PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 21060292-4 2010 Of all the compounds tested, phylligenin and quebrachitol exhibited potent and concentration-dependent inhibitory effects on PAF receptor binding, with IC(50) values of 13.1 and 42.2 microM, respectively. Quebrachitol 45-57 platelet-activating factor receptor Oryctolagus cuniculus 125-137 30486330-0 2018 l-Quebrachitol Promotes the Proliferation, Differentiation, and Mineralization of MC3T3-E1 Cells: Involvement of the BMP-2/Runx2/MAPK/Wnt/beta-Catenin Signaling Pathway. Quebrachitol 0-14 bone morphogenetic protein 2 Mus musculus 117-122 30486330-0 2018 l-Quebrachitol Promotes the Proliferation, Differentiation, and Mineralization of MC3T3-E1 Cells: Involvement of the BMP-2/Runx2/MAPK/Wnt/beta-Catenin Signaling Pathway. Quebrachitol 0-14 runt related transcription factor 2 Mus musculus 123-128 30486330-0 2018 l-Quebrachitol Promotes the Proliferation, Differentiation, and Mineralization of MC3T3-E1 Cells: Involvement of the BMP-2/Runx2/MAPK/Wnt/beta-Catenin Signaling Pathway. Quebrachitol 0-14 catenin (cadherin associated protein), beta 1 Mus musculus 138-150 30486330-8 2018 In addition, l-quebrachitol upregulates the mRNA and protein expression of bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2), while down-regulating the receptor activator of the nuclear factor-kappaB ligand (RANKL) mRNA level. Quebrachitol 13-27 bone morphogenetic protein 2 Mus musculus 75-103 30486330-8 2018 In addition, l-quebrachitol upregulates the mRNA and protein expression of bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2), while down-regulating the receptor activator of the nuclear factor-kappaB ligand (RANKL) mRNA level. Quebrachitol 13-27 bone morphogenetic protein 2 Mus musculus 105-110 30486330-8 2018 In addition, l-quebrachitol upregulates the mRNA and protein expression of bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2), while down-regulating the receptor activator of the nuclear factor-kappaB ligand (RANKL) mRNA level. Quebrachitol 13-27 runt related transcription factor 2 Mus musculus 116-151 30486330-8 2018 In addition, l-quebrachitol upregulates the mRNA and protein expression of bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2), while down-regulating the receptor activator of the nuclear factor-kappaB ligand (RANKL) mRNA level. Quebrachitol 13-27 runt related transcription factor 2 Mus musculus 153-158 30486330-8 2018 In addition, l-quebrachitol upregulates the mRNA and protein expression of bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2), while down-regulating the receptor activator of the nuclear factor-kappaB ligand (RANKL) mRNA level. Quebrachitol 13-27 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 243-248 30486330-10 2018 These findings indicate that l-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/beta-catenin signaling pathway. Quebrachitol 29-43 bone morphogenetic protein 2 Mus musculus 93-98 30486330-10 2018 These findings indicate that l-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/beta-catenin signaling pathway. Quebrachitol 29-43 runt related transcription factor 2 Mus musculus 123-128 30486330-10 2018 These findings indicate that l-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/beta-catenin signaling pathway. Quebrachitol 29-43 catenin (cadherin associated protein), beta 1 Mus musculus 144-156 12553797-1 2003 The synthesis from l-quebrachitol of a series of 3-deoxygenated ether lipid-type phosphatidylinositol (PI) analogues is reported, that selectively block activation of Akt and downstream substrates without affecting activation of the upstream kinase, PDK-1, or other kinases downstream of ras such as MAPK in H157 and H1703 lung cancer cells that have high levels of constitutively active Akt. Quebrachitol 19-33 AKT serine/threonine kinase 1 Homo sapiens 167-170 12553797-1 2003 The synthesis from l-quebrachitol of a series of 3-deoxygenated ether lipid-type phosphatidylinositol (PI) analogues is reported, that selectively block activation of Akt and downstream substrates without affecting activation of the upstream kinase, PDK-1, or other kinases downstream of ras such as MAPK in H157 and H1703 lung cancer cells that have high levels of constitutively active Akt. Quebrachitol 19-33 pyruvate dehydrogenase kinase 1 Homo sapiens 250-255 12553797-1 2003 The synthesis from l-quebrachitol of a series of 3-deoxygenated ether lipid-type phosphatidylinositol (PI) analogues is reported, that selectively block activation of Akt and downstream substrates without affecting activation of the upstream kinase, PDK-1, or other kinases downstream of ras such as MAPK in H157 and H1703 lung cancer cells that have high levels of constitutively active Akt. Quebrachitol 19-33 AKT serine/threonine kinase 1 Homo sapiens 388-391 32502632-5 2020 Besides, QBC treatment significantly reduced the MRSA virulence productions such as lipase and hemolysis. Quebrachitol 9-12 lipase Staphylococcus aureus 84-90