PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
20171860-9	2010	These results suggest that spinosin may be an antagonist at postsynaptic 5-HT(1A) receptors because these effects of 8-OH-DPAT were considered to be mediated via postsynaptic 5-HT(1A) receptors.	spinosin	27-35	5-hydroxytryptamine receptor 1A	Rattus norvegicus	73-80
20171860-0	2010	Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT(1A) receptors.	spinosin	23-31	5-hydroxytryptamine receptor 1A	Rattus norvegicus	146-153
20171860-9	2010	These results suggest that spinosin may be an antagonist at postsynaptic 5-HT(1A) receptors because these effects of 8-OH-DPAT were considered to be mediated via postsynaptic 5-HT(1A) receptors.	spinosin	27-35	5-hydroxytryptamine receptor 1A	Rattus norvegicus	175-182
20171860-12	2010	These results suggest that the effect of spinosin on REM sleep in pentobarbital-treated rats may be related to postsynaptic 5-HT(1A) receptors.	spinosin	41-49	5-hydroxytryptamine receptor 1A	Rattus norvegicus	124-131
32667705-0	2020	Spinosin protects N2a cells from H2 O2 -induced neurotoxicity through inactivation of p38MAPK.	spinosin	0-8	mitogen-activated protein kinase 14	Mus musculus	86-93
31791116-0	2020	Spinosin Inhibits Abeta1-42 Production and Aggregation via Activating Nrf2/HO-1 Pathway.	spinosin	0-8	heme oxygenase 1	Mus musculus	75-79
32380350-6	2020	The results showed that IL-1beta expression of RAW 264.7 cells treated with spinosin and melittoside as well as the TNF-alpha level of RAW 264.7 cells treated with rehmannioside D and melittoside were not significantly different compared with lipopolysaccharide (LPS)-treated cells.	spinosin	76-84	interleukin 1 alpha	Mus musculus	24-32
31791116-0	2020	Spinosin Inhibits Abeta1-42 Production and Aggregation via Activating Nrf2/HO-1 Pathway.	spinosin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	70-74
31791116-1	2020	The present research work primarily investigated whether spinosin has the potential of improving the pathogenesis of Alzheimer"s disease (AD) driven by beta-amyloid (Abeta) overproduction through impacting the procession of amyloid precursor protein (APP).	spinosin	57-65	amyloid beta (A4) precursor protein	Mus musculus	224-249
31791116-5	2020	The results showed that ROS induced the expression of ADAM10 and reduced the expression of BACE1, while spinosin inhibited ROS production by activating Nrf2 and up-regulating the expression of HO-1.	spinosin	104-112	nuclear factor, erythroid derived 2, like 2	Mus musculus	152-156
31791116-5	2020	The results showed that ROS induced the expression of ADAM10 and reduced the expression of BACE1, while spinosin inhibited ROS production by activating Nrf2 and up-regulating the expression of HO-1.	spinosin	104-112	heme oxygenase 1	Mus musculus	193-197
31791116-8	2020	In conclusion, spinosin reduced Abeta1-42 production by activating the Nrf2/HO-1 pathway in N2a/WT and N2a/ APP695 cells.	spinosin	15-23	nuclear factor, erythroid derived 2, like 2	Mus musculus	71-75
31791116-8	2020	In conclusion, spinosin reduced Abeta1-42 production by activating the Nrf2/HO-1 pathway in N2a/WT and N2a/ APP695 cells.	spinosin	15-23	heme oxygenase 1	Mus musculus	76-80
29925225-6	2019	Abeta1-42 induced alterations in the expression of brain derived neurotrophic factor (BDNF) and B-cell lymphoma-2 (Bcl-2), as well as inflammatory response in brain were also reversed by spinosin treatment.	spinosin	187-195	brain derived neurotrophic factor	Mus musculus	51-84
31545438-9	2019	In addition, spinosin treatment increased light chain 3B-II and 6"""-feruloylspinosin, and reduced p62, indicating that autophagy was promoted after drug treatments.	spinosin	13-21	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	99-102
31545438-10	2019	Treatments of spinosin and 6"""-feruloylspinosin led to the reduction of glycogen synthase kinase-3beta (GSK3beta) phosphorylation at Tyr216, and the increase of peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha and its downstream signaling proteins, including nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and hemeoxygenase1 (HO-1).	spinosin	14-22	glycogen synthase kinase 3 beta	Rattus norvegicus	73-103
31545438-10	2019	Treatments of spinosin and 6"""-feruloylspinosin led to the reduction of glycogen synthase kinase-3beta (GSK3beta) phosphorylation at Tyr216, and the increase of peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha and its downstream signaling proteins, including nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and hemeoxygenase1 (HO-1).	spinosin	14-22	glycogen synthase kinase 3 alpha	Rattus norvegicus	105-113
31545438-10	2019	Treatments of spinosin and 6"""-feruloylspinosin led to the reduction of glycogen synthase kinase-3beta (GSK3beta) phosphorylation at Tyr216, and the increase of peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha and its downstream signaling proteins, including nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and hemeoxygenase1 (HO-1).	spinosin	14-22	PPARG coactivator 1 alpha	Rattus norvegicus	162-235
31545438-10	2019	Treatments of spinosin and 6"""-feruloylspinosin led to the reduction of glycogen synthase kinase-3beta (GSK3beta) phosphorylation at Tyr216, and the increase of peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha and its downstream signaling proteins, including nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and hemeoxygenase1 (HO-1).	spinosin	14-22	NFE2 like bZIP transcription factor 2	Rattus norvegicus	285-328
31545438-10	2019	Treatments of spinosin and 6"""-feruloylspinosin led to the reduction of glycogen synthase kinase-3beta (GSK3beta) phosphorylation at Tyr216, and the increase of peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha and its downstream signaling proteins, including nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and hemeoxygenase1 (HO-1).	spinosin	14-22	NFE2 like bZIP transcription factor 2	Rattus norvegicus	330-334
31724150-0	2020	Reduced c-Fos expression in orexin neurons of the lateral hypothalamic area and the locus coeruleus following injection of spinosin into mice.	spinosin	123-131	FBJ osteosarcoma oncogene	Mus musculus	8-13
31724150-0	2020	Reduced c-Fos expression in orexin neurons of the lateral hypothalamic area and the locus coeruleus following injection of spinosin into mice.	spinosin	123-131	hypocretin	Mus musculus	28-34
31724150-5	2020	Unlike saline, spinosin markedly decreased c-Fos expression in the lateral hypothalamic area (LHA) as well as the locus coeruleus (LC).	spinosin	15-23	FBJ osteosarcoma oncogene	Mus musculus	43-48
31724150-6	2020	Compared to the saline injection, the application of spinosin also resulted in a marked decrease in c-Fos expression in the LHA orexin neurons.	spinosin	53-61	FBJ osteosarcoma oncogene	Mus musculus	100-105
31724150-6	2020	Compared to the saline injection, the application of spinosin also resulted in a marked decrease in c-Fos expression in the LHA orexin neurons.	spinosin	53-61	hypocretin	Mus musculus	128-134
31724150-7	2020	CONCLUSIONS: These findings suggest that spinosin administration results in a restricted pattern of c-Fos expression within the LHA orexin neurons and the LC, suggesting that this particular neuronal inactivation contributes to sedation and hypnosis.	spinosin	41-49	FBJ osteosarcoma oncogene	Mus musculus	100-105
31724150-7	2020	CONCLUSIONS: These findings suggest that spinosin administration results in a restricted pattern of c-Fos expression within the LHA orexin neurons and the LC, suggesting that this particular neuronal inactivation contributes to sedation and hypnosis.	spinosin	41-49	hypocretin	Mus musculus	132-138
29925225-6	2019	Abeta1-42 induced alterations in the expression of brain derived neurotrophic factor (BDNF) and B-cell lymphoma-2 (Bcl-2), as well as inflammatory response in brain were also reversed by spinosin treatment.	spinosin	187-195	brain derived neurotrophic factor	Mus musculus	86-90
29925225-6	2019	Abeta1-42 induced alterations in the expression of brain derived neurotrophic factor (BDNF) and B-cell lymphoma-2 (Bcl-2), as well as inflammatory response in brain were also reversed by spinosin treatment.	spinosin	187-195	B cell leukemia/lymphoma 2	Mus musculus	96-113
29925225-6	2019	Abeta1-42 induced alterations in the expression of brain derived neurotrophic factor (BDNF) and B-cell lymphoma-2 (Bcl-2), as well as inflammatory response in brain were also reversed by spinosin treatment.	spinosin	187-195	B cell leukemia/lymphoma 2	Mus musculus	115-120
29925225-7	2019	These results indicated that the ameliorating effect of spinosin on cognitive impairment might be mediated through the regulation of oxidative stress, inflammatory process, apoptotic program and neurotrophic factor expression, suggesting that spinosin might be beneficial to treat learning and memory deficits in patients with AD via multi-targets.	spinosin	56-64	neurotrophin 3	Homo sapiens	195-214
29925225-7	2019	These results indicated that the ameliorating effect of spinosin on cognitive impairment might be mediated through the regulation of oxidative stress, inflammatory process, apoptotic program and neurotrophic factor expression, suggesting that spinosin might be beneficial to treat learning and memory deficits in patients with AD via multi-targets.	spinosin	243-251	neurotrophin 3	Homo sapiens	195-214
28513155-7	2017	Spinosin and swertisin could improve mRNA transcription levels of glutamate receptor K1, K2, and K3 (GluK1, GluK2, and GluK3) subunits in rat hippocampal neurons.	spinosin	0-8	keratin 1	Rattus norvegicus	85-99
28513155-7	2017	Spinosin and swertisin could improve mRNA transcription levels of glutamate receptor K1, K2, and K3 (GluK1, GluK2, and GluK3) subunits in rat hippocampal neurons.	spinosin	0-8	glutamate ionotropic receptor kainate type subunit 1	Rattus norvegicus	101-106
28513155-7	2017	Spinosin and swertisin could improve mRNA transcription levels of glutamate receptor K1, K2, and K3 (GluK1, GluK2, and GluK3) subunits in rat hippocampal neurons.	spinosin	0-8	glutamate ionotropic receptor kainate type subunit 2	Rattus norvegicus	108-113
28513155-7	2017	Spinosin and swertisin could improve mRNA transcription levels of glutamate receptor K1, K2, and K3 (GluK1, GluK2, and GluK3) subunits in rat hippocampal neurons.	spinosin	0-8	glutamate ionotropic receptor kainate type subunit 3	Rattus norvegicus	119-124
26780157-9	2016	In addition, both 6"""-feruloylspinosin and spinosin could enhance the expression of GABAAalpha1, GABAAalpha5, GABABR1 mRNA in rat hippocampal neurons significantly, indicating the bioactivity mechanism of 6"""-feruloylspinosin was involved in the GABA receptors.	spinosin	31-39	gamma-aminobutyric acid type B receptor subunit 1	Rattus norvegicus	111-118
26997033-6	2016	In addition, we observed an increase in the percentage of BrdU-incorporated cells co-localized with NeuN, a mature neuronal marker, which indicated that spinosin stimulates the differentiation of newly generated cells into mature neurons.	spinosin	153-161	RNA binding protein, fox-1 homolog (C. elegans) 3	Mus musculus	100-104
26997033-7	2016	Also, the subchronic treatment with spinosin (5mg/kg) increased the expression levels of phosphorylated extracellular-regulated kinase (ERK), phosphorylated cAMP response element-binding protein (CREB) and mature brain-derived neurotrophic factor (mBDNF) in the hippocampus.	spinosin	36-44	mitogen-activated protein kinase 1	Mus musculus	104-134
26997033-7	2016	Also, the subchronic treatment with spinosin (5mg/kg) increased the expression levels of phosphorylated extracellular-regulated kinase (ERK), phosphorylated cAMP response element-binding protein (CREB) and mature brain-derived neurotrophic factor (mBDNF) in the hippocampus.	spinosin	36-44	mitogen-activated protein kinase 1	Mus musculus	136-139
26997033-7	2016	Also, the subchronic treatment with spinosin (5mg/kg) increased the expression levels of phosphorylated extracellular-regulated kinase (ERK), phosphorylated cAMP response element-binding protein (CREB) and mature brain-derived neurotrophic factor (mBDNF) in the hippocampus.	spinosin	36-44	cAMP responsive element binding protein 1	Mus musculus	157-194
26997033-7	2016	Also, the subchronic treatment with spinosin (5mg/kg) increased the expression levels of phosphorylated extracellular-regulated kinase (ERK), phosphorylated cAMP response element-binding protein (CREB) and mature brain-derived neurotrophic factor (mBDNF) in the hippocampus.	spinosin	36-44	cAMP responsive element binding protein 1	Mus musculus	196-200
26997033-7	2016	Also, the subchronic treatment with spinosin (5mg/kg) increased the expression levels of phosphorylated extracellular-regulated kinase (ERK), phosphorylated cAMP response element-binding protein (CREB) and mature brain-derived neurotrophic factor (mBDNF) in the hippocampus.	spinosin	36-44	brain derived neurotrophic factor	Mus musculus	213-246
26997033-7	2016	Also, the subchronic treatment with spinosin (5mg/kg) increased the expression levels of phosphorylated extracellular-regulated kinase (ERK), phosphorylated cAMP response element-binding protein (CREB) and mature brain-derived neurotrophic factor (mBDNF) in the hippocampus.	spinosin	36-44	brain derived neurotrophic factor	Mus musculus	248-253
26997033-8	2016	These findings demonstrate that spinosin has the potential for therapeutic use in treating the cognitive dysfunction observed in neurological or psychiatric disorders by up-regulating adult hippocampal neurogenesis or activating of the ERK-CREB-BDNF signaling pathway.	spinosin	32-40	mitogen-activated protein kinase 1	Mus musculus	236-239
26997033-8	2016	These findings demonstrate that spinosin has the potential for therapeutic use in treating the cognitive dysfunction observed in neurological or psychiatric disorders by up-regulating adult hippocampal neurogenesis or activating of the ERK-CREB-BDNF signaling pathway.	spinosin	32-40	cAMP responsive element binding protein 1	Mus musculus	240-244
26997033-8	2016	These findings demonstrate that spinosin has the potential for therapeutic use in treating the cognitive dysfunction observed in neurological or psychiatric disorders by up-regulating adult hippocampal neurogenesis or activating of the ERK-CREB-BDNF signaling pathway.	spinosin	32-40	brain derived neurotrophic factor	Mus musculus	245-249
25767684-12	2015	In addition, spinosin rescued the AbetaO-induced decrease in choline acetyltransferase expression levels.	spinosin	13-21	choline acetyltransferase	Mus musculus	61-86
22221104-0	2012	Augmentative effect of spinosin on pentobarbital-induced loss of righting reflex in mice associated with presynaptic 5-HT1A receptor.	spinosin	23-31	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	117-132
22221104-12	2012	On the other hand, spinosin inhibited 8-OH-DPAT-induced hypothermia, which has been generally attributed to the activation of somatodendritic 5-HT(1A) autoreceptors in mice.	spinosin	19-27	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	142-149
22221104-13	2012	CONCLUSIONS: Based on our previous results and the present data, it should be presumed that presynaptic 5-HT(1A) autoreceptor mechanisms may be involved in the inhibitory effect of spinosin on 8-OH-DPAT-induced hypothermia and also in the potentiating effect of spinosin on pentobarbital-induced LORR in mice.	spinosin	181-189	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	104-111
22221104-13	2012	CONCLUSIONS: Based on our previous results and the present data, it should be presumed that presynaptic 5-HT(1A) autoreceptor mechanisms may be involved in the inhibitory effect of spinosin on 8-OH-DPAT-induced hypothermia and also in the potentiating effect of spinosin on pentobarbital-induced LORR in mice.	spinosin	262-270	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	104-111
22169469-9	2012	These results demonstrated that the CsA decreased the efflux of spinosin through the inhibition of P-glycoprotein (P-gp) efflux transporter and it might be used as a group of P-gp substrate.	spinosin	64-72	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	99-113