PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33222203-3	2020	Recent results on the co-crystal structure of ABCB1 with the flame-retardant BDE-100 demonstrate that a diverse range of man-made and natural toxic molecules, hereafter termed Transporter-Interfering Chemicals (TICs), can directly bind to SMTs and interfere with their function.	pentabrominated diphenyl ether 100	77-84	ATP binding cassette subfamily B member 1	Homo sapiens	46-51
27198750-4	2016	In this study, the potencies of 4 different PBDEs (BDE-3, BDE-47, BDE-100, and BDE-153) with 1-6 bromine atoms attached in inhibition of rat and human HSD11B1 and HSD11B2 activities were compared to 4-bromobiphenyl (BBP), a structurally similar compound.	pentabrominated diphenyl ether 100	66-73	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	151-158
30796839-9	2019	BDE-100 could act as (1) an agonist of aryl hydrocarbon receptor (AhR), inducing expression of CYP1A1 and CYP1B1 and (2) as a very weak agonist/antagonist of ERalpha.	pentabrominated diphenyl ether 100	0-7	aryl hydrocarbon receptor	Homo sapiens	39-64
30796839-9	2019	BDE-100 could act as (1) an agonist of aryl hydrocarbon receptor (AhR), inducing expression of CYP1A1 and CYP1B1 and (2) as a very weak agonist/antagonist of ERalpha.	pentabrominated diphenyl ether 100	0-7	aryl hydrocarbon receptor	Homo sapiens	66-69
30796839-9	2019	BDE-100 could act as (1) an agonist of aryl hydrocarbon receptor (AhR), inducing expression of CYP1A1 and CYP1B1 and (2) as a very weak agonist/antagonist of ERalpha.	pentabrominated diphenyl ether 100	0-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	95-101
30796839-9	2019	BDE-100 could act as (1) an agonist of aryl hydrocarbon receptor (AhR), inducing expression of CYP1A1 and CYP1B1 and (2) as a very weak agonist/antagonist of ERalpha.	pentabrominated diphenyl ether 100	0-7	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	106-112
30796839-9	2019	BDE-100 could act as (1) an agonist of aryl hydrocarbon receptor (AhR), inducing expression of CYP1A1 and CYP1B1 and (2) as a very weak agonist/antagonist of ERalpha.	pentabrominated diphenyl ether 100	0-7	estrogen receptor 1	Homo sapiens	158-165
28235828-6	2017	Fetal genetic loci contributed to the levels of BDE-100 (P = 4.6 x 10-8) and PCB187 (P = 2.8 x 10-8), near the potential metabolic genes LOXHD1 and PTPRD, previously implicated in neurodevelopment.	pentabrominated diphenyl ether 100	48-55	lipoxygenase homology PLAT domains 1	Homo sapiens	137-143
28235828-6	2017	Fetal genetic loci contributed to the levels of BDE-100 (P = 4.6 x 10-8) and PCB187 (P = 2.8 x 10-8), near the potential metabolic genes LOXHD1 and PTPRD, previously implicated in neurodevelopment.	pentabrominated diphenyl ether 100	48-55	protein tyrosine phosphatase receptor type D	Homo sapiens	148-153
27198750-4	2016	In this study, the potencies of 4 different PBDEs (BDE-3, BDE-47, BDE-100, and BDE-153) with 1-6 bromine atoms attached in inhibition of rat and human HSD11B1 and HSD11B2 activities were compared to 4-bromobiphenyl (BBP), a structurally similar compound.	pentabrominated diphenyl ether 100	66-73	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	163-170
21871953-8	2011	However, in the case of BDE-47 due to activation of 17 beta-HSD and BDE-100 due to activation of CYP17, a corresponding failure to activate CYP19 expression and inhibition of CYP19 activity was seen.	pentabrominated diphenyl ether 100	68-75	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	97-102