PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16322057-5	2006	We also provide direct evidence for the functional expression of v-Glut-2 in astrocytes and demonstrate that synaptobrevin2-positive vesicles can specifically take up (3H)L-glutamate via a bafilomycin-sensitive mechanism.	bafilomycin	189-200	solute carrier family 17 member 6	Rattus norvegicus	65-73
16322057-5	2006	We also provide direct evidence for the functional expression of v-Glut-2 in astrocytes and demonstrate that synaptobrevin2-positive vesicles can specifically take up (3H)L-glutamate via a bafilomycin-sensitive mechanism.	bafilomycin	189-200	vesicle-associated membrane protein 2	Rattus norvegicus	109-123
16144834-9	2005	The inhibitors of lysosome maturation, bafilomycin and chloroquine, inhibited the poly(I-C)-induced biological response in immune cells, showing that TLR3 interacted with its ligand in acidic subcellular compartments.	bafilomycin	39-50	toll like receptor 3	Homo sapiens	150-154
16475697-6	2006	In the in vitro study, bafilomycin A1 was exposed to LM 8 mouse osteosarcoma cells, in order to inhibit V-ATPase, subsequently causing a decrease in the pHgradient (deltapH) between the intracellular pH (pHi) and extracellular pH (pHe) or between the pHi and the pHe.	bafilomycin	23-34	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	104-112
16475697-6	2006	In the in vitro study, bafilomycin A1 was exposed to LM 8 mouse osteosarcoma cells, in order to inhibit V-ATPase, subsequently causing a decrease in the pHgradient (deltapH) between the intracellular pH (pHi) and extracellular pH (pHe) or between the pHi and the pHe.	bafilomycin	23-34	glucose-6-phosphate isomerase 1	Mus musculus	204-207
16475697-6	2006	In the in vitro study, bafilomycin A1 was exposed to LM 8 mouse osteosarcoma cells, in order to inhibit V-ATPase, subsequently causing a decrease in the pHgradient (deltapH) between the intracellular pH (pHi) and extracellular pH (pHe) or between the pHi and the pHe.	bafilomycin	23-34	glucose-6-phosphate isomerase 1	Mus musculus	251-254
16236270-3	2005	In this work, we have studied the effect of bafilomycin A1, a potent and specific inhibitor of vacuolar H(+)-pump (V-ATPase), on acrosome reaction and proacrosin activation.	bafilomycin	44-55	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	115-123
16236270-3	2005	In this work, we have studied the effect of bafilomycin A1, a potent and specific inhibitor of vacuolar H(+)-pump (V-ATPase), on acrosome reaction and proacrosin activation.	bafilomycin	44-55	acrosin	Homo sapiens	151-161
16182247-4	2005	Neither is it reduced by some inhibitors of lysosomal proteinases, proteasomes or zinc-metalloproteinases, but incubation with bafilomycin A1, an inhibitor of vacuolar H+/ATPases, increases the amount of uncleaved PrP in the apical medium of MDCK cells.	bafilomycin	127-138	prion protein	Canis lupus familiaris	214-217
15542860-3	2005	The effect of selective vacuolar H+-ATPase (V-ATPase) inhibitor bafilomycin A1 on the pH gradient along the secretory pathway was used here to study the role of acidification on the trafficking of the regulated secretory protein chromogranin A (CgA) in PC12 cells.	bafilomycin	64-75	chromogranin A	Rattus norvegicus	229-243
15714281-0	2005	Transferrin recycling and dextran transport to lysosomes is differentially affected by bafilomycin, nocodazole, and low temperature.	bafilomycin	87-98	transferrin	Homo sapiens	0-11
15714281-8	2005	Taken together, these data clearly demonstrate, for the first time, that the transferrin recycling pathway and transport of endocytosed material to lysosomes are differentially affected by bafilomycin, nocodazole, and low temperature in HeLa cells.	bafilomycin	189-200	transferrin	Homo sapiens	77-88
15797711-7	2005	This effect of CAP-1A is blocked by bafilomycin A1 treatment of transfected DRG neurons.	bafilomycin	36-47	sodium channel and clathrin linker 1	Homo sapiens	15-21
16113235-6	2005	Over-expression of hTJ6 in HEK 293 cells increased H+ uptake into intracellular organelles, an effect that was sensitive to inhibition by bafilomycin, a selective inhibitor of vacuolar H+ pump.	bafilomycin	138-149	ATPase H+ transporting V0 subunit a2	Homo sapiens	19-23
15542860-3	2005	The effect of selective vacuolar H+-ATPase (V-ATPase) inhibitor bafilomycin A1 on the pH gradient along the secretory pathway was used here to study the role of acidification on the trafficking of the regulated secretory protein chromogranin A (CgA) in PC12 cells.	bafilomycin	64-75	chromogranin A	Rattus norvegicus	245-248
15166000-3	2004	Here, we report that incubation of 3T3-L1 adipocytes with specific inhibitors of V-type ATPase, concanamycin A and bafilomycin A1, inhibits insulin-regulated glucose transport and results in accumulation of GLUT4 in heavy, rapidly sedimenting intracellular membranes.	bafilomycin	115-126	insulin	Homo sapiens	140-147
15607501-7	2004	In turn, blocking V-ATPase by injecting a V-ATPase blocker, bafilomycin, in M. domestica increased the axon sizes of L1 and L2, but only when bafilomycin was applied during the night.	bafilomycin	60-71	Vacuolar H[+]-ATPase 55kD subunit	Drosophila melanogaster	18-26
15607501-7	2004	In turn, blocking V-ATPase by injecting a V-ATPase blocker, bafilomycin, in M. domestica increased the axon sizes of L1 and L2, but only when bafilomycin was applied during the night.	bafilomycin	60-71	Vacuolar H[+]-ATPase 55kD subunit	Drosophila melanogaster	42-50
15607501-7	2004	In turn, blocking V-ATPase by injecting a V-ATPase blocker, bafilomycin, in M. domestica increased the axon sizes of L1 and L2, but only when bafilomycin was applied during the night.	bafilomycin	142-153	Vacuolar H[+]-ATPase 55kD subunit	Drosophila melanogaster	18-26
15607501-7	2004	In turn, blocking V-ATPase by injecting a V-ATPase blocker, bafilomycin, in M. domestica increased the axon sizes of L1 and L2, but only when bafilomycin was applied during the night.	bafilomycin	142-153	Vacuolar H[+]-ATPase 55kD subunit	Drosophila melanogaster	42-50
15166000-3	2004	Here, we report that incubation of 3T3-L1 adipocytes with specific inhibitors of V-type ATPase, concanamycin A and bafilomycin A1, inhibits insulin-regulated glucose transport and results in accumulation of GLUT4 in heavy, rapidly sedimenting intracellular membranes.	bafilomycin	115-126	solute carrier family 2 member 4	Homo sapiens	207-212
14713959-9	2004	On the other hand, bafilomycin A1, a specific inhibitor of vacuolar type H(+)-ATPase, that prevents autophagy at a late stage by inhibiting fusion between autophagosomes and lysosomes, sensitized tumor cells to TMZ by inducing apoptosis through activation of caspase-3 with mitochondrial and lysosomal membrane permeabilization, while LC3 localization pattern stayed the same.	bafilomycin	19-30	caspase 3	Homo sapiens	259-268
15148249-2	2004	Studies of bafilomycin derivatives suggest that the key issue regarding the therapeutic usefulness of V-ATPase inhibitors is selective inhibition of osteoclast V-ATPase.	bafilomycin	11-22	dynein axonemal heavy chain 8	Homo sapiens	102-110
15148249-2	2004	Studies of bafilomycin derivatives suggest that the key issue regarding the therapeutic usefulness of V-ATPase inhibitors is selective inhibition of osteoclast V-ATPase.	bafilomycin	11-22	dynein axonemal heavy chain 8	Homo sapiens	160-168
14752118-12	2004	A taurocholate influx assay and membrane biotinylation analysis showed that treatment with bafilomycin A1 resulted in a significant decrease in bile acid transport activity and the apical membrane localization of Asbt in transfected cells.	bafilomycin	91-102	solute carrier family 10 member 2	Rattus norvegicus	213-217
14713959-9	2004	On the other hand, bafilomycin A1, a specific inhibitor of vacuolar type H(+)-ATPase, that prevents autophagy at a late stage by inhibiting fusion between autophagosomes and lysosomes, sensitized tumor cells to TMZ by inducing apoptosis through activation of caspase-3 with mitochondrial and lysosomal membrane permeabilization, while LC3 localization pattern stayed the same.	bafilomycin	19-30	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	335-338
12023333-5	2002	Increasing the pH of acidic compartments by incubating cells with chloroquine or bafilomycin A1 blocked CD1d1 recognition by Valpha14(+) (but not Valpha14(-)) NKT cells without reducing levels of cell surface CD1d1.	bafilomycin	81-92	CD1d1 antigen	Mus musculus	104-109
12647307-7	2003	Osteoclasts treated with Bafilomycin A1 exhibited apoptosis as well as altered cellular localization of Transferrin Alexa 647.	bafilomycin	25-36	transferrin	Homo sapiens	104-115
12477806-6	2003	Finally, incubation of antigen-presenting cells with SIV Gag p55 immune complexes in the presence of lactacystin or of bafilomycin indicated that the mechanism of antibody-mediated enhancement of cross presentation required both the proteasomal and the endosomal pathways.	bafilomycin	119-130	H3 histone pseudogene 44	Homo sapiens	61-64
12829707-7	2003	Furthermore, bafilomycin treatment blocks EGFR but not c-Cbl degradation.	bafilomycin	13-24	epidermal growth factor receptor	Mus musculus	42-46
12829707-10	2003	Strikingly, when combined with bafilomycin, lactacystin treatment stabilizes the ubiquitinated EGFR and prevents its de-ubiquitination.	bafilomycin	31-42	epidermal growth factor receptor	Mus musculus	95-99
12935787-5	2003	In particular, we studied the effects of the proteasome inhibitor lactacystin and the endosomal acidification inhibitor bafilomycin on the induction of PDC-E2-specific CTL response in PBC.	bafilomycin	120-131	dihydrolipoamide S-acetyltransferase	Homo sapiens	152-158
12935787-6	2003	Importantly, our data indicate that pre-treatment with either lactacystin or bafilomycin inhibits the PDC-E2 immune complex-induced CTL response.	bafilomycin	77-88	dihydrolipoamide S-acetyltransferase	Homo sapiens	102-108
12647307-3	2003	Quantitative analysis by flow cytometry showed that Bafilomycin A1 increased total transferrin levels when RAW cells were exposed to labeled transferrin and decreased the total uptake of Dextran-rhodamine B, both in a dose- and time-dependent fashion, indicating that Bafilomycin influences receptor-mediated and fluid phase endocytosis in these cells.	bafilomycin	52-63	transferrin	Homo sapiens	83-94
12647307-3	2003	Quantitative analysis by flow cytometry showed that Bafilomycin A1 increased total transferrin levels when RAW cells were exposed to labeled transferrin and decreased the total uptake of Dextran-rhodamine B, both in a dose- and time-dependent fashion, indicating that Bafilomycin influences receptor-mediated and fluid phase endocytosis in these cells.	bafilomycin	52-63	transferrin	Homo sapiens	141-152
12647307-4	2003	Furthermore, Bafilomycin A1 induced apoptosis of RAW cells in a dose dependent manner as evidenced by Annexin V flow cytometry.	bafilomycin	13-24	annexin A5	Homo sapiens	102-111
12675272-7	2003	Bafilomycin A1 had biphasic effects on baseline pHi at pHo 6.5-7.4; pHi declined approximately 0.1 units over the course of several minutes and then recovered.	bafilomycin	0-11	glucose-6-phosphate isomerase	Homo sapiens	48-51
12763066-9	2003	muOR recycling was prevented by pre-treatment with bafilomycin A1, an acidotropic agent that inhibits endosomal acidification, but not by the protein synthesis inhibitor, cycloheximide.	bafilomycin	51-62	mu-type opioid receptor	Cavia porcellus	0-4
12133827-11	2002	Furthermore, combination of the vacuolar H(+)-ATPase (V-ATPase) inhibitor, bafilomycin A1, with TAS-103 enhanced apoptosis of KB cells with an associated increase in caspase-3 activity.	bafilomycin	75-86	caspase 3	Homo sapiens	166-175
12023333-5	2002	Increasing the pH of acidic compartments by incubating cells with chloroquine or bafilomycin A1 blocked CD1d1 recognition by Valpha14(+) (but not Valpha14(-)) NKT cells without reducing levels of cell surface CD1d1.	bafilomycin	81-92	T cell receptor alpha, variable 14	Mus musculus	125-133
12023333-5	2002	Increasing the pH of acidic compartments by incubating cells with chloroquine or bafilomycin A1 blocked CD1d1 recognition by Valpha14(+) (but not Valpha14(-)) NKT cells without reducing levels of cell surface CD1d1.	bafilomycin	81-92	CD1d1 antigen	Mus musculus	209-214
11449359-13	2001	The extent of Nramp1-dependent iron-release was influenced by bafilomycin A1, and endogenous nitric oxide synthesis, both inhibitors of vacuolar-ATPase.	bafilomycin	62-73	solute carrier family 11 member 1	Homo sapiens	14-20
11815462-5	2002	The latter reaction depends on intragranular acidification due to the concerted action of granular bafilomycin-sensitive v-type H(+)-ATPase and 4,4-diisothiocyanostilbene-2,2-disulfonate--blockable ClC-3 Cl(-) channels.	bafilomycin	99-110	chloride channel, voltage-sensitive 3	Mus musculus	198-203
11818410-8	2002	Bafilomycin, a selective inhibitor of V-ATPase activity, also prevents the decline in luminal pH.	bafilomycin	0-11	V-type proton ATPase subunit c2	Gossypium hirsutum	38-46
11784768-4	2002	Application of tetrodotoxin or incubation of slices with bafilomycin A1 had no effect on astrocytic calcium oscillations but did block evoked and spontaneous postsynaptic currents measured in CA1 pyramidal neurons.	bafilomycin	57-68	carbonic anhydrase 1	Homo sapiens	192-195
11925914-5	2002	Glucocorticoid and bafilomycin inhibited RV infection in the epithelial cells by reducing ICAM-1 expression and RV RNA entry from the acidic endosomes to the cytoplasm.	bafilomycin	19-30	intercellular adhesion molecule 1	Homo sapiens	90-96
11701755-6	2001	Both tetanus toxin and bafilomycin abolished the depolarization-evoked glutamate release with or without BDNF, indicating that BDNF acted via an exocytotic pathway.	bafilomycin	23-34	brain derived neurotrophic factor	Homo sapiens	105-109
11701755-6	2001	Both tetanus toxin and bafilomycin abolished the depolarization-evoked glutamate release with or without BDNF, indicating that BDNF acted via an exocytotic pathway.	bafilomycin	23-34	brain derived neurotrophic factor	Homo sapiens	127-131
11737651-4	2001	Disruption of VPH1 resulted in defects in three virulence factors (capsule production, laccase and urease expression), as well as a growth defect at 37 degrees C, but only a small growth reduction at 30 degrees C. These effects were duplicated by the vacuolar (H+)-ATPase inhibitor bafilomycin A1.	bafilomycin	282-293	T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	Mus musculus	14-18
11519050-7	2001	Furthermore, the proton pump inhibitor bafilomycin can synergistically potentiate the cytotoxicity of cisplatin but not of etoposide or camptothecin.	bafilomycin	39-50	ATPase H+/K+ transporting non-gastric alpha2 subunit	Homo sapiens	17-28
11139343-7	2001	Inhibition of the vacuolar proton pump V-ATPase by treatment of Caucasian melanocytes with bafilomycin also increases tyrosinase activity.	bafilomycin	91-102	tyrosinase	Homo sapiens	118-128
11425799-7	2001	Bafilomycin (0.01 microM; 48 h) reduced total mucin sulfation, expressed relative to incorporation of glucosamine, to 0.50 +/- 0.04 d.p.m.	bafilomycin	0-11	LOC100508689	Homo sapiens	46-51
11717580-7	2001	Surprisingly, while degradation of HIV-1 p24 in LPS-treated cells was inhibited by bafilomycin A1, HIV-1 RNA was not protected by this agent, suggesting that viral RNA is degraded by a pH-independent mechanism.	bafilomycin	83-94	transmembrane p24 trafficking protein 2	Homo sapiens	41-44
10444585-9	1999	Addition of 1 microM bafilomycin caused a similar absolute decrement in J(HCO3) in wild-type and NHE3 null mice, indicating equivalent rates of HCO(-)(3) absorption mediated by H(+)-ATPase.	bafilomycin	21-32	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	97-101
10662736-0	2000	Recycling of AQP2 occurs through a temperature- and bafilomycin-sensitive trans-Golgi-associated compartment.	bafilomycin	52-63	aquaporin 2	Homo sapiens	13-17
10662736-6	2000	Colocalization of AQP2 with clathrin, but not with giantin, after both bafilomycin treatment and a 20 degrees C block suggests that the compartment in which recycling AQP2 is blocked may be the trans-Golgi, and not cis- and medial-Golgi cisternae.	bafilomycin	71-82	aquaporin 2	Homo sapiens	18-22
10639743-11	1999	Immunoreactivity for the vacuolar type of proton ATPase (V-ATPase) was demonstrable in the cytoplasm of the osteoclasts but was weakened by the addition of bafilomycin.	bafilomycin	156-167	dynein axonemal heavy chain 8	Homo sapiens	49-55
10639743-11	1999	Immunoreactivity for the vacuolar type of proton ATPase (V-ATPase) was demonstrable in the cytoplasm of the osteoclasts but was weakened by the addition of bafilomycin.	bafilomycin	156-167	dynein axonemal heavy chain 8	Homo sapiens	57-65
10639743-13	1999	Besides, both bafilomycin and acetazolamide reversibly inhibited cellular acidity as judged by DAMP immunocytochemistry, which agrees with the fact that ostoeclastic acidification results from the action of vacuolar proton-pump ATPase coupled with carbonic anhydrase.	bafilomycin	14-25	dynein axonemal heavy chain 8	Homo sapiens	228-234
9988481-7	1998	Immunofluorescence localization revealed that YopM, in contrast to YopE, is not only targeted to the cytoplasm but also trafficks to the cell"s nucleus by means of a vesicle-associated pathway that is strongly inhibited by brefeldin A, perturbed by monensin or bafilomycin A1 and dependent upon microtubules (decreased by colchicine and nocodazole).	bafilomycin	261-272	outer membrane protein YopM	Yersinia pestis	46-50
10402472-5	1999	The reformation of cell junctions after replacement of Ca2+ was then found to be inhibited when recycling of endocytosed E-cadherin was disrupted by bafilomycin treatment.	bafilomycin	149-160	cadherin 1	Homo sapiens	121-131
10402472-6	1999	The endocytosis and recycling of E-cadherin and of the transferrin receptor were similarly inhibited by potassium depletion and by bafilomycin treatment, and both proteins were accumulated in intracellular compartments by an 18 degrees C temperature block, suggesting that endocytosis may occur via a clathrin-mediated pathway.	bafilomycin	131-142	cadherin 1	Homo sapiens	33-43
10215598-3	1999	We show here that arrest of endosome acidification in insulin-sensitive 3T3-L1 adipocytes by bafilomycin A1, a specific inhibitor of the vacuolar proton pump, results in the rapid and dose-dependent translocation of GLUT4 from the cell interior to the membrane surface; the effects of maximally stimulatory concentrations of bafilomycin A1 (400-800 nM) were equivalent to 50-65% of the effects of acute insulin treatment.	bafilomycin	93-104	insulin	Homo sapiens	54-61
10215598-3	1999	We show here that arrest of endosome acidification in insulin-sensitive 3T3-L1 adipocytes by bafilomycin A1, a specific inhibitor of the vacuolar proton pump, results in the rapid and dose-dependent translocation of GLUT4 from the cell interior to the membrane surface; the effects of maximally stimulatory concentrations of bafilomycin A1 (400-800 nM) were equivalent to 50-65% of the effects of acute insulin treatment.	bafilomycin	93-104	solute carrier family 2 member 4	Homo sapiens	216-221
10215598-3	1999	We show here that arrest of endosome acidification in insulin-sensitive 3T3-L1 adipocytes by bafilomycin A1, a specific inhibitor of the vacuolar proton pump, results in the rapid and dose-dependent translocation of GLUT4 from the cell interior to the membrane surface; the effects of maximally stimulatory concentrations of bafilomycin A1 (400-800 nM) were equivalent to 50-65% of the effects of acute insulin treatment.	bafilomycin	93-104	insulin	Homo sapiens	403-410
10215598-3	1999	We show here that arrest of endosome acidification in insulin-sensitive 3T3-L1 adipocytes by bafilomycin A1, a specific inhibitor of the vacuolar proton pump, results in the rapid and dose-dependent translocation of GLUT4 from the cell interior to the membrane surface; the effects of maximally stimulatory concentrations of bafilomycin A1 (400-800 nM) were equivalent to 50-65% of the effects of acute insulin treatment.	bafilomycin	325-336	insulin	Homo sapiens	54-61
10215598-3	1999	We show here that arrest of endosome acidification in insulin-sensitive 3T3-L1 adipocytes by bafilomycin A1, a specific inhibitor of the vacuolar proton pump, results in the rapid and dose-dependent translocation of GLUT4 from the cell interior to the membrane surface; the effects of maximally stimulatory concentrations of bafilomycin A1 (400-800 nM) were equivalent to 50-65% of the effects of acute insulin treatment.	bafilomycin	325-336	solute carrier family 2 member 4	Homo sapiens	216-221
10215598-6	1999	Bafilomycin-induced GLUT4 translocation was not blocked by cell pretreatment with wortmannin.	bafilomycin	0-11	solute carrier family 2 member 4	Homo sapiens	20-25
10098849-5	1999	Bafilomycin A1, which had no effect on beta-amyloid production in wild-type cells, inhibited endocytosis of fluorescent transferrin, whereas concentrations of FCCP that inhibited beta-amyloid production in these cells had no effect on endosomal function.	bafilomycin	0-11	transferrin	Homo sapiens	120-131
9502788-6	1998	The bafilomycin A1-induced increase in p53 protein levels was accompanied by a marked increase in p53 mRNA accumulation.	bafilomycin	4-15	tumor protein p53	Homo sapiens	39-42
9705342-6	1998	The inhibition of endosomal IRK tyrosine phosphorylation and activity was completely reversed by bafilomycin A1, indicating a role for endosomal proton pump(s).	bafilomycin	97-108	potassium inwardly rectifying channel subfamily J member 12	Homo sapiens	28-31
9716460-6	1998	When surface-bound TGFalpha was removed by acid stripping and endosomal pH was neutralized with bafilomycin A1, TGFalpha stimulated EGFR tyrosine phosphorylation, induced p21/CIP1, and inhibited DNA synthesis.	bafilomycin	96-107	transforming growth factor alpha	Homo sapiens	19-27
9716460-6	1998	When surface-bound TGFalpha was removed by acid stripping and endosomal pH was neutralized with bafilomycin A1, TGFalpha stimulated EGFR tyrosine phosphorylation, induced p21/CIP1, and inhibited DNA synthesis.	bafilomycin	96-107	transforming growth factor alpha	Homo sapiens	112-120
9716460-6	1998	When surface-bound TGFalpha was removed by acid stripping and endosomal pH was neutralized with bafilomycin A1, TGFalpha stimulated EGFR tyrosine phosphorylation, induced p21/CIP1, and inhibited DNA synthesis.	bafilomycin	96-107	epidermal growth factor receptor	Homo sapiens	132-136
9716460-6	1998	When surface-bound TGFalpha was removed by acid stripping and endosomal pH was neutralized with bafilomycin A1, TGFalpha stimulated EGFR tyrosine phosphorylation, induced p21/CIP1, and inhibited DNA synthesis.	bafilomycin	96-107	cyclin dependent kinase inhibitor 1A	Homo sapiens	171-174
9716460-6	1998	When surface-bound TGFalpha was removed by acid stripping and endosomal pH was neutralized with bafilomycin A1, TGFalpha stimulated EGFR tyrosine phosphorylation, induced p21/CIP1, and inhibited DNA synthesis.	bafilomycin	96-107	cyclin dependent kinase inhibitor 1A	Homo sapiens	175-179
9689138-8	1998	The AII-stimulated pH recovery was completely abolished by bafilomycin A1, by removal of Cl-, by NPPB [5-nitro-2-(3-phenylpropylamino)-benzoate; a potent Cl- channel blocker], and by colchicine.	bafilomycin	59-70	angiotensinogen	Rattus norvegicus	4-7
9749941-9	1998	Since weak bases and ionophores alter the morphology of vacuolar compartments, the effect of bafilomycin A1 on tropoelastin secretion was also investigated.	bafilomycin	93-104	elastin	Bos taurus	111-123
9657902-5	1998	Similarly, selective inhibition of V-type H+-ATPase with 10 microM bafilomycin A1 decreased pHi by 0.22 units.	bafilomycin	67-78	glucose-6-phosphate isomerase	Bos taurus	92-95
9500296-8	1998	The effects of bafilomycin specifically on TNF-alpha release followed a time course similar to that of acidic pHo, suggesting that both treatments acted on similar events in the lipopolysaccharide signal transduction pathway.	bafilomycin	15-26	tumor necrosis factor	Oryctolagus cuniculus	43-52
9502788-6	1998	The bafilomycin A1-induced increase in p53 protein levels was accompanied by a marked increase in p53 mRNA accumulation.	bafilomycin	4-15	tumor protein p53	Homo sapiens	98-101
9374657-10	1997	Bafilomycin A1 slowed the pHi increase after an NH4Cl (10 mM) prepulse.	bafilomycin	0-11	glucose-6-phosphate isomerase	Oryctolagus cuniculus	26-29
7536807-5	1995	A prolonged release of glutamate is also observed that is predominantly Ca2+ dependent for the first 6-10 min after the evoked increase in [Ca2+]c. This release is four times as large as that observed with 50 mM KCl and is predominantly exocytotic because release was inhibited by tetanus toxin, the V-type ATPase inhibitor bafilomycin, and Aga-Gl.	bafilomycin	324-335	carbonic anhydrase 2	Homo sapiens	72-75
9321906-7	1997	However, when Na+/H+ exchange was inhibited with EIPA, both bafilomycin A1 sensitive and potassium dependent, Sch-28080-sensitive components of pHi recovery were present.	bafilomycin	60-71	glucose-6-phosphate isomerase	Oryctolagus cuniculus	144-147
9236211-6	1997	Though NO3- is known to inhibit vacuolar-type (V) H+-ATPases, this effect was not responsible for the acidification since it persisted in the presence of the potent V-ATPase inhibitor bafilomycin A1.	bafilomycin	184-195	NBL1, DAN family BMP antagonist	Homo sapiens	7-10
9153255-1	1997	Treatment of Chinese hamster ovary cells with the vacuolar proton pump inhibitor bafilomycin A1 causes a 2-fold retardation in the rate of recycling of transfected human transferrin receptors back to the cell surface as measured using biochemical assays (Johnson, L. S. , Dunn, K. W., Pytowski, B., and McGraw, T. E. (1993) Mol.	bafilomycin	81-92	transferrin	Homo sapiens	170-181
9153255-6	1997	However, the rate constant for exit of transferrin receptors from recycling endosomes (ke) is reduced from 0.063 min-1 in untreated cells to 0.034 min-1 in the presence of bafilomycin A1.	bafilomycin	172-183	transferrin	Homo sapiens	39-50
8641177-7	1996	Competitive [125I]IGF-I binding and affinity cross-linking experiments suggested structure/function changes in cell-bound IGFBP-3 that were altered in the presence of chloroquine and bafilomycin.	bafilomycin	183-194	IGFI	Bos taurus	18-23
8641177-7	1996	Competitive [125I]IGF-I binding and affinity cross-linking experiments suggested structure/function changes in cell-bound IGFBP-3 that were altered in the presence of chloroquine and bafilomycin.	bafilomycin	183-194	insulin like growth factor binding protein 3	Bos taurus	122-129
7556439-6	1995	We have also determined that reagents disturbing pH of distinct endocytic compartments (chloroquine and bafilomycin A1, but not ammonium chloride) arrest recycling of the EBP and, at the same time, strongly inhibit deposition of insoluble elastin in cultures of sheep Ao SMC and in organ cultures of chicken aorta.	bafilomycin	104-115	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Ovis aries	171-174
7556439-6	1995	We have also determined that reagents disturbing pH of distinct endocytic compartments (chloroquine and bafilomycin A1, but not ammonium chloride) arrest recycling of the EBP and, at the same time, strongly inhibit deposition of insoluble elastin in cultures of sheep Ao SMC and in organ cultures of chicken aorta.	bafilomycin	104-115	elastin	Ovis aries	239-246
7593238-6	1995	Formyl-Met-Leu-Phe (fMLP) was found to stimulate V-pumps, as assessed by the appearance of bafilomycin-sensitive H+ extrusion.	bafilomycin	91-102	formyl peptide receptor 1	Homo sapiens	0-18
7593238-6	1995	Formyl-Met-Leu-Phe (fMLP) was found to stimulate V-pumps, as assessed by the appearance of bafilomycin-sensitive H+ extrusion.	bafilomycin	91-102	formyl peptide receptor 1	Homo sapiens	20-24
7722418-4	1995	PMA-induced changes in pHi were sensitive to bafilomycin A1, but were insensitive to amiloride.	bafilomycin	45-56	glucose-6-phosphate isomerase	Oryctolagus cuniculus	23-26
7563029-10	1995	10(-7) M Bafilomycin, which reduced by 56 +/- 9% the ATPase activity in dog kidney brush border membranes treated with 0.1% DOC, had no effect on placental brush border membranes subjected to the same procedure.	bafilomycin	9-20	dynein axonemal heavy chain 8	Homo sapiens	53-59
8373164-3	1993	The uptake was sensitive to reserpine (1 microM) and bafilomycin (50 nM) (inhibitors of the vesicular monoamine transporter and vacuolar-type H(+)-ATPase, respectively) and substrates for monoamine transporters, but insensitive to imipramine (an inhibitor of the monoamine transporter present in the plasma membrane).	bafilomycin	53-64	solute carrier family 18 member A2	Homo sapiens	102-123
7852298-0	1995	Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases.	bafilomycin	86-97	amyloid beta precursor protein	Homo sapiens	68-74
7937155-9	1994	Acidification of F-PS oligos could be blocked by the antibiotic bafilomycin, indicating that acidification was occurring in endosomes or vacuoles.	bafilomycin	64-75	farnesyl diphosphate synthase	Homo sapiens	17-21
7864640-5	1995	In chondrocyte monolayers, bafilomycin A1 could be added several hours after IL-1 and complete inhibition was still observed.	bafilomycin	27-38	interleukin 1 alpha	Homo sapiens	77-81
7852842-3	1995	Bafilomycin caused a significant cytosolic acidification in both the absence and presence of CO2-HCO3-, and in both unstimulated and activated m phi.	bafilomycin	0-11	glucose-6-phosphate isomerase	Oryctolagus cuniculus	145-148
7852842-4	1995	Superoxide production and Fc receptor-mediated phagocytosis also were reduced in bafilomycin-treated m phi.	bafilomycin	81-92	glucose-6-phosphate isomerase	Oryctolagus cuniculus	103-106
7852842-7	1995	Conversely, bafilomycin significantly increased TNF-alpha release.	bafilomycin	12-23	tumor necrosis factor	Oryctolagus cuniculus	48-57
9117439-1	1995	Secretion of N-acetyl-beta-D-glucosaminidase (NAG) in response to zymosan particles, lysosomotropic methylamine, or the H(+)-ATPase inhibitor bafilomycin A1 was inhibited by pretreatment with dex.	bafilomycin	142-153	O-GlcNAcase	Mus musculus	13-44
9117439-1	1995	Secretion of N-acetyl-beta-D-glucosaminidase (NAG) in response to zymosan particles, lysosomotropic methylamine, or the H(+)-ATPase inhibitor bafilomycin A1 was inhibited by pretreatment with dex.	bafilomycin	142-153	O-GlcNAcase	Mus musculus	46-49
7943238-4	1994	However, 6 min after superfusion with a solution containing zero Na+, 1 x 10(5) M Sch-28080 and 5 x 10(-8) M bafilomycin A1, pHi in cells at the bottom of the crypts was significantly reduced, whereas pHi in cells at the top of the crypts remained unchanged.	bafilomycin	109-120	glucose-6-phosphate isomerase	Oryctolagus cuniculus	125-128
8253856-6	1993	At pHo 6.7, maintenance of pHi depends primarily on H+ ATPase activity: bafilomycin A1 reduced pHi from 6.8 +/- 0.02 in control cells to 6.59 +/- 0.01 (P < 0.01) while EPA was without effect.	bafilomycin	72-83	glucose-6-phosphate isomerase 1	Mus musculus	27-30
8253856-6	1993	At pHo 6.7, maintenance of pHi depends primarily on H+ ATPase activity: bafilomycin A1 reduced pHi from 6.8 +/- 0.02 in control cells to 6.59 +/- 0.01 (P < 0.01) while EPA was without effect.	bafilomycin	72-83	glucose-6-phosphate isomerase 1	Mus musculus	95-98
8253856-7	1993	The functional importance of V-type H+ ATPase-activity in preserving pHi homeostasis at acidic extracellular pH levels was reflected by the impairment of O2- production at pHo 6.70 when H+ ATPase activity was inhibited: bafilomycin A1 reduced O2- production from 13.9 +/- 1.0 to 9.3 +/- 0.6 nmoles/10(6) cells/40 min, in control and bafilomycin A1-treated cells, respectively (P < 0.05), while EPA had no effect.	bafilomycin	220-231	glucose-6-phosphate isomerase 1	Mus musculus	69-72
8238296-5	1993	Bafilomycin A1 decreased pHi in the six tumor cell lines with the highest resting pHi in the absence of HCO3-.	bafilomycin	0-11	glucose-6-phosphate isomerase	Homo sapiens	25-28
8238296-5	1993	Bafilomycin A1 decreased pHi in the six tumor cell lines with the highest resting pHi in the absence of HCO3-.	bafilomycin	0-11	glucose-6-phosphate isomerase	Homo sapiens	82-85
8373164-3	1993	The uptake was sensitive to reserpine (1 microM) and bafilomycin (50 nM) (inhibitors of the vesicular monoamine transporter and vacuolar-type H(+)-ATPase, respectively) and substrates for monoamine transporters, but insensitive to imipramine (an inhibitor of the monoamine transporter present in the plasma membrane).	bafilomycin	53-64	solute carrier family 18 member A2	Homo sapiens	188-209
8344379-7	1993	Bafilomycin A1, which inhibits V-ATPase and stops vacuolar acidification, does not affect dye coupling, showing that the inhibition seen with antibodies and DCCD is not an indirect consequence of their action on the ductin of V-ATPase.	bafilomycin	0-11	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	31-39
8388649-10	1993	Addition of H(+)-ATPase inhibitors, NBD-Cl or bafilomycin, following PMA stimulation or acid loading, inhibited pHi restoration.	bafilomycin	46-57	glucose-6-phosphate isomerase	Rattus norvegicus	112-115
1314493-4	1992	In addition, amiloride-insensitive pHi recovery was inhibited by bafilomycin A1, 10(-3) M N-ethylmaleimide, and 10(-4) M preactivated omeprazole but not by 10(-5) M vanadate, 10(-4) M SCH 28080, or removal of extracellular potassium.	bafilomycin	65-76	glucose-6-phosphate isomerase	Rattus norvegicus	35-38
8381601-3	1993	A bafilomycin-insensitive recovery of pHi of 0.05 +/- 0.02 pH units occurred, but pHi did not exceed electrochemical equilibrium.	bafilomycin	2-13	glucose-6-phosphate isomerase	Oryctolagus cuniculus	38-41
33940186-12	2021	FBXL5 was correlated significantly with austocystin d and bafilomycin and played an important role in anti-tumor and immunotherapy.	bafilomycin	58-69	F-box and leucine rich repeat protein 5	Homo sapiens	0-5
1660409-1	1991	Bafilomycin A1, a selective inhibitor of vacuolar H(+)-ATPase, induced neurite outgrowth of PC12 cells dose- and time-dependently: more than 50% of the cells extended neurite-like spikes after 24 h treatment with 100 nM bafilomycin A1.	bafilomycin	0-11	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	12-61
1831509-5	1991	The results showed that bafilomycin A1 induced a major increase in drug accumulation and inhibited drug efflux in both HL60/Adr cells and HL60/Vinc cells.	bafilomycin	24-35	nuclear paraspeckle assembly transcript 1	Homo sapiens	143-147
1859366-4	1991	Moreover, the LPS-enhanced GTPase activity was not antagonized by phosphatase/ATPase inhibitors such as p-nitrophenyl phosphate, ouabain, bafilomycin or N-ethylmaleimide, and in fact was potentiated by the addition of ATP or ADP.	bafilomycin	138-149	toll-like receptor 4	Mus musculus	14-17
2149857-6	1990	Both ATP-dependent H+ pump activity and L-glutamate uptake were inhibited by bafilomycin and cold treatment (common properties of vacuolar H(+)-ATPase).	bafilomycin	77-88	ATPase H+ transporting V1 subunit B2	Bos taurus	130-150
1317456-4	1992	Readdition of Na+ in the presence of bafilomycin A1 produced an immediate recovery of pHi by a mechanism sensitive to the addition of 10 microM EIPA (ethylisopropylamiloride), a specific inhibitor of Na+/H+ exchange.	bafilomycin	37-48	glucose-6-phosphate isomerase	Rattus norvegicus	86-89
2069575-1	1991	Effects of bafilomycin A1, an inhibitor of vacuolar H(+)-ATPase, on the synthesis and processing of cathepsin D and cathepsin H were investigated in primary cultured rat hepatocytes.	bafilomycin	11-22	cathepsin D	Rattus norvegicus	100-111
35387234-8	2022	However, monensin, a chemical mimetic of Na+/H+ exchanger activity, and the H+ pump inhibitor bafilomycin bypassed NHE9 to directly alkalinize the endosomal lumen resulting in stabilization of RTKs and induction of Oct4 and Nanog.	bafilomycin	94-105	solute carrier family 9 member A9	Homo sapiens	115-119
34848256-8	2021	In Lamp2-knock down cells, pathologic alpha-synuclein was increased 12 h after DQ treatment, but there was no change observed at 24 h. In DQ-treated cells, macroautophagy by 3-methyladenine and bafilomycin inhibition increased Lamp2A expression, indicating an increase in CMA activity.	bafilomycin	194-205	synuclein alpha	Homo sapiens	38-53
34884763-9	2021	The lysosomal activity inhibitor bafilomycin A1 restored Glut4, IRAP, Syntaxin-6, and TBC1D4 content to those found in control adipocytes.	bafilomycin	33-44	solute carrier family 2 member 4	Homo sapiens	57-62
34884763-9	2021	The lysosomal activity inhibitor bafilomycin A1 restored Glut4, IRAP, Syntaxin-6, and TBC1D4 content to those found in control adipocytes.	bafilomycin	33-44	leucyl and cystinyl aminopeptidase	Homo sapiens	64-68
34884763-9	2021	The lysosomal activity inhibitor bafilomycin A1 restored Glut4, IRAP, Syntaxin-6, and TBC1D4 content to those found in control adipocytes.	bafilomycin	33-44	syntaxin 6	Homo sapiens	70-80
34884763-9	2021	The lysosomal activity inhibitor bafilomycin A1 restored Glut4, IRAP, Syntaxin-6, and TBC1D4 content to those found in control adipocytes.	bafilomycin	33-44	TBC1 domain family member 4	Homo sapiens	86-92
35572519-12	2022	The inhibitory effect of FGF21 on IL-1beta secretion was blunted with bafilomycin treatment, which blocked autophagy flux.	bafilomycin	70-81	fibroblast growth factor 21	Homo sapiens	25-30
35572519-12	2022	The inhibitory effect of FGF21 on IL-1beta secretion was blunted with bafilomycin treatment, which blocked autophagy flux.	bafilomycin	70-81	interleukin 1 alpha	Homo sapiens	34-42
34248643-6	2021	The anti-NLRP3 activity of IIIM-941 was significantly reversed when we attempted to block autophagy by using either pharmacological inhibitor bafilomycin A1or by using siRNA against AMPK.	bafilomycin	142-153	NLR family, pyrin domain containing 3	Mus musculus	9-14
35398304-7	2022	Specifically, the exosome fractions from the bafilomycin plus DFP-treated cells contained more mitochondrial DNA (mtDNA), mtDNA-derived mRNA transcripts, and citrate synthase protein.	bafilomycin	45-56	citrate synthase	Homo sapiens	158-174
35189139-7	2022	Furthermore, block of autophagy by Bafilomycin A1 (Baf A1) increases B7H3 levels and attenuates CD8+ T cell activation, while promotion of autophagy by V9302, a small molecule inhibitor of glutamine metabolism, decreases B7H3 expression and enhances Granzyme B (GzB) production of CD8+ T cells via regulation of reactive oxygen species (ROS) accumulation.	bafilomycin	35-46	CD276 antigen	Mus musculus	69-73
35387234-8	2022	However, monensin, a chemical mimetic of Na+/H+ exchanger activity, and the H+ pump inhibitor bafilomycin bypassed NHE9 to directly alkalinize the endosomal lumen resulting in stabilization of RTKs and induction of Oct4 and Nanog.	bafilomycin	94-105	POU class 5 homeobox 1	Homo sapiens	215-219
35387234-8	2022	However, monensin, a chemical mimetic of Na+/H+ exchanger activity, and the H+ pump inhibitor bafilomycin bypassed NHE9 to directly alkalinize the endosomal lumen resulting in stabilization of RTKs and induction of Oct4 and Nanog.	bafilomycin	94-105	Nanog homeobox	Homo sapiens	224-229
3264168-6	1988	Bafilomycin also inhibited the growth of various lymphoid cell lines, the B cell line BCL1, the macrophage cell lines J774 and P338D1, and the T cell line EL4.	bafilomycin	0-11	cyclin D1	Mus musculus	86-90
35499056-10	2022	The autophagy inhibitors 3-MA, bafilomycin and chloroquine reversed the protective effects of LRRK2 deficiency.	bafilomycin	31-42	leucine-rich repeat kinase 2	Mus musculus	94-99
35203545-7	2022	Furthermore, the autophagy inhibitor Bafilomycin-A1 reproduced CXCR4 overexpression in control hMSCs confirming the direct effect of the autophagic degradation blockage on CXCR4 expression.	bafilomycin	37-48	C-X-C motif chemokine receptor 4	Homo sapiens	63-68
35203545-7	2022	Furthermore, the autophagy inhibitor Bafilomycin-A1 reproduced CXCR4 overexpression in control hMSCs confirming the direct effect of the autophagic degradation blockage on CXCR4 expression.	bafilomycin	37-48	C-X-C motif chemokine receptor 4	Homo sapiens	172-177
2527329-4	1989	The affinity of the partially purified ATPase from B. acidocaldarius for its substrates K+ (Km 2-3 microM) and ATP (Km 80 microM), its stimulation by various divalent cations, and its inhibition by vanadate (Ki 1-2 microM), bafilomycin A1 (Ki 20 microM), DCCD (Ki 200 microM) or Ca2+ were also similar to those of the E. coli enzyme, indicating that the two K+-translocating ATPases have almost identical properties.	bafilomycin	224-235	ATPase	Escherichia coli	39-45
3264168-6	1988	Bafilomycin also inhibited the growth of various lymphoid cell lines, the B cell line BCL1, the macrophage cell lines J774 and P338D1, and the T cell line EL4.	bafilomycin	0-11	epilepsy 4	Mus musculus	155-158
33684397-8	2021	The binding mode of the drugs with M-protein was analyzed and it was observed that Colchicine, Remdesivir, Bafilomycin A1 from COVID-19 suggested drugs and Temozolomide from SuperDRUG2 database displayed desirable molecular interactions and higher binding affinity towards M-protein.	bafilomycin	107-118	myomesin 2	Homo sapiens	35-44
33684397-8	2021	The binding mode of the drugs with M-protein was analyzed and it was observed that Colchicine, Remdesivir, Bafilomycin A1 from COVID-19 suggested drugs and Temozolomide from SuperDRUG2 database displayed desirable molecular interactions and higher binding affinity towards M-protein.	bafilomycin	107-118	myomesin 2	Homo sapiens	273-282
32990653-7	2020	Results: V-ATPase activity in PTs was markedly enhanced by insulin, and its activation was completely inhibited by bafilomycin (a V-ATPase-specific inhibitor), Akt inhibitor VIII, and PP242 (an mTORC1/2 inhibitor), but not by rapamycin (an mTORC1 inhibitor).	bafilomycin	115-126	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	9-17
32933997-9	2020	However, the addition of YAP inhibition with trametinib plus bafilomycin A1 resulted in cell death at comparable levels to trametinib plus chloroquine (T/CQ) treatment.	bafilomycin	61-72	Yes1 associated transcriptional regulator	Homo sapiens	25-28
33354770-9	2021	Rapamycin and bafilomycin A1 treatment showed that FUS KO cells were not able to initiate autophagy as efficiently as wild-type cells, suggesting that the autophagosome formation is affected in the absence of FUS.	bafilomycin	14-25	FUS RNA binding protein	Homo sapiens	51-54
33863987-6	2021	The atg5-morpholino knockdown and bafilomycin treatment partially improved the size of the liver and survival rate in larsb-/- zebrafish.	bafilomycin	34-45	leucyl-tRNA synthetase 1b	Danio rerio	118-123
33439776-7	2021	However, TNFalpha caused a strong upregulation of Cldn-3 in the presence of bafilomycin, suggesting an effect independent from lysosomes.	bafilomycin	76-87	tumor necrosis factor	Homo sapiens	9-17
33439776-7	2021	However, TNFalpha caused a strong upregulation of Cldn-3 in the presence of bafilomycin, suggesting an effect independent from lysosomes.	bafilomycin	76-87	claudin 3	Homo sapiens	50-56
33178023-8	2020	Among them, 3-methyladenine, SBI-0206965, Chloroquine, and Bafilomycin A1 triggered BAX- and/or BAK-dependent cytotoxicity and caspase activation.	bafilomycin	59-70	BCL2 associated X, apoptosis regulator	Homo sapiens	84-87
33178023-8	2020	Among them, 3-methyladenine, SBI-0206965, Chloroquine, and Bafilomycin A1 triggered BAX- and/or BAK-dependent cytotoxicity and caspase activation.	bafilomycin	59-70	BCL2 antagonist/killer 1	Homo sapiens	96-99
33116499-6	2020	Furthermore, blocking the fusion between autophagosomes and lysosomes by bafilomycin also significantly reduces Arg1, even in the presence of rapamycin.	bafilomycin	73-84	arginase 1	Homo sapiens	112-116
32990653-7	2020	Results: V-ATPase activity in PTs was markedly enhanced by insulin, and its activation was completely inhibited by bafilomycin (a V-ATPase-specific inhibitor), Akt inhibitor VIII, and PP242 (an mTORC1/2 inhibitor), but not by rapamycin (an mTORC1 inhibitor).	bafilomycin	115-126	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	130-138
32990653-7	2020	Results: V-ATPase activity in PTs was markedly enhanced by insulin, and its activation was completely inhibited by bafilomycin (a V-ATPase-specific inhibitor), Akt inhibitor VIII, and PP242 (an mTORC1/2 inhibitor), but not by rapamycin (an mTORC1 inhibitor).	bafilomycin	115-126	CREB regulated transcription coactivator 1	Mus musculus	194-200
32983576-7	2020	Bafilomycin-A1 treatment significantly increased caspase-1 and Pro-IL-1beta expression in normal and MCD keratocytes.	bafilomycin	0-11	caspase 1	Homo sapiens	49-58
32983576-7	2020	Bafilomycin-A1 treatment significantly increased caspase-1 and Pro-IL-1beta expression in normal and MCD keratocytes.	bafilomycin	0-11	interleukin 1 beta	Homo sapiens	63-75
32237184-9	2020	Inhibition of autophagy by bafilomycin rendered consistent expression of p62 indicating a defect in the final process of autophagy.	bafilomycin	27-38	nucleoporin 62	Homo sapiens	73-76
32126253-9	2020	The p62 and phospho-p62 levels were also increased by either ZnSO4 and bafilomycin A1 in HEK293 cells stably expressing RFP-LC3.	bafilomycin	71-82	sequestosome 1	Homo sapiens	4-7
32662244-7	2020	Furthermore, autophagy blockers chloroquine and bafilomycin A1 caused p16 aggregation within stalled vesicles containing autophagosome marker LC3.	bafilomycin	48-59	cyclin dependent kinase inhibitor 2A	Homo sapiens	70-73
32314441-7	2020	Secretion of soluble (P)RR into the medium was increased dose-dependently by bafilomycin A1 or chloroquine.	bafilomycin	77-88	ATPase H+ transporting accessory protein 2	Homo sapiens	21-26
32126253-9	2020	The p62 and phospho-p62 levels were also increased by either ZnSO4 and bafilomycin A1 in HEK293 cells stably expressing RFP-LC3.	bafilomycin	71-82	sequestosome 1	Homo sapiens	20-23
32111854-5	2020	The autophagy inhibitor bafilomycin caused a significant decrease in the production of Nrf2, HO-1 and NQO1 compared to DEPs treatment, whereas the Nrf2 activator sulforaphane increased the LC3B (p = 0.020) levels.	bafilomycin	24-35	NFE2 like bZIP transcription factor 2	Homo sapiens	87-91
32340354-7	2020	The inhibition of the lysosomal activity with bafilomycin or chloroquine prevented both LiCl- and SB216763-mediated downregulation of Aqp2 protein expression.	bafilomycin	46-57	aquaporin 2	Homo sapiens	134-138
32340354-8	2020	Bafilomycin and chloroquine induced the accumulation of Aqp2 in lysosomal structures, which was prevented in cells treated with dibutyryl cyclic adenosine monophosphate (dbcAMP), which led to phosphorylation and membrane localization of Aqp2.	bafilomycin	0-11	aquaporin 2	Homo sapiens	56-60
32340354-8	2020	Bafilomycin and chloroquine induced the accumulation of Aqp2 in lysosomal structures, which was prevented in cells treated with dibutyryl cyclic adenosine monophosphate (dbcAMP), which led to phosphorylation and membrane localization of Aqp2.	bafilomycin	0-11	aquaporin 2	Homo sapiens	237-241
32670268-10	2020	Inhibition of autophagy using bafilomycin-A1 reduced PINK1 expression in NHBF and restored the IL-17 mediated changes in PINK1 to their basal levels in DHBF.	bafilomycin	30-41	PTEN induced kinase 1	Homo sapiens	53-58
32670268-10	2020	Inhibition of autophagy using bafilomycin-A1 reduced PINK1 expression in NHBF and restored the IL-17 mediated changes in PINK1 to their basal levels in DHBF.	bafilomycin	30-41	interleukin 17A	Homo sapiens	95-100
32670268-10	2020	Inhibition of autophagy using bafilomycin-A1 reduced PINK1 expression in NHBF and restored the IL-17 mediated changes in PINK1 to their basal levels in DHBF.	bafilomycin	30-41	PTEN induced kinase 1	Homo sapiens	121-126
32670268-11	2020	Bafilomycin-A1 also reversed the IL-17 associated fibrotic response in these fibroblasts, suggesting a role for IL-17 induced autophagy in the induction of fibrosis in bronchial fibroblasts.	bafilomycin	0-11	interleukin 17A	Homo sapiens	33-38
32670268-11	2020	Bafilomycin-A1 also reversed the IL-17 associated fibrotic response in these fibroblasts, suggesting a role for IL-17 induced autophagy in the induction of fibrosis in bronchial fibroblasts.	bafilomycin	0-11	interleukin 17A	Homo sapiens	112-117
32111854-5	2020	The autophagy inhibitor bafilomycin caused a significant decrease in the production of Nrf2, HO-1 and NQO1 compared to DEPs treatment, whereas the Nrf2 activator sulforaphane increased the LC3B (p = 0.020) levels.	bafilomycin	24-35	heme oxygenase 1	Homo sapiens	93-97
32111854-5	2020	The autophagy inhibitor bafilomycin caused a significant decrease in the production of Nrf2, HO-1 and NQO1 compared to DEPs treatment, whereas the Nrf2 activator sulforaphane increased the LC3B (p = 0.020) levels.	bafilomycin	24-35	NAD(P)H quinone dehydrogenase 1	Homo sapiens	102-106
32111854-5	2020	The autophagy inhibitor bafilomycin caused a significant decrease in the production of Nrf2, HO-1 and NQO1 compared to DEPs treatment, whereas the Nrf2 activator sulforaphane increased the LC3B (p = 0.020) levels.	bafilomycin	24-35	microtubule associated protein 1 light chain 3 beta	Homo sapiens	189-193
31417125-6	2019	Western blotting assays revealed decreased expression of LC3 and increased levels of p62 even after treatment with the lysosomal inhibitor bafilomycin A1, indicating impairment of the autophagic flux.	bafilomycin	139-150	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	57-60
31097633-0	2020	Bafilomycin A1 targets patient-derived CD34CD19 leukemia stem cells.	bafilomycin	0-11	CD34 molecule	Homo sapiens	39-43
31310755-4	2019	Bafilomycin reduced the mRNA levels of anti-apoptotic Bcl-2, while chloroquine and ammonium chloride increased the mRNA expression of pro-apoptotic Pten and Puma, as well as anti-apoptotic Bcl-xL.	bafilomycin	0-11	B cell leukemia/lymphoma 2	Mus musculus	54-59
31310755-9	2019	p38 MAPK inhibitor SB203580 reduced the cytotoxicity of bafilomycin but increased that of chloroquine and ammonium chloride.	bafilomycin	56-67	mitogen-activated protein kinase 14	Mus musculus	0-8
31310755-10	2019	The pharmacological inhibition of ERK1/2, JNK, and AMPK potentiated the cytotoxicity of chloroquine, ammonium chloride, and bafilomycin, respectively.	bafilomycin	124-135	mitogen-activated protein kinase 3	Mus musculus	34-40
31310755-10	2019	The pharmacological inhibition of ERK1/2, JNK, and AMPK potentiated the cytotoxicity of chloroquine, ammonium chloride, and bafilomycin, respectively.	bafilomycin	124-135	mitogen-activated protein kinase 8	Mus musculus	42-45
31206981-2	2020	In the current study, the FRET system was employed to elucidate how brefeldin A (an endoplasmic reticulum stress inducer), chlorpromazine and apoptozole (lysosomal membrane destabilizers), bafilomycin A1 (an inhibitor of lysosomal acidification) as well as raptinal and Az-TPP-O3 (mitochondria-targeted apoptosis inducers) affect the interaction between Bax and Hsp70.	bafilomycin	189-200	BCL2 associated X, apoptosis regulator	Homo sapiens	354-357
31206981-2	2020	In the current study, the FRET system was employed to elucidate how brefeldin A (an endoplasmic reticulum stress inducer), chlorpromazine and apoptozole (lysosomal membrane destabilizers), bafilomycin A1 (an inhibitor of lysosomal acidification) as well as raptinal and Az-TPP-O3 (mitochondria-targeted apoptosis inducers) affect the interaction between Bax and Hsp70.	bafilomycin	189-200	heat shock protein family A (Hsp70) member 4	Homo sapiens	362-367
31515254-6	2019	On treatment with autophagy inhibitors bafilomycin A1 and chloroquine, ApoL9 is found near swollen mitochondria and on lysosomes/LAMP1-positive compartments.	bafilomycin	39-50	lysosomal-associated membrane protein 1	Mus musculus	129-134
31417125-6	2019	Western blotting assays revealed decreased expression of LC3 and increased levels of p62 even after treatment with the lysosomal inhibitor bafilomycin A1, indicating impairment of the autophagic flux.	bafilomycin	139-150	nucleoporin 62	Homo sapiens	85-88
30786016-7	2019	Treatment of HPV8-CER expressing cells with the autophagy inhibitor Bafilomycin A1 rescued CHK1 expression and led to LC3B accumulation.	bafilomycin	68-79	checkpoint kinase 1	Homo sapiens	91-95
30786016-7	2019	Treatment of HPV8-CER expressing cells with the autophagy inhibitor Bafilomycin A1 rescued CHK1 expression and led to LC3B accumulation.	bafilomycin	68-79	microtubule associated protein 1 light chain 3 beta	Homo sapiens	118-122
30909132-10	2019	Bafilomycin A1 upregulated LC3B-II expression and inhibited MUC secretion in HNE-treated normal primary HNECs.	bafilomycin	0-11	elastase, neutrophil expressed	Homo sapiens	77-80
30778048-8	2019	Further study showed that inhibition of autophagy by chloroquine or bafilomycin A1 reversed PBK-induced cisplatin resistance.	bafilomycin	68-79	PDZ binding kinase	Homo sapiens	92-95
30229906-5	2019	Bafilomycin-induced lysosomal dysfunction also resulted in mitochondrial Zn2+ accumulation, fragmentation, and ROS generation that were inhibited by PJ34 or 2-APB, suggesting that these mitochondrial events are TRPM2 dependent and sequela of lysosomal dysfunction.	bafilomycin	0-11	transient receptor potential cation channel subfamily M member 2	Homo sapiens	211-216
30737648-9	2019	An inhibitor of autophagy, 3-methyladenine or bafilomycin A1 significantly augmented GD-induced cleavage of caspase-3.	bafilomycin	46-57	caspase 3	Rattus norvegicus	108-117
30874545-7	2019	Combined with the inhibitor of autolysosome formation, Bafilomycin A1 (100 nM), SFN-NAC inhibited invasion via accumulating LC3 II and blocking formation of autolysosome.	bafilomycin	55-66	synuclein alpha	Homo sapiens	84-87
30717974-4	2019	Here, we showed that incubation of osteoclasts with the V-ATPase inhibitor bafilomycin A1 abolished the osteoclast-characteristic peripheral localization of secretory lysosomes, Rab7, and alpha-tubulin.	bafilomycin	75-86	RAB7A, member RAS oncogene family	Homo sapiens	178-182
30307767-6	2019	Moreover, addition of bafilomycin A1, an inhibitor of lysosomal function, abolished the protective effect of Klotho, indicating that the protective effect of Klotho was closely associated with lysosome function.	bafilomycin	22-33	klotho	Mus musculus	109-115
30307767-6	2019	Moreover, addition of bafilomycin A1, an inhibitor of lysosomal function, abolished the protective effect of Klotho, indicating that the protective effect of Klotho was closely associated with lysosome function.	bafilomycin	22-33	klotho	Mus musculus	158-164
30015858-9	2018	The use of the lysosomal inhibitors, bafilomycin and chloroquine, resulted in the accumulation of LC3II and Beclin 1, a decrease in the levels of LAMP2 and RAB7, and the exacerbation of allodynia, hyperalgesia and astrocyte activation in rats with neuropathic pain.	bafilomycin	37-48	beclin 1	Rattus norvegicus	108-116
30311874-7	2018	We further examined autophagy flux in cells replicating HCV RNA using bafilomycin or E64d, and found that the increase of LC3 lipidation by treatment with bafilomycin or E64d was impaired in HCV-replicating cells, suggesting that autophagy flux is inhibited by the progress of HCV infection.	bafilomycin	155-166	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	122-125
30420612-5	2018	Notably, the synergistic effect of IDF-11774 and the ATP6V0C inhibitor, bafilomycin A1, depended on the PIK3CA genetic status and Bcl-2 expression, which regulates autolysosome formation and apoptosis.	bafilomycin	72-83	ATPase H+ transporting V0 subunit c	Homo sapiens	53-60
30420612-5	2018	Notably, the synergistic effect of IDF-11774 and the ATP6V0C inhibitor, bafilomycin A1, depended on the PIK3CA genetic status and Bcl-2 expression, which regulates autolysosome formation and apoptosis.	bafilomycin	72-83	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	104-110
30420612-5	2018	Notably, the synergistic effect of IDF-11774 and the ATP6V0C inhibitor, bafilomycin A1, depended on the PIK3CA genetic status and Bcl-2 expression, which regulates autolysosome formation and apoptosis.	bafilomycin	72-83	BCL2 apoptosis regulator	Homo sapiens	130-135
30015858-9	2018	The use of the lysosomal inhibitors, bafilomycin and chloroquine, resulted in the accumulation of LC3II and Beclin 1, a decrease in the levels of LAMP2 and RAB7, and the exacerbation of allodynia, hyperalgesia and astrocyte activation in rats with neuropathic pain.	bafilomycin	37-48	lysosomal-associated membrane protein 2	Rattus norvegicus	146-151
30015858-9	2018	The use of the lysosomal inhibitors, bafilomycin and chloroquine, resulted in the accumulation of LC3II and Beclin 1, a decrease in the levels of LAMP2 and RAB7, and the exacerbation of allodynia, hyperalgesia and astrocyte activation in rats with neuropathic pain.	bafilomycin	37-48	RAB7A, member RAS oncogene family	Rattus norvegicus	156-160
29859188-6	2018	Furthermore, chloroquine or bafilomycin A1 treatment was able to restore TSG101-mediated AR expression reduction.	bafilomycin	28-39	tumor susceptibility 101	Homo sapiens	73-79
29859188-6	2018	Furthermore, chloroquine or bafilomycin A1 treatment was able to restore TSG101-mediated AR expression reduction.	bafilomycin	28-39	androgen receptor	Homo sapiens	89-91
29524554-3	2018	Our results indicate that autophagic flux was high in TSCC cells; Autophagy inhibitor bafilomycin A1 increased cisplatin cytotoxicity in TSCC cells by inhibiting lysosomal uptake of platinum and enhancing intracellular platinum ion binding to DNA; Autophagy gene (Atg5) knockout in TSCC cells did not duplicate the above-mentioned sensitization of bafilomycin A1.	bafilomycin	86-97	autophagy related 5	Homo sapiens	264-268
29501728-5	2018	Cathepsin C inhibition showed comparable autophagy blockade with E64d and augmented the autophagy blockade mediated by bafilomycin.	bafilomycin	119-130	cathepsin C	Homo sapiens	0-11
29563152-4	2018	We found that stimulation of glucagon secretion correlated with a PKA- and EPAC2-dependent (inhibited by PKI and ESI-05, respectively) elevation of [Ca2+]i in alpha-cells, which occurred without stimulation of electrical activity and persisted in the absence of extracellular Ca2+ but was sensitive to ryanodine, bafilomycin, and thapsigargin.	bafilomycin	313-324	Rap guanine nucleotide exchange factor 4	Homo sapiens	75-80
29318388-6	2018	Treatment with bafilomycin suppressed the enhancement of the renal gluconeogenesis enzymes phosphoenol pyruvate carboxykinase and glucose-6-phosphatase in diabetic rats and reduced the renal cytoplasmic glucose levels, whereas hepatic gluconeogenesis did not change significantly.	bafilomycin	15-26	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	130-151
29669713-8	2018	Suppression of the lysosomal degradation of iNOS by bafilomycin A1 drove septic cardiac dysfunction in myeloid HO-1-deficient mice.	bafilomycin	52-63	nitric oxide synthase 2, inducible	Mus musculus	44-48
29342507-7	2018	Blocking autophagic flux with bafilomycin resulted in the accumulation of misfolded HLA-B27 dimers and oligomers as well as monomers, which was comparable with the results of blocking endoplasmic reticulum-associated degradation (ERAD) with the proteasome inhibitor bortezomib.	bafilomycin	30-41	major histocompatibility complex, class I, B	Homo sapiens	84-91
29524503-7	2018	Bafilomycin A1 inhibited autophagy, steroidogenic factor 1 (SF1) protein and steroidogenesis in the present study.	bafilomycin	0-11	splicing factor 1	Rattus norvegicus	36-63
29663481-5	2018	Specific inhibition of v-ATPase with bafilomycin and KM91104 induced a down-regulation of the HSC fibrogenic gene profile, which coincided with increased lysosomal pH, decreased pHi, activation of AMPK, reduced proliferation, and lower metabolic activity.	bafilomycin	37-48	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	23-31
29663481-5	2018	Specific inhibition of v-ATPase with bafilomycin and KM91104 induced a down-regulation of the HSC fibrogenic gene profile, which coincided with increased lysosomal pH, decreased pHi, activation of AMPK, reduced proliferation, and lower metabolic activity.	bafilomycin	37-48	fucosyltransferase 1 (H blood group)	Homo sapiens	94-97
29663481-5	2018	Specific inhibition of v-ATPase with bafilomycin and KM91104 induced a down-regulation of the HSC fibrogenic gene profile, which coincided with increased lysosomal pH, decreased pHi, activation of AMPK, reduced proliferation, and lower metabolic activity.	bafilomycin	37-48	glucose-6-phosphate isomerase	Homo sapiens	178-181
29663481-5	2018	Specific inhibition of v-ATPase with bafilomycin and KM91104 induced a down-regulation of the HSC fibrogenic gene profile, which coincided with increased lysosomal pH, decreased pHi, activation of AMPK, reduced proliferation, and lower metabolic activity.	bafilomycin	37-48	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	197-201
30094371-4	2018	Bafilomycin is a specific inhibitor of V-ATPase.	bafilomycin	0-11	dynein axonemal heavy chain 8	Homo sapiens	39-47
29514909-5	2018	We find that Nef decreases both Ser5 and CD4 expression at steady-state levels, which are rescued by NH4Cl or bafilomycin A1 treatment.	bafilomycin	110-121	S100 calcium binding protein B	Homo sapiens	13-16
29514909-5	2018	We find that Nef decreases both Ser5 and CD4 expression at steady-state levels, which are rescued by NH4Cl or bafilomycin A1 treatment.	bafilomycin	110-121	serine incorporator 5	Homo sapiens	32-36
29514909-5	2018	We find that Nef decreases both Ser5 and CD4 expression at steady-state levels, which are rescued by NH4Cl or bafilomycin A1 treatment.	bafilomycin	110-121	CD4 molecule	Homo sapiens	41-44
29514909-10	2018	Finally, Nef promotes Ser5 colocalization with LAMP1, which is enhanced by bafilomycin A1 treatment, suggesting that Ser5 is targeted to lysosomes for destruction.	bafilomycin	75-86	S100 calcium binding protein B	Homo sapiens	9-12
29514909-10	2018	Finally, Nef promotes Ser5 colocalization with LAMP1, which is enhanced by bafilomycin A1 treatment, suggesting that Ser5 is targeted to lysosomes for destruction.	bafilomycin	75-86	serine incorporator 5	Homo sapiens	22-26
29514909-10	2018	Finally, Nef promotes Ser5 colocalization with LAMP1, which is enhanced by bafilomycin A1 treatment, suggesting that Ser5 is targeted to lysosomes for destruction.	bafilomycin	75-86	lysosomal associated membrane protein 1	Homo sapiens	47-52
29514909-10	2018	Finally, Nef promotes Ser5 colocalization with LAMP1, which is enhanced by bafilomycin A1 treatment, suggesting that Ser5 is targeted to lysosomes for destruction.	bafilomycin	75-86	serine incorporator 5	Homo sapiens	117-121
29796178-8	2018	Conversely, however, HO-1 expression by SB202190 became completely suppressed by the autophagy inhibitor bafilomycin A1.	bafilomycin	105-116	heme oxygenase 1	Homo sapiens	21-25
29422602-3	2018	Rats daily administered 20 mM methylglyoxal intraperitoneally developed significant peritoneal fibrosis after 7 days with increased expression of TGF-beta and V-ATPase, which was reduced by the inhibition of V-ATPase with co-administration of 100 mM bafilomycin A1.	bafilomycin	250-261	transforming growth factor, beta 1	Rattus norvegicus	146-154
29260183-5	2018	It also resulted in the rapid movement of DMT1 to lysosomes, which was inhibited by bafilomycin.	bafilomycin	84-95	solute carrier family 11 member 2	Homo sapiens	42-46
29253572-4	2018	The dual PI3K/AKT and mTOR inhibitor BEZ235 suppressed sCLU expression and enhanced cell sensitivity induced by bafilomycin A1.	bafilomycin	112-123	AKT serine/threonine kinase 1	Homo sapiens	14-17
29253572-4	2018	The dual PI3K/AKT and mTOR inhibitor BEZ235 suppressed sCLU expression and enhanced cell sensitivity induced by bafilomycin A1.	bafilomycin	112-123	mechanistic target of rapamycin kinase	Homo sapiens	22-26
29196261-5	2018	Experiments using cycloheximide, MG132 and bafilomycin A1 have revealed that Sox9 is degraded through the ubiquitin-proteasome pathway and that A-674563 inhibits this degradation, resulting in larger amount of Sox9 protein.	bafilomycin	43-54	SRY (sex determining region Y)-box 9	Mus musculus	77-81
27875637-9	2018	Silencing AMBRA1 function caused aggregates of alpha-synuclein in the cytoplasm of mouse primary cultured neurons, which was simulated by the treatment of Bafilomycin, an autophagy inhibitor.	bafilomycin	155-166	autophagy/beclin 1 regulator 1	Mus musculus	10-16
27875637-9	2018	Silencing AMBRA1 function caused aggregates of alpha-synuclein in the cytoplasm of mouse primary cultured neurons, which was simulated by the treatment of Bafilomycin, an autophagy inhibitor.	bafilomycin	155-166	synuclein, alpha	Mus musculus	47-62
30138927-6	2018	METHODS: NLRP3 inflammasomes were activated in human RPE cells by blocking proteasomes and autophagy using MG-132 and bafilomycin A1 (BafA), respectively.	bafilomycin	118-129	NLR family pyrin domain containing 3	Homo sapiens	9-14
29416015-7	2018	Bafilomycin-induced lysosomal dysfunction also resulted in TRPM2-dependent cytosolic Zn2+ increase, mitochondrial Zn2+ accumulation, and mitochondrial generation of ROS, supporting that lysosomal dysfunction and accompanying Zn2+ release trigger mitochondrial Zn2+ accumulation and generation of ROS.	bafilomycin	0-11	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	59-64
29074359-10	2017	Furthermore, vacuolar proton (V)-ATPases inhibitor bafilomycin A1 and lysosomal proteases inhibitor leupeptin could remarkably overturn the levels of Cdc25C in xanthatin-treated H1299 cells.	bafilomycin	51-62	cell division cycle 25C	Homo sapiens	150-156
29096331-3	2017	Autophagy inhibitors 3-methyladenine and bafilomycin block the effect of NS targeting on differentiation, indicating a new functional link between NS and autophagy as an important regulator of differentiation in NB4 cells.	bafilomycin	41-52	G protein nucleolar 3	Homo sapiens	73-75
29096331-3	2017	Autophagy inhibitors 3-methyladenine and bafilomycin block the effect of NS targeting on differentiation, indicating a new functional link between NS and autophagy as an important regulator of differentiation in NB4 cells.	bafilomycin	41-52	G protein nucleolar 3	Homo sapiens	147-149
27832521-6	2017	Blockade of autophagy flux with autophagy inhibitor 3-methyladenine or bafilomycin A1 resulted in further phosphorylation of p38alpha, polyubiquitinated protein aggregation, and greater apoptotic cell death.	bafilomycin	71-82	mitogen-activated protein kinase 14	Homo sapiens	125-133
28852804-9	2017	These podocytes lose expression of the IR as a direct consequence of prolonged exposure to high insulin concentrations, which causes an increase in IR protein degradation via a proteasome-dependent and bafilomycin-sensitive pathway.	bafilomycin	202-213	insulin receptor	Homo sapiens	39-41
28852804-9	2017	These podocytes lose expression of the IR as a direct consequence of prolonged exposure to high insulin concentrations, which causes an increase in IR protein degradation via a proteasome-dependent and bafilomycin-sensitive pathway.	bafilomycin	202-213	insulin	Homo sapiens	96-103
28852804-9	2017	These podocytes lose expression of the IR as a direct consequence of prolonged exposure to high insulin concentrations, which causes an increase in IR protein degradation via a proteasome-dependent and bafilomycin-sensitive pathway.	bafilomycin	202-213	insulin receptor	Homo sapiens	148-150
28767320-6	2017	Notably, the si-UBE2C-induced decrease in cell viability was markedly inhibited by the autophagy inhibitor bafilomycin A1.	bafilomycin	107-118	ubiquitin conjugating enzyme E2 C	Homo sapiens	16-21
28984290-7	2017	The autophagy inhibitors, 3-methyladenine (3-MA) and bafilomycin A1, did not affect viral replication, but significantly inhibited the cytotoxicity of RH2.	bafilomycin	53-64	Rh associated glycoprotein	Homo sapiens	151-154
28904818-7	2017	Bafilomycin, which blocked degradation of LC3 in lysosomes, caused both LC3I and LC3II accumulation.	bafilomycin	0-11	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	42-45
28378122-6	2017	Both cathepsins B (Ca-074 Me) and D (Pepstatin A) inhibitors as well as Bafilomycin A1 prevented caspases-3, -7, -8 and -9 activation, FasL upregulation, Bid cleavage, Deltaphim disruption and cytochrome c release.	bafilomycin	72-83	Fas ligand	Homo sapiens	135-139
28378122-6	2017	Both cathepsins B (Ca-074 Me) and D (Pepstatin A) inhibitors as well as Bafilomycin A1 prevented caspases-3, -7, -8 and -9 activation, FasL upregulation, Bid cleavage, Deltaphim disruption and cytochrome c release.	bafilomycin	72-83	BH3 interacting domain death agonist	Homo sapiens	154-157
28378122-6	2017	Both cathepsins B (Ca-074 Me) and D (Pepstatin A) inhibitors as well as Bafilomycin A1 prevented caspases-3, -7, -8 and -9 activation, FasL upregulation, Bid cleavage, Deltaphim disruption and cytochrome c release.	bafilomycin	72-83	cytochrome c, somatic	Homo sapiens	193-205
28559895-13	2017	Blockade of autophagy by Atg5 siRNA or bafilomycin A1 attenuated the inhibitory effect of PNU282987 on IL-6, IL-1beta, IL-18, and TNF-alpha mRNA.	bafilomycin	39-50	interleukin 6	Mus musculus	103-107
28470757-4	2017	Furthermore, PTHrP increases ATP6V0D2 expression and induces proton generation by primary osteocytes, which is blocked by bafilomycin, a vacuolar ATPase inhibitor.	bafilomycin	122-133	parathyroid hormone-like peptide	Mus musculus	13-18
28470757-4	2017	Furthermore, PTHrP increases ATP6V0D2 expression and induces proton generation by primary osteocytes, which is blocked by bafilomycin, a vacuolar ATPase inhibitor.	bafilomycin	122-133	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	29-37
28751712-5	2017	Herein, carbonyl cyanide m-chlorophenyl hydrazone (CCCP)-induced mitochondrial depolarization decreased mitochondrial mass and Mfn2 levels, which were rescued with mitophagy blocker, bafilomycin, in FECD.	bafilomycin	183-194	mitofusin 2	Homo sapiens	127-131
28751712-5	2017	Herein, carbonyl cyanide m-chlorophenyl hydrazone (CCCP)-induced mitochondrial depolarization decreased mitochondrial mass and Mfn2 levels, which were rescued with mitophagy blocker, bafilomycin, in FECD.	bafilomycin	183-194	collagen type VIII alpha 2 chain	Homo sapiens	199-203
28388007-8	2017	Notably, treatment of sensitive N87 cells with the V-ATPase selective inhibitor bafilomycin A1 induced T-DM1 resistance, suggesting that aberrant V-ATPase activity decreases T-DM1 metabolism, leading to T-DM1 resistance in N87-KR cells.	bafilomycin	80-91	immunoglobulin heavy diversity 1-7	Homo sapiens	105-108
28388007-8	2017	Notably, treatment of sensitive N87 cells with the V-ATPase selective inhibitor bafilomycin A1 induced T-DM1 resistance, suggesting that aberrant V-ATPase activity decreases T-DM1 metabolism, leading to T-DM1 resistance in N87-KR cells.	bafilomycin	80-91	immunoglobulin heavy diversity 1-7	Homo sapiens	176-179
28388007-8	2017	Notably, treatment of sensitive N87 cells with the V-ATPase selective inhibitor bafilomycin A1 induced T-DM1 resistance, suggesting that aberrant V-ATPase activity decreases T-DM1 metabolism, leading to T-DM1 resistance in N87-KR cells.	bafilomycin	80-91	immunoglobulin heavy diversity 1-7	Homo sapiens	176-179
28363601-5	2017	Autophagy inhibition with bafilomycin or chloroquine prevented the decrease in Trx1 and Glo2 at 6 and 18h after MGO treatment.	bafilomycin	26-37	thioredoxin 1	Mus musculus	79-83
28363601-5	2017	Autophagy inhibition with bafilomycin or chloroquine prevented the decrease in Trx1 and Glo2 at 6 and 18h after MGO treatment.	bafilomycin	26-37	hydroxyacyl glutathione hydrolase	Mus musculus	88-92
28824718-8	2017	Bafilomycin A1, an inhibitor of autolysosome formation, abolished the rectifying effect of anti-CXCL10 mAb or CXCL10 knockdown in AML-12 and primary hepatocytes, indicating CXCL10 impaired late-stage autophagy in NAFLD.	bafilomycin	0-11	chemokine (C-X-C motif) ligand 10	Mus musculus	96-102
28824718-8	2017	Bafilomycin A1, an inhibitor of autolysosome formation, abolished the rectifying effect of anti-CXCL10 mAb or CXCL10 knockdown in AML-12 and primary hepatocytes, indicating CXCL10 impaired late-stage autophagy in NAFLD.	bafilomycin	0-11	chemokine (C-X-C motif) ligand 10	Mus musculus	110-116
28824718-8	2017	Bafilomycin A1, an inhibitor of autolysosome formation, abolished the rectifying effect of anti-CXCL10 mAb or CXCL10 knockdown in AML-12 and primary hepatocytes, indicating CXCL10 impaired late-stage autophagy in NAFLD.	bafilomycin	0-11	chemokine (C-X-C motif) ligand 10	Mus musculus	110-116
28179072-6	2017	However, reducing the expression of Orai3 channel resulted in larger [Ca2+]i response after TG but only when the ER store had been overloaded with Ca2+ by eliminating the acidic internal Ca2+ store with bafilomycin.	bafilomycin	203-214	ORAI calcium release-activated calcium modulator 3	Homo sapiens	36-41
28396174-7	2017	In addition, the autophagy inhibitor 3-MA and bafilomycin A1 partially prevented the effects of Sirt3 on LDH release and apoptosis after OGD.	bafilomycin	46-57	sirtuin 3	Homo sapiens	96-101
28106723-6	2017	Further research using 3-methyladenine (3-MA), bafilomycin A1, and ad-mCherry-GFP-LC3B adenovirus demonstrated that LC3B-II increase induced by TNF-alpha was attributed to the inhibition of autophagic degradation.	bafilomycin	47-58	microtubule associated protein 1 light chain 3 beta	Homo sapiens	116-120
28254863-10	2017	Finally, combining bafilomycin A1 with the osteoclast inhibitor zoledronic acid was sufficient to ameliorate MMBP, which was refractory to zoledronic acid.	bafilomycin	19-30	proteoglycan 2, bone marrow	Mus musculus	109-113
28466054-8	2017	This analysis revealed that bafilomycin has high docking score and thus high binding affinity with E2 protein suggesting stable protein-ligand interaction.	bafilomycin	28-39	ubiquitin conjugating enzyme E2 B	Homo sapiens	99-109
28082421-6	2017	Trpm2+/+ macrophages treated with the vacuolar H+-ATPase inhibitor bafilomycin showed reduced bacterial clearance, similar to that in Trpm2-/- macrophages.	bafilomycin	67-78	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	0-5
28082421-6	2017	Trpm2+/+ macrophages treated with the vacuolar H+-ATPase inhibitor bafilomycin showed reduced bacterial clearance, similar to that in Trpm2-/- macrophages.	bafilomycin	67-78	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	134-139
28262793-8	2017	Interestingly, lysosomal Ca2+ content and bafilomycin A1-induced [Ca2+]i increases were enhanced in Sgpl1-/--MEFs, contrary to NPC.	bafilomycin	42-53	sphingosine phosphate lyase 1	Mus musculus	100-105
28126413-4	2017	Bafilomycin A1 treatment of particle-exposed macrophages also resulted in decreased active cathepsin L in the cytosol, a surrogate measure for leaked cathepsin B, which was associated with less NLRP3 inflammasome activity.	bafilomycin	0-11	cathepsin L	Mus musculus	91-102
28126413-4	2017	Bafilomycin A1 treatment of particle-exposed macrophages also resulted in decreased active cathepsin L in the cytosol, a surrogate measure for leaked cathepsin B, which was associated with less NLRP3 inflammasome activity.	bafilomycin	0-11	cathepsin B	Mus musculus	150-161
28126413-4	2017	Bafilomycin A1 treatment of particle-exposed macrophages also resulted in decreased active cathepsin L in the cytosol, a surrogate measure for leaked cathepsin B, which was associated with less NLRP3 inflammasome activity.	bafilomycin	0-11	NLR family, pyrin domain containing 3	Mus musculus	194-199
28106723-6	2017	Further research using 3-methyladenine (3-MA), bafilomycin A1, and ad-mCherry-GFP-LC3B adenovirus demonstrated that LC3B-II increase induced by TNF-alpha was attributed to the inhibition of autophagic degradation.	bafilomycin	47-58	tumor necrosis factor	Homo sapiens	144-153
27121029-5	2016	The V-ATPase inhibitor bafilomycin A1 partially blocked prorenin-induced (P) RR, FN, and alpha-SMA expression.	bafilomycin	23-34	actin gamma 2, smooth muscle	Rattus norvegicus	89-98
28395338-10	2017	To determine the role of V-ATPase instead of a single subunit in embryo implantation, a specific V-ATPase inhibitor bafilomycin A1 (2.5 mug/kg) was injected via uterine fat pad on D3 18:00 h. This treatment resulted in reduced uterine epithelial acidification, delayed implantation, and reduced number of implantation sites.	bafilomycin	116-127	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	97-105
27534900-4	2017	When autophagy was induced by rapamycin or inhibited by bafilomycin A1 in fetal liver cells, we observed a significant decrease in high ploidy megakaryocytes, a reduction of CD41 and CD61 co-expressing cells, and less proplatelet or platelet formation.	bafilomycin	56-67	integrin alpha 2b	Mus musculus	174-178
27534900-4	2017	When autophagy was induced by rapamycin or inhibited by bafilomycin A1 in fetal liver cells, we observed a significant decrease in high ploidy megakaryocytes, a reduction of CD41 and CD61 co-expressing cells, and less proplatelet or platelet formation.	bafilomycin	56-67	integrin beta 3	Mus musculus	183-187
27494711-6	2016	Cilostazol increased cathepsin B activity and decreased p62/SQSTM 1, consequently decreased accumulation of Abeta1-42 in the activated N2aSwe cells, and these results were blocked by sirtinol, compound C and bafilomycin A1 (autophagosome blocker), suggesting enhanced autophagosome formation by cilostazol.	bafilomycin	208-219	sequestosome 1	Mus musculus	60-67
27680548-8	2016	Mst1 knockdown also promoted autophagic flux in the presence of bafilomycin A1.	bafilomycin	64-75	macrophage stimulating 1 (hepatocyte growth factor-like)	Mus musculus	0-4
27496379-10	2016	Mst1 knockdown also enhanced autophagic flux as evidenced by GFP-mRFP-LC3 staining, increased LC3-II expression and decreased p62 expression in the presence of bafilomycin A1.	bafilomycin	160-171	macrophage stimulating 1 (hepatocyte growth factor-like)	Mus musculus	0-4
27343732-5	2016	Env was rapidly degraded in the absence of Vpr, which was blocked by the ERAD pathway inhibitor kifunesine or the lysosome inhibitor Bafilomycin.	bafilomycin	133-144	endogenous retrovirus group K member 20	Homo sapiens	0-3
27343732-5	2016	Env was rapidly degraded in the absence of Vpr, which was blocked by the ERAD pathway inhibitor kifunesine or the lysosome inhibitor Bafilomycin.	bafilomycin	133-144	Vpr	Human immunodeficiency virus 1	43-46
27246255-7	2016	ROCK1 knockdown decreased amyloid precursor protein (APP), and treatment with bafilomycin accumulated APP levels in neurons depleted of ROCK1.	bafilomycin	78-89	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	136-141
27477609-3	2016	SLC17A9-mediated ATP transport across the lysosomal membrane is suppressed by Bafilomycin A1, the V-ATPase inhibitor.	bafilomycin	78-89	solute carrier family 17 member 9	Homo sapiens	0-7
27477609-8	2016	In this study, we report that SLC17A9-mediated ATP transport across lysosomal membranes is suppressed by Bafilomycin A1, the V-ATPase inhibitor.	bafilomycin	105-116	solute carrier family 17 member 9	Homo sapiens	30-37
27099307-6	2016	Inhibition of lysosomal acidification by bafilomycin rescues the decreased release of virions from syntaxin 17-overexpressing cells, while induction of autophagy by rapamycin enforces the impairment of release under these conditions.	bafilomycin	41-52	syntaxin 17	Homo sapiens	99-110
26242265-3	2016	SGC-7901 gastric cancer cell line was treated with 5-fluorouracil (5-FU) or/and autophagy inhibitor bafilomycin A1.	bafilomycin	100-111	sarcoglycan beta	Homo sapiens	0-3
26659860-4	2016	In contrast, in the presence of bafilomycin, an inhibitor of late stages of autophagy and degradation in the autophagolysosome, syncytiotrophoblasts exposed to starvation, rapamycin, or punicalagin all showed increased levels of LC3-II and p62.	bafilomycin	32-43	nucleoporin 62	Homo sapiens	240-243
26764007-6	2016	We observe that the autophagy markers LC3b and lysosome-associated membrane protein 2A (LAMP2A) localize to a subset of TRIM5alpha cytoplasmic bodies, and inhibition of lysosomal degradation with bafilomycin A1 increases this association.	bafilomycin	196-207	microtubule associated protein 1 light chain 3 beta	Homo sapiens	38-42
26538438-5	2016	Punctate accumulation of NBD-MTMA was markedly reduced by coexposure of MATE1-expressing cells with 5 muM bafilomycin (BAF), an inhibitor of V-type H(+)-ATPase, and accumulation of [(3)H]MPP and [(3)H]NBD-MTMA was reduced by >30% by coexposure with 5 muM BAF.	bafilomycin	106-117	solute carrier family 47 member 1	Homo sapiens	72-77
26054709-5	2016	Enzyme-linked immunosorbent assays showed that bafilomycin A1 can significantly decrease the subtoxic concentration of CoNP-induced levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6), but has no effect on anti-inflammatory cytokines (transforming growth factor-beta and interleukin-10) in RAW264.7 cells.	bafilomycin	47-58	tumor necrosis factor	Mus musculus	170-197
26054709-5	2016	Enzyme-linked immunosorbent assays showed that bafilomycin A1 can significantly decrease the subtoxic concentration of CoNP-induced levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6), but has no effect on anti-inflammatory cytokines (transforming growth factor-beta and interleukin-10) in RAW264.7 cells.	bafilomycin	47-58	interleukin 1 beta	Mus musculus	199-216
26054709-5	2016	Enzyme-linked immunosorbent assays showed that bafilomycin A1 can significantly decrease the subtoxic concentration of CoNP-induced levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6), but has no effect on anti-inflammatory cytokines (transforming growth factor-beta and interleukin-10) in RAW264.7 cells.	bafilomycin	47-58	interleukin 6	Mus musculus	222-235
26054709-5	2016	Enzyme-linked immunosorbent assays showed that bafilomycin A1 can significantly decrease the subtoxic concentration of CoNP-induced levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6), but has no effect on anti-inflammatory cytokines (transforming growth factor-beta and interleukin-10) in RAW264.7 cells.	bafilomycin	47-58	interleukin 10	Mus musculus	324-338
26410677-5	2016	The analysis on Tctex-1 protein was performed in the absence and presence of the ligands JWH 133, 2-AG, and AM 630, the protein biosynthesis inhibitor cycloheximide or the protein degradation blockers MG132, NH4Cl/leupeptin or bafilomycin.	bafilomycin	227-238	dynein light chain Tctex-type 1	Homo sapiens	16-23
27467688-7	2016	WNK3 significantly increased NCC protein expression in both NCC alone and WNK3 + NCC groups regardless the overnight treatments of bafilomycin A1, a proton pump inhibitor, suggesting that WNK3-mediated increased NCC expression is not dependent on the lysosomal pathway.	bafilomycin	131-142	WNK lysine deficient protein kinase 3 S homeolog	Xenopus laevis	0-4
26926601-7	2016	Bafilomycin inhibited insulin-induced activation of eNOS (64.7 +- 22% to -47.8 +- 8%, P = 0.04) in cells from controls, confirming that intact autophagy is necessary for eNOS signaling.	bafilomycin	0-11	insulin	Homo sapiens	22-29
26926601-11	2016	Blocking the terminal stage of autophagy with bafilomycin increased p62 (P = 0.01) in cells from diabetics to a lesser extent than in cells from controls (P = 0.04), suggesting ongoing, but inadequate autophagic clearance.	bafilomycin	46-57	nucleoporin 62	Homo sapiens	68-71
26763850-6	2016	Functionally, both the lysosome inhibitor bafilomycin A1 and the ASMase inhibitor amitriptyline reversed Ang II-induced impairment of vasodilation.	bafilomycin	42-53	angiotensinogen	Rattus norvegicus	105-111
26744456-8	2016	Extraordinarily, pretreatment with bafilomycin A1(Baf-A1) led to a comparable [Ca(2+)]i increase pattern between these two groups, suggesting that calcium traffic from the intracellular acidic compartment is defective in Sidt2(-/-) beta-cells.	bafilomycin	35-46	SID1 transmembrane family, member 2	Mus musculus	221-226
26957005-8	2016	We establish a causal relationship between increased alpha-SNC release by exophagy and JNK activation subsequent to lysosomal fusion deficiency (overexpression of Lewy body-localized protein p25alpha or bafilomycin A1).	bafilomycin	203-214	synuclein alpha	Rattus norvegicus	53-62
26957005-8	2016	We establish a causal relationship between increased alpha-SNC release by exophagy and JNK activation subsequent to lysosomal fusion deficiency (overexpression of Lewy body-localized protein p25alpha or bafilomycin A1).	bafilomycin	203-214	mitogen-activated protein kinase 8	Rattus norvegicus	87-90
26382247-5	2015	In addition, the HLA-E:G peptide complex triggered NKG2C receptor internalization, as evidenced by reduction in the percentage of NKG2C+ NK cells when incubated with the peptide, which could be restored by addition of Bafilomycin.	bafilomycin	218-229	major histocompatibility complex, class I, E	Homo sapiens	17-22
26120766-6	2015	Introducing bafilomycin to Earle"s balanced salt solution or to OSS condition incrementally increased both LC3-II/LC3-I ratios and p62 levels, implicating impaired autophagic flux.	bafilomycin	12-23	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	107-110
26120766-6	2015	Introducing bafilomycin to Earle"s balanced salt solution or to OSS condition incrementally increased both LC3-II/LC3-I ratios and p62 levels, implicating impaired autophagic flux.	bafilomycin	12-23	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	114-117
26120766-6	2015	Introducing bafilomycin to Earle"s balanced salt solution or to OSS condition incrementally increased both LC3-II/LC3-I ratios and p62 levels, implicating impaired autophagic flux.	bafilomycin	12-23	nucleoporin 62	Homo sapiens	131-134
26352258-8	2015	Delivery of GGTI to human pancreatic cancer cells was demonstrated by the inhibition of protein geranylgeranylation inside the cell and this effect was blocked by Bafilomycin A1.	bafilomycin	163-174	protein geranylgeranyltransferase type I subunit beta	Homo sapiens	12-16
26001614-5	2015	Inhibition of lysosomal degradation with Bafilomycin A1 pretreatment abrogated the TNF-induced elevation in LC3II protein level whereas autophagy inhibitor 3-methyladenine did not affect it.	bafilomycin	41-52	tumor necrosis factor	Rattus norvegicus	83-86
26682054-4	2015	Bafilomycin and chloroquine, agents that inhibit the function of endosomal toll-like receptors (TLRs), significantly reduced the capacity of TLR3-, TLR7- and TLR-9-stimulated cells to produce IFN-alpha and the IFN-induced chemokine CXCL10 (IP-10).	bafilomycin	0-11	interferon alpha 1	Homo sapiens	192-201
26682054-5	2015	In contrast, only bafilomycin (but not chloroquine) effectively suppressed HRV16-stimulated IFN-alpha and IP-10 production, whereas neither bafilomycin or chloroquine inhibited HRV16-stimulated interleukin-6 release.	bafilomycin	18-29	interferon alpha 1	Homo sapiens	92-101
26500823-5	2015	Both drug uptake and retention are extensively inhibited by treatments with the V-ATPase inhibitor bafilomycin A1.	bafilomycin	99-110	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	80-88
26382247-5	2015	In addition, the HLA-E:G peptide complex triggered NKG2C receptor internalization, as evidenced by reduction in the percentage of NKG2C+ NK cells when incubated with the peptide, which could be restored by addition of Bafilomycin.	bafilomycin	218-229	killer cell lectin like receptor C2	Homo sapiens	51-56
26382247-5	2015	In addition, the HLA-E:G peptide complex triggered NKG2C receptor internalization, as evidenced by reduction in the percentage of NKG2C+ NK cells when incubated with the peptide, which could be restored by addition of Bafilomycin.	bafilomycin	218-229	killer cell lectin like receptor C2	Homo sapiens	130-135
25145935-7	2015	Similarly, pretreatment of HEK-BKalpha cells with the lysosomal inhibitor bafilomycin A1 reversed the inhibitory effects of WNK1 siRNA on BKalpha expression in a dose-dependent manner.	bafilomycin	74-85	FCF1 rRNA-processing protein	Homo sapiens	31-38
26020805-4	2015	Treating GBM organotypic cultures or neurospheres with the selective V-ATPase inhibitor bafilomycin A1 reproduced the effects of ATP6V1G1 siRNA and strongly suppressed expression of the stem cell markers Nestin, CD133 and transcription factors SALL2 and POU3F2 in neurospheres.These data point to ATP6V1G1 as a novel marker of poor prognosis in GBM patients and identify V-ATPase inhibition as an innovative therapeutic strategy for GBM.	bafilomycin	88-99	ATPase H+ transporting V1 subunit G1	Homo sapiens	129-137
26020805-4	2015	Treating GBM organotypic cultures or neurospheres with the selective V-ATPase inhibitor bafilomycin A1 reproduced the effects of ATP6V1G1 siRNA and strongly suppressed expression of the stem cell markers Nestin, CD133 and transcription factors SALL2 and POU3F2 in neurospheres.These data point to ATP6V1G1 as a novel marker of poor prognosis in GBM patients and identify V-ATPase inhibition as an innovative therapeutic strategy for GBM.	bafilomycin	88-99	prominin 1	Homo sapiens	212-217
26020805-4	2015	Treating GBM organotypic cultures or neurospheres with the selective V-ATPase inhibitor bafilomycin A1 reproduced the effects of ATP6V1G1 siRNA and strongly suppressed expression of the stem cell markers Nestin, CD133 and transcription factors SALL2 and POU3F2 in neurospheres.These data point to ATP6V1G1 as a novel marker of poor prognosis in GBM patients and identify V-ATPase inhibition as an innovative therapeutic strategy for GBM.	bafilomycin	88-99	spalt like transcription factor 2	Homo sapiens	244-249
26020805-4	2015	Treating GBM organotypic cultures or neurospheres with the selective V-ATPase inhibitor bafilomycin A1 reproduced the effects of ATP6V1G1 siRNA and strongly suppressed expression of the stem cell markers Nestin, CD133 and transcription factors SALL2 and POU3F2 in neurospheres.These data point to ATP6V1G1 as a novel marker of poor prognosis in GBM patients and identify V-ATPase inhibition as an innovative therapeutic strategy for GBM.	bafilomycin	88-99	POU class 3 homeobox 2	Homo sapiens	254-260
26020805-4	2015	Treating GBM organotypic cultures or neurospheres with the selective V-ATPase inhibitor bafilomycin A1 reproduced the effects of ATP6V1G1 siRNA and strongly suppressed expression of the stem cell markers Nestin, CD133 and transcription factors SALL2 and POU3F2 in neurospheres.These data point to ATP6V1G1 as a novel marker of poor prognosis in GBM patients and identify V-ATPase inhibition as an innovative therapeutic strategy for GBM.	bafilomycin	88-99	ATPase H+ transporting V1 subunit G1	Homo sapiens	297-305
26040000-6	2015	Immunofluorescence showed that PLN and the autophagy marker, microtubule light chain 3, became increasingly colocalized in response to chloroquine and bafilomycin treatments.	bafilomycin	151-162	phospholamban	Mus musculus	31-34
25838426-5	2015	The effects of an LXR agonist and acetylated low-density lipoprotein on the degradation of csABCA1 were repressed completely by treatment with bafilomycin, an inhibitor of lysosomal degradation, and by depletion of tumor susceptibility gene 101, a major component of endosomal sorting complex required for transport-I.	bafilomycin	143-154	nuclear receptor subfamily 1, group H, member 2	Mus musculus	18-21
25961570-14	2015	Pharmacological inhibitors of lysosomal degradation, such as ammonium chloride and bafilomycin, prevented IFNAR1 degradation in FFA-treated HCV cell culture.	bafilomycin	83-94	interferon alpha and beta receptor subunit 1	Homo sapiens	106-112
25145935-7	2015	Similarly, pretreatment of HEK-BKalpha cells with the lysosomal inhibitor bafilomycin A1 reversed the inhibitory effects of WNK1 siRNA on BKalpha expression in a dose-dependent manner.	bafilomycin	74-85	WNK lysine deficient protein kinase 1	Homo sapiens	124-128
25145935-7	2015	Similarly, pretreatment of HEK-BKalpha cells with the lysosomal inhibitor bafilomycin A1 reversed the inhibitory effects of WNK1 siRNA on BKalpha expression in a dose-dependent manner.	bafilomycin	74-85	FCF1 rRNA-processing protein	Homo sapiens	138-145
25339765-4	2015	When GLUT1 was translocated into the plasma membrane from intracellular storage sites by bafilomycin A1 (BFLA1) treatment in 293T cells, HTLV-1 Env-mediated cell fusion and infection also were inhibited without the overexpression of GLUT1, indicating that the localization of GLUT1 in intracellular compartments rather than in the plasma membrane is crucial for the fusion activity of HTLV-1 Env.	bafilomycin	89-100	solute carrier family 2 member 1	Homo sapiens	5-10
25666621-2	2015	In agreement with previous studies, resting pHi in cultured astrocytes was 6.82 +- 0.06 and inhibition of the V-ATPase H(+) pump by Cl(-) removal or via the selective inhibitor bafilomycin had only a small effect upon resting pHi and recovery following an acid load.	bafilomycin	177-188	glucose-6-phosphate isomerase	Rattus norvegicus	44-47
25666621-2	2015	In agreement with previous studies, resting pHi in cultured astrocytes was 6.82 +- 0.06 and inhibition of the V-ATPase H(+) pump by Cl(-) removal or via the selective inhibitor bafilomycin had only a small effect upon resting pHi and recovery following an acid load.	bafilomycin	177-188	glucose-6-phosphate isomerase	Rattus norvegicus	226-229
25766331-8	2015	Interestingly, inhibition of lysosomal activity by Bafilomycin A1 inhibits ST80/Bortezomib-stimulated IkappaBalpha degradation, NF-kappaB activation and BAG3 upregulation, indicating that IkappaBalpha is degraded via the lysosome in the presence of Bortezomib.	bafilomycin	51-62	NFKB inhibitor alpha	Homo sapiens	102-114
25766331-8	2015	Interestingly, inhibition of lysosomal activity by Bafilomycin A1 inhibits ST80/Bortezomib-stimulated IkappaBalpha degradation, NF-kappaB activation and BAG3 upregulation, indicating that IkappaBalpha is degraded via the lysosome in the presence of Bortezomib.	bafilomycin	51-62	nuclear factor kappa B subunit 1	Homo sapiens	128-137
25766331-8	2015	Interestingly, inhibition of lysosomal activity by Bafilomycin A1 inhibits ST80/Bortezomib-stimulated IkappaBalpha degradation, NF-kappaB activation and BAG3 upregulation, indicating that IkappaBalpha is degraded via the lysosome in the presence of Bortezomib.	bafilomycin	51-62	BAG cochaperone 3	Homo sapiens	153-157
25766331-8	2015	Interestingly, inhibition of lysosomal activity by Bafilomycin A1 inhibits ST80/Bortezomib-stimulated IkappaBalpha degradation, NF-kappaB activation and BAG3 upregulation, indicating that IkappaBalpha is degraded via the lysosome in the presence of Bortezomib.	bafilomycin	51-62	NFKB inhibitor alpha	Homo sapiens	188-200
25164368-6	2015	Upon inhibiting autophagy using bafilomycin we observed an increased level of palmitate-induced cell death assessed by Annexin V/PI staining, detection of active caspase-3 and MTT cell viability assay.	bafilomycin	32-43	annexin A5	Rattus norvegicus	119-128
25164368-6	2015	Upon inhibiting autophagy using bafilomycin we observed an increased level of palmitate-induced cell death assessed by Annexin V/PI staining, detection of active caspase-3 and MTT cell viability assay.	bafilomycin	32-43	caspase 3	Rattus norvegicus	162-171
25653352-6	2015	Bafilomycin A1 increased autophagosome number, LC3II, and SQSTM1 accumulation; Tat cotreatment diminished this effect.	bafilomycin	0-11	sequestosome 1	Homo sapiens	58-64
25653352-6	2015	Bafilomycin A1 increased autophagosome number, LC3II, and SQSTM1 accumulation; Tat cotreatment diminished this effect.	bafilomycin	0-11	tyrosine aminotransferase	Homo sapiens	79-82
25583996-5	2015	Moreover, in vivo disturbance of the pH gradient across membranes by bafilomycin A1 treatment caused Gls1 mislocalization.	bafilomycin	69-80	glutaminase	Homo sapiens	101-105
25451935-5	2015	The Ca(2+) transients induced in cells that overexpressed endosome-targeted hTPC1 were abolished upon depletion of acidic Ca(2+) stores by bafilomycin A1, but remained unaffected following depletion of endoplasmic reticulum stores by thapsigargin.	bafilomycin	139-150	two pore segment channel 1	Homo sapiens	76-81
26394653-7	2015	Autophagy inhibitors, 3-methyladenine (3-MA) and bafilomycin A1, enhanced TDT-induced cell death.	bafilomycin	49-60	DNA nucleotidylexotransferase	Homo sapiens	74-77
26156798-8	2015	We identified the ER-calcium ATPase Ca-P60A/dSERCA as a novel target of bafilomycin A1.	bafilomycin	72-83	Sarco/endoplasmic reticulum Ca(2+)-ATPase	Drosophila melanogaster	44-50
26176554-8	2015	Together these data indicate that HIV-1 Nef mimics Bafilomycin A1 and blocks the last step of autophagy thereby helping HIV-1 virus to avoid autophagic degradation in human astrocytes.	bafilomycin	51-62	Nef	Human immunodeficiency virus 1	40-43
25339765-4	2015	When GLUT1 was translocated into the plasma membrane from intracellular storage sites by bafilomycin A1 (BFLA1) treatment in 293T cells, HTLV-1 Env-mediated cell fusion and infection also were inhibited without the overexpression of GLUT1, indicating that the localization of GLUT1 in intracellular compartments rather than in the plasma membrane is crucial for the fusion activity of HTLV-1 Env.	bafilomycin	89-100	endogenous retrovirus group K member 20	Homo sapiens	144-147
25268952-3	2014	Here, we report that inhibition of proteasomal degradation with MG-132 and autophagy with bafilomycin A1 resulted in the release of IL-1beta but not that of IL-18 in human ARPE-19 cells.	bafilomycin	90-101	interleukin 1 beta	Homo sapiens	132-140
25268952-6	2014	Along with IL-1beta, exposure to MG-132 and bafilomycin A1 resulted in the secretion of IL-8.	bafilomycin	44-55	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
24847907-7	2014	Ang II (10(-7) mol/L, 48 h)-induced increase in the LC3-II to LC3-I ratio, the formation of autophagosomes, expression of beclin-1 and decrease in the expression of SQSTM1/p62 were also inhibited by pretreatment with 3-methyladenine or bafilomycin A1 (inhibitors of autophagy), olmesartan and candesartan (in dose-dependent manners), apocynin, 5HD, and siRNA Atg5.	bafilomycin	236-247	angiotensinogen	Rattus norvegicus	0-6
25096815-3	2014	Knockdown of CD81 and claudin-1, or treatment with bafilomycin A1, reduced infection in Huh-7 and Huh7.5.1 cells, suggesting that HCV entered both cell types via receptor-mediated, pH-dependent endocytosis.	bafilomycin	51-62	MIR7-3 host gene	Homo sapiens	88-93
24931141-7	2014	Notably, blocking of the autophagy pathway with bafilomycin resulted in a significant increase in inclusion formation in p.E121K TOR1A.	bafilomycin	48-59	torsin family 1 member A	Homo sapiens	129-134
24847907-7	2014	Ang II (10(-7) mol/L, 48 h)-induced increase in the LC3-II to LC3-I ratio, the formation of autophagosomes, expression of beclin-1 and decrease in the expression of SQSTM1/p62 were also inhibited by pretreatment with 3-methyladenine or bafilomycin A1 (inhibitors of autophagy), olmesartan and candesartan (in dose-dependent manners), apocynin, 5HD, and siRNA Atg5.	bafilomycin	236-247	sequestosome 1	Rattus norvegicus	165-171
24297483-7	2014	Furthermore, large amounts of phosphorylated MET that had accumulated in late endosomes were seen even after 60 min of HGF-stimulation in the presence of bafilomycin A1, indicating that degradation of phosphorylated MET proceeds in a late endosome/lysosome pathway.	bafilomycin	154-165	hepatocyte growth factor	Homo sapiens	119-122
24802400-8	2014	Moreover, inhibiting the induction of autophagy by treating cells with bafilomycin or a small interfering (si)RNA for ATG7 rescued Ad-PLD1-induced suppression of type I collagen accumulation in HSCs.	bafilomycin	71-82	phospholipase D1	Homo sapiens	134-138
24424055-7	2014	Abrogation of EDN1-enhanced H+ secretion by a vacuolar H+-ATPase inhibitor (bafilomycin A1) suggests that EDN1 exerts its action by regulating the H+-ATPase-mediated H+ secretion.	bafilomycin	76-87	endothelin 1	Danio rerio	14-18
24424055-7	2014	Abrogation of EDN1-enhanced H+ secretion by a vacuolar H+-ATPase inhibitor (bafilomycin A1) suggests that EDN1 exerts its action by regulating the H+-ATPase-mediated H+ secretion.	bafilomycin	76-87	endothelin 1	Danio rerio	106-110
24424509-0	2014	The (pro)renin receptor mediates constitutive PLZF-independent pro-proliferative effects which are inhibited by bafilomycin but not genistein.	bafilomycin	112-123	ATPase H+ transporting accessory protein 2	Homo sapiens	9-23
24424509-0	2014	The (pro)renin receptor mediates constitutive PLZF-independent pro-proliferative effects which are inhibited by bafilomycin but not genistein.	bafilomycin	112-123	zinc finger and BTB domain containing 16	Homo sapiens	46-50
24593782-3	2014	The V-ATPase activity (sensitive to 10(-7) mol L(-1) bafilomycin) from the cortical and outer medullary region was significantly stimulated by increasing the [Formula: see text] (outside Ca(2+)), in a dose-dependent pattern.	bafilomycin	53-64	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	4-12
24190489-5	2014	The levels of LC3 II expression we observed after co-treatment of PCBL with bafilomycin A1 and the reductions in p62 expression we observed after PCBL treatment in WiDr cells demonstrate increased autophagic flux, a reliable indicator of autophagic induction.	bafilomycin	76-87	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	14-17
24282227-10	2014	KH7 and bafilomycin A1, an inhibitor of H(+)-ATPase, both prevented the stimulatory effect of acetazolamide on pH recovery.	bafilomycin	8-19	ATPase H+ transporting V0 subunit a1	Homo sapiens	20-51
24359955-3	2014	Exposure of cultured cells to two drugs, the protein synthesis inhibitor cycloheximide and the V-ATPase inhibitor bafilomycin A1, recently showed that TfR is not only recycled back to the plasma membrane after endocytosis but is constitutively transported to lysosomes for degradation.	bafilomycin	114-125	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	95-103
24359955-3	2014	Exposure of cultured cells to two drugs, the protein synthesis inhibitor cycloheximide and the V-ATPase inhibitor bafilomycin A1, recently showed that TfR is not only recycled back to the plasma membrane after endocytosis but is constitutively transported to lysosomes for degradation.	bafilomycin	114-125	transferrin receptor	Mus musculus	151-154
24349058-6	2013	Treatment with the V-ATPase inhibitor, bafilomycin, reversed the inhibition of ER stress, secretion of apolipoprotein B, and hepatic lipid accumulation induced by EUE or its component, aucubin or geniposide.	bafilomycin	39-50	apolipoprotein B	Homo sapiens	103-119
23695424-5	2013	The early events in apoptosis analysed by Annexin V/PI staining indicated that the percentage of cells staining positive for Annexin V was slightly increased in SAS cells with tetrandrine treatment but was much lower following bafilomycin A1 pre-treatment.	bafilomycin	227-238	annexin A5	Homo sapiens	125-134
23838288-5	2013	Knock-down of CHOP by siRNA suppressed the cell death induced by bafilomycin A1 and tamoxifen, suggesting that bafilomycin A1-mediated CHOP activation sensitizes to tamoxifen.	bafilomycin	65-76	DNA damage inducible transcript 3	Homo sapiens	14-18
23838288-5	2013	Knock-down of CHOP by siRNA suppressed the cell death induced by bafilomycin A1 and tamoxifen, suggesting that bafilomycin A1-mediated CHOP activation sensitizes to tamoxifen.	bafilomycin	65-76	DNA damage inducible transcript 3	Homo sapiens	135-139
24606724-9	2014	Bafilomycin, a V-ATPase inhibitor, significantly decrease JH+.	bafilomycin	0-11	dynein axonemal heavy chain 8	Homo sapiens	17-23
24238063-7	2013	Inhibition of CD38 activity by nicotinamide or silencing of CD38 gene produced the similar effects to that bafilomycin A1 did in podocytes.	bafilomycin	107-118	CD38 antigen	Mus musculus	14-18
24238063-7	2013	Inhibition of CD38 activity by nicotinamide or silencing of CD38 gene produced the similar effects to that bafilomycin A1 did in podocytes.	bafilomycin	107-118	CD38 antigen	Mus musculus	60-64
24238063-9	2013	A colocalization of GFP-LC3B and RFP-Lamp1 upon stimulation of rapamycin became obvious in transfected podocytes, which could be substantially blocked by nicotinamide, CD38 shRNA, and bafilomycin.	bafilomycin	184-195	tripartite motif-containing 27	Mus musculus	33-36
24238063-9	2013	A colocalization of GFP-LC3B and RFP-Lamp1 upon stimulation of rapamycin became obvious in transfected podocytes, which could be substantially blocked by nicotinamide, CD38 shRNA, and bafilomycin.	bafilomycin	184-195	lysosomal-associated membrane protein 1	Mus musculus	37-42
24006492-4	2013	NHE5 depletion by plasmid-based short hairpin RNA significantly reduces cell surface abundance of TrkA, an effect similar to that observed after treatment with the V-ATPase inhibitor bafilomycin.	bafilomycin	183-194	solute carrier family 9 member A5	Rattus norvegicus	0-4
24006492-4	2013	NHE5 depletion by plasmid-based short hairpin RNA significantly reduces cell surface abundance of TrkA, an effect similar to that observed after treatment with the V-ATPase inhibitor bafilomycin.	bafilomycin	183-194	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	98-102
23698718-5	2013	In response to 2.5 mg/mL GA in INS-1 cells, autophagy induction and flux decreased as assessed by green fluorescent protein-microtubule-associated protein 1 light chain 3 dots, microtubule-associated protein 1 light chain 3-II conversion, and SQSTM1/p62 in the presence and absence of bafilomycin A1.	bafilomycin	285-296	glutaminase 2 (liver, mitochondrial)	Mus musculus	22-27
23695424-12	2013	Chloroquine, NAC and bafilomycin A1 also decreased tetrandrine-induced cleaved caspase-3 and cleaved PARP in SAS cells.	bafilomycin	21-32	poly(ADP-ribose) polymerase 1	Homo sapiens	101-105
23195496-7	2013	Autophagy inhibitors (e.g., 3-methylamphetamine and bafilomycin A1) or knockdown of ATG5 and beclin 1 blocked clinical grade IL-2-induced autophagy.	bafilomycin	52-63	interleukin 2	Mus musculus	125-129
23363291-7	2013	Treatment with melatonin counteracted the autophagy-inhibitory effects of bafilomycin A1, a potent inhibitor of autophagic flux, demonstrating that melatonin enhances activation of autophagy and increases degradation of TGFBIp.	bafilomycin	74-85	transforming growth factor beta induced	Homo sapiens	220-226
23818989-5	2013	In vivo ubiquitination assays demonstrated the ubiquitination of CFTR by MARCH2, and overexpression of MARCH2, like that of CAL and STX6, led to a dose-dependent degradation of mature CFTR that was blocked by bafilomycin A1 treatment.	bafilomycin	209-220	CF transmembrane conductance regulator	Homo sapiens	65-69
23818989-5	2013	In vivo ubiquitination assays demonstrated the ubiquitination of CFTR by MARCH2, and overexpression of MARCH2, like that of CAL and STX6, led to a dose-dependent degradation of mature CFTR that was blocked by bafilomycin A1 treatment.	bafilomycin	209-220	membrane associated ring-CH-type finger 2	Homo sapiens	103-109
23818989-5	2013	In vivo ubiquitination assays demonstrated the ubiquitination of CFTR by MARCH2, and overexpression of MARCH2, like that of CAL and STX6, led to a dose-dependent degradation of mature CFTR that was blocked by bafilomycin A1 treatment.	bafilomycin	209-220	golgi associated PDZ and coiled-coil motif containing	Homo sapiens	124-127
23818989-5	2013	In vivo ubiquitination assays demonstrated the ubiquitination of CFTR by MARCH2, and overexpression of MARCH2, like that of CAL and STX6, led to a dose-dependent degradation of mature CFTR that was blocked by bafilomycin A1 treatment.	bafilomycin	209-220	CF transmembrane conductance regulator	Homo sapiens	184-188
23457305-3	2013	Pharmacological inhibitors of lysosomal degradation, such as bafilomycin and chloroquine, increased HIF-1alpha levels and HIF-1 activity, whereas activators of chaperone-mediated autophagy, including 6-aminonicotinamide and nutrient starvation, decreased HIF-1alpha levels and HIF-1 activity.	bafilomycin	61-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-110
23457305-3	2013	Pharmacological inhibitors of lysosomal degradation, such as bafilomycin and chloroquine, increased HIF-1alpha levels and HIF-1 activity, whereas activators of chaperone-mediated autophagy, including 6-aminonicotinamide and nutrient starvation, decreased HIF-1alpha levels and HIF-1 activity.	bafilomycin	61-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-105
23457305-3	2013	Pharmacological inhibitors of lysosomal degradation, such as bafilomycin and chloroquine, increased HIF-1alpha levels and HIF-1 activity, whereas activators of chaperone-mediated autophagy, including 6-aminonicotinamide and nutrient starvation, decreased HIF-1alpha levels and HIF-1 activity.	bafilomycin	61-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	255-265
23457305-3	2013	Pharmacological inhibitors of lysosomal degradation, such as bafilomycin and chloroquine, increased HIF-1alpha levels and HIF-1 activity, whereas activators of chaperone-mediated autophagy, including 6-aminonicotinamide and nutrient starvation, decreased HIF-1alpha levels and HIF-1 activity.	bafilomycin	61-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	122-127
23137780-4	2013	2-APB also increased autophagic flux, indicated by heightened LC3II accumulation, which was further enhanced by bafilomycin (10nmol/L).	bafilomycin	112-123	arginyl aminopeptidase	Rattus norvegicus	2-5
23135267-10	2013	Knockdown of Mfrn2 in UMSCC22A cells decreased the rate of mitochondrial Fe(2+) uptake and delayed PDT plus bafilomycin-induced mitochondrial depolarization and cell killing.	bafilomycin	108-119	solute carrier family 25 member 28	Homo sapiens	13-18
23023870-10	2012	Shh further increased SMC LC3-II in the presence of bafilomycin A1, (2S,3S)-trans-epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester, and pepstatin A or siRNA for the autophagy-related gene 7 (ATG7).	bafilomycin	52-63	sonic hedgehog	Mus musculus	0-3
23011180-10	2012	Pre-treatment with the autophagy inhibitor Bafilomycin A1 caused caspase 3-mediated apoptosis in a DAPK-dependent manner.	bafilomycin	43-54	caspase 3	Homo sapiens	65-74
23011180-10	2012	Pre-treatment with the autophagy inhibitor Bafilomycin A1 caused caspase 3-mediated apoptosis in a DAPK-dependent manner.	bafilomycin	43-54	death associated protein kinase 1	Homo sapiens	99-103
22230367-5	2012	To examine the BI-1-associated P450 2E1 degradation mechanism, cells were treated with the lysosome inhibitor, bafilomycin and the proteasome inhibitor, MG132.	bafilomycin	111-122	transmembrane BAX inhibitor motif containing 6	Mus musculus	15-19
22689575-3	2012	Bafilomycin, an inhibitor of V-ATPase, inhibited EGF-stimulated DNA synthesis and mammalian target of rapamycin complex 1 (mTORC1) activation as indicated by a decrease in eukaryotic initiation factor 4E-binding 1 (4E-BP1) phosphorylation and p70 ribosomal S6 protein kinase (p70S6K) phosphorylation and kinase activity.	bafilomycin	0-11	epidermal growth factor	Homo sapiens	49-52
22689575-3	2012	Bafilomycin, an inhibitor of V-ATPase, inhibited EGF-stimulated DNA synthesis and mammalian target of rapamycin complex 1 (mTORC1) activation as indicated by a decrease in eukaryotic initiation factor 4E-binding 1 (4E-BP1) phosphorylation and p70 ribosomal S6 protein kinase (p70S6K) phosphorylation and kinase activity.	bafilomycin	0-11	mechanistic target of rapamycin kinase	Homo sapiens	82-111
22689575-3	2012	Bafilomycin, an inhibitor of V-ATPase, inhibited EGF-stimulated DNA synthesis and mammalian target of rapamycin complex 1 (mTORC1) activation as indicated by a decrease in eukaryotic initiation factor 4E-binding 1 (4E-BP1) phosphorylation and p70 ribosomal S6 protein kinase (p70S6K) phosphorylation and kinase activity.	bafilomycin	0-11	CREB regulated transcription coactivator 1	Mus musculus	123-129
22689575-3	2012	Bafilomycin, an inhibitor of V-ATPase, inhibited EGF-stimulated DNA synthesis and mammalian target of rapamycin complex 1 (mTORC1) activation as indicated by a decrease in eukaryotic initiation factor 4E-binding 1 (4E-BP1) phosphorylation and p70 ribosomal S6 protein kinase (p70S6K) phosphorylation and kinase activity.	bafilomycin	0-11	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	215-221
22689575-3	2012	Bafilomycin, an inhibitor of V-ATPase, inhibited EGF-stimulated DNA synthesis and mammalian target of rapamycin complex 1 (mTORC1) activation as indicated by a decrease in eukaryotic initiation factor 4E-binding 1 (4E-BP1) phosphorylation and p70 ribosomal S6 protein kinase (p70S6K) phosphorylation and kinase activity.	bafilomycin	0-11	ribosomal protein S6 kinase B1	Homo sapiens	243-274
22689575-3	2012	Bafilomycin, an inhibitor of V-ATPase, inhibited EGF-stimulated DNA synthesis and mammalian target of rapamycin complex 1 (mTORC1) activation as indicated by a decrease in eukaryotic initiation factor 4E-binding 1 (4E-BP1) phosphorylation and p70 ribosomal S6 protein kinase (p70S6K) phosphorylation and kinase activity.	bafilomycin	0-11	ribosomal protein S6 kinase B1	Homo sapiens	276-282
22689575-7	2012	Rather, the intracellular concentrations of essential but not non-essential amino acids were decreased by bafilomycin in EGF-treated primary rat hepatocytes.	bafilomycin	106-117	epidermal growth factor like 1	Rattus norvegicus	121-124
22302830-6	2012	OGG1 loss was inhibited by the autophagy inhibitor bafilomycin and in autophagy-deficient Atg5(-/-) mouse embryonic fibroblasts.	bafilomycin	51-62	8-oxoguanine DNA-glycosylase 1	Mus musculus	0-4
22187010-4	2012	Bafilomycin A1, an inhibitor of ER function, effectively blocked poly(I:C)-induced activation of caspase-8, -9, and -3, MnSOD and glutathione peroxidase 1 and reduced poly(I:C)-induced SK-N-AS apoptosis.	bafilomycin	0-11	caspase 8	Homo sapiens	97-118
22187010-4	2012	Bafilomycin A1, an inhibitor of ER function, effectively blocked poly(I:C)-induced activation of caspase-8, -9, and -3, MnSOD and glutathione peroxidase 1 and reduced poly(I:C)-induced SK-N-AS apoptosis.	bafilomycin	0-11	superoxide dismutase 2	Homo sapiens	120-125
22187010-4	2012	Bafilomycin A1, an inhibitor of ER function, effectively blocked poly(I:C)-induced activation of caspase-8, -9, and -3, MnSOD and glutathione peroxidase 1 and reduced poly(I:C)-induced SK-N-AS apoptosis.	bafilomycin	0-11	glutathione peroxidase 1	Homo sapiens	130-154
22878401-6	2012	Bafilomycin prevented the degradation of cargo and increased LC3-II and p62 in cytotrophoblasts exposed to hypoxia, revealing enhanced autophagic flux.	bafilomycin	0-11	nucleoporin 62	Homo sapiens	72-75
22878401-7	2012	Importantly, bafilomycin enhanced expression of autophagy-related protein 7 (Atg7), parallel to the increased apoptosis measured by cleaved poly(ADP-ribose) polymerase.	bafilomycin	13-24	autophagy related 7	Homo sapiens	48-75
22878401-7	2012	Importantly, bafilomycin enhanced expression of autophagy-related protein 7 (Atg7), parallel to the increased apoptosis measured by cleaved poly(ADP-ribose) polymerase.	bafilomycin	13-24	autophagy related 7	Homo sapiens	77-81
22878401-7	2012	Importantly, bafilomycin enhanced expression of autophagy-related protein 7 (Atg7), parallel to the increased apoptosis measured by cleaved poly(ADP-ribose) polymerase.	bafilomycin	13-24	poly(ADP-ribose) polymerase 1	Homo sapiens	140-167
22230367-6	2012	Bafilomycin recovered the reduced P450 2E1 expression in BI-1 cells, but did not affect P450 2E1 expression in Neo cells.	bafilomycin	0-11	transmembrane BAX inhibitor motif containing 6	Mus musculus	57-61
22349512-7	2012	Pretreatment with a lysosome inhibitor bafilomycin suppressed the degradation of c-kit, indicating that c-kit expression is controlled by SCF-induced endolysosomal degradation system.	bafilomycin	39-50	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	81-86
22349512-7	2012	Pretreatment with a lysosome inhibitor bafilomycin suppressed the degradation of c-kit, indicating that c-kit expression is controlled by SCF-induced endolysosomal degradation system.	bafilomycin	39-50	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	104-109
22349512-7	2012	Pretreatment with a lysosome inhibitor bafilomycin suppressed the degradation of c-kit, indicating that c-kit expression is controlled by SCF-induced endolysosomal degradation system.	bafilomycin	39-50	KIT ligand	Homo sapiens	138-141
23097745-8	2012	These studies suggest that the membrane sorting process of hOST is mediated by a bafilomycin A1-sensitive vesicular pathway that is associated with the actin-cytoskeleton network.	bafilomycin	81-92	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	59-63
21722633-7	2011	We also showed that pretreatment of fibroblasts with bafilomycin resulted in a GBF1-independent BFA resistance that appears additive with the resistance associated with COG deficiency.	bafilomycin	53-64	golgi brefeldin A resistant guanine nucleotide exchange factor 1	Bos taurus	79-83
22880058-3	2012	In the presence of bafilomycin, which inhibits vacuolar ATPase and consequently the acidification of endosomal compartments, CD1e associates with a 27 kD protein.	bafilomycin	19-30	CD1e molecule	Homo sapiens	125-129
22880058-6	2012	The quantity of LAPTM5/CD1e complexes increases when the cells are treated with bafilomycin, probably due to the protection of LAPTM5 from lysosomal proteases.	bafilomycin	80-91	lysosomal protein transmembrane 5	Homo sapiens	16-22
22880058-6	2012	The quantity of LAPTM5/CD1e complexes increases when the cells are treated with bafilomycin, probably due to the protection of LAPTM5 from lysosomal proteases.	bafilomycin	80-91	CD1e molecule	Homo sapiens	23-27
22880058-6	2012	The quantity of LAPTM5/CD1e complexes increases when the cells are treated with bafilomycin, probably due to the protection of LAPTM5 from lysosomal proteases.	bafilomycin	80-91	lysosomal protein transmembrane 5	Homo sapiens	127-133
21910808-8	2011	The Rab5a cycle was destabilized by microtubule depolymerization and by bafilomycin A1.	bafilomycin	72-83	RAB5A, member RAS oncogene family	Mus musculus	4-9
21067284-2	2011	Under GSH-depleted conditions, H2O2-induced autophagic cell, characterized by an increased LC3-II/I ratio, a decreased level of p62 and the formation of autophagic vacuoles, was inhibited by bafilomycin A1 and by Atg5 siRNA transfection, whereas the cell death was not inhibited by zVAD-fmk, by PI3K inhibitors or by Beclin 1 siRNA transfection.	bafilomycin	191-202	nucleoporin 62	Mus musculus	128-131
21558123-6	2011	Chromaffin granule pH, monitored by fluorescence of CHGA/EGFP chimera during vesicular H(+)-ATPase inhibition by bafilomycin A1, was more easily perturbed during coexpression of the ATP6V0A1 3"-UTR C-allele than the T-allele.	bafilomycin	113-124	chromogranin A	Homo sapiens	52-56
21558123-6	2011	Chromaffin granule pH, monitored by fluorescence of CHGA/EGFP chimera during vesicular H(+)-ATPase inhibition by bafilomycin A1, was more easily perturbed during coexpression of the ATP6V0A1 3"-UTR C-allele than the T-allele.	bafilomycin	113-124	ATPase H+ transporting V0 subunit a1	Homo sapiens	182-190
21515589-7	2011	There was increased expression of sqstm1, autophagy-related gene 5 (atg5) and light chain 3 gene (lc3) in osteoclast precursors and increased LC3-II protein levels in Bafilomycin-treated osteoclasts from P394L mutant mice compared with wild-type suggesting dysregulation of autophagy and enhanced autophagosome formation.	bafilomycin	167-178	sequestosome 1	Mus musculus	34-40
21515589-7	2011	There was increased expression of sqstm1, autophagy-related gene 5 (atg5) and light chain 3 gene (lc3) in osteoclast precursors and increased LC3-II protein levels in Bafilomycin-treated osteoclasts from P394L mutant mice compared with wild-type suggesting dysregulation of autophagy and enhanced autophagosome formation.	bafilomycin	167-178	autophagy related 5	Mus musculus	68-72
21515589-7	2011	There was increased expression of sqstm1, autophagy-related gene 5 (atg5) and light chain 3 gene (lc3) in osteoclast precursors and increased LC3-II protein levels in Bafilomycin-treated osteoclasts from P394L mutant mice compared with wild-type suggesting dysregulation of autophagy and enhanced autophagosome formation.	bafilomycin	167-178	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	98-101
21515589-7	2011	There was increased expression of sqstm1, autophagy-related gene 5 (atg5) and light chain 3 gene (lc3) in osteoclast precursors and increased LC3-II protein levels in Bafilomycin-treated osteoclasts from P394L mutant mice compared with wild-type suggesting dysregulation of autophagy and enhanced autophagosome formation.	bafilomycin	167-178	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	142-145
21586565-7	2011	Bafilomycin, a V-ATPase inhibitor, leads to the reversal of BI-1-induced regulation of ER stress response and cell death due to ER stress.	bafilomycin	0-11	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	15-23
21586565-7	2011	Bafilomycin, a V-ATPase inhibitor, leads to the reversal of BI-1-induced regulation of ER stress response and cell death due to ER stress.	bafilomycin	0-11	transmembrane BAX inhibitor motif containing 6	Mus musculus	60-64
21525007-7	2011	Loss of Mek1/2 kinase activity reduces SR-BI expression in the presence of bafilomycin, an inhibitor of lysosomal degradation, indicating down-regulation of SR-BI via proteasomal pathways.	bafilomycin	75-86	mitogen-activated protein kinase kinase 1	Homo sapiens	8-14
21525007-7	2011	Loss of Mek1/2 kinase activity reduces SR-BI expression in the presence of bafilomycin, an inhibitor of lysosomal degradation, indicating down-regulation of SR-BI via proteasomal pathways.	bafilomycin	75-86	scavenger receptor class B member 1	Homo sapiens	39-44
21525007-7	2011	Loss of Mek1/2 kinase activity reduces SR-BI expression in the presence of bafilomycin, an inhibitor of lysosomal degradation, indicating down-regulation of SR-BI via proteasomal pathways.	bafilomycin	75-86	scavenger receptor class B member 1	Homo sapiens	157-162
21272169-5	2011	Unexpectedly, cells depleted of securin or separase display defective acidification of early endosomes and increased membrane recruitment of vacuolar (V-) ATPase complexes, mimicking the effect of the specific V-ATPase inhibitor Bafilomycin A1.	bafilomycin	229-240	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	32-39
21272169-5	2011	Unexpectedly, cells depleted of securin or separase display defective acidification of early endosomes and increased membrane recruitment of vacuolar (V-) ATPase complexes, mimicking the effect of the specific V-ATPase inhibitor Bafilomycin A1.	bafilomycin	229-240	extra spindle pole bodies like 1, separase	Homo sapiens	43-51
21067284-2	2011	Under GSH-depleted conditions, H2O2-induced autophagic cell, characterized by an increased LC3-II/I ratio, a decreased level of p62 and the formation of autophagic vacuoles, was inhibited by bafilomycin A1 and by Atg5 siRNA transfection, whereas the cell death was not inhibited by zVAD-fmk, by PI3K inhibitors or by Beclin 1 siRNA transfection.	bafilomycin	191-202	autophagy related 5	Mus musculus	213-217
21067284-2	2011	Under GSH-depleted conditions, H2O2-induced autophagic cell, characterized by an increased LC3-II/I ratio, a decreased level of p62 and the formation of autophagic vacuoles, was inhibited by bafilomycin A1 and by Atg5 siRNA transfection, whereas the cell death was not inhibited by zVAD-fmk, by PI3K inhibitors or by Beclin 1 siRNA transfection.	bafilomycin	191-202	beclin 1, autophagy related	Mus musculus	317-325
20980833-7	2011	Autophagy inhibitors bafilomycin and chloroquine significantly increased the cytotoxicity of compound C towards U251 cells, as confirmed by increase in lactate dehydrogenase release, DNA fragmentation and caspase-3 activation.	bafilomycin	21-32	caspase 3	Homo sapiens	205-214
20534000-4	2010	Bafilomycin also attenuated the chloroquine-induced reduction in processing of cathepsin D, the principal lysosomal aspartic acid protease, to its mature "active" form.	bafilomycin	0-11	cathepsin D	Homo sapiens	79-90
20732383-9	2011	Lactacystin, a proteasome inhibitor, and bafilomycin A1, a lysosomal protease inhibitor, significantly restored the suppressive effect of Wnt3a on TNF-alpha-stimulated IL-6 release.	bafilomycin	41-52	wingless-type MMTV integration site family, member 3A	Mus musculus	138-143
20732383-9	2011	Lactacystin, a proteasome inhibitor, and bafilomycin A1, a lysosomal protease inhibitor, significantly restored the suppressive effect of Wnt3a on TNF-alpha-stimulated IL-6 release.	bafilomycin	41-52	tumor necrosis factor	Mus musculus	147-156
20732383-9	2011	Lactacystin, a proteasome inhibitor, and bafilomycin A1, a lysosomal protease inhibitor, significantly restored the suppressive effect of Wnt3a on TNF-alpha-stimulated IL-6 release.	bafilomycin	41-52	interleukin 6	Mus musculus	168-172
21172612-4	2010	Blocking H(+) pumping by vesicular H(+)-ATPase (with folimycin or bafilomycin) suppresses stimulation-induced alkalinization and reduces endocytotic uptake of FM1-43.	bafilomycin	66-77	dynein, axonemal, heavy chain 8	Mus musculus	40-46
20926783-3	2010	Hypotonicity-triggered bCE ATP release was inhibited by the relatively selective blocker of pannexin-1 (PX1) hemichannels (probenecid, 1 mM, 47 +- 2%), by a connexin inhibitor (heptanol, 1 mM, 49 +- 4%), and by an inhibitor of vesicular release (bafilomycin A1, 25 +- 2%), but not by the P2X(7) receptor (P2RX(7)) antagonist KN-62.	bafilomycin	246-257	pannexin 1	Bos taurus	92-102
20926783-3	2010	Hypotonicity-triggered bCE ATP release was inhibited by the relatively selective blocker of pannexin-1 (PX1) hemichannels (probenecid, 1 mM, 47 +- 2%), by a connexin inhibitor (heptanol, 1 mM, 49 +- 4%), and by an inhibitor of vesicular release (bafilomycin A1, 25 +- 2%), but not by the P2X(7) receptor (P2RX(7)) antagonist KN-62.	bafilomycin	246-257	pannexin 1	Bos taurus	104-107
20876534-5	2010	In contrast, Ca(2+) signals in response to thrombin are only partially inhibited by bafilomycin A1 treatment, and those to ATP were insensitive, suggesting that recruitment of acidic stores is agonist-specific.	bafilomycin	84-95	coagulation factor II	Rattus norvegicus	43-51
20876581-9	2010	Bafilomycin A1, but not MG132, blocked TGF-beta1 down-regulation of p27, suggesting that p27 levels were regulated through autophagy.	bafilomycin	0-11	transforming growth factor, beta 1	Mus musculus	39-48
20876581-9	2010	Bafilomycin A1, but not MG132, blocked TGF-beta1 down-regulation of p27, suggesting that p27 levels were regulated through autophagy.	bafilomycin	0-11	cyclin-dependent kinase inhibitor 1B	Mus musculus	68-71
20876581-9	2010	Bafilomycin A1, but not MG132, blocked TGF-beta1 down-regulation of p27, suggesting that p27 levels were regulated through autophagy.	bafilomycin	0-11	cyclin-dependent kinase inhibitor 1B	Mus musculus	89-92
20937257-6	2010	Treatment with the vacuolar ATPase inhibitor bafilomycin led to increased persistence of ERK1/2 phosphorylation in response to aggregated IgG.	bafilomycin	45-56	mitogen-activated protein kinase 3	Homo sapiens	89-95
20796177-1	2010	We examined the effect of concanamycin A and bafilomycin A1, inhibitors of the vacuolar proton-ATPase, on maturation and expression of Ret, a tyrosine kinase receptor for glial cell line-derived neurotrophic factor.	bafilomycin	45-56	ret proto-oncogene	Homo sapiens	135-138
20944112-10	2010	Treatment with autophagy inhibitor bafilomycin A1 (but not 3-methyladenine) with SFN significantly enhanced apoptosis, which was accompanied by increases in the level of BAX and the cleavage of caspase-3 and poly(ADP-ribose)polymerase (PARP)-1 and decreases in the mitochondrial membrane potential (DeltaPsim).	bafilomycin	35-46	BCL2 associated X, apoptosis regulator	Homo sapiens	170-173
20944112-10	2010	Treatment with autophagy inhibitor bafilomycin A1 (but not 3-methyladenine) with SFN significantly enhanced apoptosis, which was accompanied by increases in the level of BAX and the cleavage of caspase-3 and poly(ADP-ribose)polymerase (PARP)-1 and decreases in the mitochondrial membrane potential (DeltaPsim).	bafilomycin	35-46	caspase 3	Homo sapiens	194-203
20944112-10	2010	Treatment with autophagy inhibitor bafilomycin A1 (but not 3-methyladenine) with SFN significantly enhanced apoptosis, which was accompanied by increases in the level of BAX and the cleavage of caspase-3 and poly(ADP-ribose)polymerase (PARP)-1 and decreases in the mitochondrial membrane potential (DeltaPsim).	bafilomycin	35-46	poly(ADP-ribose) polymerase 1	Homo sapiens	208-243
20609358-11	2010	The effect of AICAR on pH(i) and DeltapH(i) was blunted in the presence of the Na(+)/H(+) exchanger inhibitor cariporide (10microM), but not by the H(+) ATPase inhibitor bafilomycin (10nM).	bafilomycin	170-181	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	14-19
20886049-9	2010	Serum starvation as an inducer of autophagy caused marked BAMBI degradation, which could be totally prevented by inhibition of lysosomal and autolysosomal degradation with bafilomycin, and partially by inhibition of autophagy with 3-methyladenine, but not by proteasomal inhibitors.	bafilomycin	172-183	BMP and activin membrane-bound inhibitor	Mus musculus	58-63
20541008-6	2010	Co-incubation with bafilomycin A1 (10 nM) further increased hypoxia-induced LC3-II levels but 3-methyladenine (3-MA; 10 mM) reduced the elevation in LC3-II levels induced by 8-h hypoxia.	bafilomycin	19-30	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	76-79
20534000-6	2010	In addition, bafilomycin significantly and dose-dependently attenuated dopaminergic neuron death in C. elegans resulting from in vivo over-expression of human wild-type alpha-synuclein.	bafilomycin	13-24	synuclein alpha	Homo sapiens	169-184
20624974-6	2010	L-vesamicol and bafilomycin blocked the actions of TGF-beta2, indicating that TGF-beta2 acts by altering the extent of vesicular filling.	bafilomycin	16-27	transforming growth factor, beta 2	Rattus norvegicus	51-60
19439521-7	2009	Vacuolar H(+)-ATPase inhibitors bafilomycin A1 and concanamycin A, disruptors of pH and Ca(2+) stores of lysosomes and other acidic organelles, individually antagonized [Ca(2+)](i) responses to ET-1 and NE by 40-50% (P < 0.05).	bafilomycin	32-43	endothelin 1	Rattus norvegicus	194-198
20421284-8	2010	Overexpression of CLC-5 in HEK293 cells conferred an additional bafilomycin-insensitive component to endosomal acidification.	bafilomycin	64-75	chloride voltage-gated channel 5	Homo sapiens	18-23
20411394-10	2010	In cells from bestrophin-1-deficient mice, ATP-dependent increase in [Ca(2+)](i) resulted in 40% of cells from depletion of bafilomycin-sensitive and in 60% from thapsigargin-sensitive Ca(2+) stores.	bafilomycin	124-135	bestrophin 1	Mus musculus	14-26
20018950-4	2010	Moreover, NAADP-evoked calcium signals via TPC2 are ablated by short hairpin RNA knockdown of TPC2 and by depletion of acidic calcium stores with bafilomycin.	bafilomycin	146-157	two pore segment channel 2	Homo sapiens	43-47
19610106-7	2010	Water channels are bidirectional and the vH(+)-ATPase inhibitor bafilomycin decreases both the volume of isolated synaptic vesicles and GTP-mastoparan stimulated swelling, suggesting that vH(+)-ATPase is upstream of AQP-6, in the pathway leading from G(alphao)-stimulated swelling of synaptic vesicles.	bafilomycin	64-75	aquaporin 6	Homo sapiens	216-221
20680098-12	2010	The silencing of p62, rather than Hsp70, evoked suppression of autophagy, when related to decreased LC3-II levels after bafilomycin treatment.	bafilomycin	120-131	sequestosome 1	Homo sapiens	17-20
20371669-5	2010	Autophagy blocking by 3-methyladenine (3MA) or bafilomycin A1 (BaF1) activated caspase-4 and -7 and enhanced cell death.	bafilomycin	47-58	caspase 4	Homo sapiens	79-95
20102634-6	2010	Moreover, the Vpu-mediated decrease of GaLV Env levels was inhibited by the lysosomal inhibitor, bafilomycin A1.	bafilomycin	97-108	Vpu	Human immunodeficiency virus 1	14-17
20102634-6	2010	Moreover, the Vpu-mediated decrease of GaLV Env levels was inhibited by the lysosomal inhibitor, bafilomycin A1.	bafilomycin	97-108	hypothetical protein	Gibbon ape leukemia virus	44-47
19400951-11	2009	Treatment of vector control K562 cells with the autophagy inhibitors 3-methyladenine and bafilomycin A1 recapitulated the growth kinetics, vacuolar morphology and LC3-II accumulation of CSN2 knockdown cells indicating that the cellular phenotype of CSN2 cells arises from autophagy inhibition.	bafilomycin	89-100	casein beta	Homo sapiens	186-190
19242516-8	2009	LC incubation in the presence of bafilomycin completely reversed the effect of poly(I:C) on LC phenotypic activation and survival, indicating that endosomal TLR3 is involved in this process.	bafilomycin	33-44	toll like receptor 3	Homo sapiens	157-161
18988918-8	2009	Bafilomycin, an inhibitor of TLR3 signaling, diminished poly(I:C)-augmented TGF-beta(1) release.	bafilomycin	0-11	toll like receptor 3	Homo sapiens	29-33
18988918-8	2009	Bafilomycin, an inhibitor of TLR3 signaling, diminished poly(I:C)-augmented TGF-beta(1) release.	bafilomycin	0-11	transforming growth factor beta 1	Homo sapiens	76-87
19478868-9	2009	The decreases in cell-surface and intracellular BST-2 are inhibited by bafilomycin A1, an inhibitor of endosomal acidification; these data suggest that Vpu induces late endosomal targeting and partial degradation of BST-2 in lysosomes.	bafilomycin	71-82	bone marrow stromal cell antigen 2	Homo sapiens	48-53
19478868-9	2009	The decreases in cell-surface and intracellular BST-2 are inhibited by bafilomycin A1, an inhibitor of endosomal acidification; these data suggest that Vpu induces late endosomal targeting and partial degradation of BST-2 in lysosomes.	bafilomycin	71-82	Vpu	Human immunodeficiency virus 1	152-155
19478868-9	2009	The decreases in cell-surface and intracellular BST-2 are inhibited by bafilomycin A1, an inhibitor of endosomal acidification; these data suggest that Vpu induces late endosomal targeting and partial degradation of BST-2 in lysosomes.	bafilomycin	71-82	bone marrow stromal cell antigen 2	Homo sapiens	216-221
19400951-11	2009	Treatment of vector control K562 cells with the autophagy inhibitors 3-methyladenine and bafilomycin A1 recapitulated the growth kinetics, vacuolar morphology and LC3-II accumulation of CSN2 knockdown cells indicating that the cellular phenotype of CSN2 cells arises from autophagy inhibition.	bafilomycin	89-100	casein beta	Homo sapiens	249-253
18927491-11	2008	Bafilomycin and leupeptin, inhibitors of lysosomes, prevented HIF-1alpha decrease without affecting LC3 processing.	bafilomycin	0-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-72
18772496-6	2008	In the presence of lysosome function inhibitors, bafilomycin (Baf) or glycyl-L-phenylalanine-beta-naphthylamide (GPN), these FasL-induced changes were abolished.	bafilomycin	49-60	Fas ligand	Homo sapiens	125-129
18486461-6	2008	Bafilomycin exposure also inactivated the insulin/IGF signaling pathway intermediate, FoxO1, and increased the insulin content in neonatal islets.	bafilomycin	0-11	forkhead box O1	Mus musculus	86-91
18632865-3	2008	The entry of ENTV Env pseudovirions was substantially inhibited by bafilomycin A1 (BafA1) but was surprisingly enhanced by lysosomotropic agents and lysosomal protease inhibitors following a 4- to 6-h treatment period; of note, prolonged treatment with BafA1 or ammonium chloride completely blocked ENTV entry.	bafilomycin	67-78	envelope protein	Jaagsiekte sheep retrovirus	18-21
18434619-4	2008	Rather, hypoxia and LPS reduced the intracellular levels of TNF-alpha by twofold (P < 0.01) by enhancing its degradation in the lysosomes and inhibiting its secretion via secretory lysosomes, as shown by confocal microscopy and verified by the use of the lysosome inhibitor Bafilomycin A1.	bafilomycin	277-288	toll-like receptor 4	Mus musculus	20-23
18434619-4	2008	Rather, hypoxia and LPS reduced the intracellular levels of TNF-alpha by twofold (P < 0.01) by enhancing its degradation in the lysosomes and inhibiting its secretion via secretory lysosomes, as shown by confocal microscopy and verified by the use of the lysosome inhibitor Bafilomycin A1.	bafilomycin	277-288	tumor necrosis factor	Mus musculus	60-69
18034775-4	2008	Here, we demonstrated that stimulation of EphB1 with ephrinB1/Fc led to a marked downregulation of EphB1 protein, a process blocked by the lysosomal inhibitor bafilomycin.	bafilomycin	159-170	EPH receptor B1	Homo sapiens	42-47
18216495-7	2008	Chloroquine also enhanced the accumulation of autophagosomes in cells stimulated with hydrogen peroxide, while it attenuated that induced by Bafilomycin A1, an inhibitor of V-ATPase that interferes with fusion of autophagosomes with lysosomes.	bafilomycin	141-152	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	173-181
17641954-4	2008	Both brefeldin A (a Golgi complex disruptor) and bafilomycin A1 (an inhibitor of vacuolar H+-ATPase) treatment significantly decreased the polarized membrane trafficking and markedly reduced the uptake of estrone-3-sulfate ( approximately 40-90%) in OATPC-GFP transfected cells, suggesting that membrane sorting of hOATPC-GFP was mediated by Golgi complex and vacuolar H+-ATPase-related vesicle transport pathways.	bafilomycin	49-60	solute carrier organic anion transporter family member 1B1	Homo sapiens	250-255
17641954-4	2008	Both brefeldin A (a Golgi complex disruptor) and bafilomycin A1 (an inhibitor of vacuolar H+-ATPase) treatment significantly decreased the polarized membrane trafficking and markedly reduced the uptake of estrone-3-sulfate ( approximately 40-90%) in OATPC-GFP transfected cells, suggesting that membrane sorting of hOATPC-GFP was mediated by Golgi complex and vacuolar H+-ATPase-related vesicle transport pathways.	bafilomycin	49-60	solute carrier organic anion transporter family member 1B1	Homo sapiens	315-321
18576347-7	2008	IFNalpha induction was inhibited by anti-blood dendritic cell antigen 2 (90%), anti-CD32 (76%), bafilomycin (99%), and RNase (82%).	bafilomycin	96-107	interferon alpha 1	Homo sapiens	0-8
17712531-8	2008	Consistent with this, when the acidification of endosomes is prevented by bafilomycin then heme oxygenase-1 induction by heme-HPX no longer occurs.	bafilomycin	74-85	heme oxygenase 1	Homo sapiens	91-107
18430083-8	2008	Similar effects on lysosomal morphology and TLF sensitivity were also obtained by two pharmacological agents that neutralize lysosomal pH--chloroquine and bafilomycin A1.	bafilomycin	155-166	TATA-box binding protein like 1	Homo sapiens	44-47
18034775-4	2008	Here, we demonstrated that stimulation of EphB1 with ephrinB1/Fc led to a marked downregulation of EphB1 protein, a process blocked by the lysosomal inhibitor bafilomycin.	bafilomycin	159-170	ephrin B1	Homo sapiens	53-61
18034775-4	2008	Here, we demonstrated that stimulation of EphB1 with ephrinB1/Fc led to a marked downregulation of EphB1 protein, a process blocked by the lysosomal inhibitor bafilomycin.	bafilomycin	159-170	EPH receptor B1	Homo sapiens	99-104
18045865-5	2008	Bafilomycin or 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid disodium salt largely abolished the CD95L-induced endosomal acidification, ceramide formation, and downstream events, such as p47(phox) phosphorylation, ROS formation, CD95 activation, and apoptosis.	bafilomycin	0-11	Fas ligand	Rattus norvegicus	100-105
18045865-5	2008	Bafilomycin or 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid disodium salt largely abolished the CD95L-induced endosomal acidification, ceramide formation, and downstream events, such as p47(phox) phosphorylation, ROS formation, CD95 activation, and apoptosis.	bafilomycin	0-11	NSFL1 cofactor	Rattus norvegicus	190-193
17005267-0	2006	Bafilomycin A1-sensitive pathway is required for the maturation of cystic fibrosis transmembrane conductance regulator.	bafilomycin	0-11	CF transmembrane conductance regulator	Homo sapiens	67-118
17904536-7	2007	Stimulation of the nerve in the presence of bafilomycin, the blocker of the transmitter uptake, produced significantly stronger depression in Syn KO boutons.	bafilomycin	44-55	Synapsin	Drosophila melanogaster	142-145
17239604-0	2007	The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling.	bafilomycin	30-41	Wnt family member 1	Homo sapiens	77-80
17239604-3	2007	Here we report that bafilomycin, a specific inhibitor of the vacuolar proton ATPase that blocks endosomal acidification, inhibits canonical Wnt signal transduction initiated by Wnt ligand and partially inhibits signaling initiated by disheveled.	bafilomycin	20-31	Wnt family member 1	Homo sapiens	140-143
17239604-3	2007	Here we report that bafilomycin, a specific inhibitor of the vacuolar proton ATPase that blocks endosomal acidification, inhibits canonical Wnt signal transduction initiated by Wnt ligand and partially inhibits signaling initiated by disheveled.	bafilomycin	20-31	Wnt family member 1	Homo sapiens	177-180
17178925-0	2007	ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1alpha (HIF-1alpha) binding and mediates HIF-1alpha expression by bafilomycin A1.	bafilomycin	142-153	ATPase H+ transporting V0 subunit c	Homo sapiens	0-7
17178925-0	2007	ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1alpha (HIF-1alpha) binding and mediates HIF-1alpha expression by bafilomycin A1.	bafilomycin	142-153	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-82
17178925-0	2007	ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1alpha (HIF-1alpha) binding and mediates HIF-1alpha expression by bafilomycin A1.	bafilomycin	142-153	hypoxia inducible factor 1 subunit alpha	Homo sapiens	84-94
17178925-0	2007	ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1alpha (HIF-1alpha) binding and mediates HIF-1alpha expression by bafilomycin A1.	bafilomycin	142-153	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-127
17178925-3	2007	We recently reported that bafilomycin A1 exorbitantly expressed HIF-1alpha and induced the p21(WAF1/Cip1)-mediated growth arrest of tumors (Mol Pharmacol 70:1856-1865, 2006).	bafilomycin	26-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-74
17178925-3	2007	We recently reported that bafilomycin A1 exorbitantly expressed HIF-1alpha and induced the p21(WAF1/Cip1)-mediated growth arrest of tumors (Mol Pharmacol 70:1856-1865, 2006).	bafilomycin	26-37	cyclin dependent kinase inhibitor 1A	Homo sapiens	91-94
17178925-3	2007	We recently reported that bafilomycin A1 exorbitantly expressed HIF-1alpha and induced the p21(WAF1/Cip1)-mediated growth arrest of tumors (Mol Pharmacol 70:1856-1865, 2006).	bafilomycin	26-37	cyclin dependent kinase inhibitor 1A	Homo sapiens	95-99
17178925-3	2007	We recently reported that bafilomycin A1 exorbitantly expressed HIF-1alpha and induced the p21(WAF1/Cip1)-mediated growth arrest of tumors (Mol Pharmacol 70:1856-1865, 2006).	bafilomycin	26-37	cyclin dependent kinase inhibitor 1A	Homo sapiens	100-104
17178925-4	2007	In the present study, we addressed the mechanism underlying bafilomycin-induced HIF-1alpha expression.	bafilomycin	60-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90
17178925-5	2007	Bafilomycin stabilized HIF-1alpha under normoxic conditions without changes in intracellular pH.	bafilomycin	0-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-33
17178925-6	2007	However, when ATP6V0C, the target protein of bafilomycin, was knocked down, this bafilomycin effect was significantly attenuated.	bafilomycin	45-56	ATPase H+ transporting V0 subunit c	Homo sapiens	14-21
17178925-6	2007	However, when ATP6V0C, the target protein of bafilomycin, was knocked down, this bafilomycin effect was significantly attenuated.	bafilomycin	81-92	ATPase H+ transporting V0 subunit c	Homo sapiens	14-21
17178925-8	2007	ATP6V0C competed with Von Hippel-Lindau protein in HIF-1alpha binding by directly interacting with HIF-1alpha, which was stimulated by bafilomycin.	bafilomycin	135-146	ATPase H+ transporting V0 subunit c	Homo sapiens	0-7
17178925-8	2007	ATP6V0C competed with Von Hippel-Lindau protein in HIF-1alpha binding by directly interacting with HIF-1alpha, which was stimulated by bafilomycin.	bafilomycin	135-146	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-61
18086377-5	2007	Utilization of the vacuolar ATPase inhibitor bafilomycin indicates that a fourth of the approximately 200nM N(2)O(3)/h sustained by IFNgamma-primed macrophages is generated in endosomal compartments via condensation of HNO(2).	bafilomycin	45-56	interferon gamma	Homo sapiens	132-140
16940187-0	2006	Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1alpha.	bafilomycin	0-11	H3 histone pseudogene 16	Homo sapiens	24-27
16940187-0	2006	Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1alpha.	bafilomycin	0-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-141
16940187-4	2006	In the present study, we tested the possibility that bafilomycin targets a tumor-promoting factor, hypoxia-inducible factor-1alpha (HIF-1alpha).	bafilomycin	53-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-130
16940187-4	2006	In the present study, we tested the possibility that bafilomycin targets a tumor-promoting factor, hypoxia-inducible factor-1alpha (HIF-1alpha).	bafilomycin	53-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	132-142
16940187-5	2006	Bafilomycin A1 and its analog, concanamycin A, were found to up-regulate HIF-1alpha in eight human cancer cell-lines, and this effect is attributed to inhibited degradation of HIF-1alpha protein.	bafilomycin	0-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-83
16940187-5	2006	Bafilomycin A1 and its analog, concanamycin A, were found to up-regulate HIF-1alpha in eight human cancer cell-lines, and this effect is attributed to inhibited degradation of HIF-1alpha protein.	bafilomycin	0-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	176-186
16940187-6	2006	Furthermore, the HIF-1alpha induction by bafilomycin was augmented by hypoxia, which caused a robust induction of p21 and cell cycle arrest in cancer cells.	bafilomycin	41-52	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27
16940187-6	2006	Furthermore, the HIF-1alpha induction by bafilomycin was augmented by hypoxia, which caused a robust induction of p21 and cell cycle arrest in cancer cells.	bafilomycin	41-52	H3 histone pseudogene 16	Homo sapiens	114-117
16940187-8	2006	In HIF-1alpha(+/+) or HIF-1alpha(-/-) fibrosarcomas grafted in nude mice, bafilomycin showed the HIF-1alpha-dependent anticancer effect.	bafilomycin	74-85	hypoxia inducible factor 1, alpha subunit	Mus musculus	3-13
16940187-8	2006	In HIF-1alpha(+/+) or HIF-1alpha(-/-) fibrosarcomas grafted in nude mice, bafilomycin showed the HIF-1alpha-dependent anticancer effect.	bafilomycin	74-85	hypoxia inducible factor 1, alpha subunit	Mus musculus	22-32
16940187-8	2006	In HIF-1alpha(+/+) or HIF-1alpha(-/-) fibrosarcomas grafted in nude mice, bafilomycin showed the HIF-1alpha-dependent anticancer effect.	bafilomycin	74-85	hypoxia inducible factor 1, alpha subunit	Mus musculus	22-32
16940187-9	2006	Based on these results, the exorbitant expression of HIF-1alpha is likely to contribute to the anticancer action of bafilomycin.	bafilomycin	116-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-63
16769263-14	2006	Finally, bafilomycin A1, an inhibitor of the vacuolar H+-ATPase, reversed the hyperalgesia and down-regulated ASIC1a mRNA expression in the DRGs.	bafilomycin	9-20	acid-sensing (proton-gated) ion channel 1	Mus musculus	110-116
16895977-1	2006	In the mouse leukemic monocyte cell line RAW 264.7, the vacuolar-type (H(+))-ATPase (V-ATPase) inhibitors bafilomycin A1 and concanamycin A induced nitric oxide (NO) production through the expression of inducible nitric-oxide synthase mRNA and its protein and decreased cell growth and survival as determined by 3-(4,5-dimethyl(thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.	bafilomycin	106-117	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	85-93
17178925-8	2007	ATP6V0C competed with Von Hippel-Lindau protein in HIF-1alpha binding by directly interacting with HIF-1alpha, which was stimulated by bafilomycin.	bafilomycin	135-146	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-109
17178925-9	2007	In confocal images, ATP6V0C was normally present in the cytoplasm but was translocated in company with HIF-1alpha to the nucleus by bafilomycin.	bafilomycin	132-143	ATPase H+ transporting V0 subunit c	Homo sapiens	20-27
17178925-9	2007	In confocal images, ATP6V0C was normally present in the cytoplasm but was translocated in company with HIF-1alpha to the nucleus by bafilomycin.	bafilomycin	132-143	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-113
17178925-11	2007	These results suggest that ATP6V0C, a novel regulator of HIF-1alpha, mediates HIF-1alpha expression by bafilomycin.	bafilomycin	103-114	ATPase H+ transporting V0 subunit c	Homo sapiens	27-34
17178925-11	2007	These results suggest that ATP6V0C, a novel regulator of HIF-1alpha, mediates HIF-1alpha expression by bafilomycin.	bafilomycin	103-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	57-67
17178925-11	2007	These results suggest that ATP6V0C, a novel regulator of HIF-1alpha, mediates HIF-1alpha expression by bafilomycin.	bafilomycin	103-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-88
17182845-6	2007	Stabilization of TfR2 by bafilomycin implies that TfR2 traffics to the lysosome for degradation.	bafilomycin	25-36	transferrin receptor 2	Homo sapiens	17-21
17182845-6	2007	Stabilization of TfR2 by bafilomycin implies that TfR2 traffics to the lysosome for degradation.	bafilomycin	25-36	transferrin receptor 2	Homo sapiens	50-54
16555000-3	2006	Pretreatment of MIN6 cells with varying concentrations of bafilomycin according to a time course revealed concentration and time-dependent changes in phosphorylation of insulin receptor signaling components.	bafilomycin	58-69	insulin receptor	Mus musculus	169-185
16920965-7	2006	Bafilomycin inhibited the induction of macrophage-induced IL-2 from T cells indicating that v-ATPase was essential for macrophage processing of Ag85B.	bafilomycin	0-11	dynein, axonemal, heavy chain 8	Mus musculus	94-100
16772302-5	2006	Bafilomycin and DIDS prevented the hyperosmolarity-induced increase in ceramide formation, p47phox phosphorylation, and ROS formation.	bafilomycin	0-11	neutrophil cytosolic factor 1	Rattus norvegicus	91-98
16670086-4	2006	The selective V-ATPase inhibitor, bafilomycin, further enhanced ATP levels, suggesting that the apical plasma membrane V-ATPase is a major consumer of ATP.	bafilomycin	34-45	Vacuolar H[+]-ATPase 55kD subunit	Drosophila melanogaster	14-22
16670086-4	2006	The selective V-ATPase inhibitor, bafilomycin, further enhanced ATP levels, suggesting that the apical plasma membrane V-ATPase is a major consumer of ATP.	bafilomycin	34-45	Vacuolar H[+]-ATPase 55kD subunit	Drosophila melanogaster	119-127
16555000-4	2006	Increased phosphorylation of insulin receptor (IR), IRS2 and Akt was prolonged at low bafilomycin concentrations (10 and 50 nmol/L), whereas at high concentrations (100 and 200 nmol/L) phosphorylation rapidly returned to basal levels or below.	bafilomycin	86-97	insulin receptor	Mus musculus	29-45
16555000-4	2006	Increased phosphorylation of insulin receptor (IR), IRS2 and Akt was prolonged at low bafilomycin concentrations (10 and 50 nmol/L), whereas at high concentrations (100 and 200 nmol/L) phosphorylation rapidly returned to basal levels or below.	bafilomycin	86-97	insulin receptor	Mus musculus	47-49
16555000-4	2006	Increased phosphorylation of insulin receptor (IR), IRS2 and Akt was prolonged at low bafilomycin concentrations (10 and 50 nmol/L), whereas at high concentrations (100 and 200 nmol/L) phosphorylation rapidly returned to basal levels or below.	bafilomycin	86-97	insulin receptor substrate 2	Mus musculus	52-56
16555000-4	2006	Increased phosphorylation of insulin receptor (IR), IRS2 and Akt was prolonged at low bafilomycin concentrations (10 and 50 nmol/L), whereas at high concentrations (100 and 200 nmol/L) phosphorylation rapidly returned to basal levels or below.	bafilomycin	86-97	thymoma viral proto-oncogene 1	Mus musculus	61-64
16555000-6	2006	Bcl2 expression was also transiently increased but reduced after 30 min exposure to bafilomycin, and this coincided with reduced cell viability.	bafilomycin	84-95	B cell leukemia/lymphoma 2	Mus musculus	0-4
16391239-1	2006	Treatment of cells with the macrolide antibiotic bafilomycin A1, an inhibitor of vacuolar (V)-ATPase, or with the lysosomotropic agent chloroquine, has been shown to pharmacologically inhibit autophagy as evidenced by an accumulation of autophagosomes, which in turn causes Bax-dependent apoptosis.	bafilomycin	49-60	ATPase H+ transporting V0 subunit a1	Homo sapiens	61-100
16391239-1	2006	Treatment of cells with the macrolide antibiotic bafilomycin A1, an inhibitor of vacuolar (V)-ATPase, or with the lysosomotropic agent chloroquine, has been shown to pharmacologically inhibit autophagy as evidenced by an accumulation of autophagosomes, which in turn causes Bax-dependent apoptosis.	bafilomycin	49-60	BCL2 associated X, apoptosis regulator	Homo sapiens	274-277
16391239-4	2006	When added separately, chloroquine or high concentrations of bafilomycin A1 (> or =10 nM) induced a dose-dependent inhibition of autophagy (as measured by an increase in LC3-II, a marker specific for autophagosomes), followed by caspase-3 activation and cell death.	bafilomycin	61-72	caspase 3	Homo sapiens	232-241