PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32035228-6	2020	We highlight recent research that the biological functions of beta-cryptoxanthin and lycopene are mediated, partially via their oxidative metabolites, through their effects on key molecular targeting events, such as NF-kappaB signaling pathway, RAR/PPARs signaling, SIRT1 signaling pathway, and p53 tumor suppressor pathways.	lycopene	85-93	sirtuin 1	Homo sapiens	266-271
32035228-6	2020	We highlight recent research that the biological functions of beta-cryptoxanthin and lycopene are mediated, partially via their oxidative metabolites, through their effects on key molecular targeting events, such as NF-kappaB signaling pathway, RAR/PPARs signaling, SIRT1 signaling pathway, and p53 tumor suppressor pathways.	lycopene	85-93	tumor protein p53	Homo sapiens	295-298
31880092-0	2020	Lycopene attenuates CP/CPPS by inhibiting oxidative stress and inflammation via the interaction of NF-kappaB, MAPKs and Nrf2 signaling pathways in rats.	lycopene	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	120-124
31790829-6	2020	In parallel, lycopene decreased LPS-/IFN-gamma-/TNFalpha-induced M1 marker mRNA levels in peritoneal macrophages, as well as TGF-beta1-induced expression of fibrogenic genes in a stellate cell line, in a dose-dependent manner.	lycopene	13-21	tumor necrosis factor	Mus musculus	48-56
31880092-9	2020	Furthermore, lycopene was suggested to reduce the levels of chemokines MCP1 and MIP-1alpha, down-regulate the expression levels of cytokines (such as TNFalpha, IL-1beta, IL-2, and IL-6), and up-regulate those of CAT, GSH-PX and T-SOD,decrease that of MDA.	lycopene	13-21	mast cell protease 1-like 1	Rattus norvegicus	71-75
31880092-9	2020	Furthermore, lycopene was suggested to reduce the levels of chemokines MCP1 and MIP-1alpha, down-regulate the expression levels of cytokines (such as TNFalpha, IL-1beta, IL-2, and IL-6), and up-regulate those of CAT, GSH-PX and T-SOD,decrease that of MDA.	lycopene	13-21	C-C motif chemokine ligand 3	Rattus norvegicus	80-90
31880092-9	2020	Furthermore, lycopene was suggested to reduce the levels of chemokines MCP1 and MIP-1alpha, down-regulate the expression levels of cytokines (such as TNFalpha, IL-1beta, IL-2, and IL-6), and up-regulate those of CAT, GSH-PX and T-SOD,decrease that of MDA.	lycopene	13-21	tumor necrosis factor	Rattus norvegicus	150-158
31880092-9	2020	Furthermore, lycopene was suggested to reduce the levels of chemokines MCP1 and MIP-1alpha, down-regulate the expression levels of cytokines (such as TNFalpha, IL-1beta, IL-2, and IL-6), and up-regulate those of CAT, GSH-PX and T-SOD,decrease that of MDA.	lycopene	13-21	interleukin 1 beta	Rattus norvegicus	160-168
31880092-9	2020	Furthermore, lycopene was suggested to reduce the levels of chemokines MCP1 and MIP-1alpha, down-regulate the expression levels of cytokines (such as TNFalpha, IL-1beta, IL-2, and IL-6), and up-regulate those of CAT, GSH-PX and T-SOD,decrease that of MDA.	lycopene	13-21	interleukin 2	Rattus norvegicus	170-174
31880092-9	2020	Furthermore, lycopene was suggested to reduce the levels of chemokines MCP1 and MIP-1alpha, down-regulate the expression levels of cytokines (such as TNFalpha, IL-1beta, IL-2, and IL-6), and up-regulate those of CAT, GSH-PX and T-SOD,decrease that of MDA.	lycopene	13-21	interleukin 6	Rattus norvegicus	180-184
31880092-11	2020	DISCUSSION AND CONCLUSIONS: Findings in this study suggest that lycopene exerts potent anti-CP effects through alleviating inflammatory response and oxidative stress (OS), which is probably attributed to the interaction of NF-kappaB, MAPKs and Nrf2 signaling pathways in rats.	lycopene	64-72	NFE2 like bZIP transcription factor 2	Rattus norvegicus	244-248
31814398-0	2020	Lycopene prevents DEHP-induced Leydig cell damage with the Nrf2 antioxidant signaling pathway in mice.	lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	59-63
31916151-8	2020	Intense TNF-alpha immunostaining was detected in the fat of BPA-treated rats but the intensity decreased when LYC was administrated with BPA.	lycopene	110-113	tumor necrosis factor	Rattus norvegicus	8-17
31916151-9	2020	In conclusion, LYC ameliorated the adverse effects of BPA on metabolism through its antioxidant potential and its reduction of TNF-alpha expression in adipose tissue.	lycopene	15-18	tumor necrosis factor	Rattus norvegicus	127-136
31982791-0	2020	Lycopene used as Anti-inflammatory Nanodrug for the Treatment of Rheumathoid Arthritis: Animal assay, Pharmacokinetics, ABC Transporter and Tissue Deposition.	lycopene	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	120-135
31954314-4	2020	The results showed that LYC administration significantly relieved AFB1-induced erythrocyte dysfunction by increasing the levels of red blood cell count (RBC), hemoglobin (HGB) and hematocrit (HCT), as well as reducing red blood cell volume distribution width (RDW) level, while the levels of mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and mean platelet volume (MPV) had no significant differences among the four groups.	lycopene	24-27	modifier of chinchilla	Mus musculus	352-355
31954314-6	2020	Furthermore, LYC also alleviated AFB1-induced erythrocyte oxidative stress by decreasing H2O2 and MDA contents and increasing SOD and CAT activities.	lycopene	13-16	catalase	Mus musculus	134-137
31814398-10	2020	In the Leydig cell, the expressions of the nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream target genes were improved through LYC-mediated protection in DEHP-induced Leydig cell damage.	lycopene	148-151	nuclear factor, erythroid derived 2, like 2	Mus musculus	43-86
31814398-10	2020	In the Leydig cell, the expressions of the nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream target genes were improved through LYC-mediated protection in DEHP-induced Leydig cell damage.	lycopene	148-151	nuclear factor, erythroid derived 2, like 2	Mus musculus	88-92
31814398-11	2020	Our findings indicated that LYC could increase the antioxidant capacity via mediating Nrf2 signaling pathway, thereby attenuating DEHP-induced Leydig cell damage.	lycopene	28-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	86-90
31996227-6	2020	RESULTS: Lycopene 10 microM resulted in higher beta-catenin and phERK1/2 protein Vs the vehicle (p = 0.04 and p = 0.006).	lycopene	9-17	catenin beta 1	Homo sapiens	47-59
31996227-10	2020	CONCLUSIONS: Lycopene activates the WNT/beta-catenin and ERK1/2 pathways, upregulates RUNX2, alkaline phosphatase, COL1A and downregulates RANKL Saos-2.	lycopene	13-21	catenin beta 1	Homo sapiens	40-52
31996227-10	2020	CONCLUSIONS: Lycopene activates the WNT/beta-catenin and ERK1/2 pathways, upregulates RUNX2, alkaline phosphatase, COL1A and downregulates RANKL Saos-2.	lycopene	13-21	mitogen-activated protein kinase 3	Homo sapiens	57-63
31996227-10	2020	CONCLUSIONS: Lycopene activates the WNT/beta-catenin and ERK1/2 pathways, upregulates RUNX2, alkaline phosphatase, COL1A and downregulates RANKL Saos-2.	lycopene	13-21	RUNX family transcription factor 2	Homo sapiens	86-91
31996227-10	2020	CONCLUSIONS: Lycopene activates the WNT/beta-catenin and ERK1/2 pathways, upregulates RUNX2, alkaline phosphatase, COL1A and downregulates RANKL Saos-2.	lycopene	13-21	TNF superfamily member 11	Homo sapiens	139-144
31860213-3	2019	The lycopene diet significantly reduced the formation of pyrimidine dimers (PDs) and the expression of proliferative cellular nuclear antigen (PCNA) in UVB-irradiated skin.	lycopene	4-12	proliferating cell nuclear antigen	Mus musculus	143-147
31816240-4	2020	The carotenoid biosynthesis-related genes: lycopene-beta-cyclase (Lcyb), beta-carotene hydroxylase (CrtZ), and capsanthin/capsolubin synthase (Ccs) were up-regulated by the red LED after 2 days of the experiment.	lycopene	43-51	lycopene beta cyclase, chloroplastic/chromoplastic	Capsicum annuum	66-70
31860213-6	2019	UVB-induced epidermal hyperplasia and PCNA expression were still remarkably inhibited by dietary lycopene, even up to 40 weeks.	lycopene	97-105	proliferating cell nuclear antigen	Mus musculus	38-42
31576860-4	2019	The primary bMEC and bovine MEC line MAC-T cells were treated with H2O2 (500 muM) and/or LYC (0.5, 1 or 2 muM) for 24 h. The results showed that treatment with LYC decreased H2O2-induced accumulation of intracellular reactive oxygen species (ROS), inflammatory cytokine (TNF-alpha, IL-6, and IL-1beta) expression and the apoptosis rate.	lycopene	160-163	tumor necrosis factor	Bos taurus	271-280
31576860-4	2019	The primary bMEC and bovine MEC line MAC-T cells were treated with H2O2 (500 muM) and/or LYC (0.5, 1 or 2 muM) for 24 h. The results showed that treatment with LYC decreased H2O2-induced accumulation of intracellular reactive oxygen species (ROS), inflammatory cytokine (TNF-alpha, IL-6, and IL-1beta) expression and the apoptosis rate.	lycopene	160-163	interferon beta-2	Bos taurus	282-286
31576860-4	2019	The primary bMEC and bovine MEC line MAC-T cells were treated with H2O2 (500 muM) and/or LYC (0.5, 1 or 2 muM) for 24 h. The results showed that treatment with LYC decreased H2O2-induced accumulation of intracellular reactive oxygen species (ROS), inflammatory cytokine (TNF-alpha, IL-6, and IL-1beta) expression and the apoptosis rate.	lycopene	160-163	interleukin 1 beta	Bos taurus	292-300
31687396-5	2019	The possible mechanisms behind such effects were examined via studying the co exposure effects of pyrene and lycopene on regulatory elements including the aryl hydrocarbon receptor (Air) and elytroid 2-related factor 2 (RF).	lycopene	109-117	aryl hydrocarbon receptor	Homo sapiens	155-180
31933889-8	2019	RESULTS: Pretreatment with lycopene significantly decreased levels of ALT, AST, and TNF-alpha and IL-6, reduced MDA content, and increased activity of SOD in serum compared with the L-C mice.	lycopene	27-35	glutamic pyruvic transaminase, soluble	Mus musculus	70-73
31933889-8	2019	RESULTS: Pretreatment with lycopene significantly decreased levels of ALT, AST, and TNF-alpha and IL-6, reduced MDA content, and increased activity of SOD in serum compared with the L-C mice.	lycopene	27-35	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	75-78
31933889-8	2019	RESULTS: Pretreatment with lycopene significantly decreased levels of ALT, AST, and TNF-alpha and IL-6, reduced MDA content, and increased activity of SOD in serum compared with the L-C mice.	lycopene	27-35	tumor necrosis factor	Mus musculus	84-93
31933889-8	2019	RESULTS: Pretreatment with lycopene significantly decreased levels of ALT, AST, and TNF-alpha and IL-6, reduced MDA content, and increased activity of SOD in serum compared with the L-C mice.	lycopene	27-35	interleukin 6	Mus musculus	98-102
31933889-9	2019	Lycopene increased expression of nuclear factor-erythroid 2 related factor 2 (Nrf2), and reduced expression of cyclooxygenase (COX)-2, and phosphorylation of nuclear factor-kappa B (NF-kappaB) and extracellular regulated protein kinases 1/2 (ERK1/2).	lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	33-76
31933889-9	2019	Lycopene increased expression of nuclear factor-erythroid 2 related factor 2 (Nrf2), and reduced expression of cyclooxygenase (COX)-2, and phosphorylation of nuclear factor-kappa B (NF-kappaB) and extracellular regulated protein kinases 1/2 (ERK1/2).	lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82
31933889-9	2019	Lycopene increased expression of nuclear factor-erythroid 2 related factor 2 (Nrf2), and reduced expression of cyclooxygenase (COX)-2, and phosphorylation of nuclear factor-kappa B (NF-kappaB) and extracellular regulated protein kinases 1/2 (ERK1/2).	lycopene	0-8	cytochrome c oxidase II, mitochondrial	Mus musculus	111-133
31933889-9	2019	Lycopene increased expression of nuclear factor-erythroid 2 related factor 2 (Nrf2), and reduced expression of cyclooxygenase (COX)-2, and phosphorylation of nuclear factor-kappa B (NF-kappaB) and extracellular regulated protein kinases 1/2 (ERK1/2).	lycopene	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	158-180
31933889-9	2019	Lycopene increased expression of nuclear factor-erythroid 2 related factor 2 (Nrf2), and reduced expression of cyclooxygenase (COX)-2, and phosphorylation of nuclear factor-kappa B (NF-kappaB) and extracellular regulated protein kinases 1/2 (ERK1/2).	lycopene	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	182-191
31933889-9	2019	Lycopene increased expression of nuclear factor-erythroid 2 related factor 2 (Nrf2), and reduced expression of cyclooxygenase (COX)-2, and phosphorylation of nuclear factor-kappa B (NF-kappaB) and extracellular regulated protein kinases 1/2 (ERK1/2).	lycopene	0-8	mitogen-activated protein kinase 3	Mus musculus	242-248
31933889-10	2019	CONCLUSION: The results showed that lycopene attenuates LPS-induced liver injury by reducing NF-kappaB/COX-2 signaling by upregulation of Nrf2/HO-1 activation.	lycopene	36-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	93-102
31933889-10	2019	CONCLUSION: The results showed that lycopene attenuates LPS-induced liver injury by reducing NF-kappaB/COX-2 signaling by upregulation of Nrf2/HO-1 activation.	lycopene	36-44	cytochrome c oxidase II, mitochondrial	Mus musculus	103-108
31933889-10	2019	CONCLUSION: The results showed that lycopene attenuates LPS-induced liver injury by reducing NF-kappaB/COX-2 signaling by upregulation of Nrf2/HO-1 activation.	lycopene	36-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	138-142
31933889-10	2019	CONCLUSION: The results showed that lycopene attenuates LPS-induced liver injury by reducing NF-kappaB/COX-2 signaling by upregulation of Nrf2/HO-1 activation.	lycopene	36-44	heme oxygenase 1	Mus musculus	143-147
31576860-0	2019	Lycopene alleviates H2O2-induced oxidative stress, inflammation and apoptosis in bovine mammary epithelial cells via the NFE2L2 signaling pathway.	lycopene	0-8	NFE2 like bZIP transcription factor 2	Bos taurus	121-127
31933889-0	2019	Lycopene attenuates LPS-induced liver injury by inactivation of NF-kappaB/COX-2 signaling.	lycopene	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	64-73
31933889-0	2019	Lycopene attenuates LPS-induced liver injury by inactivation of NF-kappaB/COX-2 signaling.	lycopene	0-8	cytochrome c oxidase II, mitochondrial	Mus musculus	74-79