PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18384088-7	2008	The growth arrest and DNA damage (GADD)-inducible transcription factor 153 (GADD153) mRNA and protein is markedly induced in a time- and concentration-dependent manner in response to 6-shogaol.	gadd	34-38	DNA damage inducible transcript 3	Homo sapiens	76-83
16912197-5	2006	Employing rationally designed mutational analysis, we show that MDA-7/IL-24 and M4 physically interact with BiP/GRP78 through their C and F helices, localize in the endoplasmic reticulum, and activate p38 MAPK and GADD gene expression, culminating in cancer-selective apoptosis.	gadd	214-218	interleukin 24	Homo sapiens	64-69
16912197-5	2006	Employing rationally designed mutational analysis, we show that MDA-7/IL-24 and M4 physically interact with BiP/GRP78 through their C and F helices, localize in the endoplasmic reticulum, and activate p38 MAPK and GADD gene expression, culminating in cancer-selective apoptosis.	gadd	214-218	interleukin 24	Homo sapiens	70-75
16912197-5	2006	Employing rationally designed mutational analysis, we show that MDA-7/IL-24 and M4 physically interact with BiP/GRP78 through their C and F helices, localize in the endoplasmic reticulum, and activate p38 MAPK and GADD gene expression, culminating in cancer-selective apoptosis.	gadd	214-218	heat shock protein family A (Hsp70) member 5	Homo sapiens	108-111
16912197-5	2006	Employing rationally designed mutational analysis, we show that MDA-7/IL-24 and M4 physically interact with BiP/GRP78 through their C and F helices, localize in the endoplasmic reticulum, and activate p38 MAPK and GADD gene expression, culminating in cancer-selective apoptosis.	gadd	214-218	heat shock protein family A (Hsp70) member 5	Homo sapiens	112-117
16283526-3	2005	In addition to gadd45alpha, the basal expression of other gadd family members including gadd45beta, gadd45gamma and gadd153 was substantially increased in Ikkbeta-/- cells.	gadd	15-19	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	155-162
16206274-10	2006	In particular, the compound upregulated 2 members of the growth arrest and DNA damage (Gadd) inducible gene family, Gadd34 and Gadd153.	gadd	87-91	protein phosphatase 1, regulatory subunit 15A	Rattus norvegicus	116-122
16206274-10	2006	In particular, the compound upregulated 2 members of the growth arrest and DNA damage (Gadd) inducible gene family, Gadd34 and Gadd153.	gadd	87-91	DNA-damage inducible transcript 3	Rattus norvegicus	127-134
16283526-6	2005	Thus, these results uncover the molecular mechanism by which NF-kappaB signalling contributes to the regulation of gadd family gene expression induced by arsenic.	gadd	115-119	nuclear factor kappa B subunit 1	Homo sapiens	61-70
15984772-9	2005	The expression of the metallothionein mt2 and the DNA repair rad51 genes was up-regulated in liver between 21 and 63 days, whereas in skeletal muscle, mt2 remained uninduced, and gadd and rad51 were found to be repressed.	gadd	179-183	RAD51 recombinase	Danio rerio	61-66
15184144-7	2004	The sigma(B) dependence of the gad genes (gadA, gadB, gadC, gadD, and gadE) was analyzed in silico.	gadd	60-64	lmo2363	Listeria monocytogenes EGD-e	31-34
12606943-6	2003	We presently demonstrate that Ad.mda-7 induces growth inhibition and apoptosis in malignant human gliomas expressing both mutant and wild-type p53, and these effects correlate with an elevation in expression of members of the growth arrest and DNA damage (GADD) gene family.	gadd	256-260	interleukin 24	Homo sapiens	33-38
15021909-5	2004	c-Myc represses both the basal expression and the magnitude of ER stress induction of GADD gene transcription.	gadd	86-90	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
15021909-8	2004	c-Myc-associated protein X (Max) is also bound to both GADD gene promoters, whereas c-Myc interacting zinc-finger protein 1 (Miz-1) is bound to the GADD153, but not GADD45a, promoter.	gadd	55-59	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
15021909-9	2004	RNA polymerase II (RNAPII) is recruited to the GADD gene promoters in the presence and absence of c-Myc, which suggests that c-Myc represses these genes through a post-RNAPII recruitment mechanism.	gadd	47-51	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	125-130
14645667-2	2003	The stress-inducible transcription factor known as growth and DNA damage (GADD)-inducible transcription factor 153 is induced in response to fenretinide and in other cell types modulates apoptosis via pro- and antiapoptotic members of the BCL2 family.	gadd	74-78	BCL2 apoptosis regulator	Homo sapiens	239-243
14656072-6	2003	The endoplasmic reticulum response, mediated by activation of ATF-6 and NF-kappaB, leads to activation of gadd 153.	gadd	106-110	cyclic AMP-dependent transcription factor ATF-6 alpha	Oryctolagus cuniculus	62-67
12606943-9	2003	Moreover, infection of gliomas with Ad.mda-7 or treatment with purified GST-MDA-7 protein sensitizes both wild-type and mutant p53 expressing tumor cells to the growth inhibitory and antisurvival effects of ionizing radiation, and this response correlates with increased expression of specific members of the GADD gene family.	gadd	309-313	interleukin 24	Homo sapiens	39-44
12606943-9	2003	Moreover, infection of gliomas with Ad.mda-7 or treatment with purified GST-MDA-7 protein sensitizes both wild-type and mutant p53 expressing tumor cells to the growth inhibitory and antisurvival effects of ionizing radiation, and this response correlates with increased expression of specific members of the GADD gene family.	gadd	309-313	interleukin 24	Homo sapiens	76-81
10710528-2	2000	The present study was designed to determine whether hyperoxia also increased expression of the growth arrest and DNA damage (GADD) gene 45 and GADD153, which are induced by genotoxic stress through p53-dependent and -independent pathways.	gadd	125-129	transformation related protein 53, pseudogene	Mus musculus	198-201
12114539-10	2002	In addition, SB203580 effectively inhibited Ad.mda-7-mediated induction of the GADD family of genes in a time- and dose-dependent manner, and it effectively blocked Ad.mda-7-mediated down-regulation of the antiapoptotic protein BCL-2.	gadd	79-83	interleukin 24	Homo sapiens	47-52
12114539-10	2002	In addition, SB203580 effectively inhibited Ad.mda-7-mediated induction of the GADD family of genes in a time- and dose-dependent manner, and it effectively blocked Ad.mda-7-mediated down-regulation of the antiapoptotic protein BCL-2.	gadd	79-83	interleukin 24	Homo sapiens	168-173
12114539-11	2002	Inhibition of GADD genes by an antisense approach either alone or in combination also effectively blocked Ad.mda-7-induced apoptosis in melanoma cells.	gadd	14-18	interleukin 24	Homo sapiens	109-114
12114539-12	2002	These results support the hypothesis that Ad.mda-7 mediates induction of the GADD family of genes by means of the p38 MAPK pathway, thereby resulting in the selective induction of apoptosis in human melanoma cells.	gadd	77-81	interleukin 24	Homo sapiens	45-50
11163539-2	2001	A peroxynitrite generator, 3-morpholinosydonimine (SIN-1), was found to induce the expression of three different growth arrest and DNA damage-inducible (GADD) mRNA, GADD34, GADD45, and GADD153, at the early phase during cell death in human neuroblastoma SH-SY5Y cells.	gadd	153-157	MAPK associated protein 1	Homo sapiens	51-56
11163539-4	2001	A specific inhibitor of p38 MAPK, SB202190, markedly suppressed peroxynitrite-induced expression of three GADD mRNA in SH-SY5Y cells.	gadd	106-110	mitogen-activated protein kinase 14	Homo sapiens	24-27
11163539-5	2001	The expression of three GADD genes and also p38 MAPK phosphorylation were suppressed by treatment with radical scavengers, superoxide dismutase plus catalase and glutathione.	gadd	24-28	catalase	Homo sapiens	149-157
11163539-7	2001	These findings indicate that peroxynitrite-mediated oxidative stress activated p38 MAPK to induce three GADD genes.	gadd	104-108	mitogen-activated protein kinase 14	Homo sapiens	79-82
12482972-3	2003	Here we report that MLL is normally cleaved at two conserved sites (D/GADD and D/GVDD) and that mutation of these sites abolishes the proteolysis.	gadd	70-74	lysine methyltransferase 2A	Homo sapiens	20-23
12114539-0	2002	mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.	gadd	117-121	interleukin 24	Homo sapiens	0-5
12114539-0	2002	mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.	gadd	117-121	interleukin 24	Homo sapiens	7-12
12114539-5	2002	Infection of melanoma cells, but not normal immortal melanocytes, with Ad.mda-7 induced a time- and dose-dependent increase in expression, mRNA and protein, of a family of growth arrest and DNA damage (GADD)-inducible genes, which correlated with induction of apoptosis.	gadd	202-206	interleukin 24	Homo sapiens	74-79
12114539-6	2002	Among the members of the GADD family of genes, GADD153, GADD45 alpha, and GADD34 displayed marked, and GADD45 gamma showed minimal induction.	gadd	25-29	DNA damage inducible transcript 3	Homo sapiens	47-54
12114539-6	2002	Among the members of the GADD family of genes, GADD153, GADD45 alpha, and GADD34 displayed marked, and GADD45 gamma showed minimal induction.	gadd	25-29	growth arrest and DNA damage inducible alpha	Homo sapiens	56-68
12114539-6	2002	Among the members of the GADD family of genes, GADD153, GADD45 alpha, and GADD34 displayed marked, and GADD45 gamma showed minimal induction.	gadd	25-29	protein phosphatase 1 regulatory subunit 15A	Homo sapiens	74-80
12114539-6	2002	Among the members of the GADD family of genes, GADD153, GADD45 alpha, and GADD34 displayed marked, and GADD45 gamma showed minimal induction.	gadd	25-29	growth arrest and DNA damage inducible gamma	Homo sapiens	103-115
11593333-5	2001	This heat stress also resulted in a 3-fold increase in TNF-alpha gene expression driven by the gadd 153 promoter as compared with that of nonheated tumor.	gadd	95-99	tumor necrosis factor	Mus musculus	55-64
10710528-6	2000	Hyperoxia also increased GADD expression in p53-deficient mice.	gadd	25-29	transformation related protein 53, pseudogene	Mus musculus	44-47
10497233-8	1999	Nuclear run-on assays and mRNA decay studies suggested that the primary mechanism leading to increased GADD mRNA levels was not transcriptional, but rather that GADD45 and GADD153/CHOP expression were up-regulated in response to GLN deprivation via marked stabilization of these mRNAs.	gadd	103-107	DNA damage inducible transcript 3	Homo sapiens	180-184
10656618-12	1999	The data presented herein suggest that PKC is a potential upstream target for MSC that may trigger one or all of the downstream effects; i.e. the decrease of cdk2 kinase activity, decreased DNA synthesis, elevation of gadd gene expression and finally apoptosis.	gadd	218-222	protein kinase C, alpha	Mus musculus	39-42
8623544-8	1996	Considering the role of IL-6 in inflammation, immune response, and its known association with increased levels of MyD116 and GADD 34 mRNAs (genes involved in the prevention of apoptotic death of cells), the present data may have relevance to HSV-1-mediated diseases as well as to the prevalence of HSV-1 in the host.	gadd	125-129	interleukin 6	Homo sapiens	24-28
9927805-8	1998	The p53 gene encodes a transcription factor that contributes to several different cellular activities, including apoptosis, the cellular response to radiation, and the activation of proteins such as GADD, Bcl-2 (represses to apoptosis) and Bax.	gadd	199-203	tumor protein p53	Homo sapiens	4-7
9429083-10	1997	Response elements for human CYP1A1, GST lambda a, xenobiotic response element (XRE), fos, HSP70, CRE, p53, NF kappa B and DNA damage (GADD) in HepG2 cells were not activated by quercetin.	gadd	134-138	glutathione S-transferase kappa 1	Homo sapiens	36-39
8892753-3	1996	In contrast, the gadd gene stress response to base-damaging agents, such as methylmethane sulfonate (MMS) or UV radiation, or medium depletion (starvation) occurs in all mammalian cells examined to date regardless of p53 status for both GADD45 and also GADD153, which is not IR-responsive in many lines with functional p53.	gadd	17-21	growth arrest and DNA damage inducible alpha	Homo sapiens	237-243
8892753-3	1996	In contrast, the gadd gene stress response to base-damaging agents, such as methylmethane sulfonate (MMS) or UV radiation, or medium depletion (starvation) occurs in all mammalian cells examined to date regardless of p53 status for both GADD45 and also GADD153, which is not IR-responsive in many lines with functional p53.	gadd	17-21	DNA damage inducible transcript 3	Homo sapiens	253-260
8892753-3	1996	In contrast, the gadd gene stress response to base-damaging agents, such as methylmethane sulfonate (MMS) or UV radiation, or medium depletion (starvation) occurs in all mammalian cells examined to date regardless of p53 status for both GADD45 and also GADD153, which is not IR-responsive in many lines with functional p53.	gadd	17-21	tumor protein p53	Homo sapiens	319-322
9926927-0	1999	PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes.	gadd	67-71	sestrin 1	Homo sapiens	0-4
9926927-7	1999	Our results suggest that the PA26 gene is a novel p53 target gene with properties common to the GADD family of growth arrest and DNA damage-inducible stress-response genes, and, thus, a potential novel regulator of cellular growth.	gadd	96-100	sestrin 1	Homo sapiens	29-33
9926927-7	1999	Our results suggest that the PA26 gene is a novel p53 target gene with properties common to the GADD family of growth arrest and DNA damage-inducible stress-response genes, and, thus, a potential novel regulator of cellular growth.	gadd	96-100	tumor protein p53	Homo sapiens	50-53
9593703-7	1998	We demonstrated that at 24 and 48 h after onset of hyperosmolality, but not in isosmotic controls, growth arrest and DNA damage-inducible (GADD) proteins GADD45 and GADD153 are strongly induced.	gadd	139-143	growth arrest and DNA-damage-inducible 45 alpha	Mus musculus	154-160
9593703-7	1998	We demonstrated that at 24 and 48 h after onset of hyperosmolality, but not in isosmotic controls, growth arrest and DNA damage-inducible (GADD) proteins GADD45 and GADD153 are strongly induced.	gadd	139-143	DNA-damage inducible transcript 3	Mus musculus	165-172
9413226-8	1997	Our conclusion is that GADD proteins play an important role in the malignant transformation of naevus to melanoma and GADD 45 and GADD 153 proteins can influence patient survival.	gadd	23-27	DNA damage inducible transcript 3	Homo sapiens	130-138
9256446-9	1997	These results indicate that PEG-3 is a new member of the gadd and MyD gene family with similar yet distinct properties and this gene may directly contribute to the transformation progression phenotype.	gadd	57-61	paternally expressed 3	Rattus norvegicus	28-33
2272308-8	1990	These data suggest that the missing region on chromosome 7 in the c14CoS/c14CoS mouse contains a gene(s), which we propose to call Nmo-1n, encoding a trans-acting factor(s) that is a negative effector of the Nmo-1 and gadd genes.	gadd	218-222	NAD(P)H dehydrogenase, quinone 1	Mus musculus	131-136
9019159-8	1995	gas6 is an exception to the general concordance of mitotic growth arrest and gas/gadd expression in that gas6 is preferentially expressed during the clonal expansion of postconfluent adipoblasts.	gadd	81-85	growth arrest specific 6	Mus musculus	0-4
9019159-8	1995	gas6 is an exception to the general concordance of mitotic growth arrest and gas/gadd expression in that gas6 is preferentially expressed during the clonal expansion of postconfluent adipoblasts.	gadd	81-85	growth arrest specific 6	Mus musculus	105-109
8168107-2	1994	Unlike GADD45, the response of other DNA damage-inducible genes to IR is not dependent on p53 based on the observation that induction in a panel of cell lines did not correlate with a normal p53 status; this included human GADD153, another member of the gadd (growth arrest and DNA damage inducible) group; MyD118, a gene related to GADD45; and the protooncogenes c-jun and c-fos.	gadd	254-258	DNA damage inducible transcript 3	Homo sapiens	223-230
7923549-8	1994	Recent work has shown that DNA damaging agents activate signaling cascades one of which involves the Src, Ras, and Raf proteins as intermediates and results in induction of a number of genes, including c-fos, c-jun, and the growth arrest and DNA damage-inducible (gadd) genes.	gadd	264-268	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	101-104
7923549-8	1994	Recent work has shown that DNA damaging agents activate signaling cascades one of which involves the Src, Ras, and Raf proteins as intermediates and results in induction of a number of genes, including c-fos, c-jun, and the growth arrest and DNA damage-inducible (gadd) genes.	gadd	264-268	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	202-207
7923549-8	1994	Recent work has shown that DNA damaging agents activate signaling cascades one of which involves the Src, Ras, and Raf proteins as intermediates and results in induction of a number of genes, including c-fos, c-jun, and the growth arrest and DNA damage-inducible (gadd) genes.	gadd	264-268	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	209-214
29227599-0	2016	Inhibition of IRE1 modifies the hypoxic regulation of GADD family gene expressions in U87 glioma cells.	gadd	54-58	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	14-18
26867644-8	2016	In line with ROS generation, oxidative damages and the arrest of normal cell proliferation, GADD genes (Growth Arrest and DNA Damage) that include GADD45 and GADD153, were significantly up-regulated.	gadd	92-96	growth arrest and DNA-damage-inducible 45 alpha	Mus musculus	147-153
26867644-8	2016	In line with ROS generation, oxidative damages and the arrest of normal cell proliferation, GADD genes (Growth Arrest and DNA Damage) that include GADD45 and GADD153, were significantly up-regulated.	gadd	92-96	DNA-damage inducible transcript 3	Mus musculus	158-165
28444170-5	2017	Neuronal activity together with BDNF and TGFB controls transcription of DNA modifying enzymes specifically members of the DNA-damage-inducible (Gadd) family, Gadd45a, Gadd45b, and Gadd45g.	gadd	144-148	brain derived neurotrophic factor	Mus musculus	32-36
28444170-5	2017	Neuronal activity together with BDNF and TGFB controls transcription of DNA modifying enzymes specifically members of the DNA-damage-inducible (Gadd) family, Gadd45a, Gadd45b, and Gadd45g.	gadd	144-148	transforming growth factor, beta 1	Mus musculus	41-45
28444170-5	2017	Neuronal activity together with BDNF and TGFB controls transcription of DNA modifying enzymes specifically members of the DNA-damage-inducible (Gadd) family, Gadd45a, Gadd45b, and Gadd45g.	gadd	144-148	growth arrest and DNA-damage-inducible 45 alpha	Mus musculus	158-165
29227599-1	2016	We have studied hypoxic regulation of the expression of genes encoded GADD (growth arrest and DNAdamage) family proteins in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme-1),which controls cell proliferation and tumor growth as a central mediator of endoplasmic reticulum stress.We have shown that hypoxia up-regulates the expression of GADD34, GADD45A, GADD45B, and GADD153genes, which are related to cell proliferation and apoptosis, in control (transfected by empty vector) gliomacells in gene specific manner.	gadd	70-74	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	170-174
29227599-1	2016	We have studied hypoxic regulation of the expression of genes encoded GADD (growth arrest and DNAdamage) family proteins in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme-1),which controls cell proliferation and tumor growth as a central mediator of endoplasmic reticulum stress.We have shown that hypoxia up-regulates the expression of GADD34, GADD45A, GADD45B, and GADD153genes, which are related to cell proliferation and apoptosis, in control (transfected by empty vector) gliomacells in gene specific manner.	gadd	70-74	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	176-203
29227599-1	2016	We have studied hypoxic regulation of the expression of genes encoded GADD (growth arrest and DNAdamage) family proteins in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme-1),which controls cell proliferation and tumor growth as a central mediator of endoplasmic reticulum stress.We have shown that hypoxia up-regulates the expression of GADD34, GADD45A, GADD45B, and GADD153genes, which are related to cell proliferation and apoptosis, in control (transfected by empty vector) gliomacells in gene specific manner.	gadd	70-74	protein phosphatase 1 regulatory subunit 15A	Homo sapiens	368-374
29227599-1	2016	We have studied hypoxic regulation of the expression of genes encoded GADD (growth arrest and DNAdamage) family proteins in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme-1),which controls cell proliferation and tumor growth as a central mediator of endoplasmic reticulum stress.We have shown that hypoxia up-regulates the expression of GADD34, GADD45A, GADD45B, and GADD153genes, which are related to cell proliferation and apoptosis, in control (transfected by empty vector) gliomacells in gene specific manner.	gadd	70-74	growth arrest and DNA damage inducible alpha	Homo sapiens	376-383
29227599-1	2016	We have studied hypoxic regulation of the expression of genes encoded GADD (growth arrest and DNAdamage) family proteins in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme-1),which controls cell proliferation and tumor growth as a central mediator of endoplasmic reticulum stress.We have shown that hypoxia up-regulates the expression of GADD34, GADD45A, GADD45B, and GADD153genes, which are related to cell proliferation and apoptosis, in control (transfected by empty vector) gliomacells in gene specific manner.	gadd	70-74	growth arrest and DNA damage inducible beta	Homo sapiens	385-392
29227599-1	2016	We have studied hypoxic regulation of the expression of genes encoded GADD (growth arrest and DNAdamage) family proteins in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme-1),which controls cell proliferation and tumor growth as a central mediator of endoplasmic reticulum stress.We have shown that hypoxia up-regulates the expression of GADD34, GADD45A, GADD45B, and GADD153genes, which are related to cell proliferation and apoptosis, in control (transfected by empty vector) gliomacells in gene specific manner.	gadd	70-74	DNA damage inducible transcript 3	Homo sapiens	398-405
26116417-4	2015	Based on our results, the major effect from plasma exposure was found to be the activation of MAPK and p53 signaling pathways, resulting in changes in gene expression of MEKK, GADD, FOS and JUN.	gadd	176-180	tumor protein p53	Homo sapiens	103-106
26196182-1	2015	BACKGROUND: Growth arrest and DNA damage-inducible protein 34 (GADD34/Ppp1r15a) is a family of GADD proteins that are induced by DNA damage.	gadd	63-67	protein phosphatase 1, regulatory subunit 15A	Mus musculus	12-61
26196182-1	2015	BACKGROUND: Growth arrest and DNA damage-inducible protein 34 (GADD34/Ppp1r15a) is a family of GADD proteins that are induced by DNA damage.	gadd	63-67	protein phosphatase 1, regulatory subunit 15A	Mus musculus	70-78
22223508-5	2014	Our data reaffirms the oncogenic capability of MIC with elevated DNA damage response proteins pATM and gamma-H2AX, deregulation of DNA damage check point genes CHK1 and CHK2, altered expression of p53 and p21 proteins involved in cell cycle arrest with perturbation in GADD-45 expression in the treated cells.	gadd	269-273	tumor protein p53	Homo sapiens	197-200
22340178-12	2011	Western blotting analysis showed that C6ORF120 recombinant protein increased the expression of GRp78 and GADD in Jurkat cells in vitro.	gadd	105-109	chromosome 6 open reading frame 120	Homo sapiens	38-46
24282278-8	2014	Moreover, His-MDA-7, after binding to its cognate receptors (IL-20R1/IL-20R2 or IL-22R/IL-20R2), induces intracellular signaling by phosphorylation of p38 MAPK, leading to transcription of a family of growth arrest and DNA damage inducible (GADD) genes, culminating in apoptosis.	gadd	241-245	interleukin 24	Homo sapiens	14-19
24282278-8	2014	Moreover, His-MDA-7, after binding to its cognate receptors (IL-20R1/IL-20R2 or IL-22R/IL-20R2), induces intracellular signaling by phosphorylation of p38 MAPK, leading to transcription of a family of growth arrest and DNA damage inducible (GADD) genes, culminating in apoptosis.	gadd	241-245	interleukin 20 receptor subunit alpha	Homo sapiens	61-68
24282278-8	2014	Moreover, His-MDA-7, after binding to its cognate receptors (IL-20R1/IL-20R2 or IL-22R/IL-20R2), induces intracellular signaling by phosphorylation of p38 MAPK, leading to transcription of a family of growth arrest and DNA damage inducible (GADD) genes, culminating in apoptosis.	gadd	241-245	interleukin 20 receptor subunit beta	Homo sapiens	69-76
24282278-8	2014	Moreover, His-MDA-7, after binding to its cognate receptors (IL-20R1/IL-20R2 or IL-22R/IL-20R2), induces intracellular signaling by phosphorylation of p38 MAPK, leading to transcription of a family of growth arrest and DNA damage inducible (GADD) genes, culminating in apoptosis.	gadd	241-245	interleukin 22 receptor subunit alpha 1	Homo sapiens	80-86
24282278-8	2014	Moreover, His-MDA-7, after binding to its cognate receptors (IL-20R1/IL-20R2 or IL-22R/IL-20R2), induces intracellular signaling by phosphorylation of p38 MAPK, leading to transcription of a family of growth arrest and DNA damage inducible (GADD) genes, culminating in apoptosis.	gadd	241-245	interleukin 20 receptor subunit beta	Homo sapiens	87-94