PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
15781442-5	2005	The AOX inhibitor salicylhydroxamic acid (1 mM; SHAM) inhibited 70% of AOX activity in vivo in both water-replete and drought-exposed plants.	salicylhydroxamic acid	18-40	ubiquinol oxidase 1a, mitochondrial	Triticum aestivum	4-7
15781442-5	2005	The AOX inhibitor salicylhydroxamic acid (1 mM; SHAM) inhibited 70% of AOX activity in vivo in both water-replete and drought-exposed plants.	salicylhydroxamic acid	18-40	ubiquinol oxidase 1a, mitochondrial	Triticum aestivum	71-74
15632145-6	2005	However, a stronger inhibition of root growth in KO-AtPrxII F seedlings as compared with wild type is observed under stress conditions induced by CdCl2 as well as after administration of salicylhydroxamic acid, an inhibitor of cyanide-insensitive respiration.	salicylhydroxamic acid	187-209	peroxiredoxin IIF	Arabidopsis thaliana	52-61
16036342-6	2005	The activation of 9 and 13-LOX, using different timing, leads to the formation of LOOH with a subsequent generation of jasmonates and IAA as highlighted by the addition on the potato tuber slices of salicylhydroxamic acid (SHAM), an inhibitor of LOX activity.	salicylhydroxamic acid	199-221	linoleate 9S-lipoxygenase 2	Solanum tuberosum	27-30
16036342-6	2005	The activation of 9 and 13-LOX, using different timing, leads to the formation of LOOH with a subsequent generation of jasmonates and IAA as highlighted by the addition on the potato tuber slices of salicylhydroxamic acid (SHAM), an inhibitor of LOX activity.	salicylhydroxamic acid	199-221	linoleate 9S-lipoxygenase 2	Solanum tuberosum	246-249
12754093-7	2003	In the presence of neutrophils, the A1242-induced luminol chemiluminescence was decreased by the superoxide dismutase inhibitor diethyldithiocarbamic acid (DDC) and the myeloperoxidase inhibitor salicylhydroxamic acid (SHA).	salicylhydroxamic acid	195-217	myeloperoxidase	Homo sapiens	169-184
15763667-1	2005	Plant mitochondria differ from those of mammals, since they incorporate an alternative electron transport pathway, which branches at ubiquinol to an alternative oxidase (AOX), characteristically inhibited by salicylhydroxamic acid (SHAM).	salicylhydroxamic acid	208-230	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	149-168
15763667-1	2005	Plant mitochondria differ from those of mammals, since they incorporate an alternative electron transport pathway, which branches at ubiquinol to an alternative oxidase (AOX), characteristically inhibited by salicylhydroxamic acid (SHAM).	salicylhydroxamic acid	208-230	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	170-173
15236572-0	2004	Crystal structure of the ascorbate peroxidase-salicylhydroxamic acid complex.	salicylhydroxamic acid	46-68	peroxidase	Glycine max	35-45
15236572-6	2004	In this work, the X-ray crystal structure of recombinant soybean cytosolic ascorbate peroxidase (rsAPX) in complex with salicylhydroxamic acid (SHA) has been determined to 1.46 A.	salicylhydroxamic acid	120-142	peroxidase	Glycine max	85-95
12375274-6	2002	SHA inhibited the binding of P- and L-selectin to sulphatide, which is a glycolipid ligand for P- and L-selectin, at a concentration of 1.5 micro g/ml and 100 micro g/ml.	salicylhydroxamic acid	0-3	selectin L	Rattus norvegicus	36-46
12375274-6	2002	SHA inhibited the binding of P- and L-selectin to sulphatide, which is a glycolipid ligand for P- and L-selectin, at a concentration of 1.5 micro g/ml and 100 micro g/ml.	salicylhydroxamic acid	0-3	selectin P	Rattus norvegicus	29-46
11351100-10	2001	Inhibition of the AOX (with salicylhydroxamic acid) decreases respiration rates less than the activity present before inhibition (i.e. measured with the 18O-fractionation technique).	salicylhydroxamic acid	28-50	acyl-CoA oxidase 1	Homo sapiens	18-21
11550050-2	2001	Lipoxygenase inhibitor salicylhydroxamic acid and antioxidants suppressing free radical reactions (ethyl gallate, alpha-tocopherol, astaxanthine, and quercetin) promoted conversion of beta-carotene into retinal catalyzed by beta-carotene-15,15"-dioxygenase.	salicylhydroxamic acid	23-45	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	0-12
10193578-9	1999	The effect of the MPO/H2O2/NaNO2 system was prevented by MPO inhibitors (sodium azide, isoniazid, salicylhydroxamic acid) and also by L-cysteine, L-methionine, L-tryptophan, L-tyrosine, L-histidine and reduced glutathione.	salicylhydroxamic acid	98-120	myeloperoxidase	Equus caballus	18-21
11004581-5	2000	The efficiency of MPO inhibitors to prevent LDL damage increased in the series benzohydroxamic acid < salicylhydroxamic acid < 3-amino-1,2,4-triazole < sodium azide < potassium cyanide < p-hydroxy-benzoic acid hydrazide, while for the HOCl traps the protective efficiency increased in the series glycine < taurine < methionine.	salicylhydroxamic acid	105-127	myeloperoxidase	Homo sapiens	18-21
10925265-10	2000	Interestingly, sHA-induced DC maturation does not involve the HA receptors CD44 or the receptor for hyaluronan-mediated motility, because DC from CD44-deficient mice and wild-type mice both responded similarly to sHA stimulation, whereas the receptor for hyaluronan-mediated motility is not detectable in DC.	salicylhydroxamic acid	15-18	hyaluronan mediated motility receptor (RHAMM)	Mus musculus	242-283
9554960-0	1998	Isolation of mutants of the Arabidopsis thaliana alternative oxidase (ubiquinol:oxygen oxidoreductase) resistant to salicylhydroxamic acid.	salicylhydroxamic acid	116-138	oxidoreductase	Arabidopsis thaliana	87-101
9724695-0	1998	Cyanide restores N gene-mediated resistance to tobacco mosaic virus in transgenic tobacco expressing salicylic acid hydroxylase Salicylhydroxamic acid (SHAM), an inhibitor of alternative oxidase (AOX), blocks salicylic acid-induced resistance to tobacco mosaic virus (TMV) but does not inhibit pathogenesis-related PR-1 protein synthesis or resistance to fungal and bacterial pathogens.	salicylhydroxamic acid	129-151	acyl-CoA oxidase 1	Homo sapiens	197-200
9576176-3	1998	Incubation of HUVEC with humic acid (HA) isolated from the drinking water, as a synthetic humic acid polymer (SHA) or with commercial HA, resulted in a dose-dependent reduction of cell surface thrombomodulin activity.	salicylhydroxamic acid	110-113	thrombomodulin	Homo sapiens	193-207
8619400-1	1996	We have previously shown that humic acid (well-water humic acid, HA, and synthetic humic acid, SHA) enhances cell surface expression of tissue factor (TF).	salicylhydroxamic acid	95-98	coagulation factor III, tissue factor	Canis lupus familiaris	136-149
8718890-0	1996	2.3 A resolution X-ray crystal structure of the bisubstrate analogue inhibitor salicylhydroxamic acid bound to human myeloperoxidase: a model for a prereaction complex with hydrogen peroxide.	salicylhydroxamic acid	79-101	myeloperoxidase	Homo sapiens	117-132
8718890-1	1996	The X-ray crystal structure of a salicylhydroxamic acid (SHA) inhibitory complex with human myeloperoxidase (MPO) has been determined at 2.3 A resolution.	salicylhydroxamic acid	33-55	myeloperoxidase	Homo sapiens	92-107
8718890-1	1996	The X-ray crystal structure of a salicylhydroxamic acid (SHA) inhibitory complex with human myeloperoxidase (MPO) has been determined at 2.3 A resolution.	salicylhydroxamic acid	33-55	myeloperoxidase	Homo sapiens	109-112
8718890-1	1996	The X-ray crystal structure of a salicylhydroxamic acid (SHA) inhibitory complex with human myeloperoxidase (MPO) has been determined at 2.3 A resolution.	salicylhydroxamic acid	57-60	myeloperoxidase	Homo sapiens	92-107
8718890-1	1996	The X-ray crystal structure of a salicylhydroxamic acid (SHA) inhibitory complex with human myeloperoxidase (MPO) has been determined at 2.3 A resolution.	salicylhydroxamic acid	57-60	myeloperoxidase	Homo sapiens	109-112
12226312-3	1996	This led to a large increase in the capacity for AOX respiration, defined as the amount of salicylhydroxamic acid-sensitive O2 uptake by cells in the presence of potassium cyanide.	salicylhydroxamic acid	91-113	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	49-52
8619400-1	1996	We have previously shown that humic acid (well-water humic acid, HA, and synthetic humic acid, SHA) enhances cell surface expression of tissue factor (TF).	salicylhydroxamic acid	95-98	coagulation factor III, tissue factor	Canis lupus familiaris	151-153
8726584-3	1996	The myeloperoxidase (MPO) inhibitor salicylhydroxamic acid (SHA) abrogated luminol but not lucigenin CL in both cell types, but did not further inhibit the already grossly subnormal luminol CL responses seen with MPO-deficient cells which produced normal lucigenin CL.	salicylhydroxamic acid	36-58	myeloperoxidase	Homo sapiens	4-19
8726584-3	1996	The myeloperoxidase (MPO) inhibitor salicylhydroxamic acid (SHA) abrogated luminol but not lucigenin CL in both cell types, but did not further inhibit the already grossly subnormal luminol CL responses seen with MPO-deficient cells which produced normal lucigenin CL.	salicylhydroxamic acid	36-58	myeloperoxidase	Homo sapiens	21-24
8726584-3	1996	The myeloperoxidase (MPO) inhibitor salicylhydroxamic acid (SHA) abrogated luminol but not lucigenin CL in both cell types, but did not further inhibit the already grossly subnormal luminol CL responses seen with MPO-deficient cells which produced normal lucigenin CL.	salicylhydroxamic acid	36-58	myeloperoxidase	Homo sapiens	213-216
8726584-3	1996	The myeloperoxidase (MPO) inhibitor salicylhydroxamic acid (SHA) abrogated luminol but not lucigenin CL in both cell types, but did not further inhibit the already grossly subnormal luminol CL responses seen with MPO-deficient cells which produced normal lucigenin CL.	salicylhydroxamic acid	60-63	myeloperoxidase	Homo sapiens	4-19
8726584-3	1996	The myeloperoxidase (MPO) inhibitor salicylhydroxamic acid (SHA) abrogated luminol but not lucigenin CL in both cell types, but did not further inhibit the already grossly subnormal luminol CL responses seen with MPO-deficient cells which produced normal lucigenin CL.	salicylhydroxamic acid	60-63	myeloperoxidase	Homo sapiens	21-24
8726584-3	1996	The myeloperoxidase (MPO) inhibitor salicylhydroxamic acid (SHA) abrogated luminol but not lucigenin CL in both cell types, but did not further inhibit the already grossly subnormal luminol CL responses seen with MPO-deficient cells which produced normal lucigenin CL.	salicylhydroxamic acid	60-63	myeloperoxidase	Homo sapiens	213-216
12228374-5	1995	From experiments with KCN and salicylhydroxamic acid, it was estimated that the capacity of the cytochrome pathway was at least 100 nmol O2 mg-1 protein min-1 and the capacity of the alternative oxidase was at least 50 nmol O2 mg-1 protein min-1.	salicylhydroxamic acid	30-52	uncharacterized protein	Chlamydomonas reinhardtii	153-158
7622786-5	1995	Salicylhydroxamic acid strongly inhibited succinate requiring reductase and cytochrome c oxidase, but the other two reductases only mildly.	salicylhydroxamic acid	0-22	LOC104968582	Bos taurus	76-88
12228374-5	1995	From experiments with KCN and salicylhydroxamic acid, it was estimated that the capacity of the cytochrome pathway was at least 100 nmol O2 mg-1 protein min-1 and the capacity of the alternative oxidase was at least 50 nmol O2 mg-1 protein min-1.	salicylhydroxamic acid	30-52	uncharacterized protein	Chlamydomonas reinhardtii	240-245
12232424-4	1994	Transgenic cells with increased AOX protein had an increased capacity for cyanide-resistant, salicylhydroxamic acid-sensitive respiration compared to wild-type cells, whereas transgenic cells with decreased AOX protein had a decreased capacity for such respiration.	salicylhydroxamic acid	93-115	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	32-35
1424279-6	1992	Addition of inhibitors to the chemiluminescence system demonstrated that the chemiluminescence response was inhibited by azide and salicylhydroxamic acid and reduced by histidine, suggesting that the chemiluminescence response was due to activation of myeloperoxidase, with generation of singlet oxygen.	salicylhydroxamic acid	131-153	myeloperoxidase	Homo sapiens	252-267
8132563-3	1994	Salicylhydroxamic acid and benzohydroxamic acid complexes of myeloperoxidase showed EPR spectra composed of high spin (g = 6.99, 4.93, and 1.95) and low spin (2.66, 2.22, and 1.81) signals.	salicylhydroxamic acid	0-22	myeloperoxidase	Homo sapiens	61-76
16653144-6	1992	Prior treatment of the discs with abscisic acid, salicylhydroxamic acid, or n-propyl gallate, all of which have been shown to suppress AA induction of the hypersensitive response, inhibited the AA-induced increment in LOX activity.	salicylhydroxamic acid	49-71	probable linoleate 9S-lipoxygenase 5	Solanum tuberosum	218-221
1847381-0	1991	Salicylhydroxamic acid inhibits myeloperoxidase activity.	salicylhydroxamic acid	0-22	myeloperoxidase	Homo sapiens	32-47
1847381-5	1991	Salicylhydroxamic acid serves as a donor to the higher oxidation state of myeloperoxidase and thereby inhibits guaiacol oxidation.	salicylhydroxamic acid	0-22	myeloperoxidase	Homo sapiens	74-89
34707508-14	2021	Metabolic changes on sPIINP and sHA synthesis may be related to energy consumption (sCK, sLDH) and the inflammatory reaction (sCRP) produced.	salicylhydroxamic acid	32-35	SHC adaptor protein 2	Homo sapiens	84-87
34944559-7	2021	Furthermore, sHA modulates the expression of epithelial-to-mesenchymal transition (EMT) markers, such as e-cadherin and snail2/slug.	salicylhydroxamic acid	13-16	cadherin 1	Homo sapiens	105-115
34944559-7	2021	Furthermore, sHA modulates the expression of epithelial-to-mesenchymal transition (EMT) markers, such as e-cadherin and snail2/slug.	salicylhydroxamic acid	13-16	snail family transcriptional repressor 2	Homo sapiens	120-126
34944559-7	2021	Furthermore, sHA modulates the expression of epithelial-to-mesenchymal transition (EMT) markers, such as e-cadherin and snail2/slug.	salicylhydroxamic acid	13-16	snail family transcriptional repressor 2	Homo sapiens	127-131
34944559-8	2021	Additionally, sHA downregulates matrix remodeling enzymes such as the matrix metalloproteinases MT1-MMP, MMP2, and MMP9.	salicylhydroxamic acid	14-17	matrix metallopeptidase 14	Homo sapiens	96-103
34944559-8	2021	Additionally, sHA downregulates matrix remodeling enzymes such as the matrix metalloproteinases MT1-MMP, MMP2, and MMP9.	salicylhydroxamic acid	14-17	matrix metallopeptidase 2	Homo sapiens	105-109
34944559-8	2021	Additionally, sHA downregulates matrix remodeling enzymes such as the matrix metalloproteinases MT1-MMP, MMP2, and MMP9.	salicylhydroxamic acid	14-17	matrix metallopeptidase 9	Homo sapiens	115-119
34745175-10	2021	Octylgallate (OG) and salicylhydroxamic acid (SHAM) are less effective than the other inhibitors against protist and plant AOX.	salicylhydroxamic acid	22-44	alternative oxidase 2	Arabidopsis thaliana	123-126
34681248-0	2021	Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core.	salicylhydroxamic acid	83-86	neuropeptide S receptor 1	Mus musculus	26-49
34249036-2	2021	In this study, the effect of inhibition of AOX with different concentrations of salicylhydroxamic acid (SHAM) on the tobacco root development was investigated.	salicylhydroxamic acid	80-102	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	43-46
34284768-9	2021	SHA alleviated ankle swelling and inhibited the production of cytokines, such as IL-1beta and TNF-alpha.	salicylhydroxamic acid	0-3	interleukin 1 alpha	Mus musculus	81-89
34284768-9	2021	SHA alleviated ankle swelling and inhibited the production of cytokines, such as IL-1beta and TNF-alpha.	salicylhydroxamic acid	0-3	tumor necrosis factor	Mus musculus	94-103
34284768-10	2021	In addition, NLRP3, Caspase-1 and IL-1beta, which are activated by MSU were also suppressed by SHA.	salicylhydroxamic acid	95-98	NLR family, pyrin domain containing 3	Mus musculus	13-18
34284768-10	2021	In addition, NLRP3, Caspase-1 and IL-1beta, which are activated by MSU were also suppressed by SHA.	salicylhydroxamic acid	95-98	caspase 1	Mus musculus	20-29
34284768-10	2021	In addition, NLRP3, Caspase-1 and IL-1beta, which are activated by MSU were also suppressed by SHA.	salicylhydroxamic acid	95-98	interleukin 1 alpha	Mus musculus	34-42
2543361-0	1989	Inhibition of myeloperoxidase by salicylhydroxamic acid.	salicylhydroxamic acid	33-55	myeloperoxidase	Homo sapiens	14-29
35405271-7	2022	We found that highly sulfated sHA derivatives potently inhibited CEMIP hyaluronidase activity.	salicylhydroxamic acid	30-33	cell migration inducing protein, hyaluronan binding	Mus musculus	65-70
35631458-9	2022	A decreased number of DCX-expressing neuroblasts after treatment with escitalopram was augmented by SHA-68 coadministration.	salicylhydroxamic acid	100-103	doublecortin	Rattus norvegicus	22-25
2543361-3	1989	The concentration of salicylhydroxamic acid necessary for complete inhibition of myeloperoxidase activity was 30-50 microM (I50 values of 3-5 microM) compared with the non-specific inhibitor NaN3, which exhibited maximal inhibition at 100-200 microM (I50 values of 30-50 microM).	salicylhydroxamic acid	21-43	myeloperoxidase	Homo sapiens	81-96
2543361-5	1989	Salicylhydroxamic acid prevented the formation of myeloperoxidase Compound II, but only at low H2O2 concentrations, suggesting that it may compete for the H2O2-binding site on the enzyme.	salicylhydroxamic acid	0-22	myeloperoxidase	Homo sapiens	50-65
2543361-6	1989	These data suggest that salicylhydroxamic acid may be used as a potent inhibitor to delineate the function of myeloperoxidase in neutrophil-mediated inflammatory events.	salicylhydroxamic acid	24-46	myeloperoxidase	Homo sapiens	110-125
3570474-3	1987	SHA precoated with 3 X 10(8) DL1 cells bound 75 to 80% of available PK93 cells at all input amounts tested, up to an input of 8 X 10(7) cells.	salicylhydroxamic acid	0-3	Galactose-specific C-type lectin	Drosophila melanogaster	29-32
2559945-0	1989	Role of myeloperoxidase in the killing of Staphylococcus aureus by human neutrophils: studies with the myeloperoxidase inhibitor salicylhydroxamic acid.	salicylhydroxamic acid	129-151	myeloperoxidase	Homo sapiens	103-118
2559945-1	1989	We have used salicylhydroxamic acid (SHAM) to inhibit intraphagosomal myeloperoxidase activity in order to evaluate the role of this enzyme in the killing of Staphylococcus aureus by human neutrophils.	salicylhydroxamic acid	13-35	myeloperoxidase	Homo sapiens	70-85
16664999-4	1986	This peroxidase, which can use both NADH and NADPH as a substrate, is stimulated by low concentrations of monophenols, e.g. salicylhydroxamic acid and 2-methoxyphenol.	salicylhydroxamic acid	124-146	peroxidase 1	Zea mays	5-15
16664999-7	1986	The consequence of the present finding for in vivo respiration measurements is that the use of low concentrations of salicylhydroxamic acid and uncoupler is reliable only in the presence of a suitable superoxide free radical scavenger which prevents activation of the peroxidase.	salicylhydroxamic acid	117-139	peroxidase 1	Zea mays	268-278
3717945-4	1986	Furthermore, a significant reduction of salicylhydroxamic acid and nicotinohydroxamic acid was also observed, when an electron donor of aldehyde oxidase was added, with liver cytosols from hamsters, guinea pigs, rats, and mice.	salicylhydroxamic acid	40-62	aldehyde oxidase 1	Homo sapiens	136-152
3717945-5	1986	The cytosolic reductase activities toward salicylhydroxamic acid were markedly inhibited by menadione, an inhibitor of aldehyde oxidase.	salicylhydroxamic acid	42-64	aldehyde oxidase 1	Homo sapiens	119-135
3086125-2	1986	Lipoxygenase is inhibited by nordihydroguaiaretic acid (NDGA), 3-amino-1-(m-(trifluoromethyl)phenyl)-2-pyrazoline (BW755C), 5,8,11,14-eicosatetraynoic acid (ETYA), salicylhydroxamate (SHAM) or hemin.	salicylhydroxamic acid	164-182	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	0-12
16661720-6	1981	This O(2) consumption was completely inhibited by propyl gallate or salicylhydroxamic acid, two known lipoxygenase inhibitors.	salicylhydroxamic acid	68-90	LOC543232	Triticum aestivum	102-114
3924036-3	1985	The antimycin A-resistant oxygen uptake was further inhibited by the lipoxygenase inhibitors salicylhydroxamic acid, 5,8,11,14-eicosatetraynoic acid, nordihydroguaiaretic acid, 4-nitrocatechol or propylgallate by about 20-30% corresponding to 5-7% of the total oxygen uptake.	salicylhydroxamic acid	93-115	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	69-81
16663862-6	1984	The in vivo lipoxygenase activity of the embryonic axes was estimated by both the fraction of total oxygen uptake that was inhibited by butylated hydroxyanisole and by the fraction of photoemission that was inhibited by butylated hydroxyanisole and by salicylhydroxamic acid.	salicylhydroxamic acid	252-274	linoleate 9S-lipoxygenase-4	Glycine max	12-24
6747294-15	1984	The formation of covalent bonds between IgG and C3 and probably C4 was essential for inhibition of immune precipitation, because inhibitors of their formation, such as putrescine, cadaverine, and salicylhydroxamic acid, effectively prevented the inhibition of precipitation.	salicylhydroxamic acid	196-218	complement C4A (Rodgers blood group)	Homo sapiens	64-66
7315109-3	1981	The proteolysis is inhibited by anaerobiosis and salicylhydroxamic acid which indicates that it is preceded by the attack of lipoxygenase.	salicylhydroxamic acid	49-71	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	125-137
16661259-5	1980	Kinetic analysis indicated that propyl gallate inhibition of the alternative pathway occurred at, or very near, the site of inhibition of the alternative pathway by salicylhydroxamic acid.A high level of lipoxygenase activity was found to be associated with washed mitochondria isolated from a variety of etiolated plant tissues.	salicylhydroxamic acid	165-187	linoleate 9S-lipoxygenase-like	Vigna radiata	204-216
16661461-6	1980	This activity was inhibited either by salicylhydroxamic acid or propyl gallate, a known lipoxygenase inhibitor.	salicylhydroxamic acid	38-60	LOC543232	Triticum aestivum	88-100
16660540-5	1978	Soybean lipoxygenase exhibits similar characteristics of insensitivity to cyanide and sensitivity to salicylhydroxamate and to propyl gallate.	salicylhydroxamic acid	101-119	linoleate 9S-lipoxygenase-4	Glycine max	8-20
30542981-9	2019	Inhibition of the alternative respiration by salicylhydroxamic acid (SHAM) decreased the fresh weight, K+ content, Valt, H+-ATPase activity and the gene expression of AOX1a, HvNHX1, HvNHX3, HvHVP1, HvHVA, H+-ATPase, but increased the electrolyte leakage, MDA and Na+ content in both cultivars under 300 mM NaCl treatment.	salicylhydroxamic acid	45-67	HvNHX1	Hordeum vulgare	174-180
32187792-8	2021	This was paralleled by ShA-induced increases in GluN1, GluN2A, and GluN2B NMDA receptor subunits and their scaffolding protein SAP102 in the ILc homogenate, but not postsynaptic density, of these knockout animals.	salicylhydroxamic acid	23-26	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	48-53
32187792-8	2021	This was paralleled by ShA-induced increases in GluN1, GluN2A, and GluN2B NMDA receptor subunits and their scaffolding protein SAP102 in the ILc homogenate, but not postsynaptic density, of these knockout animals.	salicylhydroxamic acid	23-26	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	55-61
32187792-8	2021	This was paralleled by ShA-induced increases in GluN1, GluN2A, and GluN2B NMDA receptor subunits and their scaffolding protein SAP102 in the ILc homogenate, but not postsynaptic density, of these knockout animals.	salicylhydroxamic acid	23-26	discs large MAGUK scaffold protein 3	Rattus norvegicus	127-133
30144237-6	2019	In response to ShA and LgA cocaine intake, SLC1A2 and Grin1 mRNA levels decreased in SERT+/+ rats to levels equal of those of SERT-/- rats.	salicylhydroxamic acid	15-18	solute carrier family 1 member 2	Rattus norvegicus	43-49
30144237-6	2019	In response to ShA and LgA cocaine intake, SLC1A2 and Grin1 mRNA levels decreased in SERT+/+ rats to levels equal of those of SERT-/- rats.	salicylhydroxamic acid	15-18	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	54-59
30660005-7	2019	Furthermore, molecular modeling and surface plasmon resonance (SPR) analyses demonstrated that sulfation of HA increases binding strength to HB-EGF thus providing a rationale for the development of sHA-containing hydrogels.	salicylhydroxamic acid	198-201	heparin binding EGF like growth factor	Homo sapiens	141-147
30660005-10	2019	Importantly, hydrogels containing sHA strongly increased the effectivity of HB-EGF in inducing epithelial tip growth in epithelial wounds shown in a porcine skin organ culture model.	salicylhydroxamic acid	34-37	heparin binding EGF like growth factor	Homo sapiens	76-82
33628397-2	2021	A previous study showed that Bgl2p and Ecm33p may mediate the interaction between the yeast and saliva-coated hydroxyapatite (SHA; a model for the tooth surface).	salicylhydroxamic acid	126-129	glucan 1,3-beta-glucosidase	Saccharomyces cerevisiae S288C	29-34
33628397-2	2021	A previous study showed that Bgl2p and Ecm33p may mediate the interaction between the yeast and saliva-coated hydroxyapatite (SHA; a model for the tooth surface).	salicylhydroxamic acid	126-129	Ecm33p	Saccharomyces cerevisiae S288C	39-45
33628397-10	2021	Conclusion: Bgl2p and Ecm33p contributed to the interaction between C. albicans and SHA beads.	salicylhydroxamic acid	84-87	glucan 1,3-beta-glucosidase	Saccharomyces cerevisiae S288C	12-17
33628397-10	2021	Conclusion: Bgl2p and Ecm33p contributed to the interaction between C. albicans and SHA beads.	salicylhydroxamic acid	84-87	Ecm33p	Saccharomyces cerevisiae S288C	22-28
31795459-6	2019	However, this mitigating effect was aggravated by salicylhydroxamic acid (SHAM, an AOX inhibitor), suggesting that AP contributes to NO-enhanced Cd stress tolerance.	salicylhydroxamic acid	50-72	acyl-CoA oxidase 1	Homo sapiens	83-86
31795459-6	2019	However, this mitigating effect was aggravated by salicylhydroxamic acid (SHAM, an AOX inhibitor), suggesting that AP contributes to NO-enhanced Cd stress tolerance.	salicylhydroxamic acid	74-78	acyl-CoA oxidase 1	Homo sapiens	83-86
30542981-9	2019	Inhibition of the alternative respiration by salicylhydroxamic acid (SHAM) decreased the fresh weight, K+ content, Valt, H+-ATPase activity and the gene expression of AOX1a, HvNHX1, HvNHX3, HvHVP1, HvHVA, H+-ATPase, but increased the electrolyte leakage, MDA and Na+ content in both cultivars under 300 mM NaCl treatment.	salicylhydroxamic acid	45-67	NHX3	Hordeum vulgare	182-188
30036452-3	2018	The construct comprises an active enzymatic protein core (cytochrome c) self-assembled with cancer cell targeting motifs (somatostatin) through boronic acid/salicylhydroxamate chemistry.	salicylhydroxamic acid	157-175	cytochrome c, somatic	Homo sapiens	58-70
29954869-8	2018	In addition, both the singlet oxygen scavenger His and the lipoxygenase inhibitor salicylhydroxamic acid specifically inhibited singlet oxygen accumulation and cell death.	salicylhydroxamic acid	82-104	lipoxygenase 1	Arabidopsis thaliana	59-71
29783109-7	2018	The IC50 for SHA was 36.63 +- 4.11 microg mL-l. SHA also reduced the levels of COX-2, IL-6, and TNF-alpha, and inhibited certain key molecular mediators of the NF-kappaB and MAPK pathways in keratinocytes.	salicylhydroxamic acid	13-16	cox2	Sargassum horneri	79-84
29783109-7	2018	The IC50 for SHA was 36.63 +- 4.11 microg mL-l. SHA also reduced the levels of COX-2, IL-6, and TNF-alpha, and inhibited certain key molecular mediators of the NF-kappaB and MAPK pathways in keratinocytes.	salicylhydroxamic acid	48-51	cox2	Sargassum horneri	79-84
27610455-3	2016	Sulfated hyaluronan (sHA) and chondroitin sulfate (sCS) derivatives interfered with TIMP-3/LRP-1 complex formation in a sulfation-dependent manner stronger than heparin.	salicylhydroxamic acid	21-24	TIMP metallopeptidase inhibitor 3	Homo sapiens	84-90
29282520-6	2018	Higher concentrations of sHA were found to induce expression of the anti-lymphangiogenic cytokine TGFbeta in LECs, which serves to counter-regulate sHA-induced LEC proliferation and lymphangiogenesis.	salicylhydroxamic acid	25-28	transforming growth factor, beta 1	Mus musculus	98-105
29282520-6	2018	Higher concentrations of sHA were found to induce expression of the anti-lymphangiogenic cytokine TGFbeta in LECs, which serves to counter-regulate sHA-induced LEC proliferation and lymphangiogenesis.	salicylhydroxamic acid	25-28	laryngotracheo esophageal cleft	Mus musculus	109-112
29282520-6	2018	Higher concentrations of sHA were found to induce expression of the anti-lymphangiogenic cytokine TGFbeta in LECs, which serves to counter-regulate sHA-induced LEC proliferation and lymphangiogenesis.	salicylhydroxamic acid	148-151	transforming growth factor, beta 1	Mus musculus	98-105
29282520-6	2018	Higher concentrations of sHA were found to induce expression of the anti-lymphangiogenic cytokine TGFbeta in LECs, which serves to counter-regulate sHA-induced LEC proliferation and lymphangiogenesis.	salicylhydroxamic acid	148-151	laryngotracheo esophageal cleft	Mus musculus	109-112
29282520-7	2018	Using appropriate knockout mice and blocking antibodies, we found that the effects of sHA are mediated by the sialylated form of the lymphatic HA receptor LYVE-1, but not by CD44 or TLR-4.	salicylhydroxamic acid	86-89	lymphatic vessel endothelial hyaluronan receptor 1	Mus musculus	155-161
29122888-7	2017	The AHR response to sHA was evaluated in the isolated tracheal ring assay in tracheal rings from TSG-6-/- or TSG-6+/+, with or without the addition of exogenous TSG-6, and with or without inhibitors of Rho-associated, coiled-coil-containing protein kinase (ROCK), ERK, or PI3K.	salicylhydroxamic acid	20-23	tumor necrosis factor alpha induced protein 6	Mus musculus	97-102
29122888-7	2017	The AHR response to sHA was evaluated in the isolated tracheal ring assay in tracheal rings from TSG-6-/- or TSG-6+/+, with or without the addition of exogenous TSG-6, and with or without inhibitors of Rho-associated, coiled-coil-containing protein kinase (ROCK), ERK, or PI3K.	salicylhydroxamic acid	20-23	tumor necrosis factor alpha induced protein 6	Mus musculus	109-114
29122888-7	2017	The AHR response to sHA was evaluated in the isolated tracheal ring assay in tracheal rings from TSG-6-/- or TSG-6+/+, with or without the addition of exogenous TSG-6, and with or without inhibitors of Rho-associated, coiled-coil-containing protein kinase (ROCK), ERK, or PI3K.	salicylhydroxamic acid	20-23	tumor necrosis factor alpha induced protein 6	Mus musculus	109-114
29122888-10	2017	Moreover, TSG-6-/- tracheal ring non-responsiveness to sHA was reversed by exogenous TSG-6 addition.	salicylhydroxamic acid	55-58	tumor necrosis factor alpha induced protein 6	Mus musculus	10-15
29122888-10	2017	Moreover, TSG-6-/- tracheal ring non-responsiveness to sHA was reversed by exogenous TSG-6 addition.	salicylhydroxamic acid	55-58	tumor necrosis factor alpha induced protein 6	Mus musculus	85-90
27610455-3	2016	Sulfated hyaluronan (sHA) and chondroitin sulfate (sCS) derivatives interfered with TIMP-3/LRP-1 complex formation in a sulfation-dependent manner stronger than heparin.	salicylhydroxamic acid	21-24	LDL receptor related protein 1	Homo sapiens	91-96
27610455-5	2016	In vitro studies revealed increased amounts of pericellular TIMP-3 in the presence of sHA as a consequence of the blocked protein uptake.	salicylhydroxamic acid	86-89	TIMP metallopeptidase inhibitor 3	Homo sapiens	60-66
22963672-5	2013	The reduced stomatal apertures of siz1 were inhibited by the application of peroxidase inhibitors, salicylhydroxamic acid and azide, which inhibits SA-dependent reactive oxygen species (ROS) production, but not by an NADPH oxidase inhibitor, diphenyl iodonium chloride, which inhibits ABA-dependent ROS production.	salicylhydroxamic acid	99-121	DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein	Arabidopsis thaliana	34-38
26891589-5	2016	Use of the enzyme inhibitors salicylhydroxamic acid (SHAM) or diphenyleneiodonium chloride (DPI) suggest that peroxidase and, to a lesser extent, NADPH oxidase were required to prevent or reduce injury in all low pH treatments.	salicylhydroxamic acid	29-51	peroxidase	Solanum lycopersicum	110-120
27239435-2	2016	The AOX1a transformant (pYES2AtAOX1a) showed cyanide resistant and salicylhydroxamic acid (SHAM)-sensitive respiration, indicating functional expression of AtAOX1a in S. cerevisiae.	salicylhydroxamic acid	67-89	alternative oxidase 1A	Arabidopsis thaliana	4-9
27239435-2	2016	The AOX1a transformant (pYES2AtAOX1a) showed cyanide resistant and salicylhydroxamic acid (SHAM)-sensitive respiration, indicating functional expression of AtAOX1a in S. cerevisiae.	salicylhydroxamic acid	67-89	alternative oxidase 1A	Arabidopsis thaliana	29-36
27497090-4	2016	In the present study, pretreatment of seedlings with Salicylhydroxamic acid, an inhibitor of lipoxigenase (LOX) in JA biosynthesis, significantly suppressed RIBE-mediated expression of the AtRAD54 gene.	salicylhydroxamic acid	53-75	DNA repair/recombination protein	Arabidopsis thaliana	189-196
26617622-6	2015	Importantly, the application of the salicylhydroxamic acid (SHAM, AOX inhibitor) and ethylene biosynthesis inhibitor aminooxyacetic acid (AOA) decreased plant resistance to environmental stress by blocking BRs-induced alternative respiration.	salicylhydroxamic acid	36-58	ubiquinol oxidase 4, chloroplastic/chromoplastic	Cucumis sativus	66-69
23649227-10	2013	This finding is in contrast to the effect of salicylhydroxamic acid, another well-known inhibitor of AOX, which also increased the number of dying cells while it increased the ROS production.	salicylhydroxamic acid	45-67	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	101-104
24194519-3	2013	Previously, salicylhydroxamic acid was reported to be a weak reversible inhibitor of MPO.	salicylhydroxamic acid	12-34	myeloperoxidase	Homo sapiens	85-88
22963672-5	2013	The reduced stomatal apertures of siz1 were inhibited by the application of peroxidase inhibitors, salicylhydroxamic acid and azide, which inhibits SA-dependent reactive oxygen species (ROS) production, but not by an NADPH oxidase inhibitor, diphenyl iodonium chloride, which inhibits ABA-dependent ROS production.	salicylhydroxamic acid	99-121	peroxidase	Arabidopsis thaliana	76-86
22429403-4	2012	The inhibition of the AOX pathway by salicylhydroxamic acid (SHAM) caused the over-reduction of the photosystem I (PSI) acceptor side, as indicated by the increases in the extent of reduction of P700+.	salicylhydroxamic acid	37-59	acyl-CoA oxidase 1	Homo sapiens	22-25
23086900-0	2012	A synthetic polypeptide conjugate from a 42-residue polypeptide and salicylhydroxamic acid binds human myeloperoxidase with high affinity.	salicylhydroxamic acid	68-90	myeloperoxidase	Homo sapiens	103-118
23086900-3	2012	To develop a molecule that binds MPO, salicylhydroxamic acid (SHA), a substrate analog inhibitor of MPO with a KD=2 muM, was conjugated to a designed set of 42-residue polypeptide scaffolds via 9- and 11-carbon atom aliphatic spacers to form 20 different protein binder candidates, and their interactions with MPO were evaluated by surface plasmon resonance analysis.	salicylhydroxamic acid	38-60	myeloperoxidase	Homo sapiens	33-36
23086900-3	2012	To develop a molecule that binds MPO, salicylhydroxamic acid (SHA), a substrate analog inhibitor of MPO with a KD=2 muM, was conjugated to a designed set of 42-residue polypeptide scaffolds via 9- and 11-carbon atom aliphatic spacers to form 20 different protein binder candidates, and their interactions with MPO were evaluated by surface plasmon resonance analysis.	salicylhydroxamic acid	38-60	myeloperoxidase	Homo sapiens	100-103
23086900-3	2012	To develop a molecule that binds MPO, salicylhydroxamic acid (SHA), a substrate analog inhibitor of MPO with a KD=2 muM, was conjugated to a designed set of 42-residue polypeptide scaffolds via 9- and 11-carbon atom aliphatic spacers to form 20 different protein binder candidates, and their interactions with MPO were evaluated by surface plasmon resonance analysis.	salicylhydroxamic acid	38-60	myeloperoxidase	Homo sapiens	100-103
23086900-3	2012	To develop a molecule that binds MPO, salicylhydroxamic acid (SHA), a substrate analog inhibitor of MPO with a KD=2 muM, was conjugated to a designed set of 42-residue polypeptide scaffolds via 9- and 11-carbon atom aliphatic spacers to form 20 different protein binder candidates, and their interactions with MPO were evaluated by surface plasmon resonance analysis.	salicylhydroxamic acid	62-65	myeloperoxidase	Homo sapiens	33-36
23086900-3	2012	To develop a molecule that binds MPO, salicylhydroxamic acid (SHA), a substrate analog inhibitor of MPO with a KD=2 muM, was conjugated to a designed set of 42-residue polypeptide scaffolds via 9- and 11-carbon atom aliphatic spacers to form 20 different protein binder candidates, and their interactions with MPO were evaluated by surface plasmon resonance analysis.	salicylhydroxamic acid	62-65	myeloperoxidase	Homo sapiens	100-103
23086900-3	2012	To develop a molecule that binds MPO, salicylhydroxamic acid (SHA), a substrate analog inhibitor of MPO with a KD=2 muM, was conjugated to a designed set of 42-residue polypeptide scaffolds via 9- and 11-carbon atom aliphatic spacers to form 20 different protein binder candidates, and their interactions with MPO were evaluated by surface plasmon resonance analysis.	salicylhydroxamic acid	62-65	myeloperoxidase	Homo sapiens	100-103
23180292-4	2012	Treatment with a peroxidase inhibitor, salicylhydroxamic acid (SHAM), led to the reduction of cold resistance in bri1-9.	salicylhydroxamic acid	39-61	peroxidase	Arabidopsis thaliana	17-27
23180292-4	2012	Treatment with a peroxidase inhibitor, salicylhydroxamic acid (SHAM), led to the reduction of cold resistance in bri1-9.	salicylhydroxamic acid	39-61	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	113-119
22554042-5	2012	Importantly, the addition of the AOX inhibitor salicylhydroxamic acid (1 mm; SHAM) decreased plant resistance to environmental stress and even compromised the cyanide (CN)-enhanced stress tolerance.	salicylhydroxamic acid	47-69	ubiquinol oxidase 4, chloroplastic/chromoplastic	Cucumis sativus	33-36
23101394-3	2012	This effect is partially suppressed by both alpha-naphthol (the NADPH oxidase inhibitor) and salicylhydroxamic acid (peroxidase inhibitor).	salicylhydroxamic acid	93-115	peroxidase-like	Triticum aestivum	117-127
22437147-5	2012	The MG-induced stomatal closure and ROS production were completely inhibited by a peroxidase inhibitor, salicylhydroxamic acid (SHAM), but were not affected by an NAD(P)H oxidase mutation, atrbohD atrbohF.	salicylhydroxamic acid	104-126	peroxidase	Arabidopsis thaliana	82-92
19915640-3	2009	Specific MPO inhibitors, salicylhydroxamic acid or (4-aminobenzoyl)hydrazide, are added to measure the activity of other heme-containing peroxidases (mainly hemoglobin and its derivatives) and subtract their contribution from the total plasma peroxidase activity.	salicylhydroxamic acid	25-47	myeloperoxidase	Homo sapiens	9-12
21555367-6	2011	sHA inhibited Akt signaling including androgen receptor (AR) phosphorylation, AR activity, nuclear factor kappaB (NFkappaB) activation, and VEGF expression.	salicylhydroxamic acid	0-3	AKT serine/threonine kinase 1	Homo sapiens	14-17
21555367-6	2011	sHA inhibited Akt signaling including androgen receptor (AR) phosphorylation, AR activity, nuclear factor kappaB (NFkappaB) activation, and VEGF expression.	salicylhydroxamic acid	0-3	androgen receptor	Homo sapiens	38-55
21555367-6	2011	sHA inhibited Akt signaling including androgen receptor (AR) phosphorylation, AR activity, nuclear factor kappaB (NFkappaB) activation, and VEGF expression.	salicylhydroxamic acid	0-3	androgen receptor	Homo sapiens	57-59
21555367-6	2011	sHA inhibited Akt signaling including androgen receptor (AR) phosphorylation, AR activity, nuclear factor kappaB (NFkappaB) activation, and VEGF expression.	salicylhydroxamic acid	0-3	androgen receptor	Homo sapiens	78-80
21555367-6	2011	sHA inhibited Akt signaling including androgen receptor (AR) phosphorylation, AR activity, nuclear factor kappaB (NFkappaB) activation, and VEGF expression.	salicylhydroxamic acid	0-3	nuclear factor kappa B subunit 1	Homo sapiens	91-112
21555367-6	2011	sHA inhibited Akt signaling including androgen receptor (AR) phosphorylation, AR activity, nuclear factor kappaB (NFkappaB) activation, and VEGF expression.	salicylhydroxamic acid	0-3	nuclear factor kappa B subunit 1	Homo sapiens	114-122
21555367-6	2011	sHA inhibited Akt signaling including androgen receptor (AR) phosphorylation, AR activity, nuclear factor kappaB (NFkappaB) activation, and VEGF expression.	salicylhydroxamic acid	0-3	vascular endothelial growth factor A	Homo sapiens	140-144
21555367-8	2011	Angiogenic HA fragments or overexpression of myristoylated Akt or HA receptors blunted these effects of sHA, implicating a feedback loop between HA receptors and PI3K/Akt signaling in the mechanism of action.	salicylhydroxamic acid	104-107	AKT serine/threonine kinase 1	Homo sapiens	59-62
21555367-8	2011	Angiogenic HA fragments or overexpression of myristoylated Akt or HA receptors blunted these effects of sHA, implicating a feedback loop between HA receptors and PI3K/Akt signaling in the mechanism of action.	salicylhydroxamic acid	104-107	AKT serine/threonine kinase 1	Homo sapiens	167-170
27467160-5	2011	A pharmacophore model was developed based on the crystal structure of human MPO in complex with salicylhydroxamic acid (SHA), a known inhibitor of the enzyme.	salicylhydroxamic acid	96-118	myeloperoxidase	Homo sapiens	76-79
27467160-5	2011	A pharmacophore model was developed based on the crystal structure of human MPO in complex with salicylhydroxamic acid (SHA), a known inhibitor of the enzyme.	salicylhydroxamic acid	120-123	myeloperoxidase	Homo sapiens	76-79
20876608-4	2010	A peroxidase inhibitor [salicylhydroxamic acid (SHAM)] inhibited the stomatal closure and the ROS accumulation, but neither the atrbohD atrbohF mutation nor an NADPH oxidase inhibitor [diphenylene iodonium chloride (DPI)] had any effect.	salicylhydroxamic acid	24-46	peroxidase	Arabidopsis thaliana	2-12
20059739-6	2010	Upon restriction of AOX pathway using salicylhydroxamic acid (SHAM), the observed decrease in NaHCO(3)-dependent O(2) evolution or p-benzoquinone (BQ)-dependent O(2) evolution [indicator of photosystem II (PSII) activity] and the increase in total cellular levels of pyruvate and malate were further aggravated/promoted under HL.	salicylhydroxamic acid	38-60	acyl-CoA oxidase 1	Homo sapiens	20-23
19958137-5	2010	Salicylhydroxamic acid (SHAM, an AOX inhibitor) pretreatment reduced the DEA/NO-induced cyanide-resistant respiration and partially compromised induced resistance to TMV.	salicylhydroxamic acid	0-22	acyl-CoA oxidase 1	Homo sapiens	33-36
21779957-3	2012	Pretreatment with potassium cyanide (KCN, a cytochrome pathway inhibitor) greatly increased CN-resistant R and reduced reactive oxygen species (ROS) formation, while application of salicylhydroxamic acid (SHAM, an AOX inhibitor) blocked the AOX activity and enhanced the production of ROS in the plants.	salicylhydroxamic acid	181-203	acyl-CoA oxidase 1	Homo sapiens	241-244
21875751-3	2011	The pH-responsive synthetic mucin-like polymer is constructed with phenylboronic acid (PBA) and salicylhydroxamic acid (SHA), each individually copolymerized with a 2-hydroxypropyl methacrylamide (pHPMA) polymer backbone.	salicylhydroxamic acid	96-118	LOC100508689	Homo sapiens	28-33
21875751-3	2011	The pH-responsive synthetic mucin-like polymer is constructed with phenylboronic acid (PBA) and salicylhydroxamic acid (SHA), each individually copolymerized with a 2-hydroxypropyl methacrylamide (pHPMA) polymer backbone.	salicylhydroxamic acid	120-123	LOC100508689	Homo sapiens	28-33
22276431-3	2011	This increase was partially suppressed by treatment of coleoptiles with inhibitors of peroxidase (salicylhydroxamic acid) and NADP H-oxidase (imidazole and alpha-naphthol).	salicylhydroxamic acid	98-120	peroxidase-like	Triticum aestivum	86-96
21280568-2	2010	About half of the total O2 consumption in such mitochondria was found to be sensitive to salicylhydroxamate (SHAM), a known inhibitor of AOX activity.	salicylhydroxamic acid	89-107	ubiquinol oxidase 1, mitochondrial-like	Solanum tuberosum	137-140
19847118-4	2009	In our previous paper we have demonstrated yet another form of oxidative NO formation, whereby hydroxylamine (HA), but also the AOX-inhibitor salicylhydroxamate (SHAM) is oxidized to NO by tobacco suspension cells.	salicylhydroxamic acid	142-160	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	128-131
16763664-1	2006	We recently reported a novel coupling strategy involving salicylhydroxamic acid and phenyl(di)boronic acid molecules to attach the CNGRC peptide to PEI/DNA for CD13 targeting in tumors.	salicylhydroxamic acid	57-79	alanyl aminopeptidase, membrane	Homo sapiens	160-164
19465478-0	2009	Binding modes of aromatic ligands to mammalian heme peroxidases with associated functional implications: crystal structures of lactoperoxidase complexes with acetylsalicylic acid, salicylhydroxamic acid, and benzylhydroxamic acid.	salicylhydroxamic acid	180-202	lactoperoxidase	Homo sapiens	127-142
19302970-4	2009	Here, we showed that ROS was significantly generated during cotton fiber initiation and elongation, whereas, application of NADPH oxidase inhibitor diphenyleneiodonium (DPI) and peroxidase inhibitor salicylhydroxamic acid (SHAM) to the wild-type cotton ovule culture significantly suppressed fiber growth, respectively.	salicylhydroxamic acid	199-221	peroxidase 13-like	Gossypium hirsutum	178-188
19010505-8	2009	Splenocytes from mice immunized with sHA-mC3d3 produced about three-fold more IL-4 than did splenocytes from mice immunized with sHA or tmHA.	salicylhydroxamic acid	37-40	interleukin 4	Mus musculus	78-82
19357430-3	2009	Here it is shown that tobacco cell suspensions emitted NO when hydroxylamine (HA) or salicylhydroxamate (SHAM), a frequently used AOX inhibitor, was added.	salicylhydroxamic acid	85-103	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	130-133
18031543-5	2008	Furthermore, we also found that sHA treatment enhanced the motility of melanoma cells, an effect that could again be blocked by TLR4-specific siRNA.	salicylhydroxamic acid	32-35	toll like receptor 4	Homo sapiens	128-132
18031543-6	2008	Together, our results suggest that sHA in melanoma might promote tumor invasiveness by inducing MMP- and cytokine-expression, in part in a TLR4-dependent manner, providing new insights into the relationship between cancer and innate immunity.	salicylhydroxamic acid	35-38	matrix metallopeptidase 2	Homo sapiens	96-99
18031543-6	2008	Together, our results suggest that sHA in melanoma might promote tumor invasiveness by inducing MMP- and cytokine-expression, in part in a TLR4-dependent manner, providing new insights into the relationship between cancer and innate immunity.	salicylhydroxamic acid	35-38	toll like receptor 4	Homo sapiens	139-143
17660693-1	2007	Mitochondrial alternative oxidase (AOX) is the terminal oxidase responsible for cyanide-insensitive and salicylhydroxamic acid-sensitive respiration in plants.	salicylhydroxamic acid	104-126	ubiquinol oxidase 1a, mitochondrial	Triticum aestivum	14-33
17660693-1	2007	Mitochondrial alternative oxidase (AOX) is the terminal oxidase responsible for cyanide-insensitive and salicylhydroxamic acid-sensitive respiration in plants.	salicylhydroxamic acid	104-126	ubiquinol oxidase 1a, mitochondrial	Triticum aestivum	35-38
16531464-7	2006	Furthermore, the JA biosynthesis inhibitors ibuprofen and salicylhydroxamic acid (SHAM) suppressed 1-aminocyclopropane-1-carboxylic acid (ACC)-induced root hair formation, and decreased the root hairs in seedlings of the ethylene over-producing mutant eto1-1.	salicylhydroxamic acid	58-80	tetratricopeptide repeat (TPR)-containing protein	Arabidopsis thaliana	252-258
16713147-2	2006	We coupled polyethylene glycol-J591 (PEGylated J591) to a salicyl hydroxamic acid (SHA)-derivatized polyethylenimine (PEI)/DNA-betagal vector to investigate the specificity and efficiency of targeting PSMA in PCA cells through encapsulation.	salicylhydroxamic acid	83-86	folate hydrolase 1	Homo sapiens	201-205
16536622-2	2006	The PPO inhibitors tropolone and salicylhydroxamic acid (each at 1 microM) reduced kernel PPO activity by approximately 50% in three hexaploid wheat cultivars but did not inhibit PPO activity in the two very low PPO cultivars, durum Langdon, and the synthetic hexaploid-derived ID580.	salicylhydroxamic acid	33-55	polyphenol oxidase I, chloroplastic	Triticum aestivum	4-7
16536622-2	2006	The PPO inhibitors tropolone and salicylhydroxamic acid (each at 1 microM) reduced kernel PPO activity by approximately 50% in three hexaploid wheat cultivars but did not inhibit PPO activity in the two very low PPO cultivars, durum Langdon, and the synthetic hexaploid-derived ID580.	salicylhydroxamic acid	33-55	polyphenol oxidase I, chloroplastic	Triticum aestivum	90-93
16536622-2	2006	The PPO inhibitors tropolone and salicylhydroxamic acid (each at 1 microM) reduced kernel PPO activity by approximately 50% in three hexaploid wheat cultivars but did not inhibit PPO activity in the two very low PPO cultivars, durum Langdon, and the synthetic hexaploid-derived ID580.	salicylhydroxamic acid	33-55	polyphenol oxidase I, chloroplastic	Triticum aestivum	90-93
16536622-2	2006	The PPO inhibitors tropolone and salicylhydroxamic acid (each at 1 microM) reduced kernel PPO activity by approximately 50% in three hexaploid wheat cultivars but did not inhibit PPO activity in the two very low PPO cultivars, durum Langdon, and the synthetic hexaploid-derived ID580.	salicylhydroxamic acid	33-55	polyphenol oxidase I, chloroplastic	Triticum aestivum	90-93