PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 30866453-7 2019 Supplementing the cells with Ang-1 was found to protect them against the anti-CSC effect of gamma-T3. gamma-t3 92-100 angiopoietin 1 Homo sapiens 29-34 34908071-9 2022 Our data demonstrated that gamma-T3 can target beta-catenin to enhance the Wnt/beta-catenin signaling pathway, which led to increased expressions of the downstream cell proliferation and cell cycle-associated (cyclin D1 and c-myc), and cell differentiation-associated (BMP-2 and BMP-4) target genes, and ultimately promoted MC3T3-E1 cell proliferation and differentiation. gamma-t3 27-35 catenin (cadherin associated protein), beta 1 Mus musculus 79-91 34908071-9 2022 Our data demonstrated that gamma-T3 can target beta-catenin to enhance the Wnt/beta-catenin signaling pathway, which led to increased expressions of the downstream cell proliferation and cell cycle-associated (cyclin D1 and c-myc), and cell differentiation-associated (BMP-2 and BMP-4) target genes, and ultimately promoted MC3T3-E1 cell proliferation and differentiation. gamma-t3 27-35 cyclin D1 Mus musculus 210-219 34908071-9 2022 Our data demonstrated that gamma-T3 can target beta-catenin to enhance the Wnt/beta-catenin signaling pathway, which led to increased expressions of the downstream cell proliferation and cell cycle-associated (cyclin D1 and c-myc), and cell differentiation-associated (BMP-2 and BMP-4) target genes, and ultimately promoted MC3T3-E1 cell proliferation and differentiation. gamma-t3 27-35 bone morphogenetic protein 2 Mus musculus 269-274 34908071-9 2022 Our data demonstrated that gamma-T3 can target beta-catenin to enhance the Wnt/beta-catenin signaling pathway, which led to increased expressions of the downstream cell proliferation and cell cycle-associated (cyclin D1 and c-myc), and cell differentiation-associated (BMP-2 and BMP-4) target genes, and ultimately promoted MC3T3-E1 cell proliferation and differentiation. gamma-t3 27-35 bone morphogenetic protein 4 Mus musculus 279-284 30769052-4 2019 In this study, we found that gamma-T3 interacts with mitochondrial electron transfer chain NDUFB8 (a subunit of complex I) and SDHB (a subunit of complex II) and inhibits oxidative phosphorylation (OXPHOS), and triggers the production of reactive oxygen species (ROS). gamma-t3 29-37 NADH:ubiquinone oxidoreductase subunit B8 Homo sapiens 91-97 30769052-4 2019 In this study, we found that gamma-T3 interacts with mitochondrial electron transfer chain NDUFB8 (a subunit of complex I) and SDHB (a subunit of complex II) and inhibits oxidative phosphorylation (OXPHOS), and triggers the production of reactive oxygen species (ROS). gamma-t3 29-37 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 127-131 30769052-7 2019 The inhibition of NDUFB8 and SDHB by gamma-T3 led to the overproduction of ROS and the depletion of ATP, which may be responsible for inducing apoptosis in cancer cells. gamma-t3 37-45 NADH:ubiquinone oxidoreductase subunit B8 Homo sapiens 18-24 30769052-7 2019 The inhibition of NDUFB8 and SDHB by gamma-T3 led to the overproduction of ROS and the depletion of ATP, which may be responsible for inducing apoptosis in cancer cells. gamma-t3 37-45 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 29-33 9618265-1 1998 gamma-Tocotrienol (gamma-T3), a HMG CoA reductase inhibitor, was previously shown to stimulate the intracellular degradation of apolipoprotein B (apoB) in HepG2 cells. gamma-t3 19-27 apolipoprotein B Homo sapiens 128-144 9618265-1 1998 gamma-Tocotrienol (gamma-T3), a HMG CoA reductase inhibitor, was previously shown to stimulate the intracellular degradation of apolipoprotein B (apoB) in HepG2 cells. gamma-t3 19-27 apolipoprotein B Homo sapiens 146-150 9618265-7 1998 When chased for 2h, ER degradation of apoB was observed and was further enhanced in the presence of gamma-T3 versus untreated control, in spite of proteasome inhibition. gamma-t3 100-108 apolipoprotein B Homo sapiens 38-42 34908071-5 2022 gamma-T3 at 4 muM stimulated the Wnt/beta-catenin signaling pathway by increasing the expression and nuclear accumulation of beta-catenin, and the expressions of their downstream factors, such as cyclin-D1, c-Myc, BMP2 and BMP-4 in MC3T3-E1 cells. gamma-t3 0-8 catenin (cadherin associated protein), beta 1 Mus musculus 37-49 34908071-5 2022 gamma-T3 at 4 muM stimulated the Wnt/beta-catenin signaling pathway by increasing the expression and nuclear accumulation of beta-catenin, and the expressions of their downstream factors, such as cyclin-D1, c-Myc, BMP2 and BMP-4 in MC3T3-E1 cells. gamma-t3 0-8 catenin (cadherin associated protein), beta 1 Mus musculus 125-137 34908071-5 2022 gamma-T3 at 4 muM stimulated the Wnt/beta-catenin signaling pathway by increasing the expression and nuclear accumulation of beta-catenin, and the expressions of their downstream factors, such as cyclin-D1, c-Myc, BMP2 and BMP-4 in MC3T3-E1 cells. gamma-t3 0-8 cyclin D1 Mus musculus 196-205 34908071-5 2022 gamma-T3 at 4 muM stimulated the Wnt/beta-catenin signaling pathway by increasing the expression and nuclear accumulation of beta-catenin, and the expressions of their downstream factors, such as cyclin-D1, c-Myc, BMP2 and BMP-4 in MC3T3-E1 cells. gamma-t3 0-8 bone morphogenetic protein 2 Mus musculus 214-218 34908071-5 2022 gamma-T3 at 4 muM stimulated the Wnt/beta-catenin signaling pathway by increasing the expression and nuclear accumulation of beta-catenin, and the expressions of their downstream factors, such as cyclin-D1, c-Myc, BMP2 and BMP-4 in MC3T3-E1 cells. gamma-t3 0-8 bone morphogenetic protein 4 Mus musculus 223-228 34908071-6 2022 gamma-T3 not only upregulated the viability, induced G0/G1 to the S phase, and promoted the expressions of PCNA (Proliferating Cell Nuclear Antigen) and Ki-67, but also increased ALP activity and the expressions of ON, OPN and OCN. gamma-t3 0-8 proliferating cell nuclear antigen Mus musculus 107-111 34908071-6 2022 gamma-T3 not only upregulated the viability, induced G0/G1 to the S phase, and promoted the expressions of PCNA (Proliferating Cell Nuclear Antigen) and Ki-67, but also increased ALP activity and the expressions of ON, OPN and OCN. gamma-t3 0-8 proliferating cell nuclear antigen Mus musculus 113-147 34908071-6 2022 gamma-T3 not only upregulated the viability, induced G0/G1 to the S phase, and promoted the expressions of PCNA (Proliferating Cell Nuclear Antigen) and Ki-67, but also increased ALP activity and the expressions of ON, OPN and OCN. gamma-t3 0-8 antigen identified by monoclonal antibody Ki 67 Mus musculus 153-158 34908071-6 2022 gamma-T3 not only upregulated the viability, induced G0/G1 to the S phase, and promoted the expressions of PCNA (Proliferating Cell Nuclear Antigen) and Ki-67, but also increased ALP activity and the expressions of ON, OPN and OCN. gamma-t3 0-8 alopecia, recessive Mus musculus 179-182 34908071-6 2022 gamma-T3 not only upregulated the viability, induced G0/G1 to the S phase, and promoted the expressions of PCNA (Proliferating Cell Nuclear Antigen) and Ki-67, but also increased ALP activity and the expressions of ON, OPN and OCN. gamma-t3 0-8 secreted acidic cysteine rich glycoprotein Mus musculus 215-217 34908071-6 2022 gamma-T3 not only upregulated the viability, induced G0/G1 to the S phase, and promoted the expressions of PCNA (Proliferating Cell Nuclear Antigen) and Ki-67, but also increased ALP activity and the expressions of ON, OPN and OCN. gamma-t3 0-8 secreted phosphoprotein 1 Mus musculus 219-222 34908071-8 2022 Notably, all these effects of gamma-T3 on the MC3T3-E1 cells were completely blocked by the Wnt/beta-catenin signaling pathway inhibitor XAV-939. gamma-t3 30-38 catenin (cadherin associated protein), beta 1 Mus musculus 96-108 34908071-9 2022 Our data demonstrated that gamma-T3 can target beta-catenin to enhance the Wnt/beta-catenin signaling pathway, which led to increased expressions of the downstream cell proliferation and cell cycle-associated (cyclin D1 and c-myc), and cell differentiation-associated (BMP-2 and BMP-4) target genes, and ultimately promoted MC3T3-E1 cell proliferation and differentiation. gamma-t3 27-35 catenin (cadherin associated protein), beta 1 Mus musculus 47-59 26046324-3 2015 Therefore, the objective of this study was to determine the anti-proliferative effect of gamma-tocotrienol (gamma-T3) and 6-gingerol (6G) in combination by evaluating apoptosis and active caspase-3 in HT-29 and SW837 colorectal cancer cells. gamma-t3 108-116 caspase 3 Homo sapiens 188-197 27055589-6 2016 The co-treatment with gamma-T3 and baicalein enhanced the anti-proliferative activity of baicalein, accompanied by the downstream events of AhR-activation induced by baicalein. gamma-t3 22-30 aryl hydrocarbon receptor Homo sapiens 140-143 30562020-6 2019 The results showed that gamma-T3 significantly inhibited the cell proliferation and attenuated the NF-kappaB activity in vitro and in vivo. gamma-t3 24-32 nuclear factor kappa B subunit 1 Homo sapiens 99-108 29901169-4 2018 In light of these data, our study aimed to validate whether the inhibitory actions of gamma-T3 could be achieved by downregulation of COX-2 activity in vitro. gamma-t3 86-94 prostaglandin-endoperoxide synthase 2 Homo sapiens 134-139 29901169-7 2018 The results revealed that gamma-T3 exerted significant inhibitory effects on proliferation, migration, invasion and COX-2 protein expression, as well as on exocrine functions of MMP-2 and MMP-9 in SGC-7901 and MGC-803 cells. gamma-t3 26-34 prostaglandin-endoperoxide synthase 2 Homo sapiens 116-121 29901169-7 2018 The results revealed that gamma-T3 exerted significant inhibitory effects on proliferation, migration, invasion and COX-2 protein expression, as well as on exocrine functions of MMP-2 and MMP-9 in SGC-7901 and MGC-803 cells. gamma-t3 26-34 matrix metallopeptidase 2 Homo sapiens 178-183 29901169-7 2018 The results revealed that gamma-T3 exerted significant inhibitory effects on proliferation, migration, invasion and COX-2 protein expression, as well as on exocrine functions of MMP-2 and MMP-9 in SGC-7901 and MGC-803 cells. gamma-t3 26-34 matrix metallopeptidase 9 Homo sapiens 188-193 23879968-3 2013 gamma-T3 was necessary for endoplasmic reticulum stress markers CHOP and GRP78, whereas an intrinsic apoptotic marker, caspase 3 activation was induced only in the presence of statins. gamma-t3 0-8 DNA damage inducible transcript 3 Homo sapiens 64-68 24668775-3 2014 In searching a potential mechanism, we identified that gamma-T3 promoted two catabolic signaling pathways: (i) AMP kinase (AMPK), and (ii) enhanced autophagy, as assessed by autophagic flux and cytosolic autophagosome (LC3II) accumulation. gamma-t3 55-63 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 111-121 24668775-3 2014 In searching a potential mechanism, we identified that gamma-T3 promoted two catabolic signaling pathways: (i) AMP kinase (AMPK), and (ii) enhanced autophagy, as assessed by autophagic flux and cytosolic autophagosome (LC3II) accumulation. gamma-t3 55-63 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 123-127 24668775-4 2014 In addition, chronic exposure of gamma-T3 induced caspase3-mediated apoptotic cell death. gamma-t3 33-41 caspase 3 Homo sapiens 50-58 23879968-3 2013 gamma-T3 was necessary for endoplasmic reticulum stress markers CHOP and GRP78, whereas an intrinsic apoptotic marker, caspase 3 activation was induced only in the presence of statins. gamma-t3 0-8 heat shock protein family A (Hsp70) member 5 Homo sapiens 73-78 20617516-6 2011 Here, we demonstrate for the first time that gamma-T3 can downregulate the expression of prostate CSC markers (CD133/CD44) in androgen-independent prostate cancer cell lines (PC-3 and DU145), as evident from Western blotting analysis. gamma-t3 45-53 prominin 1 Homo sapiens 111-116 21429729-5 2012 In the present study, we demonstrate that gamma-T3 induces apoptosis in MDA-MB 231 and MCF-7 breast cancer cells as evident by PARP cleavage and caspase-7 activation. gamma-t3 42-50 collagen type XI alpha 2 chain Homo sapiens 127-131 21429729-5 2012 In the present study, we demonstrate that gamma-T3 induces apoptosis in MDA-MB 231 and MCF-7 breast cancer cells as evident by PARP cleavage and caspase-7 activation. gamma-t3 42-50 caspase 7 Homo sapiens 145-154 23727646-6 2013 In the present study, we elucidated the effect of gamma-T3 on lipid levels and lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6. gamma-T3 showed attenuation of TG through effect on fatty acid synthase, sterol regulatory element-binding transcription factor 1, stearoyl CoA desaturase 1, and carnitine palmitoyl transferase 1A gene expression in Hepa 1-6. gamma-t3 50-58 fatty acid synthase Mus musculus 202-221 20617516-6 2011 Here, we demonstrate for the first time that gamma-T3 can downregulate the expression of prostate CSC markers (CD133/CD44) in androgen-independent prostate cancer cell lines (PC-3 and DU145), as evident from Western blotting analysis. gamma-t3 45-53 CD44 molecule (Indian blood group) Homo sapiens 117-121 20207946-9 2010 Comparable findings were obtained when Madin-Darby canine kidney II cells that express endogenous NPC1L1 were incubated with increasing concentrations of gamma-T3 or gamma-T3 with increasing concentrations of ezetimibe. gamma-t3 154-162 NPC1-like intracellular cholesterol transporter 1 Canis lupus familiaris 98-104 20682650-3 2010 Results from esterase staining, colony formation, caspase activation, and sub-G(1) cell cycle arrest revealed that gamma-T3 can sensitize human colon cancer cells to TRAIL. gamma-t3 115-123 TNF superfamily member 10 Homo sapiens 166-171 20682650-5 2010 We also found that gamma-T3, but not tocopherol, induced the expression of the TRAIL receptors death receptor (DR)-4 and DR5. gamma-t3 19-27 TNF superfamily member 10 Homo sapiens 79-84 20207946-9 2010 Comparable findings were obtained when Madin-Darby canine kidney II cells that express endogenous NPC1L1 were incubated with increasing concentrations of gamma-T3 or gamma-T3 with increasing concentrations of ezetimibe. gamma-t3 166-174 NPC1-like intracellular cholesterol transporter 1 Canis lupus familiaris 98-104 16517139-4 2006 In addition, gamma-T3 stimulated a rise in caspase-8 and caspase-9 activities. gamma-t3 13-21 caspase 8 Homo sapiens 43-52 16517139-4 2006 In addition, gamma-T3 stimulated a rise in caspase-8 and caspase-9 activities. gamma-t3 13-21 caspase 9 Homo sapiens 57-66 16517139-5 2006 We also found that gamma-T3-induced apoptotic cell death was accompanied by up-regulation of Bax and a rise in the fragments of Bid and caspase-8. gamma-t3 19-27 BCL2 associated X, apoptosis regulator Homo sapiens 93-96 16517139-5 2006 We also found that gamma-T3-induced apoptotic cell death was accompanied by up-regulation of Bax and a rise in the fragments of Bid and caspase-8. gamma-t3 19-27 BH3 interacting domain death agonist Homo sapiens 128-131 16517139-5 2006 We also found that gamma-T3-induced apoptotic cell death was accompanied by up-regulation of Bax and a rise in the fragments of Bid and caspase-8. gamma-t3 19-27 caspase 8 Homo sapiens 136-145