PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33012204-6 2020 Mitochondrial isolevuglandins in arterioles from hypertensive patients were 250% greater than in arterioles from normotensive subjects, and ex vivo mito2HOBA treatment of arterioles from hypertensive subjects increased deacetylation of a key mitochondrial antioxidant, SOD2 (superoxide dismutase 2). mito2hoba 148-157 superoxide dismutase 2 Homo sapiens 269-273 33012204-6 2020 Mitochondrial isolevuglandins in arterioles from hypertensive patients were 250% greater than in arterioles from normotensive subjects, and ex vivo mito2HOBA treatment of arterioles from hypertensive subjects increased deacetylation of a key mitochondrial antioxidant, SOD2 (superoxide dismutase 2). mito2hoba 148-157 superoxide dismutase 2 Homo sapiens 275-297 33012204-7 2020 In human aortic endothelial cells stimulated with Ang II plus TNF (tumor necrosis factor)-alpha, mito2HOBA reduced mitochondrial superoxide and cardiolipin oxidation, a specific marker of mitochondrial oxidative stress. mito2hoba 97-106 tumor necrosis factor Homo sapiens 62-95 33012204-8 2020 In Ang II-infused mice, mito2HOBA diminished mitochondrial isolevuglandins-protein adducts, raised Sirt3 (sirtuin 3) mitochondrial deacetylase activity, reduced vascular superoxide, increased endothelial nitric oxide, improved endothelium-dependent relaxation, and attenuated hypertension. mito2hoba 24-33 angiogenin Homo sapiens 3-6 33012204-8 2020 In Ang II-infused mice, mito2HOBA diminished mitochondrial isolevuglandins-protein adducts, raised Sirt3 (sirtuin 3) mitochondrial deacetylase activity, reduced vascular superoxide, increased endothelial nitric oxide, improved endothelium-dependent relaxation, and attenuated hypertension. mito2hoba 24-33 sirtuin 3 Mus musculus 99-104 33012204-8 2020 In Ang II-infused mice, mito2HOBA diminished mitochondrial isolevuglandins-protein adducts, raised Sirt3 (sirtuin 3) mitochondrial deacetylase activity, reduced vascular superoxide, increased endothelial nitric oxide, improved endothelium-dependent relaxation, and attenuated hypertension. mito2hoba 24-33 sirtuin 3 Mus musculus 106-115 33012204-9 2020 Mito2HOBA preserved mitochondrial respiration, protected ATP production, and reduced mitochondrial permeability pore opening in Ang II-infused mice. mito2hoba 0-9 angiogenin Homo sapiens 128-131