PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28124818-6	2017	This group of rare designed hexasaccharides will help understand HCII function.	hexasaccharides	28-43	serpin family D member 1	Homo sapiens	65-69
24178304-5	2013	In previous studies, we have found that two synthetic hexasaccharides having the sulphate groups directed towards one side of its central plane have an opposite biological activity, while 1 is unable to activate the FGF-1 signalling pathway, the other (2) is even more active than the regular region derived hexasaccharide (3) that mimics the natural active compound, heparin.	hexasaccharides	54-69	fibroblast growth factor 1	Homo sapiens	216-221
27801570-7	2016	The structural difference between the two hexasaccharides was defined as the differential location of a single sulfate at either C-6 of glucosamine or C-2 of uronic acid in the reducing disaccharide, resulting in a 200-fold difference in binding affinity for MCP-1.	hexasaccharides	42-57	C-C motif chemokine ligand 2	Homo sapiens	259-264
25015527-2	2014	In this study, we report the binding affinities between five synthetic hexasaccharides with human FGF-1 obtained by surface plasmon resonance experiments, and compare with the induced mitogenic activity previously obtained.	hexasaccharides	71-86	fibroblast growth factor 1	Homo sapiens	98-103
25124036-6	2014	We show here that the gastric glycoform of TFF2 is a calcium-independent lectin, which binds with high specificity to O-linked alpha1,4-GlcNAc-capped hexasaccharides on human and porcine stomach mucin.	hexasaccharides	150-165	trefoil factor 2	Homo sapiens	43-47
25124036-6	2014	We show here that the gastric glycoform of TFF2 is a calcium-independent lectin, which binds with high specificity to O-linked alpha1,4-GlcNAc-capped hexasaccharides on human and porcine stomach mucin.	hexasaccharides	150-165	LOC100508689	Homo sapiens	195-200
18757435-9	2008	Chemically synthesized CSE hexasaccharides also enhanced the CD44 cleavage and tumor cell motility in a CD44-dependent manner.	hexasaccharides	27-42	CD44 molecule (Indian blood group)	Homo sapiens	104-108
20623566-12	2010	As a proof of principle, this panel of hexasaccharides was used to probe the effect of backbone sequence on binding with the fibroblast growth factor-2 (FGF-2).	hexasaccharides	39-54	fibroblast growth factor 2	Homo sapiens	125-151
20623566-12	2010	As a proof of principle, this panel of hexasaccharides was used to probe the effect of backbone sequence on binding with the fibroblast growth factor-2 (FGF-2).	hexasaccharides	39-54	fibroblast growth factor 2	Homo sapiens	153-158
18757435-9	2008	Chemically synthesized CSE hexasaccharides also enhanced the CD44 cleavage and tumor cell motility in a CD44-dependent manner.	hexasaccharides	27-42	CD44 molecule (Indian blood group)	Homo sapiens	61-65
15324304-6	2004	On the other hand, when [35S]glycosaminoglycans formed from DSDS after incubation with [35S]PAPS and C6ST-1 were digested with chondroitinase ACII, a major part of the radioactivity was recovered in fractions larger than hexasaccharides, indicating that C6ST-1 transferred sulphate to the GalNAc residues located in the L-iduronic acid-rich region.	hexasaccharides	221-236	carbohydrate sulfotransferase 3	Rattus norvegicus	101-107
16648633-7	2006	MMP-13 expression was also induced in articular chondrocytes by hyaluronan (HA) hexasaccharides but not by HA tetrasaccharides nor high molecular weight hyaluronan.	hexasaccharides	80-95	matrix metallopeptidase 13	Homo sapiens	0-6
18260648-8	2008	The specificity of the hexasaccharides binding ATIII was confirmed by assaying their ability to enhance ATIII-mediated inhibition of Factor Xa in vitro.	hexasaccharides	23-38	serpin family C member 1	Homo sapiens	47-52
18260648-8	2008	The specificity of the hexasaccharides binding ATIII was confirmed by assaying their ability to enhance ATIII-mediated inhibition of Factor Xa in vitro.	hexasaccharides	23-38	serpin family C member 1	Homo sapiens	104-109
18260648-8	2008	The specificity of the hexasaccharides binding ATIII was confirmed by assaying their ability to enhance ATIII-mediated inhibition of Factor Xa in vitro.	hexasaccharides	23-38	coagulation factor X	Homo sapiens	133-142
16624894-7	2006	We found that the smallest oligosaccharides able to bind HCII were hexasaccharides.	hexasaccharides	67-82	serpin family D member 1	Homo sapiens	57-61
16303928-8	2005	Binding inhibition studies showed that hexasaccharides of heparin had a lower affinity for opticin than larger oligosaccharides; the sulfate groups of heparin contributed variably to opticin binding, with the group at ring position two of iduronate contributing least; and chondroitin sulfate A and B bound to opticin, whereas binding to chondroitin sulfate C and hyaluronan was not observed.	hexasaccharides	39-54	opticin	Homo sapiens	91-98
15526371-11	2004	The most effective inhibitors of IL-4 and IL-5 secretion are tetrasaccharides and hexasaccharides, respectively.	hexasaccharides	82-97	interleukin 4	Homo sapiens	33-37
15526371-11	2004	The most effective inhibitors of IL-4 and IL-5 secretion are tetrasaccharides and hexasaccharides, respectively.	hexasaccharides	82-97	interleukin 5	Homo sapiens	42-46
10497173-6	1999	Hexasaccharides represent the minimum sized heparin fragments able to interact with GST-Tat at physiological ionic strength.	hexasaccharides	0-15	tyrosine aminotransferase	Homo sapiens	88-91
10466207-1	1999	Three hexasaccharides, having from low to very high affinity for antithrombin, were synthesised from disaccharide building block precursors.	hexasaccharides	6-21	serpin family C member 1	Homo sapiens	65-77
9492275-0	1998	Structural characterisation of two hexasaccharides and an octasaccharide from chondroitin sulphate C containing the unusual sequence (4-sulpho)-N-acetylgalactosamine-beta1-4-(2-sulpho)-glucuronic acid-beta1-3-(6-sulpho)-N-acetylgalactosamine.	hexasaccharides	35-50	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	166-173
8444842-1	1993	We demonstrated previously that heparin-derived hexasaccharides are the smallest fragments of the polysaccharide with comparable basic fibroblast growth factor (bFGF)-modulating activity in vitro (Ishihara, M., Tyrrell, D.J., Stauber, G.B., Brown, S., Cousens, L., and Stack, R.J. (1993) J. Biol.	hexasaccharides	48-63	fibroblast growth factor 2	Homo sapiens	129-159
1323463-0	1992	Characterisation by mass spectrometry and 1H-NMR of novel hexasaccharides among the acidic O-linked carbohydrate chains of bovine submaxillary mucin.	hexasaccharides	58-73	mucin 1, cell surface associated	Bos taurus	143-148
2211700-7	1990	The smallest HCII-binding fragments were hexasaccharides, of which approximately 6% bound.	hexasaccharides	41-56	serpin family D member 1	Homo sapiens	13-17
2211700-9	1990	Subsequently, hexasaccharides with the highest affinity for HCII were isolated by overloading the HCII-Sepharose column.	hexasaccharides	14-29	serpin family D member 1	Homo sapiens	60-64
2211700-9	1990	Subsequently, hexasaccharides with the highest affinity for HCII were isolated by overloading the HCII-Sepharose column.	hexasaccharides	14-29	serpin family D member 1	Homo sapiens	98-102
35433769-11	2022	Additionally, ATIII-binding pentasaccharides with an extra 3-O-sulfate at the reducing glucosamine are detected in fractions of highest affinity as heparinase II-resistant hexasaccharides with two consecutive 3-O-sulfated units.	hexasaccharides	172-187	serpin family C member 1	Bos taurus	14-19
9174673-13	1997	Hexasaccharides were found to be the smallest fragments able to potentiate the FGF-1-induced 3T3 cell proliferation while their effect on FGF-2 signaling was less clear.	hexasaccharides	0-15	fibroblast growth factor 1	Mus musculus	79-84
1826222-6	1991	The increased amount of the hexasaccharides in acute leukemia is associated with increased activity of beta 1----6 GlcNAc-transferase, a key enzyme in forming the hexasaccharides.	hexasaccharides	28-43	glucosaminyl (N-acetyl) transferase 3, mucin type	Homo sapiens	103-133
1826222-6	1991	The increased amount of the hexasaccharides in acute leukemia is associated with increased activity of beta 1----6 GlcNAc-transferase, a key enzyme in forming the hexasaccharides.	hexasaccharides	163-178	glucosaminyl (N-acetyl) transferase 3, mucin type	Homo sapiens	103-133
1826222-7	1991	Immunoblot analysis of cell lysates showed that monoclonal antibody (MoAb) T-305 reacts preferentially with leukosialin of high mol wt containing the hexasaccharides.	hexasaccharides	150-165	LOC105369247	Homo sapiens	108-119
2708348-12	1989	The potentiation of aFGF by the high sulfate fraction correlated with the saccharide size: 12 or more monosaccharide units were necessary to achieve potentiation equivalent to whole heparin, octa- and decasaccharides were mildly stimulatory, and hexasaccharides were without effect.	hexasaccharides	246-261	fibroblast growth factor 1	Bos taurus	20-24
2415652-7	1985	In contrast, over 50% of the O-linked oligosaccharides in hCG beta from the JAr choriocarcinoma cell line are hexasaccharides.	hexasaccharides	110-125	chorionic gonadotropin subunit beta 3	Homo sapiens	58-66
6940150-2	1981	Direct measurements of the kinetic behavior of the hexasaccharides, octasaccharides, and decasaccharides showed that these fractions greatly enhanced the rate of Factor Xa inactivation by antithrombin.	hexasaccharides	51-66	coagulation factor X	Homo sapiens	162-171
6940150-2	1981	Direct measurements of the kinetic behavior of the hexasaccharides, octasaccharides, and decasaccharides showed that these fractions greatly enhanced the rate of Factor Xa inactivation by antithrombin.	hexasaccharides	51-66	serpin family C member 1	Homo sapiens	188-200
6940150-5	1981	The avidity of the hexasaccharides, octasaccharides, and decasaccharides for the protease inhibitor increased as a function of size with the respective dissociation constants ranging from 5.5 X 10(-6) M to 2.9 X 10(-7) M. These data suggest that the region of the heparin molecule needed for catalyzing Factor Xa-antithrombin interaction is intimately related to the antithrombin binding domain.	hexasaccharides	19-34	coagulation factor X	Homo sapiens	303-312
6940150-5	1981	The avidity of the hexasaccharides, octasaccharides, and decasaccharides for the protease inhibitor increased as a function of size with the respective dissociation constants ranging from 5.5 X 10(-6) M to 2.9 X 10(-7) M. These data suggest that the region of the heparin molecule needed for catalyzing Factor Xa-antithrombin interaction is intimately related to the antithrombin binding domain.	hexasaccharides	19-34	serpin family C member 1	Homo sapiens	313-325
6940150-5	1981	The avidity of the hexasaccharides, octasaccharides, and decasaccharides for the protease inhibitor increased as a function of size with the respective dissociation constants ranging from 5.5 X 10(-6) M to 2.9 X 10(-7) M. These data suggest that the region of the heparin molecule needed for catalyzing Factor Xa-antithrombin interaction is intimately related to the antithrombin binding domain.	hexasaccharides	19-34	serpin family C member 1	Homo sapiens	367-379
4185041-2	1969	Binding of labeled hexasaccharides derived from S3 by anti-S3 antibodies and their Fab fragments.	hexasaccharides	19-34	FA complementation group B	Homo sapiens	83-86