PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
22997289-10	2012	Inhibition of CD73 activity with AMPCP in living mouse eyes resulted in a significant decrease in outflow facility.	alpha,beta-methyleneadenosine 5'-diphosphate	33-38	5' nucleotidase, ecto	Mus musculus	14-18
21918191-9	2011	Pharmacological inactivation of CD73 in WT mice using alpha, beta-methylene ADP augmented cytokine levels in the blood and peritoneal lavage fluid.	alpha,beta-methyleneadenosine 5'-diphosphate	54-79	5' nucleotidase, ecto	Mus musculus	32-36
22826317-3	2012	In this study, we demonstrate that administration of a specific CD73 inhibitor, adenosine 5"-(alpha,beta-methylene)diphosphate (APCP), to melanoma-bearing mice induced a significant tumor regression by promoting the release of Th1- and Th17-associated cytokines in the tumor microenvironment.	alpha,beta-methyleneadenosine 5'-diphosphate	80-126	5' nucleotidase, ecto	Mus musculus	64-68
22826317-3	2012	In this study, we demonstrate that administration of a specific CD73 inhibitor, adenosine 5"-(alpha,beta-methylene)diphosphate (APCP), to melanoma-bearing mice induced a significant tumor regression by promoting the release of Th1- and Th17-associated cytokines in the tumor microenvironment.	alpha,beta-methyleneadenosine 5'-diphosphate	80-126	negative elongation factor complex member C/D, Th1l	Mus musculus	227-230
21469131-7	2011	Pharmacological inhibition of CD73 with alpha,beta-methylene-adenosine-5"-diphosphate in WT mice retarded tumor progression similarly to the genetic deletion of CD73.	alpha,beta-methyleneadenosine 5'-diphosphate	40-85	5' nucleotidase, ecto	Mus musculus	30-34
21741987-3	2011	Thus, the present study investigates the effects of NPS on locomotor activity in mice treated with or without alpha,beta-methylene adenosine 5"-diphosphate (AOPCP), the inhibitor of ecto-5"-nucleotidase.	alpha,beta-methyleneadenosine 5'-diphosphate	110-155	5' nucleotidase, ecto	Mus musculus	182-202
21741987-3	2011	Thus, the present study investigates the effects of NPS on locomotor activity in mice treated with or without alpha,beta-methylene adenosine 5"-diphosphate (AOPCP), the inhibitor of ecto-5"-nucleotidase.	alpha,beta-methyleneadenosine 5'-diphosphate	157-162	5' nucleotidase, ecto	Mus musculus	182-202
20458493-7	2010	The enzyme was identified by immunological techniques and by in situ enzymatic assays, including inhibition experiments with alpha,beta-methylene-ADP, a specific CD73 inhibitor.	alpha,beta-methyleneadenosine 5'-diphosphate	125-149	5' nucleotidase, ecto	Mus musculus	162-166
18404437-7	2007	Ecto-5"-nucleotidase was susceptible to inhibition by zinc acetate and by alpha,beta-methylene-adenosine diphosphate (alpha,beta-methylene-ADP).	alpha,beta-methyleneadenosine 5'-diphosphate	74-116	5'-nucleotidase ecto	Homo sapiens	0-20
20398264-4	2010	Recombinant mNT5E hydrolyzed AMP in biochemical assays and was inhibited by alpha,beta-methylene-adenosine 5"-diphosphate (alpha,beta-me-ADP; IC50 = 0.43 microM), a selective inhibitor of NT5E.	alpha,beta-methyleneadenosine 5'-diphosphate	76-121	5' nucleotidase, ecto	Mus musculus	12-17
20398264-4	2010	Recombinant mNT5E hydrolyzed AMP in biochemical assays and was inhibited by alpha,beta-methylene-adenosine 5"-diphosphate (alpha,beta-me-ADP; IC50 = 0.43 microM), a selective inhibitor of NT5E.	alpha,beta-methyleneadenosine 5'-diphosphate	76-121	5' nucleotidase, ecto	Mus musculus	13-17
19074640-7	2009	alpha,beta-Methylene ADP (100 microM), an inhibitor of CD39, restored ATP-induced vasoconstriction in arterioles from mice with DSS-induced colitis.	alpha,beta-methyleneadenosine 5'-diphosphate	0-24	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	55-59
19729987-6	2009	A pronounced inhibition of 5"-AMP-induced adenosine formation by the CD73 inhibitor AMP-CP confirmed the involvement of CD73.	alpha,beta-methyleneadenosine 5'-diphosphate	84-90	5'-nucleotidase ecto	Homo sapiens	69-73
18825744-5	2008	Importantly, this reduction can be reversed using alpha,beta-methyleneadenosine-5"-diphosphate, a specific inhibitor of ecto-5"-nucleotidase.	alpha,beta-methyleneadenosine 5'-diphosphate	50-94	5'-nucleotidase ecto	Homo sapiens	120-140
18322237-6	2008	Likewise, enteral administration of the selective CD73 inhibitor alpha,beta-methylene ADP to cd73(+/+) mice resulted in a similar increase in severity of TNBS colitis.	alpha,beta-methyleneadenosine 5'-diphosphate	65-89	5' nucleotidase, ecto	Mus musculus	50-54
18322237-6	2008	Likewise, enteral administration of the selective CD73 inhibitor alpha,beta-methylene ADP to cd73(+/+) mice resulted in a similar increase in severity of TNBS colitis.	alpha,beta-methyleneadenosine 5'-diphosphate	65-89	5' nucleotidase, ecto	Mus musculus	93-97
17878054-2	2007	alpha,beta-methylene-ADP, an ecto-5"-nucleotidase inhibitor, suppressed the hydrolysis of AMP and reversed the inhibition of cell growth induced by AMP but not by adenosine.	alpha,beta-methyleneadenosine 5'-diphosphate	0-24	5'-nucleotidase ecto	Homo sapiens	29-49
17855480-4	2007	Because the ecto-5-nucleotidase (CD73, conversion of AMP to adenosine) is considered the pacemaker of extracellular adenosine generation, we first tested the effect of blocking extracellular adenosine generation with the specific CD73-inhibitor adenosine 5"-(alpha,beta-methylene) diphosphate (APCP) or by gene-targeted deletion of cd73.	alpha,beta-methyleneadenosine 5'-diphosphate	245-292	5' nucleotidase, ecto	Mus musculus	12-31
17855480-4	2007	Because the ecto-5-nucleotidase (CD73, conversion of AMP to adenosine) is considered the pacemaker of extracellular adenosine generation, we first tested the effect of blocking extracellular adenosine generation with the specific CD73-inhibitor adenosine 5"-(alpha,beta-methylene) diphosphate (APCP) or by gene-targeted deletion of cd73.	alpha,beta-methyleneadenosine 5'-diphosphate	245-292	5' nucleotidase, ecto	Mus musculus	33-37
17643826-8	2007	In addition, the cell treatment with APCP (alpha,beta-methyleneadenosine-5"-diphosphate), an ecto-5"-NT/CD73 inhibitor, led to a significant reduction in glioma cell proliferation.	alpha,beta-methyleneadenosine 5'-diphosphate	43-87	5'-nucleotidase ecto	Homo sapiens	104-108
17487388-3	2007	In this study, alpha,beta-methylene adenosine-5"-diphosphate (APCP), a specific CD73 inhibitor was used to block the hydrolase"s activity.	alpha,beta-methyleneadenosine 5'-diphosphate	15-60	5'-nucleotidase ecto	Homo sapiens	80-84
19966059-6	2010	The upregulation of adenosine receptors by phenylephrine was also abrogated by adenosine 5"-(alpha,beta-methylene)diphosphate, an inhibitor of ectosolic 5"-nucleotidase.	alpha,beta-methyleneadenosine 5'-diphosphate	79-125	5' nucleotidase, ecto	Rattus norvegicus	153-168
18223197-4	2008	In 17 control kidneys pretreated with alpha,beta-methylene-adenosine-5"-diphosphate (inhibitor of ecto-5"-nucleotidase to prevent AMP metabolism; 100 microM), addition of cAMP (10 microM) to the perfusate increased renal venous AMP from 0.6 +/- 0.2 to 3.5 +/- 0.5 nmol/min/g.	alpha,beta-methyleneadenosine 5'-diphosphate	38-83	5' nucleotidase, ecto	Rattus norvegicus	98-118
18404437-7	2007	Ecto-5"-nucleotidase was susceptible to inhibition by zinc acetate and by alpha,beta-methylene-adenosine diphosphate (alpha,beta-methylene-ADP).	alpha,beta-methyleneadenosine 5'-diphosphate	118-142	5'-nucleotidase ecto	Homo sapiens	0-20
18404437-10	2007	Ecto-5"-nucleotidase appears to be the major enzyme responsible for generation of adenosine from adenine nucleotides in the T84 cell line, and inhibitors of ecto-5"-nucleotidase, such as alpha,beta-methylene-ADP and zinc, might be useful for treatment of the watery diarrhea produced by EPEC infection.	alpha,beta-methyleneadenosine 5'-diphosphate	187-211	5'-nucleotidase ecto	Homo sapiens	157-177
15465666-7	2004	However, a significant inhibition of AMP hydrolysis (42%) was observed in the presence of 100 microM alpha,beta-methylene-ADP, a known inhibitor of ecto-5"-nucleotidase.	alpha,beta-methyleneadenosine 5'-diphosphate	101-125	5'-nucleotidase, ecto (CD73)	Danio rerio	153-168
16029911-10	2005	Since extracellular ATP is rapidly metabolized to adenosine, we also assessed ATP outflow in the presence of the ecto-5"-nucleotidase inhibitor, alpha,beta-methylene-adenosine diphosphate (AOPCP, 1 mM) directly perfused into the striatum.	alpha,beta-methyleneadenosine 5'-diphosphate	189-194	5' nucleotidase, ecto	Rattus norvegicus	113-133
15893296-7	2005	Inhibition of the enzymatic conversion of ATP to adenosine using a combination of a potent ecto-5"-nucleotidase inhibitor, alpha,beta-methylene adenosine 5"-diphosphate (AMP-CP), and a competitive substrate for ecto-5"-nucleotidase (guanosine monophosphate, GMP) did not affect basal VP release.	alpha,beta-methyleneadenosine 5'-diphosphate	170-176	5'-nucleotidase ecto	Homo sapiens	211-231
15893296-7	2005	Inhibition of the enzymatic conversion of ATP to adenosine using a combination of a potent ecto-5"-nucleotidase inhibitor, alpha,beta-methylene adenosine 5"-diphosphate (AMP-CP), and a competitive substrate for ecto-5"-nucleotidase (guanosine monophosphate, GMP) did not affect basal VP release.	alpha,beta-methyleneadenosine 5'-diphosphate	170-176	arginine vasopressin	Homo sapiens	284-286
15451788-8	2004	The magnitude of the infarct-limiting effect paralleled the increase in Akt and ecto-5"-nucleotidase activity and was blunted by administration of wortmannin, alpha,beta-methyleneadenosine-5"-diphosphate, or 8-sulfophenyltheophylline during reperfusion.	alpha,beta-methyleneadenosine 5'-diphosphate	159-203	5'-nucleotidase ecto	Canis lupus familiaris	85-100
15458441-11	2004	When hydrolysis of adenosine monophosphate (AMP) to adenosine was blocked by supplementing the bath with 100 micromol/L alpha,beta-methylene adenosine 5"-diphosphate (MADP), an inhibitor of 5"-nucleotidase, tubuloglomerular feedback response was blocked and diameter remained unchanged.	alpha,beta-methyleneadenosine 5'-diphosphate	120-165	LOW QUALITY PROTEIN: 5'-nucleotidase	Oryctolagus cuniculus	190-205
15458441-11	2004	When hydrolysis of adenosine monophosphate (AMP) to adenosine was blocked by supplementing the bath with 100 micromol/L alpha,beta-methylene adenosine 5"-diphosphate (MADP), an inhibitor of 5"-nucleotidase, tubuloglomerular feedback response was blocked and diameter remained unchanged.	alpha,beta-methyleneadenosine 5'-diphosphate	167-171	LOW QUALITY PROTEIN: 5'-nucleotidase	Oryctolagus cuniculus	190-205
12356888-3	2002	This inosine signal was greatly reduced by addition of the ecto-5"-nucleotidase inhibitor alpha,beta-methylene ADP (200 microM), suggesting that the inosine arose from adenosine that was produced in the extracellular space by the prior release of ATP.	alpha,beta-methyleneadenosine 5'-diphosphate	90-114	5' nucleotidase, ecto	Rattus norvegicus	59-79
15044076-8	2004	Intracerebroventricular treatment with 960 nmol GMP prevented 80% of seizures and the 5"-nucleotidase inhibitor alpha-beta-methyleneadenosine 5"-diphosphate (AOPCP), when injected 3 min before, reduced this anticonvulsant effect to 30% protection as well as significantly decreased the conversion of GMP into guanosine measured in the CSF.	alpha,beta-methyleneadenosine 5'-diphosphate	112-156	5'-nucleotidase ecto	Homo sapiens	86-101
15044076-8	2004	Intracerebroventricular treatment with 960 nmol GMP prevented 80% of seizures and the 5"-nucleotidase inhibitor alpha-beta-methyleneadenosine 5"-diphosphate (AOPCP), when injected 3 min before, reduced this anticonvulsant effect to 30% protection as well as significantly decreased the conversion of GMP into guanosine measured in the CSF.	alpha,beta-methyleneadenosine 5'-diphosphate	158-163	5'-nucleotidase ecto	Homo sapiens	86-101
14578500-7	2003	The 5"-AMP-induced increase in intracellular cAMP level was inhibited markedly by xanthine amine congener, an adenosine receptor antagonist, and partially by alpha,beta-methylene adenosine 5"-diphosphate, an ecto-5"-nucleotidase inhibitor.	alpha,beta-methyleneadenosine 5'-diphosphate	158-203	5'-nucleotidase ecto	Homo sapiens	208-228
12670309-6	2003	The source for extracellular adenosine was likely to be intracellular adenosine as the ecto-5"-nucleotidase inhibitor alpha beta-methylene-ADP was unable to block the effect of NMDA.	alpha,beta-methyleneadenosine 5'-diphosphate	118-142	5' nucleotidase, ecto	Rattus norvegicus	87-107
12370277-9	2002	In vivo studies in a murine hypoxia model revealed that hypoxia-induced CD73 may serve to protect the epithelial barrier, since the CD73 inhibitor alpha,beta-methylene ADP promotes increased intestinal permeability.	alpha,beta-methyleneadenosine 5'-diphosphate	147-171	5' nucleotidase, ecto	Mus musculus	72-76
12370277-9	2002	In vivo studies in a murine hypoxia model revealed that hypoxia-induced CD73 may serve to protect the epithelial barrier, since the CD73 inhibitor alpha,beta-methylene ADP promotes increased intestinal permeability.	alpha,beta-methyleneadenosine 5'-diphosphate	147-171	5' nucleotidase, ecto	Mus musculus	132-136
14993098-11	2004	Although inhibition of ecto-5"-nucleotidase by alpha,beta-methylene ADP (200 microm) or by concanavalin A (0.1 mg ml(-1)) attenuated endogenous adenosine formation from AMP, analysed by HPLC, the corresponding reduction in [(3)H]ACh release only became evident when stimulation of the myenteric plexus was prolonged to over 250 s. 5.	alpha,beta-methyleneadenosine 5'-diphosphate	47-71	5' nucleotidase, ecto	Rattus norvegicus	23-43
14687222-5	2004	A specific inhibitor of 5"-NT, adenosine 5"-[alpha,beta-methylene] diphosphate blocked the inhibition of GM-CSF production, suggesting that adenosine converted from 5"-AMP acts on the inhibitory effects.	alpha,beta-methyleneadenosine 5'-diphosphate	31-78	colony stimulating factor 2	Homo sapiens	105-111
12356889-6	2002	Addition of the ecto-5"-nucleotidase inhibitor alpha,beta-methylene ADP (200 microM) to the dorsal surface of the brainstem completely abolished the signal evoked by hypoxia, suggesting that the inosine arose from adenosine that was produced in the extracellular space by the prior release of ATP.	alpha,beta-methyleneadenosine 5'-diphosphate	47-71	5' nucleotidase, ecto	Rattus norvegicus	16-36
10978314-5	2000	The ecto-5"-nucleotidase inhibitor, alpha,beta-methylene ADP (100 microm), caused a larger inhibition (54%) of adenosine release in the presence of AA (30 microm) compared with control (37% inhibition) indicating that the AA-induced extracellular adenosine accumulation is mostly originated from an increased release and extracellular catabolism of ATP.	alpha,beta-methyleneadenosine 5'-diphosphate	36-60	5' nucleotidase, ecto	Rattus norvegicus	4-24
11509639-8	2001	Because ecto 5" nucleotidase inhibitor (alpha,beta-methylene adenosine-5"-diphosphate) blocked the effect of MTX, adenosine mimicked the effect of MTX, and adenosine A2b receptor antagonist (3,7-dimethyl-1-propargylxanthine) reversed the inhibitory effect of MTX, we suggest that MTX suppresses NF-kappaB activation by releasing adenosine.	alpha,beta-methyleneadenosine 5'-diphosphate	40-85	5'-nucleotidase ecto	Homo sapiens	8-28
11145997-4	2001	This conversion is decreased by the ecto-5"-nucleotidase inhibitor, alpha,beta-methylene ADP.	alpha,beta-methyleneadenosine 5'-diphosphate	68-92	5' nucleotidase, ecto	Rattus norvegicus	36-56
11173996-7	2001	The adenosine production was blocked by the 5"-nucleotidase inhibitor, alpha,beta-methylene adenosine 5"-diphosphate (MADP, 1 mmol/l), which was accompanied by a corresponding accumulation of 5"-AMP.	alpha,beta-methyleneadenosine 5'-diphosphate	71-116	5'-nucleotidase	Bos taurus	44-59
11173996-7	2001	The adenosine production was blocked by the 5"-nucleotidase inhibitor, alpha,beta-methylene adenosine 5"-diphosphate (MADP, 1 mmol/l), which was accompanied by a corresponding accumulation of 5"-AMP.	alpha,beta-methyleneadenosine 5'-diphosphate	118-122	5'-nucleotidase	Bos taurus	44-59
10543721-6	1999	In the presence of AOPCP (alpha,beta-methyleneadenosine 5"-diphosphate), an ecto-5"-nucleotidase inhibitor, the ganglion-stimulated increase in interstitial ATP and adenosine reached levels similar to those in the absence of AOPCP, also suggesting that adenosine does not derive from extracellular ATP.	alpha,beta-methyleneadenosine 5'-diphosphate	19-24	5' nucleotidase, ecto	Rattus norvegicus	76-96
11014304-3	2000	Kd values (+/- Ca2+) for the complexes of apyrase with the non-hydrolysable phosphonate adenine nucleotide analogues, adenosine 5"-(beta,gamma-methylene) triphosphate and adenosine 5"-(alpha,beta-methylene) diphosphate, were obtained from quenching of the intrinsic enzyme fluorescence.	alpha,beta-methyleneadenosine 5'-diphosphate	171-218	apyrase	Solanum tuberosum	42-49
10869532-10	2000	Administration of alpha,beta-methylene adenosine diphosphate (AMP-CP), an inhibitor of ecto-5"-nucleotidase, significantly diminished the tolerance to ischemia-reperfusion injury in H group (P<0.05).	alpha,beta-methyleneadenosine 5'-diphosphate	18-60	5' nucleotidase, ecto	Rattus norvegicus	87-107
10869532-10	2000	Administration of alpha,beta-methylene adenosine diphosphate (AMP-CP), an inhibitor of ecto-5"-nucleotidase, significantly diminished the tolerance to ischemia-reperfusion injury in H group (P<0.05).	alpha,beta-methyleneadenosine 5'-diphosphate	62-68	5' nucleotidase, ecto	Rattus norvegicus	87-107
10700389-5	2000	The introduction of AMP (100 microM) through the probe increased markedly the dialysate adenosine to 8.95 +/- 0.86 microM, and this increase was inhibited by ecto-5"-nucleotidase inhibitor, alpha, beta-methyleneadenosine 5"-diphosphate (AOPCP, 100 microM), to 0.66 +/- 0.38 microM.	alpha,beta-methyleneadenosine 5'-diphosphate	237-242	5' nucleotidase, ecto	Rattus norvegicus	158-178
10490889-5	1999	Further studies in rat cardiac fibroblasts revealed that the effects of A(1) receptor blockade on extracellular adenosine levels were concentration dependent and prevented by inhibition of G(i) proteins with pertussis toxin or blockade of ecto-5"-nucleotidase with alpha, beta-methyleneadenosine-5"-diphosphate.	alpha,beta-methyleneadenosine 5'-diphosphate	265-310	5' nucleotidase, ecto	Rattus norvegicus	239-259
10543721-6	1999	In the presence of AOPCP (alpha,beta-methyleneadenosine 5"-diphosphate), an ecto-5"-nucleotidase inhibitor, the ganglion-stimulated increase in interstitial ATP and adenosine reached levels similar to those in the absence of AOPCP, also suggesting that adenosine does not derive from extracellular ATP.	alpha,beta-methyleneadenosine 5'-diphosphate	26-70	5' nucleotidase, ecto	Rattus norvegicus	76-96
9580599-6	1998	Inhibition of 5"-nucleotidase by alpha, beta-methylene ADP dose-dependently decreased adenosine levels under basal as well as NMDA-stimulated conditions.	alpha,beta-methyleneadenosine 5'-diphosphate	33-58	5' nucleotidase, ecto	Rattus norvegicus	14-29
10422637-7	1999	Alpha,beta-methyleneadenosine 5"-diphosphate (alpha,beta-meADP, 100 microM), an inhibitor of ecto-5"-nucleotidase, abolished the AMP-induced increase in dialysate adenosine.	alpha,beta-methyleneadenosine 5'-diphosphate	0-44	5' nucleotidase, ecto	Rattus norvegicus	93-113
10206984-2	1999	The efflux elicited by a hypotonic shock was partially inhibited by adenosine receptor antagonists, by alpha,beta-methyleneadenosine 5"-diphosphate (alphabetaMeADP), an inhibitor of the 5"-ectonucleotidase, and by adenosine deaminase.	alpha,beta-methyleneadenosine 5'-diphosphate	103-147	adenosine deaminase	Homo sapiens	214-233
9315551-4	1997	The intracoronary administration of alpha,beta-methyleneadenosine 5"-diphosphate, an inhibitor of ecto-5"-nucleotidase, or GF109203X or calphostin C, both of which are PKC inhibitors, attenuated the L-NAME-induced increases in adenosine levels and ecto-5"-nucleotidase activity.	alpha,beta-methyleneadenosine 5'-diphosphate	36-80	5'-nucleotidase ecto	Homo sapiens	98-118
9435300-3	1998	First, pretreatment of a human microvascular endothelial cell line (HMEC-1) with methotrexate increases extracellular adenosine after exposure of the pretreated cells to activated neutrophils; the ecto-5"-nucleotidase inhibitor alpha, beta-methylene adenosine-5"-diphosphate (APCP) abrogates completely the increase in extracellular adenosine.	alpha,beta-methyleneadenosine 5'-diphosphate	228-274	5'-nucleotidase ecto	Homo sapiens	197-217
9581572-5	1997	5"-Nucleotidase activity was inhibited by adenosine 5"-[alpha,beta-methylene]diphosphate and concanavalin A, followed simple Michaelis-Menten kinetics and was released from the membranes by treatment with phosphatidylinositol-specific phospholipase C, indicating that AMP hydrolysis in T-tubules is catalysed by a typical ecto-5"-nucleotidase.	alpha,beta-methyleneadenosine 5'-diphosphate	42-88	5'-nucleotidase ecto	Gallus gallus	0-15
9581572-5	1997	5"-Nucleotidase activity was inhibited by adenosine 5"-[alpha,beta-methylene]diphosphate and concanavalin A, followed simple Michaelis-Menten kinetics and was released from the membranes by treatment with phosphatidylinositol-specific phospholipase C, indicating that AMP hydrolysis in T-tubules is catalysed by a typical ecto-5"-nucleotidase.	alpha,beta-methyleneadenosine 5'-diphosphate	42-88	5'-nucleotidase ecto	Gallus gallus	327-342
9436817-3	1997	With an inhibitor of 5"-nucleotidase, alpha,beta-methylene adenosine 5"-diphosphate (AMP-CP), ecto-5"-nucleotidase activity in the ischemic region was comparable to that in the nonischemic region.	alpha,beta-methyleneadenosine 5'-diphosphate	38-83	LOW QUALITY PROTEIN: 5'-nucleotidase	Oryctolagus cuniculus	99-114
9436817-3	1997	With an inhibitor of 5"-nucleotidase, alpha,beta-methylene adenosine 5"-diphosphate (AMP-CP), ecto-5"-nucleotidase activity in the ischemic region was comparable to that in the nonischemic region.	alpha,beta-methyleneadenosine 5'-diphosphate	85-91	LOW QUALITY PROTEIN: 5'-nucleotidase	Oryctolagus cuniculus	21-36
9436817-3	1997	With an inhibitor of 5"-nucleotidase, alpha,beta-methylene adenosine 5"-diphosphate (AMP-CP), ecto-5"-nucleotidase activity in the ischemic region was comparable to that in the nonischemic region.	alpha,beta-methyleneadenosine 5'-diphosphate	85-91	LOW QUALITY PROTEIN: 5'-nucleotidase	Oryctolagus cuniculus	99-114
9315551-4	1997	The intracoronary administration of alpha,beta-methyleneadenosine 5"-diphosphate, an inhibitor of ecto-5"-nucleotidase, or GF109203X or calphostin C, both of which are PKC inhibitors, attenuated the L-NAME-induced increases in adenosine levels and ecto-5"-nucleotidase activity.	alpha,beta-methyleneadenosine 5'-diphosphate	36-80	5'-nucleotidase ecto	Homo sapiens	248-268
9169488-10	1997	An inhibitor of the ecto-5"-nucleotidase CD73, alpha, beta-methylene ADP (AOPCP), inhibited epithelial Cl- secretory responses to 5"-AMP, but not to authentic adenosine.	alpha,beta-methyleneadenosine 5'-diphosphate	47-72	5'-nucleotidase ecto	Homo sapiens	20-40
9288680-6	1997	alpha, beta-Methyleneadenosine 5"-diphosphate (AOPCP, 100 microM), an inhibitor of ecto-5"-nucleotidase, abolished the AMP-induced increase in dialysate adenosine, but did not affect the baseline level of adenosine.	alpha,beta-methyleneadenosine 5'-diphosphate	0-45	5' nucleotidase, ecto	Rattus norvegicus	83-103
9288680-6	1997	alpha, beta-Methyleneadenosine 5"-diphosphate (AOPCP, 100 microM), an inhibitor of ecto-5"-nucleotidase, abolished the AMP-induced increase in dialysate adenosine, but did not affect the baseline level of adenosine.	alpha,beta-methyleneadenosine 5'-diphosphate	47-52	5' nucleotidase, ecto	Rattus norvegicus	83-103
9336768-6	1997	In contrast, the coapplication of a cAMP-phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine (IBMX), or a 5"-nucleotidase inhibitor, adenosine 5"-[alpha, beta-methylene] diphosphate (AMP-CP), enhanced the cAMP-induced suppressive effect.	alpha,beta-methyleneadenosine 5'-diphosphate	138-186	5' nucleotidase, ecto	Rattus norvegicus	111-126
9169488-10	1997	An inhibitor of the ecto-5"-nucleotidase CD73, alpha, beta-methylene ADP (AOPCP), inhibited epithelial Cl- secretory responses to 5"-AMP, but not to authentic adenosine.	alpha,beta-methyleneadenosine 5'-diphosphate	47-72	5'-nucleotidase ecto	Homo sapiens	41-45
9169488-10	1997	An inhibitor of the ecto-5"-nucleotidase CD73, alpha, beta-methylene ADP (AOPCP), inhibited epithelial Cl- secretory responses to 5"-AMP, but not to authentic adenosine.	alpha,beta-methyleneadenosine 5'-diphosphate	74-79	5'-nucleotidase ecto	Homo sapiens	20-40
9169488-10	1997	An inhibitor of the ecto-5"-nucleotidase CD73, alpha, beta-methylene ADP (AOPCP), inhibited epithelial Cl- secretory responses to 5"-AMP, but not to authentic adenosine.	alpha,beta-methyleneadenosine 5'-diphosphate	74-79	5'-nucleotidase ecto	Homo sapiens	41-45
8945621-6	1996	The presence of exogenous adenosine (0.5 microM) circumvented AMP-CP-induced inhibition of rhodamine efflux from EL4/ADM cells.	alpha,beta-methyleneadenosine 5'-diphosphate	62-68	epilepsy 4	Mus musculus	113-116
8928882-7	1996	The infarct size-limiting effect due to cromakalim and nicorandil was blunted by alpha,beta-methyleneadenosine 5"-diphosphate, an inhibitor of ectosolic 5"-nucleotidase [infarct size, 37.7 +/- 5.6 (n = 9) and 36.8 +/- 4.8% (n = 7), respectively] and 8-sulfophenyltheophylline (infarct size with cromakalim, 44.7 +/- 4.6%; n = 7).	alpha,beta-methyleneadenosine 5'-diphosphate	81-125	5'-nucleotidase ecto	Canis lupus familiaris	153-168
8901821-5	1996	The conversion of cAMP to adenosine and inosine was inhibited by blockade of phosphodiesterase with IBMX, of ecto-phosphodiesterase with DPSPX, and of ecto-5"-nucleotidase with AMP-CP.	alpha,beta-methyleneadenosine 5'-diphosphate	177-183	5'-nucleotidase ecto	Homo sapiens	151-171
8645720-9	1996	50 microM, alpha,beta-methylene adenosine 5"-diphosphate (AOPCP), a selective inhibitor of ecto 5"-nucleotidase, elevated interstitial AMP concentration tenfold, did not attenuate basal nucleoside release, but completely inhibited Mg2+-stimulated coronary venous purine nucleoside release and blunted Mg2+-stimulated interstitial purine nucleoside formation by 69%.	alpha,beta-methyleneadenosine 5'-diphosphate	11-56	5'-nucleotidase ecto	Homo sapiens	91-111
8645720-9	1996	50 microM, alpha,beta-methylene adenosine 5"-diphosphate (AOPCP), a selective inhibitor of ecto 5"-nucleotidase, elevated interstitial AMP concentration tenfold, did not attenuate basal nucleoside release, but completely inhibited Mg2+-stimulated coronary venous purine nucleoside release and blunted Mg2+-stimulated interstitial purine nucleoside formation by 69%.	alpha,beta-methyleneadenosine 5'-diphosphate	11-56	mucin 7, secreted	Homo sapiens	231-234
8645720-9	1996	50 microM, alpha,beta-methylene adenosine 5"-diphosphate (AOPCP), a selective inhibitor of ecto 5"-nucleotidase, elevated interstitial AMP concentration tenfold, did not attenuate basal nucleoside release, but completely inhibited Mg2+-stimulated coronary venous purine nucleoside release and blunted Mg2+-stimulated interstitial purine nucleoside formation by 69%.	alpha,beta-methyleneadenosine 5'-diphosphate	11-56	mucin 7, secreted	Homo sapiens	301-304
8645720-9	1996	50 microM, alpha,beta-methylene adenosine 5"-diphosphate (AOPCP), a selective inhibitor of ecto 5"-nucleotidase, elevated interstitial AMP concentration tenfold, did not attenuate basal nucleoside release, but completely inhibited Mg2+-stimulated coronary venous purine nucleoside release and blunted Mg2+-stimulated interstitial purine nucleoside formation by 69%.	alpha,beta-methyleneadenosine 5'-diphosphate	58-63	5'-nucleotidase ecto	Homo sapiens	91-111
8645720-9	1996	50 microM, alpha,beta-methylene adenosine 5"-diphosphate (AOPCP), a selective inhibitor of ecto 5"-nucleotidase, elevated interstitial AMP concentration tenfold, did not attenuate basal nucleoside release, but completely inhibited Mg2+-stimulated coronary venous purine nucleoside release and blunted Mg2+-stimulated interstitial purine nucleoside formation by 69%.	alpha,beta-methyleneadenosine 5'-diphosphate	58-63	mucin 7, secreted	Homo sapiens	231-234
8645720-9	1996	50 microM, alpha,beta-methylene adenosine 5"-diphosphate (AOPCP), a selective inhibitor of ecto 5"-nucleotidase, elevated interstitial AMP concentration tenfold, did not attenuate basal nucleoside release, but completely inhibited Mg2+-stimulated coronary venous purine nucleoside release and blunted Mg2+-stimulated interstitial purine nucleoside formation by 69%.	alpha,beta-methyleneadenosine 5'-diphosphate	58-63	mucin 7, secreted	Homo sapiens	301-304
8182151-8	1994	Intermittent alpha 1-adrenoceptor stimulation by methoxamine mimicked the increase in 5"-nucleotidase activity and the infarct size-limiting effect, which were abolished by alpha, beta,-methyleneadenosine 5"-diphosphate.	alpha,beta-methyleneadenosine 5'-diphosphate	173-219	5'-nucleotidase ecto	Canis lupus familiaris	86-101
7697853-8	1995	The increase in adenosine release was blunted by GF109203X and alpha, beta-methyleneadenosine 5"-diphosphate, an inhibitor of ecto-5"-nucleotidase.	alpha,beta-methyleneadenosine 5'-diphosphate	63-108	5' nucleotidase, ecto	Rattus norvegicus	126-146
8053684-1	1994	When alpha,beta-methylene ADP (alpha,beta-CH2-ADP) is added to the phosphorylated calcium ATPase of sarcoplasmic reticulum with Ca(2+)-bound, Ca2.E approximately P.Mg, alpha,beta-methylene ATP is not synthesized (5 mM MgCl2, 100 mM KCl, pH 7.0, 25 degrees C).	alpha,beta-methyleneadenosine 5'-diphosphate	5-29	WD and tetratricopeptide repeats 1	Homo sapiens	31-49
8779965-6	1996	Addition of alpha, beta-methyleneadenosine 5"-diphosphate (50 microM) to inhibit 5"-nucleotidase activity increased AMP concentrations two- to threefold.	alpha,beta-methyleneadenosine 5'-diphosphate	12-57	5'-nucleotidase ecto	Homo sapiens	81-96
7532359-5	1995	An inhibitor of 5"-nucleotidase, alpha,beta-methyleneadenosine 5"-diphosphate, blocked most of the response to luminal ATP.	alpha,beta-methyleneadenosine 5'-diphosphate	33-77	5'-nucleotidase ecto	Homo sapiens	16-31
7927909-9	1994	An inhibitor of ecto-5"NT, alpha,beta-methyleneadenosine 5"-diphosphate, completely reversed the resistance of the EL4/ADM cell line to doxorubicin.	alpha,beta-methyleneadenosine 5'-diphosphate	27-71	epilepsy 4	Mus musculus	115-118
8152230-11	1994	The addition of the 5"-nucleotidase inhibitor, AMPCP, to cold crystalloid cardioplegia enhances postischemic myocardial performance in vivo and may be useful during prolonged periods of global myocardial ischemia.	alpha,beta-methyleneadenosine 5'-diphosphate	47-52	5'-nucleotidase ecto	Canis lupus familiaris	20-35
8130931-7	1994	In the hippocampus, alpha,beta-methylene ADP (100 microM) increased the evoked release of tritium, and adenosine deaminase (2 U/ml) produced an even greater increase; when adenosine deaminase was added in the presence of alpha,beta-methylene ADP, adenosine deaminase still increased the evoked release of tritium.	alpha,beta-methyleneadenosine 5'-diphosphate	20-44	adenosine deaminase	Rattus norvegicus	172-191
8130931-7	1994	In the hippocampus, alpha,beta-methylene ADP (100 microM) increased the evoked release of tritium, and adenosine deaminase (2 U/ml) produced an even greater increase; when adenosine deaminase was added in the presence of alpha,beta-methylene ADP, adenosine deaminase still increased the evoked release of tritium.	alpha,beta-methyleneadenosine 5'-diphosphate	20-44	adenosine deaminase	Rattus norvegicus	172-191
8130931-7	1994	In the hippocampus, alpha,beta-methylene ADP (100 microM) increased the evoked release of tritium, and adenosine deaminase (2 U/ml) produced an even greater increase; when adenosine deaminase was added in the presence of alpha,beta-methylene ADP, adenosine deaminase still increased the evoked release of tritium.	alpha,beta-methyleneadenosine 5'-diphosphate	221-245	adenosine deaminase	Rattus norvegicus	103-122
8130931-7	1994	In the hippocampus, alpha,beta-methylene ADP (100 microM) increased the evoked release of tritium, and adenosine deaminase (2 U/ml) produced an even greater increase; when adenosine deaminase was added in the presence of alpha,beta-methylene ADP, adenosine deaminase still increased the evoked release of tritium.	alpha,beta-methyleneadenosine 5'-diphosphate	221-245	adenosine deaminase	Rattus norvegicus	172-191
8130931-7	1994	In the hippocampus, alpha,beta-methylene ADP (100 microM) increased the evoked release of tritium, and adenosine deaminase (2 U/ml) produced an even greater increase; when adenosine deaminase was added in the presence of alpha,beta-methylene ADP, adenosine deaminase still increased the evoked release of tritium.	alpha,beta-methyleneadenosine 5'-diphosphate	221-245	adenosine deaminase	Rattus norvegicus	172-191
8417143-3	1993	The ecto-5"-nucleotidase (EC 3.1.3.5) had a Km of 21 microM, was inhibited by AMPPNP and alpha,beta-methylene ADP, and by a specific antiserum.	alpha,beta-methyleneadenosine 5'-diphosphate	89-113	5'-nucleotidase ecto	Homo sapiens	4-24
8515275-10	1993	Inhibition of ecto-5"-nucleotidase by alpha,beta-methylene ADP and GMP did not affect basal adenosine outflow but potentiated "ischemia"-evoked adenosine outflow.	alpha,beta-methyleneadenosine 5'-diphosphate	38-62	5' nucleotidase, ecto	Rattus norvegicus	14-34
8450475-9	1993	Moreover, reduction of extracellular adenosine formation by a focal injection of an ecto-5"-nucleotidase inhibitor, alpha, beta-methyleneadenosine diphosphate, produced generalized seizures (ED50 = 37.3 +/- 22.7 nmol).	alpha,beta-methyleneadenosine 5'-diphosphate	116-158	5' nucleotidase, ecto	Rattus norvegicus	84-104
8417143-6	1993	The intraterminal 5"-nucleotidase enzyme, which amounted to 40% of the total 5"-nucleotidase activity, was inhibited by AMPPNP, alpha,beta-methylene ADP, and the antiserum, and also had the same kinetic properties as the ectoenzyme.	alpha,beta-methyleneadenosine 5'-diphosphate	128-152	5'-nucleotidase ecto	Homo sapiens	18-33
8417143-6	1993	The intraterminal 5"-nucleotidase enzyme, which amounted to 40% of the total 5"-nucleotidase activity, was inhibited by AMPPNP, alpha,beta-methylene ADP, and the antiserum, and also had the same kinetic properties as the ectoenzyme.	alpha,beta-methyleneadenosine 5'-diphosphate	128-152	5'-nucleotidase ecto	Homo sapiens	77-92
8456972-8	1993	Inhibition of ecto-5"-nucleotidase by alpha,beta-methylene-ADP (5 x 10(-5) M) enhanced AN release from 2.6 to 8.2 pmol.min-1 x ml CV-1 and reduced ADO release by an equivalent extent.	alpha,beta-methyleneadenosine 5'-diphosphate	38-62	5'-nucleotidase ecto	Homo sapiens	14-34
1499105-7	1992	When an inhibitor of ecto-5"-nucleotidase, alpha, beta-methyleneadenosine 5"-diphosphate, was administered, the effects of superoxide dismutase were completely abolished.	alpha,beta-methyleneadenosine 5'-diphosphate	43-88	5'-nucleotidase ecto	Canis lupus familiaris	26-41
1832463-7	1991	In the presence of BWA1433U and a continuous intralobar infusion of the selective 5"-nucleotidase inhibitor, alpha,beta-methyleneadenosine-5"-diphosphate, ATP VC responses are significantly enhanced compared to those after BWA1433U.	alpha,beta-methyleneadenosine 5'-diphosphate	109-153	5'-nucleotidase ecto	Homo sapiens	82-97
2352651-9	1990	Decreasing the levels of endogenous adenosine by increasing the concentration of adenosine deaminase and adding the 5"-nucleotidase inhibitor alpha-beta-methylene adenosine-5"-diphosphate gave an increase in [3H]8-cyclopentyl-1,3-dipropylxanthine binding and diminished the response to GTP.	alpha,beta-methyleneadenosine 5'-diphosphate	142-187	5' nucleotidase, ecto	Rattus norvegicus	116-131
1998727-6	1991	Adenosine 5"-[alpha,beta-methylene]diphosphate is a competitive inhibitor of 5"-nucleotidase, whereas concanavalin A inhibits the enzymatic activity in a non-competitive manner.	alpha,beta-methyleneadenosine 5'-diphosphate	0-46	5'-nucleotidase ecto	Homo sapiens	77-92
12106218-5	1991	Inhibition of ecto-5"-nucleotidase by alpha,beta-methylene ADP and GMP decreased basal and stimulated efflux of adenosine in the cerebellum by 50 - 60%, indicating that a significant proportion of adenosine was derived from the extracellular metabolism of released nucleotides.	alpha,beta-methyleneadenosine 5'-diphosphate	38-62	5' nucleotidase, ecto	Rattus norvegicus	14-34
1898656-8	1991	alpha, beta-Methyleneadenosine 5"-diphosphate (AMPCP, 2.5 mM), an inhibitor of membranous ecto-5"-nucleotidase, profoundly inhibited endogenous adenosine accumulation under all conditions.	alpha,beta-methyleneadenosine 5'-diphosphate	0-45	5'-nucleotidase ecto	Homo sapiens	90-110
1898656-8	1991	alpha, beta-Methyleneadenosine 5"-diphosphate (AMPCP, 2.5 mM), an inhibitor of membranous ecto-5"-nucleotidase, profoundly inhibited endogenous adenosine accumulation under all conditions.	alpha,beta-methyleneadenosine 5'-diphosphate	47-52	5'-nucleotidase ecto	Homo sapiens	90-110
1980648-5	1990	ATP was more effective than AMPPCP (the non-hydrolyzable analog of ATP), and ADP was more effective than ADP beta S and AMPCP (the hydrolysis-resistant analogs of ADP) to increase basal and ANF-stimulated guanylate cyclase activities.	alpha,beta-methyleneadenosine 5'-diphosphate	120-125	natriuretic peptide A	Rattus norvegicus	190-193
1967143-4	1990	Inhibition of ecto-5"-nucleotidase by alpha,beta-methylene ADP and GMP decreased basal release of adenosine by 40%, indicating that part of the adenosine was derived from the extracellular metabolism of released nucleotide.	alpha,beta-methyleneadenosine 5'-diphosphate	38-62	5' nucleotidase, ecto	Rattus norvegicus	14-34
2993513-5	1985	In the presence of alpha,beta-methylene ADP and GMP, which inhibit ecto-5"-nucleotidase, conversion of added ATP and AMP to adenosine was inhibited by 90% in synaptosomal suspensions.	alpha,beta-methyleneadenosine 5'-diphosphate	19-43	5' nucleotidase, ecto	Rattus norvegicus	67-87
2539728-4	1989	Inhibition of ecto-5"-nucleotidase with 100 microM alpha, beta-methyleneadenosine 5"-diphosphate (AOPCP) reduced plasma adenosine to 22 +/- 6 nM.	alpha,beta-methyleneadenosine 5'-diphosphate	98-103	5'-nucleotidase ecto	Homo sapiens	14-34
34650622-9	2021	Additional cellular studies demonstrated that blocking the expression and hydrolase activity of CD73 with alpha,beta-methylene ADP (APCP) could counteract the protective effect of CD73 on neuronal apoptosis, while adenosine (Ado) could rescue the increased apoptosis caused by CD73 deletion.	alpha,beta-methyleneadenosine 5'-diphosphate	106-130	5' nucleotidase, ecto	Mus musculus	96-100
34650622-9	2021	Additional cellular studies demonstrated that blocking the expression and hydrolase activity of CD73 with alpha,beta-methylene ADP (APCP) could counteract the protective effect of CD73 on neuronal apoptosis, while adenosine (Ado) could rescue the increased apoptosis caused by CD73 deletion.	alpha,beta-methyleneadenosine 5'-diphosphate	106-130	5' nucleotidase, ecto	Mus musculus	180-184
35416841-6	2022	Chronic constriction injury rat models were intraperitoneally injected with alpha,beta-methyleneadenosine 5"-diphosphate, an ecto-5"-nucleotidase inhibitor, 30 min before electroacupuncture.	alpha,beta-methyleneadenosine 5'-diphosphate	76-120	5' nucleotidase, ecto	Rattus norvegicus	125-145
34445661-5	2021	The CD73 inhibitor AMPCP significantly increased IL-6 and decreased IL-10 in both cell types, while TNF only increased in RA cells.	alpha,beta-methyleneadenosine 5'-diphosphate	19-24	5'-nucleotidase ecto	Homo sapiens	4-8
34445661-5	2021	The CD73 inhibitor AMPCP significantly increased IL-6 and decreased IL-10 in both cell types, while TNF only increased in RA cells.	alpha,beta-methyleneadenosine 5'-diphosphate	19-24	interleukin 6	Homo sapiens	49-53
34445661-5	2021	The CD73 inhibitor AMPCP significantly increased IL-6 and decreased IL-10 in both cell types, while TNF only increased in RA cells.	alpha,beta-methyleneadenosine 5'-diphosphate	19-24	interleukin 10	Homo sapiens	68-73
3593790-3	1987	The inhibitor of 5"-nucleotidase (alpha,beta-methylene)-ADP, did not affect PIMOI cleavage and moderately inhibited AMP hydrolysis (by ADP, did not affect PIMOI cleavage and moderately inhibited AMP hydrolysis (by 30-50%), thus suggesting that acidic phosphatases are responsible for PIMOI and AMP hydrolysis under these conditions (pH 6.3).	alpha,beta-methyleneadenosine 5'-diphosphate	34-59	5' nucleotidase, ecto	Rattus norvegicus	17-32
2537026-2	1989	Intramuscular injection of the ADP-analogue adenosine alpha, beta-methylene diphosphate (AMP-CP) achieved a 70% reduction in 5"-nucleotidase activity, as measured in crude extracts of rat kidney.	alpha,beta-methyleneadenosine 5'-diphosphate	44-87	5' nucleotidase, ecto	Rattus norvegicus	125-140
2537026-2	1989	Intramuscular injection of the ADP-analogue adenosine alpha, beta-methylene diphosphate (AMP-CP) achieved a 70% reduction in 5"-nucleotidase activity, as measured in crude extracts of rat kidney.	alpha,beta-methyleneadenosine 5'-diphosphate	89-95	5' nucleotidase, ecto	Rattus norvegicus	125-140
2854533-3	1988	Inhibition of 5"-nucleotidase activity with alpha, beta-methylene adenosine 5"-diphosphate (AMPCP), to reduce available endogenous adenosine, caused a dose-dependent inhibition of the fertilizing ability of partially capacitated spermatozoa, which was significant with 100 and 250 microM AMPCP.	alpha,beta-methyleneadenosine 5'-diphosphate	44-90	5' nucleotidase, ecto	Mus musculus	14-29
2854533-3	1988	Inhibition of 5"-nucleotidase activity with alpha, beta-methylene adenosine 5"-diphosphate (AMPCP), to reduce available endogenous adenosine, caused a dose-dependent inhibition of the fertilizing ability of partially capacitated spermatozoa, which was significant with 100 and 250 microM AMPCP.	alpha,beta-methyleneadenosine 5'-diphosphate	92-97	5' nucleotidase, ecto	Mus musculus	14-29
2854533-3	1988	Inhibition of 5"-nucleotidase activity with alpha, beta-methylene adenosine 5"-diphosphate (AMPCP), to reduce available endogenous adenosine, caused a dose-dependent inhibition of the fertilizing ability of partially capacitated spermatozoa, which was significant with 100 and 250 microM AMPCP.	alpha,beta-methyleneadenosine 5'-diphosphate	288-293	5' nucleotidase, ecto	Mus musculus	14-29
2840494-7	1988	Adenosine deaminase and 5"-nucleotidase exhibited similar kinetic parameters to enzymes from other sources and their activities were inhibited by coformycin and alpha, beta-methylene adenosine 5"-diphosphate, respectively.	alpha,beta-methyleneadenosine 5'-diphosphate	161-207	adenosine deaminase	Mus musculus	0-19
2840494-7	1988	Adenosine deaminase and 5"-nucleotidase exhibited similar kinetic parameters to enzymes from other sources and their activities were inhibited by coformycin and alpha, beta-methylene adenosine 5"-diphosphate, respectively.	alpha,beta-methyleneadenosine 5'-diphosphate	161-207	5' nucleotidase, ecto	Mus musculus	24-39
2954620-0	1987	[Potentiating synergism between alpha, beta-methylene ADP and acetylcholine on the secretion of insulin from the isolated pancreas of the newborn dog].	alpha,beta-methyleneadenosine 5'-diphosphate	32-57	insulin	Canis lupus familiaris	96-103
2954620-2	1987	alpha,beta-methylene ADP alone (16.5 microM) and acetylcholine alone (0.5 microM) induced a comparable increment of insulin secretion.	alpha,beta-methyleneadenosine 5'-diphosphate	0-24	insulin	Canis lupus familiaris	116-123
2954620-4	1987	Our results show a potentiating synergism between alpha,beta-methylene ADP and acetylcholine, on insulin secretion, alpha,beta-methylene ADP acting via a P2 purinoceptor and acetylcholine via a muscarinic receptor.	alpha,beta-methyleneadenosine 5'-diphosphate	50-74	insulin	Canis lupus familiaris	97-104
2984303-3	1985	The inhibition of lysosomal enzyme secretion by ATP, ADP, and AMP was reversed by adding alpha, beta -methylene ADP (100 microM), a 5"-nucleotidase inhibitor, to the incubation medium.	alpha,beta-methyleneadenosine 5'-diphosphate	89-115	5' nucleotidase, ecto	Mus musculus	132-147
3003346-3	1986	A competitive inhibitor of 5"-nucleotidase, alpha,beta-methyleneadenosine diphosphate (120 microM), inhibited the production of adenosine during hypoxia (perfusate, 0.26 +/- 0.05 microM and renal cortex, 3.1 nmol/g) but did not prevent the decline in cortical tissue ATP and ADP.	alpha,beta-methyleneadenosine 5'-diphosphate	44-85	5' nucleotidase, ecto	Rattus norvegicus	27-42
2983765-5	1985	The specific 5"-nucleotidase inhibitor, adenosine 5"-[alpha, beta-methylene] diphosphate also inhibited the canine enzyme in intact cells.	alpha,beta-methyleneadenosine 5'-diphosphate	40-88	5'-nucleotidase ecto	Canis lupus familiaris	13-28
6298508-4	1982	The activity of membrane-bound 5"-nucleotidase, that is, AMP-hydrolyzing activity inhibited by 100 microM alpha, beta-methyleneadenosine 5"-diphosphate, progressively increased as a function of age, indicating thymocyte population changes occurring very late in life.	alpha,beta-methyleneadenosine 5'-diphosphate	106-151	5' nucleotidase, ecto	Mus musculus	31-46
6098264-1	1984	Serum 5"-nucleotidase in rat and man is derived from the plasma membrane rather than the cytosol by the criteria of inhibition with [alpha beta-methylene]ADP and antisera.	alpha,beta-methyleneadenosine 5'-diphosphate	132-157	5' nucleotidase, ecto	Rattus norvegicus	6-21
6086190-3	1984	alpha-beta-Methylene adenosine diphosphate competitively inhibited 5" nucleotidase in lymphocytes from both healthy subjects and patients with CVH: the inhibitor constant (Ki) was higher for lymphocytes from patients with CVH than from control subjects.	alpha,beta-methyleneadenosine 5'-diphosphate	0-42	5'-nucleotidase ecto	Homo sapiens	67-82
6099286-2	1984	These activity differences were due to true 5"-nucleotidase as shown by its inactivation through specific inhibitors such as concanavalin A and alpha, beta-methylene adenosine diphosphate.	alpha,beta-methyleneadenosine 5'-diphosphate	144-187	5'-nucleotidase ecto	Homo sapiens	44-59
6303317-2	1983	This activity is inhibited by the alpha, beta-methyleneadenosine 5"-diphosphate, a specific inhibitor of 5"-nucleotidase.	alpha,beta-methyleneadenosine 5'-diphosphate	34-79	5' nucleotidase, ecto	Rattus norvegicus	105-120
6834814-2	1983	The breakdown of AMP to adenosine is catalyzed by 5"-nucleotidase and this enzyme was inhibited during the ischemic period with either concanavalin A (Con A, 3 mg/kg) or alpha, beta-methyleneadenosine 5"-diphosphate (AMP-CP, 250 microM).	alpha,beta-methyleneadenosine 5'-diphosphate	170-215	5'-nucleotidase ecto	Canis lupus familiaris	50-65
6834814-2	1983	The breakdown of AMP to adenosine is catalyzed by 5"-nucleotidase and this enzyme was inhibited during the ischemic period with either concanavalin A (Con A, 3 mg/kg) or alpha, beta-methyleneadenosine 5"-diphosphate (AMP-CP, 250 microM).	alpha,beta-methyleneadenosine 5'-diphosphate	217-223	5'-nucleotidase ecto	Canis lupus familiaris	50-65
6094404-4	1984	Kinetic values of 5"-nucleotidase for 5"-AMP (Km = 3-4 microM; Amax = 3-4 mumol/min) were substantially lower than those reported in vitro but also responded predictably to the competitive inhibitor of 5"-nucleotidase, adenosine 5"-[alpha, beta-methylene]diphosphate.	alpha,beta-methyleneadenosine 5'-diphosphate	219-266	5'-nucleotidase ecto	Homo sapiens	18-33
6291401-5	1982	Specific inhibition of plasma membrane 5"-nucleotidase with 50 microM alpha, beta-methylene adenosine diphosphate (AMPCP) did not decrease purine release during deoxyglucose-induced nucleotide degradation.	alpha,beta-methyleneadenosine 5'-diphosphate	115-120	5'-nucleotidase ecto	Homo sapiens	39-54
33399453-7	2021	Key binding interactions of the known inhibitor adenosine-5"-(alpha,beta-methylene)diphosphate (AMPCP) with hCD73 provided the foundation for our early designs.	alpha,beta-methyleneadenosine 5'-diphosphate	96-101	5'-nucleotidase ecto	Homo sapiens	108-113
6123548-3	1982	AMP was somewhat less effective than adenosine, and its effect could be partially, but not completely, abolished by alpha, beta-methylene-ADP and GMP, which inhibited its metabolism by 5"-nucleotidase.	alpha,beta-methyleneadenosine 5'-diphosphate	116-141	5' nucleotidase, ecto	Rattus norvegicus	185-200
7266930-1	1981	A marked depression of evoked CA1 potentials was observed with the nucleotide analogues a,b-methylene ADP (AOPCP) and adenylimido-diphosphate (AIP) and with 2"-adenosine monophosphate (2"-AMP).	alpha,beta-methyleneadenosine 5'-diphosphate	107-112	carbonic anhydrase 1	Rattus norvegicus	30-33
30781912-4	1979	Adenosine, AMP, 2- chloroadenosine, alpha,beta-methylene ADP and beta,gamma-methylene ATP each inhibited ATP-induced aggregation of platelets in rat PRP to a similar extent as ADP-induced aggregation.	alpha,beta-methyleneadenosine 5'-diphosphate	36-60	proline rich protein 2-like 1	Rattus norvegicus	149-152
33909515-6	2021	EXPERT OPINION: : Considerable advances have been reported in the design of nucleotide/nucleoside-based CD73 inhibitors, after the X-ray crystal structure of the enzyme in complex with the non-hydrolyzable ADP analog, adenosine (alpha,beta)-methylene diphosphate (AMPCP), was reported.	alpha,beta-methyleneadenosine 5'-diphosphate	264-269	5'-nucleotidase ecto	Homo sapiens	104-108
32313990-7	2020	By contrast, the ecto-phosphodiesterase inhibitor DPSPX (1,3-dipropyl-8-sulfophenylxanthine) and the CD73 ecto-5"-nucleotidase inhibitor AMP-CP (adenosine 5"-(alpha,beta-methylene)diphosphate) were not protective.	alpha,beta-methyleneadenosine 5'-diphosphate	137-143	5'-nucleotidase ecto	Homo sapiens	101-105
32865411-5	2020	Based on the binding mode of adenosine 5"-( , -methylene)diphosphate (AOPCP) with human CD73, we designed a series of novel monophosphonate small molecule CD73 inhibitors.	alpha,beta-methyleneadenosine 5'-diphosphate	70-75	5'-nucleotidase ecto	Homo sapiens	88-92
32865411-5	2020	Based on the binding mode of adenosine 5"-( , -methylene)diphosphate (AOPCP) with human CD73, we designed a series of novel monophosphonate small molecule CD73 inhibitors.	alpha,beta-methyleneadenosine 5'-diphosphate	70-75	5'-nucleotidase ecto	Homo sapiens	155-159
32313990-7	2020	By contrast, the ecto-phosphodiesterase inhibitor DPSPX (1,3-dipropyl-8-sulfophenylxanthine) and the CD73 ecto-5"-nucleotidase inhibitor AMP-CP (adenosine 5"-(alpha,beta-methylene)diphosphate) were not protective.	alpha,beta-methyleneadenosine 5'-diphosphate	137-143	5'-nucleotidase ecto	Homo sapiens	106-126
32045236-2	2020	Here, we present the synthesis, structure-activity relationships, and cocrystal structures of novel derivatives of the competitive CD73 inhibitor alpha,beta-methylene-ADP (AOPCP) substituted in the 2-position.	alpha,beta-methyleneadenosine 5'-diphosphate	146-170	5'-nucleotidase ecto	Homo sapiens	131-135
32595514-5	2020	Furthermore, to interfere with the endogenous adenosine release, the ecto-5"-nucleotidase (CD73) inhibitor was applied [5"-(alpha,beta-methylene) diphosphate sodium salt (AMPCP), 500 muM].	alpha,beta-methyleneadenosine 5'-diphosphate	171-176	5' nucleotidase, ecto	Rattus norvegicus	69-89
32595514-5	2020	Furthermore, to interfere with the endogenous adenosine release, the ecto-5"-nucleotidase (CD73) inhibitor was applied [5"-(alpha,beta-methylene) diphosphate sodium salt (AMPCP), 500 muM].	alpha,beta-methyleneadenosine 5'-diphosphate	171-176	5' nucleotidase, ecto	Rattus norvegicus	91-95
32045236-2	2020	Here, we present the synthesis, structure-activity relationships, and cocrystal structures of novel derivatives of the competitive CD73 inhibitor alpha,beta-methylene-ADP (AOPCP) substituted in the 2-position.	alpha,beta-methyleneadenosine 5'-diphosphate	172-177	5'-nucleotidase ecto	Homo sapiens	131-135
31237169-9	2019	This effect was blocked by adenosine 5"-(alpha, beta-methylene) diphosphate, a specific inhibitor of CD 73 and ZM 241385, an A2 adenosine receptor antagonist.	alpha,beta-methyleneadenosine 5'-diphosphate	27-75	5'-nucleotidase ecto	Homo sapiens	101-106
31394204-3	2019	Thus, CD73 inhibition with alpha,beta-methylene-ADP impaired long-term potentiation (LTP) in mouse hippocampal slices, which is occluded upon previous superfusion with the A2AR antagonist SCH58261.	alpha,beta-methyleneadenosine 5'-diphosphate	27-51	adenosine A2a receptor	Mus musculus	172-176
31220343-4	2019	EXPERIMENTAL APPROACH: Effects of blocking CD73 with alpha,beta-methylene ADP (AOPCP) were assayed in 6-OHDA-treated rats and dopamine-differentiated neuroblastoma SH-SY5Y cells.	alpha,beta-methyleneadenosine 5'-diphosphate	53-77	5' nucleotidase, ecto	Rattus norvegicus	43-47
31220343-4	2019	EXPERIMENTAL APPROACH: Effects of blocking CD73 with alpha,beta-methylene ADP (AOPCP) were assayed in 6-OHDA-treated rats and dopamine-differentiated neuroblastoma SH-SY5Y cells.	alpha,beta-methyleneadenosine 5'-diphosphate	79-84	5' nucleotidase, ecto	Rattus norvegicus	43-47
31354490-0	2019	The Ecto-5"-Nucleotidase/CD73 Inhibitor, alpha,beta-Methylene Adenosine 5"-Diphosphate, Exacerbates Carrageenan-Induced Pleurisy in Rat.	alpha,beta-methyleneadenosine 5'-diphosphate	41-86	5' nucleotidase, ecto	Rattus norvegicus	4-24
31354490-0	2019	The Ecto-5"-Nucleotidase/CD73 Inhibitor, alpha,beta-Methylene Adenosine 5"-Diphosphate, Exacerbates Carrageenan-Induced Pleurisy in Rat.	alpha,beta-methyleneadenosine 5'-diphosphate	41-86	5' nucleotidase, ecto	Rattus norvegicus	25-29
31354490-3	2019	Adenosine 5"-(alpha,beta-methylene)diphosphate (APCP) is a CD73 inhibitor, widely used as pharmacological tool to investigate the role of CD73/adenosine pathway in several in vitro and in vivo models, although it has been also shown to inhibit other ectoenzymes involved in adenosinergic pathway.	alpha,beta-methyleneadenosine 5'-diphosphate	0-46	5' nucleotidase, ecto	Rattus norvegicus	59-63
31354490-3	2019	Adenosine 5"-(alpha,beta-methylene)diphosphate (APCP) is a CD73 inhibitor, widely used as pharmacological tool to investigate the role of CD73/adenosine pathway in several in vitro and in vivo models, although it has been also shown to inhibit other ectoenzymes involved in adenosinergic pathway.	alpha,beta-methyleneadenosine 5'-diphosphate	0-46	5' nucleotidase, ecto	Rattus norvegicus	138-142
26792860-9	2016	Co-crystal structures of SMPDL3A with AMP and alpha,beta-methylene ADP (AMPCP) reveal that the substrate binding site accommodates nucleotides by establishing interactions with their base, sugar, and phosphate moieties, with the latter the major contributor to binding affinity.	alpha,beta-methyleneadenosine 5'-diphosphate	46-70	sphingomyelin phosphodiesterase, acid-like 3A	Mus musculus	25-32
30097462-6	2018	Preclinically, we reported that treatment of alpha,beta-methylene adenosine 5"-diphosphate, a potent CD73 specific inhibitor, significantly decreased sickling, hemolysis, multiorgan damage, and disease progression in the murine model of SCD.	alpha,beta-methyleneadenosine 5'-diphosphate	45-90	5' nucleotidase, ecto	Mus musculus	101-105
27417582-8	2016	However, the CD73 inhibitor alpha-beta-methylene-ADP nullified the prolongation in the time to thrombosis in human CD39 transgenic (hC39-Tg)/CD73-null mice.	alpha,beta-methyleneadenosine 5'-diphosphate	28-52	5'-nucleotidase ecto	Homo sapiens	13-17
27417582-8	2016	However, the CD73 inhibitor alpha-beta-methylene-ADP nullified the prolongation in the time to thrombosis in human CD39 transgenic (hC39-Tg)/CD73-null mice.	alpha,beta-methyleneadenosine 5'-diphosphate	28-52	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	115-119
27417582-8	2016	However, the CD73 inhibitor alpha-beta-methylene-ADP nullified the prolongation in the time to thrombosis in human CD39 transgenic (hC39-Tg)/CD73-null mice.	alpha,beta-methyleneadenosine 5'-diphosphate	28-52	5'-nucleotidase ecto	Homo sapiens	141-145
27335499-6	2016	In fact, a transient treatment with a specific CD73 inhibitor (adenosine 5"-alpha,beta-methylene-diphosphate) enhanced the microbicidal M1 subset predominance, diminished IL-4- and IL-10-producing CD4(+) T cells, promoted a proinflammatory cytokine milieu, and reduced parasite load within the myocardium during the acute phase.	alpha,beta-methyleneadenosine 5'-diphosphate	63-108	5' nucleotidase, ecto	Mus musculus	47-51
27335499-6	2016	In fact, a transient treatment with a specific CD73 inhibitor (adenosine 5"-alpha,beta-methylene-diphosphate) enhanced the microbicidal M1 subset predominance, diminished IL-4- and IL-10-producing CD4(+) T cells, promoted a proinflammatory cytokine milieu, and reduced parasite load within the myocardium during the acute phase.	alpha,beta-methyleneadenosine 5'-diphosphate	63-108	interleukin 4	Mus musculus	171-186
27335499-6	2016	In fact, a transient treatment with a specific CD73 inhibitor (adenosine 5"-alpha,beta-methylene-diphosphate) enhanced the microbicidal M1 subset predominance, diminished IL-4- and IL-10-producing CD4(+) T cells, promoted a proinflammatory cytokine milieu, and reduced parasite load within the myocardium during the acute phase.	alpha,beta-methyleneadenosine 5'-diphosphate	63-108	CD4 antigen	Mus musculus	197-200
30913879-2	2019	Here we report that in an asthma model of male Sprague-Dawley rats, the expression and activity of ecto-5"-nucleotidase (CD73) were decreased in airway vagal centers, ATP concentration in cerebral spinal fluid was increased, and the inhibitory and excitatory airway vagal responses to intracisternally injected ATP (5 mumol) and CD73 inhibitor AMPCP (5 mumol), respectively, were attenuated.	alpha,beta-methyleneadenosine 5'-diphosphate	344-349	5' nucleotidase, ecto	Rattus norvegicus	99-119
30913879-2	2019	Here we report that in an asthma model of male Sprague-Dawley rats, the expression and activity of ecto-5"-nucleotidase (CD73) were decreased in airway vagal centers, ATP concentration in cerebral spinal fluid was increased, and the inhibitory and excitatory airway vagal responses to intracisternally injected ATP (5 mumol) and CD73 inhibitor AMPCP (5 mumol), respectively, were attenuated.	alpha,beta-methyleneadenosine 5'-diphosphate	344-349	5' nucleotidase, ecto	Rattus norvegicus	121-125
28560821-9	2018	Inhibition of CD73 by alpha,beta-methylene ADP (AOPCP) in the whole CB preparation in vitro reduced basal discharge frequency by 76 +- 5% and reduced sensory activity throughout graded hypoxia.	alpha,beta-methyleneadenosine 5'-diphosphate	22-46	5'-nucleotidase ecto	Homo sapiens	14-18
28560821-9	2018	Inhibition of CD73 by alpha,beta-methylene ADP (AOPCP) in the whole CB preparation in vitro reduced basal discharge frequency by 76 +- 5% and reduced sensory activity throughout graded hypoxia.	alpha,beta-methyleneadenosine 5'-diphosphate	48-53	5'-nucleotidase ecto	Homo sapiens	14-18
29331956-9	2018	A subset of MSCs were pretreated with the CD73 inhibitor, alpha,beta-methylene adenosine diphosphate, before implantation.	alpha,beta-methyleneadenosine 5'-diphosphate	58-100	5' nucleotidase, ecto	Rattus norvegicus	42-46
26792860-9	2016	Co-crystal structures of SMPDL3A with AMP and alpha,beta-methylene ADP (AMPCP) reveal that the substrate binding site accommodates nucleotides by establishing interactions with their base, sugar, and phosphate moieties, with the latter the major contributor to binding affinity.	alpha,beta-methyleneadenosine 5'-diphosphate	72-77	sphingomyelin phosphodiesterase, acid-like 3A	Mus musculus	25-32
23300031-7	2013	Through treatment with the CD73 inhibitor adenosine 5"-(alpha, beta-methylene) diphosphate, chondrogenic matrix deposition was further increased; in contrast, mineral matrix deposition and expression of osteogenic markers was reduced.	alpha,beta-methyleneadenosine 5'-diphosphate	42-90	5'-nucleotidase ecto	Homo sapiens	27-31
26147331-0	2015	alpha,beta-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5"-Nucleotidase (CD73) Inhibitors.	alpha,beta-methyleneadenosine 5'-diphosphate	0-24	5'-nucleotidase ecto	Homo sapiens	96-116
26147331-0	2015	alpha,beta-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5"-Nucleotidase (CD73) Inhibitors.	alpha,beta-methyleneadenosine 5'-diphosphate	0-24	5'-nucleotidase ecto	Homo sapiens	118-122
26147331-0	2015	alpha,beta-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5"-Nucleotidase (CD73) Inhibitors.	alpha,beta-methyleneadenosine 5'-diphosphate	26-31	5'-nucleotidase ecto	Homo sapiens	96-116
26147331-0	2015	alpha,beta-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5"-Nucleotidase (CD73) Inhibitors.	alpha,beta-methyleneadenosine 5'-diphosphate	26-31	5'-nucleotidase ecto	Homo sapiens	118-122
26147331-3	2015	The eN inhibitor alpha,beta-methylene-ADP (AOPCP, adenosine-5"-O-[(phosphonomethyl)phosphonic acid]) was used as a lead structure, and derivatives modified in various positions were prepared.	alpha,beta-methyleneadenosine 5'-diphosphate	17-41	5'-nucleotidase ecto	Homo sapiens	4-6
26147331-3	2015	The eN inhibitor alpha,beta-methylene-ADP (AOPCP, adenosine-5"-O-[(phosphonomethyl)phosphonic acid]) was used as a lead structure, and derivatives modified in various positions were prepared.	alpha,beta-methyleneadenosine 5'-diphosphate	43-48	5'-nucleotidase ecto	Homo sapiens	4-6
25129451-6	2014	As expected, astrocytes from 5NTE (+/+) mice produced adenosine from AMP; the eN inhibitor alpha,beta-methylene ADP (AOPCP) decreased ADO formation.	alpha,beta-methyleneadenosine 5'-diphosphate	91-115	5' nucleotidase, ecto	Mus musculus	78-80
25129451-6	2014	As expected, astrocytes from 5NTE (+/+) mice produced adenosine from AMP; the eN inhibitor alpha,beta-methylene ADP (AOPCP) decreased ADO formation.	alpha,beta-methyleneadenosine 5'-diphosphate	117-122	5' nucleotidase, ecto	Mus musculus	78-80
22137869-6	2013	The treatment with APCP (alpha,beta-methyleneadenosine-5"-diphosphate), another ecto-5"-NT/CD73 inhibitor, led to a significant reduction in cell proliferation.	alpha,beta-methyleneadenosine 5'-diphosphate	25-69	5'-nucleotidase ecto	Homo sapiens	91-95
23211965-3	2013	Inhibition of ecto-5"-nucleotidase-dependent constitutive degradation of brain extracellular AMP by methylene-ADP (AMPCP) also suffices to prompt A1R-dependent hypothermia without hypotension.	alpha,beta-methyleneadenosine 5'-diphosphate	115-120	5' nucleotidase, ecto	Mus musculus	14-34