PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33222203-3 2020 Recent results on the co-crystal structure of ABCB1 with the flame-retardant BDE-100 demonstrate that a diverse range of man-made and natural toxic molecules, hereafter termed Transporter-Interfering Chemicals (TICs), can directly bind to SMTs and interfere with their function. pentabrominated diphenyl ether 100 77-84 ATP binding cassette subfamily B member 1 Homo sapiens 46-51 27198750-4 2016 In this study, the potencies of 4 different PBDEs (BDE-3, BDE-47, BDE-100, and BDE-153) with 1-6 bromine atoms attached in inhibition of rat and human HSD11B1 and HSD11B2 activities were compared to 4-bromobiphenyl (BBP), a structurally similar compound. pentabrominated diphenyl ether 100 66-73 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 151-158 30796839-9 2019 BDE-100 could act as (1) an agonist of aryl hydrocarbon receptor (AhR), inducing expression of CYP1A1 and CYP1B1 and (2) as a very weak agonist/antagonist of ERalpha. pentabrominated diphenyl ether 100 0-7 aryl hydrocarbon receptor Homo sapiens 39-64 30796839-9 2019 BDE-100 could act as (1) an agonist of aryl hydrocarbon receptor (AhR), inducing expression of CYP1A1 and CYP1B1 and (2) as a very weak agonist/antagonist of ERalpha. pentabrominated diphenyl ether 100 0-7 aryl hydrocarbon receptor Homo sapiens 66-69 30796839-9 2019 BDE-100 could act as (1) an agonist of aryl hydrocarbon receptor (AhR), inducing expression of CYP1A1 and CYP1B1 and (2) as a very weak agonist/antagonist of ERalpha. pentabrominated diphenyl ether 100 0-7 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 95-101 30796839-9 2019 BDE-100 could act as (1) an agonist of aryl hydrocarbon receptor (AhR), inducing expression of CYP1A1 and CYP1B1 and (2) as a very weak agonist/antagonist of ERalpha. pentabrominated diphenyl ether 100 0-7 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 106-112 30796839-9 2019 BDE-100 could act as (1) an agonist of aryl hydrocarbon receptor (AhR), inducing expression of CYP1A1 and CYP1B1 and (2) as a very weak agonist/antagonist of ERalpha. pentabrominated diphenyl ether 100 0-7 estrogen receptor 1 Homo sapiens 158-165 28235828-6 2017 Fetal genetic loci contributed to the levels of BDE-100 (P = 4.6 x 10-8) and PCB187 (P = 2.8 x 10-8), near the potential metabolic genes LOXHD1 and PTPRD, previously implicated in neurodevelopment. pentabrominated diphenyl ether 100 48-55 lipoxygenase homology PLAT domains 1 Homo sapiens 137-143 28235828-6 2017 Fetal genetic loci contributed to the levels of BDE-100 (P = 4.6 x 10-8) and PCB187 (P = 2.8 x 10-8), near the potential metabolic genes LOXHD1 and PTPRD, previously implicated in neurodevelopment. pentabrominated diphenyl ether 100 48-55 protein tyrosine phosphatase receptor type D Homo sapiens 148-153 27198750-4 2016 In this study, the potencies of 4 different PBDEs (BDE-3, BDE-47, BDE-100, and BDE-153) with 1-6 bromine atoms attached in inhibition of rat and human HSD11B1 and HSD11B2 activities were compared to 4-bromobiphenyl (BBP), a structurally similar compound. pentabrominated diphenyl ether 100 66-73 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 163-170 21871953-8 2011 However, in the case of BDE-47 due to activation of 17 beta-HSD and BDE-100 due to activation of CYP17, a corresponding failure to activate CYP19 expression and inhibition of CYP19 activity was seen. pentabrominated diphenyl ether 100 68-75 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 97-102