PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33216827-0	2020	Anti-tumor activities of the new oral pan-RAF inhibitor, TAK-580, used as monotherapy or in combination with novel agents in multiple myeloma.	tak-580	57-64	zinc fingers and homeoboxes 2	Homo sapiens	42-45
33216827-2	2020	The pan-RAF inhibitor, TAK-580, is a representative of the novel RAF inhibitors that act by disrupting RAF homo- or heterodimerization.	tak-580	23-30	zinc fingers and homeoboxes 2	Homo sapiens	8-11
33216827-2	2020	The pan-RAF inhibitor, TAK-580, is a representative of the novel RAF inhibitors that act by disrupting RAF homo- or heterodimerization.	tak-580	23-30	zinc fingers and homeoboxes 2	Homo sapiens	65-68
33216827-7	2020	Moreover, TAK-580 enhanced bortezomib-induced cytotoxicity and apoptosis in MM cells via the FOXO3-Bim axis and the terminal unfolded protein response.	tak-580	10-17	forkhead box O3	Homo sapiens	93-98
33216827-2	2020	The pan-RAF inhibitor, TAK-580, is a representative of the novel RAF inhibitors that act by disrupting RAF homo- or heterodimerization.	tak-580	23-30	zinc fingers and homeoboxes 2	Homo sapiens	65-68
33216827-4	2020	TAK-580 monotherapy potently targeted proteins in the RAS-RAF-MEK-ERK signaling pathway and induced potent cytotoxicity and apoptosis in MM cell lines and myeloma cells from patients with newly diagnosed and relapsed and/or refractory MM, compared with a representative RAF inhibitor, dabrafenib.	tak-580	0-7	zinc fingers and homeoboxes 2	Homo sapiens	58-61
33216827-7	2020	Moreover, TAK-580 enhanced bortezomib-induced cytotoxicity and apoptosis in MM cells via the FOXO3-Bim axis and the terminal unfolded protein response.	tak-580	10-17	BCL2 like 11	Homo sapiens	99-102
33216827-4	2020	TAK-580 monotherapy potently targeted proteins in the RAS-RAF-MEK-ERK signaling pathway and induced potent cytotoxicity and apoptosis in MM cell lines and myeloma cells from patients with newly diagnosed and relapsed and/or refractory MM, compared with a representative RAF inhibitor, dabrafenib.	tak-580	0-7	mitogen-activated protein kinase kinase 7	Homo sapiens	62-65
33216827-4	2020	TAK-580 monotherapy potently targeted proteins in the RAS-RAF-MEK-ERK signaling pathway and induced potent cytotoxicity and apoptosis in MM cell lines and myeloma cells from patients with newly diagnosed and relapsed and/or refractory MM, compared with a representative RAF inhibitor, dabrafenib.	tak-580	0-7	mitogen-activated protein kinase 1	Homo sapiens	66-69
33216827-4	2020	TAK-580 monotherapy potently targeted proteins in the RAS-RAF-MEK-ERK signaling pathway and induced potent cytotoxicity and apoptosis in MM cell lines and myeloma cells from patients with newly diagnosed and relapsed and/or refractory MM, compared with a representative RAF inhibitor, dabrafenib.	tak-580	0-7	zinc fingers and homeoboxes 2	Homo sapiens	270-273
33216827-6	2020	Importantly, TAK-580 significantly inhibited phospho-FOXO3 and induced upregulation of BimL and BimS in a dose-dependent manner, finally leading to apoptosis in MM cells.	tak-580	13-20	forkhead box O3	Homo sapiens	53-58
30622172-6	2019	In vitro studies using transfected Madin-Darby canine kidney II cells indicate that only LY3009120 and MLN2480 are substrates of Bcrp, and none of the three inhibitors are substrates of P-gp.	tak-580	103-110	ATP binding cassette subfamily G member 2	Canis lupus familiaris	129-133
30622172-8	2019	In vivo studies in mice show that the brain distribution of CCT196969, LY3009120, and MLN2480 is limited, and is enhanced in transgenic mice lacking P-gp and Bcrp.	tak-580	86-93	phosphoglycolate phosphatase	Mus musculus	149-153
30622172-8	2019	In vivo studies in mice show that the brain distribution of CCT196969, LY3009120, and MLN2480 is limited, and is enhanced in transgenic mice lacking P-gp and Bcrp.	tak-580	86-93	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	158-162
34741230-0	2022	Anti-tumor activity of the pan-RAF inhibitor TAK-580 in combination with KPT-330 (selinexor) in multiple myeloma.	tak-580	45-52	zinc fingers and homeoboxes 2	Homo sapiens	31-34
34741230-3	2022	In this study, we explored the anti-tumor effects of a combination of the pan-RAF inhibitor TAK-580 and KPT-330.	tak-580	92-99	zinc fingers and homeoboxes 2	Homo sapiens	78-81
34741230-6	2022	This indicates that TAK-580 enhances KPT-330-induced cytotoxicity and apoptosis primarily via the FOXO3a-Bim axis.	tak-580	20-27	forkhead box O3	Homo sapiens	98-104
34741230-6	2022	This indicates that TAK-580 enhances KPT-330-induced cytotoxicity and apoptosis primarily via the FOXO3a-Bim axis.	tak-580	20-27	BCL2 like 11	Homo sapiens	105-108