PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32607956-13	2020	Phytochemical profile of PtR2 showed a rich source of cardenolide structures, including ghalakinoside, calactin and calotropin derivatives.	calotropin	116-126	endogenous retrovirus group 9 member 1	Homo sapiens	25-29
31190898-2	2019	In this study, we aimed to investigate the effect CTP on colorectal cancer and the role of Yes-associated protein (YAP) in CTP-inhibited cell proliferation.	calotropin	123-126	yes-associated protein 1	Mus musculus	91-113
31190898-2	2019	In this study, we aimed to investigate the effect CTP on colorectal cancer and the role of Yes-associated protein (YAP) in CTP-inhibited cell proliferation.	calotropin	123-126	yes-associated protein 1	Mus musculus	115-118
31190898-4	2019	Western blotting and immunofluorescence were performed to determine CTP-induced YAP dephosphorylation and nuclear localization.	calotropin	68-71	yes-associated protein 1	Mus musculus	80-83
31190898-5	2019	Western blotting, siRNA transfection and RT-PCR analysis were carried out to investigate the mechanisms of CTP-mediated YAP activation.	calotropin	107-110	yes-associated protein 1	Mus musculus	120-123
31190898-8	2019	Moreover, we showed that CTP activates YAP in colorectal cancer cells.	calotropin	25-28	yes-associated protein 1	Mus musculus	39-42
31190898-9	2019	Mechanistically, CTP promotes LATS1 degradation via the ubiquitination/proteasome pathway, resulting in YAP dephosphorylation and nuclear localization, leading to induce YAP target genes expression in colorectal cancer cells.	calotropin	17-20	large tumor suppressor	Mus musculus	30-35
31190898-9	2019	Mechanistically, CTP promotes LATS1 degradation via the ubiquitination/proteasome pathway, resulting in YAP dephosphorylation and nuclear localization, leading to induce YAP target genes expression in colorectal cancer cells.	calotropin	17-20	yes-associated protein 1	Mus musculus	104-107
31190898-9	2019	Mechanistically, CTP promotes LATS1 degradation via the ubiquitination/proteasome pathway, resulting in YAP dephosphorylation and nuclear localization, leading to induce YAP target genes expression in colorectal cancer cells.	calotropin	17-20	yes-associated protein 1	Mus musculus	170-173
31190898-10	2019	Inhibition of YAP activity enhances CTP-mediated inhibition of cell proliferation, suggesting that YAP plays a protective role in CTP-induced antiproliferative effect.	calotropin	36-39	yes-associated protein 1	Mus musculus	14-17
31190898-10	2019	Inhibition of YAP activity enhances CTP-mediated inhibition of cell proliferation, suggesting that YAP plays a protective role in CTP-induced antiproliferative effect.	calotropin	130-133	yes-associated protein 1	Mus musculus	14-17
31190898-10	2019	Inhibition of YAP activity enhances CTP-mediated inhibition of cell proliferation, suggesting that YAP plays a protective role in CTP-induced antiproliferative effect.	calotropin	130-133	yes-associated protein 1	Mus musculus	99-102
31190898-11	2019	Conclusion: Our results demonstrate that CTP markedly inhibits tumor growth and activates a protective role of YAP in colorectal cancer cells, indicating that combination of CTP and YAP targeting drugs may be a promising strategy for colorectal cancer treatment.	calotropin	41-44	yes-associated protein 1	Mus musculus	111-114
31190898-11	2019	Conclusion: Our results demonstrate that CTP markedly inhibits tumor growth and activates a protective role of YAP in colorectal cancer cells, indicating that combination of CTP and YAP targeting drugs may be a promising strategy for colorectal cancer treatment.	calotropin	41-44	yes-associated protein 1	Mus musculus	182-185
31190898-11	2019	Conclusion: Our results demonstrate that CTP markedly inhibits tumor growth and activates a protective role of YAP in colorectal cancer cells, indicating that combination of CTP and YAP targeting drugs may be a promising strategy for colorectal cancer treatment.	calotropin	174-177	yes-associated protein 1	Mus musculus	111-114