PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17845040-2	2007	While the intermolecular reaction of acrylates, acrylonitriles, and vinyl sulfones with alkynes takes place in the presence of CoI2(PPh3)2/Zn, the reaction of enones and enals with alkynes requires the use of the CoI2(dppe)/Zn/ZnI2 system.	enones	159-165	caveolin 1	Homo sapiens	132-136
16220971-2	2005	In vitro efficacy studies show that the cytotoxicities of the COMCs directly correlate with the level of expression of GSTP1-1 in MCF-7(piGST) versus MCF-7wt breast tumors, indicating that the exocyclic enones are the actual cytotoxic species.	enones	203-209	glutathione S-transferase pi 1	Homo sapiens	119-126
17176111-3	2006	(2001) Soybean Lipoxygenase-Mediated Oxygenation of Monounsaturated Fatty Acids to Enones, J.	enones	83-89	linoleate 9S-lipoxygenase-4	Glycine max	15-27
16802811-3	2006	In this study, we establish the conjugate addition of thiols to enones as a reaction well-suited for the synthesis of dynamic combinatorial libraries (DCLs) directed by the active site of the enzyme glutathione S-transferase (GST).	enones	64-70	glutathione S-transferase kappa 1	Homo sapiens	199-224
16802811-3	2006	In this study, we establish the conjugate addition of thiols to enones as a reaction well-suited for the synthesis of dynamic combinatorial libraries (DCLs) directed by the active site of the enzyme glutathione S-transferase (GST).	enones	64-70	glutathione S-transferase kappa 1	Homo sapiens	226-229
16338138-0	2006	Activation of NFkappaB is inhibited by curcumin and related enones.	enones	60-66	nuclear factor kappa B subunit 1	Homo sapiens	14-22
14653739-4	2003	This mechanism is supported by the observation of multiphasic kinetics in the presence of high concentrations of hGSTP1-1 and the ability to trap kinetically competent exocyclic enones in aqueous acid using COMC-6 and COMC-7 as substrates.	enones	178-184	glutathione S-transferase pi 1	Homo sapiens	113-121
16833976-0	2005	Spin-polarized conceptual density functional theory study of the regioselectivity in the [2+2] photocycloaddition of enones to substituted alkenes.	enones	117-123	spindlin 1	Homo sapiens	0-4
12678821-11	2003	The highly stereoselective functionalization of both enones at the C-4, C-3 and C-2 positions by the set of Michael addition reactions of reactive 1-thiosugars is reviewed.	enones	53-59	complement C4A (Rodgers blood group)	Homo sapiens	67-75
14594285-1	2003	A new strategy which uses very cheap FeCl3 as an effective catalyst in the presence of Me3SiCl has been developed for the conjugate addition of enones and chalcone with unactivated weakly nucleophilic carbamates.	enones	144-150	malic enzyme 3	Homo sapiens	87-90
12678821-11	2003	The highly stereoselective functionalization of both enones at the C-4, C-3 and C-2 positions by the set of Michael addition reactions of reactive 1-thiosugars is reviewed.	enones	53-59	complement C2	Homo sapiens	80-83
34390826-4	2021	The results of TLR4 inhibition test in vitro showed that the double-ring conjugated enones had a good inhibitory activity, and the IC50 value of compound 4f was 0.56+-0.10 muM, and it was superior to the positive control methotrexate.To further study the anti-inflammatory effect and mechanism of double-ring conjugated enones by using LPS induced rat synovial cell inflammation model.	enones	84-90	toll-like receptor 4	Rattus norvegicus	15-19
12515454-2	2003	For aromatic and heteroaromatic enones, six-membered cyclic aldol products are formed in excellent yield with high levels of syn diastereoselectivity.	enones	32-38	synemin	Homo sapiens	125-128
10964362-1	2000	[reaction: see text] The catalytic oxidation of the allylic alcohols 1d-n with iodosobenzene diacetate, mediated by the [Cr(III)(salen)]X complex, affords the respective enones in excellent chemoselectivity for Cl(-) as counterion [complex A(Cl)], while for the counterions TfO(-) [complex A(TfO)] and PF(6)(-) [complex A(PF(6)())] nearly equal amounts of enone and epoxide are observed.	enones	170-176	sperm associated antigen 17	Homo sapiens	302-310
10964362-1	2000	[reaction: see text] The catalytic oxidation of the allylic alcohols 1d-n with iodosobenzene diacetate, mediated by the [Cr(III)(salen)]X complex, affords the respective enones in excellent chemoselectivity for Cl(-) as counterion [complex A(Cl)], while for the counterions TfO(-) [complex A(TfO)] and PF(6)(-) [complex A(PF(6)())] nearly equal amounts of enone and epoxide are observed.	enones	170-176	sperm associated antigen 17	Homo sapiens	320-330
34795801-3	2021	Control experiments reveal that the presence of a beta-silyl group in the enones is crucial for high reactivity under the optimized reaction conditions.	enones	74-80	amyloid beta precursor protein	Homo sapiens	48-54
11456594-0	2001	Soybean lipoxygenase-mediated oxygenation of monounsaturated fatty acids to enones.	enones	76-82	linoleate 9S-lipoxygenase-4	Glycine max	8-20
10930254-0	2000	Isotope effects and syn selectivity in the ene reaction of triazolinedione with conjugated enones: aziridinium imide or an open intermediate mechanism?	enones	91-97	synemin	Homo sapiens	20-23
34390826-4	2021	The results of TLR4 inhibition test in vitro showed that the double-ring conjugated enones had a good inhibitory activity, and the IC50 value of compound 4f was 0.56+-0.10 muM, and it was superior to the positive control methotrexate.To further study the anti-inflammatory effect and mechanism of double-ring conjugated enones by using LPS induced rat synovial cell inflammation model.	enones	320-326	toll-like receptor 4	Rattus norvegicus	15-19
33038311-4	2020	We also analyzed the chemical mechanism by which EGCG binds directly to NF-kappaB-p65, and found that it involves covalent reaction via enones within EGCG ring structures, as the oxidizer diamide, which prevents 1, 4-addition reactions, blocked adduct-forming reaction of biotinylated EGCG with NF-kappaB-p65.	enones	136-142	RELA proto-oncogene, NF-kB subunit	Homo sapiens	72-85
35171590-1	2022	The first direct general method for N-Me aziridination of electron-deficient olefins, enones, is described using N-methyl-O-tosylhydroxylamine as the aminating agent in the presence of a Cu(OTf)2 catalyst.	enones	86-92	POU class 2 homeobox 2	Homo sapiens	187-195
33038311-4	2020	We also analyzed the chemical mechanism by which EGCG binds directly to NF-kappaB-p65, and found that it involves covalent reaction via enones within EGCG ring structures, as the oxidizer diamide, which prevents 1, 4-addition reactions, blocked adduct-forming reaction of biotinylated EGCG with NF-kappaB-p65.	enones	136-142	RELA proto-oncogene, NF-kB subunit	Homo sapiens	295-308
29565132-0	2018	Synthesis of gamma-Sulfur-Substituted Ketones via Rh(II)/Sc(III) a Cocatalyzed Three-Component Reaction of Diazo Compounds with Thiophenols and Enones.	enones	144-150	Rh blood group D antigen	Homo sapiens	50-56
32450512-4	2020	These two dipeptide phosphine catalysts, P5 and P8, could deliver both enantiomers of a series of N2-alkylpyridazinones in good yields (up to 99%) with high enantioselectivities (up to 99% ee) via the catalyst-controlled enantiodivergent addition of pyridazinones to enones.	enones	267-273	solute carrier family 10 member 5	Homo sapiens	41-50
31293048-3	2019	One well-defined chiral CoII -complex is shown to be an efficient catalyst in the visible-light-induced conjugated addition of enones by alkyl and acyl radicals, providing synthetically valued chiral ketones and 1,4-dicarbonyls in 47->99 % yields with up to 97:3 e.r.	enones	127-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-28
32960201-0	2020	Photoredox beta-thiol-alpha-carbonylation of enones accompanied by unexpected Csp2-C(CO) bond cleavage.	enones	45-51	regulator of calcineurin 2	Homo sapiens	78-82
32960201-2	2020	A novel reactivity was showcased in conjunction with the selective Csp2-C(CO) bond activation of enones, which provided a convenient method for the preparation of various beta-thiolated-alpha-functionalized compounds.	enones	97-103	regulator of calcineurin 2	Homo sapiens	67-71
29565132-1	2018	A facile method for the synthesis of gamma-sulfur-substituted ketones is developed via a Rh(II)/Sc(III) cocatalyzed three-component reaction of diazo compounds with thiophenols and enones.	enones	181-187	Rh blood group D antigen	Homo sapiens	89-95
26473619-2	2015	Cooperative catalysis by [Au(ItBu)NTf2] and AgNTf2 enables the synthesis of a range of densely functionalized alpha-allylated enals, enones, and acyl silanes in good yield under mild reaction conditions.	enones	133-139	nuclear transport factor 2	Homo sapiens	34-38
26561034-0	2015	Palladium(0)/NHC-Catalyzed Reductive Heck Reaction of Enones: A Detailed Mechanistic Study.	enones	54-60	high mobility group nucleosomal binding domain 4	Homo sapiens	13-16
29223100-10	2018	Dose-response studies demonstrated that a range of substituents on the aromatic rings of these enones influenced not only the sensitivity to activation, reflected in EC50 values, but also the extent of activation, which suggests that multiple mechanisms are involved in the activation of Nrf2 by these analogues.	enones	95-101	NFE2 like bZIP transcription factor 2	Homo sapiens	288-292
27251045-2	2016	These enones are cytotoxic to human CD4(+ )T-lymphocyte Molt 4/C8 and CEM and murine leukemia L1210 cells.	enones	6-12	CD4 molecule	Homo sapiens	36-39
25093760-0	2014	Rh(II)/Bronsted acid cocatalyzed intramolecular trapping of ammonium ylides with enones: diastereoselective synthesis of 2,2,3-trisubstituted indolines.	enones	81-87	Rh blood group D antigen	Homo sapiens	0-6
26291733-0	2015	P(NMe2)3-mediated reductive [1+4] annulation of isatins with enones: a facile synthesis of spirooxindole-dihydrofurans.	enones	61-67	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	2-6
26291733-1	2015	A novel P(NMe2)3-mediated reductive [1+4] annulation reaction between isatins and enones has been developed, providing the facile synthesis of spirooxindole-dihydrofurans.	enones	82-88	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	10-14
25093760-1	2014	Highly diastereoselective intramolecular trapping of ammonium ylides with enones has been developed through a Rh(II)/Bronsted acid cocatalytic strategy.	enones	74-80	Rh blood group D antigen	Homo sapiens	110-116
22357344-1	2012	Progesterone 5beta-reductases (P5betaR; EC 1.3.99.6) encoded by Vein Patterning 1 (VEP1) genes are capable of reducing the CC double-bond of a variety of enones enantioselectively.	enones	154-160	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	64-81
22900473-2	2012	For enones as substrates, products of a beta-chloro-alpha-aminoxylation are obtained (70-89%).	enones	4-10	amyloid beta precursor protein	Homo sapiens	38-44
24309193-1	2014	Mild and regioselective conversion of 3-keto-5alpha- and 3-keto-5beta-steroids (trans A/B- and cis A/B-ring juncture, respectively) to the corresponding enones (Delta(1)- and Delta(4)-3-ketones) by treatment with o-iodoxybenzoic acid (IBX) catalyzed by trifluoroacetic acid (TFA) in DMSO, is described.	enones	153-159	delta like non-canonical Notch ligand 1	Homo sapiens	161-185
22357344-1	2012	Progesterone 5beta-reductases (P5betaR; EC 1.3.99.6) encoded by Vein Patterning 1 (VEP1) genes are capable of reducing the CC double-bond of a variety of enones enantioselectively.	enones	154-160	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	83-87
21472183-1	2011	Asymmetric Michael reactions of thiols with enones were catalyzed by a Sc(OTf)(3)-chiral bipyridine complex at room temperature in water without using any organic solvents, to afford the desired sulfides in high yields with high enantioselectivities.	enones	44-50	POU class 5 homeobox 1	Homo sapiens	71-80
21370873-2	2011	Sc(OTf)(3) and Y(OTf)(3) promoted the direct addition of alkyl-substituted azaarenes and benzoxazole to enones and an alpha,beta-unsaturated N-acylpyrrole.	enones	104-110	POU class 5 homeobox 1	Homo sapiens	0-9
20966958-0	2010	Catalytic enantioselective syn hydration of enones in water using a DNA-based catalyst.	enones	44-50	synemin	Homo sapiens	27-30
21491928-5	2011	Biological evaluation of the natural-product-derived enones led to the identification of a derivative of (-)-eburnamonine with significant cytotoxicity (LC(50) = 14.12 muM) in drug-resistant MDA-MB-231 breast cancer cells.	enones	53-59	latexin	Homo sapiens	168-171
20411973-0	2010	Primary amine/(+)-CSA salt-promoted organocatalytic conjugate addition of nitro esters to enones.	enones	90-96	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	18-21
20024150-4	2010	The absolute configuration of the major products indicates enones to react in the syn-s-trans orientation.	enones	59-65	synemin	Homo sapiens	82-85
18343189-5	2008	beta-Substituents in fluorinated enones such as R(2)=H, C(6)H(5), and C(CH(3))(3) assist in the intermolecular hydrogen bond formation of the carbonyl moiety with HBD solvents, while beta-substituents such as CH(3) and 4-NO(2)C(6)H(4) prevent the CO group to form the H-bonds with HBD solvents (the solvent HBD acidity term (alpha) is not significant).	enones	33-39	HBD	Homo sapiens	163-166
18343189-5	2008	beta-Substituents in fluorinated enones such as R(2)=H, C(6)H(5), and C(CH(3))(3) assist in the intermolecular hydrogen bond formation of the carbonyl moiety with HBD solvents, while beta-substituents such as CH(3) and 4-NO(2)C(6)H(4) prevent the CO group to form the H-bonds with HBD solvents (the solvent HBD acidity term (alpha) is not significant).	enones	33-39	HBD	Homo sapiens	281-284