PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9352312-14	1997	These observations suggest that allocryptopine induces a relaxing effect on the ileum by inhibiting phosphodiesterase enzyme, and thus elevating cellular cAMP and its contractile effect on the urinary bladder by affecting alpha-adrenergic receptors in this tissue.	allocryptopine	32-46	cathelicidin antimicrobial peptide	Rattus norvegicus	154-158
22166397-2	2012	In this study, we examined whether M. cordata extract and/or its major alkaloid constituents, protopine, allocryptopine, sanguinarine and chelerythrine activate the Nrf2 signalling pathway which regulates the expression of cytoprotective enzymes including heme oxygenase-1 (HO-1) and thioredoxin 1.	allocryptopine	105-119	nuclear factor, erythroid derived 2, like 2	Mus musculus	165-169
21419197-3	2011	In HepG2 cells, protopine and allocryptopine significantly increased CYP1A1 mRNA levels after 24h exposure at concentrations from 25 and 10 muM, respectively, as shown by real-time PCR.	allocryptopine	30-44	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	69-75
21419197-3	2011	In HepG2 cells, protopine and allocryptopine significantly increased CYP1A1 mRNA levels after 24h exposure at concentrations from 25 and 10 muM, respectively, as shown by real-time PCR.	allocryptopine	30-44	latexin	Homo sapiens	140-143
21419197-4	2011	Both protopine and allocryptopine also dose-dependently increased CYP1A1 and CYP1A2 mRNA levels in human hepatocytes.	allocryptopine	19-33	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	66-72
21419197-4	2011	Both protopine and allocryptopine also dose-dependently increased CYP1A1 and CYP1A2 mRNA levels in human hepatocytes.	allocryptopine	19-33	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	77-83
21419197-6	2011	Using gene reporter assays performed in transiently transfected HepG2 cells, we demonstrated that the induction of CYP1A1 expression by either protopine or allocryptopine was associated with mild or negligible activation of the aryl hydrocarbon receptor.	allocryptopine	156-170	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	115-121
32535456-4	2020	This study revealed that Protopine, Allocryptopine and (+-) 6- Acetonyldihydrochelerythrine could be potential RdRp inhibitors of SARS-CoV-2.	allocryptopine	36-50	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	111-115
31789425-12	2020	Upregulation of CYP1A1 was at least partially caused by chelerythrine and allocryptopine, as shown by RT-qPCR in two HNSCC cell lines.	allocryptopine	74-88	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	16-22
25261036-0	2015	Electrophysiological and trafficking defects of the SCN5A T353I mutation in Brugada syndrome are rescued by alpha-allocryptopine.	allocryptopine	108-128	sodium voltage-gated channel alpha subunit 5	Homo sapiens	52-57
25261036-2	2015	Here, we investigate the rescue effect of alpha-allocryptopine (All) from Chinese herbal medicine in a T353I mutation of SCN5A, which combines trafficking abnormalities with Brugada syndrome.	allocryptopine	42-62	sodium voltage-gated channel alpha subunit 5	Homo sapiens	121-126
25261036-2	2015	Here, we investigate the rescue effect of alpha-allocryptopine (All) from Chinese herbal medicine in a T353I mutation of SCN5A, which combines trafficking abnormalities with Brugada syndrome.	allocryptopine	64-67	sodium voltage-gated channel alpha subunit 5	Homo sapiens	121-126