PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32976922-0	2020	Picroside II alleviates liver injury induced by alpha-naphthylisothiocyanate through AMPK-FXR pathway.	picroside II	0-12	nuclear receptor subfamily 1, group H, member 4	Mus musculus	90-93
32018210-13	2020	Dual-luciferase reporter assay performed in HepG2 cells demonstrated FXR activation by picroside II.	picroside II	87-99	nuclear receptor subfamily 1 group H member 4	Homo sapiens	69-72
32351672-4	2020	We hypothesized that picroside II will have protective effects against pancreatitis-induced intestinal barrier injury by affecting oxidative and inflammatory signaling (Toll-like receptor 4- (TLR4-) dependent phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and nuclear factor kappa B (NF-kappaB)).	picroside II	21-33	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	209-238
32351672-4	2020	We hypothesized that picroside II will have protective effects against pancreatitis-induced intestinal barrier injury by affecting oxidative and inflammatory signaling (Toll-like receptor 4- (TLR4-) dependent phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and nuclear factor kappa B (NF-kappaB)).	picroside II	21-33	AKT serine/threonine kinase 1	Rattus norvegicus	265-268
32018210-10	2020	Picroside II increased bile acid efflux transporter bile salt export pump (Bsep), uptake transporter sodium taurocholate cotransporting polypeptide (Ntcp), and bile acid metabolizing enzymes sulfate transferase 2a1 (Sult2a1) and UDP-glucuronosyltransferase 1a1 (Ugt1a1), whereas decreased the bile acid synthesis enzymes cholesterol 7alpha-hydroxylase (Cyp7a1) and oxysterol 12alpha-hydroxylase (Cyp8b1).	picroside II	0-12	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	353-359
32018210-10	2020	Picroside II increased bile acid efflux transporter bile salt export pump (Bsep), uptake transporter sodium taurocholate cotransporting polypeptide (Ntcp), and bile acid metabolizing enzymes sulfate transferase 2a1 (Sult2a1) and UDP-glucuronosyltransferase 1a1 (Ugt1a1), whereas decreased the bile acid synthesis enzymes cholesterol 7alpha-hydroxylase (Cyp7a1) and oxysterol 12alpha-hydroxylase (Cyp8b1).	picroside II	0-12	cytochrome P450, family 8, subfamily b, polypeptide 1	Mus musculus	396-402
32018210-11	2020	In addition, expression of FXR and the target gene Bsep was increased, whereas aryl hydrocarbon receptor (AhR), pregnane X receptor (PXR), peroxisome proliferator-activated receptor alpha (PPARalpha) and their corresponding target genes were not significantly influenced by picroside II under cholestatic conditions.	picroside II	274-286	nuclear receptor subfamily 1, group H, member 4	Mus musculus	27-30
32351672-0	2020	Picroside II Improves Severe Acute Pancreatitis-Induced Intestinal Barrier Injury by Inactivating Oxidative and Inflammatory TLR4-Dependent PI3K/AKT/NF-kappaB Signaling and Improving Gut Microbiota.	picroside II	0-12	toll-like receptor 4	Rattus norvegicus	125-129
32351672-0	2020	Picroside II Improves Severe Acute Pancreatitis-Induced Intestinal Barrier Injury by Inactivating Oxidative and Inflammatory TLR4-Dependent PI3K/AKT/NF-kappaB Signaling and Improving Gut Microbiota.	picroside II	0-12	AKT serine/threonine kinase 1	Rattus norvegicus	145-148
32351672-4	2020	We hypothesized that picroside II will have protective effects against pancreatitis-induced intestinal barrier injury by affecting oxidative and inflammatory signaling (Toll-like receptor 4- (TLR4-) dependent phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and nuclear factor kappa B (NF-kappaB)).	picroside II	21-33	toll-like receptor 4	Rattus norvegicus	169-189
32351672-4	2020	We hypothesized that picroside II will have protective effects against pancreatitis-induced intestinal barrier injury by affecting oxidative and inflammatory signaling (Toll-like receptor 4- (TLR4-) dependent phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and nuclear factor kappa B (NF-kappaB)).	picroside II	21-33	toll-like receptor 4	Rattus norvegicus	192-196
32018210-0	2020	Picroside II protects against cholestatic liver injury possibly through activation of farnesoid X receptor.	picroside II	0-12	nuclear receptor subfamily 1, group H, member 4	Mus musculus	86-106
32018210-8	2020	siRNA, Dual-luciferase reporter, quantitative real-time PCR and Western blot assay were used to demonstrate the farnesoid X receptor (FXR) pathway in the anti-cholestasis effects of picroside II in vivo and in vitro.	picroside II	182-194	nuclear receptor subfamily 1, group H, member 4	Mus musculus	112-132
32018210-8	2020	siRNA, Dual-luciferase reporter, quantitative real-time PCR and Western blot assay were used to demonstrate the farnesoid X receptor (FXR) pathway in the anti-cholestasis effects of picroside II in vivo and in vitro.	picroside II	182-194	nuclear receptor subfamily 1, group H, member 4	Mus musculus	134-137
32018210-10	2020	Picroside II increased bile acid efflux transporter bile salt export pump (Bsep), uptake transporter sodium taurocholate cotransporting polypeptide (Ntcp), and bile acid metabolizing enzymes sulfate transferase 2a1 (Sult2a1) and UDP-glucuronosyltransferase 1a1 (Ugt1a1), whereas decreased the bile acid synthesis enzymes cholesterol 7alpha-hydroxylase (Cyp7a1) and oxysterol 12alpha-hydroxylase (Cyp8b1).	picroside II	0-12	ATP-binding cassette, sub-family B (MDR/TAP), member 11	Mus musculus	52-73
32018210-10	2020	Picroside II increased bile acid efflux transporter bile salt export pump (Bsep), uptake transporter sodium taurocholate cotransporting polypeptide (Ntcp), and bile acid metabolizing enzymes sulfate transferase 2a1 (Sult2a1) and UDP-glucuronosyltransferase 1a1 (Ugt1a1), whereas decreased the bile acid synthesis enzymes cholesterol 7alpha-hydroxylase (Cyp7a1) and oxysterol 12alpha-hydroxylase (Cyp8b1).	picroside II	0-12	ATP-binding cassette, sub-family B (MDR/TAP), member 11	Mus musculus	75-79
32018210-10	2020	Picroside II increased bile acid efflux transporter bile salt export pump (Bsep), uptake transporter sodium taurocholate cotransporting polypeptide (Ntcp), and bile acid metabolizing enzymes sulfate transferase 2a1 (Sult2a1) and UDP-glucuronosyltransferase 1a1 (Ugt1a1), whereas decreased the bile acid synthesis enzymes cholesterol 7alpha-hydroxylase (Cyp7a1) and oxysterol 12alpha-hydroxylase (Cyp8b1).	picroside II	0-12	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	Mus musculus	149-153
32018210-10	2020	Picroside II increased bile acid efflux transporter bile salt export pump (Bsep), uptake transporter sodium taurocholate cotransporting polypeptide (Ntcp), and bile acid metabolizing enzymes sulfate transferase 2a1 (Sult2a1) and UDP-glucuronosyltransferase 1a1 (Ugt1a1), whereas decreased the bile acid synthesis enzymes cholesterol 7alpha-hydroxylase (Cyp7a1) and oxysterol 12alpha-hydroxylase (Cyp8b1).	picroside II	0-12	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	Mus musculus	216-223
32018210-10	2020	Picroside II increased bile acid efflux transporter bile salt export pump (Bsep), uptake transporter sodium taurocholate cotransporting polypeptide (Ntcp), and bile acid metabolizing enzymes sulfate transferase 2a1 (Sult2a1) and UDP-glucuronosyltransferase 1a1 (Ugt1a1), whereas decreased the bile acid synthesis enzymes cholesterol 7alpha-hydroxylase (Cyp7a1) and oxysterol 12alpha-hydroxylase (Cyp8b1).	picroside II	0-12	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	229-260
32018210-10	2020	Picroside II increased bile acid efflux transporter bile salt export pump (Bsep), uptake transporter sodium taurocholate cotransporting polypeptide (Ntcp), and bile acid metabolizing enzymes sulfate transferase 2a1 (Sult2a1) and UDP-glucuronosyltransferase 1a1 (Ugt1a1), whereas decreased the bile acid synthesis enzymes cholesterol 7alpha-hydroxylase (Cyp7a1) and oxysterol 12alpha-hydroxylase (Cyp8b1).	picroside II	0-12	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	262-268
32018210-10	2020	Picroside II increased bile acid efflux transporter bile salt export pump (Bsep), uptake transporter sodium taurocholate cotransporting polypeptide (Ntcp), and bile acid metabolizing enzymes sulfate transferase 2a1 (Sult2a1) and UDP-glucuronosyltransferase 1a1 (Ugt1a1), whereas decreased the bile acid synthesis enzymes cholesterol 7alpha-hydroxylase (Cyp7a1) and oxysterol 12alpha-hydroxylase (Cyp8b1).	picroside II	0-12	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	321-351
32018210-14	2020	CONCLUSION: Our findings demonstrate that picroside II exerts protective effect on ANIT-induced cholestasis possibly through FXR activation that regulates the transporters and enzymes involved in bile acid homeostasis.	picroside II	42-54	nuclear receptor subfamily 1 group H member 4	Homo sapiens	125-128
31251836-0	2019	Picroside II Protects SH-SY5Y Cells From Autophagy and Apoptosis Following Oxygen Glucose Deprivation/Reoxygen Injury by Inhibiting JNK Signal Pathway.	picroside II	0-12	mitogen-activated protein kinase 8	Homo sapiens	132-135
31859816-8	2019	The activities of HO-1, MPO, NOX, XO and MDA content were increased and the SOD activity was decreased in l/R (P<0.05) and could be reversed by Picroside II (P=0.03, 405.5+-7.5 vs. 304+-17U/mgprot; P=0.02, 0.99+-0.05 vs. 0.52+-0.04 mgprot; P=0.01, 260+7 vs. 189+-2 mgprot; P=0.04, 10.95+0.55 vs. 8.75+0.35 U/mgprot; P=0.045, 6.8+0.7 vs. 3.75+0.35 mgprot; P=0.04, 44.5+3.5 vs. 57.5+3.5 mgprot).	picroside II	147-159	heme oxygenase 1	Rattus norvegicus	18-22
31859816-8	2019	The activities of HO-1, MPO, NOX, XO and MDA content were increased and the SOD activity was decreased in l/R (P<0.05) and could be reversed by Picroside II (P=0.03, 405.5+-7.5 vs. 304+-17U/mgprot; P=0.02, 0.99+-0.05 vs. 0.52+-0.04 mgprot; P=0.01, 260+7 vs. 189+-2 mgprot; P=0.04, 10.95+0.55 vs. 8.75+0.35 U/mgprot; P=0.045, 6.8+0.7 vs. 3.75+0.35 mgprot; P=0.04, 44.5+3.5 vs. 57.5+3.5 mgprot).	picroside II	147-159	myeloperoxidase	Rattus norvegicus	24-27
31859816-9	2019	Western blot showed that the expression of iNOS, nNOS and eNOS were increased in l/R (P<0.05); however, they were decreased after Picroside II treatment (P<0.05).	picroside II	133-145	nitric oxide synthase 2	Rattus norvegicus	43-47
31859816-9	2019	Western blot showed that the expression of iNOS, nNOS and eNOS were increased in l/R (P<0.05); however, they were decreased after Picroside II treatment (P<0.05).	picroside II	133-145	nitric oxide synthase 1	Rattus norvegicus	49-53
31137813-7	2019	In this study, we investigated whether picroside II is effective in treating steroid refractory lung inflammation via the inhibition of the SAA-IL-33 axis.	picroside II	39-51	serum amyloid A1 cluster	Homo sapiens	140-143
31137813-7	2019	In this study, we investigated whether picroside II is effective in treating steroid refractory lung inflammation via the inhibition of the SAA-IL-33 axis.	picroside II	39-51	interleukin 33	Homo sapiens	144-149
31137813-8	2019	Picroside II inhibited LPS-induced SAA1 expression in human monocytes, which are resistant to steroids.	picroside II	0-12	serum amyloid A1	Homo sapiens	35-39
31137813-10	2019	Picroside II, but not dexamethasone effectively inhibited SAA-induced IL-33 expression and secretion.	picroside II	0-12	serum amyloid A1 cluster	Homo sapiens	58-61
31137813-10	2019	Picroside II, but not dexamethasone effectively inhibited SAA-induced IL-33 expression and secretion.	picroside II	0-12	interleukin 33	Homo sapiens	70-75
31137813-11	2019	The inhibitory effect by picroside II was mediated by suppressing the mitogen-activated protein kinase (MAPK) p38, ERK1/2, and nuclear factor-kappaB pathways.	picroside II	25-37	mitogen-activated protein kinase 3	Homo sapiens	104-108
31137813-11	2019	The inhibitory effect by picroside II was mediated by suppressing the mitogen-activated protein kinase (MAPK) p38, ERK1/2, and nuclear factor-kappaB pathways.	picroside II	25-37	mitogen-activated protein kinase 1	Homo sapiens	110-113
31137813-11	2019	The inhibitory effect by picroside II was mediated by suppressing the mitogen-activated protein kinase (MAPK) p38, ERK1/2, and nuclear factor-kappaB pathways.	picroside II	25-37	mitogen-activated protein kinase 3	Homo sapiens	115-121
30526784-12	2018	Conclusion: It is suggested that picroside II could exert antioxidation to protect the brain tissue through inhibiting the expression of Rac-1 and Nox2.	picroside II	33-45	Rac family small GTPase 1	Rattus norvegicus	137-142
30526784-12	2018	Conclusion: It is suggested that picroside II could exert antioxidation to protect the brain tissue through inhibiting the expression of Rac-1 and Nox2.	picroside II	33-45	cytochrome b-245 beta chain	Rattus norvegicus	147-151
28441724-7	2017	Metabolism of picroside II (M4) into M4 sulfate (M8) was catalyzed by SULT1A1, SULT1E1, SULT1A2, SULT1A3, and SULT1C4.	picroside II	14-26	sulfotransferase family 1A member 1	Homo sapiens	70-77
29343040-0	2018	[Effect of picroside II on the expression of mitochondrial VDAC1 after cerebral ischemia/reperfusion in rats].	picroside II	11-23	voltage-dependent anion channel 1	Rattus norvegicus	59-64
29343040-1	2018	Objective: To explore the effect of picroside II on the expression of mitochondrial voltage-dependent anion channel 1 (VDAC1) in rats after cerebral ischemiareperfusion.	picroside II	36-48	voltage-dependent anion channel 1	Rattus norvegicus	119-124
28464271-0	2017	Picroside II Inhibits RANKL-Mediated Osteoclastogenesis by Attenuating the NF-kappaB and MAPKs Signaling Pathway In Vitro and Prevents Bone Loss in Lipopolysaccharide Treatment Mice.	picroside II	0-12	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	22-27
28464271-6	2017	Results demonstrated picroside II strongly inhibited RANKL-induced osteoclast formation when added during the early stage of BMMs cultures, suggesting that it acts on osteoclast precursors to inhibit RANKL/RANK signaling.	picroside II	21-33	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	53-58
28464271-6	2017	Results demonstrated picroside II strongly inhibited RANKL-induced osteoclast formation when added during the early stage of BMMs cultures, suggesting that it acts on osteoclast precursors to inhibit RANKL/RANK signaling.	picroside II	21-33	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	200-205
28464271-7	2017	Moreover, picroside II markedly decreased the phosphorylation of p38, ERK, JNK, p65, and I-kappaB degradation, and significantly suppressed c-Fos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), both the key transcription factors during osteoclastogenesis.	picroside II	10-22	mitogen-activated protein kinase 14	Mus musculus	65-68
28464271-7	2017	Moreover, picroside II markedly decreased the phosphorylation of p38, ERK, JNK, p65, and I-kappaB degradation, and significantly suppressed c-Fos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), both the key transcription factors during osteoclastogenesis.	picroside II	10-22	mitogen-activated protein kinase 1	Mus musculus	70-73
28464271-7	2017	Moreover, picroside II markedly decreased the phosphorylation of p38, ERK, JNK, p65, and I-kappaB degradation, and significantly suppressed c-Fos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), both the key transcription factors during osteoclastogenesis.	picroside II	10-22	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	80-83
28464271-7	2017	Moreover, picroside II markedly decreased the phosphorylation of p38, ERK, JNK, p65, and I-kappaB degradation, and significantly suppressed c-Fos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), both the key transcription factors during osteoclastogenesis.	picroside II	10-22	FBJ osteosarcoma oncogene	Mus musculus	140-145
28464271-7	2017	Moreover, picroside II markedly decreased the phosphorylation of p38, ERK, JNK, p65, and I-kappaB degradation, and significantly suppressed c-Fos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), both the key transcription factors during osteoclastogenesis.	picroside II	10-22	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	150-199
28464271-7	2017	Moreover, picroside II markedly decreased the phosphorylation of p38, ERK, JNK, p65, and I-kappaB degradation, and significantly suppressed c-Fos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), both the key transcription factors during osteoclastogenesis.	picroside II	10-22	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	201-207
28161732-5	2017	Results showed picroside II significantly decreased the concentrations of TNF-alpha, IL-1beta, and IL-6 in cells and mice.	picroside II	15-27	tumor necrosis factor	Mus musculus	74-83
28161732-5	2017	Results showed picroside II significantly decreased the concentrations of TNF-alpha, IL-1beta, and IL-6 in cells and mice.	picroside II	15-27	interleukin 1 beta	Mus musculus	85-93
28161732-5	2017	Results showed picroside II significantly decreased the concentrations of TNF-alpha, IL-1beta, and IL-6 in cells and mice.	picroside II	15-27	interleukin 6	Mus musculus	99-103
29256102-0	2018	Picroside II Exerts a Neuroprotective Effect by Inhibiting mPTP Permeability and EndoG Release after Cerebral Ischemia/Reperfusion Injury in Rats.	picroside II	0-12	protein tyrosine phosphatase, receptor type, U	Mus musculus	59-63
29256102-0	2018	Picroside II Exerts a Neuroprotective Effect by Inhibiting mPTP Permeability and EndoG Release after Cerebral Ischemia/Reperfusion Injury in Rats.	picroside II	0-12	endonuclease G	Rattus norvegicus	81-86
28441724-7	2017	Metabolism of picroside II (M4) into M4 sulfate (M8) was catalyzed by SULT1A1, SULT1E1, SULT1A2, SULT1A3, and SULT1C4.	picroside II	14-26	sulfotransferase family 1E member 1	Homo sapiens	79-86
28441724-7	2017	Metabolism of picroside II (M4) into M4 sulfate (M8) was catalyzed by SULT1A1, SULT1E1, SULT1A2, SULT1A3, and SULT1C4.	picroside II	14-26	sulfotransferase family 1A member 2	Homo sapiens	88-95
28441724-7	2017	Metabolism of picroside II (M4) into M4 sulfate (M8) was catalyzed by SULT1A1, SULT1E1, SULT1A2, SULT1A3, and SULT1C4.	picroside II	14-26	sulfotransferase family 1A member 3	Homo sapiens	97-104
28441724-7	2017	Metabolism of picroside II (M4) into M4 sulfate (M8) was catalyzed by SULT1A1, SULT1E1, SULT1A2, SULT1A3, and SULT1C4.	picroside II	14-26	sulfotransferase family 1C member 4	Homo sapiens	110-117
28078023-5	2016	Further, picroside II treatment alleviated the inflammatory response in sepsis and enhanced immune function by inhibiting the activation of NLRP3 inflammasome and NF-kappaB pathways.	picroside II	9-21	NLR family, pyrin domain containing 3	Mus musculus	140-145
28388666-9	2017	CONCLUSIONS: Picroside II could protect the nervous system possibly through reducing the content of ROS by down-regulating the expression of Rac-1 and Nox2 and could protect the BBB through reducing the expression of ROCK, MLCK, and MMP-2, while enhancing the expression of claudin-5.	picroside II	13-25	Rac family small GTPase 1	Homo sapiens	141-146
28388666-9	2017	CONCLUSIONS: Picroside II could protect the nervous system possibly through reducing the content of ROS by down-regulating the expression of Rac-1 and Nox2 and could protect the BBB through reducing the expression of ROCK, MLCK, and MMP-2, while enhancing the expression of claudin-5.	picroside II	13-25	cytochrome b-245 beta chain	Homo sapiens	151-155
28388666-9	2017	CONCLUSIONS: Picroside II could protect the nervous system possibly through reducing the content of ROS by down-regulating the expression of Rac-1 and Nox2 and could protect the BBB through reducing the expression of ROCK, MLCK, and MMP-2, while enhancing the expression of claudin-5.	picroside II	13-25	myosin light chain kinase 3	Homo sapiens	223-227
28388666-9	2017	CONCLUSIONS: Picroside II could protect the nervous system possibly through reducing the content of ROS by down-regulating the expression of Rac-1 and Nox2 and could protect the BBB through reducing the expression of ROCK, MLCK, and MMP-2, while enhancing the expression of claudin-5.	picroside II	13-25	matrix metallopeptidase 2	Homo sapiens	233-238
28388666-9	2017	CONCLUSIONS: Picroside II could protect the nervous system possibly through reducing the content of ROS by down-regulating the expression of Rac-1 and Nox2 and could protect the BBB through reducing the expression of ROCK, MLCK, and MMP-2, while enhancing the expression of claudin-5.	picroside II	13-25	claudin 5	Homo sapiens	274-283
28713490-10	2017	The results showed that picroside II treatment reduced the level of ALT, AST, NF-kappaB, IL-1beta, IL-6, TNF-alpha, and SIRT1 (NAD+-dependent deacetylase) and increased the level of SOD and GSH.	picroside II	24-36	interleukin 1 beta	Rattus norvegicus	89-97
28713490-10	2017	The results showed that picroside II treatment reduced the level of ALT, AST, NF-kappaB, IL-1beta, IL-6, TNF-alpha, and SIRT1 (NAD+-dependent deacetylase) and increased the level of SOD and GSH.	picroside II	24-36	interleukin 6	Rattus norvegicus	99-103
28713490-10	2017	The results showed that picroside II treatment reduced the level of ALT, AST, NF-kappaB, IL-1beta, IL-6, TNF-alpha, and SIRT1 (NAD+-dependent deacetylase) and increased the level of SOD and GSH.	picroside II	24-36	tumor necrosis factor	Rattus norvegicus	105-114
28713490-10	2017	The results showed that picroside II treatment reduced the level of ALT, AST, NF-kappaB, IL-1beta, IL-6, TNF-alpha, and SIRT1 (NAD+-dependent deacetylase) and increased the level of SOD and GSH.	picroside II	24-36	sirtuin 1	Rattus norvegicus	120-125
28054226-5	2017	The results indicated that picroside II could scavenge ROS contents, decrease the cerebral infarction volume and apoptotic cells, protect the structure of mitochondria, down-regulate the expression of CytC and Caspase-3 in cerebral I/R rats.	picroside II	27-39	caspase 3	Rattus norvegicus	210-219
28107518-0	2017	Correction: Picroside II Attenuates Airway Inflammation by Downregulating the Transcription Factor GATA3 and Th2-Related Cytokines in a Mouse Model of HDM-Induced Allergic Asthma.	picroside II	12-24	GATA binding protein 3	Mus musculus	99-104
28107518-0	2017	Correction: Picroside II Attenuates Airway Inflammation by Downregulating the Transcription Factor GATA3 and Th2-Related Cytokines in a Mouse Model of HDM-Induced Allergic Asthma.	picroside II	12-24	heart and neural crest derivatives expressed 2	Mus musculus	109-112
27870920-0	2016	Picroside II Attenuates Airway Inflammation by Downregulating the Transcription Factor GATA3 and Th2-Related Cytokines in a Mouse Model of HDM-Induced Allergic Asthma.	picroside II	0-12	GATA binding protein 3	Mus musculus	87-92
28105084-7	2016	In addition, picroside II was also able to decrease high mobility group box 1 (HMGB1) expression, and release and downregulate the expression of the receptor for advanced glycation end products (RAGE), toll-like receptor (TLR)-2 and TLR-4.	picroside II	13-25	high mobility group box 1	Rattus norvegicus	52-77
28105084-7	2016	In addition, picroside II was also able to decrease high mobility group box 1 (HMGB1) expression, and release and downregulate the expression of the receptor for advanced glycation end products (RAGE), toll-like receptor (TLR)-2 and TLR-4.	picroside II	13-25	high mobility group box 1	Rattus norvegicus	79-84
28105084-7	2016	In addition, picroside II was also able to decrease high mobility group box 1 (HMGB1) expression, and release and downregulate the expression of the receptor for advanced glycation end products (RAGE), toll-like receptor (TLR)-2 and TLR-4.	picroside II	13-25	advanced glycosylation end product-specific receptor	Rattus norvegicus	149-193
28105084-7	2016	In addition, picroside II was also able to decrease high mobility group box 1 (HMGB1) expression, and release and downregulate the expression of the receptor for advanced glycation end products (RAGE), toll-like receptor (TLR)-2 and TLR-4.	picroside II	13-25	advanced glycosylation end product-specific receptor	Rattus norvegicus	195-199
28105084-7	2016	In addition, picroside II was also able to decrease high mobility group box 1 (HMGB1) expression, and release and downregulate the expression of the receptor for advanced glycation end products (RAGE), toll-like receptor (TLR)-2 and TLR-4.	picroside II	13-25	toll-like receptor 2	Rattus norvegicus	202-228
28105084-7	2016	In addition, picroside II was also able to decrease high mobility group box 1 (HMGB1) expression, and release and downregulate the expression of the receptor for advanced glycation end products (RAGE), toll-like receptor (TLR)-2 and TLR-4.	picroside II	13-25	toll-like receptor 4	Rattus norvegicus	233-238
27870920-6	2016	Picroside II also inhibited the expression of Th2 type cytokine genes and the transcription factor GATA3 in the lung tissues of HDM-induced mice.	picroside II	0-12	GATA binding protein 3	Mus musculus	99-104
27870920-7	2016	Finally, we demonstrated that picroside II significantly decreased the expression of GATA3 and Th2 cytokines in developing Th2 cells, consistent with in vivo results.	picroside II	30-42	GATA binding protein 3	Mus musculus	85-90
27870920-7	2016	Finally, we demonstrated that picroside II significantly decreased the expression of GATA3 and Th2 cytokines in developing Th2 cells, consistent with in vivo results.	picroside II	30-42	heart and neural crest derivatives expressed 2	Mus musculus	95-98
27870920-7	2016	Finally, we demonstrated that picroside II significantly decreased the expression of GATA3 and Th2 cytokines in developing Th2 cells, consistent with in vivo results.	picroside II	30-42	heart and neural crest derivatives expressed 2	Mus musculus	123-126
27870920-8	2016	Taken together, these results indicate that picroside II has protective effects on allergic asthma by reducing GATA3 expression and Th2 cytokine bias.	picroside II	44-56	GATA binding protein 3	Mus musculus	111-116
27870920-8	2016	Taken together, these results indicate that picroside II has protective effects on allergic asthma by reducing GATA3 expression and Th2 cytokine bias.	picroside II	44-56	heart and neural crest derivatives expressed 2	Mus musculus	132-135
27870920-0	2016	Picroside II Attenuates Airway Inflammation by Downregulating the Transcription Factor GATA3 and Th2-Related Cytokines in a Mouse Model of HDM-Induced Allergic Asthma.	picroside II	0-12	heart and neural crest derivatives expressed 2	Mus musculus	97-100
27870920-4	2016	In the HDM-induced asthmatic model, picroside II significantly reduced inflammatory cell counts in the bronchoalveolar lavage fluid (BALF), the levels of total immunoglobulin (Ig) E and HDM-specific IgE and IgG1 in serum, airway inflammation, and mucus hypersecretion in the lung tissues.	picroside II	36-48	LOC105243590	Mus musculus	207-211
27870920-6	2016	Picroside II also inhibited the expression of Th2 type cytokine genes and the transcription factor GATA3 in the lung tissues of HDM-induced mice.	picroside II	0-12	heart and neural crest derivatives expressed 2	Mus musculus	46-49
25780418-0	2015	Picroside II protects rat kidney against ischemia/reperfusion-induced oxidative stress and inflammation by the TLR4/NF-kappaB pathway.	picroside II	0-12	toll-like receptor 4	Rattus norvegicus	111-115
27323616-0	2016	[Effect of Picroside II on ERK1/2 Signal Pathway in Cerebral lschemic Injury Rats].	picroside II	11-23	mitogen activated protein kinase 3	Rattus norvegicus	27-33
27323616-1	2016	OBJECTIVE: To explore the neuroprotective effect and mechanism of picroside II on extracellular regulated protein kinases1/2 (ERK1/2) signal transduction pathway in cerebral ischemia injuryrats.	picroside II	66-78	mitogen activated protein kinase 3	Rattus norvegicus	126-132
26240040-0	2015	Picroside II Inhibits the MEK-ERK1/2-COX2 Signal Pathway to Prevent Cerebral Ischemic Injury in Rats.	picroside II	0-12	mitogen activated protein kinase 3	Rattus norvegicus	30-36
26240040-0	2015	Picroside II Inhibits the MEK-ERK1/2-COX2 Signal Pathway to Prevent Cerebral Ischemic Injury in Rats.	picroside II	0-12	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	37-41
26240040-10	2015	In LPS group, neuron damage was extensive, pMEK1/2, pERK1/2, and COX2 expression was still at a high level, and COX2 mRNA peak arrived at ischemic 12 h. Picroside II downregulates COX2 expression after MCAO by inhibiting MEK-ERK1/2 in rats to protect neurons from apoptosis and inflammation.	picroside II	153-165	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	65-69
26240040-10	2015	In LPS group, neuron damage was extensive, pMEK1/2, pERK1/2, and COX2 expression was still at a high level, and COX2 mRNA peak arrived at ischemic 12 h. Picroside II downregulates COX2 expression after MCAO by inhibiting MEK-ERK1/2 in rats to protect neurons from apoptosis and inflammation.	picroside II	153-165	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	112-116
26240040-10	2015	In LPS group, neuron damage was extensive, pMEK1/2, pERK1/2, and COX2 expression was still at a high level, and COX2 mRNA peak arrived at ischemic 12 h. Picroside II downregulates COX2 expression after MCAO by inhibiting MEK-ERK1/2 in rats to protect neurons from apoptosis and inflammation.	picroside II	153-165	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	112-116
26240040-10	2015	In LPS group, neuron damage was extensive, pMEK1/2, pERK1/2, and COX2 expression was still at a high level, and COX2 mRNA peak arrived at ischemic 12 h. Picroside II downregulates COX2 expression after MCAO by inhibiting MEK-ERK1/2 in rats to protect neurons from apoptosis and inflammation.	picroside II	153-165	mitogen activated protein kinase 3	Rattus norvegicus	53-59
26175147-0	2015	Picroside II has a neuroprotective effect by inhibiting ERK1/2 activation after cerebral ischemic injury in rats.	picroside II	0-12	mitogen activated protein kinase 3	Rattus norvegicus	56-62
26175147-12	2015	The results suggest that activation of ERK1/2 in cerebral ischaemia induces neuronal apoptosis and picroside II may reduce neuronal apoptosis to confer protection against cerebral ischemic injury by inhibiting ERK1/2 activation.	picroside II	99-111	mitogen activated protein kinase 3	Rattus norvegicus	39-45
26175147-12	2015	The results suggest that activation of ERK1/2 in cerebral ischaemia induces neuronal apoptosis and picroside II may reduce neuronal apoptosis to confer protection against cerebral ischemic injury by inhibiting ERK1/2 activation.	picroside II	99-111	mitogen activated protein kinase 3	Rattus norvegicus	210-216
25780418-9	2015	Morphological analysis indicated that picroside II clearly reduced tissue damage and the expression of TLR4 and NF-kappaB.	picroside II	38-50	toll-like receptor 4	Rattus norvegicus	103-107
25780418-10	2015	Reverse transcription-quantitative polymerase chain reaction demonstrated that picroside II inhibited the increase of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and intercellular adhesion molecule (ICAM)-1 expression induced by I/R injury.	picroside II	79-91	tumor necrosis factor	Rattus norvegicus	118-151
25780418-10	2015	Reverse transcription-quantitative polymerase chain reaction demonstrated that picroside II inhibited the increase of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and intercellular adhesion molecule (ICAM)-1 expression induced by I/R injury.	picroside II	79-91	interleukin 1 beta	Rattus norvegicus	153-175
25780418-10	2015	Reverse transcription-quantitative polymerase chain reaction demonstrated that picroside II inhibited the increase of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and intercellular adhesion molecule (ICAM)-1 expression induced by I/R injury.	picroside II	79-91	intercellular adhesion molecule 1	Rattus norvegicus	180-220
25780418-11	2015	Western blot analysis indicated that the expression levels of TLR4 and NF-kappaB were significantly downregulated in the picroside II group compared with those in the I/R group.	picroside II	121-133	toll-like receptor 4	Rattus norvegicus	62-66
25780418-12	2015	These results indicate that picroside II treatment suppressed the TLR4/NF-kappaB signaling pathway, protecting renal tissue against I/R-induced oxidative stress and inflammatory response.	picroside II	28-40	toll-like receptor 4	Rattus norvegicus	66-70
25421707-6	2015	In addition, picroside II was also able to decrease the opening degree of mitochondrial permeability transition pore (mPTP), increase the mitochondrial membrane potential, inhibit cytochrome c release from mitochondria to cytosol and downregulate caspase-3 expression and activity concomitantly with the decreased ROS production.	picroside II	13-25	caspase 3	Rattus norvegicus	247-256
26617662-8	2015	In addition, PIC II treatment increased the phosphorylation of Smad 2 in the lung tissue.	picroside II	13-19	SMAD family member 2	Mus musculus	63-69
24868147-6	2014	Treatment with 10 muM and 100 muM picroside II significantly improved postischemic myocardial function, reduced myocardial infarct size, inhibited apoptosis, increased myocardial NO content, upregulated Bcl-2, downregulated Bax, and increased the phosphorylation of Akt and endothelial NOS, but cardioprotection was not shown in the 1 muM picroside II treatment group and was abrogated by wortmannin and L-N(G)-nitroarginine methyl ester.	picroside II	34-46	BCL2, apoptosis regulator	Rattus norvegicus	203-208
25317155-3	2014	We found that picroside II inhibited cell apoptosis and reduced the expression of neuron-specific enolase, a marker of neuronal damage, in rats after cerebral ischemic injury.	picroside II	14-26	enolase 2	Rattus norvegicus	82-105
24868147-6	2014	Treatment with 10 muM and 100 muM picroside II significantly improved postischemic myocardial function, reduced myocardial infarct size, inhibited apoptosis, increased myocardial NO content, upregulated Bcl-2, downregulated Bax, and increased the phosphorylation of Akt and endothelial NOS, but cardioprotection was not shown in the 1 muM picroside II treatment group and was abrogated by wortmannin and L-N(G)-nitroarginine methyl ester.	picroside II	34-46	BCL2 associated X, apoptosis regulator	Rattus norvegicus	224-227
24868147-6	2014	Treatment with 10 muM and 100 muM picroside II significantly improved postischemic myocardial function, reduced myocardial infarct size, inhibited apoptosis, increased myocardial NO content, upregulated Bcl-2, downregulated Bax, and increased the phosphorylation of Akt and endothelial NOS, but cardioprotection was not shown in the 1 muM picroside II treatment group and was abrogated by wortmannin and L-N(G)-nitroarginine methyl ester.	picroside II	34-46	AKT serine/threonine kinase 1	Rattus norvegicus	266-269
24868147-8	2014	In conclusion, the data reveals that picroside II has a significant protective effect on myocardial ischemia reperfusion injury in a dose-dependent manner, which was mediated by upregulating the phosphoinositide 3-kinase/Akt/endothelial NOS pathway to increase nitric oxide production and regulating the expressions of Bcl-2 and Bax to inhibit apoptosis.	picroside II	37-49	AKT serine/threonine kinase 1	Rattus norvegicus	221-224
24868147-8	2014	In conclusion, the data reveals that picroside II has a significant protective effect on myocardial ischemia reperfusion injury in a dose-dependent manner, which was mediated by upregulating the phosphoinositide 3-kinase/Akt/endothelial NOS pathway to increase nitric oxide production and regulating the expressions of Bcl-2 and Bax to inhibit apoptosis.	picroside II	37-49	BCL2, apoptosis regulator	Rattus norvegicus	319-324
24868147-8	2014	In conclusion, the data reveals that picroside II has a significant protective effect on myocardial ischemia reperfusion injury in a dose-dependent manner, which was mediated by upregulating the phosphoinositide 3-kinase/Akt/endothelial NOS pathway to increase nitric oxide production and regulating the expressions of Bcl-2 and Bax to inhibit apoptosis.	picroside II	37-49	BCL2 associated X, apoptosis regulator	Rattus norvegicus	329-332
24524292-0	2014	The neuroprotective effect of picroside II via regulating the expression of myelin basic protein after cerebral ischemia injury in rats.	picroside II	30-42	myelin basic protein	Rattus norvegicus	76-96
24524292-5	2014	RESULTS: The protective effect of picroside II was presented by increasing the expression of MBP and decreasing demyelination after cerebral ischemic injury.	picroside II	34-46	myelin basic protein	Rattus norvegicus	93-96
21434346-0	2011	[Effect of picroside II on expressions of TLR4 and NFkappaB in rats with cerebral ischemia reperfusion injury].	picroside II	11-23	toll-like receptor 4	Rattus norvegicus	42-46
22753294-0	2013	Supercritical CO2assisted extraction and LC-MS identification of picroside I and picroside II from Picrorhiza kurroa.	picroside II	81-93	complement C2	Homo sapiens	14-17
22489110-6	2012	The results indicated that the optimal compositions of the therapeutic dose and time window of picroside II in treating cerebral ischemic injury were ischemia 1.5 h with 20 mg/kg body weight according to Bederson"s test, 1.0 h with 20 mg/kg body weight according to cerebral infarction volume, 1.5 h with 20 mg/kg body weight according to the expressions of NSE and S-100 respectively.	picroside II	95-107	enolase 2	Rattus norvegicus	358-361
21524190-7	2011	In addition, both mycophenolic acid (substrate of UGT1A9) and emodin (substrate of UGT1A8 and UGT1A10) could inhibit the glucuronidation of Picroside II with the half maximal inhibitory concentration (IC(50)) values of 173.6 and 76.2 muM, respectively.	picroside II	140-152	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	50-56
21524190-7	2011	In addition, both mycophenolic acid (substrate of UGT1A9) and emodin (substrate of UGT1A8 and UGT1A10) could inhibit the glucuronidation of Picroside II with the half maximal inhibitory concentration (IC(50)) values of 173.6 and 76.2 muM, respectively.	picroside II	140-152	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	83-89
21524190-7	2011	In addition, both mycophenolic acid (substrate of UGT1A9) and emodin (substrate of UGT1A8 and UGT1A10) could inhibit the glucuronidation of Picroside II with the half maximal inhibitory concentration (IC(50)) values of 173.6 and 76.2 muM, respectively.	picroside II	140-152	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	94-101
21524190-7	2011	In addition, both mycophenolic acid (substrate of UGT1A9) and emodin (substrate of UGT1A8 and UGT1A10) could inhibit the glucuronidation of Picroside II with the half maximal inhibitory concentration (IC(50)) values of 173.6 and 76.2 muM, respectively.	picroside II	140-152	latexin	Homo sapiens	234-237
21524190-9	2011	The K(m) value of Picroside II glucuronidation was close to that in recombinant human UGT1A10 (K(m) = 58.6 muM, V(max) = 721.4 pmol/min/mg protein).	picroside II	18-30	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	86-93
21524190-9	2011	The K(m) value of Picroside II glucuronidation was close to that in recombinant human UGT1A10 (K(m) = 58.6 muM, V(max) = 721.4 pmol/min/mg protein).	picroside II	18-30	latexin	Homo sapiens	107-110
21434346-9	2011	CONCLUSIONS: Picroside II could down-regulate the expressions of TLR4 and NFkappaB, and inhibit the inflammatory response induced apoptosis in cerebral I/R injured rats.	picroside II	13-25	toll-like receptor 4	Rattus norvegicus	65-69
21151457-1	2010	The aim of this study was to explore the effect of picroside II on neuronal apoptosis and the expression of caspase-3 and poly ADP-ribose polymerase (PARP) following middle cerebral artery occlusion/reperfusion in male Wistar rats.	picroside II	51-63	poly (ADP-ribose) polymerase 1	Rattus norvegicus	150-154
20688035-0	2010	Development of novel lipidated analogs of picroside as vaccine adjuvants: acylated analogs of picroside-II elicit strong Th1 and Th2 response to ovalbumin in mice.	picroside II	94-106	negative elongation factor complex member C/D, Th1l	Mus musculus	121-124
20688035-0	2010	Development of novel lipidated analogs of picroside as vaccine adjuvants: acylated analogs of picroside-II elicit strong Th1 and Th2 response to ovalbumin in mice.	picroside II	94-106	heart and neural crest derivatives expressed 2	Mus musculus	129-132
20688035-1	2010	The acylated analogs of picroside-II were synthesized and tested for immune-adjuvant activity in the presence of weak antigen ovalbumin found to stimulate anti-OVA IgG titer, neutralizing antibody (IgG1 and IgG2a) titer as well as the production of soluble mediators of a Th1 response (IL-2 and IFN-gamma) and Th2 response (IL-4) and proliferation of T lymphocytes sub-sets (CD4/CD8).	picroside II	24-36	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	198-202
20688035-1	2010	The acylated analogs of picroside-II were synthesized and tested for immune-adjuvant activity in the presence of weak antigen ovalbumin found to stimulate anti-OVA IgG titer, neutralizing antibody (IgG1 and IgG2a) titer as well as the production of soluble mediators of a Th1 response (IL-2 and IFN-gamma) and Th2 response (IL-4) and proliferation of T lymphocytes sub-sets (CD4/CD8).	picroside II	24-36	immunoglobulin heavy variable V1-9	Mus musculus	207-212
20688035-1	2010	The acylated analogs of picroside-II were synthesized and tested for immune-adjuvant activity in the presence of weak antigen ovalbumin found to stimulate anti-OVA IgG titer, neutralizing antibody (IgG1 and IgG2a) titer as well as the production of soluble mediators of a Th1 response (IL-2 and IFN-gamma) and Th2 response (IL-4) and proliferation of T lymphocytes sub-sets (CD4/CD8).	picroside II	24-36	negative elongation factor complex member C/D, Th1l	Mus musculus	272-275
20688035-1	2010	The acylated analogs of picroside-II were synthesized and tested for immune-adjuvant activity in the presence of weak antigen ovalbumin found to stimulate anti-OVA IgG titer, neutralizing antibody (IgG1 and IgG2a) titer as well as the production of soluble mediators of a Th1 response (IL-2 and IFN-gamma) and Th2 response (IL-4) and proliferation of T lymphocytes sub-sets (CD4/CD8).	picroside II	24-36	interleukin 2	Mus musculus	286-290
20688035-1	2010	The acylated analogs of picroside-II were synthesized and tested for immune-adjuvant activity in the presence of weak antigen ovalbumin found to stimulate anti-OVA IgG titer, neutralizing antibody (IgG1 and IgG2a) titer as well as the production of soluble mediators of a Th1 response (IL-2 and IFN-gamma) and Th2 response (IL-4) and proliferation of T lymphocytes sub-sets (CD4/CD8).	picroside II	24-36	interferon gamma	Mus musculus	295-304
20688035-1	2010	The acylated analogs of picroside-II were synthesized and tested for immune-adjuvant activity in the presence of weak antigen ovalbumin found to stimulate anti-OVA IgG titer, neutralizing antibody (IgG1 and IgG2a) titer as well as the production of soluble mediators of a Th1 response (IL-2 and IFN-gamma) and Th2 response (IL-4) and proliferation of T lymphocytes sub-sets (CD4/CD8).	picroside II	24-36	heart and neural crest derivatives expressed 2	Mus musculus	310-313
20688035-1	2010	The acylated analogs of picroside-II were synthesized and tested for immune-adjuvant activity in the presence of weak antigen ovalbumin found to stimulate anti-OVA IgG titer, neutralizing antibody (IgG1 and IgG2a) titer as well as the production of soluble mediators of a Th1 response (IL-2 and IFN-gamma) and Th2 response (IL-4) and proliferation of T lymphocytes sub-sets (CD4/CD8).	picroside II	24-36	interleukin 4	Mus musculus	324-328
20688035-1	2010	The acylated analogs of picroside-II were synthesized and tested for immune-adjuvant activity in the presence of weak antigen ovalbumin found to stimulate anti-OVA IgG titer, neutralizing antibody (IgG1 and IgG2a) titer as well as the production of soluble mediators of a Th1 response (IL-2 and IFN-gamma) and Th2 response (IL-4) and proliferation of T lymphocytes sub-sets (CD4/CD8).	picroside II	24-36	CD4 antigen	Mus musculus	375-378
21151457-8	2010	Bederson"s score, infarction volume, and expressions of caspase-3 and PARP, as well as apoptosis in the treatment group were, however, significantly decreased compared to those in the control group indicating that intravenous treatment with picroside II might be beneficial to inhibit neuronal apoptosis and, thus, to improve the neurological function of rats upon cerebral ischemia reperfusion injury.	picroside II	241-253	caspase 3	Rattus norvegicus	56-65
21151457-8	2010	Bederson"s score, infarction volume, and expressions of caspase-3 and PARP, as well as apoptosis in the treatment group were, however, significantly decreased compared to those in the control group indicating that intravenous treatment with picroside II might be beneficial to inhibit neuronal apoptosis and, thus, to improve the neurological function of rats upon cerebral ischemia reperfusion injury.	picroside II	241-253	poly (ADP-ribose) polymerase 1	Rattus norvegicus	70-74
15968718-4	2005	Meanwhile, effects of picroside II on the activity of ATPase and swelling extent of mitochondria in hepatocytes damaged by AP were also evaluated.	picroside II	22-34	dynein, axonemal, heavy chain 8	Mus musculus	54-60
15968718-8	2005	Further, in the study of AP model, picroside II inhibited AP-induced liver toxicity in mice, enhanced the activity of ATPase, improved the swelling extent of mitochondria and helped to maintain a normal balance of energy metabolism.	picroside II	35-47	dynein, axonemal, heavy chain 8	Mus musculus	118-124
15968718-9	2005	CONCLUSION: Picroside II can evidently relieve hepatocyte injuries induced by CCl(4), D-GalN and AP, help scavenge free radicals, protect normal constructions of mitochondria membrane and enhance the activity of ATPase in mitochondria, thereby modulating the balance of liver energy metabolism, which might be part of the mechanisms of hepatoprotective effects of picroside II.	picroside II	12-24	galanin and GMAP prepropeptide	Mus musculus	88-92
15968718-9	2005	CONCLUSION: Picroside II can evidently relieve hepatocyte injuries induced by CCl(4), D-GalN and AP, help scavenge free radicals, protect normal constructions of mitochondria membrane and enhance the activity of ATPase in mitochondria, thereby modulating the balance of liver energy metabolism, which might be part of the mechanisms of hepatoprotective effects of picroside II.	picroside II	12-24	dynein, axonemal, heavy chain 8	Mus musculus	212-218
15916740-7	2005	RESULTS: Picroside II decreased the levels of alanine aminotransferase and aspartate aminotransferase in the serum resulting from acute-liver injured mice induced with D-GalN and LPS; it also reduced the content of MDA, and thus, enhanced the activity of SOD.	picroside II	9-21	galanin and GMAP prepropeptide	Mus musculus	170-174
15916740-7	2005	RESULTS: Picroside II decreased the levels of alanine aminotransferase and aspartate aminotransferase in the serum resulting from acute-liver injured mice induced with D-GalN and LPS; it also reduced the content of MDA, and thus, enhanced the activity of SOD.	picroside II	9-21	toll-like receptor 4	Mus musculus	179-182
15916740-8	2005	Picroside II 10 mg/kg was found to protect hepatocytes against apoptosis in a dose-dependent manner; it up-regulated the expression of bcl-2 genes, thus increased the bcl-2/bax ratio.	picroside II	0-12	B cell leukemia/lymphoma 2	Mus musculus	135-140
15916740-8	2005	Picroside II 10 mg/kg was found to protect hepatocytes against apoptosis in a dose-dependent manner; it up-regulated the expression of bcl-2 genes, thus increased the bcl-2/bax ratio.	picroside II	0-12	B cell leukemia/lymphoma 2	Mus musculus	167-172
15916740-8	2005	Picroside II 10 mg/kg was found to protect hepatocytes against apoptosis in a dose-dependent manner; it up-regulated the expression of bcl-2 genes, thus increased the bcl-2/bax ratio.	picroside II	0-12	BCL2-associated X protein	Mus musculus	173-176
29254285-7	2018	RESULTS: Picroside II pretreatment inhibited FFAs-induced lipid accumulation by attenuating the expression of fatty acid transport protein 5, sterol regulatory element binding protein 1 and stearoyl CoA desaturase.	picroside II	9-21	solute carrier family 27 member 5	Homo sapiens	110-140
15968718-9	2005	CONCLUSION: Picroside II can evidently relieve hepatocyte injuries induced by CCl(4), D-GalN and AP, help scavenge free radicals, protect normal constructions of mitochondria membrane and enhance the activity of ATPase in mitochondria, thereby modulating the balance of liver energy metabolism, which might be part of the mechanisms of hepatoprotective effects of picroside II.	picroside II	364-376	dynein, axonemal, heavy chain 8	Mus musculus	212-218
29254285-7	2018	RESULTS: Picroside II pretreatment inhibited FFAs-induced lipid accumulation by attenuating the expression of fatty acid transport protein 5, sterol regulatory element binding protein 1 and stearoyl CoA desaturase.	picroside II	9-21	sterol regulatory element binding transcription factor 1	Homo sapiens	142-185
29254285-7	2018	RESULTS: Picroside II pretreatment inhibited FFAs-induced lipid accumulation by attenuating the expression of fatty acid transport protein 5, sterol regulatory element binding protein 1 and stearoyl CoA desaturase.	picroside II	9-21	stearoyl-CoA desaturase	Homo sapiens	190-213
34353693-11	2021	An increase in expression of MnSOD, catalase, and higher levels of tGSH and GSH:GSSG ratios underlie the ROS salvaging activity of picroside II.	picroside II	131-143	superoxide dismutase 2	Homo sapiens	29-34
34883483-0	2021	The Protective Effect of Picroside II on Isoflurane-Induced Neuronal Injury in Rats via Downregulating miR-195.	picroside II	25-37	microRNA 195	Rattus norvegicus	103-110
34883483-8	2021	Besides, picroside II suppresses the expression of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and miR-195 in vivo and in vitro.	picroside II	9-21	interleukin 1 alpha	Rattus norvegicus	79-87
34883483-8	2021	Besides, picroside II suppresses the expression of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and miR-195 in vivo and in vitro.	picroside II	9-21	interleukin 6	Rattus norvegicus	89-93
34883483-8	2021	Besides, picroside II suppresses the expression of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and miR-195 in vivo and in vitro.	picroside II	9-21	tumor necrosis factor	Rattus norvegicus	99-108
34883483-8	2021	Besides, picroside II suppresses the expression of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and miR-195 in vivo and in vitro.	picroside II	9-21	microRNA 195	Rattus norvegicus	114-121
34883483-9	2021	Furthermore, overexpression of miR-195 abrogates the effects of picroside II on the expression of pro-inflammatory cytokines.	picroside II	64-76	microRNA 195	Rattus norvegicus	31-38
34883483-12	2021	The protective effect of picroside II may be achieved by downregulating the expression of miR-195 and then inhibiting the inflammatory response.	picroside II	25-37	microRNA 195	Rattus norvegicus	90-97
34368363-0	2021	Picroside II Improves Severe Acute Pancreatitis-Induced Hepatocellular Injury in Rats by Affecting JAK2/STAT3 Phosphorylation Signaling.	picroside II	0-12	Janus kinase 2	Rattus norvegicus	99-103
34368363-0	2021	Picroside II Improves Severe Acute Pancreatitis-Induced Hepatocellular Injury in Rats by Affecting JAK2/STAT3 Phosphorylation Signaling.	picroside II	0-12	signal transducer and activator of transcription 3	Rattus norvegicus	104-109
34368363-7	2021	Picroside II treatment repaired hepatocellular injury by reducing the activities of AMY, ALT, and AST; reducing the levels of MDA, TNF-alpha, IL-1, IL-6, p-JAK2, p-STAT3, BAX, and cleaved caspase 3; and increasing the levels of SOD and IL-10.	picroside II	0-12	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	98-101
34368363-7	2021	Picroside II treatment repaired hepatocellular injury by reducing the activities of AMY, ALT, and AST; reducing the levels of MDA, TNF-alpha, IL-1, IL-6, p-JAK2, p-STAT3, BAX, and cleaved caspase 3; and increasing the levels of SOD and IL-10.	picroside II	0-12	tumor necrosis factor	Rattus norvegicus	131-140
34368363-7	2021	Picroside II treatment repaired hepatocellular injury by reducing the activities of AMY, ALT, and AST; reducing the levels of MDA, TNF-alpha, IL-1, IL-6, p-JAK2, p-STAT3, BAX, and cleaved caspase 3; and increasing the levels of SOD and IL-10.	picroside II	0-12	interleukin 6	Rattus norvegicus	148-152
34368363-7	2021	Picroside II treatment repaired hepatocellular injury by reducing the activities of AMY, ALT, and AST; reducing the levels of MDA, TNF-alpha, IL-1, IL-6, p-JAK2, p-STAT3, BAX, and cleaved caspase 3; and increasing the levels of SOD and IL-10.	picroside II	0-12	Janus kinase 2	Rattus norvegicus	156-160
34368363-7	2021	Picroside II treatment repaired hepatocellular injury by reducing the activities of AMY, ALT, and AST; reducing the levels of MDA, TNF-alpha, IL-1, IL-6, p-JAK2, p-STAT3, BAX, and cleaved caspase 3; and increasing the levels of SOD and IL-10.	picroside II	0-12	signal transducer and activator of transcription 3	Rattus norvegicus	164-169
34368363-7	2021	Picroside II treatment repaired hepatocellular injury by reducing the activities of AMY, ALT, and AST; reducing the levels of MDA, TNF-alpha, IL-1, IL-6, p-JAK2, p-STAT3, BAX, and cleaved caspase 3; and increasing the levels of SOD and IL-10.	picroside II	0-12	BCL2 associated X, apoptosis regulator	Rattus norvegicus	171-174
34368363-7	2021	Picroside II treatment repaired hepatocellular injury by reducing the activities of AMY, ALT, and AST; reducing the levels of MDA, TNF-alpha, IL-1, IL-6, p-JAK2, p-STAT3, BAX, and cleaved caspase 3; and increasing the levels of SOD and IL-10.	picroside II	0-12	interleukin 10	Rattus norvegicus	236-241
34368363-9	2021	Picroside II improved SAP-induced hepatocellular injury and antioxidant and anti-inflammatory properties by affecting JAK2/STAT3 phosphorylation signaling.	picroside II	0-12	Janus kinase 2	Rattus norvegicus	118-122
34368363-9	2021	Picroside II improved SAP-induced hepatocellular injury and antioxidant and anti-inflammatory properties by affecting JAK2/STAT3 phosphorylation signaling.	picroside II	0-12	signal transducer and activator of transcription 3	Rattus norvegicus	123-128
34353693-11	2021	An increase in expression of MnSOD, catalase, and higher levels of tGSH and GSH:GSSG ratios underlie the ROS salvaging activity of picroside II.	picroside II	131-143	catalase	Homo sapiens	36-44