PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26988989-8	2016	We show that DeltaNp63alpha-mediated repression of miR-527/665 controls a TGFbeta-dependent signaling node that switches off antimigratory miR-198 by suppressing the expression of the regulatory factor, KSRP (KHSRP).	deltanp63alpha	13-27	microRNA 527	Homo sapiens	51-58
28468801-0	2017	DeltaNp63alpha is a common inhibitory target in oncogenic PI3K/Ras/Her2-induced cell motility and tumor metastasis.	deltanp63alpha	0-14	erb-b2 receptor tyrosine kinase 2	Homo sapiens	67-71
28468801-7	2017	Together, these results demonstrate that DeltaNp63alpha is a common inhibitory target of oncogenic PI3K, Ras, and Her2, and that DeltaNp63alpha may function as a critical integrator of oncogenic signaling in cancer metastasis.	deltanp63alpha	41-55	erb-b2 receptor tyrosine kinase 2	Homo sapiens	114-118
28368419-0	2017	DeltaNp63alpha promotes adhesion of metastatic prostate cancer cells to the bone through regulation of CD82.	deltanp63alpha	0-14	CD82 molecule	Homo sapiens	103-107
26988989-8	2016	We show that DeltaNp63alpha-mediated repression of miR-527/665 controls a TGFbeta-dependent signaling node that switches off antimigratory miR-198 by suppressing the expression of the regulatory factor, KSRP (KHSRP).	deltanp63alpha	13-27	transforming growth factor beta 1	Homo sapiens	74-81
26988989-8	2016	We show that DeltaNp63alpha-mediated repression of miR-527/665 controls a TGFbeta-dependent signaling node that switches off antimigratory miR-198 by suppressing the expression of the regulatory factor, KSRP (KHSRP).	deltanp63alpha	13-27	microRNA 198	Homo sapiens	139-146
26988989-8	2016	We show that DeltaNp63alpha-mediated repression of miR-527/665 controls a TGFbeta-dependent signaling node that switches off antimigratory miR-198 by suppressing the expression of the regulatory factor, KSRP (KHSRP).	deltanp63alpha	13-27	KH-type splicing regulatory protein	Homo sapiens	203-207
26988989-8	2016	We show that DeltaNp63alpha-mediated repression of miR-527/665 controls a TGFbeta-dependent signaling node that switches off antimigratory miR-198 by suppressing the expression of the regulatory factor, KSRP (KHSRP).	deltanp63alpha	13-27	KH-type splicing regulatory protein	Homo sapiens	209-214
27081041-0	2016	DeltaNp63alpha induces the expression of FAT2 and Slug to promote tumor invasion.	deltanp63alpha	0-14	FAT atypical cadherin 2	Homo sapiens	41-45
27081041-0	2016	DeltaNp63alpha induces the expression of FAT2 and Slug to promote tumor invasion.	deltanp63alpha	0-14	snail family transcriptional repressor 2	Homo sapiens	50-54
27081041-4	2016	Here, using gene expression analysis, ChIP-seq, and functional testing, we find that DeltaNp63alpha promotes BLBC motility by inducing the expression of the atypical cadherin FAT2, the vesicular binding protein SNCA, the carbonic anhydrase CA12, the lipid binding protein CPNE8 and the kinase NEK1, along with Slug and Axl.	deltanp63alpha	85-99	FAT atypical cadherin 2	Homo sapiens	175-179
26704768-0	2016	DeltaNp63alpha induces quiescence and downregulates the BRCA1 pathway in estrogen receptor-positive luminal breast cancer cell line MCF7 but not in other breast cancer cell lines.	deltanp63alpha	0-14	BRCA1 DNA repair associated	Homo sapiens	56-61
27081041-4	2016	Here, using gene expression analysis, ChIP-seq, and functional testing, we find that DeltaNp63alpha promotes BLBC motility by inducing the expression of the atypical cadherin FAT2, the vesicular binding protein SNCA, the carbonic anhydrase CA12, the lipid binding protein CPNE8 and the kinase NEK1, along with Slug and Axl.	deltanp63alpha	85-99	synuclein alpha	Homo sapiens	211-215
27081041-4	2016	Here, using gene expression analysis, ChIP-seq, and functional testing, we find that DeltaNp63alpha promotes BLBC motility by inducing the expression of the atypical cadherin FAT2, the vesicular binding protein SNCA, the carbonic anhydrase CA12, the lipid binding protein CPNE8 and the kinase NEK1, along with Slug and Axl.	deltanp63alpha	85-99	carbonic anhydrase 12	Homo sapiens	240-244
27081041-4	2016	Here, using gene expression analysis, ChIP-seq, and functional testing, we find that DeltaNp63alpha promotes BLBC motility by inducing the expression of the atypical cadherin FAT2, the vesicular binding protein SNCA, the carbonic anhydrase CA12, the lipid binding protein CPNE8 and the kinase NEK1, along with Slug and Axl.	deltanp63alpha	85-99	copine 8	Homo sapiens	272-277
27081041-4	2016	Here, using gene expression analysis, ChIP-seq, and functional testing, we find that DeltaNp63alpha promotes BLBC motility by inducing the expression of the atypical cadherin FAT2, the vesicular binding protein SNCA, the carbonic anhydrase CA12, the lipid binding protein CPNE8 and the kinase NEK1, along with Slug and Axl.	deltanp63alpha	85-99	NIMA related kinase 1	Homo sapiens	293-297
27081041-4	2016	Here, using gene expression analysis, ChIP-seq, and functional testing, we find that DeltaNp63alpha promotes BLBC motility by inducing the expression of the atypical cadherin FAT2, the vesicular binding protein SNCA, the carbonic anhydrase CA12, the lipid binding protein CPNE8 and the kinase NEK1, along with Slug and Axl.	deltanp63alpha	85-99	snail family transcriptional repressor 2	Homo sapiens	310-314
27081041-4	2016	Here, using gene expression analysis, ChIP-seq, and functional testing, we find that DeltaNp63alpha promotes BLBC motility by inducing the expression of the atypical cadherin FAT2, the vesicular binding protein SNCA, the carbonic anhydrase CA12, the lipid binding protein CPNE8 and the kinase NEK1, along with Slug and Axl.	deltanp63alpha	85-99	AXL receptor tyrosine kinase	Homo sapiens	319-322
26704768-3	2016	Since DeltaNp63alpha, an isoform of p51/p63, is crucial in the maintenance of stem cells within mammary epithelium, we investigated its roles in the regulation of dormancy in normal and malignant breast cells.	deltanp63alpha	6-20	tumor protein p63	Homo sapiens	36-39
24901051-0	2014	DeltaNp63alpha activates CD82 metastasis suppressor to inhibit cancer cell invasion.	deltanp63alpha	0-14	CD82 molecule	Homo sapiens	25-29
26890356-4	2016	Although DeltaNp63alpha, the most abundant isoform of p63, appeared to interact with protein phosphatase PP2A, neither GSK-3beta phosphorylation nor beta-catenin nuclear localization was altered by the loss of p63.	deltanp63alpha	9-23	protein phosphatase 2 phosphatase activator	Homo sapiens	105-109
26890356-4	2016	Although DeltaNp63alpha, the most abundant isoform of p63, appeared to interact with protein phosphatase PP2A, neither GSK-3beta phosphorylation nor beta-catenin nuclear localization was altered by the loss of p63.	deltanp63alpha	9-23	tumor protein p63	Homo sapiens	54-57
26890356-11	2016	The combined results indicate that DeltaNp63alpha serves as a repressor that regulates beta-catenin-mediated gene expression.	deltanp63alpha	35-49	catenin beta 1	Homo sapiens	87-99
26292362-4	2015	Through a combination of expression analysis and functional testing across multiple BLBC cell populations, we determined that DeltaNp63alpha induces migration by elevating the expression of the EMT program components Slug and Axl.	deltanp63alpha	126-140	snail family transcriptional repressor 2	Homo sapiens	217-221
26292362-4	2015	Through a combination of expression analysis and functional testing across multiple BLBC cell populations, we determined that DeltaNp63alpha induces migration by elevating the expression of the EMT program components Slug and Axl.	deltanp63alpha	126-140	AXL receptor tyrosine kinase	Homo sapiens	226-229
26068789-0	2015	1alpha, 25-Dihydroxyvitamin D3 and the vitamin D receptor regulates DeltaNp63alpha levels and keratinocyte proliferation.	deltanp63alpha	68-82	vitamin D receptor	Homo sapiens	39-57
23246965-0	2014	DeltaNp63alpha regulates Erk signaling via MKP3 to inhibit cancer metastasis.	deltanp63alpha	0-14	mitogen-activated protein kinase 1	Homo sapiens	25-28
23246965-0	2014	DeltaNp63alpha regulates Erk signaling via MKP3 to inhibit cancer metastasis.	deltanp63alpha	0-14	dual specificity phosphatase 6	Homo sapiens	43-47
23246965-4	2014	We show that DeltaNp63alpha regulates extracellular signal-regulated protein kinases 1 and 2 (Erk1/2) activity via MKP3 in both cancer and non-transformed cells.	deltanp63alpha	13-27	mitogen-activated protein kinase 3	Homo sapiens	94-100
23246965-4	2014	We show that DeltaNp63alpha regulates extracellular signal-regulated protein kinases 1 and 2 (Erk1/2) activity via MKP3 in both cancer and non-transformed cells.	deltanp63alpha	13-27	dual specificity phosphatase 6	Homo sapiens	115-119
23589096-0	2013	DeltaNp63alpha represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes.	deltanp63alpha	0-14	phosphatase and tensin homolog	Homo sapiens	50-54
23589096-0	2013	DeltaNp63alpha represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes.	deltanp63alpha	0-14	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	72-79
23589096-2	2013	The goal of this study was to define the mechanisms by which DeltaNp63alpha mediates the nuclear exclusion of PTEN.	deltanp63alpha	61-75	phosphatase and tensin homolog	Homo sapiens	110-114
23589096-3	2013	We demonstrate here that DeltaNp63alpha reduces the ubiquitination of PTEN, a key signaling event in the nuclear translocation of PTEN.	deltanp63alpha	25-39	phosphatase and tensin homolog	Homo sapiens	70-74
23589096-3	2013	We demonstrate here that DeltaNp63alpha reduces the ubiquitination of PTEN, a key signaling event in the nuclear translocation of PTEN.	deltanp63alpha	25-39	phosphatase and tensin homolog	Homo sapiens	130-134
23589096-4	2013	The decrease in ubiquitinated PTEN correlated with the ability of DeltaNp63alpha to bind to neuronal precursor developmentally down regulated 4 (NEDD4) promoter and transcriptionally repress the E3 ubiquitin ligase NEDD4-1.	deltanp63alpha	66-80	phosphatase and tensin homolog	Homo sapiens	30-34
23589096-4	2013	The decrease in ubiquitinated PTEN correlated with the ability of DeltaNp63alpha to bind to neuronal precursor developmentally down regulated 4 (NEDD4) promoter and transcriptionally repress the E3 ubiquitin ligase NEDD4-1.	deltanp63alpha	66-80	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	145-150
23589096-4	2013	The decrease in ubiquitinated PTEN correlated with the ability of DeltaNp63alpha to bind to neuronal precursor developmentally down regulated 4 (NEDD4) promoter and transcriptionally repress the E3 ubiquitin ligase NEDD4-1.	deltanp63alpha	66-80	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	215-222
23219093-10	2013	In cultured cells, the GJB6 expression was significantly upregulated by DeltaNp63alpha isoform.	deltanp63alpha	72-86	gap junction protein beta 6	Homo sapiens	23-27
21088498-4	2010	We show that DeltaNp63alpha interacts with NF-kappaBeta in presence of cisplatin.	deltanp63alpha	13-27	nuclear factor kappa B subunit 1	Homo sapiens	43-55
21751214-9	2012	Likewise, Hsp70-1 expression decreased in HLE cells after addition of deltaNp63alpha SiRNA.	deltanp63alpha	70-84	heat shock protein family A (Hsp70) member 1A	Homo sapiens	10-17
23166821-0	2012	Phosphorylation of DeltaNp63alpha via a novel TGFbeta/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFbeta.	deltanp63alpha	19-33	transforming growth factor beta 1	Homo sapiens	46-53
23166821-0	2012	Phosphorylation of DeltaNp63alpha via a novel TGFbeta/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFbeta.	deltanp63alpha	19-33	transforming growth factor beta receptor 1	Homo sapiens	54-58
23166821-0	2012	Phosphorylation of DeltaNp63alpha via a novel TGFbeta/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFbeta.	deltanp63alpha	19-33	transforming growth factor beta 1	Homo sapiens	119-126
23166821-8	2012	In this study, we demonstrate that ALK5-mediated phosphorylation of DeltaNp63alpha is required for the anti-clonogenic effects of TGFBeta and ectopic expression of ALK5(IKD) mimics these effects.	deltanp63alpha	68-82	transforming growth factor beta receptor 1	Homo sapiens	35-39
23166821-8	2012	In this study, we demonstrate that ALK5-mediated phosphorylation of DeltaNp63alpha is required for the anti-clonogenic effects of TGFBeta and ectopic expression of ALK5(IKD) mimics these effects.	deltanp63alpha	68-82	transforming growth factor beta 1	Homo sapiens	130-137
21880709-2	2011	Here we demonstrate that DeltaNp63alpha, a p63 isoform lacking the N-terminal transactivation domain, induces epithelial-mesenchymal transition (EMT) in primary human keratinocytes in a TGF-beta-dependent manner.	deltanp63alpha	25-39	transforming growth factor beta 1	Homo sapiens	186-194
21880709-6	2011	Treatment with exogenous TGF-beta accelerated EMT in presenescent DeltaNp63alpha-transduced cells, whereas the inhibition of TGF-beta signaling reversed the EMT phenotype.	deltanp63alpha	66-80	transforming growth factor beta 1	Homo sapiens	25-33
22053213-0	2011	DeltaNp63alpha-mediated induction of epidermal growth factor receptor promotes pancreatic cancer cell growth and chemoresistance.	deltanp63alpha	0-14	epidermal growth factor receptor	Homo sapiens	37-69
22053213-7	2011	Epidermal growth factor receptor (EGFR) signaling pathways contribute to the biological aggressiveness of PDAC, and we found that the motogenic effects of DeltaNp63alpha were augmented in presence of EGF.	deltanp63alpha	155-169	epidermal growth factor receptor	Homo sapiens	0-32
22053213-7	2011	Epidermal growth factor receptor (EGFR) signaling pathways contribute to the biological aggressiveness of PDAC, and we found that the motogenic effects of DeltaNp63alpha were augmented in presence of EGF.	deltanp63alpha	155-169	epidermal growth factor receptor	Homo sapiens	34-38
22053213-10	2011	DeltaNp63alpha potentiated EGF-mediated activation of ERK, Akt and JNK signaling.	deltanp63alpha	0-14	AKT serine/threonine kinase 1	Homo sapiens	59-62
22053213-10	2011	DeltaNp63alpha potentiated EGF-mediated activation of ERK, Akt and JNK signaling.	deltanp63alpha	0-14	mitogen-activated protein kinase 8	Homo sapiens	67-70
23243027-4	2013	We report that DeltaNp63alpha activates bone morphogenic proteins (BMP) signaling by inducing the expression of BMP7.	deltanp63alpha	15-29	bone morphogenetic protein 7	Mus musculus	67-70
23243027-4	2013	We report that DeltaNp63alpha activates bone morphogenic proteins (BMP) signaling by inducing the expression of BMP7.	deltanp63alpha	15-29	bone morphogenetic protein 7	Mus musculus	112-116
23243027-11	2013	These studies support a model in which DeltaNp63alpha-mediated activation of BMP signaling governs epithelial cell plasticity, EMT, and tumorigenicity during breast cancer initiation and progression.	deltanp63alpha	39-53	bone morphogenetic protein 7	Mus musculus	77-80
21602882-11	2011	These results indicate DeltaNp63alpha as a novel target of HIPK2 in response to genotoxic drugs.	deltanp63alpha	23-37	homeodomain interacting protein kinase 2	Homo sapiens	59-64
21912215-0	2011	DeltaNp63alpha promotes cellular quiescence via induction and activation of Notch3.	deltanp63alpha	0-14	notch receptor 3	Homo sapiens	76-82
21527555-3	2011	The major protein isoform of p63 expressed in SCC is DeltaNp63alpha, an N-terminally truncated form which functions as a key SCC cell survival factor by mechanisms that are unclear.	deltanp63alpha	53-67	serpin family B member 3	Homo sapiens	46-49
21527555-3	2011	The major protein isoform of p63 expressed in SCC is DeltaNp63alpha, an N-terminally truncated form which functions as a key SCC cell survival factor by mechanisms that are unclear.	deltanp63alpha	53-67	serpin family B member 3	Homo sapiens	125-128
21088498-8	2010	These data demonstrate that NF-kappaBeta plays an essential role in regulating DeltaNp63alpha in response to extrinsic stimuli.	deltanp63alpha	79-93	nuclear factor kappa B subunit 1	Homo sapiens	28-40
20145131-5	2010	We found that DeltaNp63alpha interacts with IkappaB kinase (IKK), a multisubunit protein kinase that consists of two catalytic subunits, IKKalpha and IKKbeta, and a regulatory subunit, IKKgamma.	deltanp63alpha	14-28	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	137-145
20085233-9	2010	Interaction of DeltaNp63alpha with hnRNPQ, hnRNPK and FUS/TLS was confirmed by reciprocal co-immunoprecipitations in human keratinocytes.	deltanp63alpha	15-29	synaptotagmin binding cytoplasmic RNA interacting protein	Homo sapiens	35-41
20085233-9	2010	Interaction of DeltaNp63alpha with hnRNPQ, hnRNPK and FUS/TLS was confirmed by reciprocal co-immunoprecipitations in human keratinocytes.	deltanp63alpha	15-29	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	43-49
20085233-9	2010	Interaction of DeltaNp63alpha with hnRNPQ, hnRNPK and FUS/TLS was confirmed by reciprocal co-immunoprecipitations in human keratinocytes.	deltanp63alpha	15-29	FUS RNA binding protein	Homo sapiens	54-61
20145131-5	2010	We found that DeltaNp63alpha interacts with IkappaB kinase (IKK), a multisubunit protein kinase that consists of two catalytic subunits, IKKalpha and IKKbeta, and a regulatory subunit, IKKgamma.	deltanp63alpha	14-28	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	150-157
20145131-5	2010	We found that DeltaNp63alpha interacts with IkappaB kinase (IKK), a multisubunit protein kinase that consists of two catalytic subunits, IKKalpha and IKKbeta, and a regulatory subunit, IKKgamma.	deltanp63alpha	14-28	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	185-193
20145131-9	2010	Our findings show that IKKbeta plays an essential role in regulating DeltaNp63alpha in response to extrinsic stimuli.	deltanp63alpha	69-83	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	23-30
19934319-2	2009	In the normal urothelium, urothelial cells in the basal layers abundantly express the predominant p63 isoform DeltaNp63alpha.	deltanp63alpha	110-124	tumor protein p63	Homo sapiens	98-101
21364617-3	2010	Phopshorylation by c-Abl results in greater protein stability of both ectopically expressed and endogenous DeltaNp63alpha.	deltanp63alpha	107-121	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	19-24
18806757-8	2008	The knockdown of WWP1 by siRNA increases the endogenous DeltaNp63alpha level in the MCF10A and 184B5 immortalized breast epithelial cell lines and confers resistance to doxorubicin-induced apoptosis.	deltanp63alpha	56-70	WW domain containing E3 ubiquitin protein ligase 1	Homo sapiens	17-21
18849344-5	2008	In contrast, DeltaNp63alpha induced keratin 1 (K1), which is expressed at the start of differentiation, via c-Jun N-terminal kinase (JNK)/AP-1 activation.	deltanp63alpha	13-27	keratin 1	Homo sapiens	36-45
18849344-5	2008	In contrast, DeltaNp63alpha induced keratin 1 (K1), which is expressed at the start of differentiation, via c-Jun N-terminal kinase (JNK)/AP-1 activation.	deltanp63alpha	13-27	keratin 1	Homo sapiens	47-49
18849344-5	2008	In contrast, DeltaNp63alpha induced keratin 1 (K1), which is expressed at the start of differentiation, via c-Jun N-terminal kinase (JNK)/AP-1 activation.	deltanp63alpha	13-27	mitogen-activated protein kinase 8	Homo sapiens	108-131
18849344-5	2008	In contrast, DeltaNp63alpha induced keratin 1 (K1), which is expressed at the start of differentiation, via c-Jun N-terminal kinase (JNK)/AP-1 activation.	deltanp63alpha	13-27	mitogen-activated protein kinase 8	Homo sapiens	133-136
19555433-5	2009	We found that DeltaNp63alpha contributes to epidermal barrier formation by directly inducing expression of ALOX12, a lipoxygenase which contributes to epidermal barrier function.	deltanp63alpha	14-28	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	107-113
19555433-8	2009	Finally, we found that DeltaNp63alpha can induce Alox12 expression only in differentiating keratinocytes, consistent with the role of ALOX12 in epidermal barrier formation.	deltanp63alpha	23-37	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	49-55
19555433-8	2009	Finally, we found that DeltaNp63alpha can induce Alox12 expression only in differentiating keratinocytes, consistent with the role of ALOX12 in epidermal barrier formation.	deltanp63alpha	23-37	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	134-140
18418053-0	2008	U-box-type ubiquitin E4 ligase, UFD2a attenuates cisplatin mediated degradation of DeltaNp63alpha.	deltanp63alpha	83-97	ubiquitination factor E4B	Homo sapiens	32-37
18418053-5	2008	UFD2a stabilizes DeltaNp63alpha, and ubiquitylation of DeltaNp63alpha is attenuated by UFD2a both in the presence and absence of cisplatin.	deltanp63alpha	17-31	ubiquitination factor E4B	Homo sapiens	0-5
18418053-5	2008	UFD2a stabilizes DeltaNp63alpha, and ubiquitylation of DeltaNp63alpha is attenuated by UFD2a both in the presence and absence of cisplatin.	deltanp63alpha	55-69	ubiquitination factor E4B	Homo sapiens	87-92
18326838-9	2008	In vitro, DeltaNp63alpha induces transcription from the Dlx5 and Dlx6 promoters, an activity abolished by EEC and SHFM-IV mutations, but not by Ankyloblepharon-Ectodermal defects-Cleft lip/palate (AEC) mutations.	deltanp63alpha	10-24	distal-less homeobox 5	Homo sapiens	56-60
18026135-3	2008	Here we show that loss of endogenous p73 expression in squamous cell carcinoma (SCC) cells and tumors was concomitant with preferential DNA binding of the inhibitory DeltaNp63alpha isoform and reduction of transcriptionally active p63gamma isoforms binding to a p21 promoter sequence in vitro.	deltanp63alpha	166-180	tumor protein p73	Homo sapiens	37-40
18326838-9	2008	In vitro, DeltaNp63alpha induces transcription from the Dlx5 and Dlx6 promoters, an activity abolished by EEC and SHFM-IV mutations, but not by Ankyloblepharon-Ectodermal defects-Cleft lip/palate (AEC) mutations.	deltanp63alpha	10-24	distal-less homeobox 6	Homo sapiens	65-69
17392828-6	2007	DeltaNp63alpha also induces apoptosis in HaCaT and SCC-13 cells, which encode inactive p53 genes, suggesting that the response is p53 independent in these cell lines.	deltanp63alpha	0-14	tumor protein p53	Homo sapiens	87-90
17392828-6	2007	DeltaNp63alpha also induces apoptosis in HaCaT and SCC-13 cells, which encode inactive p53 genes, suggesting that the response is p53 independent in these cell lines.	deltanp63alpha	0-14	tumor protein p53	Homo sapiens	130-133
15467455-5	2004	However, stratifin binds with phosphorylated DeltaNp63alpha in response to cisplatin.	deltanp63alpha	45-59	stratifin	Homo sapiens	9-18
17360634-5	2007	We propose that DeltaNp63alpha initially induces expression of the extracellular matrix component Fras1, which is required for maintaining the integrity of the epidermal-dermal interface at the basement membrane.	deltanp63alpha	16-30	Fraser extracellular matrix complex subunit 1	Mus musculus	98-103
17360634-6	2007	Subsequently, induction of IkappaB kinase-alpha by DeltaNp63alpha initiates epidermal terminal differentiation resulting in the formation of the spinous layer.	deltanp63alpha	51-65	conserved helix-loop-helix ubiquitous kinase	Mus musculus	27-47
16687923-4	2006	A recent study using RNA interference in human SCC-derived cell lines shows that DeltaNp63alpha mediates an essential survival function in human SCC cells by virtue of its ability to suppress the pro-apoptotic function of the related p53 family member p73.	deltanp63alpha	81-95	tumor protein p53	Homo sapiens	234-237
16687923-4	2006	A recent study using RNA interference in human SCC-derived cell lines shows that DeltaNp63alpha mediates an essential survival function in human SCC cells by virtue of its ability to suppress the pro-apoptotic function of the related p53 family member p73.	deltanp63alpha	81-95	tumor protein p73	Homo sapiens	252-255
16007154-3	2005	In proliferating keratinocytes, the activity of p53 is blunted by its inhibitor DeltaNp63alpha.	deltanp63alpha	80-94	tumor protein p53	Homo sapiens	48-51
12789272-8	2003	Maximal deltaNp63alpha-induced transactivation requires intact p53 responsive elements, but is independent of cellular p53 status.	deltanp63alpha	8-22	transformation related protein 53, pseudogene	Mus musculus	63-66
14647429-0	2004	Gadd45a regulates matrix metalloproteinases by suppressing DeltaNp63alpha and beta-catenin via p38 MAP kinase and APC complex activation.	deltanp63alpha	59-73	growth arrest and DNA-damage-inducible 45 alpha	Mus musculus	0-7
14647429-5	2004	DeltaNp63alpha also associates with and blocks activation of the adenomatous polyposis coli (APC) destruction complex that targets free cytoplasmic beta-catenin for degradation.	deltanp63alpha	0-14	catenin (cadherin associated protein), beta 1	Mus musculus	148-160
14647429-12	2004	These findings demonstrate a dependence on Gadd45a-mediated p38 MAPK and p53 activation for proper modulation of DeltaNp63alpha, GSK3beta, and beta-catenin after irradiation.	deltanp63alpha	113-127	growth arrest and DNA-damage-inducible 45 alpha	Mus musculus	43-50
14647429-12	2004	These findings demonstrate a dependence on Gadd45a-mediated p38 MAPK and p53 activation for proper modulation of DeltaNp63alpha, GSK3beta, and beta-catenin after irradiation.	deltanp63alpha	113-127	mitogen-activated protein kinase 14	Mus musculus	60-63
14647429-12	2004	These findings demonstrate a dependence on Gadd45a-mediated p38 MAPK and p53 activation for proper modulation of DeltaNp63alpha, GSK3beta, and beta-catenin after irradiation.	deltanp63alpha	113-127	transformation related protein 53	Mus musculus	73-76
14647429-13	2004	Taken together, our results indicate that Gadd45a is able to repress DeltaNp63alpha, beta-catenin, and consequently MMP expression by two means: by maintaining UVR-induced p38 MAPK and p53 activation and also by associating with the APC complex.	deltanp63alpha	69-83	growth arrest and DNA-damage-inducible 45 alpha	Mus musculus	42-49
32243883-8	2020	Furthermore, we demonstrated that PABPN1 deficiency inhibits cell growth, which can be rescued by ectopic DeltaNp63alpha.	deltanp63alpha	106-120	poly(A) binding protein nuclear 1	Homo sapiens	34-40
34816327-7	2022	Our findings clearly confirmed that the p. H1047R and p. H1047L mutants could reduce the inhibitory effect of DeltaNp63alpha on the kinase domain of PIK3CA, resulting in increased activity of PI3K downstream signals.	deltanp63alpha	110-124	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	149-155
31576015-8	2020	We also demonstrated that DeltaNp63alpha downregulated NFATC1 to reduce cisplatin resistance.	deltanp63alpha	26-40	nuclear factor of activated T cells 1	Homo sapiens	55-61
32528070-0	2020	DeltaNp63alpha-induced DUSP4/GSK3beta/SNAI1 pathway in epithelial cells drives endometrial fibrosis.	deltanp63alpha	0-14	dual specificity phosphatase 4	Homo sapiens	23-28
32528070-0	2020	DeltaNp63alpha-induced DUSP4/GSK3beta/SNAI1 pathway in epithelial cells drives endometrial fibrosis.	deltanp63alpha	0-14	glycogen synthase kinase 3 alpha	Homo sapiens	29-37
32528070-0	2020	DeltaNp63alpha-induced DUSP4/GSK3beta/SNAI1 pathway in epithelial cells drives endometrial fibrosis.	deltanp63alpha	0-14	snail family transcriptional repressor 1	Homo sapiens	38-43
31515469-0	2019	DeltaNp63alpha suppresses cells invasion by downregulating PKCgamma/Rac1 signaling through miR-320a.	deltanp63alpha	0-14	protein kinase C gamma	Homo sapiens	59-67
31515469-0	2019	DeltaNp63alpha suppresses cells invasion by downregulating PKCgamma/Rac1 signaling through miR-320a.	deltanp63alpha	0-14	Rac family small GTPase 1	Homo sapiens	68-72
31515469-0	2019	DeltaNp63alpha suppresses cells invasion by downregulating PKCgamma/Rac1 signaling through miR-320a.	deltanp63alpha	0-14	microRNA 320a	Homo sapiens	91-99
30635119-0	2019	DeltaNp63alpha modulates phosphorylation of p38 MAP kinase in regulation of cell cycle progression and cell growth.	deltanp63alpha	0-14	mitogen-activated protein kinase 14	Homo sapiens	44-58
30232004-0	2018	DeltaNp63alpha Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas.	deltanp63alpha	0-14	transforming growth factor beta 2	Homo sapiens	26-31
30232004-0	2018	DeltaNp63alpha Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas.	deltanp63alpha	0-14	ras homolog family member A	Homo sapiens	47-51
29782646-0	2018	Cullin3/KCTD5 induces monoubiquitination of DeltaNp63alpha and impairs its activity.	deltanp63alpha	44-58	cullin 3	Homo sapiens	0-7
29782646-0	2018	Cullin3/KCTD5 induces monoubiquitination of DeltaNp63alpha and impairs its activity.	deltanp63alpha	44-58	potassium channel tetramerization domain containing 5	Homo sapiens	8-13
29782646-3	2018	In our present study, we report that KCTD5 may physically interact with DeltaNp63alpha, which is a member of the p53 family.	deltanp63alpha	72-86	potassium channel tetramerization domain containing 5	Homo sapiens	37-42
29782646-3	2018	In our present study, we report that KCTD5 may physically interact with DeltaNp63alpha, which is a member of the p53 family.	deltanp63alpha	72-86	tumor protein p53	Homo sapiens	113-116
29782646-4	2018	Our further investigation revealed that Cullin3/KCTD5 can induce monoubiquitination of DeltaNp63alpha.	deltanp63alpha	87-101	cullin 3	Homo sapiens	40-47
29782646-4	2018	Our further investigation revealed that Cullin3/KCTD5 can induce monoubiquitination of DeltaNp63alpha.	deltanp63alpha	87-101	potassium channel tetramerization domain containing 5	Homo sapiens	48-53
29782646-5	2018	Cullin3/KCTD5 downregulates the DNA-binding affinity of DeltaNp63alpha, impairing either its transactivity or its transinhibitory activity.	deltanp63alpha	56-70	cullin 3	Homo sapiens	0-7
29782646-5	2018	Cullin3/KCTD5 downregulates the DNA-binding affinity of DeltaNp63alpha, impairing either its transactivity or its transinhibitory activity.	deltanp63alpha	56-70	potassium channel tetramerization domain containing 5	Homo sapiens	8-13