PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27481561-4	2016	In the course of building on a strong foundation of SAR and creating a novel chemical tool for target identification of homoisoflavonoid-binding proteins, various types of photoaffinity probes were designed and synthesized in which benzophenone and biotin were attached to homoisoflavanonoids using PEG linkers on either the C-3" or C-7 position.	benzophenone	232-244	sarcosine dehydrogenase	Homo sapiens	52-55
27318976-2	2016	Based on this indole-2-carboxamide scaffold, we designed and synthesized novel CB1 allosteric modulators that possess photoactivatable functionalities, which include benzophenone, phenyl azide, aliphatic azide and phenyltrifluoromethyldiazrine.	benzophenone	166-178	cannabinoid receptor 1	Homo sapiens	79-82
26135519-3	2015	DFT calculations suggest that the mechanism of formation for the silaoxiranyl complex Cp*(IXy)(H)2Ru-Si(OCPh2)Trip (6) involves coordination of benzophenone to a silylene silicon atom, followed by a single-electron transfer in which Si-bonded, non-innocent benzophenone accepts an electron from the reactive, electron-rich ruthenium center.	benzophenone	144-156	TRAF interacting protein	Homo sapiens	110-114
27101427-2	2016	The surface of polypropylene pipet tip was activated by the photoinitiator benzophenone under UV light radiation followed by polymerization of ethylene glycol methacrylate phosphate and bis-acrylamide in the tip to form a porous monolith with reactive phosphate groups.	benzophenone	75-87	TOR signaling pathway regulator	Homo sapiens	35-38
27101427-2	2016	The surface of polypropylene pipet tip was activated by the photoinitiator benzophenone under UV light radiation followed by polymerization of ethylene glycol methacrylate phosphate and bis-acrylamide in the tip to form a porous monolith with reactive phosphate groups.	benzophenone	75-87	TOR signaling pathway regulator	Homo sapiens	208-211
26965011-6	2016	It has been found that benzophenone-2 (BP-2), BP-3, 4-methylbenzophenone (4-MBP) and OMC present in the culture medium for 72h in high concentration (10(-5) and 10(-4)M) and 4-MBC only 10(-4)M produced a significant cytotoxic effect, as determined both by the MTT reduction test and LDH release assay.	benzophenone	23-35	myelin basic protein	Homo sapiens	76-79
26747437-4	2016	The results indicated butyl-methoxydibenzoylmethane, octyl-dimethyl-PABA and benzophenone-types (BP3, BP4 and BP1) were the most frequently detected compounds at concentrations of 3.63-104 ng/L.	benzophenone	77-89	BP3	Homo sapiens	97-100
26747437-4	2016	The results indicated butyl-methoxydibenzoylmethane, octyl-dimethyl-PABA and benzophenone-types (BP3, BP4 and BP1) were the most frequently detected compounds at concentrations of 3.63-104 ng/L.	benzophenone	77-89	BP4	Homo sapiens	102-105
26747437-4	2016	The results indicated butyl-methoxydibenzoylmethane, octyl-dimethyl-PABA and benzophenone-types (BP3, BP4 and BP1) were the most frequently detected compounds at concentrations of 3.63-104 ng/L.	benzophenone	77-89	BP1	Homo sapiens	110-113
26690799-2	2016	We have designed and synthesized three novel host materials, i.e., BP2-BP4, which contain benzophenone as the active triplet sensitizing molecular component.	benzophenone	90-102	BP2	Homo sapiens	67-74
26135519-3	2015	DFT calculations suggest that the mechanism of formation for the silaoxiranyl complex Cp*(IXy)(H)2Ru-Si(OCPh2)Trip (6) involves coordination of benzophenone to a silylene silicon atom, followed by a single-electron transfer in which Si-bonded, non-innocent benzophenone accepts an electron from the reactive, electron-rich ruthenium center.	benzophenone	257-269	TRAF interacting protein	Homo sapiens	110-114
27155137-10	2016	The correlation was observed between urinary concentrations of BP derivatives, which is an important indication of exposure biomarkers and the metabolic pathways from BP-3.	benzophenone	63-65	BP3	Homo sapiens	167-171
26874345-0	2016	Synthesis and antiproliferative activity of benzophenone tagged pyridine analogues towards activation of caspase activated DNase mediated nuclear fragmentation in Dalton"s lymphoma.	benzophenone	44-56	DNA fragmentation factor, beta subunit	Mus musculus	105-128
26115577-0	2015	Synthesis and biological evaluation of N-cyclopropylbenzamide-benzophenone hybrids as novel and selective p38 mitogen activated protein kinase (MAPK) inhibitors.	benzophenone	62-74	mitogen-activated protein kinase 14	Homo sapiens	106-142
25800561-0	2015	Role of type I & type II reactions in DNA damage and activation of caspase 3 via mitochondrial pathway induced by photosensitized benzophenone.	benzophenone	134-146	caspase 3	Homo sapiens	71-80
25795606-1	2015	Although 4-aminobenzophenone (4-ABP) is the best derivative of benzophenone with 260 times higher second harmonic generation (SHG) efficiency than potassium dihydrogen phosphate (KDP), growth of high quality bulk crystal still remains a difficult task.	benzophenone	16-28	amine oxidase copper containing 1	Homo sapiens	32-35
25016280-5	2014	Here we describe the use of benzophenone (BP) photolithography to decorate three-dimensional collagen-glycosaminoglycan (CG) scaffolds with VEGF in a spatially defined manner.	benzophenone	28-40	vascular endothelial growth factor A	Homo sapiens	140-144
25058749-2	2014	Tp*2U(OC Ph2) is a potent two-electron reductant towards N3Mes (Mes = 2,4,6-trimethylphenyl) and (2,2,6,6-tetramethyl-piperidin-1-yl)oxyl (TEMPO), with reducing equivalents derived from the metal centre and the redox-active benzophenone.	benzophenone	224-236	polyhomeotic homolog 2	Homo sapiens	9-12
25016280-5	2014	Here we describe the use of benzophenone (BP) photolithography to decorate three-dimensional collagen-glycosaminoglycan (CG) scaffolds with VEGF in a spatially defined manner.	benzophenone	42-44	vascular endothelial growth factor A	Homo sapiens	140-144
23328252-1	2013	2,4-Dihydroxybenzophenone (benzophenone-1; BP-1) is an UV stabilizer primarily used to prevent polymer degradation and deterioration in quality due to UV irradiation.	benzophenone	13-25	BP1	Homo sapiens	43-47
24502619-7	2014	This multifuctional diazirine-containing peptide was a substrate for Ste14p, the yeast homologue of the potential anticancer target Icmt, with K(m) (6.6 muM) and V(max) (947 pmol min(-1) mg(-1)) values comparable or better than a-factor peptides functionalized with benzophenone-based isoprenoids.	benzophenone	266-278	protein-S-isoprenylcysteine carboxyl O-methyltransferase	Saccharomyces cerevisiae S288C	69-75
23432317-3	2014	Noteworthy, stilbene and benzophenone branched derivatives activated the PPARalpha better than clofibric acid.	benzophenone	25-37	peroxisome proliferator activated receptor alpha	Homo sapiens	73-82
24231334-0	2013	Molecular interactions of benzophenone UV filters with human serum albumin revealed by spectroscopic techniques and molecular modeling.	benzophenone	26-38	albumin	Homo sapiens	61-74
25315970-2	2014	To achieve this, a GSH analogue (GSH-BP) was designed and chemically synthesized with three functionalities: (1) the binding affinity of GSH to GST, (2) a free thiol for polymer functionalization, and (3) a photoreactive benzophenone (BP) component.	benzophenone	37-39	glutathione S-transferase kappa 1	Homo sapiens	144-147
25315970-7	2014	Results showed that both GSH and BP were crucial for successful conjugation to GST.	benzophenone	33-35	glutathione S-transferase kappa 1	Homo sapiens	79-82
25002233-5	2014	In addition, the results from cytotoxicity studies with human colon adenocarcinoma cells showed low LC50 values for benzophenone 6 and its N-acyl hydrazone analogue 14 (31.4 +- 0.4 muM and 87 +- 1.9 muM, respectively), in addition to the strong enzyme inhibition profile (IC50(6)=1,77 +- 0.10 muM; IC50(14)=0.33 +- 0.05 muM).	benzophenone	116-128	latexin	Homo sapiens	181-184
24681980-1	2014	In an effort to develop multipotent agents against beta-secretase (BACE-1) and acetylcholinesterase (AChE), able to counteract intracellular ROS formation as well, the structure of the fluorinated benzophenone 3 served as starting point for the synthesis of a small library of 3-fluoro-4-hydroxy- analogues.	benzophenone	197-209	beta-secretase 1	Homo sapiens	67-73
24681980-1	2014	In an effort to develop multipotent agents against beta-secretase (BACE-1) and acetylcholinesterase (AChE), able to counteract intracellular ROS formation as well, the structure of the fluorinated benzophenone 3 served as starting point for the synthesis of a small library of 3-fluoro-4-hydroxy- analogues.	benzophenone	197-209	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-99
24681980-1	2014	In an effort to develop multipotent agents against beta-secretase (BACE-1) and acetylcholinesterase (AChE), able to counteract intracellular ROS formation as well, the structure of the fluorinated benzophenone 3 served as starting point for the synthesis of a small library of 3-fluoro-4-hydroxy- analogues.	benzophenone	197-209	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-105
24599599-3	2014	The inhibitory effects of diphenylmethanone derivatives 5-18 were tested on human CA (hCA, EC 4.2.1.1) isoenzymes (hCA I and hCA II) and they inhibited both isoenzymes at micromolar levels.	benzophenone	26-43	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	115-131
22584684-5	2012	The three nuclear receptor-activating chemicals (phenobarbital, benzophenone, and diethylhexylphthalate) were characterized by the highly correlated induction of the miR-200a/200b/429, which is involved in protecting the epithelial status of cells and of the miR-96/182 clusters.	benzophenone	64-76	microRNA 200a	Rattus norvegicus	166-174
22584684-5	2012	The three nuclear receptor-activating chemicals (phenobarbital, benzophenone, and diethylhexylphthalate) were characterized by the highly correlated induction of the miR-200a/200b/429, which is involved in protecting the epithelial status of cells and of the miR-96/182 clusters.	benzophenone	64-76	microRNA 96	Rattus norvegicus	259-265
22634004-3	2012	Herein, we evaluated synthetic analogs of two well-characterized Icmt substrates, N-acetyl-S-farnesyl-L-cysteine (AFC) and the yeast a-factor peptide mating pheromone, that contain photoactive benzophenone moieties in either the lipid or peptide portion of the molecule.	benzophenone	193-205	isoprenylcysteine carboxyl methyltransferase	Homo sapiens	65-69
22197420-0	2012	Studying protein-peptide interactions using benzophenone units: a case study of protein kinase B/Akt and its inhibitor PTR6154.	benzophenone	44-56	protein tyrosine kinase 2 beta	Homo sapiens	80-96
22459212-0	2012	Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton.	benzophenone	72-84	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	51-55
22459212-1	2012	A series of novel benzophenone derivatives were prepared and their inhibitory activities were evaluated on hPin1.	benzophenone	18-30	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	107-112
22764574-0	2012	Arginine 485 of human serum albumin interacts with the benzophenone moiety of ketoprofen in the binding pocket of subdomain III A and III B.	benzophenone	55-67	albumin	Homo sapiens	22-35
22452412-0	2012	Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.	benzophenone	91-103	ATP binding cassette subfamily B member 1	Homo sapiens	149-163
22452412-2	2012	Here we synthesized and tested a series of benzophenone derivatives structurally analogous to propafenone-type inhibitors of P-gp.	benzophenone	43-55	ATP binding cassette subfamily B member 1	Homo sapiens	125-129
22197420-0	2012	Studying protein-peptide interactions using benzophenone units: a case study of protein kinase B/Akt and its inhibitor PTR6154.	benzophenone	44-56	AKT serine/threonine kinase 1	Homo sapiens	97-100
21353545-2	2011	A structure-activity relationship study of 2,4-diaminothiazole inhibitors revealed that increased Cdk5/p25 inhibitory activity could be accomplished by incorporating pyridines on the 2-amino group and addition of substituents to the 2- or 3-position of the phenyl ketone moiety.	benzophenone	257-270	cyclin-dependent kinase 5	Mus musculus	98-102
22952682-4	2012	Using benzophenone-bearing hydroxamate-based probes that interact with the catalytic zinc ion in MMPs, active proteases can be covalently "tagged" by UV cross-linking.	benzophenone	6-18	matrix metallopeptidase 2	Danio rerio	97-101
21353545-2	2011	A structure-activity relationship study of 2,4-diaminothiazole inhibitors revealed that increased Cdk5/p25 inhibitory activity could be accomplished by incorporating pyridines on the 2-amino group and addition of substituents to the 2- or 3-position of the phenyl ketone moiety.	benzophenone	257-270	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	103-106
21088910-0	2011	Studies on the interaction between benzophenone and bovine serum albumin by spectroscopic methods.	benzophenone	35-47	albumin	Homo sapiens	59-72
20207143-0	2010	Synthesis and biological evaluation of nitrogen-containing benzophenone analogues as TNF-alpha and IL-6 inhibitors with antioxidant activity.	benzophenone	59-71	tumor necrosis factor	Homo sapiens	85-94
21088910-1	2011	The interaction between benzophenone (BP) and bovine serum albumin (BSA) was investigated by the methods of fluorescence spectroscopy combined with UV-Vis absorption and circular dichroism (CD) measurements under simulative physiological conditions.	benzophenone	24-36	albumin	Homo sapiens	53-66
21088910-1	2011	The interaction between benzophenone (BP) and bovine serum albumin (BSA) was investigated by the methods of fluorescence spectroscopy combined with UV-Vis absorption and circular dichroism (CD) measurements under simulative physiological conditions.	benzophenone	38-40	albumin	Homo sapiens	53-66
20933415-0	2010	Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L.	benzophenone	15-27	cathepsin L	Homo sapiens	110-121
20933415-5	2010	The two most active analogs in the benzophenone thiosemicarbazone series are highly selective for their inhibition of cathepsin L versus cathepsin B.	benzophenone	35-47	cathepsin L	Homo sapiens	118-129
20933415-5	2010	The two most active analogs in the benzophenone thiosemicarbazone series are highly selective for their inhibition of cathepsin L versus cathepsin B.	benzophenone	35-47	cathepsin B	Homo sapiens	137-148
20619662-0	2010	Photoaffinity labeling of Ras converting enzyme 1 (Rce1p) using a benzophenone-containing peptide substrate.	benzophenone	66-78	Ras converting CAAX endopeptidase 1	Homo sapiens	51-56
20619662-4	2010	Here, we describe the synthesis of a benzophenone-containing peptide substrate analogue for Rce1p.	benzophenone	37-49	Ras converting CAAX endopeptidase 1	Homo sapiens	92-97
20005209-5	2010	Among other chemicals, benzophenone (BP) UV-filters were predicted as potential 17beta-HSD3 inhibitors.	benzophenone	23-35	hydroxysteroid 17-beta dehydrogenase 3	Homo sapiens	80-91
20005209-5	2010	Among other chemicals, benzophenone (BP) UV-filters were predicted as potential 17beta-HSD3 inhibitors.	benzophenone	37-39	hydroxysteroid 17-beta dehydrogenase 3	Homo sapiens	80-91
20373302-2	2010	We evaluated in vitro and in cell the ability of eleven natural polyisoprenylated benzophenone derivatives to modulate the HAT activity of p300/CBP, an enzyme that plays a pivotal role in a variety of cellular processes.	benzophenone	82-94	E1A binding protein p300	Homo sapiens	139-143
20373302-2	2010	We evaluated in vitro and in cell the ability of eleven natural polyisoprenylated benzophenone derivatives to modulate the HAT activity of p300/CBP, an enzyme that plays a pivotal role in a variety of cellular processes.	benzophenone	82-94	CREB binding protein	Homo sapiens	144-147
20207143-0	2010	Synthesis and biological evaluation of nitrogen-containing benzophenone analogues as TNF-alpha and IL-6 inhibitors with antioxidant activity.	benzophenone	59-71	interleukin 6	Homo sapiens	99-103
20089402-1	2010	A small library of 36 functionalized benzophenone thiosemicarbazone analogs has been prepared by chemical synthesis and evaluated for their ability to inhibit the cysteine proteases cathepsin L and cathepsin B.	benzophenone	37-49	cathepsin L	Homo sapiens	182-193
20089402-1	2010	A small library of 36 functionalized benzophenone thiosemicarbazone analogs has been prepared by chemical synthesis and evaluated for their ability to inhibit the cysteine proteases cathepsin L and cathepsin B.	benzophenone	37-49	cathepsin B	Homo sapiens	198-209
19266268-0	2009	Anti-androgen receptor signaling and prostate cancer inhibitory effects of sucrose- and benzophenone-compounds.	benzophenone	88-100	androgen receptor	Homo sapiens	5-22
19664474-5	2009	In this study we show that synthetic benzophenone analogue, 2-benzoyl-phenoxy acetamide (BP-1) can act as a novel anti-arthritic agent in an experimental adjuvant induced arthritis (AIA) rat model by targeting VEGF and HIF-1alpha.	benzophenone	37-49	Blood pressure QTL 1	Rattus norvegicus	89-93
19664474-5	2009	In this study we show that synthetic benzophenone analogue, 2-benzoyl-phenoxy acetamide (BP-1) can act as a novel anti-arthritic agent in an experimental adjuvant induced arthritis (AIA) rat model by targeting VEGF and HIF-1alpha.	benzophenone	37-49	vascular endothelial growth factor A	Rattus norvegicus	210-214
19664474-5	2009	In this study we show that synthetic benzophenone analogue, 2-benzoyl-phenoxy acetamide (BP-1) can act as a novel anti-arthritic agent in an experimental adjuvant induced arthritis (AIA) rat model by targeting VEGF and HIF-1alpha.	benzophenone	37-49	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	219-229
19266268-9	2009	The benzophenone compound 2-methoxy-3,4-(methylenedioxy)benzophenone suppressed PSA and AR in LNCaP cells without apoptosis.	benzophenone	4-16	androgen receptor	Homo sapiens	88-90
19266268-9	2009	The benzophenone compound 2-methoxy-3,4-(methylenedioxy)benzophenone suppressed PSA and AR in LNCaP cells without apoptosis.	benzophenone	4-16	kallikrein related peptidase 3	Homo sapiens	80-83
19053130-4	2009	With the use of the benzophenone-modified cisplatin analogue Pt-BP6, 25 bp DNA duplexes containing either a 1,2-d(G*pG*) intrastrand or a 1,3-d(G*pTpG*) intrastrand crosslink were synthesized, where the asterisks designate platinated nucleobases.	benzophenone	20-32	BP6	Homo sapiens	64-67
18921987-3	2008	The T 1(pi,pi*) states of PP-X were efficiently produced during 355-nm laser photolysis of benzophenone as a triplet sensitizer.	benzophenone	91-103	protein phosphatase 4 catalytic subunit	Homo sapiens	26-30
18706922-0	2008	Profiling of benzophenone derivatives using fish and human estrogen receptor-specific in vitro bioassays.	benzophenone	13-25	estrogen receptor 1	Homo sapiens	59-76
18706922-5	2008	All BP derivatives tested except BP3 were full hERalpha and hERbeta agonists (BP2>THB>BP1) and displayed a stronger activation of hERbeta compared with hERalpha, the opposite effect to that of estradiol (E2).	benzophenone	4-6	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	47-55
18706922-5	2008	All BP derivatives tested except BP3 were full hERalpha and hERbeta agonists (BP2>THB>BP1) and displayed a stronger activation of hERbeta compared with hERalpha, the opposite effect to that of estradiol (E2).	benzophenone	4-6	estrogen receptor 2	Homo sapiens	60-67
18706922-5	2008	All BP derivatives tested except BP3 were full hERalpha and hERbeta agonists (BP2>THB>BP1) and displayed a stronger activation of hERbeta compared with hERalpha, the opposite effect to that of estradiol (E2).	benzophenone	4-6	BP2	Homo sapiens	78-81
18706922-5	2008	All BP derivatives tested except BP3 were full hERalpha and hERbeta agonists (BP2>THB>BP1) and displayed a stronger activation of hERbeta compared with hERalpha, the opposite effect to that of estradiol (E2).	benzophenone	4-6	BP1	Homo sapiens	92-95
18706922-5	2008	All BP derivatives tested except BP3 were full hERalpha and hERbeta agonists (BP2>THB>BP1) and displayed a stronger activation of hERbeta compared with hERalpha, the opposite effect to that of estradiol (E2).	benzophenone	4-6	estrogen receptor 2	Homo sapiens	136-143
18706922-5	2008	All BP derivatives tested except BP3 were full hERalpha and hERbeta agonists (BP2>THB>BP1) and displayed a stronger activation of hERbeta compared with hERalpha, the opposite effect to that of estradiol (E2).	benzophenone	4-6	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	158-166
17715970-1	2007	A nanosecond time-resolved resonance Raman (ns-TR3) spectroscopic study of the triplet state benzophenone reaction with the 2-propanol hydrogen-donor solvent and subsequent reactions is presented.	benzophenone	93-105	nuclear receptor subfamily 4 group A member 1	Homo sapiens	47-50
18799314-6	2008	In order to gain an insight into this problem, we conducted a structure-activity relationship (SAR) study of benzophenone photoligands for Lck kinase, in which photoligands with varying target-binding affinity and conformational flexibility were compared.	benzophenone	109-121	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	139-142
18242814-1	2008	Twelve derivatives of benzophenone (BP1-BP12) are widely used as UV-screens to protect industrial products from light induced damage.	benzophenone	22-34	Blood pressure QTL 1	Rattus norvegicus	36-39
18154275-1	2008	The well-known benzophenone intersystem crossing from S(1)(n,pi*) to T(1)(n,pi*) states, for which direct transition is forbidden by El-Sayed rules, is reinvestigated by subpicosecond time-resolved absorption spectroscopy and effective data analysis for various excitation wavelengths and solvents.	benzophenone	15-27	proteasome 26S subunit, non-ATPase 1	Homo sapiens	54-58
18844293-6	2008	A proof of concept for the use of benzophenone protection has been established by the synthesis of an aza-peptide analog of a potent activator of caspase 9 in cancer cells.	benzophenone	34-46	caspase 9	Homo sapiens	146-155
17975887-10	2007	Finally, bioactivation of 2-hydroxy-4-methoxybenzophenone (benzophenone-3) into ERalpha-binding metabolites by P450 was studied using the validated P450-bioreactor-SPE-HPLC-ERAD system in combination with atmospheric pressure chemical ionization MS.	benzophenone	45-57	estrogen receptor 1	Homo sapiens	80-87
17914813-2	2007	Thus reaction with benzophenone gave [Sm(Tp(Me2))2(OCPh2)], 2, with fluorenone [Sm(Tp(Me2))2(eta1-OC13H8)], 3, and di-tert-butylparaquinone [Sm(Tp(Me2))2(eta1-OC6H2(tBu)2O)], 4, each of which was structurally characterized.	benzophenone	19-31	secreted phosphoprotein 1	Homo sapiens	93-97
17914813-2	2007	Thus reaction with benzophenone gave [Sm(Tp(Me2))2(OCPh2)], 2, with fluorenone [Sm(Tp(Me2))2(eta1-OC13H8)], 3, and di-tert-butylparaquinone [Sm(Tp(Me2))2(eta1-OC6H2(tBu)2O)], 4, each of which was structurally characterized.	benzophenone	19-31	secreted phosphoprotein 1	Homo sapiens	154-158
18706922-7	2008	All four BP derivatives showed anti-androgenic activity (THB>BP2>BP1>BP3).	benzophenone	9-11	BP2	Homo sapiens	64-67
18706922-7	2008	All four BP derivatives showed anti-androgenic activity (THB>BP2>BP1>BP3).	benzophenone	9-11	BP1	Homo sapiens	71-74
18706922-7	2008	All four BP derivatives showed anti-androgenic activity (THB>BP2>BP1>BP3).	benzophenone	9-11	BP3	Homo sapiens	78-81
18706922-8	2008	Overall, the observed anti-androgenic potencies of BP derivatives, together with their proposed greater effect on ERbeta versus ERalpha activation, support further investigation of their role as endocrine disrupters in humans and wildlife.	benzophenone	51-53	estrogen receptor 2	Homo sapiens	114-120
18706922-8	2008	Overall, the observed anti-androgenic potencies of BP derivatives, together with their proposed greater effect on ERbeta versus ERalpha activation, support further investigation of their role as endocrine disrupters in humans and wildlife.	benzophenone	51-53	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	128-135
18367444-6	2008	DHBP represents a benzophenone scaffold binding in the CYP51 active site via a type I mechanism, suggesting (i) a possible new class of CYP51 inhibitors targeting flexible regions, (ii) an alternative catalytic function for bacterial CYP51 enzymes, and (iii) a potential for hydroxybenzophenones, widely distributed in the environment, to interfere with sterol biosynthesis.	benzophenone	18-30	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	55-60
18367444-6	2008	DHBP represents a benzophenone scaffold binding in the CYP51 active site via a type I mechanism, suggesting (i) a possible new class of CYP51 inhibitors targeting flexible regions, (ii) an alternative catalytic function for bacterial CYP51 enzymes, and (iii) a potential for hydroxybenzophenones, widely distributed in the environment, to interfere with sterol biosynthesis.	benzophenone	18-30	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	136-141
18367444-6	2008	DHBP represents a benzophenone scaffold binding in the CYP51 active site via a type I mechanism, suggesting (i) a possible new class of CYP51 inhibitors targeting flexible regions, (ii) an alternative catalytic function for bacterial CYP51 enzymes, and (iii) a potential for hydroxybenzophenones, widely distributed in the environment, to interfere with sterol biosynthesis.	benzophenone	18-30	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	136-141
17715970-2	2007	The TR3 spectra show that the benzophenone triplet state (npi*) hydrogen-abstraction reaction with 2-propanol is very fast (about 10 to 20 ns) and forms a diphenylketyl radical and an associated 2-propanol radical partner.	benzophenone	30-42	nuclear receptor subfamily 4 group A member 1	Homo sapiens	4-7
17600857-3	2007	The three-dimensional binding environment of the human angiotensin II type 1 receptor hAT(1) has been determined using an iterative methionine mutagenesis strategy based on the photochemical properties and preferential incorporation of benzophenone onto methionine.	benzophenone	236-248	angiotensin II receptor type 1	Homo sapiens	86-92
17600857-6	2007	The hAT(1) receptor and two representative Met mutants (H256M-hAT(1) and F293M-hAT(1)) from the iterative mutagenesis study were photolabelled with the benzophenone-ligand (125)I-[Sar(1), Bpa(8)]AngII at temperatures ranging from - 15 degrees C to 37 degrees C. Labelled receptors were partially purified and digested with cyanogen bromide to identify the contact points or segments.	benzophenone	152-164	angiotensin II receptor type 1	Homo sapiens	4-10
17585752-2	2007	Starting from an easy, synthetically accessible, benzophenone scaffold, a new class of potent aromatase inhibitors was synthesized, endowed with high selectivity with respect to 17 alpha-hydroxylase/17,20-lyase (CYP17).	benzophenone	49-61	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	212-217
16598818-2	2006	In the present study, we have shown that some EDC [benzophenone, p-octylphenol, and tributyltin chloride (TBT)] promoted strong Th2 polarization via suppression and augmentation of Th1 and Th2 development, respectively, from naive CD4+ T cells primed with anti-CD3 and splenic antigen-presenting cells (APC).	benzophenone	51-63	heart and neural crest derivatives expressed 2	Mus musculus	128-131
16938874-7	2006	The high selectivity of phenyl ketone 1 for AKR1C2 over the many endogenous reductases present in mammalian cells was established by a quantitative comparison of the metabolic rates between null control cells (COS-1) and AKR1C2-transfected cells.	benzophenone	24-37	aldo-keto reductase family 1 member C2	Homo sapiens	44-50
16938874-7	2006	The high selectivity of phenyl ketone 1 for AKR1C2 over the many endogenous reductases present in mammalian cells was established by a quantitative comparison of the metabolic rates between null control cells (COS-1) and AKR1C2-transfected cells.	benzophenone	24-37	aldo-keto reductase family 1 member C2	Homo sapiens	221-227
16938874-8	2006	Phenyl ketone 1 is a cell-permeable fluorogenic probe that permits a direct, real-time, and operationally simple readout of AKR1C2 enzyme activity in intact mammalian cells.	benzophenone	0-13	aldo-keto reductase family 1 member C2	Homo sapiens	124-130
17379648-0	2007	The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase.	benzophenone	23-35	thyroid peroxidase	Homo sapiens	143-161
17309226-3	2007	A fluorine-substituted PPARgamma ligand from tyrosine-benzophenone class, compound 1, has a very high affinity for PPARgamma receptor (Ki = 0.14 nM).	benzophenone	54-66	peroxisome proliferator activated receptor gamma	Homo sapiens	23-32
17309226-3	2007	A fluorine-substituted PPARgamma ligand from tyrosine-benzophenone class, compound 1, has a very high affinity for PPARgamma receptor (Ki = 0.14 nM).	benzophenone	54-66	peroxisome proliferator activated receptor gamma	Homo sapiens	115-124
17315977-2	2007	To develop agents for radionuclide imaging PPARgamma in vivo, we synthesized fluorine, bromine, and iodine-substituted analogs (1-3) of a high-affinity benzophenone-tyrosine PPARgamma ligand; all three analogs retain very high affinity for the PPARgamma receptor.	benzophenone	152-164	peroxisome proliferator activated receptor gamma	Homo sapiens	43-52
17315977-2	2007	To develop agents for radionuclide imaging PPARgamma in vivo, we synthesized fluorine, bromine, and iodine-substituted analogs (1-3) of a high-affinity benzophenone-tyrosine PPARgamma ligand; all three analogs retain very high affinity for the PPARgamma receptor.	benzophenone	152-164	peroxisome proliferator activated receptor gamma	Homo sapiens	174-183
17315977-2	2007	To develop agents for radionuclide imaging PPARgamma in vivo, we synthesized fluorine, bromine, and iodine-substituted analogs (1-3) of a high-affinity benzophenone-tyrosine PPARgamma ligand; all three analogs retain very high affinity for the PPARgamma receptor.	benzophenone	152-164	peroxisome proliferator activated receptor gamma	Homo sapiens	174-183
16598437-2	2006	Synthetic benzophenone analogue 2-benzoyl -phenoxy acetamide (BP-1) is proven to be potent antitumor and proapoptotic activity against EAT cells in-vivo.	benzophenone	10-22	BP1	Homo sapiens	62-66
16820853-2	2006	Laser-induced room temperature luminescence of argon purged solid powdered samples of benzophenone adsorbed onto the two different reversed-phase silicas, RP-18 and RP-8, revealed the existence of a low energy emission band in contrast with the benzophenone adsorbed on 60 A pore silica, where only triplet benzophenone emits.	benzophenone	86-98	pre-mRNA processing factor 3	Homo sapiens	155-160
16820853-2	2006	Laser-induced room temperature luminescence of argon purged solid powdered samples of benzophenone adsorbed onto the two different reversed-phase silicas, RP-18 and RP-8, revealed the existence of a low energy emission band in contrast with the benzophenone adsorbed on 60 A pore silica, where only triplet benzophenone emits.	benzophenone	86-98	programmed cell death 2	Homo sapiens	165-169
16820853-2	2006	Laser-induced room temperature luminescence of argon purged solid powdered samples of benzophenone adsorbed onto the two different reversed-phase silicas, RP-18 and RP-8, revealed the existence of a low energy emission band in contrast with the benzophenone adsorbed on 60 A pore silica, where only triplet benzophenone emits.	benzophenone	245-257	pre-mRNA processing factor 3	Homo sapiens	155-160
16820853-2	2006	Laser-induced room temperature luminescence of argon purged solid powdered samples of benzophenone adsorbed onto the two different reversed-phase silicas, RP-18 and RP-8, revealed the existence of a low energy emission band in contrast with the benzophenone adsorbed on 60 A pore silica, where only triplet benzophenone emits.	benzophenone	245-257	programmed cell death 2	Homo sapiens	165-169
16820853-2	2006	Laser-induced room temperature luminescence of argon purged solid powdered samples of benzophenone adsorbed onto the two different reversed-phase silicas, RP-18 and RP-8, revealed the existence of a low energy emission band in contrast with the benzophenone adsorbed on 60 A pore silica, where only triplet benzophenone emits.	benzophenone	245-257	pre-mRNA processing factor 3	Homo sapiens	155-160
16820853-2	2006	Laser-induced room temperature luminescence of argon purged solid powdered samples of benzophenone adsorbed onto the two different reversed-phase silicas, RP-18 and RP-8, revealed the existence of a low energy emission band in contrast with the benzophenone adsorbed on 60 A pore silica, where only triplet benzophenone emits.	benzophenone	245-257	programmed cell death 2	Homo sapiens	165-169
16598818-2	2006	In the present study, we have shown that some EDC [benzophenone, p-octylphenol, and tributyltin chloride (TBT)] promoted strong Th2 polarization via suppression and augmentation of Th1 and Th2 development, respectively, from naive CD4+ T cells primed with anti-CD3 and splenic antigen-presenting cells (APC).	benzophenone	51-63	negative elongation factor complex member C/D, Th1l	Mus musculus	181-184
16598818-2	2006	In the present study, we have shown that some EDC [benzophenone, p-octylphenol, and tributyltin chloride (TBT)] promoted strong Th2 polarization via suppression and augmentation of Th1 and Th2 development, respectively, from naive CD4+ T cells primed with anti-CD3 and splenic antigen-presenting cells (APC).	benzophenone	51-63	heart and neural crest derivatives expressed 2	Mus musculus	189-192
16598818-7	2006	Collectively these results suggest that EDC such as benzophenone, p-octylphenol, and TBT promote Th2 polarization indirectly via the depletion of glutathione in APC and subsequent modulation of IL-10 and IL-12 production that might result in the exacerbation of allergic diseases.	benzophenone	52-64	heart and neural crest derivatives expressed 2	Mus musculus	97-100
16598818-7	2006	Collectively these results suggest that EDC such as benzophenone, p-octylphenol, and TBT promote Th2 polarization indirectly via the depletion of glutathione in APC and subsequent modulation of IL-10 and IL-12 production that might result in the exacerbation of allergic diseases.	benzophenone	52-64	interleukin 10	Mus musculus	194-199
16321358-0	2006	Photoaffinity labeling of P450Cam by an imidazole-tethered benzophenone probe.	benzophenone	59-71	calmodulin 3	Homo sapiens	30-33
16594669-4	2006	To illustrate the utility of this labeling, we tagged the NF-kappaB p50 transcription factor with benzophenone, cross-linked with UV light, and observed increased levels of p50 homodimerization in the presence of DNA and the binding protein myotrophin.	benzophenone	98-110	nuclear factor kappa B subunit 1	Homo sapiens	68-71
16741556-0	2006	Toxicology and carcinogenesis studies of benzophenone (CAS No.	benzophenone	41-53	BCAR1 scaffold protein, Cas family member	Rattus norvegicus	55-58
16392794-2	2006	New AP-1 inhibitors with a 1-thia-4-azaspiro[4.5]decane or a benzophenone scaffold, which inhibit the DNA-binding and transactivation activities of AP-1, were discovered using a "lead hopping" procedure.	benzophenone	61-73	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-8
16392794-2	2006	New AP-1 inhibitors with a 1-thia-4-azaspiro[4.5]decane or a benzophenone scaffold, which inhibit the DNA-binding and transactivation activities of AP-1, were discovered using a "lead hopping" procedure.	benzophenone	61-73	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	148-152
16392794-3	2006	An additional investigation of the benzophenone analogues confirmed the reliability of the pharmacophore model, its utility to discover AP-1 inhibitors, and the potency of the benzophenone derivatives as a lead series.	benzophenone	35-47	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	136-140
15844964-3	2005	Screening of a natural product library of plant extracts using a LXR-SPA binding assay and bioassay-guided fractionation of the bark and stem extract of Garcinia humilis led to the discovery of a new polyisoprenylated benzophenone named guttiferone I (1).	benzophenone	218-230	surfactant protein A2	Homo sapiens	69-72
15857144-0	2005	Design of benzophenone-containing photoactivatable linear vasopressin antagonists: pharmacological and photoreactive properties.	benzophenone	10-22	arginine vasopressin	Homo sapiens	58-69
15857144-1	2005	We designed and synthesized new photoactivatable linear vasopressin analogues containing benzophenone photophores.	benzophenone	89-101	arginine vasopressin	Homo sapiens	56-67
16169875-4	2005	To understand the structural properties of the singly phosphorylated state, we prepared singly phosphorylated heavy meromyosin (HMM) containing a photoreactive benzophenone-labeled RLC and examined its photocross-linking reactivity.	benzophenone	160-172	integrin subunit alpha 9	Homo sapiens	181-184
15248706-1	2004	Methyl methacrylate/1,2-divinylbenzene (MMA/DVB) in an opaque emulsion were successfully grafted onto the surface of polymeric substrate under the irradiation of UV light with benzophenone (BP) as a photoinitiator that was previously coated on the substrate surface.	benzophenone	176-188	monocyte to macrophage differentiation associated	Homo sapiens	40-47
15456788-5	2004	Moreover, we show that membranes from cells expressing NCT-ER, NCT-TGN, or NCT-WT contain identical levels of PS1 derivatives that can be photoaffinity cross-linked to a biotinylated, benzophenone-derivatized gamma-secretase inhibitor.	benzophenone	184-196	taste 2 receptor member 62 pseudogene	Homo sapiens	110-113
15248706-1	2004	Methyl methacrylate/1,2-divinylbenzene (MMA/DVB) in an opaque emulsion were successfully grafted onto the surface of polymeric substrate under the irradiation of UV light with benzophenone (BP) as a photoinitiator that was previously coated on the substrate surface.	benzophenone	190-192	monocyte to macrophage differentiation associated	Homo sapiens	40-47
14668969-4	2004	Covalent photoadducts of rat CRFBP (rCRFBP) were obtained by PAL with different mono- and bifunctional benzophenone photoprobes designed on the basis of the sequence of the synthetic CRF fragment human/rat CRF(6-33) which binds to CRFBP with high affinity.	benzophenone	103-115	corticotropin releasing hormone binding protein	Rattus norvegicus	36-42
15110857-0	2004	Synthesis, in vitro and in vivo activity of benzophenone-based inhibitors of steroid sulfatase.	benzophenone	44-56	steroid sulfatase	Homo sapiens	77-94
12409231-5	2002	This was achieved by incorporation into a secretin analogue of the radioiodinatable and photolabile benzophenone moiety, p-(4-hydroxybenzoyl)phenylalanine (OH-Bpa).	benzophenone	100-112	secretin	Homo sapiens	42-50
14613717-4	2003	In our study, 7 of 54 xenobiotics compounds interacted with PXR, including methoxychlor and benzophenone.	benzophenone	92-104	nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus	60-63
14690236-3	2003	The quantum yield of the triplet energy-transfer quenching of BP(Tn) by CCl4 was found to be 0.0023 +/- 0.0002 from the bleaching of the transient absorption of BP(T1) and the absorbed photon number.	benzophenone	62-64	C-C motif chemokine ligand 4	Homo sapiens	72-76
14558822-1	2003	A modular strategy for the assembly of farnesylated N-Ras heptapeptides carrying a photoactivatable benzophenone (BP) group within the lipid residue is described.	benzophenone	100-112	NRAS proto-oncogene, GTPase	Homo sapiens	52-57
14558822-1	2003	A modular strategy for the assembly of farnesylated N-Ras heptapeptides carrying a photoactivatable benzophenone (BP) group within the lipid residue is described.	benzophenone	114-116	NRAS proto-oncogene, GTPase	Homo sapiens	52-57
12970441-6	2003	Peptides containing this sequence that carry biotin on the carboxy terminus, as well as a photoactivated cross-linking group (benzophenone), also activate the complex and covalently associate with the CDK2/cyclin A complex in a specific manner requiring UV.	benzophenone	126-138	cyclin dependent kinase 2	Homo sapiens	201-205
12970441-6	2003	Peptides containing this sequence that carry biotin on the carboxy terminus, as well as a photoactivated cross-linking group (benzophenone), also activate the complex and covalently associate with the CDK2/cyclin A complex in a specific manner requiring UV.	benzophenone	126-138	cyclin A2	Homo sapiens	206-214
12608793-3	2003	The dipoles DP1 and DP2, in which the configuration between the epoxide oxygen and the deuterium atoms is retained, are inferred for the direct photodenitrogenation reactions (singlet state), whereas for the benzophenone-sensitized photoreactions (triplet state), after ISC, the ring-opened dipole DP3 is implied as the intermediate that is trapped by the alcohol.	benzophenone	208-220	prostaglandin D2 receptor	Homo sapiens	12-15
12608793-3	2003	The dipoles DP1 and DP2, in which the configuration between the epoxide oxygen and the deuterium atoms is retained, are inferred for the direct photodenitrogenation reactions (singlet state), whereas for the benzophenone-sensitized photoreactions (triplet state), after ISC, the ring-opened dipole DP3 is implied as the intermediate that is trapped by the alcohol.	benzophenone	208-220	transcription factor Dp-2	Homo sapiens	20-23
12608793-3	2003	The dipoles DP1 and DP2, in which the configuration between the epoxide oxygen and the deuterium atoms is retained, are inferred for the direct photodenitrogenation reactions (singlet state), whereas for the benzophenone-sensitized photoreactions (triplet state), after ISC, the ring-opened dipole DP3 is implied as the intermediate that is trapped by the alcohol.	benzophenone	208-220	APC regulator of WNT signaling pathway	Homo sapiens	298-301
12872270-1	2003	In a previous study utilizing benzophenone-based topological probes to study conformationally dependent changes in mouse muscle nicotinic acetylcholine receptor (nAChR) topology, electrospray ionization tandem mass spectrometric (ESI-MS/MS) analysis led to a consistent -2.0 Da mass deviation from expected values.	benzophenone	30-42	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	162-167
12181451-2	2002	We recently described the preparation of a photoactivatable derivative of MIP-1alpha labeled with a benzophenone group at the extreme N-terminal end, which is a determinant for the agonist character of chemokines.	benzophenone	100-112	C-C motif chemokine receptor 1	Homo sapiens	74-84
12503623-11	2002	This principle is established and explored with benzophenone-containing analogues of angiotensin II and the two known human angiotensin II receptors AT1 and AT2, determining contact points in both receptors.	benzophenone	48-60	angiotensinogen	Homo sapiens	85-99
12665309-2	2002	In non-polar cyclohexane, 4-MBP triplet has an (n,pi*) configuration with the typical triplet-triplet absorption spectrum of benzophenone (lambda(max) ca.	benzophenone	125-137	myelin basic protein	Homo sapiens	28-31
12160905-4	2002	On the other hand, with the addition of Escherichia coli membranes expressing recombinant human P450 2A6 and NADPH-cytochrome P450 reductase (NPR), benzophenone showed umu gene expression (64 umu units/min/nmol) P450 2A6).	benzophenone	148-160	cytochrome p450 oxidoreductase	Homo sapiens	109-140
12160905-4	2002	On the other hand, with the addition of Escherichia coli membranes expressing recombinant human P450 2A6 and NADPH-cytochrome P450 reductase (NPR), benzophenone showed umu gene expression (64 umu units/min/nmol) P450 2A6).	benzophenone	148-160	cytochrome p450 oxidoreductase	Homo sapiens	142-145
12160905-5	2002	Moderate activation of benzophenone by P450 1A1/NPR membranes, 1A2/NPR membranes, or 1B1/NPR membranes was also observed.	benzophenone	23-35	cytochrome p450 oxidoreductase	Homo sapiens	48-51
12160905-5	2002	Moderate activation of benzophenone by P450 1A1/NPR membranes, 1A2/NPR membranes, or 1B1/NPR membranes was also observed.	benzophenone	23-35	cytochrome p450 oxidoreductase	Homo sapiens	67-70
12160905-5	2002	Moderate activation of benzophenone by P450 1A1/NPR membranes, 1A2/NPR membranes, or 1B1/NPR membranes was also observed.	benzophenone	23-35	olfactory receptor family 1 subfamily B member 1	Homo sapiens	82-88
12160905-5	2002	Moderate activation of benzophenone by P450 1A1/NPR membranes, 1A2/NPR membranes, or 1B1/NPR membranes was also observed.	benzophenone	23-35	cytochrome p450 oxidoreductase	Homo sapiens	67-70
12127511-1	2002	We investigated whether the benzophenone moiety can be used as core element of steroid sulfatase (STS) inhibitors.	benzophenone	28-40	steroid sulfatase	Homo sapiens	79-96
12503623-11	2002	This principle is established and explored with benzophenone-containing analogues of angiotensin II and the two known human angiotensin II receptors AT1 and AT2, determining contact points in both receptors.	benzophenone	48-60	angiotensinogen	Homo sapiens	124-138
12503623-11	2002	This principle is established and explored with benzophenone-containing analogues of angiotensin II and the two known human angiotensin II receptors AT1 and AT2, determining contact points in both receptors.	benzophenone	48-60	angiotensin II receptor type 1	Homo sapiens	149-152
12503623-11	2002	This principle is established and explored with benzophenone-containing analogues of angiotensin II and the two known human angiotensin II receptors AT1 and AT2, determining contact points in both receptors.	benzophenone	48-60	angiotensin II receptor type 2	Homo sapiens	157-160
11354909-1	2001	The estrogenic activity of benzophenone and its metabolites, benzhydrol and p-hydroxybenzophenone, were investigated in vitro by estrogen receptor (ER) competitive ligand binding assay and in vivo by uterotrophic assay in juvenile female Sprague-Dawley (SD) rats.	benzophenone	27-39	estrogen receptor 1	Rattus norvegicus	129-146
11549461-1	2001	We report the initial structure-activity relationship study (SAR) (in particular logP) of a series of compounds based upon 4-sulfamated phenyl ketones as potent inhibitors of the enzyme estrone sulfatase (ES).	benzophenone	136-150	steroid sulfatase	Homo sapiens	186-203
11352748-5	2001	A fluorophosphonate inhibitor of FAAH containing a photoactivatable benzophenone group was synthesized and used to locate a region of the enzyme implicated in substrate binding.	benzophenone	68-80	fatty acid amide hydrolase	Homo sapiens	33-37
11354909-1	2001	The estrogenic activity of benzophenone and its metabolites, benzhydrol and p-hydroxybenzophenone, were investigated in vitro by estrogen receptor (ER) competitive ligand binding assay and in vivo by uterotrophic assay in juvenile female Sprague-Dawley (SD) rats.	benzophenone	27-39	estrogen receptor 1	Rattus norvegicus	148-150
10603306-7	1999	The principle tool used in the identification process was a benzophenone-based glycosylation site peptide that was shown to be crosslinked to Ost1p.	benzophenone	60-72	dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1	Saccharomyces cerevisiae S288C	142-147
11268774-0	2001	Benzophenone derivatives and related compounds as potent histamine H3-receptor antagonists and potential PET/SPECT ligands.	benzophenone	0-12	histamine receptor H3	Mus musculus	57-78
11055337-0	2000	Synthesis and preliminary analysis of a P-glycoprotein-specific [3H]-benzophenone photoaffinity label based on (-)-stipiamide.	benzophenone	69-81	ATP binding cassette subfamily B member 1	Homo sapiens	40-54
10889020-4	2000	The photoreactive PTH(1-34) analogue K27 contains a benzophenone (BP) moiety on Lys(27).	benzophenone	52-64	parathyroid hormone	Homo sapiens	18-21
10889020-4	2000	The photoreactive PTH(1-34) analogue K27 contains a benzophenone (BP) moiety on Lys(27).	benzophenone	66-68	parathyroid hormone	Homo sapiens	18-21
10893310-4	2000	This benzophenone derivative of combretastatin A-4 showed remarkable antineoplastic activity, and the benzophenone derivative of combretastatin A-1 was therefore synthesized.	benzophenone	5-17	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	47-50
10893310-4	2000	This benzophenone derivative of combretastatin A-4 showed remarkable antineoplastic activity, and the benzophenone derivative of combretastatin A-1 was therefore synthesized.	benzophenone	102-114	BCL2 related protein A1	Homo sapiens	144-147
11803700-0	2000	NTP technical report on the toxicity studies of benzophenone (CAS No.	benzophenone	48-60	breast cancer anti-estrogen resistance 1	Mus musculus	62-65
10727100-0	2000	Design and evaluation of benzophenone-containing conformationally constrained ligands as tools for photoaffinity scanning of the integrin alphaVbeta3-ligand bimolecular interaction.	benzophenone	25-37	integrin subunit alpha V	Homo sapiens	129-149
11170411-1	2001	Gelsolin, an actin and phosphoinositide binding protein, was photoaffinity labeled using a variety of benzophenone-containing phosphoinositide polyphosphate analogues.	benzophenone	102-114	gelsolin	Homo sapiens	0-8
11041870-1	2000	To develop molecules capable of directly probing the catechol binding region of the beta(2)-adrenergic receptor (beta(2)AR), novel benzophenone- and fluorenone-based beta(2)AR antagonists were prepared as potential photoaffinity probes.	benzophenone	131-143	adrenoceptor beta 2	Homo sapiens	113-122
10677290-0	2000	Photocrosslinking of benzophenone-labeled single cysteine troponin I mutants to other thin filament proteins.	benzophenone	21-33	troponin I, fast skeletal muscle	Oryctolagus cuniculus	58-68
10461746-3	1999	To this end, we have developed photoreactive benzophenone (BP)-containing PTH analogs which can be specifically and efficiently cross-linked to the human (h) PTH/PTHrP receptor.	benzophenone	45-57	parathyroid hormone	Homo sapiens	74-77
10461746-3	1999	To this end, we have developed photoreactive benzophenone (BP)-containing PTH analogs which can be specifically and efficiently cross-linked to the human (h) PTH/PTHrP receptor.	benzophenone	45-57	parathyroid hormone 1 receptor	Homo sapiens	158-176
10461746-6	1999	The photo-induced cross-linking of the radioiodinated antagonist (125I-ANT) to the recombinant hPTH/PTHrP receptor followed by SDS-PAGE analysis reveals a single radiolabeled band of approximately 85kDa, similar to that observed after cross-linking of a radioiodinated BP-containing agonist.	benzophenone	269-271	solute carrier family 25 member 6	Homo sapiens	71-74
10461746-3	1999	To this end, we have developed photoreactive benzophenone (BP)-containing PTH analogs which can be specifically and efficiently cross-linked to the human (h) PTH/PTHrP receptor.	benzophenone	59-61	parathyroid hormone	Homo sapiens	74-77
10461746-3	1999	To this end, we have developed photoreactive benzophenone (BP)-containing PTH analogs which can be specifically and efficiently cross-linked to the human (h) PTH/PTHrP receptor.	benzophenone	59-61	parathyroid hormone 1 receptor	Homo sapiens	158-176
10461746-4	1999	In this report, we describe the photocross-linking of a BP-containing PTH antagonist, [Nle8,18,D-2-Nal12,Lys13(epsilon-BP),2-Nal23,Tyr34]bPT H(7-34)NH2 (ANT) to the recombinant hPTH/PTHrP receptor stably expressed in human embryonic kidney cells (HEK-293, clone C-21).	benzophenone	56-58	parathyroid hormone	Homo sapiens	70-73
10461746-4	1999	In this report, we describe the photocross-linking of a BP-containing PTH antagonist, [Nle8,18,D-2-Nal12,Lys13(epsilon-BP),2-Nal23,Tyr34]bPT H(7-34)NH2 (ANT) to the recombinant hPTH/PTHrP receptor stably expressed in human embryonic kidney cells (HEK-293, clone C-21).	benzophenone	56-58	solute carrier family 25 member 6	Homo sapiens	153-156
10461746-4	1999	In this report, we describe the photocross-linking of a BP-containing PTH antagonist, [Nle8,18,D-2-Nal12,Lys13(epsilon-BP),2-Nal23,Tyr34]bPT H(7-34)NH2 (ANT) to the recombinant hPTH/PTHrP receptor stably expressed in human embryonic kidney cells (HEK-293, clone C-21).	benzophenone	56-58	parathyroid hormone	Homo sapiens	177-181
10461746-4	1999	In this report, we describe the photocross-linking of a BP-containing PTH antagonist, [Nle8,18,D-2-Nal12,Lys13(epsilon-BP),2-Nal23,Tyr34]bPT H(7-34)NH2 (ANT) to the recombinant hPTH/PTHrP receptor stably expressed in human embryonic kidney cells (HEK-293, clone C-21).	benzophenone	56-58	parathyroid hormone like hormone	Homo sapiens	182-187
10461746-6	1999	The photo-induced cross-linking of the radioiodinated antagonist (125I-ANT) to the recombinant hPTH/PTHrP receptor followed by SDS-PAGE analysis reveals a single radiolabeled band of approximately 85kDa, similar to that observed after cross-linking of a radioiodinated BP-containing agonist.	benzophenone	269-271	parathyroid hormone 1 receptor	Homo sapiens	95-114
29711747-1	1999	Information on the reaction path for the 1,2-eliminiation of LiNMe2 to form benzophenone is provided by the X-ray crystal structure analysis of the tetrahedral adduct [(Ph)2 (NMe2 )C(OLi) THF]2 (a portion of the structure is shown schematically), which is prepared from N,N-dimethylbenzamide and phenyllithium.	benzophenone	76-88	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	63-67
9817594-3	1998	Specifically, we have studied the region of the receptor that interacts with the midregion of PTH-(1-34), position 13, using a benzophenone-containing photoaffinity ligand, 125I-[Nle(8,18),Lys13(epsilon-pBz2),L-2-NaI23,Arg(26,2 7),Tyr34]bPTH-(1-34)NH2 (125I-K13).	benzophenone	127-139	parathyroid hormone	Homo sapiens	94-97
9928000-2	1998	For this purpose, a series of photoreactive analogues of PACAP(1-27) containing a photoreactive benzophenone (BP) residue in different peptide structural domains were utilized to analyze the interaction of PACAP(1-27) with pig PACAP type 1 receptors.	benzophenone	96-108	adenylate cyclase activating polypeptide 1	Sus scrofa	57-62
9928000-2	1998	For this purpose, a series of photoreactive analogues of PACAP(1-27) containing a photoreactive benzophenone (BP) residue in different peptide structural domains were utilized to analyze the interaction of PACAP(1-27) with pig PACAP type 1 receptors.	benzophenone	110-112	adenylate cyclase activating polypeptide 1	Sus scrofa	57-62
9839012-0	1998	The design, synthesis, and initial evaluation of benzophenone-containing peptides as potential photoaffinity labels of oligosaccharyltransferase.	benzophenone	49-61	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	119-144
9839012-1	1998	The benzophenone photophore was incorporated into protected tripeptides and tetrapeptides as photoactivatable probes to study the multimeric enzyme oligosaccharyltransferase (OST).	benzophenone	4-16	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	148-173
9839012-1	1998	The benzophenone photophore was incorporated into protected tripeptides and tetrapeptides as photoactivatable probes to study the multimeric enzyme oligosaccharyltransferase (OST).	benzophenone	4-16	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	175-178
7654710-2	1995	Design, synthesis and characterization of photoreactive benzophenone-containing analogs of parathyroid hormone.	benzophenone	56-68	parathyroid hormone	Homo sapiens	91-110
9353409-0	1997	Design, synthesis and utility of novel benzophenone-containing calcitonin analogs for photoaffinity labeling the calcitonin receptor.	benzophenone	39-51	calcitonin related polypeptide alpha	Homo sapiens	63-73
9353409-0	1997	Design, synthesis and utility of novel benzophenone-containing calcitonin analogs for photoaffinity labeling the calcitonin receptor.	benzophenone	39-51	calcitonin receptor	Homo sapiens	113-132
9353409-2	1997	In this study, we report the design, synthesis and characterization of four potent bioactive and photoreactive CT analogs, each of which contains a single benzophenone moiety inserted at different and discrete locations within the CT molecule.	benzophenone	155-167	calcitonin related polypeptide alpha	Homo sapiens	111-113
9353409-2	1997	In this study, we report the design, synthesis and characterization of four potent bioactive and photoreactive CT analogs, each of which contains a single benzophenone moiety inserted at different and discrete locations within the CT molecule.	benzophenone	155-167	calcitonin related polypeptide alpha	Homo sapiens	231-233
9353409-11	1997	These benzophenone-containing CT analogs should facilitate studies of hormone-receptor interactions and allow the direct identification of a CT binding domain(s) within the receptor by the analysis of photochemically cross-linked conjugates.	benzophenone	6-18	calcitonin related polypeptide alpha	Homo sapiens	30-32
9353409-11	1997	These benzophenone-containing CT analogs should facilitate studies of hormone-receptor interactions and allow the direct identification of a CT binding domain(s) within the receptor by the analysis of photochemically cross-linked conjugates.	benzophenone	6-18	nuclear receptor subfamily 4 group A member 1	Homo sapiens	70-86
8961954-9	1996	In addition, the highly potent benzophenone (pBz2)-containing PTH-derived radioligand [Nle8,18,Lys13(epsilon-pBz2),L-2-Nal23,Tyr34 3-125I)]bPTH(1-34)NH2 can photoaffinity cross-link specifically to the nonglycosylated receptor.	benzophenone	31-43	parathyroid hormone	Homo sapiens	62-65
8974455-2	1995	These photoaffinity reagents would possess a photoactive 3-azidophenothiazine group for cross-linking the hydrophobic binding domain of CaM, a second photoactive benzophenone group that would be activated at a different wavelength than the 3-azidophenothiazine group, and a suitable radiolabel.	benzophenone	162-174	calmodulin 3	Homo sapiens	136-139
8974455-5	1995	The phenothiazines that possessed photoactive 3-azido and benzophenone groups and in which one of the piperazine nitrogens in the side chain was converted to a quaternary, N-methylammonium iodide inhibited the calmodulin-mediated activation of phosphodiesterase at a level comparable to that of chlorpromazine.	benzophenone	58-70	calmodulin 3	Homo sapiens	210-220
8789250-2	1995	Reaction with benzophenone triplet occurs with a near-diffusion-controlled rate constant of 7.6 x 10(9) M-1s-1 in acetonitrile and probably involves charge transfer.	benzophenone	14-26	tumor associated calcium signal transducer 2	Homo sapiens	104-110
7654710-5	1995	Our approach to studying the nature of the bimolecular interface between hormone and receptor is to use a series of specially designed photoreactive benzophenone- (BP-) containing PTH analogs in "photoaffinity scanning" of the PTH/PTHrP receptor.	benzophenone	149-161	parathyroid hormone	Homo sapiens	180-183
7654710-5	1995	Our approach to studying the nature of the bimolecular interface between hormone and receptor is to use a series of specially designed photoreactive benzophenone- (BP-) containing PTH analogs in "photoaffinity scanning" of the PTH/PTHrP receptor.	benzophenone	149-161	parathyroid hormone 1 receptor	Homo sapiens	227-245
7654711-4	1995	In this report we describe the cloning, characterization, and biological activity of the cloned human (h) PTH/PTHrP receptor (Rc) and cross-linking of a benzophenone-substituted PTH analog, [Nle8,18,Lys13(epsilon-pBZ2),L-2-Nal23,Tyr34]bPTH(1-34 )NH2(K13), to cells endogenously expressing the Rc and cells transiently or stably transfected with the human Rc.	benzophenone	153-165	parathyroid hormone 1 receptor	Homo sapiens	106-124
7654711-4	1995	In this report we describe the cloning, characterization, and biological activity of the cloned human (h) PTH/PTHrP receptor (Rc) and cross-linking of a benzophenone-substituted PTH analog, [Nle8,18,Lys13(epsilon-pBZ2),L-2-Nal23,Tyr34]bPTH(1-34 )NH2(K13), to cells endogenously expressing the Rc and cells transiently or stably transfected with the human Rc.	benzophenone	153-165	parathyroid hormone	Homo sapiens	106-109
2373153-2	1990	Electrophoretic analysis of lens membrane proteins photoaffinity-labeled with benzophenone[125I]calmodulin confirmed our previous observation [Louis, Johnson and Turnquist (1985) Eur.	benzophenone	78-90	calmodulin	Bos taurus	96-106
8313384-2	1994	CAI, a carboxyamido-triazole with a halogenated benzophenone tail, is a novel inhibitor of receptor-operated calcium influx and arachidonic acid release which inhibits malignant proliferation, invasion, and metastasis.	benzophenone	48-60	carbonic anhydrase 1	Homo sapiens	0-3
8313384-4	1994	Four families of molecular modifications of the CAI parent were synthesized: (I) modification or substitution of the triazole ring; (II) removal of the substituted benzophenone tail; (III) dehalogenation or partial truncation of the benzophenone moiety; and (IV) removal of the triazole and altered substitutions of the benzophenone tail.	benzophenone	164-176	carbonic anhydrase 1	Homo sapiens	48-51
8313384-4	1994	Four families of molecular modifications of the CAI parent were synthesized: (I) modification or substitution of the triazole ring; (II) removal of the substituted benzophenone tail; (III) dehalogenation or partial truncation of the benzophenone moiety; and (IV) removal of the triazole and altered substitutions of the benzophenone tail.	benzophenone	233-245	carbonic anhydrase 1	Homo sapiens	48-51
8313384-4	1994	Four families of molecular modifications of the CAI parent were synthesized: (I) modification or substitution of the triazole ring; (II) removal of the substituted benzophenone tail; (III) dehalogenation or partial truncation of the benzophenone moiety; and (IV) removal of the triazole and altered substitutions of the benzophenone tail.	benzophenone	233-245	carbonic anhydrase 1	Homo sapiens	48-51
2386781-0	1990	Phenyl azide substituted and benzophenone-substituted phosphonamides of 7-methylguanosine 5"-triphosphate as photoaffinity probes for protein synthesis initiation factor eIF-4E and a proteolytic fragment containing the cap-binding site.	benzophenone	29-41	eukaryotic translation initiation factor 4E	Homo sapiens	170-176
34771031-0	2021	An Investigation into the Interaction between Double Hydroxide-Based Antioxidant Benzophenone Derivatives and Cyclooxygenase 2.	benzophenone	81-93	prostaglandin-endoperoxide synthase 2	Homo sapiens	110-126
34914995-4	2022	BP-3 was the most abundant benzophenone analog in sludge (range: 0.581-305 ng/g dw), whereas no difference was found for BP-3 in sludge from different regions (p > 0.05).	benzophenone	27-39	BP3	Homo sapiens	0-4
34583069-7	2022	Weighted detection frequencies were 63.6% for bisphenol-A (BPA), 27.9-63.4% for PBs, and 39.5% for benzophenone-3 (BP-3).	benzophenone	99-111	BP3	Homo sapiens	115-119
34826089-12	2022	This study demonstrated that benzophenone derivatives especially BP-3 can affect the duration of pregnancy and consequently fetal growth in the early and late stages of pregnancy.	benzophenone	29-41	BP3	Homo sapiens	65-69
34632942-0	2021	In silico identification of novel benzophenone-coumarin derivatives as SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitors.	benzophenone	34-46	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	112-116
34632942-1	2021	In this study, we propose our novel benzophenone-coumarin derivatives (BCDs) as potent inhibitors of the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 virus, one of the key targets that are involved in the viral genome replication.	benzophenone	36-48	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	135-139
35337918-6	2022	These transactivation experiments revealed hexylparaben, benzylparaben and benzophenone-10 as RORgamma agonists (EC50 values: 144 +- 97nM, 3.39 +- 1.74microM and 1.67 +- 1.04microM, respectively), and they could restore RORgamma activity after suppression by an inverse agonist.	benzophenone	75-87	RAR-related orphan receptor gamma	Mus musculus	94-102
34408404-12	2021	Depsidone showed the highest binding affinity for HER-2 (-9.2 kcal.mol-1) and benzophenone for ER-alpha (-8.0 kcal.mol-1).	benzophenone	78-90	estrogen receptor 1	Homo sapiens	95-103
34408404-13	2021	Conclusion: Benzophenone displays potency as an anticancer agent through blocking ER-alpha.	benzophenone	12-24	estrogen receptor 1	Homo sapiens	82-90
34257390-7	2021	Concentrations of 2,5-dichlorophenol were the most strongly correlated between pair-members (tau = 0.46), followed by benzophenone-3 (tau = 0.31) and bisphenol A (tau = 0.21).	benzophenone	118-130	microtubule associated protein tau	Homo sapiens	134-137
35395008-0	2022	Discovery of novel benzophenone integrated derivatives as anti-Alzheimer"s agents targeting presenilin-1 and presenilin-2 inhibition: A computational approach.	benzophenone	19-31	presenilin 1	Homo sapiens	92-104
35395008-0	2022	Discovery of novel benzophenone integrated derivatives as anti-Alzheimer"s agents targeting presenilin-1 and presenilin-2 inhibition: A computational approach.	benzophenone	19-31	presenilin 2	Homo sapiens	109-121
35337918-6	2022	These transactivation experiments revealed hexylparaben, benzylparaben and benzophenone-10 as RORgamma agonists (EC50 values: 144 +- 97nM, 3.39 +- 1.74microM and 1.67 +- 1.04microM, respectively), and they could restore RORgamma activity after suppression by an inverse agonist.	benzophenone	75-87	RAR-related orphan receptor gamma	Mus musculus	220-228
6251919-1	1980	It has been shown that during fast (< 1 ms) photosensitized by anthraquinone or benzophenone reduction of cytochrome c in 0.15 N NaOH water-glycerol solutions ferrocytochrome c in a nonequilibrium state with increased reactivity was formed.	benzophenone	83-95	cytochrome c, somatic	Homo sapiens	109-121
2755990-0	1989	Photointeraction of benzophenone triplet with lysozyme.	benzophenone	20-32	lysozyme	Homo sapiens	46-54
2755990-1	1989	The quenching of the benzophenone triplet by lysozyme and its constituent amino acids in aqueous solutions have been studied.	benzophenone	21-33	lysozyme	Homo sapiens	45-53
2755990-2	1989	Native lysozyme quenches the benzophenone triplet with a high rate constant, 4 x 10(9) M-1 s-1.	benzophenone	29-41	lysozyme	Homo sapiens	7-15
2755990-6	1989	Reduced and carboxymethylated lysozyme shows a higher quenching rate (7.8 x 10(9) M-1 s-1) and a larger benzophenone consumption yield (0.07).	benzophenone	104-116	lysozyme	Homo sapiens	30-38
3772715-5	1986	The NaBH4 reduction of the ketone of the benzophenone moiety of the conjugates and subsequent treatment with beta-glucuronidase allowed identification of the reduced aglycones with authentic samples using gas chromatography-mass spectrometry.	benzophenone	41-53	glucuronidase, beta	Rattus norvegicus	109-127
18964028-4	1986	With PABP, the low lying triplet state in polar solvents is (3)(CT) and in non-polar solvents is (3)(n, pi(*)); PABP on filter paper results in spectral characteristics similar to those of PABP in polar solvents at 77 K. The lifetime of PABP is longer than that of BP, indicating a (3)(CT) low-lying triplet state.	benzophenone	7-9	poly(A) binding protein cytoplasmic 1	Homo sapiens	112-116
18964028-4	1986	With PABP, the low lying triplet state in polar solvents is (3)(CT) and in non-polar solvents is (3)(n, pi(*)); PABP on filter paper results in spectral characteristics similar to those of PABP in polar solvents at 77 K. The lifetime of PABP is longer than that of BP, indicating a (3)(CT) low-lying triplet state.	benzophenone	7-9	poly(A) binding protein cytoplasmic 1	Homo sapiens	112-116
18964028-4	1986	With PABP, the low lying triplet state in polar solvents is (3)(CT) and in non-polar solvents is (3)(n, pi(*)); PABP on filter paper results in spectral characteristics similar to those of PABP in polar solvents at 77 K. The lifetime of PABP is longer than that of BP, indicating a (3)(CT) low-lying triplet state.	benzophenone	7-9	poly(A) binding protein cytoplasmic 1	Homo sapiens	112-116
6238030-2	1984	3"-O-(4-Benzoyl)benzoyl-ATP (Bz2ATP), an analog of ATP containing a photoreactive benzophenone moiety, was used as a probe of the ATP binding site of myosin subfragment 1 (SF1).	benzophenone	82-94	myosin heavy chain 14	Homo sapiens	150-156
6827835-2	1983	A few substituted diphenyl ketones were observed to inhibit uteroglobin-progesterone binding in a dose-dependent manner.	benzophenone	18-34	secretoglobin family 1A member 1	Homo sapiens	60-71
3920681-0	1985	Inhibitory effects of tannic acid and benzophenone on soybean lipoxygenase and ram seminal vesicle cyclooxygenase.	benzophenone	38-50	linoleate 9S-lipoxygenase-4	Glycine max	62-74
33540164-1	2021	2,4-Dihydroxybenzophenone (BP-1), a typically known derivative of the benzophenone-type UV filter, has been frequently detected in aqueous environments and poses a potential risk to human health and the entire ecosystem.	benzophenone	13-25	BP1	Homo sapiens	27-31
1265140-1	1976	Benzophenone-containing bovine serum albumin.	benzophenone	0-12	albumin	Homo sapiens	31-44
33769204-3	2021	In the present study, we identified benzophenone thio- and semicarbazone scaffolds as novel DPP-IV inhibitors.	benzophenone	36-48	dipeptidyl peptidase 4	Homo sapiens	92-98
34056636-5	2021	In the presence of various H-donor partners, the UV-irradiation of the photoreactive ABPP probes generates different adducts, the expected "benzophenone-like" adducts (pathway 1) in addition to "benzoxanthone" adducts (via two other pathways, 2 and 3).	benzophenone	140-152	amyloid beta precursor protein	Homo sapiens	85-89
34056636-9	2021	This work provides a proof-of-principle that (pro-)ABPP probes can generate benzophenone-like metabolites enabling optimized activity-based protein profiling conditions that will be instrumental to analyze the interactome of early lead antiplasmodial 3-benzylmenadiones displaying an original and innovative mode of action.	benzophenone	76-88	amyloid beta precursor protein	Homo sapiens	51-55
33464888-7	2021	The benzophenone moiety rearranged a CRY1 region called the "lid loop" located outside of the compound-binding pocket and formed a unique interaction with Phe409 in the lid loop.	benzophenone	4-16	cryptochrome circadian regulator 1	Homo sapiens	37-41
33576094-6	2021	The UV absorbers, benzophenone and PABA, showed opposite gender distribution of PACD.	benzophenone	18-30	PACD	Homo sapiens	80-84
32407875-0	2020	Benzophenone-3 and benzophenone-8 exhibit obesogenic activity via peroxisome proliferator-activated receptor gamma pathway.	benzophenone	19-31	peroxisome proliferator activated receptor gamma	Homo sapiens	66-114
32959447-0	2020	Novel Photoinitiators Based on Benzophenone-Triphenylamine Hybrid Structure for LED Photopolymerization.	benzophenone	31-43	small integral membrane protein 10 like 2A	Homo sapiens	80-83
32959447-4	2020	Remarkably, TBP-TPA owning trifunctional benzophenone group exhibits a better Type II PI behavior than well-known 2-isopropylthioxanthone for photopolymerization under LED@365 and 405 nm irradiation.	benzophenone	41-53	small integral membrane protein 10 like 2A	Homo sapiens	168-171
33084682-0	2020	The influence of spin-orbit coupling, Duschinsky rotation and displacement vector on the rate of intersystem crossing of benzophenone and its fused analog fluorenone: a time dependent correlation function based approach.	benzophenone	121-133	spindlin 1	Homo sapiens	17-21
33084682-6	2020	Interestingly, our analyses reveal that the combined effect of spin-orbit coupling and the number of normal modes could increase the rate of ISC of benzophenone by three orders in comparison to that of fluorenone.	benzophenone	148-160	spindlin 1	Homo sapiens	63-67
32726716-0	2020	In vitro and in vivo screening for environmentally friendly benzophenone-type UV filters with beneficial tyrosinase inhibition activity.	benzophenone	60-72	tyrosinase	Oryzias latipes	105-115
32946892-0	2020	Bisphenol A and benzophenone-3 exposure alters milk protein expression and its transcriptional regulation during functional differentiation of the mammary gland in vitro.	benzophenone	16-28	casein alpha s2-like A	Mus musculus	47-59
31493708-6	2019	Among the series, compound 8i with electron withdrawing fluoro group at the para position of the benzoyl ring of benzophenone was characterized by highest IC50 values for both COX-1 and COX-2 inhibition, which is comparable to the standard drug.	benzophenone	113-125	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	176-181
32525197-2	2020	Here, we designed a novel tri-functional platform and facilely constructed dual-functional surfaces in one pot by combining the "sulfur(vi)-fluoride exchange" (SuFEx) click reaction, photoinitiated polymerization and benzophenone photochemistry.	benzophenone	217-229	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	26-29
31939680-0	2020	Effects of Benzophenone-3 and Propylparaben on Estrogen Receptor-Dependent R-Loops and DNA Damage in Breast Epithelial Cells and Mice.	benzophenone	11-24	estrogen receptor 1 (alpha)	Mus musculus	47-64
31829592-0	2019	Benzophenone Compounds, from a Marine-Derived Strain of the Fungus Pestalotiopsis neglecta, Inhibit Proliferation of Pancreatic Cancer Cells by Targeting the MEK/ERK Pathway.	benzophenone	0-12	mitogen-activated protein kinase kinase 7	Homo sapiens	158-161
31829592-0	2019	Benzophenone Compounds, from a Marine-Derived Strain of the Fungus Pestalotiopsis neglecta, Inhibit Proliferation of Pancreatic Cancer Cells by Targeting the MEK/ERK Pathway.	benzophenone	0-12	mitogen-activated protein kinase 1	Homo sapiens	162-165
31829592-8	2019	Mechanistically, benzophenone derivatives not only inhibit MEK activity in the cytoplasm but also suppress ERK activity in the cytoplasm and nucleus.	benzophenone	17-29	mitogen-activated protein kinase kinase 7	Homo sapiens	59-62
31829592-8	2019	Mechanistically, benzophenone derivatives not only inhibit MEK activity in the cytoplasm but also suppress ERK activity in the cytoplasm and nucleus.	benzophenone	17-29	mitogen-activated protein kinase 1	Homo sapiens	107-110
31829592-9	2019	An in silico study suggests that benzophenone derivatives could potentially inhibit MEK activity by binding to the allosteric pocket in MEK.	benzophenone	33-45	mitogen-activated protein kinase kinase 7	Homo sapiens	84-87
31829592-9	2019	An in silico study suggests that benzophenone derivatives could potentially inhibit MEK activity by binding to the allosteric pocket in MEK.	benzophenone	33-45	mitogen-activated protein kinase kinase 7	Homo sapiens	136-139
31493708-6	2019	Among the series, compound 8i with electron withdrawing fluoro group at the para position of the benzoyl ring of benzophenone was characterized by highest IC50 values for both COX-1 and COX-2 inhibition, which is comparable to the standard drug.	benzophenone	113-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
31362197-6	2019	Interestingly, benzophenone derivative 18 showed the highest affinity among all tested compounds (hH3R Ki = 3.12 nM).	benzophenone	15-27	histamine receptor H3	Homo sapiens	98-102
31378415-0	2019	Corrigendum to "Role of type I and type II radicals in DNA damage and activation of Caspase 3 via mitochondrial pathway induced by photosensitized benzophenone" [Toxicol.	benzophenone	147-159	caspase 3	Homo sapiens	84-93
30685680-1	2019	2,4-Dihydroxybenzophenone (BP-1) is an important component and metabolite of benzophenone-type (BPs) UV filters, it is widely used in commercial products and frequently detected in environmental media and organism samples.	benzophenone	13-25	BP1	Homo sapiens	27-31
31082641-1	2019	Benzophenone derivatives, including benzophenone-1 (C13H10O3, BP1), benzophenone-3 (C14H12O3, BP3) and benzophenone-8 (C14H12O4, BP8), that used as UV filters are currently viewed as emerging contaminants.	benzophenone	0-12	BP1	Homo sapiens	62-65
31082641-1	2019	Benzophenone derivatives, including benzophenone-1 (C13H10O3, BP1), benzophenone-3 (C14H12O3, BP3) and benzophenone-8 (C14H12O4, BP8), that used as UV filters are currently viewed as emerging contaminants.	benzophenone	0-12	BP3	Homo sapiens	94-97
31082641-1	2019	Benzophenone derivatives, including benzophenone-1 (C13H10O3, BP1), benzophenone-3 (C14H12O3, BP3) and benzophenone-8 (C14H12O4, BP8), that used as UV filters are currently viewed as emerging contaminants.	benzophenone	0-12	BP8	Homo sapiens	129-132
31364504-3	2019	Benzophenone (BP) and its derivatives, namely, benzophenone 1 (BP1), is commonly used in sunscreens as a UV blocker.	benzophenone	0-12	BP1	Homo sapiens	63-66
31364504-3	2019	Benzophenone (BP) and its derivatives, namely, benzophenone 1 (BP1), is commonly used in sunscreens as a UV blocker.	benzophenone	14-16	BP1	Homo sapiens	63-66
32110301-6	2019	Then, using the present method, the scale-up of the reactions was achieved at an isolated rate of 19 mg min-1 for the product of the Claisen-Schmidt condensation, 21 mg min-1 for the synthesis of benzophenone oxime from benzophenone, 31 mg min-1 for the synthesis of 4-methoxybenzaldehyde from 4-methoxybenzyl alcohol, and 40 mg min-1 for the enaminone product of the Eschenmoser coupling reaction.	benzophenone	196-208	CD59 molecule (CD59 blood group)	Homo sapiens	104-109
32110301-6	2019	Then, using the present method, the scale-up of the reactions was achieved at an isolated rate of 19 mg min-1 for the product of the Claisen-Schmidt condensation, 21 mg min-1 for the synthesis of benzophenone oxime from benzophenone, 31 mg min-1 for the synthesis of 4-methoxybenzaldehyde from 4-methoxybenzyl alcohol, and 40 mg min-1 for the enaminone product of the Eschenmoser coupling reaction.	benzophenone	196-208	CD59 molecule (CD59 blood group)	Homo sapiens	169-174
32110301-6	2019	Then, using the present method, the scale-up of the reactions was achieved at an isolated rate of 19 mg min-1 for the product of the Claisen-Schmidt condensation, 21 mg min-1 for the synthesis of benzophenone oxime from benzophenone, 31 mg min-1 for the synthesis of 4-methoxybenzaldehyde from 4-methoxybenzyl alcohol, and 40 mg min-1 for the enaminone product of the Eschenmoser coupling reaction.	benzophenone	196-208	CD59 molecule (CD59 blood group)	Homo sapiens	169-174
32110301-6	2019	Then, using the present method, the scale-up of the reactions was achieved at an isolated rate of 19 mg min-1 for the product of the Claisen-Schmidt condensation, 21 mg min-1 for the synthesis of benzophenone oxime from benzophenone, 31 mg min-1 for the synthesis of 4-methoxybenzaldehyde from 4-methoxybenzyl alcohol, and 40 mg min-1 for the enaminone product of the Eschenmoser coupling reaction.	benzophenone	196-208	CD59 molecule (CD59 blood group)	Homo sapiens	169-174
30077149-1	2018	The objective of this research was to explore the fundamental reactions between chlorine/chloramine and 2-hydroxyl-4-methoxyl benzophenone (BP3)/2-hydroxyl-4-methoxyl benzophenone-sulfonic acid (BP4), which were the most common reactions in benzophenone-type UV filters during drinking water treatment processes.	benzophenone	126-138	BP3	Homo sapiens	140-143
30598289-8	2019	The amount of BP and DiBP migrated from the PVC film was 83.53 mug L-1 and 31.30 mug L-1, respectively; whereas 71.62 mug L-1 of BP and 27.45 mug L-1 of DiBP migrated from the PP coffee capsules.	benzophenone	14-16	L1 cell adhesion molecule	Homo sapiens	67-70
30598289-8	2019	The amount of BP and DiBP migrated from the PVC film was 83.53 mug L-1 and 31.30 mug L-1, respectively; whereas 71.62 mug L-1 of BP and 27.45 mug L-1 of DiBP migrated from the PP coffee capsules.	benzophenone	14-16	L1 cell adhesion molecule	Homo sapiens	85-88
30598289-8	2019	The amount of BP and DiBP migrated from the PVC film was 83.53 mug L-1 and 31.30 mug L-1, respectively; whereas 71.62 mug L-1 of BP and 27.45 mug L-1 of DiBP migrated from the PP coffee capsules.	benzophenone	14-16	L1 cell adhesion molecule	Homo sapiens	85-88
30317168-6	2019	Of the compounds analysed, tris(2-butoxyethyl) phosphate, sucralose, caffeine, and benzophenone showed high abundancy with maximum concentrations in the mug L-1 range.	benzophenone	83-95	immunoglobulin kappa variable 1-16	Homo sapiens	157-160
30626051-6	2019	It turned out that the reduced amide mimics, upon irradiation with a benzophenone as photosensitizer, are oxidized and form low concentrations of peptide aldehydes, which then act as inhibitors of caspase-3.	benzophenone	69-81	caspase 3	Homo sapiens	197-206
30077149-1	2018	The objective of this research was to explore the fundamental reactions between chlorine/chloramine and 2-hydroxyl-4-methoxyl benzophenone (BP3)/2-hydroxyl-4-methoxyl benzophenone-sulfonic acid (BP4), which were the most common reactions in benzophenone-type UV filters during drinking water treatment processes.	benzophenone	126-138	BP4	Homo sapiens	195-198
30266542-3	2018	Specifically, clickable benzophenone-based (S)-citalopram photoprobe 6 (hSERT Ki = 0.16 nM) displayed 11-fold higher binding affinity at hSERT when compared to (S)-citalopram (hSERT Ki = 1.77 nM), and was subsequently shown to successfully undergo tandem photoaffinity labeling-biorthogonal conjugation using purified hSERT.	benzophenone	24-36	solute carrier family 6 member 4	Homo sapiens	72-77
30266542-3	2018	Specifically, clickable benzophenone-based (S)-citalopram photoprobe 6 (hSERT Ki = 0.16 nM) displayed 11-fold higher binding affinity at hSERT when compared to (S)-citalopram (hSERT Ki = 1.77 nM), and was subsequently shown to successfully undergo tandem photoaffinity labeling-biorthogonal conjugation using purified hSERT.	benzophenone	24-36	solute carrier family 6 member 4	Homo sapiens	137-142
30266542-3	2018	Specifically, clickable benzophenone-based (S)-citalopram photoprobe 6 (hSERT Ki = 0.16 nM) displayed 11-fold higher binding affinity at hSERT when compared to (S)-citalopram (hSERT Ki = 1.77 nM), and was subsequently shown to successfully undergo tandem photoaffinity labeling-biorthogonal conjugation using purified hSERT.	benzophenone	24-36	solute carrier family 6 member 4	Homo sapiens	137-142
30266542-3	2018	Specifically, clickable benzophenone-based (S)-citalopram photoprobe 6 (hSERT Ki = 0.16 nM) displayed 11-fold higher binding affinity at hSERT when compared to (S)-citalopram (hSERT Ki = 1.77 nM), and was subsequently shown to successfully undergo tandem photoaffinity labeling-biorthogonal conjugation using purified hSERT.	benzophenone	24-36	solute carrier family 6 member 4	Homo sapiens	137-142
29860169-5	2018	In the following reactions, both theoretical calculation and experimental results reveal that the generated BP+  recovers itself to BP by grabbing an electron from NO3- and the generated nitrate radicals (NO3 ) then decay to nitrogen oxides.	benzophenone	108-111	NBL1, DAN family BMP antagonist	Homo sapiens	164-167
30021286-4	2018	Five BP analogues (i.e., BP1, BP2, BP3, BP8, and 4HB) were frequently detected in both PCPs and urine, among which BP3 was the dominant analogue, accounting for 96.3% of the total BPs in PCPs and 53.2% in urine, respectively.	benzophenone	5-7	BP1	Homo sapiens	25-28
30021286-4	2018	Five BP analogues (i.e., BP1, BP2, BP3, BP8, and 4HB) were frequently detected in both PCPs and urine, among which BP3 was the dominant analogue, accounting for 96.3% of the total BPs in PCPs and 53.2% in urine, respectively.	benzophenone	5-7	BP2	Homo sapiens	30-33
30021286-4	2018	Five BP analogues (i.e., BP1, BP2, BP3, BP8, and 4HB) were frequently detected in both PCPs and urine, among which BP3 was the dominant analogue, accounting for 96.3% of the total BPs in PCPs and 53.2% in urine, respectively.	benzophenone	5-7	BP3	Homo sapiens	35-38
30021286-4	2018	Five BP analogues (i.e., BP1, BP2, BP3, BP8, and 4HB) were frequently detected in both PCPs and urine, among which BP3 was the dominant analogue, accounting for 96.3% of the total BPs in PCPs and 53.2% in urine, respectively.	benzophenone	5-7	BP8	Homo sapiens	40-43
30021286-4	2018	Five BP analogues (i.e., BP1, BP2, BP3, BP8, and 4HB) were frequently detected in both PCPs and urine, among which BP3 was the dominant analogue, accounting for 96.3% of the total BPs in PCPs and 53.2% in urine, respectively.	benzophenone	5-7	BP3	Homo sapiens	115-118
29860169-5	2018	In the following reactions, both theoretical calculation and experimental results reveal that the generated BP+  recovers itself to BP by grabbing an electron from NO3- and the generated nitrate radicals (NO3 ) then decay to nitrogen oxides.	benzophenone	108-111	NBL1, DAN family BMP antagonist	Homo sapiens	205-208
29860169-5	2018	In the following reactions, both theoretical calculation and experimental results reveal that the generated BP+  recovers itself to BP by grabbing an electron from NO3- and the generated nitrate radicals (NO3 ) then decay to nitrogen oxides.	benzophenone	108-110	NBL1, DAN family BMP antagonist	Homo sapiens	164-167
29860169-5	2018	In the following reactions, both theoretical calculation and experimental results reveal that the generated BP+  recovers itself to BP by grabbing an electron from NO3- and the generated nitrate radicals (NO3 ) then decay to nitrogen oxides.	benzophenone	108-110	NBL1, DAN family BMP antagonist	Homo sapiens	205-208
30200545-14	2018	The mixture test results suggested that there was antagonism in mutagenicity between BP and BP-1.	benzophenone	85-87	BP1	Homo sapiens	92-96
30085659-4	2018	Conjugates of benzophenone alpha-GCs with soluble or cell-bound CD1d proteins retained potent iNKT cell activating properties, with biologic effects that were modulated by acyl chain length and the resulting affinities of conjugates for iNKT cell antigen receptors.	benzophenone	14-26	CD1d molecule	Homo sapiens	64-68
28359989-4	2017	The concentration reached up 131ngL-1 for 5-benzoyl-4-hydroxy-2-ethoxybenzenesulfonic acid (BP-4), 30.0ngL-1 for 2-hydroxy-4-methoxybenzophenone (BP-3), and mean value of 158ngL-1 for benzophenone (BP).	benzophenone	132-144	leucine rich repeat containing 4C	Homo sapiens	103-108
29864929-0	2018	Synthesis and amelioration of inflammatory paw edema by novel benzophenone appended oxadiazole derivatives by exhibiting cyclooxygenase-2 antagonist activity.	benzophenone	62-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	121-137
29502395-3	2018	The tributaries ( CBPs: 19-231 ng L-1) were the main source of benzophenone compounds entering the basin ( CBPs: 20-81 ng L-1).	benzophenone	63-75	sushi repeat containing protein X-linked 2	Homo sapiens	18-22
29502395-3	2018	The tributaries ( CBPs: 19-231 ng L-1) were the main source of benzophenone compounds entering the basin ( CBPs: 20-81 ng L-1).	benzophenone	63-75	sushi repeat containing protein X-linked 2	Homo sapiens	107-111
28873254-2	2018	Reduction of benzophenone lead to UIV [OC Ph2 )][N(SiMe3 )2 ]3 , (1.1) which forms the dinuclear complex, [N(SiMe3 )2 ]3 UIV (OCPhPh-CPh2 O)UIV [N(SiMe3 )2 ]3 (1.2), through coupling of the ketyl radical species upon crystallization.	benzophenone	13-25	polyhomeotic homolog 2	Homo sapiens	42-45
32625332-1	2017	Benzophenone [FL-no: 07.032] has been evaluated as a flavouring substance, in FGE.69, by the EFSA Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food in 2008.	benzophenone	0-12	sulfatase modifying factor 1	Homo sapiens	78-81
32625332-2	2017	Benzophenone was evaluated also by JECFA (2011) and by IARC (2013) based on studies that were not considered in the EFSA opinion on FGE.69.	benzophenone	0-12	sulfatase modifying factor 1	Homo sapiens	132-135
29459933-10	2018	BP-1 (59%) based on composition profile analysis was the dominant BP derivative in urine samples of urban residents, whereas 4-OH-BP (36%) was the most prevalent BP in rural areas.	benzophenone	66-68	BP1	Homo sapiens	0-4
28990245-7	2018	Using MCF-7 cells, reduction in E-cadherin was observed following 24 weeks" exposure to 10-5  m BP-1 and 10-5  m homosalate, and reduction in beta-catenin was noted following 24 weeks" exposure to 10-5  m OMC.	benzophenone	96-98	cadherin 1	Homo sapiens	32-42
28359989-4	2017	The concentration reached up 131ngL-1 for 5-benzoyl-4-hydroxy-2-ethoxybenzenesulfonic acid (BP-4), 30.0ngL-1 for 2-hydroxy-4-methoxybenzophenone (BP-3), and mean value of 158ngL-1 for benzophenone (BP).	benzophenone	92-94	leucine rich repeat containing 4C	Homo sapiens	32-37
28042932-7	2017	Photo-cross-linking of the resulting modified mRNAs with the cap interacting protein eIF4E was successful with aryl azide and diazirine but not benzophenone, reflecting the affinity of the modified 5" caps.	benzophenone	144-156	eukaryotic translation initiation factor 4E	Homo sapiens	85-90
28430416-2	2017	We expand the photoactivatable chemistry toolbox here with a second reagent, sulfo-SBP (benzophenone).	benzophenone	88-100	selenium binding protein 1	Homo sapiens	83-86
27984751-0	2017	Benzophenone based fluorophore for selective detection of Sn2+ ion: Experimental and theoretical study.	benzophenone	0-12	solute carrier family 38 member 5	Homo sapiens	58-61
27984751-1	2017	Synthesis of novel benzophenone-based chemosensor is presented for the selective sensing of Sn2+ ion.	benzophenone	19-31	solute carrier family 38 member 5	Homo sapiens	92-95