PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
22215673-8	2012	Taken together, these findings suggest that the di-arginine motif within the carboxyl terminus of Cdc42 is necessary for this GTPase to bind at membrane sites containing PIP(2), where it can initiate signaling activities that are essential for the oncogenic transformation of cells.	di-arginine	48-59	cell division cycle 42	Mus musculus	98-103
25142030-0	2015	A di-arginine ER retention signal regulates trafficking of HCN1 channels from the early secretory pathway to the plasma membrane.	di-arginine	2-13	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Homo sapiens	59-63
25142030-4	2015	We found that HCN1 contains an ER localization signal and through a series of deletion constructs, identified the responsible di-arginine ER retention signal.	di-arginine	126-137	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Homo sapiens	14-18
25142030-7	2015	In summary, we report a new mode of regulating HCN1 trafficking: through the use of a di-arginine ER retention signal that monitors processing of the channel in the early secretory pathway.	di-arginine	86-97	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Homo sapiens	47-51
24963046-0	2014	The Arg98Trp mutation in human VKORC1 causing VKCFD2 disrupts a di-arginine-based ER retention motif.	di-arginine	64-75	vitamin K epoxide reductase complex subunit 1	Homo sapiens	31-37
24963046-0	2014	The Arg98Trp mutation in human VKORC1 causing VKCFD2 disrupts a di-arginine-based ER retention motif.	di-arginine	64-75	vitamin K epoxide reductase complex subunit 1	Homo sapiens	46-52
24963046-7	2014	Using a combination of in silico analysis and confocal microscopy, we demonstrate for the first time that VKORC1:p.Arg98Trp disrupts a di-arginine ER retention motif resulting in 20% ER colocalization only.	di-arginine	135-146	vitamin K epoxide reductase complex subunit 1	Homo sapiens	106-112
24638068-4	2014	This is particularly interesting as both p35 and p43 include a di-arginine motif that requires masking by MHCII to allow ER egress.	di-arginine	63-74	interleukin 12A	Homo sapiens	41-44
24638068-4	2014	This is particularly interesting as both p35 and p43 include a di-arginine motif that requires masking by MHCII to allow ER egress.	di-arginine	63-74	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	49-52
22498042-7	2012	Efficient retention of STIM1 in the ER during interphase depends on its lysine-rich domain and a di-arginine ER retention signal.	di-arginine	97-108	stromal interaction molecule 1	Homo sapiens	23-28
22215673-0	2012	C-terminal di-arginine motif of Cdc42 protein is essential for binding to phosphatidylinositol 4,5-bisphosphate-containing membranes and inducing cellular transformation.	di-arginine	11-22	cell division cycle 42	Mus musculus	32-37
22215673-8	2012	Taken together, these findings suggest that the di-arginine motif within the carboxyl terminus of Cdc42 is necessary for this GTPase to bind at membrane sites containing PIP(2), where it can initiate signaling activities that are essential for the oncogenic transformation of cells.	di-arginine	48-59	prolactin induced protein	Mus musculus	170-173
22215673-6	2012	The carboxyl-terminal di-arginine motif (Arg-186 and Arg-187) was shown to play an essential role in the binding of Cdc42 to PIP(2)-containing membranes.	di-arginine	22-33	cell division cycle 42	Mus musculus	116-121
19811453-0	2009	A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4.	di-arginine	2-13	thioredoxin related transmembrane protein 4	Homo sapiens	101-105
22215673-6	2012	The carboxyl-terminal di-arginine motif (Arg-186 and Arg-187) was shown to play an essential role in the binding of Cdc42 to PIP(2)-containing membranes.	di-arginine	22-33	prolactin induced protein	Mus musculus	125-128
21602569-8	2011	In comparison, ablation of the di-arginine sequence, R(553)XR(555) (F508del-KXK-CFTR), modified protease susceptibility of NBD1, NBD2, and the full-length protein.	di-arginine	31-42	CF transmembrane conductance regulator	Homo sapiens	80-84
20634894-2	2010	A mutation of PLN in which one of the di-arginine residues at positions 13 and 14 was deleted led to a severe, early onset dilated cardiomyopathy.	di-arginine	38-49	phospholamban	Homo sapiens	14-17
20634894-5	2010	Our data show that PLN is recycled via the retrograde Golgi to ER membrane traffic pathway involving COP-I vesicles, since co-immunoprecipitation assays determined that COP I interactions are dependent on an intact di-arginine motif as PLN RDelta14 did not co-precipitate with COP I containing vesicles.	di-arginine	215-226	phospholamban	Homo sapiens	19-22
20634894-7	2010	Mutations in the di-arginine motif of the Sigma 1-type opioid receptor, the beta-subunit of the signal recognition particle receptor, and Sterol-O-acyltransferase, three proteins identified in our bioinformatic screen also caused mislocalization of these known ER-resident proteins.	di-arginine	17-28	sigma non-opioid intracellular receptor 1	Homo sapiens	42-70
20634894-8	2010	CONCLUSION: We conclude that PLN is enriched in the ER due to COP I-mediated transport that is dependent on its intact di-arginine motif and that the N-terminal di-arginine motif may act as a general ER retrieval sequence.	di-arginine	119-130	phospholamban	Homo sapiens	29-32
20634894-8	2010	CONCLUSION: We conclude that PLN is enriched in the ER due to COP I-mediated transport that is dependent on its intact di-arginine motif and that the N-terminal di-arginine motif may act as a general ER retrieval sequence.	di-arginine	161-172	phospholamban	Homo sapiens	29-32
21334309-2	2011	All three murine FAM69 proteins (FAM69A, FAM69B, FAM69C) localise to the endoplasmic reticulum (ER) in cultured cells, probably via N-terminal di-arginine motifs.	di-arginine	143-154	divergent protein kinase domain 1A	Mus musculus	33-39
21334309-2	2011	All three murine FAM69 proteins (FAM69A, FAM69B, FAM69C) localise to the endoplasmic reticulum (ER) in cultured cells, probably via N-terminal di-arginine motifs.	di-arginine	143-154	divergent protein kinase domain 1C	Mus musculus	49-55
19811453-6	2009	Instead, the cytoplasmic tail has a conserved di-arginine motif of the RXR type.	di-arginine	46-57	retinoid X receptor alpha	Homo sapiens	71-74
12609988-8	2003	Mutagenesis experiments indicate that ER retention of VIPL involves a RKR di-arginine signal.	di-arginine	74-85	lectin, mannose binding 2 like	Homo sapiens	54-58
10212142-7	1999	The presence of the Sec61 subunits in a post-ER compartment suggests that these proteins can escape the ER and be recycled back, despite the fact that none of them contain any known membrane protein retrieval signals such as cytosolic di-lysine or di-arginine motifs.	di-arginine	248-259	SEC61 translocon subunit alpha 1	Homo sapiens	20-25
15992080-2	1999	A combination of a di-arginine addition to the C-terminal of the insulin B-chain, and a glycine substitution in the A-chain, produce an insulin which is soluble at acid pH, but precipitates in sc.	di-arginine	19-30	insulin	Homo sapiens	136-143
1542111-3	1992	Exchanges in the central di-arginine and in the two aromatic residues interfere with IF assembly of vimentin in vitro: on assembly under standard assembly conditions (160 mM-NaCl) most of the protein is included in dense aggregates, with a variable and minor proportion of IFs, whereas at lower ionic concentrations short and incomplete IF-like structures are formed.	di-arginine	25-36	vimentin	Homo sapiens	100-108
33259547-0	2020	Di-arginine and FFAT-like motifs retain a subpopulation of PRA1 at ER-mitochondria membrane contact sites.	di-arginine	0-11	Rab acceptor 1	Homo sapiens	59-63
33259547-4	2020	We also demonstrate that PRA1 contains two previously unidentified ER retention/retrieval amino acid sequences on its cytosolic N-terminal region: a membrane distal di-arginine motif and a novel membrane proximal FFAT-like motif.	di-arginine	165-176	Rab acceptor 1	Homo sapiens	25-29