
11275553-2	2001	A strategy to counter this is to stimulate the anaerobic pentosephosphate pathway of glycolysis by maximizing transketolase activity by thiamine supplementation, with the consequent consumption of glyceraldehyde-3-phosphate and increased formation of ribose-5-phosphate.	Pentosephosphates	57-73	transketolase	Homo sapiens	110-123
11087741-6	2001	Inhibition of the oxidative and the nonoxidative branches of the pentose phosphate pathway blocked the stimulation of glucose-6-phosphatase expression by glucose but not by xylitol or carbohydrates that enter the glycolytic/gluconeogenic pathways at the level of the triose phosphates.	Pentosephosphates	65-82	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	118-139
11215514-3	2000	These insulin-like actions include stimulating glucose uptake and regulating metabolic processes such as glycolysis, gluconeogenesis, fatty acid synthesis and the pentose phosphate pathway.	Pentosephosphates	163-180	insulin	Homo sapiens	6-13
11311853-12	2001	The small dissociation constant for the G6PD:NADPH complex pointed to tight enzyme:NADPH binding and the important role of NADPH in the regulation of the pentose phosphate pathway.	Pentosephosphates	154-171	glucose-6-phosphate dehydrogenase	Homo sapiens	40-44
10600882-5	1999	In BPA the relaxation to SNAP was not altered by FeCN, inhibitors of NADPH generation by the pentose phosphate pathway [250 microM 6-aminonicotinamide (6-AN) and 100 microM epiandrosterone (Epi)], or 1 microM DPI.	Pentosephosphates	93-110	2,4-dienoyl-CoA reductase 1	Homo sapiens	69-74
11072071-4	2000	To date, we have localized three enzymes in vanadocytes: 6-phosphogluconate dehydrogenase (6-PGDH: EC 1.1.1.44), glucose-6-phosphate dehydrogenase (G6PDH: EC 1.1.1.49), and glycogen phosphorylase (GP: EC 2.4.1.1), all of which are involved in the pentose phosphate pathway.	Pentosephosphates	247-264	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	148-153
11072071-5	2000	In the current study, we cloned a cDNA for transketolase, an essential and rate-limiting enzyme in the non-oxidative part of the pentose phosphate pathway, from vanadocytes.	Pentosephosphates	129-146	transketolase	Homo sapiens	43-56
11023706-3	2000	dHGF also increased the gene expression and enzyme activity of glucose-6-phosphate dehydrogenase, a rate-limiting enzyme of the pentose phosphate pathway, in hepatocytes.	Pentosephosphates	128-145	glucose-6-phosphate dehydrogenase	Rattus norvegicus	63-96
11229368-10	2000	Generation of GSH and TRX from their corresponding oxidized forms is dependent on NADPH provided through the pentose phosphate pathway of glucose metabolism.	Pentosephosphates	109-126	thioredoxin	Homo sapiens	22-25
11034341-4	2000	This feature is related to the activation of the oxidative branch of the pentose phosphate pathway and the increased production of NADPH.	Pentosephosphates	73-90	2,4-dienoyl-CoA reductase 1	Homo sapiens	131-136
10997684-2	2000	Our previous work has implicated aldose reductase in a pathway whereby aldose reductase-induced use of nicotinamide adenine dinucleotide phosphate (reduced form) (NADPH) drives the pentose phosphate pathway, which culminates in a protein kinase C-induced increase in glomerular prostaglandin production and loss of mesangial cell contractility as a possible cause of hyperfiltration and glomerular dysfunction in diabetes.	Pentosephosphates	181-198	aldo-keto reductase family 1 member B	Homo sapiens	33-49
10997684-2	2000	Our previous work has implicated aldose reductase in a pathway whereby aldose reductase-induced use of nicotinamide adenine dinucleotide phosphate (reduced form) (NADPH) drives the pentose phosphate pathway, which culminates in a protein kinase C-induced increase in glomerular prostaglandin production and loss of mesangial cell contractility as a possible cause of hyperfiltration and glomerular dysfunction in diabetes.	Pentosephosphates	181-198	aldo-keto reductase family 1 member B	Homo sapiens	71-87
10825753-1	2000	The initial and rate-limiting enzyme of the oxidative pentose phosphate shunt, glucose-6-phosphate dehydrogenase (G6PD), is inhibited by NADPH and stimulated by NADP(+).	Pentosephosphates	54-71	glucose-6-phosphate 1-dehydrogenase	Cricetulus griseus	79-112
10825753-1	2000	The initial and rate-limiting enzyme of the oxidative pentose phosphate shunt, glucose-6-phosphate dehydrogenase (G6PD), is inhibited by NADPH and stimulated by NADP(+).	Pentosephosphates	54-71	glucose-6-phosphate 1-dehydrogenase	Cricetulus griseus	114-118
10803891-2	2000	Overexpression of the gene (XKS1) for the pentose phosphate pathway (PPP) enzyme xylulokinase (XK) increased the ethanol yield by almost 85% and resulted in ethanol yields [0.61 C-mmol (C-mmol consumed xylulose)(-1)] that were close to the theoretical yield [0.67 C-mmol (C-mmol consumed xylulose)(-1)].	Pentosephosphates	42-59	xylulokinase	Saccharomyces cerevisiae S288C	28-32
10746800-3	2000	Glycolysis and the oxidative pentose phosphate pathway generate NADH and NADPH to reduce methemoglobin, which is being continuously produced, and the antioxidant glutathione, which is present in high concentrations.	Pentosephosphates	29-46	hemoglobin subunit gamma 2	Homo sapiens	89-102
10794725-2	2000	The binding of lcACoA esters by ACBP stimulated the utilization of Glc6P for fatty acid synthesis, starch synthesis and reductant supply via the oxidative pentose phosphate (OPP) pathway.	Pentosephosphates	155-172	acyl-CoA-binding protein	Brassica napus	32-36
10518023-2	1999	The protein was expressed in Escherichia coli, purified and shown to be 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway.	Pentosephosphates	144-161	6-phosphogluconolactonase	Homo sapiens	72-97
10510282-1	1999	We analyzed glucose-6-phosphate dehydrogenase, the rate-controlling enzyme of the pentose phosphate pathway and free sulfhydryls, to study redox balance in Alzheimer disease.	Pentosephosphates	82-99	glucose-6-phosphate dehydrogenase	Homo sapiens	12-45
10518023-0	1999	Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway(1).	Pentosephosphates	114-131	6-phosphogluconolactonase	Homo sapiens	42-67
10077634-6	1999	Inhibition of inducible PFK-2 protein expression decreased the intracellular level of 5-phosphoribosyl-1-pyrophosphate, a product of the pentose phosphate pathway and an important precursor for nucleic acid biosynthesis.	Pentosephosphates	137-154	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	24-29
10330104-15	1999	In addition, induction of maturation by FSH, hCG, or pyrroline carboxylate was accompanied by a significant increase in the oxidation of [1-14C]glucose but not [6-14C]glucose by OCC, supporting a proposed role for the pentose phosphate pathway in meiotic induction.	Pentosephosphates	218-235	hypertrichosis 2 (generalised, congenital)	Homo sapiens	45-48
10459841-9	1999	GSH-dependent peroxide metabolism is linked to the pentose phosphate shunt via NADPH-dependent glutathione reductase (GR).	Pentosephosphates	51-68	glutathione-disulfide reductase	Homo sapiens	95-116
10459841-9	1999	GSH-dependent peroxide metabolism is linked to the pentose phosphate shunt via NADPH-dependent glutathione reductase (GR).	Pentosephosphates	51-68	glutathione-disulfide reductase	Homo sapiens	118-120
10098886-1	1999	Treatment of cultured rat astrocytes with lipopolysaccharide (LPS; 1 microg/ml) increased mRNA expression of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting step in the pentose phosphate pathway (PPP), in a time-dependent fashion (0-24 h).	Pentosephosphates	181-198	glucose-6-phosphate dehydrogenase	Rattus norvegicus	109-142
10329961-2	1999	The principal intracellular reductant NADPH is mainly produced by the pentose phosphate pathway by glucose-6-phosphate dehydrogenase (G6PDH), the rate-limiting enzyme, and by 6-phosphogluconate dehydrogenase.	Pentosephosphates	70-87	glucose-6-phosphate dehydrogenase	Homo sapiens	99-132
10329961-2	1999	The principal intracellular reductant NADPH is mainly produced by the pentose phosphate pathway by glucose-6-phosphate dehydrogenase (G6PDH), the rate-limiting enzyme, and by 6-phosphogluconate dehydrogenase.	Pentosephosphates	70-87	glucose-6-phosphate dehydrogenase	Homo sapiens	134-139
10098886-1	1999	Treatment of cultured rat astrocytes with lipopolysaccharide (LPS; 1 microg/ml) increased mRNA expression of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting step in the pentose phosphate pathway (PPP), in a time-dependent fashion (0-24 h).	Pentosephosphates	181-198	glucose-6-phosphate dehydrogenase	Rattus norvegicus	144-148
10099575-9	1999	In addition mass distributions of metabolites are significantly influenced over a broad range by the degree of reversibility of transaldolase and transketolase reactions in the pentosephosphate pathway.	Pentosephosphates	177-193	transaldolase 1	Homo sapiens	128-141
10099575-9	1999	In addition mass distributions of metabolites are significantly influenced over a broad range by the degree of reversibility of transaldolase and transketolase reactions in the pentosephosphate pathway.	Pentosephosphates	177-193	transketolase	Homo sapiens	146-159
9843485-5	1998	It encodes a protein similar to the D-ribulose-5-phosphate 3-epimerase (RPE) (EC 5.1.3.1), a key enzyme in the reductive Calvin cycle and the oxidative pentose phosphate pathway (OPPP).	Pentosephosphates	152-169	D-ribulose-5-phosphate-3-epimerase	Arabidopsis thaliana	36-70
10082871-5	1999	Since G6PD regulates the flux through the hexose monophosphate shunt (HMS) pathway, which provides NADPH for reductive biosynthesis and pentose phosphates for nucleic acid formation, it can be concluded that high G6PD activity in periglomerular neurons is functional to their differentiating capability.	Pentosephosphates	136-154	glucose-6-phosphate dehydrogenase	Rattus norvegicus	6-10
10082871-5	1999	Since G6PD regulates the flux through the hexose monophosphate shunt (HMS) pathway, which provides NADPH for reductive biosynthesis and pentose phosphates for nucleic acid formation, it can be concluded that high G6PD activity in periglomerular neurons is functional to their differentiating capability.	Pentosephosphates	136-154	glucose-6-phosphate dehydrogenase	Rattus norvegicus	213-217
9915806-1	1999	Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of the pentose phosphate pathway that is responsible for the generation of NADPH, which is required in many detoxifying reactions.	Pentosephosphates	66-83	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
9915806-1	1999	Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of the pentose phosphate pathway that is responsible for the generation of NADPH, which is required in many detoxifying reactions.	Pentosephosphates	66-83	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
9920387-6	1998	The data suggest that the activity of 6PGDH is subjected to a two-way regulation: NADPH, which regulates the pentose phosphate pathway, inhibits the enzyme, while 6-phosphogluconate, levels of which rise when NADPH inhibition is removed, acts as an activator ensuring that 6-phosphogluconate is rapidly removed.	Pentosephosphates	109-126	6-phosphogluconate dehydrogenase, decarboxylating	Ovis aries	38-43
9843485-5	1998	It encodes a protein similar to the D-ribulose-5-phosphate 3-epimerase (RPE) (EC 5.1.3.1), a key enzyme in the reductive Calvin cycle and the oxidative pentose phosphate pathway (OPPP).	Pentosephosphates	152-169	D-ribulose-5-phosphate-3-epimerase	Arabidopsis thaliana	72-75
9636671-5	1998	Results point to NAD kinase as the source generator of this anchoring and linking cofactor for the oxidative stress and pentose phosphate enzyme systems, respectively.	Pentosephosphates	120-137	NAD kinase	Bos taurus	17-27
9924800-12	1998	The cornea contains a particularly high transketolase concentration, consistent with the proposal that pentose phosphate pathway activity has a role in the removal of light-generated radicals.	Pentosephosphates	103-120	transketolase	Homo sapiens	40-53
9614103-1	1998	Glucose-6-phosphate dehydrogenase (G6PDH) controls the flow of carbon through the pentose phosphate pathway and also produces NADPH needed for maintenance of reduced glutathione and reductive biosynthesis.	Pentosephosphates	82-99	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-33
9614103-1	1998	Glucose-6-phosphate dehydrogenase (G6PDH) controls the flow of carbon through the pentose phosphate pathway and also produces NADPH needed for maintenance of reduced glutathione and reductive biosynthesis.	Pentosephosphates	82-99	glucose-6-phosphate dehydrogenase	Rattus norvegicus	35-40
9924800-2	1998	The transketolase-catalysed reaction is part of the pentose phosphate pathway, where transketolase appears to control the non-oxidative branch of this pathway, although the overall flux of labelled substrates remains controversial.	Pentosephosphates	52-69	transketolase	Homo sapiens	4-17
9924800-2	1998	The transketolase-catalysed reaction is part of the pentose phosphate pathway, where transketolase appears to control the non-oxidative branch of this pathway, although the overall flux of labelled substrates remains controversial.	Pentosephosphates	52-69	transketolase	Homo sapiens	85-98
8910528-2	1996	Here we report that these two sod1Delta phenotypes were specifically suppressed by elevated expression of the TKL1 gene, encoding transketolase of the pentose phosphate pathway.	Pentosephosphates	151-168	transketolase TKL1	Saccharomyces cerevisiae S288C	110-114
9530133-5	1998	Xylitol mimicked the effects of glucose on FAS and ME expression, suggesting that an intermediate of the pentose phosphate pathway may be involved in mediating this response.	Pentosephosphates	105-122	fatty acid synthase	Gallus gallus	43-46
9339383-1	1997	Transaldolase (TAL) is a key enzyme of the pentose phosphate pathway, which is responsible for generation of reducing equivalents to protect cellular integrity from reactive oxygen intermediates.	Pentosephosphates	43-60	transaldolase 1	Homo sapiens	0-13
9339383-1	1997	Transaldolase (TAL) is a key enzyme of the pentose phosphate pathway, which is responsible for generation of reducing equivalents to protect cellular integrity from reactive oxygen intermediates.	Pentosephosphates	43-60	transaldolase 1	Homo sapiens	15-18
9380765-9	1997	These findings suggest that the reduction of ACCase is needed for activation of the enzyme, and a redox potential generated by photosynthesis is involved in its activation through thioredoxin as for enzymes of the reductive pentose phosphate cycle.	Pentosephosphates	224-241	thioredoxin	Homo sapiens	180-191
9005967-5	1997	In explants of glomeruli from control animals, increasing the glucose concentration in vitro from 5.6 mmol/L to 25 mmol/L resulted in a significant increase in the flux of glucose through the pentose phosphate pathway ([PPP] 1.29 +/- 0.08 v 2.00 +/- 0.11 nmol/h), de novo diacylglycerol synthesis (2.2 +/- 0.1 v 3.1 +/- 0.2 micromol/mg protein), membrane protein kinase C (PKC) activity (18.7 +/- 0.5 v 24.3 +/- 0.75 pmol/microg protein), and in vitro phospholipase A2 (PLA2) activity (2.18 +/- 0.46 v 3.83 +/- 1.07 nmol arachidonic acid hydrolyzed/min/mg cytosolic protein).	Pentosephosphates	192-209	phospholipase A2 group IB	Rattus norvegicus	452-468
9005967-5	1997	In explants of glomeruli from control animals, increasing the glucose concentration in vitro from 5.6 mmol/L to 25 mmol/L resulted in a significant increase in the flux of glucose through the pentose phosphate pathway ([PPP] 1.29 +/- 0.08 v 2.00 +/- 0.11 nmol/h), de novo diacylglycerol synthesis (2.2 +/- 0.1 v 3.1 +/- 0.2 micromol/mg protein), membrane protein kinase C (PKC) activity (18.7 +/- 0.5 v 24.3 +/- 0.75 pmol/microg protein), and in vitro phospholipase A2 (PLA2) activity (2.18 +/- 0.46 v 3.83 +/- 1.07 nmol arachidonic acid hydrolyzed/min/mg cytosolic protein).	Pentosephosphates	192-209	phospholipase A2 group IB	Rattus norvegicus	470-474
8955144-1	1996	Transaldolase (TAL) is a key enzyme of the reversible nonoxidative branch of the pentose phosphate pathway (PPP) that is responsible for the generation of NADPH to maintain glutathione at a reduced state (GSH) and, thus, to protect cellular integrity from reactive oxygen intermediates (ROIs).	Pentosephosphates	81-98	transaldolase 1	Homo sapiens	15-18
9219438-9	1996	The interplay between NADP+ and NADPH leading to enzyme activation or inhibition according to their relative or absolute concentrations as well as the control of enzyme activity by the adenine nucleotide system may contribute a refined mechanism for the regulation of glucose-6-phosphate dehydrogenase and therefore the pentose phosphate pathway in brain.	Pentosephosphates	320-337	glucose-6-phosphate dehydrogenase	Rattus norvegicus	268-301
9553122-2	1998	The principal intracellular reductant is NADPH, which is mainly produced by the pentose phosphate pathway through the actions of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, and by 6-phosphogluconate dehydrogenase.	Pentosephosphates	80-97	glucose-6-phosphate dehydrogenase	Homo sapiens	129-162
9553122-2	1998	The principal intracellular reductant is NADPH, which is mainly produced by the pentose phosphate pathway through the actions of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, and by 6-phosphogluconate dehydrogenase.	Pentosephosphates	80-97	glucose-6-phosphate dehydrogenase	Homo sapiens	164-168
9553122-2	1998	The principal intracellular reductant is NADPH, which is mainly produced by the pentose phosphate pathway through the actions of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, and by 6-phosphogluconate dehydrogenase.	Pentosephosphates	203-220	glucose-6-phosphate dehydrogenase	Homo sapiens	129-162
9553122-2	1998	The principal intracellular reductant is NADPH, which is mainly produced by the pentose phosphate pathway through the actions of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, and by 6-phosphogluconate dehydrogenase.	Pentosephosphates	203-220	glucose-6-phosphate dehydrogenase	Homo sapiens	164-168
9417069-0	1998	Carbon flux via the pentose phosphate pathway regulates the hepatic expression of the glucose-6-phosphatase and phosphoenolpyruvate carboxykinase genes in conscious rats.	Pentosephosphates	20-37	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	86-107
10214469-6	1998	In RBC formed from leukaemic cell clone (PV, CML), a simultaneous significant increase in G6PD and GSSG-R activities was found, which indicated activisation of pentose phosphate pathways (PPP) in these pathologies; in anaemia they function less effectively.	Pentosephosphates	160-177	glucose-6-phosphate dehydrogenase	Homo sapiens	90-94
9477574-10	1998	Glucose 6-phosphate imported via the GPT can thus be used either for starch biosynthesis, during which process inorganic phosphate is released, or as a substrate for the oxidative pentose phosphate pathway, yielding triose phosphates.	Pentosephosphates	180-197	glucose-6-phosphate/phosphate-translocator precursor	Zea mays	37-40
9405168-6	1997	The specific activities of the myocardial pentose phosphate pathway enzymes glucose-6-phosphate-dehydrogenase (G-6-PD) and 6-phosphogluconate-dehydrogenase (6-PGD) were determined using a spectrophotometric assay.	Pentosephosphates	42-59	glucose-6-phosphate dehydrogenase	Rattus norvegicus	76-109
9405168-6	1997	The specific activities of the myocardial pentose phosphate pathway enzymes glucose-6-phosphate-dehydrogenase (G-6-PD) and 6-phosphogluconate-dehydrogenase (6-PGD) were determined using a spectrophotometric assay.	Pentosephosphates	42-59	glucose-6-phosphate dehydrogenase	Rattus norvegicus	111-117
9175113-1	1997	The aim of this study was to determine whether neural cells exposed to beta amyloid (A beta) activate the pentose phosphate pathway (PPP), a critical oxidative stress defense mechanism.	Pentosephosphates	106-123	amyloid beta precursor protein	Homo sapiens	85-91
8910528-7	1996	Our studies suggest that this defect results from the impaired redox status of aerobically grown sod1 and zwf1 mutants, implicating Sod1 and the pentose phosphate pathway as being critical for maintenance of the cellular redox state.	Pentosephosphates	145-162	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	97-101
8910528-7	1996	Our studies suggest that this defect results from the impaired redox status of aerobically grown sod1 and zwf1 mutants, implicating Sod1 and the pentose phosphate pathway as being critical for maintenance of the cellular redox state.	Pentosephosphates	145-162	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	106-110
8910528-5	1996	We determined that a functional ZWF1 gene product was required for TKL1 to suppress sod1Delta, leading us to propose that increased flux through the oxidative reactions of the pentose phosphate pathway can rescue sod1 methionine auxotrophy.	Pentosephosphates	176-193	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	32-36
8910528-5	1996	We determined that a functional ZWF1 gene product was required for TKL1 to suppress sod1Delta, leading us to propose that increased flux through the oxidative reactions of the pentose phosphate pathway can rescue sod1 methionine auxotrophy.	Pentosephosphates	176-193	transketolase TKL1	Saccharomyces cerevisiae S288C	67-71
8910528-5	1996	We determined that a functional ZWF1 gene product was required for TKL1 to suppress sod1Delta, leading us to propose that increased flux through the oxidative reactions of the pentose phosphate pathway can rescue sod1 methionine auxotrophy.	Pentosephosphates	176-193	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	84-88
8760336-1	1996	We review here some recent data about glucose-6-phosphate dehydrogenase (G6PD), the first and key regulatory enzyme of the pentose phosphate pathway.	Pentosephosphates	123-140	glucose-6-phosphate dehydrogenase	Homo sapiens	38-71
8879247-11	1996	We have characterized RPE1 by testing enzyme activities in rpe1 deletion mutants and in strains that overexpress RPE1, and compared the hydrogen peroxide sensitivity of rpe1 mutants to that of other mutants in the pentose phosphate pathway.	Pentosephosphates	214-231	ribulose-phosphate 3-epimerase RPE1	Saccharomyces cerevisiae S288C	22-26
8760336-1	1996	We review here some recent data about glucose-6-phosphate dehydrogenase (G6PD), the first and key regulatory enzyme of the pentose phosphate pathway.	Pentosephosphates	123-140	glucose-6-phosphate dehydrogenase	Homo sapiens	73-77
21153090-6	1996	On the basis of its amino acid sequence, P36 could be related to transaldolase, an enzyme of the pentose phosphate pathway which generates NADPH.	Pentosephosphates	97-114	annexin A2	Homo sapiens	41-44
21153090-6	1996	On the basis of its amino acid sequence, P36 could be related to transaldolase, an enzyme of the pentose phosphate pathway which generates NADPH.	Pentosephosphates	97-114	transaldolase 1	Homo sapiens	65-78
8549753-5	1995	In contrast, transketolase, a sequential enzyme of epimerase in the reductive and oxidative pentose phosphate cycle, is accumulated in all plant tissues.	Pentosephosphates	92-109	transketolase, chloroplastic	Solanum tuberosum	13-26
8549825-1	1996	Transaldolase is a key enzyme of the pentose phosphate pathway.	Pentosephosphates	37-54	transaldolase 1	Homo sapiens	0-13
8534086-4	1995	In order to increase the flux through the pentose phosphate pathway, the S. cerevisiae TKL1 and TAL1 genes encoding transketolase and transaldolase were overexpressed.	Pentosephosphates	42-59	transketolase TKL1	Saccharomyces cerevisiae S288C	87-91
8534086-4	1995	In order to increase the flux through the pentose phosphate pathway, the S. cerevisiae TKL1 and TAL1 genes encoding transketolase and transaldolase were overexpressed.	Pentosephosphates	42-59	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1	Saccharomyces cerevisiae S288C	96-100
8573290-5	1995	In vitro experiments with [1-14C]glucose and [U-14C]glucose have shown that Lmox/Lox-loaded RBCs counteract the production of H2O2 by increasing the amount of glucose metabolized in the pentose phosphate pathway.	Pentosephosphates	186-203	lysyl oxidase	Mus musculus	81-84
7489710-2	1995	It has important functions in intermediary metabolism because it catalyzes the first step in the pentose phosphate pathway and provides reductive potential in the form of NADPH.	Pentosephosphates	97-114	2,4-dienoyl-CoA reductase 1	Homo sapiens	171-176
7565637-8	1995	The additional glucose imported by astrocytes on exposure to TNF-alpha and IL-1 alpha is neither stored as glycogen nor released as glycolytically derived lactate, suggesting that it is processed through the tricarboxylic acid cycle or pentose phosphate pathway.	Pentosephosphates	236-253	tumor necrosis factor	Mus musculus	61-70
7654215-2	1995	Adrenaline has recently been shown to stimulate both glucose metabolism and H2O2 release by macrophages but the activity of the key pentose phosphate pathway enzyme, glucose-6-phosphate dehydrogenase (which generates the NADPH crucial for the reduction of molecular oxygen), was reduced under these conditions [Costa Rosa, Safi, Cury and Curi (1992) Biochem.	Pentosephosphates	132-149	glucose-6-phosphate dehydrogenase	Homo sapiens	166-199
7565637-8	1995	The additional glucose imported by astrocytes on exposure to TNF-alpha and IL-1 alpha is neither stored as glycogen nor released as glycolytically derived lactate, suggesting that it is processed through the tricarboxylic acid cycle or pentose phosphate pathway.	Pentosephosphates	236-253	interleukin 1 alpha	Mus musculus	75-85
7477671-3	1995	FBP had little effect on CO2 production by glycolysis, but increased CO2 production by the pentose phosphate pathway.	Pentosephosphates	91-108	fructose-bisphosphatase 1	Homo sapiens	0-3
7998349-4	1994	Activity of catalase, glutathione reductase and dehydrogenases of the pentosephosphate way were not normalized during ferrocene protection from sodium nitrite intoxication.	Pentosephosphates	70-86	catalase	Homo sapiens	12-20
21559706-1	1994	Abundance of messenger RNA (mRNA) and activity of glucose-6-phosphate dehydrogenase (G6PDH), the rate limiting enzyme of the oxidative pentose phosphate pathway, were studied in preneoplastic foci of altered hepatocytes (FAH) and hepatocellular carcinomas (HCC) induced in rats by limited oral exposure to N-nitrosomorpholine (NNM-stop model).	Pentosephosphates	135-152	glucose-6-phosphate dehydrogenase	Rattus norvegicus	50-83
21559706-1	1994	Abundance of messenger RNA (mRNA) and activity of glucose-6-phosphate dehydrogenase (G6PDH), the rate limiting enzyme of the oxidative pentose phosphate pathway, were studied in preneoplastic foci of altered hepatocytes (FAH) and hepatocellular carcinomas (HCC) induced in rats by limited oral exposure to N-nitrosomorpholine (NNM-stop model).	Pentosephosphates	135-152	glucose-6-phosphate dehydrogenase	Rattus norvegicus	85-90
7964452-3	1994	TAL-H is a key enzyme of the nonoxidative pentose phosphate pathway (PPP) providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis.	Pentosephosphates	42-59	transaldolase 1	Homo sapiens	0-5
8524613-1	1995	Seasonal changes in the circadian activity of the cyclic nucleotides and of the key enzyme of the pentosephosphate cycle (G-6-PD) in the peripheral blood of golden hamsters].	Pentosephosphates	98-114	glucose-6-phosphate 1-dehydrogenase	Mesocricetus auratus	122-128
7605896-15	1995	In intact rats, norepinephrine elicited an increase in the mRNA and activity of glucose-6-phosphate dehydrogenase, the first and regulating enzyme of the oxidative pentose phosphate pathway, in a time-dependent manner.	Pentosephosphates	164-181	glucose-6-phosphate dehydrogenase	Rattus norvegicus	80-113
12232264-2	1994	The onset of photosynthetic NO3- assimilation in N-limited Chlamydomonas reinhardtii increased the initial extractable activity of the glucose-6-phosphate dehydrogenase (G6PDH), the key regulatory step of the oxidative pentose phosphate pathway.	Pentosephosphates	219-236	uncharacterized protein	Chlamydomonas reinhardtii	135-168
12232264-2	1994	The onset of photosynthetic NO3- assimilation in N-limited Chlamydomonas reinhardtii increased the initial extractable activity of the glucose-6-phosphate dehydrogenase (G6PDH), the key regulatory step of the oxidative pentose phosphate pathway.	Pentosephosphates	219-236	uncharacterized protein	Chlamydomonas reinhardtii	170-175
8031146-10	1994	Cells depleted of catalase alone had a profile of survival and pentose phosphate cycle activity similar to that of control cells when exposed to hydrogen peroxide.	Pentosephosphates	63-80	catalase	Cricetulus griseus	18-26
8031146-16	1994	The data suggest that the ability of catalase to metabolise peroxide may also depend on metabolism of glucose via the pentose phosphate cycle.	Pentosephosphates	118-135	catalase	Cricetulus griseus	37-45
7998349-4	1994	Activity of catalase, glutathione reductase and dehydrogenases of the pentosephosphate way were not normalized during ferrocene protection from sodium nitrite intoxication.	Pentosephosphates	70-86	glutathione-disulfide reductase	Homo sapiens	22-43
7998349-5	1994	In case of ferrocene protection the catalase activity during sodium nitrite intoxication remains lowered, while activity of glutathione reductase and dehydrogenases of the pentosephosphate pathway grows sharply.	Pentosephosphates	172-188	glutathione-disulfide reductase	Homo sapiens	124-145
7901008-6	1993	It is proposed that the growth defect of pgi1 deletion mutants on glucose is due to a rapid depletion of NADP which is needed as a cofactor in the oxidative reactions of the pentose phosphate pathway.	Pentosephosphates	174-191	glucose-6-phosphate isomerase	Saccharomyces cerevisiae S288C	41-45
8299150-10	1993	This suggests the existence of an alternative but limited source of pentose phosphates and erythrose 4-phosphate in the tkl1 zwf1 double mutants.	Pentosephosphates	68-86	transketolase TKL1	Saccharomyces cerevisiae S288C	120-124
8299150-10	1993	This suggests the existence of an alternative but limited source of pentose phosphates and erythrose 4-phosphate in the tkl1 zwf1 double mutants.	Pentosephosphates	68-86	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	125-129
8119488-1	1994	The enzyme, glucose-6-phosphate dehydrogenase (G6PDH, EC1.1.1.49), has long been considered and studied as the archetypical X-linked "housekeeping" enzyme that is present in all cells, where it plays the key role in regulating carbon flow through the pentose phosphate pathway.	Pentosephosphates	251-268	glucose-6-phosphate dehydrogenase	Homo sapiens	12-45
8119488-1	1994	The enzyme, glucose-6-phosphate dehydrogenase (G6PDH, EC1.1.1.49), has long been considered and studied as the archetypical X-linked "housekeeping" enzyme that is present in all cells, where it plays the key role in regulating carbon flow through the pentose phosphate pathway.	Pentosephosphates	251-268	glucose-6-phosphate dehydrogenase	Homo sapiens	47-52
7768213-1	1994	We propose that monitoring the activity of the pentose phosphate pathway (PPP) may provide an opportunity to obtain unique information regarding the metabolic response to oxidative stress since glutathione peroxidase activity is coupled, via glutathione reductase, to the PPP enzyme glucose-6-phosphate dehydrogenase.	Pentosephosphates	47-64	glutathione-disulfide reductase	Rattus norvegicus	242-263
7768213-1	1994	We propose that monitoring the activity of the pentose phosphate pathway (PPP) may provide an opportunity to obtain unique information regarding the metabolic response to oxidative stress since glutathione peroxidase activity is coupled, via glutathione reductase, to the PPP enzyme glucose-6-phosphate dehydrogenase.	Pentosephosphates	47-64	glucose-6-phosphate dehydrogenase	Rattus norvegicus	283-316
1463749-0	1992	High control coefficient of transketolase in the nonoxidative pentose phosphate pathway of human erythrocytes: NMR, antibody, and computer simulation studies.	Pentosephosphates	62-79	transketolase	Homo sapiens	28-41
7681896-13	1993	It also attenuated markedly the norepinephrine (NE)-induced increase in the activity of cardiac glucose-6-phosphate dehydrogenase (G-6-PD), the first and rate-limiting enzyme of the oxidative pentose phosphate pathway (PPP), although a 37% stimulation persisted.	Pentosephosphates	192-209	glucose-6-phosphate dehydrogenase	Rattus norvegicus	96-129
7681896-13	1993	It also attenuated markedly the norepinephrine (NE)-induced increase in the activity of cardiac glucose-6-phosphate dehydrogenase (G-6-PD), the first and rate-limiting enzyme of the oxidative pentose phosphate pathway (PPP), although a 37% stimulation persisted.	Pentosephosphates	192-209	glucose-6-phosphate dehydrogenase	Rattus norvegicus	131-137
7903264-5	1993	Somatostatin-14 injection also resulted in reduced hepatic glucose-6-phosphate dehydrogenase activity, which may indicate a decrease in glucose channeling through the pentose phosphate shunt.	Pentosephosphates	167-184	glucose-6-phosphate-1-dehydrogenase	Oncorhynchus mykiss	59-92
8357848-6	1993	Our evidence from experiments with [1-13C]-, [2-13C]-, and [3-13C]D-glucoses indicates that there is an observable reverse flux of fructose 6-phosphate through the reactions catalyzed by transketolase and transaldolase, even in the presence of a net flux through the pentose phosphate pathway.	Pentosephosphates	267-284	transketolase	Homo sapiens	187-200
8357848-6	1993	Our evidence from experiments with [1-13C]-, [2-13C]-, and [3-13C]D-glucoses indicates that there is an observable reverse flux of fructose 6-phosphate through the reactions catalyzed by transketolase and transaldolase, even in the presence of a net flux through the pentose phosphate pathway.	Pentosephosphates	267-284	transaldolase 1	Homo sapiens	205-218
8439396-2	1993	Rapid ferrihemoglobin formation mediated by the NADPH-dependent enzymic cycling of the nitrosoarene ("Kiese cycle") and extensive GSSG production caused an immediate drain of G-6-P into the pentose phosphate pathway at maximal flow.	Pentosephosphates	190-207	2,4-dienoyl-CoA reductase 1	Homo sapiens	48-53
1463749-1	1992	The degree of control exerted by transketolase over metabolite flux in the nonoxidative pentose phosphate pathway in human erythrocytes was investigated using transketolase antiserum to modulate the activity of that enzyme.	Pentosephosphates	88-105	transketolase	Homo sapiens	33-46
1471978-2	1992	Sheep liver 6-phosphogluconate dehydrogenase (6-PGDH) is an enzyme of the pentose phosphate pathway.	Pentosephosphates	74-91	6-phosphogluconate dehydrogenase, decarboxylating	Ovis aries	12-44
1471978-2	1992	Sheep liver 6-phosphogluconate dehydrogenase (6-PGDH) is an enzyme of the pentose phosphate pathway.	Pentosephosphates	74-91	6-phosphogluconate dehydrogenase, decarboxylating	Ovis aries	46-52
1384463-1	1992	The capacity of the oxidative pentose phosphate pathway (PPP) in the heart is small, since the activity of glucose-6-phosphate dehydrogenase (G-6-PD), the first and rate-limiting enzyme, is very low.	Pentosephosphates	30-47	glucose-6-phosphate dehydrogenase	Rattus norvegicus	142-148
1328471-1	1992	Growth of Saccharomyces cerevisiae on D-glucono-delta-lactone (delta gl) was found to be associated with a specific coordinate induction of the synthesis of two enzymes of the oxidative pentose phosphate pathway--6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase--together with that of a third enzyme, gluconokinase.	Pentosephosphates	186-203	gluconokinase	Saccharomyces cerevisiae S288C	315-328
1360622-4	1992	Glucose-6-phosphate dehydrogenase (G6PDH), which is the first enzyme in the pentose phosphate pathway, shunting glucose towards nucleic acid synthesis, was more than 300% higher in gliomas compared with the normal cortex.	Pentosephosphates	76-93	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-33
1360622-4	1992	Glucose-6-phosphate dehydrogenase (G6PDH), which is the first enzyme in the pentose phosphate pathway, shunting glucose towards nucleic acid synthesis, was more than 300% higher in gliomas compared with the normal cortex.	Pentosephosphates	76-93	glucose-6-phosphate dehydrogenase	Rattus norvegicus	35-40
1384463-1	1992	The capacity of the oxidative pentose phosphate pathway (PPP) in the heart is small, since the activity of glucose-6-phosphate dehydrogenase (G-6-PD), the first and rate-limiting enzyme, is very low.	Pentosephosphates	30-47	glucose-6-phosphate dehydrogenase	Rattus norvegicus	107-140
11538180-3	1992	Endosperm extracts contained the enzymes necessary to reduce NADP by the oxidative pentose phosphate pathway (hexokinase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase).	Pentosephosphates	83-100	hexokinase-6	Triticum aestivum	110-120
11538180-3	1992	Endosperm extracts contained the enzymes necessary to reduce NADP by the oxidative pentose phosphate pathway (hexokinase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase).	Pentosephosphates	83-100	glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform	Triticum aestivum	122-155
11538180-5	1992	The results suggest that thioredoxin, reduced by NADPH generated via the oxidative pentose phosphate pathway, functions as a signal in germination to enhance metabolic processes such as the mobilization of storage proteins and, as found earlier, the activation of enzymes.	Pentosephosphates	83-100	thioredoxin H4-2	Triticum aestivum	25-36
1790318-7	1991	The activity of glucose-6-phosphate dehydrogenase together with a higher [1-14C]glucose/[U-14C]glucose descarboxylation ratio indicate a predominant very active pentose phosphate pathway which may be responsible for the enhanced glucose uptake observed in the hepatocytes from the obese animals.	Pentosephosphates	161-178	glucose-6-phosphate dehydrogenase	Rattus norvegicus	16-49
1337642-5	1992	In addition, since NADPH concentrations influence the concentration of reduced glutathione, we studied glucose-6-phosphate dehydrogenase activity as an indicator of pentose phosphate shunt activity, the main source of NADPH.	Pentosephosphates	165-182	glucose-6-phosphate dehydrogenase	Homo sapiens	103-136
1579154-5	1992	Also, the activities of some fundamental enzymes of the oxidative pentose phosphate pathway i.e. glucose-6-phosphate dehydrogenase (G-6-PD) and 6-phospho-gluconate dehydrogenase (6-PGD) in cytoplasmic and mitochondrial fractions of the same organs were markedly increased.	Pentosephosphates	66-83	glucose-6-phosphate dehydrogenase	Rattus norvegicus	97-130
1579154-5	1992	Also, the activities of some fundamental enzymes of the oxidative pentose phosphate pathway i.e. glucose-6-phosphate dehydrogenase (G-6-PD) and 6-phospho-gluconate dehydrogenase (6-PGD) in cytoplasmic and mitochondrial fractions of the same organs were markedly increased.	Pentosephosphates	66-83	glucose-6-phosphate dehydrogenase	Rattus norvegicus	132-138
1309399-2	1992	The activity of transaldolase in the pentose phosphate pathway was also measured.	Pentosephosphates	37-54	transaldolase 1	Rattus norvegicus	16-29
1651223-3	1991	Dehydroepiandrosterone (DHEA) is a normally occurring adrenal androgen that inhibits glucose-6-phosphate dehydrogenase, the initial enzyme in the pentose phosphate shunt necessary for NADPH generation and superoxide anion formation.	Pentosephosphates	146-163	glucose-6-phosphate dehydrogenase	Homo sapiens	85-118
1764500-3	1991	High activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase were found in lung tissue, suggesting the importance of the pentose phosphate pathway in the lung.	Pentosephosphates	150-167	glucose-6-phosphate dehydrogenase	Rattus norvegicus	19-52
2043108-5	1991	Two of the enzymes within the pentose phosphate pathway reveal a distant similarity of interest for further evaluation, between a C-terminal 178-residue segment of glucose-6-phosphate dehydrogenase and the N-terminal part of 6-phosphogluconate dehydrogenase.	Pentosephosphates	30-47	glucose-6-phosphate dehydrogenase	Homo sapiens	164-197
2011653-9	1991	Other findings of our investigations point to a positive correlation between the activity of GPDH and PGDH on the one hand and that of the non-oxidative enzymes of the pentose phosphate pathway, the enzymes TA, TK, RPI and RPE on the other hand.	Pentosephosphates	168-185	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	102-106
1907131-6	1991	Females of the mex1 mutant strain show statistically significant elevated levels of the pentose phosphate shunt enzymes, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase.	Pentosephosphates	88-105	midgut expression 1	Drosophila melanogaster	15-19
1703936-1	1990	There have been several reports concerning elevated glucose 6 phosphate dehydrogenase (G6PDH), the rate-limiting enzyme of pentose phosphate pathway (PPP), in experimental muscle disturbances.	Pentosephosphates	123-140	glucose-6-phosphate dehydrogenase	Homo sapiens	52-85
2174429-0	1990	Epidermal growth factor and 12-O-tetradecanoylphorbol 13-acetate stimulate lactate production and the pentose phosphate pathway in freshly isolated rat hepatocytes.	Pentosephosphates	102-119	epidermal growth factor like 1	Rattus norvegicus	0-23
2174429-8	1990	We conclude that EGF stimulates glycolysis and the pentose phosphate pathway in isolated hepatocytes from fed rats.	Pentosephosphates	51-68	epidermal growth factor like 1	Rattus norvegicus	17-20
1978808-1	1990	The oxidative pentose phosphate pathway is poorly developed in the rat heart compared with other organs, since the activity of glucose-6-phosphate dehydrogenase (G-6-PDH), the first and rate-limiting enzyme of the oxidative pentose phosphate pathway, is low.	Pentosephosphates	14-31	glucose-6-phosphate dehydrogenase	Rattus norvegicus	127-160
1978808-1	1990	The oxidative pentose phosphate pathway is poorly developed in the rat heart compared with other organs, since the activity of glucose-6-phosphate dehydrogenase (G-6-PDH), the first and rate-limiting enzyme of the oxidative pentose phosphate pathway, is low.	Pentosephosphates	14-31	glucose-6-phosphate dehydrogenase	Rattus norvegicus	162-169
1978808-1	1990	The oxidative pentose phosphate pathway is poorly developed in the rat heart compared with other organs, since the activity of glucose-6-phosphate dehydrogenase (G-6-PDH), the first and rate-limiting enzyme of the oxidative pentose phosphate pathway, is low.	Pentosephosphates	224-241	glucose-6-phosphate dehydrogenase	Rattus norvegicus	127-160
1978808-1	1990	The oxidative pentose phosphate pathway is poorly developed in the rat heart compared with other organs, since the activity of glucose-6-phosphate dehydrogenase (G-6-PDH), the first and rate-limiting enzyme of the oxidative pentose phosphate pathway, is low.	Pentosephosphates	224-241	glucose-6-phosphate dehydrogenase	Rattus norvegicus	162-169
2176137-9	1990	The pentose phosphate pathway enzymes G6PDH and 6PGDH showed the most remarkable changes in livers treated with lead nitrate.	Pentosephosphates	4-21	glucose-6-phosphate dehydrogenase	Rattus norvegicus	38-43
16667826-1	1990	Based on localization and high activities of pyrroline-5-carboxylate reductase and proline dehydrogenase activities in soybean nodules, we previously suggested two major roles for pyrroline-5-carboxylate reductase in addition to the production of the considerable quantity of proline needed for biosynthesis; namely, transfer of energy to the location of biological N(2) fixation, and production of NADP(+) to drive the pentose phosphate pathway.	Pentosephosphates	420-437	pyrroline-5-carboxylate reductase	Glycine max	45-78
16667826-1	1990	Based on localization and high activities of pyrroline-5-carboxylate reductase and proline dehydrogenase activities in soybean nodules, we previously suggested two major roles for pyrroline-5-carboxylate reductase in addition to the production of the considerable quantity of proline needed for biosynthesis; namely, transfer of energy to the location of biological N(2) fixation, and production of NADP(+) to drive the pentose phosphate pathway.	Pentosephosphates	420-437	proline dehydrogenase	Glycine max	83-104
16667826-1	1990	Based on localization and high activities of pyrroline-5-carboxylate reductase and proline dehydrogenase activities in soybean nodules, we previously suggested two major roles for pyrroline-5-carboxylate reductase in addition to the production of the considerable quantity of proline needed for biosynthesis; namely, transfer of energy to the location of biological N(2) fixation, and production of NADP(+) to drive the pentose phosphate pathway.	Pentosephosphates	420-437	pyrroline-5-carboxylate reductase	Glycine max	180-213
1703936-1	1990	There have been several reports concerning elevated glucose 6 phosphate dehydrogenase (G6PDH), the rate-limiting enzyme of pentose phosphate pathway (PPP), in experimental muscle disturbances.	Pentosephosphates	123-140	glucose-6-phosphate dehydrogenase	Homo sapiens	87-92
2405838-14	1990	The dual activation of these serial processes coupled to the loss of the reaction products of the pentose phosphate-shunt pathway from the cells in the form of reactive oxygen intermediates, protons and CO2 could explain the synergistic action of phorbol and mCSF-1 in activation of sugar transport in macrophages.	Pentosephosphates	98-115	colony stimulating factor 1 (macrophage)	Mus musculus	259-265
16667598-10	1990	The results suggest that the enzyme is similar to ferredoxin-NADP(+) oxidoreductase from chloroplasts and cyanobacteria and is the key enzyme catalyzing the electron transport between NADPH, generated by the pentose phosphate pathway, and ferredoxin in plastids of plant heterotrophic tissues.	Pentosephosphates	208-225	2,4-dienoyl-CoA reductase 1	Homo sapiens	184-189
32859923-4	2020	In our system HK2 is the greatest ATP consumer, indicating energy failure may not be a general deficiency in producing ATP, but rather failure to recoup the ATP cost of glycolysis and diversion of glucose metabolites to the pentose phosphate pathway.	Pentosephosphates	224-241	hexokinase 2	Homo sapiens	14-17
2127149-5	1990	Our findings suggest that in mouse spermatozoa, the enhanced glutathione reductase and peroxidase activities induced by the spontaneous lipid peroxidation increases NADPH production from the pentose phosphate shunt, while in rabbit spermatozoa, NADPH production is much lower.	Pentosephosphates	191-208	glutathione reductase	Mus musculus	61-82
2377032-1	1990	Glucose-6-phosphate dehydrogenase (G-6-PD) is the first enzyme of the pentose phosphate pathway and has been extensively investigated.	Pentosephosphates	70-87	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
2377032-1	1990	Glucose-6-phosphate dehydrogenase (G-6-PD) is the first enzyme of the pentose phosphate pathway and has been extensively investigated.	Pentosephosphates	70-87	glucose-6-phosphate dehydrogenase	Homo sapiens	35-41
33800095-6	2021	Previous analyses have identified enzymes of the oxidative pentose phosphate pathway to be inactivated by reduction through thioredoxins.	Pentosephosphates	59-76	thioredoxin	Homo sapiens	124-136
2241998-2	1990	A significant decrease in the activity of glutathione peroxidase and an increase in the glutathione reductase activity were found with increase in the time of diabetes which may result in the alteration in the activity of the pentose phosphate pathway by the modulation of the levels of NADPH.	Pentosephosphates	226-243	glutathione-disulfide reductase	Rattus norvegicus	88-109
2296762-2	1990	We have also compared the activities of ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis, and glucose-6-phosphate dehydrogenase (G6PD), the key enzyme of the pentose phosphate cycle and a typical marker of oxidant injury, to assess whether ODC can serve as a sensitive marker of O3 effects on the lung.	Pentosephosphates	191-208	glucose-6-phosphate dehydrogenase	Rattus norvegicus	127-160
2296762-2	1990	We have also compared the activities of ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis, and glucose-6-phosphate dehydrogenase (G6PD), the key enzyme of the pentose phosphate cycle and a typical marker of oxidant injury, to assess whether ODC can serve as a sensitive marker of O3 effects on the lung.	Pentosephosphates	191-208	glucose-6-phosphate dehydrogenase	Rattus norvegicus	162-166
34662447-8	2022	Bioinformatic integration revealed a significant shunting of glucose away from glycolysis-citrate cycle and glycerol-lipid genesis to pentose phosphate cycle for NADPH/GSH/GSSG redox and pentose moieties for purine and pyrimidine nucleotides, and glycosylation/glucuronidation.	Pentosephosphates	134-151	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	162-167
34801666-6	2022	Mechanistically, NO increased S-nitrosylation of pyruvate kinase M2 (PKM2) and inhibited its activity, which thus diverted glucose metabolic flux from glycolysis into the pentose phosphate pathway to increase production of reducing equivalents (NADPH and GSH) and eventually prevented H2O2-induced oxidative damage.	Pentosephosphates	171-188	pyruvate kinase M1/2	Homo sapiens	49-67
34801666-6	2022	Mechanistically, NO increased S-nitrosylation of pyruvate kinase M2 (PKM2) and inhibited its activity, which thus diverted glucose metabolic flux from glycolysis into the pentose phosphate pathway to increase production of reducing equivalents (NADPH and GSH) and eventually prevented H2O2-induced oxidative damage.	Pentosephosphates	171-188	pyruvate kinase M1/2	Homo sapiens	69-73
34740864-4	2022	GM-CSF also regulated cytosolic pathways including glycolysis, pentose phosphate pathway, and amino acid synthesis.	Pentosephosphates	63-80	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	0-6
33235622-7	2021	In the pathway analysis, the two most significantly enriched pathways were the TGF-beta signaling pathway for upregulated mRNAs and the pentose phosphate pathway for downregulated mRNAs.	Pentosephosphates	136-153	transforming growth factor alpha	Homo sapiens	79-87
34936958-9	2022	The metabolomics analyses have shown that in the group with higher drip loss from muscle tissue the increase of metabolism of energy transformations taking place in muscle tissue after slaughter was observed and that differences between groups are related to 11 metabolic pathways, mainly carbohydrate metabolism (glycolysis, gluconeogenesis, pentose phosphate pathway) adenine and adenosine salvage, adenosine nucleotides degradation, arsenate detoxification, methylglyoxal degradation.	Pentosephosphates	343-360	DL	Gallus gallus	67-76
34779552-6	2022	The pep-AP/TALDO1 pathway attenuates the pentose phosphate pathway (PPP), reducing NADPH/NADP+ and glutathione (GSH) levels and causing ROS accumulation and apoptosis, which sensitizes CRC cells to L-OHP in vitro and in vivo.	Pentosephosphates	41-58	transaldolase 1	Homo sapiens	11-17
34944532-0	2021	Metformin Treatment or PRODH/POX-Knock out Similarly Induces Apoptosis by Reprograming of Amino Acid Metabolism, TCA, Urea Cycle and Pentose Phosphate Pathway in MCF-7 Breast Cancer Cells.	Pentosephosphates	133-150	proline dehydrogenase 1	Homo sapiens	23-28
34973363-8	2022	Glucose-6-phosphate dehydrogenase (G6PD), was known as a rate-limiting enzyme in the pentose phosphate pathway, however, the pharmacological inhibition of G6PD by 6-aminonicotinamide (6-AN), enhanced the shikonin-induced cytotoxicity but has no selectivity on KEAP1-mutant NSCLC cells.	Pentosephosphates	85-102	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
34973363-8	2022	Glucose-6-phosphate dehydrogenase (G6PD), was known as a rate-limiting enzyme in the pentose phosphate pathway, however, the pharmacological inhibition of G6PD by 6-aminonicotinamide (6-AN), enhanced the shikonin-induced cytotoxicity but has no selectivity on KEAP1-mutant NSCLC cells.	Pentosephosphates	85-102	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
34973363-8	2022	Glucose-6-phosphate dehydrogenase (G6PD), was known as a rate-limiting enzyme in the pentose phosphate pathway, however, the pharmacological inhibition of G6PD by 6-aminonicotinamide (6-AN), enhanced the shikonin-induced cytotoxicity but has no selectivity on KEAP1-mutant NSCLC cells.	Pentosephosphates	85-102	glucose-6-phosphate dehydrogenase	Homo sapiens	155-159
34922556-2	2021	TKTL1 is a key protein in glucose metabolism in cancer cells and controls the pentose phosphate pathway (PPP).	Pentosephosphates	78-95	transketolase like 1	Homo sapiens	0-5
34976860-3	2021	Phosphoglucose isomerase (PGI) catalyzes the reversible conversion between glucose-6-phosphate and fructose-6-phosphate, thus acting as a key node for glycolysis, pentose phosphate pathway, and cell wall biosynthesis in fungi.	Pentosephosphates	163-180	glucose-6-phosphate isomerase	Homo sapiens	26-29
34944532-0	2021	Metformin Treatment or PRODH/POX-Knock out Similarly Induces Apoptosis by Reprograming of Amino Acid Metabolism, TCA, Urea Cycle and Pentose Phosphate Pathway in MCF-7 Breast Cancer Cells.	Pentosephosphates	133-150	proline dehydrogenase 1	Homo sapiens	29-32
34857034-0	2021	Correction to: PFKFB4 is overexpressed in clear-cell renal cell carcinoma promoting pentose phosphate pathway that mediates Sunitinib resistance.	Pentosephosphates	84-101	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Homo sapiens	15-21
34343647-0	2021	Rhubarb granule promotes diethylnitrosamine-induced liver tumorigenesis by activating the oxidative branch of pentose phosphate pathway via G6PD in rats.	Pentosephosphates	110-127	glucose-6-phosphate dehydrogenase	Rattus norvegicus	140-144
34916824-12	2021	Metabolomics analysis showed that Dex activated the pentose phosphate pathway and increased glutathione in VECs via up-regulation of G6PD expression.	Pentosephosphates	52-69	glucose-6-phosphate dehydrogenase	Homo sapiens	133-137
34823997-7	2021	We generated Shpk knockout mouse models and detected a phenotype consisting of perturbations in the pentose phosphate pathway (PPP), the metabolic shunt regulated by SHPK.	Pentosephosphates	100-117	sedoheptulokinase	Mus musculus	13-17
34823997-7	2021	We generated Shpk knockout mouse models and detected a phenotype consisting of perturbations in the pentose phosphate pathway (PPP), the metabolic shunt regulated by SHPK.	Pentosephosphates	100-117	sedoheptulokinase	Mus musculus	166-170
34657129-0	2021	NeuroD1 promotes tumor cell proliferation and tumorigenesis by directly activating the pentose phosphate pathway in colorectal carcinoma.	Pentosephosphates	87-104	neuronal differentiation 1	Homo sapiens	0-7
34889054-5	2021	We found an upregulation of genes involved in the oxidative branch of the pentose phosphate pathways (PPP) and mitochondrial branch of the folate cycle suggesting an increase in the production of NADPH.	Pentosephosphates	74-91	2,4-dienoyl-CoA reductase 1	Homo sapiens	196-201
34845393-4	2021	Here we show using stable isotope tracing in mice that de novo lipogenesis in adipose is supported by glucose and its catabolism via the pentose phosphate pathway to make NADPH.	Pentosephosphates	137-154	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	171-176
34657129-3	2021	In this study, we report that NeuroD1 is positively correlated with glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway (PPP), in colorectal cancer cells.	Pentosephosphates	142-159	neuronal differentiation 1	Homo sapiens	30-37
34657129-3	2021	In this study, we report that NeuroD1 is positively correlated with glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway (PPP), in colorectal cancer cells.	Pentosephosphates	142-159	glucose-6-phosphate dehydrogenase	Homo sapiens	68-101
34657129-3	2021	In this study, we report that NeuroD1 is positively correlated with glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway (PPP), in colorectal cancer cells.	Pentosephosphates	142-159	glucose-6-phosphate dehydrogenase	Homo sapiens	103-107
34743684-6	2021	ELOVL6 and ELOVL7 are sensitive to ROS induced depletion of cellular NADPH and insufficient regeneration via the pentose phosphate pathway and mitochondrial fatty acid oxidation.	Pentosephosphates	113-130	ELOVL fatty acid elongase 6	Homo sapiens	0-6
34737211-5	2022	The upregulation of neomorphic mutant IDH1 by FBXW7 deletion stimulated production of the oncometabolite 2-hydroxyglutarate (2-HG) at the expense of increasing pentose phosphate pathway (PPP) activity and NADPH consumption, limiting the buffering ability against radiation-induced oxidative stress.	Pentosephosphates	160-177	F-box and WD repeat domain containing 7	Homo sapiens	46-51
34476741-2	2021	Here we show that c-MYC induces biosynthesis of fatty acids and increases the rate of pentose phosphate pathway.	Pentosephosphates	86-103	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	18-23
34476741-10	2021	A high rate of aerobic glycolysis is induced by c-MYC, increasing the amounts of intracellular Glucose-6-phosphate (G6P), fructose-6-phosphate (F6P), and glyceraldehyde-3-phosphate (GA3P), which can all enter pentose phosphate pathway (PPP) to produce Ribose-5-Phosphate (R5P) and NADPH, which are necessary for the biosynthesis of biomolecules such as proteins, nucleic acids, or lipids.	Pentosephosphates	209-226	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	48-53
34476741-10	2021	A high rate of aerobic glycolysis is induced by c-MYC, increasing the amounts of intracellular Glucose-6-phosphate (G6P), fructose-6-phosphate (F6P), and glyceraldehyde-3-phosphate (GA3P), which can all enter pentose phosphate pathway (PPP) to produce Ribose-5-Phosphate (R5P) and NADPH, which are necessary for the biosynthesis of biomolecules such as proteins, nucleic acids, or lipids.	Pentosephosphates	209-226	2,4-dienoyl-CoA reductase 1	Homo sapiens	281-286
34763086-4	2021	By phosphorylating Y-Box Binding Protein 1 (YB1), Linc00173 stimulates the translation of YB1 bound glucose metabolic enzymes HK2 and G6PD, which activates glycolysis and Pentose Phosphate Pathway (PPP).	Pentosephosphates	171-188	Y-box binding protein 1	Homo sapiens	19-42
34743684-6	2021	ELOVL6 and ELOVL7 are sensitive to ROS induced depletion of cellular NADPH and insufficient regeneration via the pentose phosphate pathway and mitochondrial fatty acid oxidation.	Pentosephosphates	113-130	ELOVL fatty acid elongase 7	Homo sapiens	11-17
34763086-4	2021	By phosphorylating Y-Box Binding Protein 1 (YB1), Linc00173 stimulates the translation of YB1 bound glucose metabolic enzymes HK2 and G6PD, which activates glycolysis and Pentose Phosphate Pathway (PPP).	Pentosephosphates	171-188	long intergenic non-protein coding RNA 173	Homo sapiens	50-59
34687132-14	2021	MIAT overexpression reduced oxidative pentose phosphate pathway flux and increased oxidized/reduced glutathione ratio, the effects of which were abrogated by EGLN2 knockdown.	Pentosephosphates	38-55	myocardial infarction associated transcript	Rattus norvegicus	0-4
34763086-4	2021	By phosphorylating Y-Box Binding Protein 1 (YB1), Linc00173 stimulates the translation of YB1 bound glucose metabolic enzymes HK2 and G6PD, which activates glycolysis and Pentose Phosphate Pathway (PPP).	Pentosephosphates	171-188	Y-box binding protein 1	Homo sapiens	90-93
34763086-4	2021	By phosphorylating Y-Box Binding Protein 1 (YB1), Linc00173 stimulates the translation of YB1 bound glucose metabolic enzymes HK2 and G6PD, which activates glycolysis and Pentose Phosphate Pathway (PPP).	Pentosephosphates	171-188	hexokinase 2	Homo sapiens	126-129
34763086-4	2021	By phosphorylating Y-Box Binding Protein 1 (YB1), Linc00173 stimulates the translation of YB1 bound glucose metabolic enzymes HK2 and G6PD, which activates glycolysis and Pentose Phosphate Pathway (PPP).	Pentosephosphates	171-188	glucose-6-phosphate dehydrogenase	Homo sapiens	134-138
34790195-7	2021	Blocking glycolysis and pentose phosphate pathway (PPP) via 2-DG and NADPH production through glucose-6-phosphate dehydrogenase inhibitor resulted in significantly diminished conidial processing in wild-type BEAS-2B cells to the levels of Nlrx1-deficient BEAS-2B cells.	Pentosephosphates	24-41	glucose-6-phosphate dehydrogenase	Homo sapiens	94-127
34791557-4	2021	Activities of the pentose-phosphate pathway enzymes glucose-6-phosphate dehydrogenase and transketolase increased with increasing of tumor anaplasia.	Pentosephosphates	18-35	glucose-6-phosphate dehydrogenase	Homo sapiens	52-85
34791557-4	2021	Activities of the pentose-phosphate pathway enzymes glucose-6-phosphate dehydrogenase and transketolase increased with increasing of tumor anaplasia.	Pentosephosphates	18-35	transketolase	Homo sapiens	90-103
34790195-7	2021	Blocking glycolysis and pentose phosphate pathway (PPP) via 2-DG and NADPH production through glucose-6-phosphate dehydrogenase inhibitor resulted in significantly diminished conidial processing in wild-type BEAS-2B cells to the levels of Nlrx1-deficient BEAS-2B cells.	Pentosephosphates	24-41	NLR family member X1	Homo sapiens	239-244
34687132-14	2021	MIAT overexpression reduced oxidative pentose phosphate pathway flux and increased oxidized/reduced glutathione ratio, the effects of which were abrogated by EGLN2 knockdown.	Pentosephosphates	38-55	egl-9 family hypoxia-inducible factor 2	Rattus norvegicus	158-163
34744776-4	2021	Results: In PKD patients, decreases in late glycolysis were accompanied by accumulation of pentose phosphate pathway (PPP) metabolites, as a function of oxidant stress to purines (increased breakdown and deamination).	Pentosephosphates	91-108	protein kinase D1	Homo sapiens	12-15
34592433-5	2021	Through genome sequence comparisons and directed engineering, we determined that duplications of genes encoding engineered xylose metabolism enzymes, as well as TKL1, a gene encoding a transketolase in the pentose phosphate pathway, were the causative genetic changes for the evolved phenotype.	Pentosephosphates	206-223	transketolase TKL1	Saccharomyces cerevisiae S288C	161-165
34765603-0	2021	6-Phosphogluconolactonase Promotes Hepatocellular Carcinogenesis by Activating Pentose Phosphate Pathway.	Pentosephosphates	79-96	6-phosphogluconolactonase	Homo sapiens	0-25
34765603-3	2021	Here, by analyzing the liver cell single-cell sequencing data from HCC patients and healthy individuals, we found that 6-phosphogluconolactonase (PGLS), a cytosolic enzyme in the oxidative phase of the pentose phosphate pathway (PPP), expressing cells are associated with undifferentiated HCC subtypes.	Pentosephosphates	202-219	6-phosphogluconolactonase	Homo sapiens	119-144
34765603-3	2021	Here, by analyzing the liver cell single-cell sequencing data from HCC patients and healthy individuals, we found that 6-phosphogluconolactonase (PGLS), a cytosolic enzyme in the oxidative phase of the pentose phosphate pathway (PPP), expressing cells are associated with undifferentiated HCC subtypes.	Pentosephosphates	202-219	6-phosphogluconolactonase	Homo sapiens	146-150
34297301-6	2021	Serving as a m6A eraser, ALKBH5 demethylated the target transcript G6PD and enhanced its mRNA stability, thereby promoting G6PD translation and activating the pentose phosphate pathway (PPP).	Pentosephosphates	159-176	alkB homolog 5, RNA demethylase	Homo sapiens	25-31
34343634-9	2021	Moreover, RRP15 depletion in p53-mutant PLC5 and p53-deleted Hep3B cells induced metabolic shift from the glycolytic pentose-phosphate to mitochondrial oxidative phosphorylation via regulating a series of key genes such as HK2 and TIGAR, and thus, promoted the generation of ROS and apoptosis.	Pentosephosphates	117-134	ribosomal RNA processing 15 homolog	Homo sapiens	10-15
34343634-9	2021	Moreover, RRP15 depletion in p53-mutant PLC5 and p53-deleted Hep3B cells induced metabolic shift from the glycolytic pentose-phosphate to mitochondrial oxidative phosphorylation via regulating a series of key genes such as HK2 and TIGAR, and thus, promoted the generation of ROS and apoptosis.	Pentosephosphates	117-134	tumor protein p53	Homo sapiens	29-32
34343634-9	2021	Moreover, RRP15 depletion in p53-mutant PLC5 and p53-deleted Hep3B cells induced metabolic shift from the glycolytic pentose-phosphate to mitochondrial oxidative phosphorylation via regulating a series of key genes such as HK2 and TIGAR, and thus, promoted the generation of ROS and apoptosis.	Pentosephosphates	117-134	tumor protein p53	Homo sapiens	49-52
34765544-4	2021	Subsequently, we observed that FASN inhibition caused metabolic blockade in the rate-limiting step of the oxidative branch of the pentose phosphate pathway (oxPPP) catalyzed by phosphogluconate dehydrogenase (PGDH).	Pentosephosphates	130-147	fatty acid synthase	Homo sapiens	31-35
34765544-4	2021	Subsequently, we observed that FASN inhibition caused metabolic blockade in the rate-limiting step of the oxidative branch of the pentose phosphate pathway (oxPPP) catalyzed by phosphogluconate dehydrogenase (PGDH).	Pentosephosphates	130-147	phosphogluconate dehydrogenase	Homo sapiens	177-207
34765544-4	2021	Subsequently, we observed that FASN inhibition caused metabolic blockade in the rate-limiting step of the oxidative branch of the pentose phosphate pathway (oxPPP) catalyzed by phosphogluconate dehydrogenase (PGDH).	Pentosephosphates	130-147	phosphogluconate dehydrogenase	Homo sapiens	209-213
34593007-0	2021	PFKFB4 is overexpressed in clear-cell renal cell carcinoma promoting pentose phosphate pathway that mediates Sunitinib resistance.	Pentosephosphates	69-86	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Mus musculus	0-6
34703291-11	2021	According to gene set enrichment analysis of SLC7A5, the most significant KEGG pathway was considerably enriched in spliceosome and pentose phosphate pathway.	Pentosephosphates	132-149	solute carrier family 7 member 5	Homo sapiens	45-51
34348966-5	2021	PCK1 subsequently triggered retrograde carbon flow from gluconeogenesis to glycogenesis, glycogenolysis, and the pentose phosphate pathway.	Pentosephosphates	113-130	phosphoenolpyruvate carboxykinase 1	Homo sapiens	0-4
34363719-0	2021	Evi1 Upregulates Fbp1 and Supports Progression of Acute Myeloid Leukemia through Pentose Phosphate Pathway Activation.	Pentosephosphates	81-98	MDS1 and EVI1 complex locus	Mus musculus	0-4
34363719-3	2021	We revealed that Evi1 overexpression and Evi1-driven leukemic transformation upregulate transcription of gluconeogenesis enzyme Fbp1 and other pentose phosphate enzymes with interaction between Evi1 and enhancer region of these genes.	Pentosephosphates	143-160	MDS1 and EVI1 complex locus	Mus musculus	17-21
34363719-3	2021	We revealed that Evi1 overexpression and Evi1-driven leukemic transformation upregulate transcription of gluconeogenesis enzyme Fbp1 and other pentose phosphate enzymes with interaction between Evi1 and enhancer region of these genes.	Pentosephosphates	143-160	MDS1 and EVI1 complex locus	Mus musculus	41-45
34363719-3	2021	We revealed that Evi1 overexpression and Evi1-driven leukemic transformation upregulate transcription of gluconeogenesis enzyme Fbp1 and other pentose phosphate enzymes with interaction between Evi1 and enhancer region of these genes.	Pentosephosphates	143-160	MDS1 and EVI1 complex locus	Mus musculus	194-198
34363719-4	2021	Metabolome analysis using Evi1-overexpressing leukemia cells uncovered pentose phosphate pathway upregulation by Evi1 overexpression.	Pentosephosphates	71-88	MDS1 and EVI1 complex locus	Mus musculus	113-117
34363719-5	2021	Suppression of Fbp1 as well as pentose phosphate pathway enzymes by shRNA mediated knockdown selectively decreased Evi1-driven leukemogenesis in vitro.	Pentosephosphates	31-48	MDS1 and EVI1 complex locus	Mus musculus	115-119
34593007-9	2021	Metabolomics showed overexpressed PFKFB4 showed enriched metabolites in pentose phosphate pathway (PPP).	Pentosephosphates	72-89	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Mus musculus	34-40
34535624-1	2021	Inflammatory bowel disease (IBD) has a close association with transketolase (TKT) that links glycolysis and the pentose phosphate pathway (PPP).	Pentosephosphates	112-129	transketolase	Mus musculus	62-75
34535624-1	2021	Inflammatory bowel disease (IBD) has a close association with transketolase (TKT) that links glycolysis and the pentose phosphate pathway (PPP).	Pentosephosphates	112-129	transketolase	Mus musculus	77-80
34440853-5	2021	The increased activity of enzymes related to the pentose-phosphate route and lipid anabolism and elevated polyunsaturated fatty acid levels were found in the hypothalamus of ND IRS2-/- mice.	Pentosephosphates	49-66	insulin receptor substrate 2	Mus musculus	177-181
34572080-6	2021	Interestingly, we found that FTH1 silencing is accompanied by a significant activation of the nuclear factor (erythroid-derived-2)-like 2 (Nrf2) signaling pathway and pentose phosphate pathway (PPP), which crosstalk in driving hESCs antioxidant cascade events.	Pentosephosphates	167-184	ferritin heavy chain 1	Homo sapiens	29-33
34218200-4	2021	Mechanistically, we found that TRIM31 is an E3 ubiquitin ligase for TP53-induced glycolysis and apoptosis regulator (TIGAR), which confers protection against brain ischemia by increasing the pentose phosphate pathway flux and preserving mitochondria function.	Pentosephosphates	191-208	tripartite motif containing 31	Homo sapiens	31-37
34218200-4	2021	Mechanistically, we found that TRIM31 is an E3 ubiquitin ligase for TP53-induced glycolysis and apoptosis regulator (TIGAR), which confers protection against brain ischemia by increasing the pentose phosphate pathway flux and preserving mitochondria function.	Pentosephosphates	191-208	Cbl proto-oncogene like 2	Homo sapiens	44-63
34218200-4	2021	Mechanistically, we found that TRIM31 is an E3 ubiquitin ligase for TP53-induced glycolysis and apoptosis regulator (TIGAR), which confers protection against brain ischemia by increasing the pentose phosphate pathway flux and preserving mitochondria function.	Pentosephosphates	191-208	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	68-115
34218200-4	2021	Mechanistically, we found that TRIM31 is an E3 ubiquitin ligase for TP53-induced glycolysis and apoptosis regulator (TIGAR), which confers protection against brain ischemia by increasing the pentose phosphate pathway flux and preserving mitochondria function.	Pentosephosphates	191-208	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	117-122
34439897-6	2021	H6PD triggers a still largely uncharacterized pentose-phosphate pathway (PPP) within the endoplasmic reticulum (ER) that has been found to play a pivotal role in feeding the NADPH reductive power for both cellular proliferation and antioxidant responses.	Pentosephosphates	46-63	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	0-4
34382934-2	2021	This study provides insight into both hallmarks by uncovering a novel link between AR and the pentose phosphate pathway (PPP).	Pentosephosphates	94-111	androgen receptor	Homo sapiens	83-85
34082063-4	2021	TP53-induced glycolysis and apoptotic regulators (TIGAR) may facilitate the production of nicotinamide adenine dinucleotide phosphoric acid (NADPH) via the pentose phosphate pathway (PPP) to inhibit oxidative stress and neuroinflammation.	Pentosephosphates	156-173	tumor protein p53	Homo sapiens	0-4
34082063-4	2021	TP53-induced glycolysis and apoptotic regulators (TIGAR) may facilitate the production of nicotinamide adenine dinucleotide phosphoric acid (NADPH) via the pentose phosphate pathway (PPP) to inhibit oxidative stress and neuroinflammation.	Pentosephosphates	156-173	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	50-55
34502217-6	2021	Interestingly, combined overexpression of either hexokinase with hexose transporters significantly accelerated citric acid biosynthesis and enhanced pentose phosphate pathway leading to secretion of polyols (31.5 g/L vs. no polyols in the control strain).	Pentosephosphates	149-166	hexokinase	Saccharomyces cerevisiae S288C	49-59
34320407-1	2021	In neutrophils, nicotinamide adenine dinucleotide phosphate (NADPH) generated via the pentose phosphate pathway fuels NADPH oxidase NOX2 to produce reactive oxygen species for killing invading pathogens.	Pentosephosphates	86-103	cytochrome b-245 beta chain	Homo sapiens	132-136
34320407-3	2021	Here, we use two unbiased chemical proteomic strategies to show that small-molecule LDC7559, or a more potent designed analog NA-11, inhibits the NOX2-dependent oxidative burst in neutrophils by activating the glycolytic enzyme phosphofructokinase-1 liver type (PFKL) and dampening flux through the pentose phosphate pathway.	Pentosephosphates	299-316	cytochrome b-245 beta chain	Homo sapiens	146-150
34289240-5	2021	Consequently, infected cells rely on the parallel pentose phosphate pathway and its main product, NADPH, fueling antioxidant pathways maintaining HIV-1 latency.	Pentosephosphates	50-67	2,4-dienoyl-CoA reductase 1	Homo sapiens	98-103
34313391-0	2021	Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress-induced mitochondrial dysfunction.	Pentosephosphates	62-79	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
34313391-0	2021	Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress-induced mitochondrial dysfunction.	Pentosephosphates	62-79	2,4-dienoyl-CoA reductase 1	Homo sapiens	26-31
34313391-9	2021	While Nrf2 did not affect mitochondrial antioxidant abundance, oxidized PRX3 was magnified by Nrf2 deficiency due to decreased NADPH from decreased expression of IDH2 and pentose phosphate pathway (PPP) genes.	Pentosephosphates	171-188	NFE2 like bZIP transcription factor 2	Homo sapiens	94-98
34329340-9	2021	GSEA analysis showed that the following genes may be involved in esophageal cancer prognosis: ZBTB16 may through the MTOR signaling pathway, AQP4 through the GNRH signaling pathway, ADCYAP1R1 through the PPAR signaling pathway, VIPR2 through the P53 signaling pathway and PDGFD through the PENTOSE-PHOSPHATE signaling pathway.	Pentosephosphates	290-307	platelet derived growth factor D	Homo sapiens	272-277
34203453-2	2021	We previously demonstrated the Na/H Exchange Regulatory Factor 1 (NHERF1) loss resulted in increased kidney enzyme activity of the pentose phosphate pathway and was associated with more severe cisplatin nephrotoxicity.	Pentosephosphates	131-148	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	Mus musculus	31-64
34299050-6	2021	Principal component analysis of the cancer cells revealed that all these changes were in the first principal component (PC1) axis, where the responsible metabolites were involved in the metabolism of the arginine-proline, pyrimidine, and pentose phosphate pathways.	Pentosephosphates	238-255	proprotein convertase subtilisin/kexin type 1	Homo sapiens	120-123
34239044-6	2021	Studies revealed that TrxR directly regulates GAPDH leading to a disruption of glycolysis and an increase in flux through the pentose phosphate pathway (PPP).	Pentosephosphates	126-143	peroxiredoxin 5	Homo sapiens	22-26
34239044-6	2021	Studies revealed that TrxR directly regulates GAPDH leading to a disruption of glycolysis and an increase in flux through the pentose phosphate pathway (PPP).	Pentosephosphates	126-143	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	46-51
34354953-12	2021	It shunted the glucose flux towards the pentose phosphate pathway (PPP) by activating G6PD through OGT-promoted O-GlcNAcylation.	Pentosephosphates	40-57	glucose-6-phosphate dehydrogenase	Homo sapiens	86-90
34354953-12	2021	It shunted the glucose flux towards the pentose phosphate pathway (PPP) by activating G6PD through OGT-promoted O-GlcNAcylation.	Pentosephosphates	40-57	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	99-102
34299056-6	2021	In this model, TIGAR was found to support the activity of glucose 6-phosphate dehydrogenase (G6PDH), the first enzyme of the pentose phosphate pathway (PPP), since the inhibition of TIGAR reduced G6PDH activity and increased autophagy.	Pentosephosphates	125-142	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	15-20
34299056-6	2021	In this model, TIGAR was found to support the activity of glucose 6-phosphate dehydrogenase (G6PDH), the first enzyme of the pentose phosphate pathway (PPP), since the inhibition of TIGAR reduced G6PDH activity and increased autophagy.	Pentosephosphates	125-142	glucose-6-phosphate dehydrogenase	Homo sapiens	58-91
34299056-6	2021	In this model, TIGAR was found to support the activity of glucose 6-phosphate dehydrogenase (G6PDH), the first enzyme of the pentose phosphate pathway (PPP), since the inhibition of TIGAR reduced G6PDH activity and increased autophagy.	Pentosephosphates	125-142	glucose-6-phosphate dehydrogenase	Homo sapiens	93-98
34299056-6	2021	In this model, TIGAR was found to support the activity of glucose 6-phosphate dehydrogenase (G6PDH), the first enzyme of the pentose phosphate pathway (PPP), since the inhibition of TIGAR reduced G6PDH activity and increased autophagy.	Pentosephosphates	125-142	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	182-187
34299056-6	2021	In this model, TIGAR was found to support the activity of glucose 6-phosphate dehydrogenase (G6PDH), the first enzyme of the pentose phosphate pathway (PPP), since the inhibition of TIGAR reduced G6PDH activity and increased autophagy.	Pentosephosphates	125-142	glucose-6-phosphate dehydrogenase	Homo sapiens	196-201
34163028-6	2021	We also show that MUC1-C and PBRM1 are necessary for induction of other NRF2 target genes, including G6PD and PGD that regulate the pentose phosphate pathway.	Pentosephosphates	132-149	mucin 1, cell surface associated	Homo sapiens	18-22
34163028-6	2021	We also show that MUC1-C and PBRM1 are necessary for induction of other NRF2 target genes, including G6PD and PGD that regulate the pentose phosphate pathway.	Pentosephosphates	132-149	polybromo 1	Homo sapiens	29-34
34163028-6	2021	We also show that MUC1-C and PBRM1 are necessary for induction of other NRF2 target genes, including G6PD and PGD that regulate the pentose phosphate pathway.	Pentosephosphates	132-149	NFE2 like bZIP transcription factor 2	Homo sapiens	72-76
34203453-2	2021	We previously demonstrated the Na/H Exchange Regulatory Factor 1 (NHERF1) loss resulted in increased kidney enzyme activity of the pentose phosphate pathway and was associated with more severe cisplatin nephrotoxicity.	Pentosephosphates	131-148	SLC9A3 regulator 1	Homo sapiens	66-72
34163028-6	2021	We also show that MUC1-C and PBRM1 are necessary for induction of other NRF2 target genes, including G6PD and PGD that regulate the pentose phosphate pathway.	Pentosephosphates	132-149	glucose-6-phosphate dehydrogenase	Homo sapiens	101-105
34163028-6	2021	We also show that MUC1-C and PBRM1 are necessary for induction of other NRF2 target genes, including G6PD and PGD that regulate the pentose phosphate pathway.	Pentosephosphates	132-149	phosphoglycerate dehydrogenase	Homo sapiens	110-113
34205698-7	2021	To support these data, Western blot analysis was performed to analyze glucose-6-phosphate dehydrogenase (G6PD), TP53-induced glycolysis and the apoptosis regulator (TIGAR), and the glutamate cysteine ligase catalytic (GCLC) subunit, as they represent the main regulators of the pentose phosphate pathway (PPP) and glutathione synthesis, respectively.	Pentosephosphates	278-295	tumor protein p53	Homo sapiens	112-116
34089613-7	2022	KEY FINDINGS: The activity of glucose-6-phosphate dehydrogenase (G6PDH), a key enzyme of the pentose phosphate pathway, significantly decreased in Gem + HY groups, however, the ROS level enhanced accompanying with GSH depleting, mitochondrial membrane depolarisation and cytochrome C release.	Pentosephosphates	93-110	glucose-6-phosphate dehydrogenase	Homo sapiens	30-63
34235156-0	2021	KRT6A Promotes Lung Cancer Cell Growth and Invasion Through MYC-Regulated Pentose Phosphate Pathway.	Pentosephosphates	74-91	keratin 6A	Homo sapiens	0-5
34235156-0	2021	KRT6A Promotes Lung Cancer Cell Growth and Invasion Through MYC-Regulated Pentose Phosphate Pathway.	Pentosephosphates	74-91	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	60-63
34235156-5	2021	Mechanistically, KRT6A overexpression is sufficient to upregulate glucose-6-phosphate dehydrogenase (G6PD) levels and increase the pentose phosphate pathway flux, an essential metabolic pathway to support cancer cell growth and invasion.	Pentosephosphates	131-148	keratin 6A	Homo sapiens	17-22
34117285-6	2021	Rev-erbalpha deletion increased expression of hexokinase II, transketolase, and ribose-5-phosphate isomerase genes involved in glycolysis and the pentose phosphate pathway (PPP), and these effects were not mediated by the transcriptional activator BMAL1.	Pentosephosphates	146-163	nuclear receptor subfamily 1, group D, member 1	Mus musculus	0-12
34117285-6	2021	Rev-erbalpha deletion increased expression of hexokinase II, transketolase, and ribose-5-phosphate isomerase genes involved in glycolysis and the pentose phosphate pathway (PPP), and these effects were not mediated by the transcriptional activator BMAL1.	Pentosephosphates	146-163	ribose 5-phosphate isomerase A	Mus musculus	80-108
33735119-2	2021	Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway.	Pentosephosphates	76-93	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
33735119-2	2021	Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway.	Pentosephosphates	76-93	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
33899493-5	2021	ROS/RNS-mediated inhibition of glycolytic pathways promotes metabolic reprogramming away from glycolytic flux toward the oxidative pentose phosphate pathway to generate NADPH for antioxidant defense.	Pentosephosphates	131-148	2,4-dienoyl-CoA reductase 1	Homo sapiens	169-174
34089613-7	2022	KEY FINDINGS: The activity of glucose-6-phosphate dehydrogenase (G6PDH), a key enzyme of the pentose phosphate pathway, significantly decreased in Gem + HY groups, however, the ROS level enhanced accompanying with GSH depleting, mitochondrial membrane depolarisation and cytochrome C release.	Pentosephosphates	93-110	glucose-6-phosphate dehydrogenase	Homo sapiens	65-70
34522704-2	2021	Recent studies showed that, to prevent toxic buildup of highly insoluble cystine inside cells, cancer cells with high expression of SLC7A11 (SLC7A11high) are forced to quickly reduce cystine to more soluble cysteine, which requires substantial NADPH supply from the glucose-pentose phosphate pathway (PPP) route, thereby inducing glucose- and PPP-dependency in SLC7A11high cancer cells.	Pentosephosphates	274-291	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	132-139
34522704-2	2021	Recent studies showed that, to prevent toxic buildup of highly insoluble cystine inside cells, cancer cells with high expression of SLC7A11 (SLC7A11high) are forced to quickly reduce cystine to more soluble cysteine, which requires substantial NADPH supply from the glucose-pentose phosphate pathway (PPP) route, thereby inducing glucose- and PPP-dependency in SLC7A11high cancer cells.	Pentosephosphates	274-291	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	141-152
34522704-2	2021	Recent studies showed that, to prevent toxic buildup of highly insoluble cystine inside cells, cancer cells with high expression of SLC7A11 (SLC7A11high) are forced to quickly reduce cystine to more soluble cysteine, which requires substantial NADPH supply from the glucose-pentose phosphate pathway (PPP) route, thereby inducing glucose- and PPP-dependency in SLC7A11high cancer cells.	Pentosephosphates	274-291	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	244-249
35578850-1	2022	Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme that regulates energy metabolism mainly through the pentose phosphate pathway (PPP).	Pentosephosphates	106-123	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
35588962-0	2022	Thioredoxin 1 regulates the pentose phosphate pathway via ATM phosphorylation after experimental subarachnoid hemorrhage in rats.	Pentosephosphates	28-45	thioredoxin 1	Rattus norvegicus	0-13
35588962-0	2022	Thioredoxin 1 regulates the pentose phosphate pathway via ATM phosphorylation after experimental subarachnoid hemorrhage in rats.	Pentosephosphates	28-45	ATM serine/threonine kinase	Rattus norvegicus	58-61
35576689-0	2022	TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner.	Pentosephosphates	72-89	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	0-5
35576689-1	2022	TP53-induced glycolysis and apoptosis regulator (TIGAR) alleviates oxidative stress and protects against ischemic neuronal injury by shifting glucose metabolism into the pentose phosphate pathway (PPP).	Pentosephosphates	170-187	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	0-47
35576689-1	2022	TP53-induced glycolysis and apoptosis regulator (TIGAR) alleviates oxidative stress and protects against ischemic neuronal injury by shifting glucose metabolism into the pentose phosphate pathway (PPP).	Pentosephosphates	170-187	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	49-54
35176127-5	2022	TET2 restrained glycolysis and pentose phosphate pathway metabolism in a VHL deficiency-dependent manner, thereby suppressing ccRCC progression.	Pentosephosphates	31-48	tet methylcytosine dioxygenase 2	Homo sapiens	0-4
35578850-1	2022	Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme that regulates energy metabolism mainly through the pentose phosphate pathway (PPP).	Pentosephosphates	106-123	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
35227738-9	2022	These data support that although Nrf2 deficiency caused baseline activation of the pentose phosphate pathway and sugar alcohol synthesis, a brief exposure to none-lethal doses of H2O2 caused NAD depletion in an Nrf2 independent manner.	Pentosephosphates	83-100	NFE2 like bZIP transcription factor 2	Homo sapiens	33-37
35489641-11	2022	CONCLUSION: EEx-mediated reparations of metabolic and redox imbalance (utilization of pentose phosphate pathway), and autophagy deficiency caused by metabolic distress critically contribute to preventing/delaying severe progression of NAFLD.	Pentosephosphates	86-103	exercise endurance QTL 1	Mus musculus	12-15
35438846-12	2022	The NME1 may regulate cell cycle, DNA replication, oxidative phosphorylation, and the pentose phosphate pathway.	Pentosephosphates	86-103	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	4-8
35421237-7	2022	Investigation of SS glucose metabolism revealed that ME1 null cells exhibit higher rates of glycolysis and higher flux of glucose into the pentose phosphate pathway (PPP), which is necessary to produce NADPH.	Pentosephosphates	139-156	malic enzyme 1, NADP(+)-dependent, cytosolic	Mus musculus	53-56
35421237-7	2022	Investigation of SS glucose metabolism revealed that ME1 null cells exhibit higher rates of glycolysis and higher flux of glucose into the pentose phosphate pathway (PPP), which is necessary to produce NADPH.	Pentosephosphates	139-156	2,4-dienoyl-CoA reductase 1	Homo sapiens	202-207
35414794-0	2022	Enhanced pentose phosphate pathway activity promotes pancreatic ductal adenocarcinoma progression via activating YAP/MMP1 axis under chronic acidosis.	Pentosephosphates	9-26	Yes1 associated transcriptional regulator	Homo sapiens	113-116
35405915-0	2022	Myostatin Knockout Limits Exercise-Induced Reduction in Bovine Erythrocyte Oxidative Stress by Enhancing the Efficiency of the Pentose Phosphate Pathway.	Pentosephosphates	127-144	myostatin	Bos taurus	0-9
35405915-9	2022	Our results suggest that knockout of MSTN accelerates the pentose phosphate pathway (PPP), thereby enhancing the antioxidant capacity of erythrocytes.	Pentosephosphates	58-75	myostatin	Bos taurus	37-41
35351997-0	2022	H3K9me3 represses G6PD expression to suppress the pentose phosphate pathway and ROS production to promote human mesothelioma growth.	Pentosephosphates	50-67	glucose-6-phosphate dehydrogenase	Homo sapiens	18-22
35408935-1	2022	Increased expression of transketolase (TKT) and its isoform transketolase-like-1 (TKTL1) has been related to the malignant leukemia phenotype through promoting an increase in the non-oxidative branch of the pentose phosphate pathway (PPP).	Pentosephosphates	207-224	transketolase	Homo sapiens	24-37
35408935-1	2022	Increased expression of transketolase (TKT) and its isoform transketolase-like-1 (TKTL1) has been related to the malignant leukemia phenotype through promoting an increase in the non-oxidative branch of the pentose phosphate pathway (PPP).	Pentosephosphates	207-224	transketolase	Homo sapiens	39-42
35408935-1	2022	Increased expression of transketolase (TKT) and its isoform transketolase-like-1 (TKTL1) has been related to the malignant leukemia phenotype through promoting an increase in the non-oxidative branch of the pentose phosphate pathway (PPP).	Pentosephosphates	207-224	transketolase like 1	Homo sapiens	60-80
35408935-1	2022	Increased expression of transketolase (TKT) and its isoform transketolase-like-1 (TKTL1) has been related to the malignant leukemia phenotype through promoting an increase in the non-oxidative branch of the pentose phosphate pathway (PPP).	Pentosephosphates	207-224	transketolase like 1	Homo sapiens	82-87
35453447-6	2022	The oxidative damage matched an increased activity of G6PD, and even more of H6PD, that trigger the cytosolic and ER pentose phosphate pathways, respectively.	Pentosephosphates	117-134	glucose-6-phosphate dehydrogenase	Homo sapiens	54-58
35453447-6	2022	The oxidative damage matched an increased activity of G6PD, and even more of H6PD, that trigger the cytosolic and ER pentose phosphate pathways, respectively.	Pentosephosphates	117-134	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	77-81
35380314-1	2022	Transketolase (Tkt), an enzyme in pentose phosphate pathway, has been reported to regulate genome instability and cell survival in cancers.	Pentosephosphates	34-51	transketolase	Mus musculus	0-13
35380314-1	2022	Transketolase (Tkt), an enzyme in pentose phosphate pathway, has been reported to regulate genome instability and cell survival in cancers.	Pentosephosphates	34-51	transketolase	Mus musculus	15-18
35414794-0	2022	Enhanced pentose phosphate pathway activity promotes pancreatic ductal adenocarcinoma progression via activating YAP/MMP1 axis under chronic acidosis.	Pentosephosphates	9-26	matrix metallopeptidase 1	Homo sapiens	117-121
35110412-2	2022	To address this, we mutated the substrate binding site of glucose 6-phosphate dehydrogenase (G6PD), which catalyzes the first step of the pentose phosphate pathway, in patient-derived melanomas.	Pentosephosphates	138-155	glucose-6-phosphate dehydrogenase	Homo sapiens	58-91
35234135-1	2022	6-Phosphogluconate dehydrogenase (6PGDH; EC 1.1.1.44) catalyses the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate in the context of the oxidative part of the pentose phosphate pathway.	Pentosephosphates	184-201	6-phosphogluconate dehydrogenase, decarboxylating	Ovis aries	0-32
35234135-1	2022	6-Phosphogluconate dehydrogenase (6PGDH; EC 1.1.1.44) catalyses the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate in the context of the oxidative part of the pentose phosphate pathway.	Pentosephosphates	184-201	6-phosphogluconate dehydrogenase, decarboxylating	Ovis aries	34-39
35213227-2	2022	By combining in silico analysis of patient datasets with metabolomic profiling of prostate cancer cells cultured with bone cells, we demonstrate the changing energy requirements of prostate cancer cells in the bone microenvironment, identifying the pentose phosphate pathway (PPP) as elevated in prostate cancer bone metastasis, with increased expression of the PPP rate-limiting enzyme glucose-6-phosphate dehydrogenase (G6PD) associated with a reduction in progression-free survival.	Pentosephosphates	249-266	glucose-6-phosphate dehydrogenase	Homo sapiens	387-420
35213227-2	2022	By combining in silico analysis of patient datasets with metabolomic profiling of prostate cancer cells cultured with bone cells, we demonstrate the changing energy requirements of prostate cancer cells in the bone microenvironment, identifying the pentose phosphate pathway (PPP) as elevated in prostate cancer bone metastasis, with increased expression of the PPP rate-limiting enzyme glucose-6-phosphate dehydrogenase (G6PD) associated with a reduction in progression-free survival.	Pentosephosphates	249-266	glucose-6-phosphate dehydrogenase	Homo sapiens	422-426
35280908-2	2022	Transketolase (TKT) is a crucial enzyme in the non-oxidative phase of the Pentose Phosphate Pathway (PPP), and is up-regulated in multiple cancer types.	Pentosephosphates	74-91	transketolase	Homo sapiens	0-13
35280908-2	2022	Transketolase (TKT) is a crucial enzyme in the non-oxidative phase of the Pentose Phosphate Pathway (PPP), and is up-regulated in multiple cancer types.	Pentosephosphates	74-91	transketolase	Homo sapiens	15-18
35163828-3	2022	The TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) is an important regulator of glycolysis and the pentose phosphate pathway that was described as a p53 response gene, yet TIGAR expression is detected in p53-null tumors.	Pentosephosphates	108-125	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	4-51
35163828-3	2022	The TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) is an important regulator of glycolysis and the pentose phosphate pathway that was described as a p53 response gene, yet TIGAR expression is detected in p53-null tumors.	Pentosephosphates	108-125	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	53-58
35163828-3	2022	The TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) is an important regulator of glycolysis and the pentose phosphate pathway that was described as a p53 response gene, yet TIGAR expression is detected in p53-null tumors.	Pentosephosphates	108-125	tumor protein p53	Homo sapiens	158-161
35163828-3	2022	The TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) is an important regulator of glycolysis and the pentose phosphate pathway that was described as a p53 response gene, yet TIGAR expression is detected in p53-null tumors.	Pentosephosphates	108-125	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	181-186
35248023-5	2022	Their expression and those of a pentose phosphate shunt and related pathways required for xylose utilisation were strongly activated by the transcription factor Znf1.	Pentosephosphates	32-49	DNA-binding domain containing protein	Saccharomyces cerevisiae S288C	161-165
35134532-6	2022	Dichloroacetate reversed the increased phosphorylation of pyruvate dehydrogenase in rd10 retina and increased histone acetylation and levels of TP53-induced glycolysis and apoptosis regulator (TIGAR), which redirected glucose metabolism toward the pentose phosphate pathway.	Pentosephosphates	248-265	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	144-191
35134532-6	2022	Dichloroacetate reversed the increased phosphorylation of pyruvate dehydrogenase in rd10 retina and increased histone acetylation and levels of TP53-induced glycolysis and apoptosis regulator (TIGAR), which redirected glucose metabolism toward the pentose phosphate pathway.	Pentosephosphates	248-265	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	193-198
35203128-7	2022	Furthermore, enzyme activity associated with the TCA cycle and pentose phosphate pathway, including alpha-ketoglutaric dehydrogenase (KGDH), malate dehydrogenase (MDH), pyruvate dehydrogenase (PDH), succinate dehydrogenase (SDH), and glucose-6-phosphate dehydrogenase (G6PDH), were higher in LT. Based on these results, we conclude that there are significant differences in nucleotide metabolism and energy metabolism of LL between LT and LR, and we speculate that the enhanced nucleic acid metabolism and energy metabolism in LT can meet the material and energy requirements of rapid cell proliferation and differentiation, making myogenesis more intense in LT compared to LR which might be the metabolic mechanism underlying the distinct skeletal muscle development in the two breeds.	Pentosephosphates	63-80	malate dehydrogenase 1	Sus scrofa	141-161
35203128-7	2022	Furthermore, enzyme activity associated with the TCA cycle and pentose phosphate pathway, including alpha-ketoglutaric dehydrogenase (KGDH), malate dehydrogenase (MDH), pyruvate dehydrogenase (PDH), succinate dehydrogenase (SDH), and glucose-6-phosphate dehydrogenase (G6PDH), were higher in LT. Based on these results, we conclude that there are significant differences in nucleotide metabolism and energy metabolism of LL between LT and LR, and we speculate that the enhanced nucleic acid metabolism and energy metabolism in LT can meet the material and energy requirements of rapid cell proliferation and differentiation, making myogenesis more intense in LT compared to LR which might be the metabolic mechanism underlying the distinct skeletal muscle development in the two breeds.	Pentosephosphates	63-80	malate dehydrogenase 1	Sus scrofa	163-166
35203128-7	2022	Furthermore, enzyme activity associated with the TCA cycle and pentose phosphate pathway, including alpha-ketoglutaric dehydrogenase (KGDH), malate dehydrogenase (MDH), pyruvate dehydrogenase (PDH), succinate dehydrogenase (SDH), and glucose-6-phosphate dehydrogenase (G6PDH), were higher in LT. Based on these results, we conclude that there are significant differences in nucleotide metabolism and energy metabolism of LL between LT and LR, and we speculate that the enhanced nucleic acid metabolism and energy metabolism in LT can meet the material and energy requirements of rapid cell proliferation and differentiation, making myogenesis more intense in LT compared to LR which might be the metabolic mechanism underlying the distinct skeletal muscle development in the two breeds.	Pentosephosphates	63-80	glucose-6-phosphate dehydrogenase	Sus scrofa	234-267
35203128-7	2022	Furthermore, enzyme activity associated with the TCA cycle and pentose phosphate pathway, including alpha-ketoglutaric dehydrogenase (KGDH), malate dehydrogenase (MDH), pyruvate dehydrogenase (PDH), succinate dehydrogenase (SDH), and glucose-6-phosphate dehydrogenase (G6PDH), were higher in LT. Based on these results, we conclude that there are significant differences in nucleotide metabolism and energy metabolism of LL between LT and LR, and we speculate that the enhanced nucleic acid metabolism and energy metabolism in LT can meet the material and energy requirements of rapid cell proliferation and differentiation, making myogenesis more intense in LT compared to LR which might be the metabolic mechanism underlying the distinct skeletal muscle development in the two breeds.	Pentosephosphates	63-80	glucose-6-phosphate dehydrogenase	Sus scrofa	269-274
35110412-2	2022	To address this, we mutated the substrate binding site of glucose 6-phosphate dehydrogenase (G6PD), which catalyzes the first step of the pentose phosphate pathway, in patient-derived melanomas.	Pentosephosphates	138-155	glucose-6-phosphate dehydrogenase	Homo sapiens	93-97
35110412-3	2022	G6PD mutant melanomas had significantly decreased G6PD enzymatic activity and depletion of intermediates in the oxidative pentose phosphate pathway.	Pentosephosphates	122-139	glucose-6-phosphate dehydrogenase	Homo sapiens	0-4
35110545-1	2022	Transketolase (TKT) which is an important metabolic enzyme in the pentose phosphate pathway (PPP) participates in maintaining ribose 5-phosphate levels.	Pentosephosphates	66-83	transketolase	Homo sapiens	0-13
35110545-1	2022	Transketolase (TKT) which is an important metabolic enzyme in the pentose phosphate pathway (PPP) participates in maintaining ribose 5-phosphate levels.	Pentosephosphates	66-83	transketolase	Homo sapiens	15-18
35017152-7	2022	Tumor cells induce H3K9me3 deposition at the promoter of G6pd, the gene that encodes the rate-limiting enzyme G6PD in the pentose phosphate pathway, to downregulate G6pd expression in tumor-specific CTLs.	Pentosephosphates	122-139	glucose-6-phosphate dehydrogenase	Homo sapiens	57-61
34996938-5	2022	Hypoxia-inducible factor (HIF)-1alpha was activated and a glucose transporter and rate-limiting enzymes of the glycolytic and pentose phosphate pathways, which are HIF-1alpha-downstream targets, were upregulated in the heart primordium after heartbeat initiation.	Pentosephosphates	126-143	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-37
34996938-5	2022	Hypoxia-inducible factor (HIF)-1alpha was activated and a glucose transporter and rate-limiting enzymes of the glycolytic and pentose phosphate pathways, which are HIF-1alpha-downstream targets, were upregulated in the heart primordium after heartbeat initiation.	Pentosephosphates	126-143	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	164-174
34996938-6	2022	These results suggest that the HIF-1alpha-mediated enhancement of glycolysis with activation of the pentose phosphate pathway, potentially leading to antioxidant defense and nucleotide biosynthesis, covers the increased energy demand in the beating and developing heart primordium.	Pentosephosphates	100-117	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	31-41
34969852-3	2022	The mechanism involves Sod1-derived H2O2 oxidatively inactivating the glycolytic enzyme, GAPDH, which in turn reroutes carbohydrate flux to the oxidative phase of the pentose phosphate pathway (oxPPP) to generate NADPH.	Pentosephosphates	167-184	superoxide dismutase 1	Homo sapiens	23-27
34969852-3	2022	The mechanism involves Sod1-derived H2O2 oxidatively inactivating the glycolytic enzyme, GAPDH, which in turn reroutes carbohydrate flux to the oxidative phase of the pentose phosphate pathway (oxPPP) to generate NADPH.	Pentosephosphates	167-184	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	89-94
34969852-3	2022	The mechanism involves Sod1-derived H2O2 oxidatively inactivating the glycolytic enzyme, GAPDH, which in turn reroutes carbohydrate flux to the oxidative phase of the pentose phosphate pathway (oxPPP) to generate NADPH.	Pentosephosphates	167-184	2,4-dienoyl-CoA reductase 1	Homo sapiens	213-218
34997215-0	2022	The POU2F1-ALDOA axis promotes the proliferation and chemoresistance of colon cancer cells by enhancing glycolysis and the pentose phosphate pathway activity.	Pentosephosphates	123-140	POU class 2 homeobox 1	Homo sapiens	4-10
34997215-0	2022	The POU2F1-ALDOA axis promotes the proliferation and chemoresistance of colon cancer cells by enhancing glycolysis and the pentose phosphate pathway activity.	Pentosephosphates	123-140	aldolase, fructose-bisphosphate A	Homo sapiens	11-16
34997215-7	2022	POU2F1 enhanced the proliferation, aerobic glycolysis and the pentose phosphate pathway (PPP) activity, but reduced oxidative stress and apoptosis in colon cancer cells, dependent on up-regulating ALDOA expression.	Pentosephosphates	62-79	POU class 2 homeobox 1	Homo sapiens	0-6
34998404-9	2022	The enhanced glycolysis and pentose phosphate pathway in CRC were associated with increased HIF-1alpha expression.	Pentosephosphates	28-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	92-102
35017152-7	2022	Tumor cells induce H3K9me3 deposition at the promoter of G6pd, the gene that encodes the rate-limiting enzyme G6PD in the pentose phosphate pathway, to downregulate G6pd expression in tumor-specific CTLs.	Pentosephosphates	122-139	glucose-6-phosphate dehydrogenase	Homo sapiens	110-114
35017152-7	2022	Tumor cells induce H3K9me3 deposition at the promoter of G6pd, the gene that encodes the rate-limiting enzyme G6PD in the pentose phosphate pathway, to downregulate G6pd expression in tumor-specific CTLs.	Pentosephosphates	122-139	glucose-6-phosphate dehydrogenase	Homo sapiens	165-169
35499042-11	2022	Specifically, elevated O-GlcNAcylation increased glucose uptake via glucose transporter 1 (GLUT1) leading to glucose metabolic flow into the pentose phosphate pathways and HBP, which regulate the metabolic reprogramming of endometrial cells.	Pentosephosphates	141-158	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	68-89
34975298-2	2022	Our previous studies demonstrate that glucose-6-phosphate dehydrogenase (G6PD), the first and rate-limiting enzyme of the pentose phosphate pathway, is highly expressed in ccRCC and predicts poor outcomes of ccRCC patients.	Pentosephosphates	122-139	glucose-6-phosphate dehydrogenase	Homo sapiens	38-71
34975298-2	2022	Our previous studies demonstrate that glucose-6-phosphate dehydrogenase (G6PD), the first and rate-limiting enzyme of the pentose phosphate pathway, is highly expressed in ccRCC and predicts poor outcomes of ccRCC patients.	Pentosephosphates	122-139	glucose-6-phosphate dehydrogenase	Homo sapiens	73-77
35102339-3	2022	Here, we show that the oxidative pentose phosphate pathway (oxPPP) in endothelial cells is required for establishing vMC coverage of the dorsal aorta during early vertebrate development in zebrafish and mice.	Pentosephosphates	33-50	plexin A3	Danio rerio	117-120
35499042-11	2022	Specifically, elevated O-GlcNAcylation increased glucose uptake via glucose transporter 1 (GLUT1) leading to glucose metabolic flow into the pentose phosphate pathways and HBP, which regulate the metabolic reprogramming of endometrial cells.	Pentosephosphates	141-158	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	91-96
2730211-4	1989	At the same time it was characteristic of the resistant variants to increase the activity of the pentose phosphate cycle enzymes; glucose-6-phosphate dehydrogenase by 25-38.1 per cent transketolase by 21.5-27.3 per cent and transaldolase by 30-57.1 per cent.	Pentosephosphates	97-114	glucose-6-phosphate dehydrogenase	Homo sapiens	130-163
2774076-1	1989	Activity of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase, the enzymes participating in the pentose phosphate pathway of glucose oxidation was studied in the blood of 15 normal fetuses and 25 abortuses as well as in 80 females (20 with normally advancing pregnancy, 40 with the signs of discontinuation and 20 patients with spontaneous abortion developed during 24-26 weeks of gestation).	Pentosephosphates	117-134	glucose-6-phosphate dehydrogenase	Homo sapiens	12-45
3065197-0	1988	The effect of high glucose and high insulin concentrations on pentose phosphate shunt enzymes and malic enzyme in cultured human endothelial cells.	Pentosephosphates	62-79	insulin	Homo sapiens	36-43
3065197-1	1988	The influence of glucose and insulin on pentose phosphate shunt enzymes and malic enzyme activity in cultured human endothelial cells has been investigated.	Pentosephosphates	40-57	insulin	Homo sapiens	29-36
3366106-7	1988	The oxidative part of the pentose phosphate pathway in myopathic tissue seemed to be important in three cases, demonstrated by the increased activity of glucose-6-phosphate dehydrogenase (GPDH) and 6-phosphogluconate dehydrogenase (PGDH).	Pentosephosphates	26-43	glucose-6-phosphate dehydrogenase	Equus caballus	153-186
2843500-8	1988	These results plus the established wide distribution of glucose dehydrogenase, the microsomal glucose-6-phosphate dehydrogenase, and its localization to the lumen of the endoplasmic reticulum suggest that most mammalian cells have two sets of enzymes of the pentose phosphate pathway: one is cytoplasmic and the other is in the endoplasmic reticulum.	Pentosephosphates	258-275	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	56-77
2843500-8	1988	These results plus the established wide distribution of glucose dehydrogenase, the microsomal glucose-6-phosphate dehydrogenase, and its localization to the lumen of the endoplasmic reticulum suggest that most mammalian cells have two sets of enzymes of the pentose phosphate pathway: one is cytoplasmic and the other is in the endoplasmic reticulum.	Pentosephosphates	258-275	glucose-6-phosphate dehydrogenase	Homo sapiens	94-127
2969732-1	1988	The present study examined the effect of the aldose reductase inhibitor Statil (ICI 128436, ICI, Cheshire, U.K.) on the levels of metabolites and activities of enzymes involved in the glycolysis, polyol pathway and pentose phosphate pathway and on the flux of radioactive glucose through these pathways in kidney of streptozotocin diabetic rats.	Pentosephosphates	215-232	aldo-keto reductase family 1 member B1	Rattus norvegicus	45-61
2969922-3	1988	In vitro, it is a potent inhibitor of glucose-6-phosphate dehydrogenase, the first committed step of the pentose phosphate pathway.	Pentosephosphates	105-122	glucose-6-phosphate 1-dehydrogenase	Oryctolagus cuniculus	38-71
3382425-2	1988	This value is compatible with the kinetic parameters of both glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase from bass liver, and hence with the flux through the oxidative phase of the pentose phosphate pathway.	Pentosephosphates	208-225	glucose-6-phosphate dehydrogenase	Homo sapiens	61-94
3365274-1	1988	Glucose-6-phosphate dehydrogenase (G-6-PDH) is the key enzyme of the pentose phosphate cycle and therefore regulates the synthesis of the nucleic acid constituent ribose-5-phosphate.	Pentosephosphates	69-86	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-33
3365274-1	1988	Glucose-6-phosphate dehydrogenase (G-6-PDH) is the key enzyme of the pentose phosphate cycle and therefore regulates the synthesis of the nucleic acid constituent ribose-5-phosphate.	Pentosephosphates	69-86	glucose-6-phosphate dehydrogenase	Rattus norvegicus	35-42
3366106-7	1988	The oxidative part of the pentose phosphate pathway in myopathic tissue seemed to be important in three cases, demonstrated by the increased activity of glucose-6-phosphate dehydrogenase (GPDH) and 6-phosphogluconate dehydrogenase (PGDH).	Pentosephosphates	26-43	glucose-6-phosphate dehydrogenase	Equus caballus	188-192
3120792-7	1987	The fungal strains employ the Embden--Meyerhof pathway of glucose catabolism and the key enzymes of the pentose phosphate pathway (6-phosphogluconate dehydrogenase, glucose-6-phosphate dehydrogenase, transaldolase and transketolase).	Pentosephosphates	104-121	glucose-6-phosphate dehydrogenase	Homo sapiens	165-198
3440115-0	1987	[Formation of a pentose phosphate cycle metabolite, erythrose-4-phosphate, from initial compounds of glycolysis by transketolase from the rat liver].	Pentosephosphates	16-33	transketolase	Rattus norvegicus	115-128
3440115-1	1987	Using ion-exchange chromatography of sucrose phosphates on Dowex-1, it was demonstrated that the highly purified rat liver transketolase (specific activity 1.7 mumol/min.mg protein) is capable of catalyzing the synthesis of erythrose-4-phosphate, a metabolite of the pentose phosphate pathway non-oxidizing step, from the initial participants of glycolysis, i. e., glucose-6-phosphate and fructose-6-phosphate.	Pentosephosphates	267-284	transketolase	Rattus norvegicus	123-136
3440115-5	1987	The role of the transketolase reaction reversal from the synthesis of pentose phosphate derivatives to glycolytic products is discussed.	Pentosephosphates	70-87	transketolase	Rattus norvegicus	16-29
3440115-6	1987	The transketolase reaction provides for the relationship between glycolysis and the anaerobic step of the pentose phosphate pathway which share common metabolites, i. e. glucose-6-phosphate and fructose-6-phosphate.	Pentosephosphates	106-123	transketolase	Rattus norvegicus	4-17
2889685-3	1987	The activities of pentose phosphate enzymes, such as glucose-6-phosphate dehydrogenase and transketolase in developing human fetus reach the highest level between 25 and 28 weeks and 21 and 24 weeks of gestation, respectively, indicating the most actively synthesizing period of the fetus for providing NADPH and ribose-5-phosphate for steroidogenesis and nucleotide and nucleic acid synthesis.	Pentosephosphates	18-35	glucose-6-phosphate dehydrogenase	Homo sapiens	53-86
2889685-3	1987	The activities of pentose phosphate enzymes, such as glucose-6-phosphate dehydrogenase and transketolase in developing human fetus reach the highest level between 25 and 28 weeks and 21 and 24 weeks of gestation, respectively, indicating the most actively synthesizing period of the fetus for providing NADPH and ribose-5-phosphate for steroidogenesis and nucleotide and nucleic acid synthesis.	Pentosephosphates	18-35	transketolase	Homo sapiens	91-104
2955240-6	1987	The observation that 6AN inhibited metabolism via the pentose phosphate pathway but failed to inhibit NGF-stimulated neurite outgrowth suggests that NADPH required for lipid biosynthesis accompanying NGF-stimulated neurite outgrowth from PC12 cells can be derived from sources other than, or in addition to, the oxidative enzymes of the pentose phosphate pathway.	Pentosephosphates	337-354	nerve growth factor	Rattus norvegicus	200-203
3622907-6	1987	A contributive role for aldose reductase in the anomeric control of D-glucose 6-phosphate circulation in the pentose phosphate pathway should not be ruled out, since aldose reductase inhibitors decrease the production of 14CO2 by erythrocytes exposed to D-[U-14C]glucose.	Pentosephosphates	109-126	aldo-keto reductase family 1 member B	Homo sapiens	24-40
3505333-11	1987	Increased metabolic flux through the oxidative arm of the pentose phosphate pathway is apparently due to an altered form of G6PDH.	Pentosephosphates	58-75	glucose-6-phosphate dehydrogenase	Homo sapiens	124-129
3673705-6	1987	The stimulation of flux through the pentose phosphate pathway during the metabolism of t-butyl hydroperoxide is presented, and the increase in cellular activity of glucose-6-phosphate dehydrogenase is correlated with the increase in the level of protSSG.	Pentosephosphates	36-53	glucose-6-phosphate dehydrogenase	Homo sapiens	164-197
2960298-3	1987	The activities of beta-hydroxybutyrate dehydrogenase and glucose-6-phosphate dehydrogenase, which are involved in fatty acid utilization and in the pentose phosphate pathway, were elevated in cases of moderate hypertrophy, as were those of all redox enzymes in cases of strongly marked hypertrophy, although they were reduced in cases with signs of chronic cardiac failure despite the presence of considerable myocardial hypertrophy.	Pentosephosphates	148-165	glucose-6-phosphate dehydrogenase	Homo sapiens	57-90
3765490-2	1986	The alternations, found in the half-life period, in constant rates of synthesis and degradation of the key enzyme of the pentosephosphate pathway, correlated with a decrease of the glucose-6-phosphate dehydrogenase activity in vitamin B1 deficiency.	Pentosephosphates	121-137	glucose-6-phosphate dehydrogenase	Rattus norvegicus	181-214
2891220-6	1987	These results confirm the role of L-PK, an enzyme affecting the pentose phosphate pathway, as a negative marker of preneoplastic liver lesions.	Pentosephosphates	64-81	pyruvate kinase L/R	Rattus norvegicus	34-38
3827813-2	1986	A cofactor of Mr 10(4), characterized as a polypeptide, was found to co-operate with GSSG to prevent the inhibition of glucose-6-phosphate dehydrogenase by NADPH, in order to ensure the operation of the oxidative phase of the pentose phosphate pathway, in rat liver [Eggleston & Krebs (1974) Biochem.	Pentosephosphates	226-243	glucose-6-phosphate dehydrogenase	Rattus norvegicus	119-152
2945286-0	1986	tert.-Butyl hydroperoxide metabolism and stimulation of the pentose phosphate pathway in isolated rat hepatocytes.	Pentosephosphates	60-77	telomerase reverse transcriptase	Rattus norvegicus	0-4
2420373-1	1986	The correlation between the rates of protein and nucleic acid synthesis and the activity of the key enzymes of glycolysis (hexokinase, phosphofructokinase) and pentose phosphate cycle (glucose-6-phosphate dehydrogenase) in the mitotic cycle of human diploid fibroblasts synchronized by double thymidine block was studied.	Pentosephosphates	160-177	glucose-6-phosphate dehydrogenase	Homo sapiens	185-218
2868807-4	1986	The results are consistent with the concept that DHEA-modification of neoplastic development, as reported earlier in a number of different organs and here in the liver and thyroid, may be in some way partly mediated by changed expression of the key enzyme of the pentose phosphate pathway, G6PD, and related metabolic systems.	Pentosephosphates	263-280	glucose-6-phosphate dehydrogenase	Rattus norvegicus	290-294
24241735-5	1986	Around 70% of glucose-6-phosphate dehydrogenase and gluconate-6-phosphate dehydrogenase, two key enzymes of the oxidative pentose phosphate pathway, are located in the plastid.	Pentosephosphates	122-139	glucose-6-phosphate dehydrogenase	Homo sapiens	14-47
21164249-1	1985	Glucose 6-phosphate dehydrogenase (G6PD) is the first enzyme of the pentose phosphate pathway.	Pentosephosphates	68-85	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
21164249-1	1985	Glucose 6-phosphate dehydrogenase (G6PD) is the first enzyme of the pentose phosphate pathway.	Pentosephosphates	68-85	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
6477984-1	1984	Subcellular distribution of NADP+-dependent dehydrogenases of pentose phosphate pathway (glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase) in rat liver was studied, using differential and isopycnic centrifugation.	Pentosephosphates	62-79	glucose-6-phosphate dehydrogenase	Rattus norvegicus	89-122
3925733-6	1985	The initial enzymes of the pentose phosphate pathway, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase, have been demonstrated in mast cells.	Pentosephosphates	27-44	glucose-6-phosphate dehydrogenase	Rattus norvegicus	54-87
6526380-2	1984	Glucose 6-phosphate formed during the initial 0.5 h of reaction was heavily labelled in C-1 and thus is consistent with the prediction of the liver (L)-type pentose phosphate pathway (theoretically C-1/C-6 = 0.5).	Pentosephosphates	157-174	complement C6	Rattus norvegicus	198-205
3867194-3	1985	Addition of thrombin, following the incubation of thrombocytes with prostaglandins, removed the activating effect of the prostaglandins on the pentosephosphate pathway reactions, inhibited glutathione reductase and lactate dehydrogenase.	Pentosephosphates	143-159	coagulation factor II, thrombin	Homo sapiens	12-20
4024601-2	1985	The activity of both dehydrogenases and pentosephosphate pathway (PPhP) in erythrocyte--glucose-6-phosphate dehydrogenase (G6PD), and 6-phosphogluconate dehydrogenase (6-PGD), as well as the activity of the main generating ATP-enzyme of glycolysis--pyruvate kinase (PK) was studied.	Pentosephosphates	40-56	glucose-6-phosphate dehydrogenase	Homo sapiens	75-121
4024601-2	1985	The activity of both dehydrogenases and pentosephosphate pathway (PPhP) in erythrocyte--glucose-6-phosphate dehydrogenase (G6PD), and 6-phosphogluconate dehydrogenase (6-PGD), as well as the activity of the main generating ATP-enzyme of glycolysis--pyruvate kinase (PK) was studied.	Pentosephosphates	40-56	glucose-6-phosphate dehydrogenase	Homo sapiens	123-127
4024601-2	1985	The activity of both dehydrogenases and pentosephosphate pathway (PPhP) in erythrocyte--glucose-6-phosphate dehydrogenase (G6PD), and 6-phosphogluconate dehydrogenase (6-PGD), as well as the activity of the main generating ATP-enzyme of glycolysis--pyruvate kinase (PK) was studied.	Pentosephosphates	40-56	phosphogluconate dehydrogenase	Homo sapiens	134-166
4024601-2	1985	The activity of both dehydrogenases and pentosephosphate pathway (PPhP) in erythrocyte--glucose-6-phosphate dehydrogenase (G6PD), and 6-phosphogluconate dehydrogenase (6-PGD), as well as the activity of the main generating ATP-enzyme of glycolysis--pyruvate kinase (PK) was studied.	Pentosephosphates	40-56	phosphogluconate dehydrogenase	Homo sapiens	168-173
6964320-13	1982	The high activity of G6PD (more than 10 times that of the ovarian homogenate) suggests that the pentose phosphate shunt concerned with steroidogenesis is active in the oocyte.	Pentosephosphates	96-113	glucose-6-phosphate dehydrogenase	Rattus norvegicus	21-25
6479315-4	1984	At the same time the changes were discovered in the activity of transketolase and glucose-6-phosphate dehydrogenase limiting the pentosephosphate shunt.	Pentosephosphates	129-145	transketolase	Homo sapiens	64-77
6479315-4	1984	At the same time the changes were discovered in the activity of transketolase and glucose-6-phosphate dehydrogenase limiting the pentosephosphate shunt.	Pentosephosphates	129-145	glucose-6-phosphate dehydrogenase	Homo sapiens	82-115
6420889-4	1984	In this study reported here the activity of glucose-6-phosphate dehydrogenase, the first and rate-limiting enzyme of the oxidative pentose phosphate shunt, was very low in the human heart and was of the same order of magnitude in the myocardium of various animal species.	Pentosephosphates	131-148	glucose-6-phosphate dehydrogenase	Homo sapiens	44-77
6201197-4	1984	Since glucose-6-phosphate dehydrogenase appears to be the limiting step of glucose decay via the pentose phosphate pathway, and hexokinase is the limiting step of glycolysis, it was assumed that RNA synthesis predominantly occurs via the pentose phosphate pathway, while that of proteins via glycolysis.	Pentosephosphates	97-114	glucose-6-phosphate dehydrogenase	Rattus norvegicus	6-39
6666676-1	1983	Increased activities of liver glucose-6-phosphate dehydrogenase (G6PD, EC 1.1.1.49) and 6-phosphogluconate dehydrogenase (6PGD, EC 1.1.1.44) in the pentose phosphate cycle were accompanied with a depletion of reduced glutathione (GSH) following an intragastric administration of carbon tetrachloride (CCl4) to rats.	Pentosephosphates	148-165	C-C motif chemokine ligand 4	Rattus norvegicus	301-305
6679337-1	1983	The activity of pentose phosphate pathway enzymes (glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase) was measured in the cytosol and the particulate fractions (mitochondrial-synaptosomal and microsomal) from the cerebrum and the cerebellum of the rats aged 1, 2, 3, 6, 9 and 12 months.	Pentosephosphates	16-33	glucose-6-phosphate dehydrogenase	Rattus norvegicus	51-84
6404694-5	1983	DDT treatment also increases the activity of the pentose phosphate shunt as measured by the activity of G6PD and 6PGD.	Pentosephosphates	49-66	Zwischenferment	Drosophila melanogaster	104-108
6404694-5	1983	DDT treatment also increases the activity of the pentose phosphate shunt as measured by the activity of G6PD and 6PGD.	Pentosephosphates	49-66	Phosphogluconate dehydrogenase	Drosophila melanogaster	113-117
6219667-10	1982	When the hepatocytes are incubated with phenazine methosulphate, to stimulate the oxidative branch of the pentose phosphate cycle, the predicted relationship between (C-2/C-3) and (C-1/C-3) ratios of specific radio-activities is nearly exactly in accord with the classical pentose phosphate cycle.	Pentosephosphates	106-123	complement C2	Rattus norvegicus	167-174
6219667-10	1982	When the hepatocytes are incubated with phenazine methosulphate, to stimulate the oxidative branch of the pentose phosphate cycle, the predicted relationship between (C-2/C-3) and (C-1/C-3) ratios of specific radio-activities is nearly exactly in accord with the classical pentose phosphate cycle.	Pentosephosphates	106-123	complement C3	Rattus norvegicus	181-188
6219667-10	1982	When the hepatocytes are incubated with phenazine methosulphate, to stimulate the oxidative branch of the pentose phosphate cycle, the predicted relationship between (C-2/C-3) and (C-1/C-3) ratios of specific radio-activities is nearly exactly in accord with the classical pentose phosphate cycle.	Pentosephosphates	273-290	complement C2	Rattus norvegicus	167-174
6219667-10	1982	When the hepatocytes are incubated with phenazine methosulphate, to stimulate the oxidative branch of the pentose phosphate cycle, the predicted relationship between (C-2/C-3) and (C-1/C-3) ratios of specific radio-activities is nearly exactly in accord with the classical pentose phosphate cycle.	Pentosephosphates	273-290	complement C3	Rattus norvegicus	181-188
6589599-3	1984	Studies of the regulation of the pentose phosphate pathway led the present authors to a search for proteins that bind NADP+ and NADPH in human erythrocytes.	Pentosephosphates	33-50	2,4-dienoyl-CoA reductase 1	Homo sapiens	128-133
7113101-0	1982	[Niacin deficiency and correlation between oxidative reactions of the pentose phosphate pathway of carbohydrate metabolism and transketolase activity].	Pentosephosphates	70-87	transketolase	Rattus norvegicus	127-140
7119799-4	1982	Evidence is presented that the further metabolism of the aldehyde by aldehyde reductase and the removal of hydrogen peroxide by glutathione peroxidase both release the limitation of NADP+ availability for the pentose phosphate pathway by leading to the oxidation of NADPH.	Pentosephosphates	209-226	aldo-keto reductase family 1, member B7	Rattus norvegicus	69-87
7104035-6	1982	The activities of ribulose 5-phosphate 3-epimerase and ribose 5-phosphate ketol isomerase, enzymes further along in the pentose phosphate pathway, were not significantly affected by trans-stilbene oxide or benzil.	Pentosephosphates	120-137	ribulose-5-phosphate-3-epimerase	Rattus norvegicus	18-50
7175280-10	1982	High activity of G6PD suggests the pentose phosphate shunt concerned with steroidogenesis is active in the oocyte.	Pentosephosphates	35-52	glucose-6-phosphate dehydrogenase	Rattus norvegicus	17-21
7317524-4	1981	The Arrhenius plots for the rate of the transketolase reaction with a pentose phosphate mixture as substrate are continuous at 10-32 degrees; the activation energy is 89.9 cJ/mole, temperature index is 3.3.	Pentosephosphates	70-87	transketolase	Rattus norvegicus	40-53
6279634-4	1982	Enhanced pentose phosphate cycle activity may have been due to a selective inhibition of glutathione reductase by the ion, which was also accompanied by a fall in cellular glutathione content.	Pentosephosphates	9-26	glutathione-disulfide reductase	Rattus norvegicus	89-110
6757069-1	1982	The activities of glucose-6-phosphate dehydrogenase (GPD) and 6-phosphogluconate dehydrogenase (decarboxylating) (PGD) in Saccharomyces cerevisiae were found to change by a factor similar to the reported changes in the rate of the pentose phosphate pathway between cells grown in minimal medium and in rich medium.	Pentosephosphates	231-248	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	18-51
6757069-1	1982	The activities of glucose-6-phosphate dehydrogenase (GPD) and 6-phosphogluconate dehydrogenase (decarboxylating) (PGD) in Saccharomyces cerevisiae were found to change by a factor similar to the reported changes in the rate of the pentose phosphate pathway between cells grown in minimal medium and in rich medium.	Pentosephosphates	231-248	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	53-56
7281247-1	1981	The paper deals with the most important pentose phosphate pathway reactions of carbohydrate metabolism in tissues of the liver, spleen, bone marrow and in blood erythrocytes catalyzed by transketolase.	Pentosephosphates	40-57	transketolase	Homo sapiens	187-200
7314580-1	1981	Activity of key enzymes of pentosephosphate pathway glucose-6-phosphate dehydrogenase (G6PD) and transketolase was similar in extracts of thymus and mesenteric lymphatic ganglia.	Pentosephosphates	27-43	glucose-6-phosphate dehydrogenase	Homo sapiens	52-85
7314580-1	1981	Activity of key enzymes of pentosephosphate pathway glucose-6-phosphate dehydrogenase (G6PD) and transketolase was similar in extracts of thymus and mesenteric lymphatic ganglia.	Pentosephosphates	27-43	glucose-6-phosphate dehydrogenase	Homo sapiens	87-91
7314580-1	1981	Activity of key enzymes of pentosephosphate pathway glucose-6-phosphate dehydrogenase (G6PD) and transketolase was similar in extracts of thymus and mesenteric lymphatic ganglia.	Pentosephosphates	27-43	transketolase	Homo sapiens	97-110
7281247-2	1981	Possibilities are also studied for pentose phosphate production in the mentioned tissues in the nonoxidized reaction of the pentose phosphate pathway catalyzed by transketolase.	Pentosephosphates	35-52	transketolase	Homo sapiens	163-176
7281247-2	1981	Possibilities are also studied for pentose phosphate production in the mentioned tissues in the nonoxidized reaction of the pentose phosphate pathway catalyzed by transketolase.	Pentosephosphates	124-141	transketolase	Homo sapiens	163-176
7281247-6	1981	Coming from the data obtained the authors suggest that acceleration of the transketolase reaction towards the utilization of erythroso-4-phosphate as well as of synthesis of fructoso-6-phosphate and glyceraldehyde-3-phosphate promotes the transfer of carbohydrate metabolism from the pentose phosphate pathway to glycolysis.	Pentosephosphates	284-301	transketolase	Homo sapiens	75-88
7396409-0	1980	Biochemical genetics of the pentose phosphate cycle: human ribose 5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase (RPE).	Pentosephosphates	28-45	ribulose-5-phosphate-3-epimerase	Homo sapiens	132-135
7315103-7	1981	Stimulation of the pentose phosphate pathway (PPP) of G6PD Nucus erythrocytes insignificantly increased the rate of glucose consumption while in the case of G6PD Tashkent methylene blue raised the rate of PPP to half of the maximal rate of stimulated normal red cells.	Pentosephosphates	19-36	glucose-6-phosphate dehydrogenase	Homo sapiens	54-58
7315103-7	1981	Stimulation of the pentose phosphate pathway (PPP) of G6PD Nucus erythrocytes insignificantly increased the rate of glucose consumption while in the case of G6PD Tashkent methylene blue raised the rate of PPP to half of the maximal rate of stimulated normal red cells.	Pentosephosphates	19-36	glucose-6-phosphate dehydrogenase	Homo sapiens	157-161
7396409-0	1980	Biochemical genetics of the pentose phosphate cycle: human ribose 5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase (RPE).	Pentosephosphates	28-45	ribose 5-phosphate isomerase A	Homo sapiens	59-87
7284486-5	1981	At ATP and NADPH concentrations close to the physiological ones the Embden-Meyerhof and pentose phosphate pathways function practically independently.	Pentosephosphates	88-105	2,4-dienoyl-CoA reductase 1	Homo sapiens	11-16
6252945-5	1980	As judged by the accumulation of 6-phosphogluconate after incubation with 6-aminonicotinamide, the activity of the pentose phosphate pathway was similar in normal and G-6-PD Helsinki cells, whereas in G-6-PD Espoo cells the metabolic flux through this pathway was decreased.	Pentosephosphates	115-132	glucose-6-phosphate dehydrogenase	Homo sapiens	167-173
7396409-0	1980	Biochemical genetics of the pentose phosphate cycle: human ribose 5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase (RPE).	Pentosephosphates	28-45	ribose 5-phosphate isomerase A	Homo sapiens	89-92
7353518-1	1980	Administration of testosterone propionate to immature male rats caused a 50% increase in the specific activity of glucose 6-phosphate dehydrogenase, the rate-limiting enzyme of the pentose phosphate pathway, in the levator ani muscle.	Pentosephosphates	181-198	glucose-6-phosphate dehydrogenase	Rattus norvegicus	114-147
7396409-0	1980	Biochemical genetics of the pentose phosphate cycle: human ribose 5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase (RPE).	Pentosephosphates	28-45	ribulose-5-phosphate-3-epimerase	Homo sapiens	98-130
38988-0	1979	Relationship between the pentose phosphate shunt and methemoglobin reductase activity in human erythrocytes: Effect of aging on methemoglobin reductase activity.	Pentosephosphates	25-42	hemoglobin subunit gamma 2	Homo sapiens	53-66
7213828-0	1980	[Determination of half-life time for the key enzymes of the pentose phosphate pathway--glucose-6-phosphate dehydrogenase and transketolase].	Pentosephosphates	60-77	glucose-6-phosphate dehydrogenase	Homo sapiens	87-120
7213828-0	1980	[Determination of half-life time for the key enzymes of the pentose phosphate pathway--glucose-6-phosphate dehydrogenase and transketolase].	Pentosephosphates	60-77	transketolase	Homo sapiens	125-138
7440225-7	1980	NADPH in the red cell is generated solely by the two dehydrogenases of the pentosephosphate shunt.	Pentosephosphates	75-91	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
6248474-6	1980	The decrease in the activity of phosphofructokinase was greater than that one observed for glucose-6-phosphate dehydrogenase, indicating a shift in glucose utilization by the cells, from the glycolytic to the pentose phosphate pathway.	Pentosephosphates	209-226	glucose-6-phosphate dehydrogenase	Rattus norvegicus	91-124
6250959-10	1980	5) It is surmized that smooth endoplasmic reticulum was increased in content and pentose phosphate shunt was inhibited by chronic ethanol treatment, estimating from increased activities of NADH-ferricyanide reductase and gamma-glutamyl transpeptidase, and decreased activity of glucose-6-phosphate dehydrogenase.	Pentosephosphates	81-98	gamma-glutamyltransferase 1	Rattus norvegicus	221-250
6250959-10	1980	5) It is surmized that smooth endoplasmic reticulum was increased in content and pentose phosphate shunt was inhibited by chronic ethanol treatment, estimating from increased activities of NADH-ferricyanide reductase and gamma-glutamyl transpeptidase, and decreased activity of glucose-6-phosphate dehydrogenase.	Pentosephosphates	81-98	glucose-6-phosphate dehydrogenase	Rattus norvegicus	278-311
221244-1	1979	Experiments with rabbit platelets in vitro revealed differences in the effect of the aggregation inducers (ADP and thrombin) and the aggregation inhibitor cyclic AMP on the activity of the enzymes of pentosephosphate pathway of glucose oxidation.	Pentosephosphates	200-216	prothrombin	Oryctolagus cuniculus	115-123
221244-7	1979	Like cyclic AMP, cyclic GMP differs from ADP and thrombin in the action produced on the enzymes of pentosephosphate pathway of glucose oxidation.	Pentosephosphates	99-115	prothrombin	Oryctolagus cuniculus	49-57
24317766-10	1979	These results indicate that hydrogen peroxide interacts with reduced sulfhydryl groups which are involved in the light activation of enzymes of the Calvin cycle at the site of fructose- and sedoheptulose bisphophatase, of phosphoribulokinase, as well as in light-inactivation of oxidative pentose phosphate cycle at the site of glucose-6-phosphate dehydrogenase.	Pentosephosphates	289-306	glucose-6-phosphate dehydrogenase	Homo sapiens	328-361
97655-4	1978	A reduction of hexokinase and glucose-6-phosphate dehydrogenase limiting glycolysis and the pentose-phosphate cycle, respectively, providing energy for leukocytes and important in protein metabolism of these cells, is of great significance in the reduction of functional activity of leukocytes in the inflammatory focus in diabetes.	Pentosephosphates	92-109	hexokinase-2	Oryctolagus cuniculus	15-25
97655-4	1978	A reduction of hexokinase and glucose-6-phosphate dehydrogenase limiting glycolysis and the pentose-phosphate cycle, respectively, providing energy for leukocytes and important in protein metabolism of these cells, is of great significance in the reduction of functional activity of leukocytes in the inflammatory focus in diabetes.	Pentosephosphates	92-109	glucose-6-phosphate 1-dehydrogenase	Oryctolagus cuniculus	30-63
4154743-2	1974	A search was made for mechanisms which may exert a ;fine" control of the glucose 6-phosphate dehydrogenase reaction in rat liver, the rate-limiting step of the oxidative pentose phosphate cycle.	Pentosephosphates	170-187	glucose-6-phosphate dehydrogenase	Rattus norvegicus	73-106
182650-4	1976	The pentose phosphate, or hexose monophosphate oxidation, pathway is a major source of NADPH required for the conversion of carbohydrate to the more reduced lipids and proteins, and also furnishes the ribose and deoxyribose moieties of nucleotides and nucleic acids.	Pentosephosphates	4-21	2,4-dienoyl-CoA reductase 1	Homo sapiens	87-92
131254-3	1976	While aerobic glycolysis was unaltered, an increase in glucose-6-phosphate dehydrogenase activity was observed, i.e. the enzyme initiating the pentose-phosphate cycle.	Pentosephosphates	143-160	glucose-6-phosphate dehydrogenase	Homo sapiens	55-88
171158-8	1975	However, insulin produced no detectable accumulation of triglycerides and activated neither the pentose phosphate pathway nor oxidative decarboxylation of pyruvate.	Pentosephosphates	96-113	insulin	Homo sapiens	9-16
1022282-2	1976	The reaction products are inorganic phosphate and sedoheptulose-7-phosphate; the latter product is the substrate of the transketolase reaction during pentose phosphates production.	Pentosephosphates	150-168	transketolase	Homo sapiens	120-133
10080-19	1976	The demonstration of increased transaldolase activity in hepatomas, irrespective of the degree of tumor malignancy, differentiation, or growth rate, suggests that the reprogramming of gene expression in malignant transformation is linked with an increase in the expression of this pentose phosphate pathway enzyme...	Pentosephosphates	281-298	transaldolase 1	Rattus norvegicus	31-44
939994-2	1976	This study assesses the effect of decreased transketolase levels on the activity of the pentose phosphate cycle in murine thiamin deficient cortex and brainstem.	Pentosephosphates	88-105	transketolase	Mus musculus	44-57
939994-9	1976	These data do not support the hypothesis that in thiamin dificient rats, a decrease in cerebral transketolase activity leads to a diminished pentose phosphate cycle activity.	Pentosephosphates	141-158	transketolase	Rattus norvegicus	96-109
4154743-22	1974	The hypothesis that GSSG exerts a fine control of the pentose phosphate cycle by counteracting the NADPH inhibition of glucose 6-phosphate dehydrogenase is discussed.	Pentosephosphates	54-71	glucose-6-phosphate dehydrogenase	Rattus norvegicus	119-152
5096513-2	1971	The present study describes inhibitory effects of uremic material on nervous tissue transketolase, a thiamine-dependent enzyme of the pentose phosphate pathway which has been reported to have functional importance in the metabolism of myelinated nervous structures.	Pentosephosphates	134-151	transketolase	Homo sapiens	84-97
4404963-11	1972	The rate of glucose metabolism via the pentose phosphate cycle as well as the rate of fatty acid synthesis, however, was not affected by 6-aminonicotinamide treatment and could still be stimulated by addition of insulin.	Pentosephosphates	39-56	insulin	Homo sapiens	212-219
4264124-0	1972	[Role of transketolase in non-oxidative reactions of the pentosephosphate pathway in normal and hypertrophic heart muscle].	Pentosephosphates	57-73	transketolase	Homo sapiens	9-22
11945302-0	1968	Effect of insulin and diet on the steady state concentrations of intermediates of the pentose phosphate pathway of glucose metabolism in liver.	Pentosephosphates	86-103	insulin	Homo sapiens	10-17
5791534-3	1969	Measurements were made of the non-oxidative reactions of the pentose phosphate cycle in liver (transketolase, transaldolase, ribulose 5-phosphate epimerase and ribose 5-phosphate isomerase activities) in a variety of hormonal and nutritional conditions.	Pentosephosphates	61-78	transketolase	Rattus norvegicus	95-108
5791534-3	1969	Measurements were made of the non-oxidative reactions of the pentose phosphate cycle in liver (transketolase, transaldolase, ribulose 5-phosphate epimerase and ribose 5-phosphate isomerase activities) in a variety of hormonal and nutritional conditions.	Pentosephosphates	61-78	transaldolase 1	Rattus norvegicus	110-123
5791534-3	1969	Measurements were made of the non-oxidative reactions of the pentose phosphate cycle in liver (transketolase, transaldolase, ribulose 5-phosphate epimerase and ribose 5-phosphate isomerase activities) in a variety of hormonal and nutritional conditions.	Pentosephosphates	61-78	ribose 5-phosphate isomerase A	Rattus norvegicus	160-188
5791534-25	1969	The results are discussed in relation to the hormonal control of the non-oxidative reactions of the pentose phosphate cycle, the marked changes in transketolase activity being particularly outstanding.	Pentosephosphates	100-117	transketolase	Rattus norvegicus	147-160
4287845-10	1966	Of the enzymes of the pentose phosphate pathway, glucose 6-phosphate-dehydrogenase activity was three to five times as great whereas 6-phosphogluconate-dehydrogenase activity was the same or lower than normal liver in the ethionine-and dimethylaminoazobenzene-induced tumours respectively.	Pentosephosphates	22-39	glucose-6-phosphate dehydrogenase	Rattus norvegicus	49-82
4386676-0	1968	[The pentosephosphate pathway in glucose metabolism and its interaction with glutathione reductase in rat liver nuclei].	Pentosephosphates	5-21	glutathione-disulfide reductase	Rattus norvegicus	77-98
5810081-3	1969	Measurements were made of the activities of the enzymes of the pentose phosphate pathway concerned in both the oxidative (glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase) and the non-oxidative (ribose 5-phosphate isomerase, ribulose 5-phosphate epimerase, transketolase and transaldolase) reactions of this pathway, together with hexokinase and phosphoglucose isomerase, in adipose tissue in a variety of nutritional and hormonal conditions.	Pentosephosphates	63-80	glucose-6-phosphate dehydrogenase	Rattus norvegicus	122-155
5810081-3	1969	Measurements were made of the activities of the enzymes of the pentose phosphate pathway concerned in both the oxidative (glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase) and the non-oxidative (ribose 5-phosphate isomerase, ribulose 5-phosphate epimerase, transketolase and transaldolase) reactions of this pathway, together with hexokinase and phosphoglucose isomerase, in adipose tissue in a variety of nutritional and hormonal conditions.	Pentosephosphates	63-80	ribose 5-phosphate isomerase A	Rattus norvegicus	217-245
5810081-3	1969	Measurements were made of the activities of the enzymes of the pentose phosphate pathway concerned in both the oxidative (glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase) and the non-oxidative (ribose 5-phosphate isomerase, ribulose 5-phosphate epimerase, transketolase and transaldolase) reactions of this pathway, together with hexokinase and phosphoglucose isomerase, in adipose tissue in a variety of nutritional and hormonal conditions.	Pentosephosphates	63-80	transketolase	Rattus norvegicus	279-292
5810081-3	1969	Measurements were made of the activities of the enzymes of the pentose phosphate pathway concerned in both the oxidative (glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase) and the non-oxidative (ribose 5-phosphate isomerase, ribulose 5-phosphate epimerase, transketolase and transaldolase) reactions of this pathway, together with hexokinase and phosphoglucose isomerase, in adipose tissue in a variety of nutritional and hormonal conditions.	Pentosephosphates	63-80	transaldolase 1	Rattus norvegicus	297-310
5810081-10	1969	On the basis of activity/two fat-pads, alloxan-diabetes caused a marked decrease, to about half the control value, in the activities of all the enzymes concerned in the pentose phosphate pathway, transketolase showing the smallest decrease; hexokinase and phosphoglucose isomerase activities were also decreased.	Pentosephosphates	169-186	transketolase	Rattus norvegicus	196-209
4385221-0	1967	[Influencing by phenylhydroxylamine of the pentosephosphate pathway and glycolysis in erythrocytes during methemoglobin formation].	Pentosephosphates	43-59	hemoglobin subunit gamma 2	Homo sapiens	106-119
33964586-8	2021	Hyperglycosylation activated glucose-6-phosphate dehydrogenase (G6PDH), the rate-limiting enzyme in the pentose phosphate pathway, resulting in an upregulation of NADPH/NADP+ and GSH/GSSG couples and enhancement of redox homeostasis in the heart.	Pentosephosphates	104-121	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	163-168
34007029-0	2021	Macrophage Dicer promotes tolerogenic apoptotic cell clearance and immune tolerance by inhibiting pentose phosphate pathway activity.	Pentosephosphates	98-115	dicer 1, ribonuclease III	Homo sapiens	11-16
33326820-4	2021	G6PD is involved in the rate-limiting step of the pentose phosphate pathway, which generates reduced nicotinamide adenine dinucleotide phosphate (NADPH).	Pentosephosphates	50-67	glucose-6-phosphate dehydrogenase	Homo sapiens	0-4
33548781-7	2021	Besides, the downregulation of caspase-3 suggested a causal relationship between pyruvate accumulation, pentose phosphate pathway activation, and cell apoptosis.	Pentosephosphates	104-121	caspase 3	Mus musculus	31-40
33548781-9	2021	In conclusion, SiNPs triggered acute cytotoxicity and uterine inflammation by inducing glucose depletion and pyruvate overload in trophoblasts, which were mediated in part by Pfkl and Fbp2 via the pentose phosphate pathway.	Pentosephosphates	197-214	phosphofructokinase, liver, B-type	Mus musculus	175-179
33548781-9	2021	In conclusion, SiNPs triggered acute cytotoxicity and uterine inflammation by inducing glucose depletion and pyruvate overload in trophoblasts, which were mediated in part by Pfkl and Fbp2 via the pentose phosphate pathway.	Pentosephosphates	197-214	fructose bisphosphatase 2	Mus musculus	184-188
33979990-2	2021	A compelling model posits that - at high oxygen saturation - the N-term cytosolic domain of AE1 binds to and inhibits glycolytic enzymes, thus diverting metabolic fluxes to the pentose phosphate pathway to generate reducing equivalents.	Pentosephosphates	177-194	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	92-95
33890812-3	2021	Methods and Results: Metabolomic profiling, glucose labeling and tracing, and Seahorse extracellular flux analyses revealed that the inflammatory mediators, tumor necrosis factor alpha (TNFalpha) and lipopolysaccharide (LPS), extensively reprogram cellular metabolism, and particularly enhance glycolysis, mitochondrial oxidative phosphorylation (OXPHOS), and the pentose phosphate pathway (PPP) in primary human arterial ECs.	Pentosephosphates	364-381	tumor necrosis factor	Homo sapiens	157-184
33758056-12	2021	For first time, we show that a novel inhibitor of glucose-6-phosphate dehydrogenase, the rate-limiting enzyme in the fundamental pentose phosphate pathway, modulates DNA methylation and alleviates pulmonary artery remodeling and dilates pulmonary artery to reduce pulmonary hypertension.	Pentosephosphates	129-146	glucose-6-phosphate dehydrogenase 2	Mus musculus	50-83
33967166-7	2021	However, fluxes for the lower part of glycolysis and the TCA cycle were larger and, as a result, flux for the pentose phosphate pathway was smaller in the STL1-overexpressing RIM15 disruptant than in the strain obtained from the culture after 85 generations in ALE.	Pentosephosphates	110-127	glucose-inactivated glycerol proton symporter STL1	Saccharomyces cerevisiae S288C	155-159
33967166-7	2021	However, fluxes for the lower part of glycolysis and the TCA cycle were larger and, as a result, flux for the pentose phosphate pathway was smaller in the STL1-overexpressing RIM15 disruptant than in the strain obtained from the culture after 85 generations in ALE.	Pentosephosphates	110-127	protein kinase RIM15	Saccharomyces cerevisiae S288C	175-180
33961957-1	2021	The pentose phosphate pathway (PPP) plays a critical role by providing ribulose-5-phosphate (Ru5P) and NADPH for nucleotide synthesis and reduction energy, respectively.	Pentosephosphates	4-21	2,4-dienoyl-CoA reductase 1	Homo sapiens	103-108
33509939-4	2021	Predominantly located on the cell surface, CDCP1 lies at the nexus of key tumorigenic and metastatic signalling cascades, including the SRC/PKCdelta, PI3K/AKT, WNT, and RAS/ERK axes, the oxidative pentose phosphate pathway, and fatty acid oxidation, making important functional contributions to cancer cell survival and growth, metastasis, and treatment resistance.	Pentosephosphates	197-214	CUB domain containing protein 1	Homo sapiens	43-48
33890812-3	2021	Methods and Results: Metabolomic profiling, glucose labeling and tracing, and Seahorse extracellular flux analyses revealed that the inflammatory mediators, tumor necrosis factor alpha (TNFalpha) and lipopolysaccharide (LPS), extensively reprogram cellular metabolism, and particularly enhance glycolysis, mitochondrial oxidative phosphorylation (OXPHOS), and the pentose phosphate pathway (PPP) in primary human arterial ECs.	Pentosephosphates	364-381	tumor necrosis factor	Homo sapiens	186-194
33848380-2	2021	Transaldolase 1 (TALDO1) is a rate-limiting enzyme of the pentose phosphate pathway.	Pentosephosphates	58-75	transaldolase 1	Homo sapiens	0-15
33864084-0	2021	Metabolic imaging detects elevated glucose flux through the pentose phosphate pathway associated with TERT expression in low-grade gliomas.	Pentosephosphates	60-77	telomerase reverse transcriptase	Homo sapiens	102-106
33864084-7	2021	RESULTS: TERT expression was associated with elevated glucose flux through the pentose phosphate pathway (PPP), elevated NADPH, which is a major product of the PPP, and elevated GSH, which is maintained in a reduced state by NADPH.	Pentosephosphates	79-96	telomerase reverse transcriptase	Homo sapiens	9-13
33749780-2	2021	Pyruvate kinase M2 (PKM2), a rate-limiting enzyme in glycolysis, is critical for the metabolic shift from glycolysis to the pentose phosphate pathway under oxidative stress in cancer cell growth.	Pentosephosphates	124-141	pyruvate kinase M1/2	Homo sapiens	20-24
33937017-1	2021	Introduction: The pentose phosphate pathway (PPP) is essential for NADPH generation and redox homeostasis in cancer, including glioblastomas.	Pentosephosphates	18-35	2,4-dienoyl-CoA reductase 1	Homo sapiens	67-72
33848380-2	2021	Transaldolase 1 (TALDO1) is a rate-limiting enzyme of the pentose phosphate pathway.	Pentosephosphates	58-75	transaldolase 1	Homo sapiens	17-23
33686238-1	2021	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme in pentose phosphate pathway (PPP), excessive activation of which has been considered to be involved in tumorigenesis.	Pentosephosphates	82-99	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
33686238-1	2021	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme in pentose phosphate pathway (PPP), excessive activation of which has been considered to be involved in tumorigenesis.	Pentosephosphates	82-99	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
33869760-8	2021	The colony-forming cells did not express phosphofructokinase-1 but did express glucose-6-phosphate dehydrogenase indicating the cells relied more on the pentose phosphate pathway.	Pentosephosphates	153-170	glucose-6-phosphate dehydrogenase	Homo sapiens	79-112
33859744-8	2021	NRF2 reprograms a wide range of cancer metabolic pathways and the most notable is the pentose phosphate pathway (PPP).	Pentosephosphates	86-103	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
33723244-5	2021	The overexpression of glucose-6-phosphate dehydrogenase, encoded by G6PD or H6PD, supports the metabolic dependency of GSCs on nucleotides when cultured under acidic conditions, by enhancing the pentose phosphate pathway (PPP).	Pentosephosphates	195-212	glucose-6-phosphate dehydrogenase	Homo sapiens	22-55
33723244-5	2021	The overexpression of glucose-6-phosphate dehydrogenase, encoded by G6PD or H6PD, supports the metabolic dependency of GSCs on nucleotides when cultured under acidic conditions, by enhancing the pentose phosphate pathway (PPP).	Pentosephosphates	195-212	glucose-6-phosphate dehydrogenase	Homo sapiens	68-72
33723244-5	2021	The overexpression of glucose-6-phosphate dehydrogenase, encoded by G6PD or H6PD, supports the metabolic dependency of GSCs on nucleotides when cultured under acidic conditions, by enhancing the pentose phosphate pathway (PPP).	Pentosephosphates	195-212	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	76-80
33497360-2	2021	The pentose phosphate pathway (PPP), a metabolic pathway parallel to glycolysis, generates NADPH as a reducing equivalent and ribose 5-phosphate for nucleotide synthesis.	Pentosephosphates	4-21	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	91-96
33665691-7	2021	In the hepatopancreas, acute Cd2+ exposure decreased the pentose phosphate pathway activity and NADPH content; however, an increased G6PDH activity and NADPH content were detected in sub-chronic Cd2+ exposure (2.86 mg/L).	Pentosephosphates	57-74	CD2 molecule	Homo sapiens	29-32
33168978-5	2021	We found that TLAM inhibits phosphofructokinase-1 (PFK1), which in turn activates AMPK-mediated fatty-acid oxidation to promote oxidative phosphorylation, and redirects carbon flow from glycolysis toward the pentose phosphate pathway to reinforce anti-oxidative potential.	Pentosephosphates	208-225	phosphofructokinase, muscle	Homo sapiens	28-49
33347959-1	2021	BACKGROUND: The pentose phosphate pathway (PPP) has received significant attention because of the role of NADPH and R-5-P in the maintenance of cancer cells, which are necessary for the synthesis of fatty acids and contribute to uncontrollable proliferation.	Pentosephosphates	16-33	2,4-dienoyl-CoA reductase 1	Homo sapiens	106-111
32770699-4	2021	Bioinformatic analysis showed that a large number of abundant gut bacteria lack genes encoding a transaldolase as a key enzyme of the pentose phosphate pathway.	Pentosephosphates	134-151	transaldolase 1	Homo sapiens	97-110
33168978-5	2021	We found that TLAM inhibits phosphofructokinase-1 (PFK1), which in turn activates AMPK-mediated fatty-acid oxidation to promote oxidative phosphorylation, and redirects carbon flow from glycolysis toward the pentose phosphate pathway to reinforce anti-oxidative potential.	Pentosephosphates	208-225	phosphofructokinase, muscle	Homo sapiens	51-55
33168978-5	2021	We found that TLAM inhibits phosphofructokinase-1 (PFK1), which in turn activates AMPK-mediated fatty-acid oxidation to promote oxidative phosphorylation, and redirects carbon flow from glycolysis toward the pentose phosphate pathway to reinforce anti-oxidative potential.	Pentosephosphates	208-225	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	82-86
33557752-1	2021	BACKGROUND: We previously reported that heat shock protein 27 (HSP27) phosphorylation plays an important role in the activation of glucose-6-phosphate dehydrogenase (G6PD), resulting in the upregulation of the pentose phosphate pathway and antioxidant effects against cerebral ischemia-reperfusion injury.	Pentosephosphates	210-227	heat shock protein family B (small) member 1	Rattus norvegicus	40-61
33718341-6	2021	Through the HXT7-driven expression of a reported redox variant, XYL1-K270R, along with optimized expression of XYL2 and the downstream pentose phosphate pathway genes, a balanced xylose metabolism toward ethanol formation was achieved.	Pentosephosphates	135-152	hexose transporter HXT7	Saccharomyces cerevisiae S288C	12-16
33717180-7	2021	In patients with RA, naive CD4+ T cells exhibit inhibited glycolysis and enhanced pentose phosphate pathway (PPP) activity, leading to ROS exhaustion.	Pentosephosphates	82-99	CD4 molecule	Homo sapiens	27-30
33557752-1	2021	BACKGROUND: We previously reported that heat shock protein 27 (HSP27) phosphorylation plays an important role in the activation of glucose-6-phosphate dehydrogenase (G6PD), resulting in the upregulation of the pentose phosphate pathway and antioxidant effects against cerebral ischemia-reperfusion injury.	Pentosephosphates	210-227	heat shock protein family B (small) member 1	Rattus norvegicus	63-68
33557752-1	2021	BACKGROUND: We previously reported that heat shock protein 27 (HSP27) phosphorylation plays an important role in the activation of glucose-6-phosphate dehydrogenase (G6PD), resulting in the upregulation of the pentose phosphate pathway and antioxidant effects against cerebral ischemia-reperfusion injury.	Pentosephosphates	210-227	glucose-6-phosphate dehydrogenase	Rattus norvegicus	131-164
33557752-1	2021	BACKGROUND: We previously reported that heat shock protein 27 (HSP27) phosphorylation plays an important role in the activation of glucose-6-phosphate dehydrogenase (G6PD), resulting in the upregulation of the pentose phosphate pathway and antioxidant effects against cerebral ischemia-reperfusion injury.	Pentosephosphates	210-227	glucose-6-phosphate dehydrogenase	Rattus norvegicus	166-170
33562490-3	2021	Glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) are two key enzymes on the pentose phosphate pathway.	Pentosephosphates	114-131	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
33556078-5	2021	The Calvin cycle overlaps with the pentose phosphate pathway and glycolysis, and we could confirm positive associations with fructose-1,6-bisphosphatase, aldolase, and transketolase, constituting a conserved operon, as well as ribulose-phosphate 3-epimerase, ribose-5-phosphate isomerase, and phosphoglycerate kinase.	Pentosephosphates	35-52	transketolase	Homo sapiens	168-181
33562490-3	2021	Glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) are two key enzymes on the pentose phosphate pathway.	Pentosephosphates	114-131	glucose-6-phosphate dehydrogenase	Homo sapiens	35-40
33659884-4	2021	Instead, L-lactate deviated glucose metabolism to the pentose phosphate pathway, indicated by increased glucose-6-phosphate dehydrogenase activity while glycolysis decreased.	Pentosephosphates	54-71	glucose-6-phosphate dehydrogenase	Homo sapiens	104-137
33664869-0	2021	The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer.	Pentosephosphates	41-58	prolactin receptor	Homo sapiens	21-25
33664869-0	2021	The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer.	Pentosephosphates	41-58	NIMA related kinase 9	Homo sapiens	104-108
33664869-9	2021	13C-labeled metabolite measures, LC-MS, EdU incorporation assays and seahorse analyses were used to identify the effects of PRLR-SF on the pentose phosphate pathway and glycolysis.	Pentosephosphates	139-156	prolactin receptor	Mus musculus	124-128
33664869-14	2021	We showed that PRLR-SF reduces the expression of genes in the pentose phosphate pathway (PPP) and nucleotide biosynthesis by activating Hippo signaling.	Pentosephosphates	62-79	prolactin receptor	Homo sapiens	15-19
33510458-5	2021	TIGAR in turn facilitates pentose phosphate pathway flux to produce nicotinamide adenine dinucleotide phosphate (NADPH) and ribose, thereby promoting DNA repair, and reducing intracellular reactive oxygen species.	Pentosephosphates	26-43	TP53 induced glycolysis regulatory phosphatase	Rattus norvegicus	0-5
33614940-7	2021	The cells did not express phosphofructokinase-1 but did express glucose-6-phosphate dehydrogenase indicating the cells relied more on the pentose phosphate pathway.	Pentosephosphates	138-155	glucose-6-phosphate dehydrogenase	Homo sapiens	64-97
33139492-5	2021	Mechanistically, we found that the NRF2 target genes cytochrome P450 reductase, NQO1, and enzymes in the pentose phosphate pathway, are all responsible for the NRF2-dependent enhanced bioactivation of mitomycin C.	Pentosephosphates	105-122	NFE2 like bZIP transcription factor 2	Homo sapiens	35-39
33139492-5	2021	Mechanistically, we found that the NRF2 target genes cytochrome P450 reductase, NQO1, and enzymes in the pentose phosphate pathway, are all responsible for the NRF2-dependent enhanced bioactivation of mitomycin C.	Pentosephosphates	105-122	NAD(P)H quinone dehydrogenase 1	Homo sapiens	80-84
33139492-5	2021	Mechanistically, we found that the NRF2 target genes cytochrome P450 reductase, NQO1, and enzymes in the pentose phosphate pathway, are all responsible for the NRF2-dependent enhanced bioactivation of mitomycin C.	Pentosephosphates	105-122	NFE2 like bZIP transcription factor 2	Homo sapiens	160-164
33498665-0	2021	Oxidative Pentose Phosphate Pathway Enzyme 6-Phosphogluconate Dehydrogenase Plays a Key Role in Breast Cancer Metabolism.	Pentosephosphates	10-27	phosphogluconate dehydrogenase	Homo sapiens	43-75
32777198-1	2021	Glucose-6-phosphate dehydrogenase (G6PDH), as a key enzyme in the pentose phosphate pathway, extensively responds to the biotic and abiotic stresses.	Pentosephosphates	66-83	g6pdh	Hordeum vulgare	0-33
33049304-3	2021	Transketolase (TKT) is a key enzyme functioning between the oxidative arm and the non-oxidative arm of the pentose phosphate pathway.	Pentosephosphates	107-124	transketolase	Homo sapiens	0-13
33049304-3	2021	Transketolase (TKT) is a key enzyme functioning between the oxidative arm and the non-oxidative arm of the pentose phosphate pathway.	Pentosephosphates	107-124	transketolase	Homo sapiens	15-18
32777198-1	2021	Glucose-6-phosphate dehydrogenase (G6PDH), as a key enzyme in the pentose phosphate pathway, extensively responds to the biotic and abiotic stresses.	Pentosephosphates	66-83	g6pdh	Hordeum vulgare	35-40
33332476-3	2020	Misfolded mutant SOD1 aggregates in motor neuron (MN) mitochondria and triggers a first loop characterized by oxidative phosphorylation impairment, AMP kinase over-activation, 6-phosphofructo-2-kinase (PFK3) rise, glucose metabolism shift from pentose phosphate pathway (PPP) to glycolysis, cell redox unbalance, and further worsening of mitochondrial dysfunction.	Pentosephosphates	244-261	superoxide dismutase 1, soluble	Mus musculus	17-21
33456361-6	2021	We discovered that LPS promotes glucose consumption, lactic acid production, pentose phosphate bypass, and inhibits aerobic oxidation, by inhibiting the expression of FRA1; and that LPS promotes the growth of cervical cancer cells.	Pentosephosphates	77-94	interferon regulatory factor 6	Homo sapiens	19-22
33335166-1	2020	The relevant role of pentose phosphate pathway (PPP) in cancer metabolic reprogramming has been usually outlined by studying glucose-6-phosphate dehydrogenase (G6PD).	Pentosephosphates	21-38	glucose-6-phosphate dehydrogenase	Homo sapiens	125-158
33335166-1	2020	The relevant role of pentose phosphate pathway (PPP) in cancer metabolic reprogramming has been usually outlined by studying glucose-6-phosphate dehydrogenase (G6PD).	Pentosephosphates	21-38	glucose-6-phosphate dehydrogenase	Homo sapiens	160-164
33281747-2	2020	ChREBP is activated by raised cellular levels of phosphate ester intermediates of glycolysis, gluconeogenesis and the pentose phosphate pathway.	Pentosephosphates	118-135	MLX interacting protein-like	Mus musculus	0-6
33093921-14	2020	PKM2 silencing may alter energy metabolism in cancer cells and initiate ROS-induced apoptosis after downregulation of the pentose phosphate pathway by PKM2-siRNAs.	Pentosephosphates	122-139	pyruvate kinase M1/2	Homo sapiens	0-4
33093921-14	2020	PKM2 silencing may alter energy metabolism in cancer cells and initiate ROS-induced apoptosis after downregulation of the pentose phosphate pathway by PKM2-siRNAs.	Pentosephosphates	122-139	pyruvate kinase M1/2	Homo sapiens	151-155
33186034-4	2020	Then, to direct more carbon flux toward the pentose phosphate pathway, we reduced the expression of phosphoglucose isomerase by replacing its native promoter with a weaker promoter, and increased the expression of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase by replacing their native promoters with stronger promoters.	Pentosephosphates	44-61	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	214-247
33222382-3	2020	NADPH is produced principally by the housekeeping enzyme glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the rate-limiting step in the pentose phosphate pathway.	Pentosephosphates	145-162	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	0-5
33222382-3	2020	NADPH is produced principally by the housekeeping enzyme glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the rate-limiting step in the pentose phosphate pathway.	Pentosephosphates	145-162	glucose-6-phosphate dehydrogenase 2	Mus musculus	57-90
33222382-3	2020	NADPH is produced principally by the housekeeping enzyme glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the rate-limiting step in the pentose phosphate pathway.	Pentosephosphates	145-162	glucose-6-phosphate dehydrogenase 2	Mus musculus	92-96
32827965-10	2020	These results suggested a possible mechanism of carcinogenic: Cd-induced upregulation of CDK6 in esophageal cell lines caused PKM2 overphosphorylation inhibiting PK activity, thereby shunting glucose-derived carbon into the pentose phosphate pathway and promoting the production of NADPH and reduced glutathione (GSH) to neutralize ROS, which finally results in the inhibited apoptosis.	Pentosephosphates	224-241	cyclin dependent kinase 6	Homo sapiens	89-93
33355874-13	2020	Enhanced TIGAR expression indicates switch on pentose phosphate pathway, protection against oxidative stress to prevent apoptosis, facilitation of DNA repair and the degradation of their own organelles (autophagy).	Pentosephosphates	46-63	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	9-14
32910941-4	2020	Moreover, E2F1 induced the expression of the chromatin-binding protein, high mobility group AT-Hook 1 (HMGA1), which promoted the transcription of glucose 6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, to increase NADPH level for antioxidant defense.	Pentosephosphates	221-238	E2F transcription factor 1	Homo sapiens	10-14
32798802-3	2020	Here we describe the use of human hypoxanthine guanine phosphoribosyltransferase (HGPRT) as a ligand binding domain (LBD) protein, that acts by ligand-dependent stabilization, to build a biosensor for detection of the pentose phosphate pathway metabolite 5-phospho-alpha-D-ribose 1-diphosphate (PRPP).	Pentosephosphates	218-235	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	34-80
32798802-3	2020	Here we describe the use of human hypoxanthine guanine phosphoribosyltransferase (HGPRT) as a ligand binding domain (LBD) protein, that acts by ligand-dependent stabilization, to build a biosensor for detection of the pentose phosphate pathway metabolite 5-phospho-alpha-D-ribose 1-diphosphate (PRPP).	Pentosephosphates	218-235	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	82-87
32997205-6	2020	Additionally, glucose 6-phosphate dehydrogenase (G6PD) activity and an increased (>= 300%) lactate/pyruvate molar ratio (lac/pyr) during production cell culture correlated to disulfide reduction risk, suggesting a metabolic shift to the pentose phosphate pathway (PPP).	Pentosephosphates	237-254	glucose-6-phosphate 1-dehydrogenase	Cricetulus griseus	49-53
32910941-8	2020	Collectively, our findings demonstrate that IL-6-induced acetylation of E2F1 impairs the antioxidant capacity of RPE cells by disturbing the pentose phosphate pathway, which elucidates a relationship between the intraocular microenvironment and RPE oxidative damage in AMD and provides a possible therapeutic target for AMD.	Pentosephosphates	141-158	interleukin 6	Homo sapiens	44-48
32910941-8	2020	Collectively, our findings demonstrate that IL-6-induced acetylation of E2F1 impairs the antioxidant capacity of RPE cells by disturbing the pentose phosphate pathway, which elucidates a relationship between the intraocular microenvironment and RPE oxidative damage in AMD and provides a possible therapeutic target for AMD.	Pentosephosphates	141-158	E2F transcription factor 1	Homo sapiens	72-76
32910941-4	2020	Moreover, E2F1 induced the expression of the chromatin-binding protein, high mobility group AT-Hook 1 (HMGA1), which promoted the transcription of glucose 6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, to increase NADPH level for antioxidant defense.	Pentosephosphates	221-238	high mobility group AT-hook 1	Homo sapiens	72-101
32910941-4	2020	Moreover, E2F1 induced the expression of the chromatin-binding protein, high mobility group AT-Hook 1 (HMGA1), which promoted the transcription of glucose 6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, to increase NADPH level for antioxidant defense.	Pentosephosphates	221-238	high mobility group AT-hook 1	Homo sapiens	103-108
32910941-4	2020	Moreover, E2F1 induced the expression of the chromatin-binding protein, high mobility group AT-Hook 1 (HMGA1), which promoted the transcription of glucose 6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, to increase NADPH level for antioxidant defense.	Pentosephosphates	221-238	glucose-6-phosphate dehydrogenase	Homo sapiens	147-180
32910941-4	2020	Moreover, E2F1 induced the expression of the chromatin-binding protein, high mobility group AT-Hook 1 (HMGA1), which promoted the transcription of glucose 6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, to increase NADPH level for antioxidant defense.	Pentosephosphates	221-238	glucose-6-phosphate dehydrogenase	Homo sapiens	182-186
32910941-4	2020	Moreover, E2F1 induced the expression of the chromatin-binding protein, high mobility group AT-Hook 1 (HMGA1), which promoted the transcription of glucose 6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, to increase NADPH level for antioxidant defense.	Pentosephosphates	221-238	2,4-dienoyl-CoA reductase 1	Homo sapiens	260-265
33014154-17	2020	GSEA showed that high expression of UBE2T was associated with the Kyoto Encyclopedia of Genes and Genomes pathways "cell cycle", "oxidative phosphorylation", "DNA replication", "p53 signaling pathway", "ubiquitin mediated proteolysis" and "pentose phosphate pathway".	Pentosephosphates	240-257	ubiquitin conjugating enzyme E2 T	Homo sapiens	36-41
33080927-4	2020	Notably, NRF2 regulates the pentose phosphate pathway, NADPH production, glutaminolysis, lipid and amino acid metabolism, many of which are hijacked by cancer cells to promote proliferation and survival.	Pentosephosphates	28-45	NFE2 like bZIP transcription factor 2	Homo sapiens	9-13
33092650-6	2020	RESULTS: Administering a novel, potent, and orally available CD38 antagonist to MDX mice successfully reverted a majority of the muscle metabolome toward the wildtype state, with a pronounced impact on intermediates of the pentose phosphate pathway, while supplementing nicotinamide riboside did not significantly affect the molecular phenotype of the muscle.	Pentosephosphates	223-240	CD38 antigen	Mus musculus	61-65
33142766-3	2020	Indeed, previous studies reported a close link between FDG uptake and activation of a specific pentose phosphate pathway (PPP), triggered by hexose-6P-dehydrogenase (H6PD) and contributing to fuel NADPH-dependent antioxidant responses in the endoplasmic reticulum (ER).	Pentosephosphates	95-112	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Mus musculus	141-164
33142766-3	2020	Indeed, previous studies reported a close link between FDG uptake and activation of a specific pentose phosphate pathway (PPP), triggered by hexose-6P-dehydrogenase (H6PD) and contributing to fuel NADPH-dependent antioxidant responses in the endoplasmic reticulum (ER).	Pentosephosphates	95-112	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Mus musculus	166-170
33142766-3	2020	Indeed, previous studies reported a close link between FDG uptake and activation of a specific pentose phosphate pathway (PPP), triggered by hexose-6P-dehydrogenase (H6PD) and contributing to fuel NADPH-dependent antioxidant responses in the endoplasmic reticulum (ER).	Pentosephosphates	95-112	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	197-202
33123534-1	2020	Glucose-6-phosphate dehydrogenase (G6PDH) is the rate-limiting enzyme in the pentose phosphate pathway (PPP) and plays a crucial role in the maintenance of redox homeostasis by producing nicotinamide adenine dinucleotide phosphate (NADPH), the major intracellular reductant.	Pentosephosphates	77-94	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
33045974-5	2021	OBJECTIVE: The current study is to investigate the effect of knocking-down pancreatic cancer glycolytic and pentose phosphate pathway"s regulators (HIF-1alpha, ARNT, PFKFB4, and RBKS), on cell"s viability and resistance to gemcitabine and doxorubicin, using small interference RNA.	Pentosephosphates	108-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-158
33045974-5	2021	OBJECTIVE: The current study is to investigate the effect of knocking-down pancreatic cancer glycolytic and pentose phosphate pathway"s regulators (HIF-1alpha, ARNT, PFKFB4, and RBKS), on cell"s viability and resistance to gemcitabine and doxorubicin, using small interference RNA.	Pentosephosphates	108-125	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	160-164
33045974-5	2021	OBJECTIVE: The current study is to investigate the effect of knocking-down pancreatic cancer glycolytic and pentose phosphate pathway"s regulators (HIF-1alpha, ARNT, PFKFB4, and RBKS), on cell"s viability and resistance to gemcitabine and doxorubicin, using small interference RNA.	Pentosephosphates	108-125	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Homo sapiens	166-172
33045974-5	2021	OBJECTIVE: The current study is to investigate the effect of knocking-down pancreatic cancer glycolytic and pentose phosphate pathway"s regulators (HIF-1alpha, ARNT, PFKFB4, and RBKS), on cell"s viability and resistance to gemcitabine and doxorubicin, using small interference RNA.	Pentosephosphates	108-125	ribokinase	Homo sapiens	178-182
33123534-1	2020	Glucose-6-phosphate dehydrogenase (G6PDH) is the rate-limiting enzyme in the pentose phosphate pathway (PPP) and plays a crucial role in the maintenance of redox homeostasis by producing nicotinamide adenine dinucleotide phosphate (NADPH), the major intracellular reductant.	Pentosephosphates	77-94	glucose-6-phosphate dehydrogenase	Homo sapiens	35-40
32719549-1	2020	BACKGROUND: As the rate-limit enzyme of the pentose phosphate pathway, glucose-6-phosphate dehydrogenase (G6PD) plays important roles in tumour progression, but the exact mechanism through which G6PD controls cancer metastasis remains unclear.	Pentosephosphates	44-61	glucose-6-phosphate dehydrogenase	Homo sapiens	71-104
32719549-1	2020	BACKGROUND: As the rate-limit enzyme of the pentose phosphate pathway, glucose-6-phosphate dehydrogenase (G6PD) plays important roles in tumour progression, but the exact mechanism through which G6PD controls cancer metastasis remains unclear.	Pentosephosphates	44-61	glucose-6-phosphate dehydrogenase	Homo sapiens	106-110
32719549-1	2020	BACKGROUND: As the rate-limit enzyme of the pentose phosphate pathway, glucose-6-phosphate dehydrogenase (G6PD) plays important roles in tumour progression, but the exact mechanism through which G6PD controls cancer metastasis remains unclear.	Pentosephosphates	44-61	glucose-6-phosphate dehydrogenase	Homo sapiens	195-199
32835622-1	2022	Glucose-6-phosphate dehydrogenase (G6PD) is the first rate-limiting enzyme in the pentose phosphate pathway.	Pentosephosphates	82-99	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
32937931-0	2020	NHERF1 Loss Upregulates Enzymes of the Pentose Phosphate Pathway in Kidney Cortex.	Pentosephosphates	39-56	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	Mus musculus	0-6
32829780-1	2020	BACKGROUND: The essential role of 6-phosphogluconate dehydrogenase (6PGD), the enzyme catalyzing the oxidative pentose phosphate pathway, in tumor growth and metabolism has garnered attention in recent years.	Pentosephosphates	111-128	phosphogluconate dehydrogenase	Homo sapiens	34-66
32829780-1	2020	BACKGROUND: The essential role of 6-phosphogluconate dehydrogenase (6PGD), the enzyme catalyzing the oxidative pentose phosphate pathway, in tumor growth and metabolism has garnered attention in recent years.	Pentosephosphates	111-128	phosphogluconate dehydrogenase	Homo sapiens	68-72
32997407-14	2020	Glucose uptake, glycolysis, and pentose phosphate pathway were elevated in Sirt5-/- ADMSCs.	Pentosephosphates	32-49	sirtuin 5	Mus musculus	75-80
31383940-4	2020	Knockdown (KD) of AOX1 in normal bladder epithelial cells re-wires the tryptophan-kynurenine pathway resulting in elevated NADP levels which may increase metabolic flux through the pentose phosphate (PPP) pathway, enabling increased nucleotide synthesis, and promoting cell invasion.	Pentosephosphates	181-198	aldehyde oxidase 1	Homo sapiens	18-22
31383940-4	2020	Knockdown (KD) of AOX1 in normal bladder epithelial cells re-wires the tryptophan-kynurenine pathway resulting in elevated NADP levels which may increase metabolic flux through the pentose phosphate (PPP) pathway, enabling increased nucleotide synthesis, and promoting cell invasion.	Pentosephosphates	200-203	aldehyde oxidase 1	Homo sapiens	18-22
31383940-6	2020	Ectopic AOX1 expression decreases NADP production, PPP flux and nucleotide synthesis, while decreasing invasion in cell line models and suppressing growth in tumor xenografts.	Pentosephosphates	51-54	aldehyde oxidase 1	Homo sapiens	8-12
32853822-3	2020	Macrophages activation under FBW7 deficiency decreases substrate flux through the pentose phosphate pathway (PPP) to produce less equivalents (NADPH and GSH) and aggravate the generation of intracellular reactive oxygen species (ROS) in macrophages, thereby over-activating proinflammatory reaction.	Pentosephosphates	82-99	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	143-148
33005744-0	2020	Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress.	Pentosephosphates	10-27	2,4-dienoyl-CoA reductase 1	Homo sapiens	97-102
33005744-6	2020	Utilizing 13C glucose isotopic tracers, we found increased activity in the pentose phosphate pathway (PPP) accompanied small decreases in the mitochondrial NADPH pool, whereas larger decreases induced both PPP activity and glucose anaplerosis.	Pentosephosphates	75-92	2,4-dienoyl-CoA reductase 1	Homo sapiens	156-161
32155663-7	2020	Moreover, HSP60 silencing influenced the synthesis of ribonucleotides and nicotinamide adenine dinucleotide phosphate (NADPH) by the pentose phosphate pathway to inhibit cell proliferation.	Pentosephosphates	133-150	heat shock protein family D (Hsp60) member 1	Homo sapiens	10-15
32855642-7	2020	Although HK2 is crucial for the pentose phosphate pathway (PPP) and glycolysis, the ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG) was unexpectedly higher in the hearts of transgenic mice.	Pentosephosphates	32-49	hexokinase 2	Mus musculus	9-12
32835622-1	2022	Glucose-6-phosphate dehydrogenase (G6PD) is the first rate-limiting enzyme in the pentose phosphate pathway.	Pentosephosphates	82-99	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
32535103-4	2020	In this study, we demonstrated that the oxidative pentose phosphate pathway (PPP) enzyme glucose-6-phosphate dehydrogenase (G6PD) promotes paclitaxel resistance.	Pentosephosphates	50-67	glucose-6-phosphate dehydrogenase	Homo sapiens	89-122
32864161-6	2020	Inhibition of glucose conversion to glucose-6-phosphate or pentose phosphate pathway also repressed the formation of c-Kit+ differentiating germ cells, suggesting that metabolites produced from glycolysis are required for spermatogonial differentiation.	Pentosephosphates	59-76	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	117-122
32649885-3	2020	During initiation, genetic changes enable cell survival under high ROS levels by activating antioxidant transcription factors or increasing NADPH via the pentose phosphate pathway (PPP).	Pentosephosphates	154-171	2,4-dienoyl-CoA reductase 1	Homo sapiens	140-145
32535103-4	2020	In this study, we demonstrated that the oxidative pentose phosphate pathway (PPP) enzyme glucose-6-phosphate dehydrogenase (G6PD) promotes paclitaxel resistance.	Pentosephosphates	50-67	glucose-6-phosphate dehydrogenase	Homo sapiens	124-128
32319593-1	2020	Glucose-6-phosphate dehydrogenase (G6PD) is crucial rate-limiting enzyme of the pentose phosphate pathway (PPP).	Pentosephosphates	80-97	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
32330465-4	2020	By performing ribosome profiling in human CD4+ Th1 cells, we show that the metabolism of glucose, fatty acids and pentose phosphates is regulated at the translational level.	Pentosephosphates	114-132	CD4 molecule	Homo sapiens	42-45
32507041-10	2020	In summary, a mutation resulting in the replacement of a single amino acid (S188F) in G6PD, the rate-limiting enzyme in the pentose phosphate pathway, ascribed properties to the vascular smooth muscle that shields the organism from risk factors associated with vascular diseases.	Pentosephosphates	124-141	glucose-6-phosphate dehydrogenase	Rattus norvegicus	86-90
32418907-7	2020	Further, enzymatic assays showed significantly decreased activity of transketolase indicating a disruption of the Pentose Phosphate Pathway and diversion of intermediates into purine metabolic pathway, resulting in the generation of the potentially pro-convulsant metabolites.	Pentosephosphates	114-131	transketolase	Homo sapiens	69-82
32645959-5	2020	In order to prevent further ROS generation, cancer cells rely on more glycolysis to produce ATP and on the pentose phosphate pathway to provide NADPH.	Pentosephosphates	107-124	2,4-dienoyl-CoA reductase 1	Homo sapiens	144-149
32416165-8	2020	An increased level of transketolase along with the reduced pyruvate kinase level suggested an activated pentose phosphate pathway in CSIS-resilient relative to control rats.	Pentosephosphates	104-121	transketolase	Rattus norvegicus	22-35
32730314-7	2020	This study confirmed the perturbed pentose phosphate pathway, contributing to defects observed in Ts1Cje neurospheres.	Pentosephosphates	35-52	reciprocal translocation, Chr 12 and 16, Epstein 1	Mus musculus	98-104
31504235-3	2020	Here we report that YTH domain family 2 (YTHDF2) is upregulated in lung cancer tissues, promotes lung cancer cell growth, and enhances the pentose phosphate pathway (PPP) flux, which is crucial for tumor growth.	Pentosephosphates	139-156	YTH N6-methyladenosine RNA binding protein 2	Homo sapiens	20-39
31504235-3	2020	Here we report that YTH domain family 2 (YTHDF2) is upregulated in lung cancer tissues, promotes lung cancer cell growth, and enhances the pentose phosphate pathway (PPP) flux, which is crucial for tumor growth.	Pentosephosphates	139-156	YTH N6-methyladenosine RNA binding protein 2	Homo sapiens	41-47
32442021-2	2020	Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway, is the primary source and regulator of cellular NADPH.	Pentosephosphates	74-91	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-33
32442021-2	2020	Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway, is the primary source and regulator of cellular NADPH.	Pentosephosphates	74-91	glucose-6-phosphate dehydrogenase	Rattus norvegicus	35-39
32319593-1	2020	Glucose-6-phosphate dehydrogenase (G6PD) is crucial rate-limiting enzyme of the pentose phosphate pathway (PPP).	Pentosephosphates	80-97	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
32165409-5	2020	Molecular profiling by RNA-seq, ChIP-seq, and metabolomics revealed that glycolytic and pentose phosphate pathway genes are induced by dERR, and their reduced expression in mutants is accompanied by elevated glycolytic intermediates, reduced TCA cycle intermediates, and reduced levels of long chain fatty acids.	Pentosephosphates	88-105	estrogen-related receptor	Drosophila melanogaster	135-139
32487689-5	2020	Importantly, combinatorial pharmacologic inhibition of pentose phosphate pathway and FAO with clinically available drugs efficiently reverts Snail-mediated metabolic reprogramming and suppresses in vivo metastatic progression of breast cancer cells.	Pentosephosphates	55-72	snail family transcriptional repressor 1	Homo sapiens	141-146
32393898-0	2020	A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway.	Pentosephosphates	61-78	glucose-6-phosphate dehydrogenase	Homo sapiens	17-21
32393898-2	2020	The first step of the oxidative pentose phosphate pathway is catalyzed by the enzyme glucose-6-phosphate dehydrogenase (G6PD).	Pentosephosphates	32-49	glucose-6-phosphate dehydrogenase	Homo sapiens	85-118
32393898-2	2020	The first step of the oxidative pentose phosphate pathway is catalyzed by the enzyme glucose-6-phosphate dehydrogenase (G6PD).	Pentosephosphates	32-49	glucose-6-phosphate dehydrogenase	Homo sapiens	120-124
32483148-7	2020	Survival upon nutrient stress or pentose phosphate pathway (PPP) inhibition depends on compensatory NADPH production through the mitochondrial one-carbon metabolism that is severely compromised in CI mutant cells.	Pentosephosphates	33-50	2,4-dienoyl-CoA reductase 1	Homo sapiens	100-105
32171858-5	2020	PGM1 expression was also found to be critical for lung cancer glycolysis, the oxidative pentose phosphate pathway, and oxidative phosphorylation under glucose deprivation conditions, and further led to the aberrant expression of metabolic enzymes involved in glucose metabolism mediated by ERK1/2.	Pentosephosphates	88-105	phosphoglucomutase 1	Homo sapiens	0-4
32346295-12	2020	Due to the essential role of G6PD in the pentose phosphate pathway (PPP), depletion of OR3A4 inhibited NADPH production, glucose consumption and lactate generation.	Pentosephosphates	41-58	glucose-6-phosphate dehydrogenase	Homo sapiens	29-33
32365991-7	2020	Among these essential genes is ribulose-5-phosphate-3-epimerase (RPE), which encodes a pentose phosphate pathway enzyme and whose role in cancer is still unclear.	Pentosephosphates	87-104	ribulose-5-phosphate-3-epimerase	Homo sapiens	31-63
32365991-7	2020	Among these essential genes is ribulose-5-phosphate-3-epimerase (RPE), which encodes a pentose phosphate pathway enzyme and whose role in cancer is still unclear.	Pentosephosphates	87-104	ribulose-5-phosphate-3-epimerase	Homo sapiens	65-68
32312982-2	2020	Here, we demonstrate the important reciprocal crosstalk between the PI3K/AKT signal and pentose phosphate pathway (PPP) branching metabolic pathways.	Pentosephosphates	88-105	AKT serine/threonine kinase 1	Homo sapiens	73-76
32346295-12	2020	Due to the essential role of G6PD in the pentose phosphate pathway (PPP), depletion of OR3A4 inhibited NADPH production, glucose consumption and lactate generation.	Pentosephosphates	41-58	olfactory receptor family 3 subfamily A member 4 pseudogene	Homo sapiens	87-92
32174950-1	2020	Glucose-6-phosphate dehydrogenase (G6PDH) is known as a critical enzyme responsible for nicotinamide adenine dinucleotide phosphate (NADPH) generation in the pentose phosphate pathway (PPP), and has an essential function in modulating redox homeostasis and stress responsiveness.	Pentosephosphates	158-175	glucose-6-phosphate dehydrogenase	Glycine max	0-33
32231310-7	2020	Our results identify a coupling between SLC7A11-associated cystine metabolism and the pentose phosphate pathway, and uncover an accompanying metabolic vulnerability for therapeutic targeting in SLC7A11high cancers.	Pentosephosphates	86-103	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	40-47
32139610-7	2020	Notably, Mtb infected CSE-/- macrophages show increased flux through glycolysis and the pentose phosphate pathway, thereby establishing a critical link between H2S and central metabolism.	Pentosephosphates	88-105	cystathionase (cystathionine gamma-lyase)	Mus musculus	22-25
32102234-1	2020	Glucose-6-Phosphate Dehydrogenase (G6PD) is a ubiquitous cytoplasmic enzyme converting glucose-6-phosphate into 6-phosphogluconate in the pentose phosphate pathway (PPP).	Pentosephosphates	138-155	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
32102234-1	2020	Glucose-6-Phosphate Dehydrogenase (G6PD) is a ubiquitous cytoplasmic enzyme converting glucose-6-phosphate into 6-phosphogluconate in the pentose phosphate pathway (PPP).	Pentosephosphates	138-155	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
32197068-6	2020	In addition, glucose-dependent nucleotide synthesis by the pentose phosphate pathway (PPP), along with sphingolipid (S1P) signaling, activates mTOR and allows translation of Tfap2c.	Pentosephosphates	59-76	mechanistic target of rapamycin kinase	Homo sapiens	143-147
32197068-6	2020	In addition, glucose-dependent nucleotide synthesis by the pentose phosphate pathway (PPP), along with sphingolipid (S1P) signaling, activates mTOR and allows translation of Tfap2c.	Pentosephosphates	59-76	transcription factor AP-2 gamma	Homo sapiens	174-180
32193458-0	2020	Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer.	Pentosephosphates	29-46	Rac family small GTPase 1	Homo sapiens	0-4
32193458-3	2020	Mechanistically, Rac1 activates aldolase A and ERK signaling which up-regulates glycolysis and especially the non-oxidative pentose phosphate pathway (PPP).	Pentosephosphates	124-141	Rac family small GTPase 1	Homo sapiens	17-21
32193458-3	2020	Mechanistically, Rac1 activates aldolase A and ERK signaling which up-regulates glycolysis and especially the non-oxidative pentose phosphate pathway (PPP).	Pentosephosphates	124-141	mitogen-activated protein kinase 1	Homo sapiens	47-50
32542097-5	2020	Next, pentose phosphate pathway and co-expression networks were constructed to identify key targets of lncRNA PTTG3P.	Pentosephosphates	6-23	pituitary tumor-transforming 3, pseudogene	Homo sapiens	110-116
31862471-6	2020	RESULTS: We observe that mitochondria isolated from p53 over-expressing cells accumulate Pentose phosphate Pathway (PPP) enzymes including glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) which led to enhanced mitochondrial NADPH production only when cells are cultured in sucrose but not glycerol.	Pentosephosphates	89-106	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	139-172
31862471-6	2020	RESULTS: We observe that mitochondria isolated from p53 over-expressing cells accumulate Pentose phosphate Pathway (PPP) enzymes including glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) which led to enhanced mitochondrial NADPH production only when cells are cultured in sucrose but not glycerol.	Pentosephosphates	89-106	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	174-179
32174950-1	2020	Glucose-6-phosphate dehydrogenase (G6PDH) is known as a critical enzyme responsible for nicotinamide adenine dinucleotide phosphate (NADPH) generation in the pentose phosphate pathway (PPP), and has an essential function in modulating redox homeostasis and stress responsiveness.	Pentosephosphates	158-175	glucose-6-phosphate dehydrogenase	Glycine max	35-40
31112799-6	2020	A role of cytoplasmic p53 in autophagy, pentose phosphate pathway, fatty acid synthesis and oxidation, and drug response has been proposed.	Pentosephosphates	40-57	tumor protein p53	Homo sapiens	22-25
31806376-7	2020	Proteomic and metabolite analysis using LC/MS and GC/MS revealed that Flcn inactivation in salivary gland triggers metabolic reprogramming towards the pentose phosphate pathway which consequently upregulates nucleotide synthesis and redox regulation, further supporting that Flcn controls metabolic homeostasis in salivary gland.	Pentosephosphates	151-168	folliculin	Mus musculus	70-74
31806376-7	2020	Proteomic and metabolite analysis using LC/MS and GC/MS revealed that Flcn inactivation in salivary gland triggers metabolic reprogramming towards the pentose phosphate pathway which consequently upregulates nucleotide synthesis and redox regulation, further supporting that Flcn controls metabolic homeostasis in salivary gland.	Pentosephosphates	151-168	folliculin	Mus musculus	275-279
31892224-2	2019	It has been reported that G. lamblia exhibits glucose-6-phosphate dehydrogenase (G6PD), the first enzyme in the pentose phosphate pathway (PPP).	Pentosephosphates	112-129	glucose-6-phosphate dehydrogenase	Homo sapiens	81-85
32828637-1	2020	Inborn errors of metabolism (IEM) involving the non-oxidative pentose phosphate pathway (PPP) include the two relatively rare conditions, transketolase deficiency and transaldolase deficiency, both of which can be difficult to diagnosis given their non-specific clinical presentations.	Pentosephosphates	62-79	transketolase	Homo sapiens	138-151
31871320-6	2020	As a result, FoxO1 and PGC-1alpha cooperatively upregulate Pck1 expression, therefore directing the carbon flow along the gluconeogenic pathway to glycogen and the pentose phosphate pathway.	Pentosephosphates	164-181	forkhead box O1	Homo sapiens	13-18
31871320-6	2020	As a result, FoxO1 and PGC-1alpha cooperatively upregulate Pck1 expression, therefore directing the carbon flow along the gluconeogenic pathway to glycogen and the pentose phosphate pathway.	Pentosephosphates	164-181	PPARG coactivator 1 alpha	Homo sapiens	23-33
31871320-6	2020	As a result, FoxO1 and PGC-1alpha cooperatively upregulate Pck1 expression, therefore directing the carbon flow along the gluconeogenic pathway to glycogen and the pentose phosphate pathway.	Pentosephosphates	164-181	phosphoenolpyruvate carboxykinase 1	Homo sapiens	59-63
31918925-10	2020	By contrast, it closely agreed with the catalytic function of hexose-6P-dehydrogenase (H6PD; i.e., the trigger of a specific pentose phosphate pathway selectively located within the endoplasmic reticulum).	Pentosephosphates	125-142	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Mus musculus	87-91
31853067-6	2020	In addition, inhibition of MCT1 suppressed the oxidative pentose phosphate pathway and increased levels of reactive oxygen species.	Pentosephosphates	57-74	modifier of curly tail 1	Mus musculus	27-31
31734159-3	2019	Deletion of pentose phosphate pathway genes GND1 or ZWF1 causes hypersensitivity to isobutanol but not to ethanol.	Pentosephosphates	12-29	phosphogluconate dehydrogenase (decarboxylating) GND1	Saccharomyces cerevisiae S288C	44-48
31734159-3	2019	Deletion of pentose phosphate pathway genes GND1 or ZWF1 causes hypersensitivity to isobutanol but not to ethanol.	Pentosephosphates	12-29	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	52-56
31790421-8	2019	RESULTS: In CHOW-fed mice, AAV8.Ucn2 gene transfer (vs. saline) altered the metabolites in glycolysis, pentose phosphate, glycogen synthesis, glycogenolysis, and choline-folate-methionine signaling pathways.	Pentosephosphates	103-120	urocortin 2	Mus musculus	32-36
31600627-5	2019	Furthermore, inhibiting glucose-6-phosphate dehydrogenase (G6PD) in the pentose phosphate pathway with dehydroandrosterone (DHEA) and knockdown of G6PD transcripts gradually decreased NADPH when diamide was added to living cells.	Pentosephosphates	72-89	glucose-6-phosphate dehydrogenase	Homo sapiens	24-57
31600627-5	2019	Furthermore, inhibiting glucose-6-phosphate dehydrogenase (G6PD) in the pentose phosphate pathway with dehydroandrosterone (DHEA) and knockdown of G6PD transcripts gradually decreased NADPH when diamide was added to living cells.	Pentosephosphates	72-89	glucose-6-phosphate dehydrogenase	Homo sapiens	59-63
31600627-5	2019	Furthermore, inhibiting glucose-6-phosphate dehydrogenase (G6PD) in the pentose phosphate pathway with dehydroandrosterone (DHEA) and knockdown of G6PD transcripts gradually decreased NADPH when diamide was added to living cells.	Pentosephosphates	72-89	glucose-6-phosphate dehydrogenase	Homo sapiens	147-151
31890679-1	2019	Purpose: Glucose-6-phosphate dehydrogenase (G6PD) is the regulating enzyme in the pentose phosphate pathway.	Pentosephosphates	82-99	glucose-6-phosphate dehydrogenase	Homo sapiens	9-42
31675245-11	2019	The present study proposes a link between PPARgamma gene expression level and motility in human sperm.Abbreviations: PPARs: Peroxisome Proliferator-Activated Receptors; CASA: Computer Assisted Semen Analysis; TFA: Trans Fatty Acids; HTF: Human Tubal Fluid; PBS: Phosphate-Buffered Saline; PPP: Pentose Phosphate Pathway; PI3K: Phosphoinositide 3-Kinase; G6PDH: Glucose 6-Phosphate Dehydrogenase.	Pentosephosphates	294-311	peroxisome proliferator activated receptor gamma	Homo sapiens	42-51
31585507-3	2019	RNA sequencing-based transcriptome analysis identified the up-regulation of the pentose phosphate pathway (PPP) and the antioxidant defense protein by PlGF blockade.	Pentosephosphates	80-97	placental growth factor	Homo sapiens	151-155
31229500-5	2019	Functionally, overexpression of KDM5B in melanoma cells led to broadening of their oxidative metabolism from mainly glutamine-dependent to additionally glucose- and fatty acid-utilizing, upregulation of the pentose phosphate pathway as a source of antioxidant NADPH, and maintenance of a high ratio of reduced to oxidized glutathione.	Pentosephosphates	207-224	lysine demethylase 5B	Homo sapiens	32-37
31890679-1	2019	Purpose: Glucose-6-phosphate dehydrogenase (G6PD) is the regulating enzyme in the pentose phosphate pathway.	Pentosephosphates	82-99	glucose-6-phosphate dehydrogenase	Homo sapiens	44-48
31253668-3	2019	PRPS1 participates in the pentose phosphate pathway (PPP) by catalyzing the phosphoribosylation of D-ribose 5-phosphate (R-5P) to 5-phosphoribosyl-1-pyrophosphate.	Pentosephosphates	26-43	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	0-5
32117550-2	2019	Glucose-6-phosphate dehydrogenase (G6PD) produces nicotinamide adenine dinucleotide phosphate (NADPH) via the pentose phosphate pathway.	Pentosephosphates	110-127	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
32117550-2	2019	Glucose-6-phosphate dehydrogenase (G6PD) produces nicotinamide adenine dinucleotide phosphate (NADPH) via the pentose phosphate pathway.	Pentosephosphates	110-127	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
31420217-2	2019	Here, we find that lipopolysaccharide (LPS) activates the pentose phosphate pathway, the serine synthesis pathway, and one-carbon metabolism, the synergism of which drives epigenetic reprogramming for interleukin-1beta (IL-1beta) expression.	Pentosephosphates	58-75	interleukin 1 beta	Homo sapiens	201-218
31420217-2	2019	Here, we find that lipopolysaccharide (LPS) activates the pentose phosphate pathway, the serine synthesis pathway, and one-carbon metabolism, the synergism of which drives epigenetic reprogramming for interleukin-1beta (IL-1beta) expression.	Pentosephosphates	58-75	interleukin 1 alpha	Homo sapiens	220-228
31519898-5	2019	Keap1 loss activates the pentose phosphate pathway, inhibition of which, using 6-AN, abrogated tumor growth.	Pentosephosphates	25-42	kelch like ECH associated protein 1	Homo sapiens	0-5
31404823-17	2019	Pentose phosphate pathway functions in antioxidation to protect both the spermatozoa and epididymis from oxidative damage; it was among top five KEGG pathways for DEGs in the caput vs cauda pair.	Pentosephosphates	0-17	delta 4-desaturase, sphingolipid 1	Homo sapiens	163-167
31404823-18	2019	Our results also showed that down-regulated genes in the caput vs cauda pair such as TALDO1 was found to be involved in the Pentose phosphate pathway.	Pentosephosphates	124-141	transaldolase 1	Homo sapiens	85-91
31768345-0	2019	Effects of a DPP4 Inhibitor on Progression of NASH-related HCC and the p62/ Keap1/Nrf2-Pentose Phosphate Pathway in a Mouse Model.	Pentosephosphates	87-104	nucleoporin 62	Mus musculus	71-74
31768345-0	2019	Effects of a DPP4 Inhibitor on Progression of NASH-related HCC and the p62/ Keap1/Nrf2-Pentose Phosphate Pathway in a Mouse Model.	Pentosephosphates	87-104	nuclear factor, erythroid derived 2, like 2	Mus musculus	82-86
31575908-4	2019	Furthermore, our data indicate that CD98hc sustains glucose uptake and glycolysis, and, as a consequence, the pentose phosphate pathway (PPP).	Pentosephosphates	110-127	solute carrier family 3 member 2	Homo sapiens	36-42
31119791-2	2019	Furthermore, TIGAR participated in promoting the pentose phosphate pathway and help in lowering intracellular reactive oxygen species.	Pentosephosphates	49-66	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	13-18
31328803-4	2019	PKM2 inhibition increases substrate flux through the pentose phosphate pathway to generate reducing equivalents (NADPH and GSH) and protect against oxidative stress.	Pentosephosphates	53-70	pyruvate kinase, muscle	Mus musculus	0-4
31328803-4	2019	PKM2 inhibition increases substrate flux through the pentose phosphate pathway to generate reducing equivalents (NADPH and GSH) and protect against oxidative stress.	Pentosephosphates	53-70	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	113-118
31488102-11	2019	Interestingly, FOXO3 activated not only reactive oxygen species (ROS)-promoting pathways, but also ROS-eliminating systems, which can be associated with the activation of the pentose phosphate pathway.	Pentosephosphates	175-192	forkhead box O3	Homo sapiens	15-20
31431543-3	2019	We characterized the sequence of molecular events that connected the induced CD44Hi phenotype to increased activity of both the glycolytic and oxidative pathways and glucose flux through the pentose phosphate pathway (PPP).	Pentosephosphates	191-208	CD44 molecule (Indian blood group)	Homo sapiens	77-81
31127649-1	2019	Glucose-6-phosphate dehydrogenase (G6PD), the rate limiting enzyme that channels glucose catabolism from glycolysis into the pentose phosphate pathway (PPP), is vital for the production of reduced nicotinamide adenine dinucleotide phosphate (NADPH) in cells.	Pentosephosphates	125-142	glucose-6-phosphate dehydrogenase 2	Mus musculus	0-33
31127649-1	2019	Glucose-6-phosphate dehydrogenase (G6PD), the rate limiting enzyme that channels glucose catabolism from glycolysis into the pentose phosphate pathway (PPP), is vital for the production of reduced nicotinamide adenine dinucleotide phosphate (NADPH) in cells.	Pentosephosphates	125-142	glucose-6-phosphate dehydrogenase 2	Mus musculus	35-39
31461438-0	2019	Targeting oxidative pentose phosphate pathway prevents recurrence in mutant Kras colorectal carcinomas.	Pentosephosphates	20-37	KRAS proto-oncogene, GTPase	Rattus norvegicus	76-80
31461438-5	2019	Mechanistically, glucose catabolism in CDCP1+ CSCs is routed to the oxidative pentose phosphate pathway (PPP); multiple cycling of carbon backbones in the oxidative PPP potentially maximizes NADPH reduction to counteract chemotherapy-induced reactive oxygen species (ROS) formation, thereby allowing CDCP1+ CSCs to survive chemotherapeutic attack.	Pentosephosphates	78-95	CUB domain containing protein 1	Rattus norvegicus	39-44
30998289-7	2019	We noted that LINC00504 regulates metabolism at a transcriptional level which influences multiple metabolic pathways, such as glucose metabolism, pentose phosphate pathway, and tricarboxylic acid cycle.	Pentosephosphates	146-163	long intergenic non-protein coding RNA 504	Homo sapiens	14-23
31433975-6	2019	This occurs by activation of mTORC1 signaling, which directly mediates increased translation of the mRNA encoding ribose-5-phosphate isomerase A (RPIA), a pentose phosphate pathway enzyme.	Pentosephosphates	155-172	CREB regulated transcription coactivator 1	Mus musculus	29-35
31433975-6	2019	This occurs by activation of mTORC1 signaling, which directly mediates increased translation of the mRNA encoding ribose-5-phosphate isomerase A (RPIA), a pentose phosphate pathway enzyme.	Pentosephosphates	155-172	ribose 5-phosphate isomerase A	Homo sapiens	114-144
31433975-6	2019	This occurs by activation of mTORC1 signaling, which directly mediates increased translation of the mRNA encoding ribose-5-phosphate isomerase A (RPIA), a pentose phosphate pathway enzyme.	Pentosephosphates	155-172	ribose 5-phosphate isomerase A	Homo sapiens	146-150
31456661-4	2019	TP53-inducible glycolysis and apoptosis regulator (TIGAR) is an endogenous inhibitor of glycolysis and increases the flux of pentose phosphate pathway (PPP) by regulating glucose 6-phosphate dehydrogenase (G6PD).	Pentosephosphates	125-142	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	0-49
31456661-4	2019	TP53-inducible glycolysis and apoptosis regulator (TIGAR) is an endogenous inhibitor of glycolysis and increases the flux of pentose phosphate pathway (PPP) by regulating glucose 6-phosphate dehydrogenase (G6PD).	Pentosephosphates	125-142	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	51-56
31456661-4	2019	TP53-inducible glycolysis and apoptosis regulator (TIGAR) is an endogenous inhibitor of glycolysis and increases the flux of pentose phosphate pathway (PPP) by regulating glucose 6-phosphate dehydrogenase (G6PD).	Pentosephosphates	125-142	glucose-6-phosphate dehydrogenase 2	Mus musculus	171-204
31456661-4	2019	TP53-inducible glycolysis and apoptosis regulator (TIGAR) is an endogenous inhibitor of glycolysis and increases the flux of pentose phosphate pathway (PPP) by regulating glucose 6-phosphate dehydrogenase (G6PD).	Pentosephosphates	125-142	glucose-6-phosphate dehydrogenase 2	Mus musculus	206-210
31160088-1	2019	TP53-induced glycolysis and apoptosis regulator (TIGAR) activates the pentose phosphate pathway (PPP), which feeds reduced nicotinamide adenine dinucleotide phosphate (NADPH) to the antioxidant glutathione pathway.	Pentosephosphates	70-87	TP53 induced glycolysis regulatory phosphatase	Rattus norvegicus	0-47
31415630-3	2019	Transketolase (TKT) is a thiamine pyrophosphate (vitamin B1)-dependent enzyme that links the pentose phosphate pathway with the glycolytic pathway by feeding excess sugar phosphates into the main carbohydrate metabolic pathways to generate biosynthetic reducing capacity in the form of NADPH as a substrate for ROS generation.	Pentosephosphates	93-110	transketolase	Homo sapiens	0-13
31415630-3	2019	Transketolase (TKT) is a thiamine pyrophosphate (vitamin B1)-dependent enzyme that links the pentose phosphate pathway with the glycolytic pathway by feeding excess sugar phosphates into the main carbohydrate metabolic pathways to generate biosynthetic reducing capacity in the form of NADPH as a substrate for ROS generation.	Pentosephosphates	93-110	transketolase	Homo sapiens	15-18
30685842-0	2019	Impaired Pentose Phosphate Pathway in the Spinal Cord of the hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis.	Pentosephosphates	9-26	superoxide dismutase 1	Homo sapiens	61-66
30685842-6	2019	In the spinal cord, the levels of pentose phosphate pathway (PPP) intermediate ribose 5-phosphate (p = 0.037) were reduced by 37% in hSOD1G93A mice, while the % 13C enrichments in glucose 6-phosphate were increased threefold.	Pentosephosphates	34-51	superoxide dismutase 1	Homo sapiens	133-138
31247379-1	2019	Ribose 5-phosphate isomerase deficiency is a rare genetic leukoencephalopathy caused by pathogenic sequence variants in RPIA, that encodes ribose 5-phosphate isomerase, an enzyme in the pentose phosphate pathway.	Pentosephosphates	186-203	ribose 5-phosphate isomerase A	Homo sapiens	120-124
31247379-1	2019	Ribose 5-phosphate isomerase deficiency is a rare genetic leukoencephalopathy caused by pathogenic sequence variants in RPIA, that encodes ribose 5-phosphate isomerase, an enzyme in the pentose phosphate pathway.	Pentosephosphates	186-203	ribose 5-phosphate isomerase A	Homo sapiens	139-167
31160088-1	2019	TP53-induced glycolysis and apoptosis regulator (TIGAR) activates the pentose phosphate pathway (PPP), which feeds reduced nicotinamide adenine dinucleotide phosphate (NADPH) to the antioxidant glutathione pathway.	Pentosephosphates	70-87	TP53 induced glycolysis regulatory phosphatase	Rattus norvegicus	49-54
31285420-0	2019	4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis.	Pentosephosphates	68-85	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	0-35
31028868-3	2019	FTR is the main reductant for Trxs in chloroplasts, while the flavoprotein NTRC integrates NTR and Trx activity, and plays multiple roles in the Calvin cycle, the oxidative pentose phosphate pathway (OPPP), anti-peroxidation, tetrapyrrole metabolism, ATP and starch synthesis, and photoperiodic regulation.	Pentosephosphates	173-190	neurotensin receptor 1	Homo sapiens	75-78
30868898-1	2019	Two pentose phosphate pathway-related proteins, NF-E2-related factor 2 (Nrf2)/ NAD(P)H dehydrogenase (Quinone) 1 (NQO1) regulate the expression of glucose metabolism and antioxidant genes.	Pentosephosphates	4-21	NFE2 like bZIP transcription factor 2	Homo sapiens	48-70
30868898-1	2019	Two pentose phosphate pathway-related proteins, NF-E2-related factor 2 (Nrf2)/ NAD(P)H dehydrogenase (Quinone) 1 (NQO1) regulate the expression of glucose metabolism and antioxidant genes.	Pentosephosphates	4-21	NFE2 like bZIP transcription factor 2	Homo sapiens	72-76
30868898-1	2019	Two pentose phosphate pathway-related proteins, NF-E2-related factor 2 (Nrf2)/ NAD(P)H dehydrogenase (Quinone) 1 (NQO1) regulate the expression of glucose metabolism and antioxidant genes.	Pentosephosphates	4-21	NAD(P)H quinone dehydrogenase 1	Homo sapiens	79-112
30868898-1	2019	Two pentose phosphate pathway-related proteins, NF-E2-related factor 2 (Nrf2)/ NAD(P)H dehydrogenase (Quinone) 1 (NQO1) regulate the expression of glucose metabolism and antioxidant genes.	Pentosephosphates	4-21	NAD(P)H quinone dehydrogenase 1	Homo sapiens	114-118
31101762-2	2019	The metabolic enzyme transketolase (TKT) in the nonoxidative branch of the pentose phosphate pathway (PPP) regulates ribose 5-phosphate (R5P) levels and de novo nucleotide biosynthesis.	Pentosephosphates	75-92	transketolase	Mus musculus	21-34
31101762-2	2019	The metabolic enzyme transketolase (TKT) in the nonoxidative branch of the pentose phosphate pathway (PPP) regulates ribose 5-phosphate (R5P) levels and de novo nucleotide biosynthesis.	Pentosephosphates	75-92	transketolase	Mus musculus	36-39
31285420-0	2019	4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis.	Pentosephosphates	68-85	serine/threonine kinase 11	Homo sapiens	117-121
31285420-0	2019	4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis.	Pentosephosphates	68-85	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	122-126
31285420-0	2019	4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis.	Pentosephosphates	68-85	histone deacetylase 10	Homo sapiens	127-133
31285420-0	2019	4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis.	Pentosephosphates	68-85	glucose-6-phosphate dehydrogenase	Homo sapiens	134-138
31139900-5	2019	We found a distinctive protein expression of glucose-6-phosphate dehydrogenase (Zwf1) in Y-50049 but not in Y-12632, in the relatively conserved glycolysis and pentose phosphate pathway (PPP) in response to a combinational challenge of 2-furaldehyde (furfural) and 5-hydroxymethyl-2-furaldehyde (HMF).	Pentosephosphates	160-177	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	45-78
31139900-5	2019	We found a distinctive protein expression of glucose-6-phosphate dehydrogenase (Zwf1) in Y-50049 but not in Y-12632, in the relatively conserved glycolysis and pentose phosphate pathway (PPP) in response to a combinational challenge of 2-furaldehyde (furfural) and 5-hydroxymethyl-2-furaldehyde (HMF).	Pentosephosphates	160-177	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	80-84
31002814-6	2019	Inversely, the CD34+ SVF-cells showed higher capacities for cytosolic carbohydrate metabolism, represented by the activity of glycolysis and the pentose phosphate pathway.	Pentosephosphates	145-162	CD34 molecule	Homo sapiens	15-19
31002814-7	2019	Thus, the CD34+ SVF-cells may ensure the provision of pentose phosphates and reduction equivalents for the replication of DNA during proliferation.	Pentosephosphates	54-72	CD34 molecule	Homo sapiens	10-14
31171656-5	2019	Glucose-6-phosphate dehydrogenase (G6PDH) catalyzes the first step of the oxidative pentose phosphate pathway (OPPP).	Pentosephosphates	84-101	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
30977208-6	2019	We utilized Fanca-/- HSCs deficient for p53 to show that the p53-TIGAR axis suppressed glycolysis in FA HSCs, leading to enhanced pentose phosphate pathway and cellular antioxidant function and, consequently, reduced DNA damage and attenuated HSC exhaustion.	Pentosephosphates	130-147	transformation related protein 53	Mus musculus	61-64
30977208-6	2019	We utilized Fanca-/- HSCs deficient for p53 to show that the p53-TIGAR axis suppressed glycolysis in FA HSCs, leading to enhanced pentose phosphate pathway and cellular antioxidant function and, consequently, reduced DNA damage and attenuated HSC exhaustion.	Pentosephosphates	130-147	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	65-70
31171656-5	2019	Glucose-6-phosphate dehydrogenase (G6PDH) catalyzes the first step of the oxidative pentose phosphate pathway (OPPP).	Pentosephosphates	84-101	glucose-6-phosphate dehydrogenase	Homo sapiens	35-40
30810280-5	2019	We find that these animals exhibit a delayed age-related decline in protein turnover rates, as well as decreased steady-state neuronal glucose-6-phosphate levels and elevated carbon flux into the pentose phosphate pathway due to the induction of glucose-6-phosphate dehydrogenase (G6PD).	Pentosephosphates	196-213	Zwischenferment	Drosophila melanogaster	246-279
30741526-0	2019	Cdh1-Mediated Metabolic Switch from Pentose Phosphate Pathway to Glycolysis Contributes to Sevoflurane-Induced Neuronal Apoptosis in Developing Brain.	Pentosephosphates	36-53	cadherin 1	Mus musculus	0-4
30755473-6	2019	Furthermore, promoter-activation assays showed that MYB99 directs precursor supply from the Calvin cycle and oxidative pentose-phosphate pathway in primary metabolism to phenylpropanoid biosynthesis by controlling TRANSKETOLASE2 expression.	Pentosephosphates	119-136	myb domain protein 99	Arabidopsis thaliana	52-57
31156341-1	2019	Background: The study aimed to investigate whether timolol-treatment has a beneficial effect on pentose phosphate pathway enzyme activities such as glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGDH) enzyme activities and cAMP level in streptozotocin-induced diabetic rats in pancreatic tissues.	Pentosephosphates	96-113	glucose-6-phosphate dehydrogenase	Rattus norvegicus	148-181
31156341-1	2019	Background: The study aimed to investigate whether timolol-treatment has a beneficial effect on pentose phosphate pathway enzyme activities such as glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGDH) enzyme activities and cAMP level in streptozotocin-induced diabetic rats in pancreatic tissues.	Pentosephosphates	96-113	glucose-6-phosphate dehydrogenase	Rattus norvegicus	183-187
30462889-5	2019	RESULTS: CaMK4 inhibition significantly decreased the levels of glycolytic intermediates such as glucose-6-phosphate, fructose-6-phosphate, fructose-1,6-diphosphate, pyruvate, and lactate (P < 0.05), whereas it did not affect the levels of the pentose phosphate pathway intermediates such as 6-phospho-d-gluconate, ribulose-5-phosphate, ribose-5-phosphate, and phosphoribosyl pyrophosphate.	Pentosephosphates	247-264	calcium/calmodulin dependent protein kinase IV	Homo sapiens	9-14
30924859-3	2019	Stb5 activates expression of multiple genes encoding enzymes within the pentose phosphate pathway (PPP) and other NADPH-producing reactions.	Pentosephosphates	72-89	Stb5p	Saccharomyces cerevisiae S288C	0-4
30847992-8	2019	Moreover, pentose phosphate pathway (PPP) metabolic flux was enhanced through upregulating glucose-6-phosphate dehydrogenase activity.	Pentosephosphates	10-27	glucose-6-phosphate dehydrogenase	Homo sapiens	91-124
30809937-4	2019	Inhibition of Nrf2 and overexpression of Kelch-like ECH-associated protein 1 (Keap1) reduced the expression of glucose-6-phosphate dehydrogenase (G6PD) and transketolase of pentose phosphate pathway, and overexpression of Nrf2 and knockdown of Keap1 had opposite effects.	Pentosephosphates	173-190	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
30809937-4	2019	Inhibition of Nrf2 and overexpression of Kelch-like ECH-associated protein 1 (Keap1) reduced the expression of glucose-6-phosphate dehydrogenase (G6PD) and transketolase of pentose phosphate pathway, and overexpression of Nrf2 and knockdown of Keap1 had opposite effects.	Pentosephosphates	173-190	kelch like ECH associated protein 1	Homo sapiens	41-76
30809937-4	2019	Inhibition of Nrf2 and overexpression of Kelch-like ECH-associated protein 1 (Keap1) reduced the expression of glucose-6-phosphate dehydrogenase (G6PD) and transketolase of pentose phosphate pathway, and overexpression of Nrf2 and knockdown of Keap1 had opposite effects.	Pentosephosphates	173-190	kelch like ECH associated protein 1	Homo sapiens	78-83
30809937-4	2019	Inhibition of Nrf2 and overexpression of Kelch-like ECH-associated protein 1 (Keap1) reduced the expression of glucose-6-phosphate dehydrogenase (G6PD) and transketolase of pentose phosphate pathway, and overexpression of Nrf2 and knockdown of Keap1 had opposite effects.	Pentosephosphates	173-190	glucose-6-phosphate dehydrogenase	Homo sapiens	146-150
30809937-4	2019	Inhibition of Nrf2 and overexpression of Kelch-like ECH-associated protein 1 (Keap1) reduced the expression of glucose-6-phosphate dehydrogenase (G6PD) and transketolase of pentose phosphate pathway, and overexpression of Nrf2 and knockdown of Keap1 had opposite effects.	Pentosephosphates	173-190	NFE2 like bZIP transcription factor 2	Homo sapiens	222-226
30809937-4	2019	Inhibition of Nrf2 and overexpression of Kelch-like ECH-associated protein 1 (Keap1) reduced the expression of glucose-6-phosphate dehydrogenase (G6PD) and transketolase of pentose phosphate pathway, and overexpression of Nrf2 and knockdown of Keap1 had opposite effects.	Pentosephosphates	173-190	kelch like ECH associated protein 1	Homo sapiens	244-249
30875545-1	2019	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway that is essential to maintaining cellular redox balance.	Pentosephosphates	86-103	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
30875545-1	2019	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway that is essential to maintaining cellular redox balance.	Pentosephosphates	86-103	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
30755473-6	2019	Furthermore, promoter-activation assays showed that MYB99 directs precursor supply from the Calvin cycle and oxidative pentose-phosphate pathway in primary metabolism to phenylpropanoid biosynthesis by controlling TRANSKETOLASE2 expression.	Pentosephosphates	119-136	Transketolase	Arabidopsis thaliana	214-228
30987650-1	2019	BACKGROUND: Glucose-6-phospate dehydrogenase (G6PD) is the limiting enzyme of the pentose phosphate pathway (PPP) correlated to cancer progression and drug resistance.	Pentosephosphates	82-99	glucose-6-phosphate dehydrogenase	Homo sapiens	12-44
30798052-1	2019	Phosphoglycerate mutase 1 (PGAM1) coordinates glycolysis, pentose phosphate pathway, and serine synthesis to promote tumor growth through the regulation of its substrate 3-phosphoglycerate (3 PG) and product 2-phosphoglycerate (2 PG).	Pentosephosphates	58-75	phosphoglycerate mutase 1	Homo sapiens	0-25
30798052-1	2019	Phosphoglycerate mutase 1 (PGAM1) coordinates glycolysis, pentose phosphate pathway, and serine synthesis to promote tumor growth through the regulation of its substrate 3-phosphoglycerate (3 PG) and product 2-phosphoglycerate (2 PG).	Pentosephosphates	58-75	phosphoglycerate mutase 1	Homo sapiens	27-32
30987650-1	2019	BACKGROUND: Glucose-6-phospate dehydrogenase (G6PD) is the limiting enzyme of the pentose phosphate pathway (PPP) correlated to cancer progression and drug resistance.	Pentosephosphates	82-99	glucose-6-phosphate dehydrogenase	Homo sapiens	46-50
30659097-6	2019	Employing SH2D5 overexpression or knockdown, we further demonstrate that SH2D5 promotes HCC cell proliferation both in vitro and in vivo While investigating the mechanism of SH2D5-mediated stimulation of HCC cell proliferation, we noted that HBV induces SH2D5 binding to transketolase (TKT), a pentose phosphate pathway enzyme, thereby promoting an interaction between and signal transducer and activator of transcription 3 (STAT3).	Pentosephosphates	294-311	SH2 domain containing 5	Mus musculus	73-78
30659097-6	2019	Employing SH2D5 overexpression or knockdown, we further demonstrate that SH2D5 promotes HCC cell proliferation both in vitro and in vivo While investigating the mechanism of SH2D5-mediated stimulation of HCC cell proliferation, we noted that HBV induces SH2D5 binding to transketolase (TKT), a pentose phosphate pathway enzyme, thereby promoting an interaction between and signal transducer and activator of transcription 3 (STAT3).	Pentosephosphates	294-311	SH2 domain containing 5	Mus musculus	73-78
30659097-6	2019	Employing SH2D5 overexpression or knockdown, we further demonstrate that SH2D5 promotes HCC cell proliferation both in vitro and in vivo While investigating the mechanism of SH2D5-mediated stimulation of HCC cell proliferation, we noted that HBV induces SH2D5 binding to transketolase (TKT), a pentose phosphate pathway enzyme, thereby promoting an interaction between and signal transducer and activator of transcription 3 (STAT3).	Pentosephosphates	294-311	SH2 domain containing 5	Mus musculus	73-78
30661088-3	2019	It was hypothesized that double deficiency of the NADPH-generating enzymes, GSPD-1 (Glucose-6-phosphate 1-dehydrogenase), a functional homolog of human glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, and IDH-1 (isocitrate dehydrogenase-1) affect growth and development in the nematode, Caenorhabditis elegans (C. elegans).	Pentosephosphates	226-243	glucose-6-phosphate dehydrogenase	Homo sapiens	152-185
31016042-1	2019	Background: Glucose-6-phosphate dehydrogenase (G6PD) converts glucose-6-phosphate into 6-phosphogluconate in the pentose phosphate pathway and protects red blood cells (RBCs) from oxidative damage.	Pentosephosphates	113-130	glucose-6-phosphate dehydrogenase	Homo sapiens	12-45
31016042-1	2019	Background: Glucose-6-phosphate dehydrogenase (G6PD) converts glucose-6-phosphate into 6-phosphogluconate in the pentose phosphate pathway and protects red blood cells (RBCs) from oxidative damage.	Pentosephosphates	113-130	glucose-6-phosphate dehydrogenase	Homo sapiens	47-51
30823646-1	2019	The TP53-induced glycolysis and apoptosis regulator (TIGAR) has been shown to decrease glycolysis, to activate the pentose phosphate pathway, and to provide protection against oxidative damage.	Pentosephosphates	115-132	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	4-51
31058257-0	2019	NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism.	Pentosephosphates	34-51	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
31058257-2	2019	Cytosolic NADP is recycled to NADPH by the oxidative pentose phosphate pathway (oxPPP), malic enzyme 1 (ME1) and isocitrate dehydrogenase 1 (IDH1).	Pentosephosphates	53-70	2,4-dienoyl-CoA reductase 1	Homo sapiens	30-35
31058257-2	2019	Cytosolic NADP is recycled to NADPH by the oxidative pentose phosphate pathway (oxPPP), malic enzyme 1 (ME1) and isocitrate dehydrogenase 1 (IDH1).	Pentosephosphates	53-70	malic enzyme 1	Homo sapiens	104-107
30841449-2	2019	In this work, we show that 6-phosphogluconate dehydrogenase (6PGD), a key enzyme of the oxidative pentose phosphate pathway, is important for HCC growth and survival.	Pentosephosphates	98-115	phosphogluconate dehydrogenase	Homo sapiens	27-59
30841449-2	2019	In this work, we show that 6-phosphogluconate dehydrogenase (6PGD), a key enzyme of the oxidative pentose phosphate pathway, is important for HCC growth and survival.	Pentosephosphates	98-115	phosphogluconate dehydrogenase	Homo sapiens	61-65
30823646-1	2019	The TP53-induced glycolysis and apoptosis regulator (TIGAR) has been shown to decrease glycolysis, to activate the pentose phosphate pathway, and to provide protection against oxidative damage.	Pentosephosphates	115-132	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	53-58
30471359-6	2019	We found that the glucose-6-phosphate dehydrogenase enzyme Zwf1, which catalyzes the rate limiting step of pentose phosphate pathway, is required for reducing the accummulation of coniferyl aldehyde-induced ROS, potentially through the sequestering of Zwf1 to sites of ROS accumulation.	Pentosephosphates	107-124	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	18-51
30471359-6	2019	We found that the glucose-6-phosphate dehydrogenase enzyme Zwf1, which catalyzes the rate limiting step of pentose phosphate pathway, is required for reducing the accummulation of coniferyl aldehyde-induced ROS, potentially through the sequestering of Zwf1 to sites of ROS accumulation.	Pentosephosphates	107-124	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	59-63
30471359-6	2019	We found that the glucose-6-phosphate dehydrogenase enzyme Zwf1, which catalyzes the rate limiting step of pentose phosphate pathway, is required for reducing the accummulation of coniferyl aldehyde-induced ROS, potentially through the sequestering of Zwf1 to sites of ROS accumulation.	Pentosephosphates	107-124	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	252-256
30824700-1	2019	6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP).	Pentosephosphates	145-162	phosphogluconate dehydrogenase	Homo sapiens	0-32
30824700-1	2019	6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP).	Pentosephosphates	145-162	phosphogluconate dehydrogenase	Homo sapiens	34-38
30659108-11	2019	Together, our findings suggest that although lack of GLUT1 blunted glycolysis and the pentose phosphate pathway, MPhi were metabolically flexible enough that inflammatory cytokine release was not dramatically regulated, yet phagocytic defects hindered MPhi function in chronic diseases.	Pentosephosphates	86-103	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	53-58
30586497-6	2019	Shinorine production was further improved by modulating the pentose phosphate pathway through deleting TAL1 and overexpressing STB5 and TKL1.	Pentosephosphates	60-77	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1	Saccharomyces cerevisiae S288C	103-107
30586497-6	2019	Shinorine production was further improved by modulating the pentose phosphate pathway through deleting TAL1 and overexpressing STB5 and TKL1.	Pentosephosphates	60-77	Stb5p	Saccharomyces cerevisiae S288C	127-131
30586497-6	2019	Shinorine production was further improved by modulating the pentose phosphate pathway through deleting TAL1 and overexpressing STB5 and TKL1.	Pentosephosphates	60-77	transketolase TKL1	Saccharomyces cerevisiae S288C	136-140
30571714-12	2018	Pathway analysis revealed that PMA affected nicotinate and nicotinamide metabolism, aminoacyl-tRNA biosynthesis and glycolysis, suggesting a redirection of glucose metabolism from glycolysis to the pentose phosphate pathway and production of NADPH for activation of the NADPH oxidase and subsequent respiratory burst.	Pentosephosphates	198-215	2,4-dienoyl-CoA reductase 1	Homo sapiens	242-247
30578080-6	2019	FINDINGS: We found that GPR120 functioned to promote decidualization by upregulating glucose uptake and pentose-phosphate pathway (PPP) of human endometrial stromal cells.	Pentosephosphates	104-121	free fatty acid receptor 4	Homo sapiens	24-30
30266754-9	2019	Proliferation and invasion were adversely affected after HuR suppression and metabolomic studies revealed a reduction in Pentose Phosphate Pathway metabolites, nucleotide precursors, and 2-HG levels.	Pentosephosphates	121-138	ELAV like RNA binding protein 1	Homo sapiens	57-60
30553771-5	2019	MAJOR CONCLUSIONS: PFKFB3 has the highest kinase activity to shunt glucose toward glycolysis, whereas PFKFB4 has more FBPase-2 activity, redirecting glucose toward the pentose phosphate pathway, providing reducing power for lipid biosynthesis and scavenging reactive oxygen species.	Pentosephosphates	168-185	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	19-25
30553771-5	2019	MAJOR CONCLUSIONS: PFKFB3 has the highest kinase activity to shunt glucose toward glycolysis, whereas PFKFB4 has more FBPase-2 activity, redirecting glucose toward the pentose phosphate pathway, providing reducing power for lipid biosynthesis and scavenging reactive oxygen species.	Pentosephosphates	168-185	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Homo sapiens	102-108
30487609-8	2019	Metabolic profiling coupled with unbiased mass spectrometry-based SNO-protein identification revealed that protection by the SNO-CoA-SCoR system is mediated by inhibitory S-nitrosylation of pyruvate kinase M2 (PKM2) through a novel locus of regulation, thereby balancing fuel utilization (through glycolysis) with redox protection (through the pentose phosphate shunt).	Pentosephosphates	344-361	pyruvate kinase, muscle	Mus musculus	190-208
30487609-8	2019	Metabolic profiling coupled with unbiased mass spectrometry-based SNO-protein identification revealed that protection by the SNO-CoA-SCoR system is mediated by inhibitory S-nitrosylation of pyruvate kinase M2 (PKM2) through a novel locus of regulation, thereby balancing fuel utilization (through glycolysis) with redox protection (through the pentose phosphate shunt).	Pentosephosphates	344-361	pyruvate kinase, muscle	Mus musculus	210-214
30190422-6	2018	Importantly, PIM also controls NAD(P)H production by increasing glucose flux through the pentose phosphate shunt decreasing ROS production, and thereby diminishing the cytotoxicity of PI3K-AKT inhibitors.	Pentosephosphates	89-106	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	13-16
30284488-3	2018	TIGAR redirects glycolysis and promotes carcinoma growth by providing metabolic intermediates and reductive power derived from pentose phosphate pathway (PPP).	Pentosephosphates	127-144	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	0-5
30107458-3	2018	Using ChIP-exo, DNA binding targets of Stb5 were found to confirm many previously proposed binding targets, in particular genes encoding enzymes involved in NADPH generation and the pentose-phosphate (PP) pathway.	Pentosephosphates	182-199	Stb5p	Saccharomyces cerevisiae S288C	39-43
30478344-7	2018	In turn, GPI maintains glucose metabolism and energy homeostasis in hypoxia by redirecting the glucose flux from androgen/AR-dependent pentose phosphate pathway (PPP) to hypoxia-induced glycolysis pathway, thereby reducing the growth inhibitory effect of enzalutamide.	Pentosephosphates	135-152	glucose-6-phosphate isomerase	Homo sapiens	9-12
30272333-8	2018	Further molecular study revealed that glucose-6-phosphate dehydrogenase (G6PD), the first and rate-limiting enzyme of the pentose phosphate pathway (PPP), was one of the targets of miR-1.	Pentosephosphates	122-139	glucose-6-phosphate dehydrogenase	Homo sapiens	38-71
30272333-8	2018	Further molecular study revealed that glucose-6-phosphate dehydrogenase (G6PD), the first and rate-limiting enzyme of the pentose phosphate pathway (PPP), was one of the targets of miR-1.	Pentosephosphates	122-139	glucose-6-phosphate dehydrogenase	Homo sapiens	73-77
30272333-8	2018	Further molecular study revealed that glucose-6-phosphate dehydrogenase (G6PD), the first and rate-limiting enzyme of the pentose phosphate pathway (PPP), was one of the targets of miR-1.	Pentosephosphates	122-139	fibronectin type III and SPRY domain containing 1 like	Homo sapiens	181-186
30474881-5	2018	The activity of glucose-6-phosphate dehydrogenase (Zwf1p) and 6-phosphogluconate dehydrogenase (Gnd1p and Gnd2p) is responsible for NADPH formation in a pentose phosphate (PP) pathway.	Pentosephosphates	153-170	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	16-49
30470748-5	2018	KRAS promotes these effects by activating a MAPK-dependent signaling pathway leading to MYC upregulation and transcription of the non-oxidative pentose phosphate pathway (PPP) gene RPIA, which results in nucleotide biosynthesis.	Pentosephosphates	144-161	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
30474881-5	2018	The activity of glucose-6-phosphate dehydrogenase (Zwf1p) and 6-phosphogluconate dehydrogenase (Gnd1p and Gnd2p) is responsible for NADPH formation in a pentose phosphate (PP) pathway.	Pentosephosphates	153-170	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	51-56
30474881-5	2018	The activity of glucose-6-phosphate dehydrogenase (Zwf1p) and 6-phosphogluconate dehydrogenase (Gnd1p and Gnd2p) is responsible for NADPH formation in a pentose phosphate (PP) pathway.	Pentosephosphates	153-170	phosphogluconate dehydrogenase (decarboxylating) GND1	Saccharomyces cerevisiae S288C	96-101
30474881-5	2018	The activity of glucose-6-phosphate dehydrogenase (Zwf1p) and 6-phosphogluconate dehydrogenase (Gnd1p and Gnd2p) is responsible for NADPH formation in a pentose phosphate (PP) pathway.	Pentosephosphates	153-170	phosphogluconate dehydrogenase (decarboxylating) GND2	Saccharomyces cerevisiae S288C	106-111
30470748-5	2018	KRAS promotes these effects by activating a MAPK-dependent signaling pathway leading to MYC upregulation and transcription of the non-oxidative pentose phosphate pathway (PPP) gene RPIA, which results in nucleotide biosynthesis.	Pentosephosphates	144-161	ribose 5-phosphate isomerase A	Homo sapiens	181-185
30323337-3	2018	Here we performed a CRISPR/Cas9-mediated loss-of-function genetic profiling and identified TALDO1, which encodes the rate-limiting transaldolase (TA) enzyme in the non-oxidative pentose phosphate pathway, as essential for cellular survival following pharmacological HER2 blockade.	Pentosephosphates	178-195	transaldolase 1	Homo sapiens	91-97
30405650-1	2018	The xylulose 5-phosphate/phosphate translocator (PTs) (XPT) represents a link between the plastidial and extraplastidial branches of the oxidative pentose phosphate pathway.	Pentosephosphates	147-164	Glucose-6-phosphate/phosphate translocator-like protein	Arabidopsis thaliana	25-47
30323337-3	2018	Here we performed a CRISPR/Cas9-mediated loss-of-function genetic profiling and identified TALDO1, which encodes the rate-limiting transaldolase (TA) enzyme in the non-oxidative pentose phosphate pathway, as essential for cellular survival following pharmacological HER2 blockade.	Pentosephosphates	178-195	transaldolase 1	Homo sapiens	131-144
30323337-3	2018	Here we performed a CRISPR/Cas9-mediated loss-of-function genetic profiling and identified TALDO1, which encodes the rate-limiting transaldolase (TA) enzyme in the non-oxidative pentose phosphate pathway, as essential for cellular survival following pharmacological HER2 blockade.	Pentosephosphates	178-195	transaldolase 1	Homo sapiens	91-93
30323337-3	2018	Here we performed a CRISPR/Cas9-mediated loss-of-function genetic profiling and identified TALDO1, which encodes the rate-limiting transaldolase (TA) enzyme in the non-oxidative pentose phosphate pathway, as essential for cellular survival following pharmacological HER2 blockade.	Pentosephosphates	178-195	erb-b2 receptor tyrosine kinase 2	Homo sapiens	266-270
30119993-9	2018	CONCLUSION: The results obtained in this study suggest that pentose phosphate pathway and its key enzyme TKTL1 is altered throughout the CaP tumorigenesis, and this pathway merits further investigation.	Pentosephosphates	60-77	transketolase like 1	Homo sapiens	105-110
30066842-1	2018	Glucose-6-phosphate dehydrogenase (G6PD) is a rate-limiting enzyme of the pentose phosphate pathway.	Pentosephosphates	74-91	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
30066842-1	2018	Glucose-6-phosphate dehydrogenase (G6PD) is a rate-limiting enzyme of the pentose phosphate pathway.	Pentosephosphates	74-91	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
30019152-0	2018	Metabolic engineering of Pichia pastoris GS115 for enhanced pentose phosphate pathway (PPP) flux toward recombinant human interferon gamma (hIFN-gamma) production.	Pentosephosphates	60-77	interferon gamma	Homo sapiens	122-150
30019152-1	2018	In the present study, the effects of individual as well as multiple genes of pentose phosphate pathway (PPP) on human interferon gamma (hIFN-gamma) production were analyzed.	Pentosephosphates	77-94	interferon gamma	Homo sapiens	118-146
30177747-0	2018	Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells.	Pentosephosphates	44-61	nuclear receptor coactivator 2	Homo sapiens	0-30
30015144-8	2018	Transcriptional analysis also suggested a decrease in both anaerobic glycolysis and pentose phosphate pathway (PPP) in BCB+ COCs, as the anaerobic glycolysis enzymes GAPDH and LDHA and the positive regulator of G6PD activity SIRT2 were upregulated in BCB- cumulus cells.	Pentosephosphates	84-101	L-lactate dehydrogenase A chain	Bos taurus	176-180
30015144-8	2018	Transcriptional analysis also suggested a decrease in both anaerobic glycolysis and pentose phosphate pathway (PPP) in BCB+ COCs, as the anaerobic glycolysis enzymes GAPDH and LDHA and the positive regulator of G6PD activity SIRT2 were upregulated in BCB- cumulus cells.	Pentosephosphates	84-101	glucose-6-phosphate dehydrogenase	Bos taurus	211-215
30015144-8	2018	Transcriptional analysis also suggested a decrease in both anaerobic glycolysis and pentose phosphate pathway (PPP) in BCB+ COCs, as the anaerobic glycolysis enzymes GAPDH and LDHA and the positive regulator of G6PD activity SIRT2 were upregulated in BCB- cumulus cells.	Pentosephosphates	84-101	sirtuin 2	Bos taurus	225-230
30036541-6	2018	We could show that non-differentiating and osteogenic cultivation conditions induced proliferation and showed increasing capacities of the glycolytic marker enzyme phosphofructokinase as well as the marker enzyme of the pentose phosphate pathway glucose-6-phosphate dehydrogenase.	Pentosephosphates	220-237	glucose-6-phosphate dehydrogenase	Homo sapiens	246-279
29885837-1	2018	Transketolase-like 1 (TKTL1) plays an important role in the pentose phosphate pathway (PPP) branch.	Pentosephosphates	60-77	transketolase like 1	Homo sapiens	0-20
29885837-1	2018	Transketolase-like 1 (TKTL1) plays an important role in the pentose phosphate pathway (PPP) branch.	Pentosephosphates	60-77	transketolase like 1	Homo sapiens	22-27
30177747-0	2018	Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells.	Pentosephosphates	44-61	ribose 5-phosphate isomerase A	Homo sapiens	78-82
30177747-6	2018	Importantly, SRC-2 is critical for the normal performance of the pentose phosphate pathway (PPP).	Pentosephosphates	65-82	nuclear receptor coactivator 2	Homo sapiens	13-18
29340974-1	2018	PURPOSE: 6-phosphogluconate dehydrogenase (6PGD), a key enzyme of the oxidative pentose phosphate pathway, is involved in tumor growth and metabolism.	Pentosephosphates	80-97	phosphogluconate dehydrogenase	Homo sapiens	9-41
30060781-3	2018	The levels of enzymes related to glycolysis, lipogenesis, and the pentose phosphate pathway increased in fliI mutants; this result is consistent with the levels of metabolites corresponding to a metabolic pathway.	Pentosephosphates	66-83	flightless I	Drosophila melanogaster	105-109
29340974-1	2018	PURPOSE: 6-phosphogluconate dehydrogenase (6PGD), a key enzyme of the oxidative pentose phosphate pathway, is involved in tumor growth and metabolism.	Pentosephosphates	80-97	phosphogluconate dehydrogenase	Homo sapiens	43-47
30015875-8	2018	Thirdly, SKOV3/DDP cells reset the redox balance by overexpressing the key enzyme glucose 6-phosphate dehydrogenase (G6PD) of the pentose phosphate pathway to eliminate the cytotoxicity of highly elevated ROS.	Pentosephosphates	130-147	translocase of inner mitochondrial membrane 8A	Homo sapiens	15-18
30015875-8	2018	Thirdly, SKOV3/DDP cells reset the redox balance by overexpressing the key enzyme glucose 6-phosphate dehydrogenase (G6PD) of the pentose phosphate pathway to eliminate the cytotoxicity of highly elevated ROS.	Pentosephosphates	130-147	glucose-6-phosphate dehydrogenase	Homo sapiens	82-115
30015875-8	2018	Thirdly, SKOV3/DDP cells reset the redox balance by overexpressing the key enzyme glucose 6-phosphate dehydrogenase (G6PD) of the pentose phosphate pathway to eliminate the cytotoxicity of highly elevated ROS.	Pentosephosphates	130-147	glucose-6-phosphate dehydrogenase	Homo sapiens	117-121
30149622-1	2018	Glucose-6-phosphate dehydrogenase (G6PD) is the first enzyme in the pentose phosphate pathway and is highly relevant in the metabolism of Giardialamblia.	Pentosephosphates	68-85	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
29991649-8	2018	Comparative analysis of U2OS cells expressing either wild-type ATM or the redox sensing-deficient C2991L mutant revealed that one function of ATM redox sensing is to promote glucose flux through the pentose phosphate pathway (PPP) by increasing the abundance and activity of glucose-6-phosphate dehydrogenase (G6PD), thereby increasing cellular antioxidant capacity.	Pentosephosphates	199-216	ATM serine/threonine kinase	Homo sapiens	142-145
29190376-0	2018	p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a.	Pentosephosphates	58-75	tumor protein p53	Homo sapiens	0-3
29190376-0	2018	p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a.	Pentosephosphates	58-75	AKT serine/threonine kinase 1	Homo sapiens	13-16
29921695-0	2018	Transcription Factor YY1 Promotes Cell Proliferation by Directly Activating the Pentose Phosphate Pathway.	Pentosephosphates	80-97	YY1 transcription factor	Homo sapiens	21-24
29921695-4	2018	Here, we show that YY1 alters tumor cell metabolism by activating glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway.	Pentosephosphates	140-157	YY1 transcription factor	Homo sapiens	19-22
29921695-4	2018	Here, we show that YY1 alters tumor cell metabolism by activating glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway.	Pentosephosphates	140-157	glucose-6-phosphate dehydrogenase	Homo sapiens	66-99
29921695-4	2018	Here, we show that YY1 alters tumor cell metabolism by activating glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway.	Pentosephosphates	140-157	glucose-6-phosphate dehydrogenase	Homo sapiens	101-105
29921695-5	2018	By stimulating the pentose phosphate pathway, YY1 enhanced production of nucleotides and DNA synthesis, decreased intracellular reactive oxygen species levels, and promoted antioxidant defense by supplying increased reducing power in the form of NADPH.	Pentosephosphates	19-36	YY1 transcription factor	Homo sapiens	46-49
29921695-5	2018	By stimulating the pentose phosphate pathway, YY1 enhanced production of nucleotides and DNA synthesis, decreased intracellular reactive oxygen species levels, and promoted antioxidant defense by supplying increased reducing power in the form of NADPH.	Pentosephosphates	19-36	2,4-dienoyl-CoA reductase 1	Homo sapiens	246-251
29921695-6	2018	Importantly, YY1-mediated regulation of the pentose phosphate pathway in tumor cells occurred not through p53, but rather through direct activation of G6PD transcription by YY1.	Pentosephosphates	44-61	YY1 transcription factor	Homo sapiens	13-16
29921695-6	2018	Importantly, YY1-mediated regulation of the pentose phosphate pathway in tumor cells occurred not through p53, but rather through direct activation of G6PD transcription by YY1.	Pentosephosphates	44-61	tumor protein p53	Homo sapiens	106-109
29921695-6	2018	Importantly, YY1-mediated regulation of the pentose phosphate pathway in tumor cells occurred not through p53, but rather through direct activation of G6PD transcription by YY1.	Pentosephosphates	44-61	glucose-6-phosphate dehydrogenase	Homo sapiens	151-155
29921695-6	2018	Importantly, YY1-mediated regulation of the pentose phosphate pathway in tumor cells occurred not through p53, but rather through direct activation of G6PD transcription by YY1.	Pentosephosphates	44-61	YY1 transcription factor	Homo sapiens	173-176
29921695-7	2018	Regulation of pentose phosphate pathway activity through G6PD was strongly related to YY1-induced proliferation of tumor cells and tumorigenesis.	Pentosephosphates	14-31	glucose-6-phosphate dehydrogenase	Homo sapiens	57-61
29921695-7	2018	Regulation of pentose phosphate pathway activity through G6PD was strongly related to YY1-induced proliferation of tumor cells and tumorigenesis.	Pentosephosphates	14-31	YY1 transcription factor	Homo sapiens	86-89
29921695-8	2018	Together, our results describe a novel role for YY1 in regulating G6PD in a p53-independent manner, which links its function in tumorigenesis to metabolic reprogramming in tumor cells.Significance: This study reveals a novel role for YY1 in regulating G6PD and activating the pentose phosphate pathway, linking its function in tumorigenesis to metabolic reprogramming.	Pentosephosphates	276-293	YY1 transcription factor	Homo sapiens	48-51
29921695-8	2018	Together, our results describe a novel role for YY1 in regulating G6PD in a p53-independent manner, which links its function in tumorigenesis to metabolic reprogramming in tumor cells.Significance: This study reveals a novel role for YY1 in regulating G6PD and activating the pentose phosphate pathway, linking its function in tumorigenesis to metabolic reprogramming.	Pentosephosphates	276-293	glucose-6-phosphate dehydrogenase	Homo sapiens	66-70
29921695-8	2018	Together, our results describe a novel role for YY1 in regulating G6PD in a p53-independent manner, which links its function in tumorigenesis to metabolic reprogramming in tumor cells.Significance: This study reveals a novel role for YY1 in regulating G6PD and activating the pentose phosphate pathway, linking its function in tumorigenesis to metabolic reprogramming.	Pentosephosphates	276-293	YY1 transcription factor	Homo sapiens	234-237
29991649-8	2018	Comparative analysis of U2OS cells expressing either wild-type ATM or the redox sensing-deficient C2991L mutant revealed that one function of ATM redox sensing is to promote glucose flux through the pentose phosphate pathway (PPP) by increasing the abundance and activity of glucose-6-phosphate dehydrogenase (G6PD), thereby increasing cellular antioxidant capacity.	Pentosephosphates	199-216	glucose-6-phosphate dehydrogenase	Homo sapiens	275-308
29991649-8	2018	Comparative analysis of U2OS cells expressing either wild-type ATM or the redox sensing-deficient C2991L mutant revealed that one function of ATM redox sensing is to promote glucose flux through the pentose phosphate pathway (PPP) by increasing the abundance and activity of glucose-6-phosphate dehydrogenase (G6PD), thereby increasing cellular antioxidant capacity.	Pentosephosphates	199-216	glucose-6-phosphate dehydrogenase	Homo sapiens	310-314
29681509-6	2018	RESULTS: In brain, there are significant regional differences in glucose metabolism, with low levels of hexose bisphosphate (a glycolytic intermediate) and high levels of the pentose phosphate pathway (PPP) enzyme glucose-6-phosphate dehydrogenase (G6PD) and PPP metabolite hexose phosphate in thalamus compared to cortex.	Pentosephosphates	175-192	glucose-6-phosphate dehydrogenase	Homo sapiens	214-247
30044385-1	2018	In several tumor entities, transketolase-like protein 1 (TKTL1) has been suggested to promote the nonoxidative part of the pentose phosphate pathway (PPP) and thereby to contribute to a malignant phenotype.	Pentosephosphates	123-140	transketolase like 1	Homo sapiens	27-55
30044385-1	2018	In several tumor entities, transketolase-like protein 1 (TKTL1) has been suggested to promote the nonoxidative part of the pentose phosphate pathway (PPP) and thereby to contribute to a malignant phenotype.	Pentosephosphates	123-140	transketolase like 1	Homo sapiens	57-62
29904144-4	2018	Glucose-6-phosphate-dehydrogenase (G6PD), the rate-limiting enzyme of the Pentose Phosphate Pathway (PPP), is often activated in human malignancies to generate precursors for nucleotide and lipid synthesis.	Pentosephosphates	74-91	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
30123865-1	2018	Background: Glucose-6-phosphate dehydrogenase (G6PD) is the first enzyme of the pentose phosphate metabolic pathway that supplies reducing agents by maintaining the level of reduced nicotinamide adenine dinucleotide phosphate.	Pentosephosphates	80-97	glucose-6-phosphate dehydrogenase	Homo sapiens	12-45
30123865-1	2018	Background: Glucose-6-phosphate dehydrogenase (G6PD) is the first enzyme of the pentose phosphate metabolic pathway that supplies reducing agents by maintaining the level of reduced nicotinamide adenine dinucleotide phosphate.	Pentosephosphates	80-97	glucose-6-phosphate dehydrogenase	Homo sapiens	47-51
29753331-1	2018	TIGAR is a p53 target gene that is known to protect cells from ROS-induced apoptosis by promoting the pentose phosphate pathway.	Pentosephosphates	102-119	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	0-5
29844386-5	2018	Moreover, the Phf2-mediated activation of the transcription factor NF-E2-related factor 2 (Nrf2) further reroutes glucose fluxes toward the pentose phosphate pathway and glutathione biosynthesis, protecting the liver from oxidative stress and fibrogenesis in response to diet-induced obesity.	Pentosephosphates	140-157	PHD finger protein 2	Homo sapiens	14-18
29844386-5	2018	Moreover, the Phf2-mediated activation of the transcription factor NF-E2-related factor 2 (Nrf2) further reroutes glucose fluxes toward the pentose phosphate pathway and glutathione biosynthesis, protecting the liver from oxidative stress and fibrogenesis in response to diet-induced obesity.	Pentosephosphates	140-157	NFE2 like bZIP transcription factor 2	Homo sapiens	67-89
29844386-5	2018	Moreover, the Phf2-mediated activation of the transcription factor NF-E2-related factor 2 (Nrf2) further reroutes glucose fluxes toward the pentose phosphate pathway and glutathione biosynthesis, protecting the liver from oxidative stress and fibrogenesis in response to diet-induced obesity.	Pentosephosphates	140-157	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
29753331-1	2018	TIGAR is a p53 target gene that is known to protect cells from ROS-induced apoptosis by promoting the pentose phosphate pathway.	Pentosephosphates	102-119	tumor protein p53	Homo sapiens	11-14
29530347-1	2018	Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that dynamically converts 3-phosphoglycerate (3PG) to 2-phosphoglycerate (2PG), which was upregulated to coordinate glycolysis, pentose phosphate pathway (PPP) and serine biosynthesis to promote cancer cell proliferation and tumor growth in a variety of cancers.	Pentosephosphates	185-202	phosphoglycerate mutase 1	Homo sapiens	0-25
29510140-0	2018	Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion.	Pentosephosphates	0-17	heat shock protein family B (small) member 1	Rattus norvegicus	41-46
29510140-0	2018	Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion.	Pentosephosphates	0-17	ATM serine/threonine kinase	Rattus norvegicus	66-69
29510140-2	2018	We previously reported glucose 6-phosphate dehydrogenase (G6PD) activity in pentose phosphate pathway (PPP) is activated via heat shock protein 27 (HSP27) phosphorylation at serine 85 (S85) by ataxia telangiectasia mutated (ATM) kinase during cerebral ischemia.	Pentosephosphates	76-93	glucose-6-phosphate dehydrogenase	Rattus norvegicus	23-56
29510140-2	2018	We previously reported glucose 6-phosphate dehydrogenase (G6PD) activity in pentose phosphate pathway (PPP) is activated via heat shock protein 27 (HSP27) phosphorylation at serine 85 (S85) by ataxia telangiectasia mutated (ATM) kinase during cerebral ischemia.	Pentosephosphates	76-93	glucose-6-phosphate dehydrogenase	Rattus norvegicus	58-62
29510140-2	2018	We previously reported glucose 6-phosphate dehydrogenase (G6PD) activity in pentose phosphate pathway (PPP) is activated via heat shock protein 27 (HSP27) phosphorylation at serine 85 (S85) by ataxia telangiectasia mutated (ATM) kinase during cerebral ischemia.	Pentosephosphates	76-93	heat shock protein family B (small) member 1	Rattus norvegicus	125-146
29510140-2	2018	We previously reported glucose 6-phosphate dehydrogenase (G6PD) activity in pentose phosphate pathway (PPP) is activated via heat shock protein 27 (HSP27) phosphorylation at serine 85 (S85) by ataxia telangiectasia mutated (ATM) kinase during cerebral ischemia.	Pentosephosphates	76-93	heat shock protein family B (small) member 1	Rattus norvegicus	148-153
29510140-2	2018	We previously reported glucose 6-phosphate dehydrogenase (G6PD) activity in pentose phosphate pathway (PPP) is activated via heat shock protein 27 (HSP27) phosphorylation at serine 85 (S85) by ataxia telangiectasia mutated (ATM) kinase during cerebral ischemia.	Pentosephosphates	76-93	ATM serine/threonine kinase	Rattus norvegicus	224-227
29530347-1	2018	Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that dynamically converts 3-phosphoglycerate (3PG) to 2-phosphoglycerate (2PG), which was upregulated to coordinate glycolysis, pentose phosphate pathway (PPP) and serine biosynthesis to promote cancer cell proliferation and tumor growth in a variety of cancers.	Pentosephosphates	185-202	phosphoglycerate mutase 1	Homo sapiens	27-32
29621349-5	2018	The highly activated transketolase and transaldolase genes TKL1, TKL2, TAL1 and NQM1 as well as their complex interactions in the non-oxidative pentose phosphate pathway branch were critical for the serial of sugar transformation to drive the metabolic flow into glycolysis for increased ethanol production.	Pentosephosphates	144-161	transketolase TKL1	Saccharomyces cerevisiae S288C	59-63
29760380-0	2018	A new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo.	Pentosephosphates	60-77	glucose-6-phosphate dehydrogenase	Homo sapiens	19-52
29291545-5	2018	The contribution of pentose phosphate pathway (PPP) and its related redox status were checked by chemical interfering and silencing/over-expression of glucose-6-phosphate dehydrogenase (G6PD).	Pentosephosphates	20-37	glucose-6-phosphate dehydrogenase	Homo sapiens	151-184
29291545-5	2018	The contribution of pentose phosphate pathway (PPP) and its related redox status were checked by chemical interfering and silencing/over-expression of glucose-6-phosphate dehydrogenase (G6PD).	Pentosephosphates	20-37	glucose-6-phosphate dehydrogenase	Homo sapiens	186-190
29507094-4	2018	To determine the impact of these changes on the cellular functions following, we analyzed how KLF4 alters glioblastoma cell metabolism, including glucose uptake, glycolysis, pentose phosphate pathway, and oxidative phosphorylation.	Pentosephosphates	174-191	Kruppel like factor 4	Homo sapiens	94-98
29621349-5	2018	The highly activated transketolase and transaldolase genes TKL1, TKL2, TAL1 and NQM1 as well as their complex interactions in the non-oxidative pentose phosphate pathway branch were critical for the serial of sugar transformation to drive the metabolic flow into glycolysis for increased ethanol production.	Pentosephosphates	144-161	transketolase TKL2	Saccharomyces cerevisiae S288C	65-69
29621349-5	2018	The highly activated transketolase and transaldolase genes TKL1, TKL2, TAL1 and NQM1 as well as their complex interactions in the non-oxidative pentose phosphate pathway branch were critical for the serial of sugar transformation to drive the metabolic flow into glycolysis for increased ethanol production.	Pentosephosphates	144-161	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1	Saccharomyces cerevisiae S288C	71-75
29621349-5	2018	The highly activated transketolase and transaldolase genes TKL1, TKL2, TAL1 and NQM1 as well as their complex interactions in the non-oxidative pentose phosphate pathway branch were critical for the serial of sugar transformation to drive the metabolic flow into glycolysis for increased ethanol production.	Pentosephosphates	144-161	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1	Saccharomyces cerevisiae S288C	80-84
29500232-5	2018	BLVRB-deficient embryoid body formation (a critical size parameter of early lineage fate potential) demonstrated enhanced sensitivity to the pentose phosphate pathway (PPP) inhibitor 6-aminonicotinamide with no differences in the glycolytic pathway inhibitor 2-deoxyglucose.	Pentosephosphates	141-158	biliverdin reductase B	Homo sapiens	0-5
29501744-0	2018	LncRNA PDIA3P interacts with c-Myc to regulate cell proliferation via induction of pentose phosphate pathway in multiple myeloma.	Pentosephosphates	83-100	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	29-34
29615789-7	2018	Functionally, PFKFB4-driven SRC-3 activation drives glucose flux towards the pentose phosphate pathway and enables purine synthesis by transcriptionally upregulating the expression of the enzyme transketolase.	Pentosephosphates	77-94	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Homo sapiens	14-20
29615789-7	2018	Functionally, PFKFB4-driven SRC-3 activation drives glucose flux towards the pentose phosphate pathway and enables purine synthesis by transcriptionally upregulating the expression of the enzyme transketolase.	Pentosephosphates	77-94	nuclear receptor coactivator 3	Homo sapiens	28-33
28950391-1	2018	AIM: Pentose phosphate pathway (PPP) with key enzyme transketolase (TKT), represents a potentially "protective" mechanism in hyperglycaemia.	Pentosephosphates	5-22	transketolase	Homo sapiens	53-66
28950391-1	2018	AIM: Pentose phosphate pathway (PPP) with key enzyme transketolase (TKT), represents a potentially "protective" mechanism in hyperglycaemia.	Pentosephosphates	5-22	transketolase	Homo sapiens	68-71
29579121-7	2018	Using capillary electrophoresis-time-of-flight mass spectrometry (CE-TOF/MS) analysis, hst3  hst4  sir2  fbp1  cells accumulated not only glycolytic metabolites but also secondary metabolites, including nucleotides that were synthesized throughout the pentose phosphate (PP) pathway, although various amino acids remained at low levels.	Pentosephosphates	252-269	NAD-dependent histone deacetylase HST3	Saccharomyces cerevisiae S288C	87-91
29579121-7	2018	Using capillary electrophoresis-time-of-flight mass spectrometry (CE-TOF/MS) analysis, hst3  hst4  sir2  fbp1  cells accumulated not only glycolytic metabolites but also secondary metabolites, including nucleotides that were synthesized throughout the pentose phosphate (PP) pathway, although various amino acids remained at low levels.	Pentosephosphates	252-269	NAD-dependent histone deacetylase HST4	Saccharomyces cerevisiae S288C	93-97
29579121-7	2018	Using capillary electrophoresis-time-of-flight mass spectrometry (CE-TOF/MS) analysis, hst3  hst4  sir2  fbp1  cells accumulated not only glycolytic metabolites but also secondary metabolites, including nucleotides that were synthesized throughout the pentose phosphate (PP) pathway, although various amino acids remained at low levels.	Pentosephosphates	252-269	fructose 1,6-bisphosphate 1-phosphatase	Saccharomyces cerevisiae S288C	105-109
29431732-6	2018	Upregulation of p53 in turn disrupted the pentose phosphate pathway, leading to excessive ROS production and dormant TRC death.	Pentosephosphates	42-59	tumor protein p53	Homo sapiens	16-19
29331305-2	2018	We previously demonstrated a protective role of TP53-induced glycolysis and apoptosis regulator (TIGAR) in ischemic neuronal injury through increasing the flow of pentose phosphate pathway (PPP).	Pentosephosphates	163-180	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	48-95
29331305-2	2018	We previously demonstrated a protective role of TP53-induced glycolysis and apoptosis regulator (TIGAR) in ischemic neuronal injury through increasing the flow of pentose phosphate pathway (PPP).	Pentosephosphates	163-180	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	97-102
28707979-5	2018	Recent Advances: New work has begun to elucidate the roles of SIRT5 in glycolysis, tricarboxylic acid cycle, fatty acid oxidation, nitrogen metabolism, pentose phosphate pathway, antioxidant defense, and apoptosis.	Pentosephosphates	152-169	sirtuin 5	Homo sapiens	62-67
29445082-2	2018	Its role in tumor metabolism is not definitively established, but investigators have suggested that regulation of PKM2 activity can cause accumulation of glycolytic intermediates and increase flux through the pentose phosphate pathway.	Pentosephosphates	209-226	pyruvate kinase, muscle	Mus musculus	114-118
29487283-9	2018	Besides, BRAFi-resistant melanoma exhibits a strong activation of NRF-2 pathway leading to increase in the pentose phosphate pathway, which is involved in the regeneration of reduced glutathione, and to increase in xCT expression, a component of the xc-amino acid transporter essential for the uptake of cystine required for intracellular glutathione synthesis.	Pentosephosphates	107-124	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-71
29317613-1	2018	Glucose-6-phosphate dehydrogenase (G6PD) is a housekeeping enzyme involved in the pentose phosphate shunt for producing nicotinamide adenine dinucleotide phosphate (NADPH).	Pentosephosphates	82-99	glucose-6-phosphate dehydrogenase	Danio rerio	0-33
29531803-6	2018	Within these gene networks, glucose-6-phosphate dehydrogenase (G6PD), the first and rate-limiting enzyme (producing NADPH) in pentose phosphate pathway, emerged as the critical node regulating cellular effects of H2S.	Pentosephosphates	126-143	glucose-6-phosphate dehydrogenase	Homo sapiens	28-61
29531803-6	2018	Within these gene networks, glucose-6-phosphate dehydrogenase (G6PD), the first and rate-limiting enzyme (producing NADPH) in pentose phosphate pathway, emerged as the critical node regulating cellular effects of H2S.	Pentosephosphates	126-143	glucose-6-phosphate dehydrogenase	Homo sapiens	63-67
29337987-2	2018	Deregulation of ribose-5-phosphate isomerase A (RPIA) in the pentose phosphate pathway (PPP) is known to promote tumorigenesis in liver, lung, and breast tissues.	Pentosephosphates	61-78	ribose 5-phosphate isomerase A	Homo sapiens	16-46
29337987-2	2018	Deregulation of ribose-5-phosphate isomerase A (RPIA) in the pentose phosphate pathway (PPP) is known to promote tumorigenesis in liver, lung, and breast tissues.	Pentosephosphates	61-78	ribose 5-phosphate isomerase A	Homo sapiens	48-52
29119686-5	2018	Metabolomic analysis showed that the antioxidant pentose phosphate pathway and its limiting enzyme, glucose-6-phosphate dehydrogenase (G6PD), were concomitantly preserved.	Pentosephosphates	49-66	glucose-6-phosphate dehydrogenase	Homo sapiens	100-133
29119686-5	2018	Metabolomic analysis showed that the antioxidant pentose phosphate pathway and its limiting enzyme, glucose-6-phosphate dehydrogenase (G6PD), were concomitantly preserved.	Pentosephosphates	49-66	glucose-6-phosphate dehydrogenase	Homo sapiens	135-139
28775155-6	2018	Peroxisomes possess several NADPH regeneration mechanisms, such as those mediated by glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) proteins, which are involved in the oxidative phase of the pentose phosphate pathway, as well as that mediated by NADP-isocitrate dehydrogenase (ICDH).	Pentosephosphates	231-248	2,4-dienoyl-CoA reductase 1	Homo sapiens	28-33
28775155-6	2018	Peroxisomes possess several NADPH regeneration mechanisms, such as those mediated by glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) proteins, which are involved in the oxidative phase of the pentose phosphate pathway, as well as that mediated by NADP-isocitrate dehydrogenase (ICDH).	Pentosephosphates	231-248	glucose-6-phosphate dehydrogenase	Homo sapiens	85-118
28775155-6	2018	Peroxisomes possess several NADPH regeneration mechanisms, such as those mediated by glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) proteins, which are involved in the oxidative phase of the pentose phosphate pathway, as well as that mediated by NADP-isocitrate dehydrogenase (ICDH).	Pentosephosphates	231-248	glucose-6-phosphate dehydrogenase	Homo sapiens	120-125
29287724-1	2018	Our previous study found that PARIS (ZNF746) transcriptionally suppressed transketolase (TKT), a key enzyme in pentose phosphate pathway (PPP) in the substantia nigra (SN) of AAV-PARIS injected mice.	Pentosephosphates	111-128	zinc finger protein 746	Homo sapiens	30-35
29287724-1	2018	Our previous study found that PARIS (ZNF746) transcriptionally suppressed transketolase (TKT), a key enzyme in pentose phosphate pathway (PPP) in the substantia nigra (SN) of AAV-PARIS injected mice.	Pentosephosphates	111-128	zinc finger protein 746	Mus musculus	37-43
29287724-1	2018	Our previous study found that PARIS (ZNF746) transcriptionally suppressed transketolase (TKT), a key enzyme in pentose phosphate pathway (PPP) in the substantia nigra (SN) of AAV-PARIS injected mice.	Pentosephosphates	111-128	transketolase	Mus musculus	74-87
29287724-1	2018	Our previous study found that PARIS (ZNF746) transcriptionally suppressed transketolase (TKT), a key enzyme in pentose phosphate pathway (PPP) in the substantia nigra (SN) of AAV-PARIS injected mice.	Pentosephosphates	111-128	transketolase	Mus musculus	89-92
29317613-1	2018	Glucose-6-phosphate dehydrogenase (G6PD) is a housekeeping enzyme involved in the pentose phosphate shunt for producing nicotinamide adenine dinucleotide phosphate (NADPH).	Pentosephosphates	82-99	glucose-6-phosphate dehydrogenase	Danio rerio	35-39
29153923-4	2018	RESULTS: Unexpectedly, metabolomic analyses demonstrated that Mox heavily rely on glucose metabolism and the pentose phosphate pathway (PPP) to support GSH production and Nrf2-dependent antioxidant gene expression.	Pentosephosphates	109-126	monooxygenase DBH like 1	Homo sapiens	62-65
29493303-1	2018	Glucose-6-phosphate dehydrogenase (G6PD) is an essential enzyme in the pentose phosphate pathway that prevents oxidative damage to cells.	Pentosephosphates	71-88	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
29493303-1	2018	Glucose-6-phosphate dehydrogenase (G6PD) is an essential enzyme in the pentose phosphate pathway that prevents oxidative damage to cells.	Pentosephosphates	71-88	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
29153923-4	2018	RESULTS: Unexpectedly, metabolomic analyses demonstrated that Mox heavily rely on glucose metabolism and the pentose phosphate pathway (PPP) to support GSH production and Nrf2-dependent antioxidant gene expression.	Pentosephosphates	109-126	NFE2 like bZIP transcription factor 2	Homo sapiens	171-175
29191950-5	2017	TGF-beta/FBS-stimulated COPD ASMCs showed restoration of fatty acid oxidation capacity, upregulation of the pentose phosphate pathway product ribose-5-phosphate and of nucleotide biosynthesis intermediates, and increased levels of the glutamine catabolite glutamate.	Pentosephosphates	108-125	transforming growth factor beta 1	Homo sapiens	0-8
29169374-0	2017	ID1 promotes hepatocellular carcinoma proliferation and confers chemoresistance to oxaliplatin by activating pentose phosphate pathway.	Pentosephosphates	109-126	inhibitor of DNA binding 1, HLH protein	Homo sapiens	0-3
29169374-2	2017	The aim of the present study was to determine whether aberrant high expression of the inhibitor of differentiation 1(ID1) confers oxaliplatin-resistance to HCC by activating the pentose phosphate pathway (PPP).	Pentosephosphates	178-195	inhibitor of DNA binding 1, HLH protein	Homo sapiens	117-120
28969371-9	2017	Mechanistically, mTORC1 upregulated the first and rate limiting enzyme of the pentose phosphate pathway, G6PD.	Pentosephosphates	78-95	CREB regulated transcription coactivator 1	Mus musculus	17-23
28939041-4	2017	Herein, we find that the protein and mRNA of transketolase (TKT), a key enzyme in pentose phosphate pathway (PPP) of glucose metabolism, is exclusively decreased in the SN of AAV-PARIS mice.	Pentosephosphates	82-99	transketolase	Mus musculus	45-58
28939041-4	2017	Herein, we find that the protein and mRNA of transketolase (TKT), a key enzyme in pentose phosphate pathway (PPP) of glucose metabolism, is exclusively decreased in the SN of AAV-PARIS mice.	Pentosephosphates	82-99	transketolase	Mus musculus	60-63
28807815-0	2017	Bcl-xL knockout attenuates mitochondrial respiration and causes oxidative stress that is compensated by pentose phosphate pathway activity.	Pentosephosphates	104-121	BCL2-like 1	Mus musculus	0-6
28823591-0	2017	G6PD plays a neuroprotective role in brain ischemia through promoting pentose phosphate pathway.	Pentosephosphates	70-87	glucose-6-phosphate dehydrogenase 2	Mus musculus	0-4
28823591-1	2017	TIGAR-regulated pentose phosphate pathway (PPP) plays a critical role in the neuronal survival during cerebral ischemia/reperfusion.	Pentosephosphates	16-33	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	0-5
28888161-8	2017	We suggest that the NADPH provided by the oxidative phase of the pentose phosphate pathway (OxPPP) should serve to maintain glutathione reductase (GR) activity, thus preserving and regenerating the intracellular GSH pool under glyphosate-induced stress.	Pentosephosphates	65-82	glutathione reductase	Arabidopsis thaliana	124-145
28888161-8	2017	We suggest that the NADPH provided by the oxidative phase of the pentose phosphate pathway (OxPPP) should serve to maintain glutathione reductase (GR) activity, thus preserving and regenerating the intracellular GSH pool under glyphosate-induced stress.	Pentosephosphates	65-82	glutathione reductase	Arabidopsis thaliana	147-149
29138396-0	2017	Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway.	Pentosephosphates	97-114	polo like kinase 1	Homo sapiens	0-18
29138396-2	2017	Here we identify that Polo-like kinase 1 (Plk1), a key regulator for cell mitosis, plays a critical role for biosynthesis in cancer cells through activating pentose phosphate pathway (PPP).	Pentosephosphates	157-174	polo like kinase 1	Homo sapiens	22-40
29138396-2	2017	Here we identify that Polo-like kinase 1 (Plk1), a key regulator for cell mitosis, plays a critical role for biosynthesis in cancer cells through activating pentose phosphate pathway (PPP).	Pentosephosphates	157-174	polo like kinase 1	Homo sapiens	42-46
28280275-5	2017	Metabolic analysis identified the pentose phosphate pathway (PPP) as an important pro-survival pathway for glucose metabolism in AML cells with high mTORC1 activity and provided a clear rational for targeting glucose-6-phosphate dehydrogenase (G6PD) in AML.	Pentosephosphates	34-51	CREB regulated transcription coactivator 1	Mus musculus	149-155
28280275-5	2017	Metabolic analysis identified the pentose phosphate pathway (PPP) as an important pro-survival pathway for glucose metabolism in AML cells with high mTORC1 activity and provided a clear rational for targeting glucose-6-phosphate dehydrogenase (G6PD) in AML.	Pentosephosphates	34-51	glucose-6-phosphate dehydrogenase	Homo sapiens	209-242
28280275-5	2017	Metabolic analysis identified the pentose phosphate pathway (PPP) as an important pro-survival pathway for glucose metabolism in AML cells with high mTORC1 activity and provided a clear rational for targeting glucose-6-phosphate dehydrogenase (G6PD) in AML.	Pentosephosphates	34-51	glucose-6-phosphate dehydrogenase	Homo sapiens	244-248
28969371-9	2017	Mechanistically, mTORC1 upregulated the first and rate limiting enzyme of the pentose phosphate pathway, G6PD.	Pentosephosphates	78-95	glucose-6-phosphate dehydrogenase	Homo sapiens	105-109
30258923-1	2017	Glucose 6 phosphate dehydrogenase (G6PD) is a key and rate limiting enzyme in the pentose phosphate pathway (PPP).	Pentosephosphates	82-99	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
28720669-4	2017	We also investigated whether inhibition of glycolysis could revert MUC1-mediated metabolic alterations and radiation resistance by using in vitro and in vivo models.Results: MUC1 expression diminished radiation-induced cytotoxicity and DNA damage in pancreatic cancer cells by enhancing glycolysis, pentose phosphate pathway, and nucleotide biosynthesis.	Pentosephosphates	299-316	mucin 1, cell surface associated	Homo sapiens	174-178
28865321-3	2017	In this context, the ribose 5-phosphate isomerase (Rpi) enzyme is a potential drug target mainly due to its function in the pentose phosphate pathway and its essentiality (previously shown in other trypanosomatids).	Pentosephosphates	124-141	ribose 5-phosphate isomerase A	Homo sapiens	51-54
30258923-1	2017	Glucose 6 phosphate dehydrogenase (G6PD) is a key and rate limiting enzyme in the pentose phosphate pathway (PPP).	Pentosephosphates	82-99	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
28557068-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is the first enzyme on which the pentose phosphate pathway was checked.	Pentosephosphates	74-91	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-33
29245936-6	2017	Strikingly, enforced expression of PCLP1 enhances lipid droplet formation as well as pentose phosphate pathway and glutamine dependence, indicative of metabolic reprogramming necessary to support the abnormal proliferation rate of tumor cells.	Pentosephosphates	85-102	podocalyxin like	Homo sapiens	35-40
28655791-5	2017	Following DEN treatment, Nrf2 genetic disruption reduced expression of pentose phosphate pathway-related enzymes, the depletion of which has been associated with an amelioration of HCC incidence.	Pentosephosphates	71-88	nuclear factor, erythroid derived 2, like 2	Mus musculus	25-29
28709868-5	2017	Comparing with in p53 knockdown NP cells, relative high p53 expression in normal control NP cells inhibited autophagy and the pentose phosphate pathway.	Pentosephosphates	126-143	tumor protein p53	Homo sapiens	56-59
28557068-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is the first enzyme on which the pentose phosphate pathway was checked.	Pentosephosphates	74-91	glucose-6-phosphate dehydrogenase	Rattus norvegicus	35-39
28450085-0	2017	Corrigendum to "Combined metabolic and transcriptional profiling identifies pentose phosphate pathway activation by HSP27 phosphorylation during cerebral ischemia" [Neuroscience 349 (2017) 1-16].	Pentosephosphates	76-93	heat shock protein family B (small) member 1	Homo sapiens	116-121
28535465-6	2017	Additionally, the activity of glucose-6-phosphate dehydrogenase (G6PDH) was markedly increased at 1.90 mg/L, which might result in the activation of the pentose phosphate pathway.	Pentosephosphates	153-170	glucose-6-phosphate dehydrogenase	Danio rerio	30-63
28535465-6	2017	Additionally, the activity of glucose-6-phosphate dehydrogenase (G6PDH) was markedly increased at 1.90 mg/L, which might result in the activation of the pentose phosphate pathway.	Pentosephosphates	153-170	glucose-6-phosphate dehydrogenase	Danio rerio	65-70
28852166-5	2017	Model simulations also reveal that pentose phosphate pathway and oxidative phosphorylation activities were kept at minimal levels to ensure NADPH production and anabolic precursors synthesis.	Pentosephosphates	35-52	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	140-145
28627690-1	2017	Human glucose-6-phosphate dehydrogenase (G6PD) is a crucial enzyme in the pentose phosphate pathway, and serves an important role in biosynthesis and the redox balance.	Pentosephosphates	74-91	glucose-6-phosphate dehydrogenase	Homo sapiens	6-39
28627690-1	2017	Human glucose-6-phosphate dehydrogenase (G6PD) is a crucial enzyme in the pentose phosphate pathway, and serves an important role in biosynthesis and the redox balance.	Pentosephosphates	74-91	glucose-6-phosphate dehydrogenase	Homo sapiens	41-45
28477473-6	2017	By detecting the activation of glucose-6-phosphate dehydrogenase (G6PD), we confirmed that IRG1 could increase ROS level by promoting pentose phosphate pathway (PPP).	Pentosephosphates	134-151	aconitate decarboxylase 1	Homo sapiens	91-95
28761052-5	2017	UCHL1 overexpression induced the reprogramming of carbohydrate metabolism and increased NADPH levels in a pentose phosphate pathway (PPP)-dependent manner.	Pentosephosphates	106-123	ubiquitin carboxy-terminal hydrolase L1	Mus musculus	0-5
27324791-10	2017	Overexpression of wild type or A53T mutant alpha-synuclein stimulated glucose accumulation and PQ toxicity, and this toxic synergism was reduced by inhibition of glucose metabolism/transport and the pentose phosphate pathway (6-aminonicotinamide).	Pentosephosphates	199-216	synuclein alpha	Homo sapiens	43-58
28713273-4	2017	In this study, we demonstrated that the oxidative pentose phosphate pathway enzyme 6-phosphogluconate dehydrogenase (6PGD) promotes cisplatin resistance.	Pentosephosphates	50-67	phosphogluconate dehydrogenase	Homo sapiens	83-115
28625755-7	2017	Further examination elucidated the diverged impacts of disrupting the oxidative branch (ZWF1) of the pentose phosphate pathway on the titers of desired products belonging to different portions of the pathway.	Pentosephosphates	101-118	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	88-92
28978059-4	2017	We also found that inhibiting NADPH production through knockdown of 6-phosphogluconate dehydrogenase (6PGD) within the pentose phosphate pathway was sufficient to reduce cell growth and lactate production, a measure of metabolic reprogramming.	Pentosephosphates	119-136	2,4-dienoyl-CoA reductase 1	Homo sapiens	30-35
28978059-4	2017	We also found that inhibiting NADPH production through knockdown of 6-phosphogluconate dehydrogenase (6PGD) within the pentose phosphate pathway was sufficient to reduce cell growth and lactate production, a measure of metabolic reprogramming.	Pentosephosphates	119-136	phosphogluconate dehydrogenase	Homo sapiens	68-100
28978059-4	2017	We also found that inhibiting NADPH production through knockdown of 6-phosphogluconate dehydrogenase (6PGD) within the pentose phosphate pathway was sufficient to reduce cell growth and lactate production, a measure of metabolic reprogramming.	Pentosephosphates	119-136	phosphogluconate dehydrogenase	Homo sapiens	102-106
28713273-4	2017	In this study, we demonstrated that the oxidative pentose phosphate pathway enzyme 6-phosphogluconate dehydrogenase (6PGD) promotes cisplatin resistance.	Pentosephosphates	50-67	phosphogluconate dehydrogenase	Homo sapiens	117-121
28596515-10	2017	G6pd, a vital enzyme in pentose phosphate pathway, is highly expressed in Ymac-1.	Pentosephosphates	24-41	glucose-6-phosphate dehydrogenase 2	Mus musculus	0-4
28473643-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	Pentosephosphates	86-103	glucose-6-phosphate dehydrogenase 2	Mus musculus	0-33
28473643-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	Pentosephosphates	86-103	glucose-6-phosphate dehydrogenase 2	Mus musculus	35-39
28473643-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	Pentosephosphates	86-103	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	199-204
28473643-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	Pentosephosphates	86-103	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	250-255
28473643-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	Pentosephosphates	86-103	thioredoxin 1	Mus musculus	290-301
28473643-10	2017	Under G6pd deficiency conditions, isocitrate dehydrogenase 1 likely functions as the principal source of NADPH for cytosolic antioxidant defense in the cochlea.SIGNIFICANCE STATEMENT Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	Pentosephosphates	269-286	glucose-6-phosphate dehydrogenase 2	Mus musculus	6-10
28473643-10	2017	Under G6pd deficiency conditions, isocitrate dehydrogenase 1 likely functions as the principal source of NADPH for cytosolic antioxidant defense in the cochlea.SIGNIFICANCE STATEMENT Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	Pentosephosphates	269-286	glucose-6-phosphate dehydrogenase 2	Mus musculus	183-216
28157187-4	2017	High 13C recovery from C-1 in CO2 indicates that glucose was predominantly metabolized via the pentose phosphate pathway irrespective of inhibition.	Pentosephosphates	95-112	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	23-26
28542136-5	2017	Mechanistically, PAK4 interacted with glucose-6-phosphate dehydrogenase (G6PD), a rate-limiting enzyme of the pentose phosphate pathway and increased G6PD activity via enhancing Mdm2-mediated p53 ubiquitination degradation.	Pentosephosphates	110-127	p21 (RAC1) activated kinase 4	Homo sapiens	17-21
28611670-2	2017	Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly coordinates glycolysis, pentose phosphate pathway (PPP) flux and serine biosynthesis in cancer cells and hence gains increasing interest of inhibitor discovery.	Pentosephosphates	98-115	phosphoglycerate mutase 1	Homo sapiens	0-25
28611670-2	2017	Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly coordinates glycolysis, pentose phosphate pathway (PPP) flux and serine biosynthesis in cancer cells and hence gains increasing interest of inhibitor discovery.	Pentosephosphates	98-115	phosphoglycerate mutase 1	Homo sapiens	27-32
28235541-4	2017	Ingenuity Pathway Analysis (IPA) identified that 1) glycolysis and the pentose phosphate pathway are major canonical pathways associated with PLK1, and 2) PLK1 inhibition-modulated genes were largely associated with cellular proliferation, with FBP1 being the key modulator.	Pentosephosphates	71-88	polo like kinase 1	Homo sapiens	142-146
28235541-4	2017	Ingenuity Pathway Analysis (IPA) identified that 1) glycolysis and the pentose phosphate pathway are major canonical pathways associated with PLK1, and 2) PLK1 inhibition-modulated genes were largely associated with cellular proliferation, with FBP1 being the key modulator.	Pentosephosphates	71-88	polo like kinase 1	Homo sapiens	155-159
28235541-4	2017	Ingenuity Pathway Analysis (IPA) identified that 1) glycolysis and the pentose phosphate pathway are major canonical pathways associated with PLK1, and 2) PLK1 inhibition-modulated genes were largely associated with cellular proliferation, with FBP1 being the key modulator.	Pentosephosphates	71-88	fructose-bisphosphatase 1	Homo sapiens	245-249
28542136-5	2017	Mechanistically, PAK4 interacted with glucose-6-phosphate dehydrogenase (G6PD), a rate-limiting enzyme of the pentose phosphate pathway and increased G6PD activity via enhancing Mdm2-mediated p53 ubiquitination degradation.	Pentosephosphates	110-127	glucose-6-phosphate dehydrogenase	Homo sapiens	38-71
28542136-5	2017	Mechanistically, PAK4 interacted with glucose-6-phosphate dehydrogenase (G6PD), a rate-limiting enzyme of the pentose phosphate pathway and increased G6PD activity via enhancing Mdm2-mediated p53 ubiquitination degradation.	Pentosephosphates	110-127	glucose-6-phosphate dehydrogenase	Homo sapiens	73-77
28535765-1	2017	BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) is a rate limiting enzyme of the pentose phosphate pathway and is closely associated with the haemolytic disorders among patients receiving anti-malarial drugs, such as primaquine.	Pentosephosphates	86-103	glucose-6-phosphate dehydrogenase	Homo sapiens	12-45
28535765-1	2017	BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) is a rate limiting enzyme of the pentose phosphate pathway and is closely associated with the haemolytic disorders among patients receiving anti-malarial drugs, such as primaquine.	Pentosephosphates	86-103	glucose-6-phosphate dehydrogenase	Homo sapiens	47-51
28481367-5	2017	These results suggest that in a low-glucose environment, where glycolysis and the pentose phosphate pathway (PPP) is attenuated, cancer cells become dependent on ME1 for the supply of NADPH and pyruvate.	Pentosephosphates	82-99	malic enzyme 1	Homo sapiens	162-165
28032668-4	2017	Transketolase diverts excess glycolytic metabolites from the hexosamine, protein kinase C, and advanced glycation endproduct pathways to the pentose phosphate pathway, with a protective effect against hyperglycaemia-induced damage.	Pentosephosphates	141-158	transketolase	Homo sapiens	0-13
28257891-0	2017	Combined metabolic and transcriptional profiling identifies pentose phosphate pathway activation by HSP27 phosphorylation during cerebral ischemia.	Pentosephosphates	60-77	heat shock protein family B (small) member 1	Rattus norvegicus	100-105
28303926-7	2017	Our results showed that MDR (P-gp overexpressing) cells have a different metabolic profile from their drug-sensitive counterparts, demonstrating decreases in the pentose phosphate pathway and oxidative phosphorylation rate; increases in glutathione metabolism and glycolysis; and alterations in the methionine/S-adenosylmethionine pathway.	Pentosephosphates	162-179	ATP binding cassette subfamily B member 1	Homo sapiens	29-33
27103086-2	2017	We hypothesized that genetic variability in the gene encoding transketolase, a key pentose phosphate pathway enzyme, contributes to early nerve dysfunction in recent-onset diabetes.	Pentosephosphates	83-100	transketolase	Homo sapiens	62-75
28384067-1	2017	Tp53-induced glycolysis and apoptosis regulator (TIGAR) enhances the pentose phosphate pathway, thereby contributing directly to DNA repair due to generation of nicotinamide adenine dinucleotide phosphate (NADPH) and ribose-5-phosphate, two key precursors of DNA synthesis and repair.	Pentosephosphates	69-86	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	0-47
28384067-1	2017	Tp53-induced glycolysis and apoptosis regulator (TIGAR) enhances the pentose phosphate pathway, thereby contributing directly to DNA repair due to generation of nicotinamide adenine dinucleotide phosphate (NADPH) and ribose-5-phosphate, two key precursors of DNA synthesis and repair.	Pentosephosphates	69-86	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	49-54
28355222-3	2017	Previously, we determined that decreased expression of the cytosolic pentose phosphate pathway (PPP) enzyme transaldolase activates the mitochondrial unfolded protein response (UPRmt) and extends lifespan.	Pentosephosphates	69-86	Transaldolase	Caenorhabditis elegans	108-121
28352301-6	2017	RESULTS: In this study, we functionally overexpressed four genes involved in the pentose phosphate pathway (PPP): gene YALI0E06479g encoding transketolase (TKL1), gene YALI0F15587g encoding transaldolase (TAL1), gene YALI0E22649g encoding glucose-6-phosphate dehydrogenase (ZWF1), and gene YALI0B15598g encoding 6-phosphogluconate dehydrogenase (GND1).	Pentosephosphates	81-98	transketolase TKL1	Saccharomyces cerevisiae S288C	156-160
28352301-6	2017	RESULTS: In this study, we functionally overexpressed four genes involved in the pentose phosphate pathway (PPP): gene YALI0E06479g encoding transketolase (TKL1), gene YALI0F15587g encoding transaldolase (TAL1), gene YALI0E22649g encoding glucose-6-phosphate dehydrogenase (ZWF1), and gene YALI0B15598g encoding 6-phosphogluconate dehydrogenase (GND1).	Pentosephosphates	81-98	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1	Saccharomyces cerevisiae S288C	205-209
28352301-6	2017	RESULTS: In this study, we functionally overexpressed four genes involved in the pentose phosphate pathway (PPP): gene YALI0E06479g encoding transketolase (TKL1), gene YALI0F15587g encoding transaldolase (TAL1), gene YALI0E22649g encoding glucose-6-phosphate dehydrogenase (ZWF1), and gene YALI0B15598g encoding 6-phosphogluconate dehydrogenase (GND1).	Pentosephosphates	81-98	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	239-272
28352301-6	2017	RESULTS: In this study, we functionally overexpressed four genes involved in the pentose phosphate pathway (PPP): gene YALI0E06479g encoding transketolase (TKL1), gene YALI0F15587g encoding transaldolase (TAL1), gene YALI0E22649g encoding glucose-6-phosphate dehydrogenase (ZWF1), and gene YALI0B15598g encoding 6-phosphogluconate dehydrogenase (GND1).	Pentosephosphates	81-98	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	274-278
28352301-6	2017	RESULTS: In this study, we functionally overexpressed four genes involved in the pentose phosphate pathway (PPP): gene YALI0E06479g encoding transketolase (TKL1), gene YALI0F15587g encoding transaldolase (TAL1), gene YALI0E22649g encoding glucose-6-phosphate dehydrogenase (ZWF1), and gene YALI0B15598g encoding 6-phosphogluconate dehydrogenase (GND1).	Pentosephosphates	81-98	phosphogluconate dehydrogenase (decarboxylating) GND1	Saccharomyces cerevisiae S288C	346-350
28153010-10	2017	TIGAR promotes the shunting of glycolytic intermediates into the pentose phosphate pathway and thus is of importance for maintaining redox balance.	Pentosephosphates	65-82	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	0-5
28108222-5	2017	In addition, DQ increased glucose 6-phoshate dehydrogenase (G6PDH) activity consistent with glucose diversion towards pentose phosphate pathway.	Pentosephosphates	118-135	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	60-65
28209124-6	2017	RESULTS: Combined metabolomics and transcriptomic analyses revealed that Akt1-induced muscle growth mediated a metabolic shift involving reductions in glycolysis and oxidative phosphorylation, but enhanced pentose phosphate pathway activation and increased branch chain amino acid accumulation.	Pentosephosphates	206-223	thymoma viral proto-oncogene 1	Mus musculus	73-77
28132818-9	2017	SIK3 controls NADP+ reduction by phosphorylating and activating Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway.	Pentosephosphates	138-155	Salt-inducible kinase 3	Drosophila melanogaster	0-4
28132818-9	2017	SIK3 controls NADP+ reduction by phosphorylating and activating Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway.	Pentosephosphates	138-155	Zwischenferment	Drosophila melanogaster	64-97
28132818-9	2017	SIK3 controls NADP+ reduction by phosphorylating and activating Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway.	Pentosephosphates	138-155	Zwischenferment	Drosophila melanogaster	99-103
27464020-6	2017	The main source of NADPH is the pentose phosphate pathway, in which G6PD is the first enzyme.	Pentosephosphates	32-49	glucose-6-phosphate dehydrogenase	Rattus norvegicus	68-72
27702566-5	2017	Microarray and qRT-PCR analysis of human hair follicles after Nrf2 activation using sulforaphane identified the modulation of phase II metabolism, reactive oxygen species clearance, the pentose phosphate pathway, and glutathione homeostasis.	Pentosephosphates	186-203	NFE2 like bZIP transcription factor 2	Homo sapiens	62-66
28122957-2	2017	Phosphoglycerate mutase 1 (PGAM1) is an important glycolytic enzyme that coordinates glycolysis, pentose phosphate pathway, and serine biosynthesis in cancer cells.	Pentosephosphates	97-114	phosphoglycerate mutase 1	Homo sapiens	0-25
28122957-2	2017	Phosphoglycerate mutase 1 (PGAM1) is an important glycolytic enzyme that coordinates glycolysis, pentose phosphate pathway, and serine biosynthesis in cancer cells.	Pentosephosphates	97-114	phosphoglycerate mutase 1	Homo sapiens	27-32
28143530-3	2017	In this study, we investigate the expression of two cancer-related metabolic enzymes, transketolase (TKT) and transketolase-like 1 (TKTL1), involved in the pentose phosphate pathway (PPP), an alternative metabolic pathway for glucose breakdown that could promote cancer by providing the precursors and energy required for rapidly growing cells.	Pentosephosphates	156-173	transketolase	Canis lupus familiaris	86-99
28143530-3	2017	In this study, we investigate the expression of two cancer-related metabolic enzymes, transketolase (TKT) and transketolase-like 1 (TKTL1), involved in the pentose phosphate pathway (PPP), an alternative metabolic pathway for glucose breakdown that could promote cancer by providing the precursors and energy required for rapidly growing cells.	Pentosephosphates	156-173	transketolase	Canis lupus familiaris	101-104
28143530-3	2017	In this study, we investigate the expression of two cancer-related metabolic enzymes, transketolase (TKT) and transketolase-like 1 (TKTL1), involved in the pentose phosphate pathway (PPP), an alternative metabolic pathway for glucose breakdown that could promote cancer by providing the precursors and energy required for rapidly growing cells.	Pentosephosphates	156-173	transketolase like 1	Canis lupus familiaris	110-130
28143530-3	2017	In this study, we investigate the expression of two cancer-related metabolic enzymes, transketolase (TKT) and transketolase-like 1 (TKTL1), involved in the pentose phosphate pathway (PPP), an alternative metabolic pathway for glucose breakdown that could promote cancer by providing the precursors and energy required for rapidly growing cells.	Pentosephosphates	156-173	transketolase like 1	Canis lupus familiaris	132-137
27916418-1	2017	BACKGROUND: Transketolase-like 1 (TKTL1) plays an important role in pentose phosphate pathway (PPP) branch, the main pathway generating nicotinamide adenine dinucleotide phosphate (NADPH) and nucleotides for DNA synthesis.	Pentosephosphates	68-85	transketolase like 1	Homo sapiens	12-32
28036303-2	2017	The inhibition of PKM2 activity is needed for antioxidant response by diverting glucose flux into the pentose phosphate pathway and thus generating sufficient reducing potential.	Pentosephosphates	102-119	pyruvate kinase M1/2	Homo sapiens	18-22
28086956-14	2017	NADPH oxidase-2 and iNOS activities require the oxidation of NADPH, and the pentose phosphate pathway is a main source of NADPH.	Pentosephosphates	76-93	nitric oxide synthase 2, inducible	Mus musculus	20-24
29047080-2	2017	The pentose phosphate pathway is a major source of NADPH redox in the cell.	Pentosephosphates	4-21	2,4-dienoyl-CoA reductase 1	Homo sapiens	51-56
27916418-1	2017	BACKGROUND: Transketolase-like 1 (TKTL1) plays an important role in pentose phosphate pathway (PPP) branch, the main pathway generating nicotinamide adenine dinucleotide phosphate (NADPH) and nucleotides for DNA synthesis.	Pentosephosphates	68-85	transketolase like 1	Homo sapiens	34-39
27755120-1	2017	PURPOSE OF REVIEW: Glucose 6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway.	Pentosephosphates	95-112	glucose-6-phosphate dehydrogenase	Homo sapiens	19-52
27755120-1	2017	PURPOSE OF REVIEW: Glucose 6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway.	Pentosephosphates	95-112	glucose-6-phosphate dehydrogenase	Homo sapiens	54-58
29138681-6	2017	The thioredoxin system is relying on glucose metabolism through the pentose phosphate pathway that provides reducing power in the form of NADPH, the cofactor of thioredoxin reductase (TXNRD).	Pentosephosphates	68-85	thioredoxin	Homo sapiens	4-15
26631910-5	2017	IFNgamma induced mitochondrial co-localization of RIG-I was concomitant with its ability to regulate ROS generation, oxidative phosphorylation (OXPHOS) and key enzymes involved in glycolysis and pentose phosphate pathway.	Pentosephosphates	195-212	interferon gamma	Homo sapiens	0-8
26631910-5	2017	IFNgamma induced mitochondrial co-localization of RIG-I was concomitant with its ability to regulate ROS generation, oxidative phosphorylation (OXPHOS) and key enzymes involved in glycolysis and pentose phosphate pathway.	Pentosephosphates	195-212	DExD/H-box helicase 58	Homo sapiens	50-55
27886975-4	2017	This pathway is comprised of glucose phosphorylation via polyphosphate glucokinase, NADH generation catalyzed by glucose 6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH), electron transfer from NADH to the anode, and glucose 6-phosphate regeneration via the non-oxidative pentose phosphate pathway and gluconeogenesis.	Pentosephosphates	302-319	glucose-6-phosphate dehydrogenase	Homo sapiens	113-146
27886975-4	2017	This pathway is comprised of glucose phosphorylation via polyphosphate glucokinase, NADH generation catalyzed by glucose 6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH), electron transfer from NADH to the anode, and glucose 6-phosphate regeneration via the non-oxidative pentose phosphate pathway and gluconeogenesis.	Pentosephosphates	302-319	glucose-6-phosphate dehydrogenase	Homo sapiens	148-153
29386753-6	2017	Metabolomics studies showed that HIF1alpha overexpression led to increased glycolysis and pentose phosphate pathway intermediates.	Pentosephosphates	90-107	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-42
27914961-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway that ensures sufficient production of coenzyme nicotinamide adenine dinucleotide phosphate (NADPH) by catalyzing the reduction of NADP+ to NADPH.	Pentosephosphates	64-81	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
27914961-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway that ensures sufficient production of coenzyme nicotinamide adenine dinucleotide phosphate (NADPH) by catalyzing the reduction of NADP+ to NADPH.	Pentosephosphates	64-81	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
29138681-6	2017	The thioredoxin system is relying on glucose metabolism through the pentose phosphate pathway that provides reducing power in the form of NADPH, the cofactor of thioredoxin reductase (TXNRD).	Pentosephosphates	68-85	peroxiredoxin 5	Homo sapiens	161-182
29138681-6	2017	The thioredoxin system is relying on glucose metabolism through the pentose phosphate pathway that provides reducing power in the form of NADPH, the cofactor of thioredoxin reductase (TXNRD).	Pentosephosphates	68-85	peroxiredoxin 5	Homo sapiens	184-189
27941691-1	2016	Glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme in the pentose phosphate pathway which produces nicotinamide adenine dinucleotide phosphate (NADPH) to maintain an adequate reducing environment in the cells and is especially important in red blood cells (RBC).	Pentosephosphates	75-92	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
29236388-1	2017	We have studied the effect of hypoxia on the expression level of mRNA of the basic enzymes of pentose-phosphate cycle (G6PD, TKT, TALDO1, PGLS and RPIA) and glucose-6-phosphate isomerase (GPI) in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme 1).	Pentosephosphates	94-111	glucose-6-phosphate dehydrogenase	Homo sapiens	119-123
27941691-1	2016	Glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme in the pentose phosphate pathway which produces nicotinamide adenine dinucleotide phosphate (NADPH) to maintain an adequate reducing environment in the cells and is especially important in red blood cells (RBC).	Pentosephosphates	75-92	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
28090457-2	2016	G6PD plays a key role in the pentose phosphate pathway, which is a major source of nicotinamide adenine dinucleotide phosphate (NADPH).	Pentosephosphates	29-46	glucose-6-phosphate dehydrogenase	Homo sapiens	0-4
27989748-3	2016	This study found that NOX4 directed glucose metabolism not only to the glycolysis but also to pentose phosphate pathway (PPP) pathway for production of NADPH in NSCLC cell lines.	Pentosephosphates	94-111	NADPH oxidase 4	Homo sapiens	22-26
27901115-0	2016	p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway.	Pentosephosphates	104-121	tumor protein p53	Homo sapiens	0-3
28713400-8	2017	Furthermore, transgenic tomato plants overexpressing AdBiL showed higher activities of enzymes such as G6PDH, 6PGDH, NADP-ICDH, and NADP-ME involved in pentose phosphate pathway (PPP).	Pentosephosphates	152-169	E3 ubiquitin ligase AdBiL	Solanum lycopersicum	53-58
28713400-8	2017	Furthermore, transgenic tomato plants overexpressing AdBiL showed higher activities of enzymes such as G6PDH, 6PGDH, NADP-ICDH, and NADP-ME involved in pentose phosphate pathway (PPP).	Pentosephosphates	152-169	NADP-dependent malic enzyme, chloroplastic	Solanum lycopersicum	132-139
27901115-5	2016	PFKFB3 suppression increases the flux of glucose through the pentose phosphate pathway (PPP) to increase nucleotide production, which results in more efficient DNA damage repair and increased cell survival.	Pentosephosphates	61-78	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	0-6
27904781-4	2016	Transketolase (TKT), a thiamine-dependent enzyme that plays a role in the channeling of excess glucose phosphates to glycolysis in the pentose phosphate pathway, was identified as a direct target of miR-497.	Pentosephosphates	135-152	transketolase	Homo sapiens	0-13
27904781-4	2016	Transketolase (TKT), a thiamine-dependent enzyme that plays a role in the channeling of excess glucose phosphates to glycolysis in the pentose phosphate pathway, was identified as a direct target of miR-497.	Pentosephosphates	135-152	transketolase	Homo sapiens	15-18
27904781-4	2016	Transketolase (TKT), a thiamine-dependent enzyme that plays a role in the channeling of excess glucose phosphates to glycolysis in the pentose phosphate pathway, was identified as a direct target of miR-497.	Pentosephosphates	135-152	microRNA 497	Homo sapiens	199-206
27636396-6	2016	The latter effect was via glucose 6-phosphate dehydrogenase activation, as confirmed by increased enzyme activity and enhancement of the pentose phosphate pathway rate.	Pentosephosphates	137-154	glucose-6-phosphate dehydrogenase	Homo sapiens	26-59
27284106-1	2016	Glucose-6-phosphate dehydrogenase (G6PD), a rate-limiting enzyme of the pentose phosphate pathway, plays important roles in redox regulation and de novo lipogenesis.	Pentosephosphates	72-89	glucose-6-phosphate dehydrogenase 2	Mus musculus	0-33
27895744-7	2016	Genes of the pentose phosphate pathway (PPP) were significantly enriched in the antisense miRNA-221-transfected MCF7-FR cells.	Pentosephosphates	13-30	microRNA 221	Homo sapiens	90-99
27703206-1	2016	Transaldolase 1 (TALDO1) is a rate-limiting enzyme involved in the pentose phosphate pathway, which is traditionally thought to occur in the cytoplasm.	Pentosephosphates	67-84	transaldolase 1	Homo sapiens	0-15
27703206-1	2016	Transaldolase 1 (TALDO1) is a rate-limiting enzyme involved in the pentose phosphate pathway, which is traditionally thought to occur in the cytoplasm.	Pentosephosphates	67-84	transaldolase 1	Homo sapiens	17-23
27748844-7	2016	We found that glycolysis and activities of pentose phosphate pathway (PPP) regulatory enzymes were significantly different among the carcinoma cell lines, particularly in the mitochondrial hexokinase (HK) activity which was higher in the BCPAP cells than that in the TPC1 cell line which showed a balanced distribution of HK activity between cytoplasmic and mitochondrial subcellular localizations.	Pentosephosphates	43-60	hexokinase 1	Homo sapiens	189-199
27748844-7	2016	We found that glycolysis and activities of pentose phosphate pathway (PPP) regulatory enzymes were significantly different among the carcinoma cell lines, particularly in the mitochondrial hexokinase (HK) activity which was higher in the BCPAP cells than that in the TPC1 cell line which showed a balanced distribution of HK activity between cytoplasmic and mitochondrial subcellular localizations.	Pentosephosphates	43-60	hexokinase 1	Homo sapiens	201-203
27748844-7	2016	We found that glycolysis and activities of pentose phosphate pathway (PPP) regulatory enzymes were significantly different among the carcinoma cell lines, particularly in the mitochondrial hexokinase (HK) activity which was higher in the BCPAP cells than that in the TPC1 cell line which showed a balanced distribution of HK activity between cytoplasmic and mitochondrial subcellular localizations.	Pentosephosphates	43-60	two pore segment channel 1	Homo sapiens	267-271
27748844-7	2016	We found that glycolysis and activities of pentose phosphate pathway (PPP) regulatory enzymes were significantly different among the carcinoma cell lines, particularly in the mitochondrial hexokinase (HK) activity which was higher in the BCPAP cells than that in the TPC1 cell line which showed a balanced distribution of HK activity between cytoplasmic and mitochondrial subcellular localizations.	Pentosephosphates	43-60	hexokinase 1	Homo sapiens	322-324
27405778-1	2016	Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) plays a key regulatory function in glucose oxidation by mediating fluxes through glycolysis or the pentose phosphate pathway (PPP) in an oxidative stress-dependent fashion.	Pentosephosphates	148-165	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-40
27405778-1	2016	Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) plays a key regulatory function in glucose oxidation by mediating fluxes through glycolysis or the pentose phosphate pathway (PPP) in an oxidative stress-dependent fashion.	Pentosephosphates	148-165	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	42-47
27284106-1	2016	Glucose-6-phosphate dehydrogenase (G6PD), a rate-limiting enzyme of the pentose phosphate pathway, plays important roles in redox regulation and de novo lipogenesis.	Pentosephosphates	72-89	glucose-6-phosphate dehydrogenase 2	Mus musculus	35-39
27063053-2	2016	In this study, we have reported for the first time the presence of the two key enzymes of the pentose phosphate pathway (PPP), glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in ovine spermatozoa by indirect immunofluorescence, Western blotting, in-gel activity, and reverse transcription polymerase chain reaction analysis.	Pentosephosphates	94-111	glucose-6-phosphate dehydrogenase	Homo sapiens	127-160
27164560-0	2016	Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes.	Pentosephosphates	117-134	nuclear receptor binding SET domain protein 2	Homo sapiens	54-58
27164560-7	2016	Its overexpression coordinately up-regulated hexokinase 2 (HK2) and glucose-6-phosphate dehydrogenase (G6PD), two key enzymes of glycolysis and the pentose phosphate pathway (PPP), as well as TP53-induced glycolysis regulatory phosphatase TIGAR.	Pentosephosphates	148-165	hexokinase 2	Homo sapiens	59-62
27164560-7	2016	Its overexpression coordinately up-regulated hexokinase 2 (HK2) and glucose-6-phosphate dehydrogenase (G6PD), two key enzymes of glycolysis and the pentose phosphate pathway (PPP), as well as TP53-induced glycolysis regulatory phosphatase TIGAR.	Pentosephosphates	148-165	glucose-6-phosphate dehydrogenase	Homo sapiens	103-107
27328773-2	2016	This study implicates ribose-5-phosphate isomerase (RPIA), a key regulator of the pentose phosphate pathway, in the control of autophagy.	Pentosephosphates	82-99	ribose 5-phosphate isomerase A	Homo sapiens	22-50
27328773-2	2016	This study implicates ribose-5-phosphate isomerase (RPIA), a key regulator of the pentose phosphate pathway, in the control of autophagy.	Pentosephosphates	82-99	ribose 5-phosphate isomerase A	Homo sapiens	52-56
27585591-5	2016	Thus, due to lack of inhibition of PFKFB3, IKKbeta-deficient cells exhibit elevated aerobic glycolysis and lactate production, leading to less glucose carbons contributing to tricarboxylic acid (TCA) cycle intermediates and the pentose phosphate pathway, which results in increased glutamine dependence for both TCA cycle intermediates and reactive oxygen species suppression.	Pentosephosphates	228-245	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	43-50
27246794-2	2016	Activation of various enzymes, including ones involved in the pentose phosphate pathway, by NF-E2-related factor 2 (NRF2), controls redox homeostasis in HCC.	Pentosephosphates	62-79	NFE2 like bZIP transcription factor 2	Homo sapiens	92-114
27246794-2	2016	Activation of various enzymes, including ones involved in the pentose phosphate pathway, by NF-E2-related factor 2 (NRF2), controls redox homeostasis in HCC.	Pentosephosphates	62-79	NFE2 like bZIP transcription factor 2	Homo sapiens	116-120
27381654-4	2016	RESULTS: Stringent relative quantification of the patient"s protein levels revealed reduced levels of P5N, and unexpectedly, also decreased levels of transketolase, an enzyme involved in the nonoxidative phase of the pentose phosphate pathway, one of the few key pathways active in RBCs.	Pentosephosphates	217-234	transketolase	Homo sapiens	150-163
27045080-5	2016	Replacement of wild type PKM2 with a mutant (T454A) enhances mitochondrial respiration, decreases pentose phosphate pathway, and enhances chemosensitivity in A549 cells.	Pentosephosphates	98-115	pyruvate kinase M1/2	Homo sapiens	25-29
27174163-3	2016	The pentose phosphate pathway is a key route of glucose metabolism in most organisms, providing NADPH for use as a cellular reductant and various carbohydrate intermediates used in cellular metabolism.	Pentosephosphates	4-21	2,4-dienoyl-CoA reductase 1	Homo sapiens	96-101
26710800-6	2016	In addition, pharmacologic inhibition of the pentose phosphate pathway decreased rates of disulfide reduction and proteolysis in the phagosome, implicating NADPH as a source of phagosomal reductive energy.	Pentosephosphates	45-62	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	156-161
27256465-1	2016	Previous study showed that TIGAR (TP53-induced glycolysis and apoptosis regulator) protected ischemic brain injury via enhancing pentose phosphate pathway (PPP) flux and preserving mitochondria function.	Pentosephosphates	129-146	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	27-32
27256465-1	2016	Previous study showed that TIGAR (TP53-induced glycolysis and apoptosis regulator) protected ischemic brain injury via enhancing pentose phosphate pathway (PPP) flux and preserving mitochondria function.	Pentosephosphates	129-146	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	34-81
27208232-5	2016	Loss of ASKalpha attenuated, whereas its overexpression enhanced, diverse PTI responses, ultimately affecting susceptibility to the bacterial pathogen Pseudomonas syringae Glucose-6-phosphate dehydrogenase (G6PD), the key enzyme of the oxidative pentose phosphate pathway, provides reducing equivalents important for defense responses and is a direct target of ASKalpha.	Pentosephosphates	246-263	shaggy-related kinase 11	Arabidopsis thaliana	8-16
27230471-1	2016	Ribose-5-phosphate isomerase (RPI) belongs to the non-oxidative branch of the pentose phosphate pathway, catalysing the inter-conversion of D-ribose-5-phosphate and D-ribulose-5-phosphate.	Pentosephosphates	78-95	ribose 5-phosphate isomerase A	Mus musculus	0-28
27230471-1	2016	Ribose-5-phosphate isomerase (RPI) belongs to the non-oxidative branch of the pentose phosphate pathway, catalysing the inter-conversion of D-ribose-5-phosphate and D-ribulose-5-phosphate.	Pentosephosphates	78-95	ribose 5-phosphate isomerase A	Mus musculus	30-33
27049827-6	2016	Suppression of PFKP not only impaired cell proliferation by inducing cell cycle arrest and apoptosis, but also led to decreased glycolysis, pentose phosphate pathway and nucleotide biosynthesis, accompanied by activated tricarboxylic acid cycle in ccRCC cells.	Pentosephosphates	140-157	phosphofructokinase, platelet	Homo sapiens	15-19
27078845-0	2016	Histone deacetylase inhibitor-induced cancer stem cells exhibit high pentose phosphate pathway metabolism.	Pentosephosphates	69-86	histone deacetylase 9	Homo sapiens	0-19
27078845-10	2016	HDAC inhibitor-induced dedifferentiation promoted metabolic reprogramming into the pentose phosphate pathway, which is targeted effectively by G6PD inhibition.	Pentosephosphates	83-100	histone deacetylase 9	Homo sapiens	0-4
27078845-10	2016	HDAC inhibitor-induced dedifferentiation promoted metabolic reprogramming into the pentose phosphate pathway, which is targeted effectively by G6PD inhibition.	Pentosephosphates	83-100	glucose-6-phosphate dehydrogenase	Homo sapiens	143-147
26568303-7	2016	Finally, we showed that NAMPT increased the pool of NAD+ that could be converted to NADPH through the pentose phosphate pathway and inhibited the depletion of reduced glutathione under glucose deprivation.	Pentosephosphates	102-119	nicotinamide phosphoribosyltransferase	Homo sapiens	24-29
26568303-7	2016	Finally, we showed that NAMPT increased the pool of NAD+ that could be converted to NADPH through the pentose phosphate pathway and inhibited the depletion of reduced glutathione under glucose deprivation.	Pentosephosphates	102-119	2,4-dienoyl-CoA reductase 1	Homo sapiens	84-89
27020289-6	2016	In a previous study, we have demonstrated that overexpression of single genes of the oxidative pentose phosphate pathway (PPP) had a positive influence on recombinant production of cytosolic human superoxide dismutase (hSOD).	Pentosephosphates	95-112	superoxide dismutase 1	Homo sapiens	219-223
26827633-1	2016	OBJECTIVE: The enzyme glucose-6-phosphate dehydrogenase (G6PD) catalyses the first step in the pentose phosphate pathway, producing nicotinamide adenine dinucleotide phosphate (NADPH).	Pentosephosphates	95-112	glucose-6-phosphate dehydrogenase	Homo sapiens	22-55
26827633-1	2016	OBJECTIVE: The enzyme glucose-6-phosphate dehydrogenase (G6PD) catalyses the first step in the pentose phosphate pathway, producing nicotinamide adenine dinucleotide phosphate (NADPH).	Pentosephosphates	95-112	glucose-6-phosphate dehydrogenase	Homo sapiens	57-61
27167341-7	2016	Activation of Nrf2 pathway resulted in upregulation of metabolic genes involved in pentose phosphate pathway, glutaminolysis and glutathione biosynthesis.	Pentosephosphates	83-100	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
26434592-2	2016	By comparing the treatment effects of the antimalarials chloroquine (CQ) and quinacrine (Q) on KRAS mutant lung cancer cells, we demonstrate that inhibition of the oxidative arm of the pentose phosphate pathway (oxPPP) is required for antimalarial induced apoptosis.	Pentosephosphates	185-202	KRAS proto-oncogene, GTPase	Homo sapiens	95-99
27148686-0	2016	Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma.	Pentosephosphates	27-44	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
27148686-0	2016	Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma.	Pentosephosphates	27-44	telomerase reverse transcriptase	Homo sapiens	12-16
27148686-6	2016	Inhibition of hTERT either by Costunolide, or by siRNA or dominant-negative hTERT (DN-hTERT) abrogated (i) expression of Glucose-6-phosphate dehydrogenase (G6PD) and Transketolase (TKT) - two major nodes in the pentose phosphate (PPP) pathway; and (ii) phosphorylation of glycogen synthase (GS).	Pentosephosphates	211-228	telomerase reverse transcriptase	Homo sapiens	14-19
27153534-4	2016	Phosphorylation of these enzymes leads to enhanced HK activity to sustain glucose uptake but reduced activity of FBP1 to block the gluconeogenic route and reduced activity of PFK1 and ENO1 to moderate drop of glucose-6-phosphate and to repartition more carbon flux to pentose phosphate pathway (PPP), maintaining cellular energy and redox homeostasis at cellular and organismal levels.	Pentosephosphates	268-285	hexokinase 1	Homo sapiens	51-53
27153534-4	2016	Phosphorylation of these enzymes leads to enhanced HK activity to sustain glucose uptake but reduced activity of FBP1 to block the gluconeogenic route and reduced activity of PFK1 and ENO1 to moderate drop of glucose-6-phosphate and to repartition more carbon flux to pentose phosphate pathway (PPP), maintaining cellular energy and redox homeostasis at cellular and organismal levels.	Pentosephosphates	268-285	fructose-bisphosphatase 1	Homo sapiens	113-117
27088854-3	2016	Importantly, KHK-A acts as a protein kinase, phosphorylating and activating phosphoribosyl pyrophosphate synthetase 1 (PRPS1) to promote pentose phosphate pathway-dependent de novo nucleic acid synthesis and HCC formation.	Pentosephosphates	137-154	ketohexokinase	Homo sapiens	13-16
27153534-4	2016	Phosphorylation of these enzymes leads to enhanced HK activity to sustain glucose uptake but reduced activity of FBP1 to block the gluconeogenic route and reduced activity of PFK1 and ENO1 to moderate drop of glucose-6-phosphate and to repartition more carbon flux to pentose phosphate pathway (PPP), maintaining cellular energy and redox homeostasis at cellular and organismal levels.	Pentosephosphates	268-285	phosphofructokinase, muscle	Homo sapiens	175-179
27153534-4	2016	Phosphorylation of these enzymes leads to enhanced HK activity to sustain glucose uptake but reduced activity of FBP1 to block the gluconeogenic route and reduced activity of PFK1 and ENO1 to moderate drop of glucose-6-phosphate and to repartition more carbon flux to pentose phosphate pathway (PPP), maintaining cellular energy and redox homeostasis at cellular and organismal levels.	Pentosephosphates	268-285	enolase 1	Homo sapiens	184-188
27143001-0	2016	A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system.	Pentosephosphates	100-117	Kelch-like ECH-associated protein 1	Rattus norvegicus	134-139
27143001-0	2016	A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system.	Pentosephosphates	100-117	NFE2 like bZIP transcription factor 2	Rattus norvegicus	140-144
27088854-3	2016	Importantly, KHK-A acts as a protein kinase, phosphorylating and activating phosphoribosyl pyrophosphate synthetase 1 (PRPS1) to promote pentose phosphate pathway-dependent de novo nucleic acid synthesis and HCC formation.	Pentosephosphates	137-154	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	76-117
27088854-3	2016	Importantly, KHK-A acts as a protein kinase, phosphorylating and activating phosphoribosyl pyrophosphate synthetase 1 (PRPS1) to promote pentose phosphate pathway-dependent de novo nucleic acid synthesis and HCC formation.	Pentosephosphates	137-154	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	119-124
27070696-2	2016	(2016) reveal that mTORC1 orchestrates the metabolic reprogramming of cancer cells in response to glycolytic inhibitors, bypassing glycolysis by increasing glutamine uptake and pentose phosphate flux to generate energy and biomass.	Pentosephosphates	177-194	CREB regulated transcription coactivator 1	Mus musculus	19-25
27052953-3	2016	Active mTORC1 directs increased glucose flux via the pentose phosphate pathway back into glycolysis, thereby circumventing a glycolysis block and ensuring adequate ATP and biomass production.	Pentosephosphates	53-70	CREB regulated transcription coactivator 1	Mus musculus	7-13
27232511-3	2016	The results in this study confirm and extend previous observations that RRx-001 exerts its anti-proliferative effect, at least partially, through interference with glucose 6 phosphate dehydrogenase (G6PD), a key enzyme in the pentose phosphate pathway, responsible for maintaining adequate levels of the major cellular reductant, NADPH.	Pentosephosphates	226-243	glucose-6-phosphate dehydrogenase	Homo sapiens	164-197
27040960-2	2016	Glucose-6-phosphate dehydrogenase (G6PD) is part of the pentose phosphate pathway, and its main physiologic role is to provide NADPH.	Pentosephosphates	56-73	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
27040960-2	2016	Glucose-6-phosphate dehydrogenase (G6PD) is part of the pentose phosphate pathway, and its main physiologic role is to provide NADPH.	Pentosephosphates	56-73	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
27040960-2	2016	Glucose-6-phosphate dehydrogenase (G6PD) is part of the pentose phosphate pathway, and its main physiologic role is to provide NADPH.	Pentosephosphates	56-73	2,4-dienoyl-CoA reductase 1	Homo sapiens	127-132
27232511-3	2016	The results in this study confirm and extend previous observations that RRx-001 exerts its anti-proliferative effect, at least partially, through interference with glucose 6 phosphate dehydrogenase (G6PD), a key enzyme in the pentose phosphate pathway, responsible for maintaining adequate levels of the major cellular reductant, NADPH.	Pentosephosphates	226-243	glucose-6-phosphate dehydrogenase	Homo sapiens	199-203
26537442-6	2016	We have recently uncovered that stress-inducible CO in and around cancer cells suppresses CBS to result in decreased methylation of PFKFB3, the enzyme regulating PFK-1, leading to a shift of glucose biotransformation from glycolysis toward pentose phosphate pathway; such a metabolic remodeling causes chemoresistance through increasing NADPH and reduced glutathione under stress conditions for cancer cells.	Pentosephosphates	240-257	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	132-138
26537442-6	2016	We have recently uncovered that stress-inducible CO in and around cancer cells suppresses CBS to result in decreased methylation of PFKFB3, the enzyme regulating PFK-1, leading to a shift of glucose biotransformation from glycolysis toward pentose phosphate pathway; such a metabolic remodeling causes chemoresistance through increasing NADPH and reduced glutathione under stress conditions for cancer cells.	Pentosephosphates	240-257	phosphofructokinase, muscle	Homo sapiens	162-167
27009267-4	2016	Excess G6PD shunted glucose into the pentose phosphate pathway, resulting in NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) accumulation and reactive oxygen species (ROS) consumption.	Pentosephosphates	37-54	glucose-6-phosphate dehydrogenase	Homo sapiens	7-11
26975021-5	2016	Concurrently, bladder cancer metabolism displays an increased expression of genes favoring the pentose phosphate pathway (glucose-6-phosphate dehydrogenase [G6PD]) and the fatty-acid synthesis (fatty acid synthase [FASN]), along with a decrease of AMP-activated protein kinase (AMPK) and Krebs cycle activities.	Pentosephosphates	95-112	glucose-6-phosphate dehydrogenase	Homo sapiens	122-155
26975021-5	2016	Concurrently, bladder cancer metabolism displays an increased expression of genes favoring the pentose phosphate pathway (glucose-6-phosphate dehydrogenase [G6PD]) and the fatty-acid synthesis (fatty acid synthase [FASN]), along with a decrease of AMP-activated protein kinase (AMPK) and Krebs cycle activities.	Pentosephosphates	95-112	glucose-6-phosphate dehydrogenase	Homo sapiens	157-161
26769491-5	2016	Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YDeltaGP/XK/XI strain.	Pentosephosphates	74-91	phosphogluconate dehydrogenase (decarboxylating) GND1	Saccharomyces cerevisiae S288C	101-105
26769491-5	2016	Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YDeltaGP/XK/XI strain.	Pentosephosphates	74-91	6-phosphogluconolactonase SOL3	Saccharomyces cerevisiae S288C	107-111
26769491-5	2016	Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YDeltaGP/XK/XI strain.	Pentosephosphates	74-91	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1	Saccharomyces cerevisiae S288C	113-117
26769491-5	2016	Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YDeltaGP/XK/XI strain.	Pentosephosphates	74-91	ribose-5-phosphate isomerase RKI1	Saccharomyces cerevisiae S288C	119-123
26769491-5	2016	Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YDeltaGP/XK/XI strain.	Pentosephosphates	74-91	transketolase TKL1	Saccharomyces cerevisiae S288C	129-133
26769491-5	2016	Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YDeltaGP/XK/XI strain.	Pentosephosphates	74-91	aconitate hydratase ACO1	Saccharomyces cerevisiae S288C	178-182
26769491-5	2016	Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YDeltaGP/XK/XI strain.	Pentosephosphates	74-91	aconitate hydratase ACO2	Saccharomyces cerevisiae S288C	184-188
26769491-5	2016	Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YDeltaGP/XK/XI strain.	Pentosephosphates	74-91	succinate dehydrogenase iron-sulfur protein subunit SDH2	Saccharomyces cerevisiae S288C	190-194
26769491-5	2016	Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YDeltaGP/XK/XI strain.	Pentosephosphates	74-91	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	196-200
26769491-5	2016	Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YDeltaGP/XK/XI strain.	Pentosephosphates	74-91	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	202-206
26769491-5	2016	Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YDeltaGP/XK/XI strain.	Pentosephosphates	74-91	F1F0 ATP synthase subunit d	Saccharomyces cerevisiae S288C	208-212
26769491-5	2016	Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YDeltaGP/XK/XI strain.	Pentosephosphates	74-91	F1F0 ATP synthase subunit k	Saccharomyces cerevisiae S288C	214-219
26769491-5	2016	Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YDeltaGP/XK/XI strain.	Pentosephosphates	74-91	succinate dehydrogenase membrane anchor subunit SDH4	Saccharomyces cerevisiae S288C	221-225
26769491-5	2016	Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YDeltaGP/XK/XI strain.	Pentosephosphates	74-91	succinate dehydrogenase cytochrome b subunit SDH3	Saccharomyces cerevisiae S288C	227-231
26769491-5	2016	Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YDeltaGP/XK/XI strain.	Pentosephosphates	74-91	Cmc2p	Saccharomyces cerevisiae S288C	233-237
26769491-5	2016	Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YDeltaGP/XK/XI strain.	Pentosephosphates	74-91	F1F0 ATP synthase subunit epsilon	Saccharomyces cerevisiae S288C	243-248
25417049-6	2016	Pharmacological inhibition of G6PD-activity enhanced the toxicity of 4-ClBQ, suggesting that the protective function of the pentose phosphate pathway is functional in 4-ClBQ-treated cells.	Pentosephosphates	124-141	glucose-6-phosphate dehydrogenase	Homo sapiens	30-34
26708478-5	2016	This could indicate its possible regulatory role not only towards transketolase, but also towards the pentose phosphate pathway of carbohydrate metabolism overall, taking into account the fact that it inhibits not only transketolase but also another enzyme of the pentose phosphate pathway--glucose 6-phosphate dehydrogenase [Eggleston L.V., Krebs H.A.	Pentosephosphates	102-119	transketolase	Homo sapiens	66-79
26708478-5	2016	This could indicate its possible regulatory role not only towards transketolase, but also towards the pentose phosphate pathway of carbohydrate metabolism overall, taking into account the fact that it inhibits not only transketolase but also another enzyme of the pentose phosphate pathway--glucose 6-phosphate dehydrogenase [Eggleston L.V., Krebs H.A.	Pentosephosphates	102-119	transketolase	Homo sapiens	219-232
26708478-5	2016	This could indicate its possible regulatory role not only towards transketolase, but also towards the pentose phosphate pathway of carbohydrate metabolism overall, taking into account the fact that it inhibits not only transketolase but also another enzyme of the pentose phosphate pathway--glucose 6-phosphate dehydrogenase [Eggleston L.V., Krebs H.A.	Pentosephosphates	264-281	transketolase	Homo sapiens	66-79
26708478-5	2016	This could indicate its possible regulatory role not only towards transketolase, but also towards the pentose phosphate pathway of carbohydrate metabolism overall, taking into account the fact that it inhibits not only transketolase but also another enzyme of the pentose phosphate pathway--glucose 6-phosphate dehydrogenase [Eggleston L.V., Krebs H.A.	Pentosephosphates	264-281	transketolase	Homo sapiens	219-232
26724864-1	2016	The deletion of PHO13 (pho13Delta) in Saccharomyces cerevisiae, encoding a phosphatase enzyme of unknown specificity, results in the transcriptional activation of genes related to the pentose phosphate pathway (PPP) such as TAL1 encoding transaldolase.	Pentosephosphates	184-201	4-nitrophenylphosphatase	Saccharomyces cerevisiae S288C	16-21
26724864-1	2016	The deletion of PHO13 (pho13Delta) in Saccharomyces cerevisiae, encoding a phosphatase enzyme of unknown specificity, results in the transcriptional activation of genes related to the pentose phosphate pathway (PPP) such as TAL1 encoding transaldolase.	Pentosephosphates	184-201	4-nitrophenylphosphatase	Saccharomyces cerevisiae S288C	23-33
26774962-5	2016	Indeed, PHD1(-/-) neurons enhanced glucose flux through the oxidative pentose phosphate pathway by diverting glucose away from glycolysis.	Pentosephosphates	70-87	egl-9 family hypoxia-inducible factor 2	Mus musculus	8-12
26450510-4	2016	Proteins involved in glycolysis, acetate metabolism, fatty acid synthesis, TCA cycle, glyoxylate cycle, the pentose phosphate pathway, respiration, transportation, and stress response were found to be upregulated in  faa1 faa4 [Acot5s] as compared to the wild type.	Pentosephosphates	108-125	long-chain fatty acid-CoA ligase FAA1	Saccharomyces cerevisiae S288C	217-226
26904936-5	2016	Mechanistically, we show that an early burst in oxidative phosphorylation and elevated reactive oxygen species generation mediates increased NRF2 activity, which in turn initiates the HIFalpha-mediated glycolytic shift and may modulate glucose redistribution to the pentose phosphate pathway.	Pentosephosphates	266-283	NFE2 like bZIP transcription factor 2	Homo sapiens	141-145
29910900-1	2016	DERA, 2-deoxyribose-5-phosphate aldolase, catalyzes the retro-aldol cleavage of 2-deoxy-ribose-5-phosphate (dR5P) into glyceraldehyde-3-phosphate (G3P) and acetaldehyde in a branch of the pentose phosphate pathway.	Pentosephosphates	188-205	deoxyribose-phosphate aldolase	Homo sapiens	0-4
29910900-1	2016	DERA, 2-deoxyribose-5-phosphate aldolase, catalyzes the retro-aldol cleavage of 2-deoxy-ribose-5-phosphate (dR5P) into glyceraldehyde-3-phosphate (G3P) and acetaldehyde in a branch of the pentose phosphate pathway.	Pentosephosphates	188-205	deoxyribose-phosphate aldolase	Homo sapiens	6-40
26650256-1	2016	BACKGROUND: Transketolase-like protein 1 (TKTL1) is an isoform of tranketolase, a key protein in a cancer cell"s glucose metabolism that causes rapid cell growth and controls the non-oxidative part of the pentose phosphate pathway (PPP).	Pentosephosphates	205-222	transketolase like 1	Homo sapiens	12-40
26774701-8	2016	In vitro assays confirmed that inhibition of PKM2 activity could modulate the flux of glycolytic intermediates in support of cell proliferation through the increased pentose phosphate pathway (PPP).	Pentosephosphates	166-183	pyruvate kinase M1/2	Rattus norvegicus	45-49
26582802-5	2016	PKM2 has lower catalytic activity resulting in decreased glycolytic flux and the accumulation of upstream intermediates that were redirected to the pentose phosphate pathway and serine/folate biosynthesis, 2 important NADPH producing pathways stemming from glycolysis.	Pentosephosphates	148-165	pyruvate kinase, muscle	Mus musculus	0-4
26655504-10	2016	Moreover, we found, upon attenuation of PGAM1, its substrate 3-PG (3-phosphoglycerate) was up-regulated and product 2-PG (2-phosphoglycerate) was down-regulated, which consequently inhibited aerobic glycolysis and oxidative pentose phosphate pathway (PPP) that are essential to cancer cell proliferation.	Pentosephosphates	224-241	phosphoglycerate mutase 1	Homo sapiens	40-45
26621836-2	2016	The current study demonstrated that BAG3 directly interacted with glucose 6 phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway (PPP).	Pentosephosphates	140-157	BAG cochaperone 3	Homo sapiens	36-40
26621836-2	2016	The current study demonstrated that BAG3 directly interacted with glucose 6 phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway (PPP).	Pentosephosphates	140-157	glucose-6-phosphate dehydrogenase	Homo sapiens	66-99
26621836-2	2016	The current study demonstrated that BAG3 directly interacted with glucose 6 phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway (PPP).	Pentosephosphates	140-157	glucose-6-phosphate dehydrogenase	Homo sapiens	101-105
26650256-1	2016	BACKGROUND: Transketolase-like protein 1 (TKTL1) is an isoform of tranketolase, a key protein in a cancer cell"s glucose metabolism that causes rapid cell growth and controls the non-oxidative part of the pentose phosphate pathway (PPP).	Pentosephosphates	205-222	transketolase like 1	Homo sapiens	42-47
27974910-3	2016	Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme in the pentose phosphate pathway, which leads to the production of NADPH.	Pentosephosphates	61-78	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
26573871-4	2016	The underlying mechanisms were defined that the anticancer effects of apigenin were reversed by ectopic GLUT1 overexpression and galactose supplementation, through activation of pentose phosphate pathway-mediated NADPH generation.	Pentosephosphates	178-195	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	104-109
26481897-1	2016	Transketolase is a connecting link between glycolytic and pentose phosphate pathway, which is considered as the rate-limiting step due to synthesis of large number of ATP molecule and it can be proposed as a plausible target facilitating the growth of cancerous cells suggesting its potential role in cancer.	Pentosephosphates	58-75	transketolase	Homo sapiens	0-13
26465354-1	2016	The preimplantation bovine embryo displays sexual dimorphism in glucose sensitivity and interferon-tau (IFNT) secretion that are negated by inhibition of the pentose phosphate pathway, suggesting that the association between glucose metabolism and IFNT likely underpins the selective loss of female embryos.	Pentosephosphates	158-175	interferon tau-2	Bos taurus	88-102
26465354-1	2016	The preimplantation bovine embryo displays sexual dimorphism in glucose sensitivity and interferon-tau (IFNT) secretion that are negated by inhibition of the pentose phosphate pathway, suggesting that the association between glucose metabolism and IFNT likely underpins the selective loss of female embryos.	Pentosephosphates	158-175	interferon tau-2	Bos taurus	104-108
26465354-1	2016	The preimplantation bovine embryo displays sexual dimorphism in glucose sensitivity and interferon-tau (IFNT) secretion that are negated by inhibition of the pentose phosphate pathway, suggesting that the association between glucose metabolism and IFNT likely underpins the selective loss of female embryos.	Pentosephosphates	158-175	interferon tau-2	Bos taurus	248-252
27688915-0	2016	Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons.	Pentosephosphates	60-77	Wnt family member 5A	Homo sapiens	0-5
27688915-7	2016	We report here that Wnt5a induces an increase in glucose uptake and glycolytic rate and an increase in the activity of the pentose phosphate pathway; the effects of Wnt5a require the intracellular generation of nitric oxide.	Pentosephosphates	123-140	Wnt family member 5A	Homo sapiens	20-25
27688915-7	2016	We report here that Wnt5a induces an increase in glucose uptake and glycolytic rate and an increase in the activity of the pentose phosphate pathway; the effects of Wnt5a require the intracellular generation of nitric oxide.	Pentosephosphates	123-140	Wnt family member 5A	Homo sapiens	165-170
26564104-1	2016	BACKGROUND AND PURPOSE: Our previous study has defined a role of TP53-induced glycolysis and apoptosis regulator in neuroprotection against ischemic injury through increasing the flow of pentose phosphate pathway.	Pentosephosphates	187-204	tumor protein p53	Rattus norvegicus	65-69
26687144-5	2015	Functional studies demonstrated cytosolic localization of hISPD, and cytidyltransferase activity toward pentose phosphates, including ribulose 5-phosphate, ribose 5-phosphate, and ribitol 5-phosphate.	Pentosephosphates	104-122	CDP-L-ribitol pyrophosphorylase A	Homo sapiens	58-63
26527315-4	2015	5-FU treatment-resistant cells show a de novo expression of pyruvate kinase M1 (PKM1) and repression of PKM2, correlating with repression of the pentose phosphate pathway, decrease in NADPH level and in antioxidant defenses, promoting PKM2 oxidation and acquisition of stem-like phenotype.	Pentosephosphates	145-162	pyruvate kinase M1/2	Homo sapiens	104-108
25808097-0	2015	Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate Pathway.	Pentosephosphates	104-121	pyruvate kinase M1/2	Homo sapiens	0-18
26884841-7	2015	Glucose-6-phosphate dehydrogenase, transketolase and transaldolase 1, three key enzymes regulated pentose phosphate pathway, were all marked in the same exosomal parts of proteins between two ovarian cell lines.	Pentosephosphates	98-115	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
26884841-7	2015	Glucose-6-phosphate dehydrogenase, transketolase and transaldolase 1, three key enzymes regulated pentose phosphate pathway, were all marked in the same exosomal parts of proteins between two ovarian cell lines.	Pentosephosphates	98-115	transketolase	Homo sapiens	35-48
26884841-7	2015	Glucose-6-phosphate dehydrogenase, transketolase and transaldolase 1, three key enzymes regulated pentose phosphate pathway, were all marked in the same exosomal parts of proteins between two ovarian cell lines.	Pentosephosphates	98-115	transaldolase 1	Homo sapiens	53-68
27974910-3	2016	Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme in the pentose phosphate pathway, which leads to the production of NADPH.	Pentosephosphates	61-78	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
26248089-0	2015	MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells.	Pentosephosphates	25-42	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	82-87
26572986-3	2015	Our previous study identified the enzyme GLUCOSE-6-PHOSPHATE DEHYDROGENASE 1 (G6PD1) as a key regulator contributing to the phenomenon of overcompensation via its role in the oxidative pentose phosphate pathway (OPPP).	Pentosephosphates	185-202	glucose-6-phosphate dehydrogenase 1	Arabidopsis thaliana	41-76
26572986-3	2015	Our previous study identified the enzyme GLUCOSE-6-PHOSPHATE DEHYDROGENASE 1 (G6PD1) as a key regulator contributing to the phenomenon of overcompensation via its role in the oxidative pentose phosphate pathway (OPPP).	Pentosephosphates	185-202	glucose-6-phosphate dehydrogenase 1	Arabidopsis thaliana	78-83
26530903-3	2015	In this setting, Nrf2 expression conferred metabolic alterations in keratinocytes that were protumorigenic in nature, affecting enzymes involved in glutathione biosynthesis or in the oxidative pentose phosphate pathway and other NADPH-producing enzymes.	Pentosephosphates	193-210	nuclear factor, erythroid derived 2, like 2	Mus musculus	17-21
25772235-4	2015	One putative autophagy stimulator, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), drives flux through pentose phosphate pathway.	Pentosephosphates	119-136	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Homo sapiens	35-88
25772235-4	2015	One putative autophagy stimulator, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), drives flux through pentose phosphate pathway.	Pentosephosphates	119-136	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Homo sapiens	90-96
26434776-3	2015	Metabolomics analyses reveal that BCR-ABL-ERK signaling in H929 cells drives the pentose phosphate pathway (PPP) and RNA biosynthesis, where pathway inhibition via imatinib results in marked PPP impairment and an accumulation of RNA nucleotides and negative regulation of mRNA.	Pentosephosphates	81-98	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	34-41
26434776-3	2015	Metabolomics analyses reveal that BCR-ABL-ERK signaling in H929 cells drives the pentose phosphate pathway (PPP) and RNA biosynthesis, where pathway inhibition via imatinib results in marked PPP impairment and an accumulation of RNA nucleotides and negative regulation of mRNA.	Pentosephosphates	81-98	mitogen-activated protein kinase 1	Homo sapiens	42-45
26248089-0	2015	MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells.	Pentosephosphates	25-42	ribose 5-phosphate isomerase A	Homo sapiens	92-96
26375672-2	2015	Recently, p73 has been shown to transcriptionally regulate selective metabolic enzymes, such as cytochrome c oxidase subunit IV isoform 1, glucose 6-phosphate dehydrogenase and glutaminase-2, resulting in significant effects on metabolism, including hepatocellular lipid metabolism, glutathione homeostasis and the pentose phosphate pathway.	Pentosephosphates	315-332	transformation related protein 73	Mus musculus	10-13
26032094-1	2015	It is well known that tumor cells mainly depend on the nonoxidative pathway of the pentose phosphate pathway (PPP), and transketolase-like 1 (TKTL1), a kind of crucial metabolism enzyme, participates in the regulation of PPP; notably, overwhelming evidence has demonstrated that TKTL1 plays pivotal roles in the development and progression of multiple tumors.	Pentosephosphates	83-100	transketolase like 1	Homo sapiens	120-140
26032094-1	2015	It is well known that tumor cells mainly depend on the nonoxidative pathway of the pentose phosphate pathway (PPP), and transketolase-like 1 (TKTL1), a kind of crucial metabolism enzyme, participates in the regulation of PPP; notably, overwhelming evidence has demonstrated that TKTL1 plays pivotal roles in the development and progression of multiple tumors.	Pentosephosphates	83-100	transketolase like 1	Homo sapiens	142-147
26032094-1	2015	It is well known that tumor cells mainly depend on the nonoxidative pathway of the pentose phosphate pathway (PPP), and transketolase-like 1 (TKTL1), a kind of crucial metabolism enzyme, participates in the regulation of PPP; notably, overwhelming evidence has demonstrated that TKTL1 plays pivotal roles in the development and progression of multiple tumors.	Pentosephosphates	83-100	transketolase like 1	Homo sapiens	279-284
26375672-2	2015	Recently, p73 has been shown to transcriptionally regulate selective metabolic enzymes, such as cytochrome c oxidase subunit IV isoform 1, glucose 6-phosphate dehydrogenase and glutaminase-2, resulting in significant effects on metabolism, including hepatocellular lipid metabolism, glutathione homeostasis and the pentose phosphate pathway.	Pentosephosphates	315-332	cytochrome c oxidase subunit 4I1	Mus musculus	96-137
26375672-4	2015	Our results show that the depletion of all p73 isoforms cause altered lysine metabolism and glycolysis, distinct patterns for glutathione synthesis and Krebs cycle, as well as an elevated pentose phosphate pathway and abnormal lipid accumulation.	Pentosephosphates	188-205	transformation related protein 73	Mus musculus	43-46
26269384-7	2015	Finally, deletion of YCA1 led to AA-PCD pathway through the activation of ceramides, whereas in the presence of the gene yeast cells underwent an AA-PCD pathway characterized by the shift of the main glycolytic pathway to the pentose phosphate pathway and a proteolytic mechanism to cope with oxidative stress.	Pentosephosphates	226-243	Ca(2+)-dependent cysteine protease MCA1	Saccharomyces cerevisiae S288C	21-25
26337086-5	2015	We also found that C13 cells not only present an increased glucose-uptake and consumption, but also exhibit increased expression and enzymatic activity of the Pentose Phosphate pathway (PPP) enzyme Glucose-6-Phosphate Dehydrogenase (G6PDH).	Pentosephosphates	159-176	glucose-6-phosphate dehydrogenase	Homo sapiens	198-231
26337086-5	2015	We also found that C13 cells not only present an increased glucose-uptake and consumption, but also exhibit increased expression and enzymatic activity of the Pentose Phosphate pathway (PPP) enzyme Glucose-6-Phosphate Dehydrogenase (G6PDH).	Pentosephosphates	159-176	glucose-6-phosphate dehydrogenase	Homo sapiens	233-238
26291555-9	2015	Elevated levels of activated G6PD consequent to PDGF-BB induction led to increased dihydronicotinamide adenine dinucleotide phosphate generation through stimulation of the pentose phosphate pathway, which enhanced VSMC viability and reduced apoptosis in vivo and in vitro via glutathione homeostasis.	Pentosephosphates	172-189	glucose-6-phosphate dehydrogenase	Homo sapiens	29-33
26539187-4	2015	Additional overexpression of genes RKI1, RPE1, TKL1, and TAL1 in the non-oxidative pentose phosphate pathway (PPP) in SyBE001 increased the xylose consumption rate by 1.19-fold.	Pentosephosphates	83-100	ribose-5-phosphate isomerase RKI1	Saccharomyces cerevisiae S288C	35-39
26539187-4	2015	Additional overexpression of genes RKI1, RPE1, TKL1, and TAL1 in the non-oxidative pentose phosphate pathway (PPP) in SyBE001 increased the xylose consumption rate by 1.19-fold.	Pentosephosphates	83-100	ribulose-phosphate 3-epimerase RPE1	Saccharomyces cerevisiae S288C	41-45
26539187-4	2015	Additional overexpression of genes RKI1, RPE1, TKL1, and TAL1 in the non-oxidative pentose phosphate pathway (PPP) in SyBE001 increased the xylose consumption rate by 1.19-fold.	Pentosephosphates	83-100	transketolase TKL1	Saccharomyces cerevisiae S288C	47-51
26539187-4	2015	Additional overexpression of genes RKI1, RPE1, TKL1, and TAL1 in the non-oxidative pentose phosphate pathway (PPP) in SyBE001 increased the xylose consumption rate by 1.19-fold.	Pentosephosphates	83-100	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1	Saccharomyces cerevisiae S288C	57-61
26329784-1	2015	Increasing evidence has demonstrated that glucose-6-phosphate dehydrogenase (G6PD), a key metabolic enzyme, participating in pentose phosphate pathway (PPP), is tightly associated with development and progression of a variety of tumors.	Pentosephosphates	125-142	glucose-6-phosphate dehydrogenase	Homo sapiens	42-75
26329784-1	2015	Increasing evidence has demonstrated that glucose-6-phosphate dehydrogenase (G6PD), a key metabolic enzyme, participating in pentose phosphate pathway (PPP), is tightly associated with development and progression of a variety of tumors.	Pentosephosphates	125-142	glucose-6-phosphate dehydrogenase	Homo sapiens	77-81
26198663-3	2015	Deficiencies in human glucose-6-phosphate dehydrogenase, the initial enzyme in the pentose phosphate pathway (PPP), lead to a disturbed redox equilibrium in infected erythrocytes and partial protection against severe malaria.	Pentosephosphates	83-100	glucose-6-phosphate dehydrogenase	Homo sapiens	22-55
26219221-8	2015	Higher TIGAR levels correlated with higher pentose phosphate pathway activity and less oxidative stress.	Pentosephosphates	43-60	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	7-12
26583321-3	2015	Here, we show that glucose-6-phosphate dehydrogenase (G6PD), the first and rate-limiting enzyme of the pentose phosphate pathway, is highly expressed in chronic hepatitis B virus (HBV)-infected human liver and HBV-associated liver cancer, together with an elevated activity of the transcription factor Nrf2.	Pentosephosphates	103-120	glucose-6-phosphate dehydrogenase	Homo sapiens	54-58
26583321-3	2015	Here, we show that glucose-6-phosphate dehydrogenase (G6PD), the first and rate-limiting enzyme of the pentose phosphate pathway, is highly expressed in chronic hepatitis B virus (HBV)-infected human liver and HBV-associated liver cancer, together with an elevated activity of the transcription factor Nrf2.	Pentosephosphates	103-120	NFE2 like bZIP transcription factor 2	Homo sapiens	302-306
26160839-4	2015	As expected, reduced level of NADPH was also observed, at least in part due to inactivation of glucose-6-phosphate dehydrogenase in pentose phosphate pathway upon HF treatment.	Pentosephosphates	132-149	glucose-6-phosphate dehydrogenase	Homo sapiens	95-128
26399441-0	2015	O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth.	Pentosephosphates	37-54	glucose-6-phosphate dehydrogenase	Homo sapiens	19-23
26198639-6	2015	Herein we demonstrate that a metabolic shift toward the pentose phosphate pathway (PPP) is necessary for NET release because glucose-6-phosphate dehydrogenase (G6PD), an important enzyme from PPP, fuels NADPH oxidase with NADPH to produce superoxide and thus induce NETs.	Pentosephosphates	56-73	glucose-6-phosphate dehydrogenase	Homo sapiens	125-158
26198639-6	2015	Herein we demonstrate that a metabolic shift toward the pentose phosphate pathway (PPP) is necessary for NET release because glucose-6-phosphate dehydrogenase (G6PD), an important enzyme from PPP, fuels NADPH oxidase with NADPH to produce superoxide and thus induce NETs.	Pentosephosphates	56-73	glucose-6-phosphate dehydrogenase	Homo sapiens	160-164
25647543-4	2015	SHPK is an enzyme that phosphorylates sedoheptulose to sedoheptulose-7-phosphate, which is an important intermediate of the pentose phosphate pathway.	Pentosephosphates	124-141	sedoheptulokinase	Homo sapiens	0-4
26555470-4	2015	It is supposed that low concentrations of hydrogen peroxide activate the pentose phosphate pathway, resulting in NADPH synthesis and the reduction of the oxidized glutathione by glutathione reductase yielding GSH.	Pentosephosphates	73-90	glutathione-disulfide reductase	Homo sapiens	178-199
26126921-0	2015	Zoledronic acid inhibits the pentose phosphate pathway through attenuating the Ras-TAp73-G6PD axis in bladder cancer cells.	Pentosephosphates	29-46	glucose-6-phosphate dehydrogenase	Homo sapiens	89-93
26551705-4	2015	The pentose phosphate pathway (PPP) is enhanced by Nrf2 in cancers and aids their growth.	Pentosephosphates	4-21	NFE2 like bZIP transcription factor 2	Homo sapiens	51-55
25934335-6	2015	Labeling of the ribose ring demonstrates that U87-MG glioma cells use the reversible branch of the non-oxidative pentose phosphate pathway.	Pentosephosphates	113-130	small nucleolar RNA, C/D box 87	Homo sapiens	46-49
26023239-1	2015	Oncogenic epidermal growth factor receptor (EGFR) signaling plays an important role in regulating global metabolic pathways, including aerobic glycolysis, the pentose phosphate pathway (PPP), and pyrimidine biosynthesis.	Pentosephosphates	159-176	epidermal growth factor receptor	Homo sapiens	10-42
25888782-1	2015	In plant cells, glucose 6 phosphate dehydrogenase (G6PDH-EC 1.1.1.49) regulates the oxidative pentose phosphate pathway (OPPP), a metabolic route involved in the production of NADPH for various biosynthetic processes and stress response.	Pentosephosphates	94-111	g6pdh	Hordeum vulgare	16-49
26023239-1	2015	Oncogenic epidermal growth factor receptor (EGFR) signaling plays an important role in regulating global metabolic pathways, including aerobic glycolysis, the pentose phosphate pathway (PPP), and pyrimidine biosynthesis.	Pentosephosphates	159-176	epidermal growth factor receptor	Homo sapiens	44-48
26394465-3	2015	In the Archean hydrothermal conditions under the action of the phosphorus chemical potential the C-H-O system was transformed into a four-component system C-H-O-P setting up a gluconeogenic system, which became the basis of power supply for a protometabolism, and formation of a new cycle of CO2 fixation (reductive pentose phosphate pathway).	Pentosephosphates	316-333	DNA damage inducible transcript 3	Homo sapiens	155-162
26205721-7	2015	Glucose-6-phosphate dehydrogenase is the first enzyme of the pentose phosphate pathway; activation of this pathway accompanies enhancement of synthetic processes, including lipid synthesis.	Pentosephosphates	61-78	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
25716920-6	2015	D-Glucose-6-phosphate (D-G6P), which is generated from D-FBP in the gluconeogenesis pathway, produces D-ribose-5-phosphate (D-R5P) in the pentose phosphate pathway.	Pentosephosphates	138-155	ECB2	Homo sapiens	57-60
25662817-3	2015	RESULTS: Analysis of LC-MSMS data showed that a large number of components, belonging to glycolysis, pentose phosphate, folding and stress response pathways, were associated with G6PDH and Adh1 putative complexes and that a number of these proteins were identical in either network in both yeasts.	Pentosephosphates	101-118	alcohol dehydrogenase ADH1	Saccharomyces cerevisiae S288C	189-193
25504008-3	2015	Nrf2, a master transcriptional regulator of redox homeostasis genes, also activates the pentose phosphate pathway, including NADPH production.	Pentosephosphates	88-105	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-4
25241892-5	2015	The altered cellular redox state caused by the loss of Pim occurred as a result of lower levels of metabolic intermediates in the glycolytic and pentose phosphate pathways as well as abnormal mitochondrial oxidative phosphorylation.	Pentosephosphates	145-162	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	55-58
26114427-9	2015	Metabolic products associated with the pentose phosphate pathway and nucleotide biosynthesis also increased in PGC-1alpha-Tg mice.	Pentosephosphates	39-56	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	111-121
25819664-5	2015	Additionally, we assessed glucose-6-phosphate dehydrogenase activity, a key enzyme in the pentose phosphate pathway (PPP).	Pentosephosphates	90-107	glucose-6-phosphate dehydrogenase	Rattus norvegicus	26-59
25980795-1	2015	Glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme involved in the pentose phosphate pathway.	Pentosephosphates	84-101	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
25980795-1	2015	Glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme involved in the pentose phosphate pathway.	Pentosephosphates	84-101	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
25945836-0	2015	Metabolomic profile of glycolysis and the pentose phosphate pathway identifies the central role of glucose-6-phosphate dehydrogenase in clear cell-renal cell carcinoma.	Pentosephosphates	42-59	glucose-6-phosphate dehydrogenase	Homo sapiens	99-132
26089981-4	2015	Transketolase is an enzyme of the pentose phosphate pathway; a novel pathway which is involved in energy generation and nucleic acid synthesis.	Pentosephosphates	34-51	transketolase	Homo sapiens	0-13
25937285-7	2015	This was due to restoration of deoxyribonucleotide triphosphate (dNTP) levels through both upregulation of the pentose phosphate pathway via increased glucose-6-phosphate dehydrogenase (G6PD) activity and enhanced glucose and glutamine consumption.	Pentosephosphates	111-128	glucose-6-phosphate dehydrogenase	Homo sapiens	151-184
25937285-7	2015	This was due to restoration of deoxyribonucleotide triphosphate (dNTP) levels through both upregulation of the pentose phosphate pathway via increased glucose-6-phosphate dehydrogenase (G6PD) activity and enhanced glucose and glutamine consumption.	Pentosephosphates	111-128	glucose-6-phosphate dehydrogenase	Homo sapiens	186-190
25928429-0	2015	TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway.	Pentosephosphates	46-62	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	0-5
25548118-2	2015	We coupled xylose utilization with glucose metabolism by deletion of D-ribulose-5-phosphate 3-epimerase (RPE1) through pentose phosphate pathway flux.	Pentosephosphates	119-136	ribulose-phosphate 3-epimerase RPE1	Saccharomyces cerevisiae S288C	105-109
25928429-1	2015	Previous study revealed that the protective effect of TIGAR in cell survival is mediated through the increase in PPP (pentose phosphate pathway) flux.	Pentosephosphates	118-135	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	54-59
25880689-7	2015	The present study demonstrates the feasibility of using CE-based IMERs for rapid and efficient on-line assay of G6PDH, an important enzyme in the pentosephosphate pathway of human metabolism.	Pentosephosphates	146-162	glucose-6-phosphate dehydrogenase	Homo sapiens	112-117
23363574-1	2015	Glucose 6-phosphate dehydrogenase (d-glucose 6-phosphate: NADP(+) oxidoreductase, EC 1.1.1.49; G6PD) is a key enzyme that is localized in all mammal tissues, especially in cytoplasmic sections and that catalyzes the first step of pentose phosphate metabolic pathway.	Pentosephosphates	230-247	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
25894462-0	2015	Multiple myeloma acquires resistance to EGFR inhibitor via induction of pentose phosphate pathway.	Pentosephosphates	72-89	epidermal growth factor receptor	Homo sapiens	40-44
25894462-3	2015	The moderate inhibitory effect was conferred by induction of pentose phosphate pathway (PPP) when cells were treated with Gefitinib, the EGFR inhibitor.	Pentosephosphates	61-78	epidermal growth factor receptor	Homo sapiens	137-141
25759513-3	2015	Furthermore, when activated in human tumors by somatic mutations, Nrf2 confers growth advantages and chemoresistance by regulating genes involved in various processes such as the pentose phosphate pathway and nucleotide synthesis in addition to antioxidant proteins.	Pentosephosphates	179-196	NFE2 like bZIP transcription factor 2	Homo sapiens	66-70
25578537-6	2015	The expression pattern of glycolytic genes (HK, PFK and G6PDH) indicated that oocytes and embryos under 5% O2 tend to follow anaerobic glycolysis and pentose phosphate pathways to support optimum embryo development.	Pentosephosphates	150-167	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	56-61
25578537-8	2015	Further, less G6PDH expression at 20% O2 was indicative of lower pentose phosphate activity.	Pentosephosphates	65-82	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	14-19
25527558-0	2015	Deletion of PHO13, encoding haloacid dehalogenase type IIA phosphatase, results in upregulation of the pentose phosphate pathway in Saccharomyces cerevisiae.	Pentosephosphates	103-120	4-nitrophenylphosphatase	Saccharomyces cerevisiae S288C	12-17
25527558-6	2015	Transcriptome sequencing analysis revealed that pho13Delta resulted in upregulation of the pentose phosphate (PP) pathway and NADPH-producing enzymes when cells were grown on glucose or xylose.	Pentosephosphates	91-108	4-nitrophenylphosphatase	Saccharomyces cerevisiae S288C	48-58
25503731-10	2015	However, under low ischemic burden, TIGAR activation induces the pentose phosphate pathway and autophagy as a protective mechanism.	Pentosephosphates	65-82	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	36-41
25605240-3	2015	HIF1alpha represents one of the principal regulators of metabolism and energetic balance in cancer cells through its regulation of glycolysis, glycogen synthesis, Krebs cycle and the pentose phosphate shunt.	Pentosephosphates	183-200	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-9
25196942-7	2015	RESULTS: At 21 days of storage, we demonstrated that cytosolic GAPDH undergoes temporary inactivation due to the formation of an intramolecular disulfide bond between the active-site Cys-152 and nearby Cys-156, a mechanism to rerouting glucose flux toward the pentose phosphate pathway.	Pentosephosphates	260-277	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	63-68
25619394-1	2015	AIM: The pentose phosphate pathway (PPP) is involved in the activity of glucose-6-phosphate dehydrogenase (G6PD) and generation of NADPH, which plays a key role in drug metabolism.	Pentosephosphates	9-26	glucose-6-phosphate dehydrogenase	Homo sapiens	72-105
25619394-1	2015	AIM: The pentose phosphate pathway (PPP) is involved in the activity of glucose-6-phosphate dehydrogenase (G6PD) and generation of NADPH, which plays a key role in drug metabolism.	Pentosephosphates	9-26	glucose-6-phosphate dehydrogenase	Homo sapiens	107-111
25528729-5	2015	R5PI is an important enzyme that acts in the pentose phosphate pathway and catalyzes the interconversion of d-ribose-5-phosphate (R5P) and d-ribulose-5-phosphate (5RP).	Pentosephosphates	45-62	ribose 5-phosphate isomerase A	Homo sapiens	0-4
25480333-5	2015	Here we demonstrate that the activity and expression of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, are increased in hypoxic PASM cells and in lungs of chronic hypoxic rats.	Pentosephosphates	130-147	glucose-6-phosphate dehydrogenase	Rattus norvegicus	56-89
25480333-5	2015	Here we demonstrate that the activity and expression of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, are increased in hypoxic PASM cells and in lungs of chronic hypoxic rats.	Pentosephosphates	130-147	glucose-6-phosphate dehydrogenase	Rattus norvegicus	91-95
24497183-1	2014	UNLABELLED: Transaldolase (TALDO) deficiency is a rare metabolic disease in the pentose phosphate pathway, which manifests as a severe, early-onset multisystem disease.	Pentosephosphates	80-97	transaldolase 1	Homo sapiens	12-25
24374014-5	2015	p53 regulates many different aspects of metabolism, including glycolysis, mitochondrial oxidative phosphorylation, pentose phosphate pathway, fatty acid synthesis and oxidation, to maintain the homeostasis of cellular metabolism, which contributes to the role of p53 in tumor suppression.	Pentosephosphates	115-132	tumor protein p53	Homo sapiens	0-3
24374014-5	2015	p53 regulates many different aspects of metabolism, including glycolysis, mitochondrial oxidative phosphorylation, pentose phosphate pathway, fatty acid synthesis and oxidation, to maintain the homeostasis of cellular metabolism, which contributes to the role of p53 in tumor suppression.	Pentosephosphates	115-132	tumor protein p53	Homo sapiens	263-266
25644430-8	2015	Conversely, among the downregulated genes, we found G6PD, the enzyme catalyzing the rate-limiting step of the pentose phosphate shunt.	Pentosephosphates	110-127	glucose-6-phosphate dehydrogenase	Homo sapiens	52-56
25512540-5	2014	PCGEM1 promotes glucose uptake for aerobic glycolysis, coupling with the pentose phosphate shunt to facilitate biosynthesis of nucleotide and lipid, and generates NADPH for redox homeostasis.	Pentosephosphates	73-90	PCGEM1 prostate-specific transcript	Homo sapiens	0-6
25512540-6	2014	We show that PCGEM1 regulates metabolism at a transcriptional level that affects multiple metabolic pathways, including glucose and glutamine metabolism, the pentose phosphate pathway, nucleotide and fatty acid biosynthesis, and the tricarboxylic acid cycle.	Pentosephosphates	158-175	PCGEM1 prostate-specific transcript	Homo sapiens	13-19
25476909-4	2014	Moreover, NADPH, generated by both the pentose phosphate pathway and the cancer-specific serine glycolytic diversion, appears to sustain glutamine utilization for amino-acid synthesis, lipid synthesis, and for ROS quenching.	Pentosephosphates	39-56	2,4-dienoyl-CoA reductase 1	Homo sapiens	10-15
25621025-2	2015	TIGAR blocks glycolysis and promotes cellular metabolism via the pentose phosphate pathway; it promotes the production of cellular nicotinamide adenine dinucleotide phosphate (NADPH), which leads to enhanced scavenging of intracellular reactive oxygen species, and inhibition of oxidative stress-induced apoptosis in normal cells.	Pentosephosphates	65-82	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	0-5
25701261-7	2015	In addition, estradiol treatment activated metabolic genes in pentose phosphate (PPP) and serine biosynthesis pathways in the insulin-primed cells while insulin priming decreased metabolic gene expression associated with glucose catabolism in the breast cancer cells.	Pentosephosphates	62-79	insulin	Homo sapiens	126-133
25701261-7	2015	In addition, estradiol treatment activated metabolic genes in pentose phosphate (PPP) and serine biosynthesis pathways in the insulin-primed cells while insulin priming decreased metabolic gene expression associated with glucose catabolism in the breast cancer cells.	Pentosephosphates	81-84	insulin	Homo sapiens	126-133
26458310-6	2015	Also, 39 common genes, like PFKP (phosphofructokinase, platelet) and DGKH-rs11616202 (diacylglycerol kinase, eta) that enriched in sub-pathways such as galactose metabolism, fructose and mannose metabolism, and pentose phosphate pathway, were identified as the lung cancer oncogenes.	Pentosephosphates	211-228	phosphofructokinase, platelet	Homo sapiens	28-32
26458310-6	2015	Also, 39 common genes, like PFKP (phosphofructokinase, platelet) and DGKH-rs11616202 (diacylglycerol kinase, eta) that enriched in sub-pathways such as galactose metabolism, fructose and mannose metabolism, and pentose phosphate pathway, were identified as the lung cancer oncogenes.	Pentosephosphates	211-228	diacylglycerol kinase eta	Homo sapiens	69-73
26458310-6	2015	Also, 39 common genes, like PFKP (phosphofructokinase, platelet) and DGKH-rs11616202 (diacylglycerol kinase, eta) that enriched in sub-pathways such as galactose metabolism, fructose and mannose metabolism, and pentose phosphate pathway, were identified as the lung cancer oncogenes.	Pentosephosphates	211-228	endothelin receptor type A	Homo sapiens	109-112
24497183-1	2014	UNLABELLED: Transaldolase (TALDO) deficiency is a rare metabolic disease in the pentose phosphate pathway, which manifests as a severe, early-onset multisystem disease.	Pentosephosphates	80-97	transaldolase 1	Homo sapiens	27-32
25121555-1	2014	The enzyme glucose-6-phosphate dehydrogenase (G6PDH) catalyzes the first step of the oxidative branch of the pentose phosphate pathway, which provides cells with NADPH, an essential cofactor for many biosynthetic pathways and antioxidizing enzymes.	Pentosephosphates	109-126	glucose-6-phosphate dehydrogenase	Homo sapiens	11-44
25121555-1	2014	The enzyme glucose-6-phosphate dehydrogenase (G6PDH) catalyzes the first step of the oxidative branch of the pentose phosphate pathway, which provides cells with NADPH, an essential cofactor for many biosynthetic pathways and antioxidizing enzymes.	Pentosephosphates	109-126	glucose-6-phosphate dehydrogenase	Homo sapiens	46-51
25437549-5	2014	DNA-damage-induced p53 interfered with chlamydial development through downregulation of the pentose phosphate pathway (PPP).	Pentosephosphates	92-109	tumor protein p53	Homo sapiens	19-22
25288790-3	2014	The pentose phosphate pathway (PPP), metabolism in the citric acid cycle, incomplete equilibration by triose phosphate isomerase, or the transaldolase reaction all interact to produce complex (13)C-labeling patterns in exported glucose.	Pentosephosphates	4-21	triosephosphate isomerase	Rattus norvegicus	102-128
25029028-7	2014	Regarding the metabolic pathways, enzymes involved in glycolysis (GAPDH/PKM2/LDH-A/LDH-B) and pentose phosphate pathway (PPP) (G6PD/TKT/6PGD) were up-regulated.	Pentosephosphates	94-111	glucose-6-phosphate dehydrogenase	Homo sapiens	127-131
25043030-9	2014	Second, in pVHL (the protein encoded by the VHL gene)-deficient ccRCC cells, FBP1 restrains cell proliferation, glycolysis and the pentose phosphate pathway in a catalytic-activity-independent manner, by inhibiting nuclear HIF function via direct interaction with the HIF inhibitory domain.	Pentosephosphates	131-148	fructose-bisphosphatase 1	Homo sapiens	77-81
25041845-3	2014	M2-type pyruvate kinase (PKM2) plays a pivotal role in sustaining aerobic glycolysis, pentose phosphate pathway and serine synthesis pathway.	Pentosephosphates	86-103	pyruvate kinase M1/2	Homo sapiens	25-29
24352616-2	2014	OBJECTIVE: To determine the molecular and biochemical mechanisms by which the PTEN/Tcl1 axis regulates the pentose phosphate pathway (PPP) in hepatocellular carcinoma (HCC).	Pentosephosphates	107-124	phosphatase and tensin homolog	Homo sapiens	78-82
24352616-2	2014	OBJECTIVE: To determine the molecular and biochemical mechanisms by which the PTEN/Tcl1 axis regulates the pentose phosphate pathway (PPP) in hepatocellular carcinoma (HCC).	Pentosephosphates	107-124	TCL1 family AKT coactivator A	Homo sapiens	83-87
25378403-2	2014	Caspase-2, an apoptotic initiator, can be suppressed by high levels of nutrient flux through the pentose phosphate pathway.	Pentosephosphates	97-114	caspase 2	Homo sapiens	0-9
25378403-6	2014	These findings may have implications for metabolic control of the many CaMKII-controlled and protein phosphatase 2A-regulated physiological processes, because both enzymes appear to be responsive to alterations in glucose metabolized via the pentose phosphate pathway.	Pentosephosphates	242-259	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	71-77
25107906-5	2014	This regulation of Nrf2 post-induction by nuclear HO-1 is important for the preferential transcription of phase II detoxification enzymes such as NQO1 as well as glucose-6-phosphate dehydrogenase (G6PDH), a regulator of the pentose phosphate pathway.	Pentosephosphates	224-241	NFE2 like bZIP transcription factor 2	Homo sapiens	19-23
25107906-5	2014	This regulation of Nrf2 post-induction by nuclear HO-1 is important for the preferential transcription of phase II detoxification enzymes such as NQO1 as well as glucose-6-phosphate dehydrogenase (G6PDH), a regulator of the pentose phosphate pathway.	Pentosephosphates	224-241	heme oxygenase 1	Homo sapiens	50-54
25107906-5	2014	This regulation of Nrf2 post-induction by nuclear HO-1 is important for the preferential transcription of phase II detoxification enzymes such as NQO1 as well as glucose-6-phosphate dehydrogenase (G6PDH), a regulator of the pentose phosphate pathway.	Pentosephosphates	224-241	NAD(P)H quinone dehydrogenase 1	Homo sapiens	146-150
25107906-5	2014	This regulation of Nrf2 post-induction by nuclear HO-1 is important for the preferential transcription of phase II detoxification enzymes such as NQO1 as well as glucose-6-phosphate dehydrogenase (G6PDH), a regulator of the pentose phosphate pathway.	Pentosephosphates	224-241	glucose-6-phosphate dehydrogenase	Homo sapiens	162-195
25107906-5	2014	This regulation of Nrf2 post-induction by nuclear HO-1 is important for the preferential transcription of phase II detoxification enzymes such as NQO1 as well as glucose-6-phosphate dehydrogenase (G6PDH), a regulator of the pentose phosphate pathway.	Pentosephosphates	224-241	glucose-6-phosphate dehydrogenase	Homo sapiens	197-202
25229745-9	2014	Finally, bioinformatics elaborations highlighted a link between patient survival rates and the co-expression of p63 and rate limiting enzymes of the pentose phosphate pathway, G6PD and PGD.	Pentosephosphates	149-166	tumor protein p63	Homo sapiens	112-115
25229745-9	2014	Finally, bioinformatics elaborations highlighted a link between patient survival rates and the co-expression of p63 and rate limiting enzymes of the pentose phosphate pathway, G6PD and PGD.	Pentosephosphates	149-166	glucose-6-phosphate dehydrogenase	Homo sapiens	176-180
24993821-5	2014	We used in vitro and in vivo metabolic profiling with [(13)C]glucose tracers to investigate the contribution of AMPK to core glucose metabolism in MDA-MB-231 cells, which have a Warburg metabolic phenotype; these experiments indicated that AMPK supports tumor glucose metabolism in part through positive regulation of glycolysis and the nonoxidative pentose phosphate cycle.	Pentosephosphates	350-367	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	240-244
25046111-7	2014	On the other hand, MAPK14 mediates a metabolic shift from glycolysis to the pentose phosphate pathway (PPP) through the modulation of PFKFB3 (6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase 3) degradation by the proteasome.	Pentosephosphates	76-93	mitogen-activated protein kinase 14	Homo sapiens	19-25
25046111-7	2014	On the other hand, MAPK14 mediates a metabolic shift from glycolysis to the pentose phosphate pathway (PPP) through the modulation of PFKFB3 (6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase 3) degradation by the proteasome.	Pentosephosphates	76-93	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	134-140
25046111-7	2014	On the other hand, MAPK14 mediates a metabolic shift from glycolysis to the pentose phosphate pathway (PPP) through the modulation of PFKFB3 (6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase 3) degradation by the proteasome.	Pentosephosphates	76-93	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	142-196
24203292-10	2014	On the other hand, protein synthesis of G6PD and TKT, enzymes critical for pentose phosphate pathway (PPP), was increased (in 45 and 55 % of patients, respectively), while that of ALDOA, an enzyme for mainstream glycolysis, was eliminated (in 55 % of patients).	Pentosephosphates	75-92	glucose-6-phosphate dehydrogenase	Homo sapiens	40-44
24203292-10	2014	On the other hand, protein synthesis of G6PD and TKT, enzymes critical for pentose phosphate pathway (PPP), was increased (in 45 and 55 % of patients, respectively), while that of ALDOA, an enzyme for mainstream glycolysis, was eliminated (in 55 % of patients).	Pentosephosphates	75-92	transketolase	Homo sapiens	49-52
24990892-0	2014	Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury.	Pentosephosphates	30-47	epidermal growth factor receptor	Mus musculus	79-83
24990892-0	2014	Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury.	Pentosephosphates	30-47	thymoma viral proto-oncogene 1	Mus musculus	84-87
24981175-3	2014	Here we demonstrate that amino acids via mammalian target of rapamycin 2 and IkappaB kinase regulate Akt activity and Akt association and phosphorylation of transketolase (TKT), a key enzyme of the nonoxidative pentose phosphate pathway (PPP).	Pentosephosphates	211-228	transketolase	Homo sapiens	157-170
25713697-5	2014	G6PD catalyses the first step of the pentose phosphate pathway and enzyme variants, frequent in some populations have been selected because they confer resistance to malaria, are associated with hemolysis in the presence of oxidizing agents including several drugs.	Pentosephosphates	37-54	glucose-6-phosphate dehydrogenase	Homo sapiens	0-4
24981175-3	2014	Here we demonstrate that amino acids via mammalian target of rapamycin 2 and IkappaB kinase regulate Akt activity and Akt association and phosphorylation of transketolase (TKT), a key enzyme of the nonoxidative pentose phosphate pathway (PPP).	Pentosephosphates	211-228	transketolase	Homo sapiens	172-175
24872551-1	2014	TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits glycolysis and increases the flow of pentose phosphate pathway (PPP), which generates NADPH and pentose.	Pentosephosphates	102-119	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	0-47
24954297-2	2014	Using enzymes from the pentose phosphate pathway, we coupled chemically synthesized uracil nucleobase with specifically (13) C-labeled ribose to synthesize both UTP and CTP in nearly quantitative yields.	Pentosephosphates	23-40	solute carrier family 25 member 1	Homo sapiens	169-172
24929815-1	2014	Glucose 6-phosphate dehydrogenase (G6PD), the first and the rate-limiting enzyme in the pentose phosphate pathway (PPP), catalyzes the oxidation of G6P to 6-phosphogluconolactone and the reduction of NADP(+) to NADPH.	Pentosephosphates	88-105	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
24929815-1	2014	Glucose 6-phosphate dehydrogenase (G6PD), the first and the rate-limiting enzyme in the pentose phosphate pathway (PPP), catalyzes the oxidation of G6P to 6-phosphogluconolactone and the reduction of NADP(+) to NADPH.	Pentosephosphates	88-105	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
24252052-1	2014	OBJECTIVE: Glucose-6-phosphate dehydrogenase (G6PD) is an important site of metabolic control in the pentose phosphate pathway.	Pentosephosphates	101-118	glucose-6-phosphate dehydrogenase	Homo sapiens	11-44
24252052-1	2014	OBJECTIVE: Glucose-6-phosphate dehydrogenase (G6PD) is an important site of metabolic control in the pentose phosphate pathway.	Pentosephosphates	101-118	glucose-6-phosphate dehydrogenase	Homo sapiens	46-50
24769394-1	2014	Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway (PPP) and plays an essential role in the oxidative stress response by producing NADPH, the main intracellular reductant.	Pentosephosphates	64-81	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
24769394-1	2014	Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway (PPP) and plays an essential role in the oxidative stress response by producing NADPH, the main intracellular reductant.	Pentosephosphates	64-81	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
24769394-1	2014	Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway (PPP) and plays an essential role in the oxidative stress response by producing NADPH, the main intracellular reductant.	Pentosephosphates	64-81	2,4-dienoyl-CoA reductase 1	Homo sapiens	170-175
24825350-0	2014	SIRT2 controls the pentose phosphate switch.	Pentosephosphates	19-36	sirtuin 2	Homo sapiens	0-5
24747137-6	2014	Transketolase activity (pentose phosphate pathway [PPP] marker) did not change.	Pentosephosphates	24-41	transketolase	Homo sapiens	0-13
24861463-0	2014	Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth.	Pentosephosphates	18-35	androgen receptor	Homo sapiens	50-67
24861463-0	2014	Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth.	Pentosephosphates	18-35	mechanistic target of rapamycin kinase	Homo sapiens	68-72
24861463-5	2014	Correspondingly, clinical data suggest glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, is upregulated in prostate cancer.	Pentosephosphates	113-130	glucose-6-phosphate dehydrogenase	Homo sapiens	39-72
24861463-5	2014	Correspondingly, clinical data suggest glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, is upregulated in prostate cancer.	Pentosephosphates	113-130	glucose-6-phosphate dehydrogenase	Homo sapiens	74-78
24861463-6	2014	We hypothesized that androgen receptor (AR) signaling, which plays an essential role in the disease, mediated prostate cancer cell growth in part by increasing flux through the pentose phosphate pathway.	Pentosephosphates	177-194	androgen receptor	Homo sapiens	21-38
24861463-6	2014	We hypothesized that androgen receptor (AR) signaling, which plays an essential role in the disease, mediated prostate cancer cell growth in part by increasing flux through the pentose phosphate pathway.	Pentosephosphates	177-194	androgen receptor	Homo sapiens	40-42
24861463-10	2014	Mechanistically, regulation of G6PD via AR in both hormone-sensitive and castration-resistant models of prostate cancer was abolished following rapamycin treatment, indicating that AR increased flux through the pentose phosphate pathway by the mammalian target of rapamycin (mTOR)-mediated upregulation of G6PD.	Pentosephosphates	211-228	glucose-6-phosphate dehydrogenase	Homo sapiens	31-35
24861463-10	2014	Mechanistically, regulation of G6PD via AR in both hormone-sensitive and castration-resistant models of prostate cancer was abolished following rapamycin treatment, indicating that AR increased flux through the pentose phosphate pathway by the mammalian target of rapamycin (mTOR)-mediated upregulation of G6PD.	Pentosephosphates	211-228	androgen receptor	Homo sapiens	40-42
24861463-10	2014	Mechanistically, regulation of G6PD via AR in both hormone-sensitive and castration-resistant models of prostate cancer was abolished following rapamycin treatment, indicating that AR increased flux through the pentose phosphate pathway by the mammalian target of rapamycin (mTOR)-mediated upregulation of G6PD.	Pentosephosphates	211-228	androgen receptor	Homo sapiens	181-183
24861463-10	2014	Mechanistically, regulation of G6PD via AR in both hormone-sensitive and castration-resistant models of prostate cancer was abolished following rapamycin treatment, indicating that AR increased flux through the pentose phosphate pathway by the mammalian target of rapamycin (mTOR)-mediated upregulation of G6PD.	Pentosephosphates	211-228	mechanistic target of rapamycin kinase	Homo sapiens	244-273
24861463-10	2014	Mechanistically, regulation of G6PD via AR in both hormone-sensitive and castration-resistant models of prostate cancer was abolished following rapamycin treatment, indicating that AR increased flux through the pentose phosphate pathway by the mammalian target of rapamycin (mTOR)-mediated upregulation of G6PD.	Pentosephosphates	211-228	mechanistic target of rapamycin kinase	Homo sapiens	275-279
24861463-10	2014	Mechanistically, regulation of G6PD via AR in both hormone-sensitive and castration-resistant models of prostate cancer was abolished following rapamycin treatment, indicating that AR increased flux through the pentose phosphate pathway by the mammalian target of rapamycin (mTOR)-mediated upregulation of G6PD.	Pentosephosphates	211-228	glucose-6-phosphate dehydrogenase	Homo sapiens	306-310
24861463-13	2014	Taken together, our data suggest that AR signaling can promote prostate cancer through the upregulation of G6PD and therefore, the flux of sugars through the pentose phosphate pathway.	Pentosephosphates	158-175	androgen receptor	Homo sapiens	38-40
24861463-13	2014	Taken together, our data suggest that AR signaling can promote prostate cancer through the upregulation of G6PD and therefore, the flux of sugars through the pentose phosphate pathway.	Pentosephosphates	158-175	glucose-6-phosphate dehydrogenase	Homo sapiens	107-111
24739386-8	2014	Stable isotope tracer analysis further demonstrated that deficiency of Nmnat3 resulted in glycolysis stall and a shift to the pentose phosphate pathway.	Pentosephosphates	126-143	nicotinamide nucleotide adenylyltransferase 3	Mus musculus	71-77
24872551-1	2014	TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits glycolysis and increases the flow of pentose phosphate pathway (PPP), which generates NADPH and pentose.	Pentosephosphates	102-119	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	49-54
24872551-1	2014	TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits glycolysis and increases the flow of pentose phosphate pathway (PPP), which generates NADPH and pentose.	Pentosephosphates	102-119	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	151-156
24832603-8	2014	Expression array study identified estradiol-enhanced transcript levels of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway.	Pentosephosphates	148-165	glucose-6-phosphate dehydrogenase 2	Mus musculus	74-107
24832603-8	2014	Expression array study identified estradiol-enhanced transcript levels of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway.	Pentosephosphates	148-165	glucose-6-phosphate dehydrogenase 2	Mus musculus	109-113
24832603-11	2014	Collectively, these data indicate that estradiol promotes glucose metabolism in mTORC1 hyperactive cells through the pentose phosphate pathway via Akt reactivation and G6PD upregulation, thereby enhancing cell survival under oxidative stress.	Pentosephosphates	117-134	CREB regulated transcription coactivator 1	Mus musculus	80-86
24832603-11	2014	Collectively, these data indicate that estradiol promotes glucose metabolism in mTORC1 hyperactive cells through the pentose phosphate pathway via Akt reactivation and G6PD upregulation, thereby enhancing cell survival under oxidative stress.	Pentosephosphates	117-134	thymoma viral proto-oncogene 1	Mus musculus	147-150
24832603-11	2014	Collectively, these data indicate that estradiol promotes glucose metabolism in mTORC1 hyperactive cells through the pentose phosphate pathway via Akt reactivation and G6PD upregulation, thereby enhancing cell survival under oxidative stress.	Pentosephosphates	117-134	glucose-6-phosphate dehydrogenase 2	Mus musculus	168-172
24632713-3	2014	The present results demonstrate that GO-203 and BTZ synergistically downregulate expression of the p53-inducible regulator of glycolysis and apoptosis (TIGAR), which promotes shunting of glucose-6-phosphate into the pentose phosphate pathway to generate reduced glutathione (GSH).	Pentosephosphates	216-233	tumor protein p53	Homo sapiens	99-102
24832603-0	2014	Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells.	Pentosephosphates	19-36	thymoma viral proto-oncogene 1	Mus musculus	93-96
24832603-0	2014	Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells.	Pentosephosphates	19-36	CREB regulated transcription coactivator 1	Mus musculus	100-106
24832603-4	2014	Using metabolomic profiling, we identified an estradiol-enhanced pentose phosphate pathway signature in Tsc2-deficient cells.	Pentosephosphates	65-82	TSC complex subunit 2	Mus musculus	104-108
24632713-3	2014	The present results demonstrate that GO-203 and BTZ synergistically downregulate expression of the p53-inducible regulator of glycolysis and apoptosis (TIGAR), which promotes shunting of glucose-6-phosphate into the pentose phosphate pathway to generate reduced glutathione (GSH).	Pentosephosphates	216-233	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	152-157
24599681-3	2014	The pentose phosphate pathway enzymes, which are glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase, produce nicotinamide adenine dinucleotide phosphate (NADPH) that enables cells to counterbalance the oxidative stress via the action of the glutathione system.	Pentosephosphates	4-21	glucose-6-phosphate dehydrogenase	Rattus norvegicus	49-82
24659479-6	2014	We demonstrated an increased amount of glucose flux in the glycolysis pathway, as well as the pentose phosphate pathway (PPP) upon p52 activation.	Pentosephosphates	94-111	nuclear factor kappa B subunit 2	Homo sapiens	131-134