PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 23219050-6 2013 Silencing of GSH1, GSH2 and GR1 decreased glutathione contents and the ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG), but increased CHT residues in plant tissues. tetrachloroisophthalonitrile 152-155 glutamate--cysteine ligase, chloroplastic Solanum lycopersicum 13-17 23219050-6 2013 Silencing of GSH1, GSH2 and GR1 decreased glutathione contents and the ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG), but increased CHT residues in plant tissues. tetrachloroisophthalonitrile 152-155 glutathione synthetase, chloroplastic Solanum lycopersicum 19-23 22497859-7 2012 Transcript levels for Prophenoloxidase-activating enzyme (PPOact), an immune end product, were elevated in larvae treated with myclobutanil and chlorothalonil (both are fungicides) (P<0.001). tetrachloroisophthalonitrile 144-158 proclotting enzyme Apis mellifera 22-56 22497859-7 2012 Transcript levels for Prophenoloxidase-activating enzyme (PPOact), an immune end product, were elevated in larvae treated with myclobutanil and chlorothalonil (both are fungicides) (P<0.001). tetrachloroisophthalonitrile 144-158 proclotting enzyme Apis mellifera 58-64 17680869-1 2007 Chlorothalonil (tetrachloro-1,3-benzenedicarbonitrile, CAS 1897-45-6) is a pesticide that has been on the market for many years. tetrachloroisophthalonitrile 0-14 BCAR1 scaffold protein, Cas family member Homo sapiens 55-58 11222871-3 2001 In the human prostate cancer cell lines LNCaP and PC-3, erbB-2 kinase was activated by pesticides of different chemical classes: (1) the organochlorine insecticides beta-hexa-chlorocyclohexane (beta-HCH), o,p"-dichlorodiphenyltrichloroethane (o,p"-DDT), and heptachlor epoxide; (2) the pyrethroid insecticide trans-permethrin, and (3) the fungicide chlorothalonil. tetrachloroisophthalonitrile 349-363 erb-b2 receptor tyrosine kinase 2 Homo sapiens 56-62 15174878-2 2004 The crystal structure prediction study, using a specifically developed anisotropic atom-atom potential for chlorothalonil, gave as the global minimum in the lattice energy a structure that was readily refined against powder diffraction data to the known form 1 (P2(1)/a). tetrachloroisophthalonitrile 107-121 H3 histone pseudogene 16 Homo sapiens 262-267 11093645-7 2000 The proposed method provided a simple and rapid analytical procedure for chlorothalonil in water bodies with detection limits of 2.86 microg/l for distilled water, 3.06 microg/l for ground water, 4.77 microg/l for tap water, and 9.23 microg/l for farm water. tetrachloroisophthalonitrile 73-87 nuclear RNA export factor 1 Homo sapiens 214-217 11222871-3 2001 In the human prostate cancer cell lines LNCaP and PC-3, erbB-2 kinase was activated by pesticides of different chemical classes: (1) the organochlorine insecticides beta-hexa-chlorocyclohexane (beta-HCH), o,p"-dichlorodiphenyltrichloroethane (o,p"-DDT), and heptachlor epoxide; (2) the pyrethroid insecticide trans-permethrin, and (3) the fungicide chlorothalonil. tetrachloroisophthalonitrile 349-363 chromobox 8 Homo sapiens 50-54 9703962-4 1998 We have earlier reported that on exposure to TPN under sublethal concentration, heat-shock protein Hsp104 was induced in the same way as in the mild heat-shock treatment (Fujita et al., Biochem. tetrachloroisophthalonitrile 45-48 chaperone ATPase HSP104 Saccharomyces cerevisiae S288C 99-105 9703962-10 1998 While Hsp104 was localized upon the circumference of the protein aggregates in mild heat-shocked cells, Hsp104 was distributed over the entire TPN-treated cells with no protein aggregates. tetrachloroisophthalonitrile 143-146 chaperone ATPase HSP104 Saccharomyces cerevisiae S288C 104-110 32887003-10 2020 Daconil suppressed the transcription activity of MLP in the roots. tetrachloroisophthalonitrile 0-7 cysteine and glycine rich protein 3 Homo sapiens 49-52 33277273-7 2020 Interestingly, fungicides indoor bioassays showed that only the DeltaMetR mutants are susceptive to chlorothalonil, a fungicide that could bind to the cysteine of glyceraldehyde-3-phosphate dehydrogenase. tetrachloroisophthalonitrile 100-114 CC77DRAFT_1011328 Alternaria alternata 163-203 8921341-8 1996 Oral administration of chlorthalonil (0.66 and 2.64 mmol/kg) resulted in a slight increase in the urinary excretion of gamma-glutamyltranspeptidase, indicative of nephrotoxicity. tetrachloroisophthalonitrile 23-36 gamma-glutamyltransferase 1 Rattus norvegicus 119-147 35121040-5 2022 Furthermore, three common pesticides, prochloraz (PCZ), difenoconazole (DFZ) and chlorothalonil (CTL), could significantly inhibit CYP3A-mediated DMM metabolism, and consequently trigger elevated exposure to DMM in vivo. tetrachloroisophthalonitrile 81-95 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 131-136 35121040-5 2022 Furthermore, three common pesticides, prochloraz (PCZ), difenoconazole (DFZ) and chlorothalonil (CTL), could significantly inhibit CYP3A-mediated DMM metabolism, and consequently trigger elevated exposure to DMM in vivo. tetrachloroisophthalonitrile 97-100 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 131-136 33186708-0 2020 Resveratrol relieves chlorothalonil-induced apoptosis and necroptosis through miR-15a/Bcl2-A20 axis in fish kidney cells. tetrachloroisophthalonitrile 21-35 microRNA 15a Homo sapiens 78-85 31563783-0 2019 Glutaredoxin S25 and its interacting TGACG motif-binding factor TGA2 mediate brassinosteroid-induced chlorothalonil metabolism in tomato plants. tetrachloroisophthalonitrile 101-115 glutaredoxin Solanum lycopersicum 0-12 31706243-6 2020 We demonstrated that CBZ and Chl together synergize to decrease sperm motility in vitro (CBZ 1.0 + Chl 0.1, CBZ 10.0 + CHl 1.0, CBZ 100.0 + Chl 10 muM in incubation medium for 24 h) and sperm concentration and motility in vivo with ICR mice (CBZ 0.1 + Chl 0.1, CBZ 1.0 + CHl 1.0, CBZ 10.0 + Chl 10 mg/kg body weight; oral gavage for five weeks). tetrachloroisophthalonitrile 29-32 cell adhesion molecule L1-like Mus musculus 119-124 31706243-6 2020 We demonstrated that CBZ and Chl together synergize to decrease sperm motility in vitro (CBZ 1.0 + Chl 0.1, CBZ 10.0 + CHl 1.0, CBZ 100.0 + Chl 10 muM in incubation medium for 24 h) and sperm concentration and motility in vivo with ICR mice (CBZ 0.1 + Chl 0.1, CBZ 1.0 + CHl 1.0, CBZ 10.0 + Chl 10 mg/kg body weight; oral gavage for five weeks). tetrachloroisophthalonitrile 29-32 cell adhesion molecule L1-like Mus musculus 271-276 31563783-3 2019 Here, we identified a tomato glutaredoxin gene GRXS25 which was induced by 24-epibrassinolide (EBR) and chlorothalonil (CHT) in a way dependent on apoplastic reactive oxygen species (ROS). tetrachloroisophthalonitrile 104-118 glutaredoxin Solanum lycopersicum 29-41 31563783-3 2019 Here, we identified a tomato glutaredoxin gene GRXS25 which was induced by 24-epibrassinolide (EBR) and chlorothalonil (CHT) in a way dependent on apoplastic reactive oxygen species (ROS). tetrachloroisophthalonitrile 120-123 glutaredoxin Solanum lycopersicum 29-41 31521458-4 2019 Notably, compounds b8 and b9 showed higher activity against Verticillium dahlia than chlorothalonil, with MIC values of 62.5 and 7.81 microg mL-1, respectively. tetrachloroisophthalonitrile 85-99 L1 cell adhesion molecule Mus musculus 141-145 27631504-4 2016 Atmospheric chlorothalonil concentrations were above 800 pg m-3 in several TSP samples, but <MDL in PM2.5 samples. tetrachloroisophthalonitrile 12-26 thrombospondin 1 Homo sapiens 75-78 31158606-9 2019 Moreover, as for carbendazim and chlorothalonil, the sensitivity (SENs) are 1.50 x 102 and 3.80 x 102 mL ng-1, the limits of detection (LODs) are 11 ng mL-1 and 4.3 ng mL-1, the limit of quantitation (LOQ) are 33.33 ng mL-1 and 13.03 ng mL-1, respectively. tetrachloroisophthalonitrile 33-47 L1 cell adhesion molecule Mus musculus 152-164 31158606-9 2019 Moreover, as for carbendazim and chlorothalonil, the sensitivity (SENs) are 1.50 x 102 and 3.80 x 102 mL ng-1, the limits of detection (LODs) are 11 ng mL-1 and 4.3 ng mL-1, the limit of quantitation (LOQ) are 33.33 ng mL-1 and 13.03 ng mL-1, respectively. tetrachloroisophthalonitrile 33-47 L1 cell adhesion molecule Mus musculus 152-156 31158606-9 2019 Moreover, as for carbendazim and chlorothalonil, the sensitivity (SENs) are 1.50 x 102 and 3.80 x 102 mL ng-1, the limits of detection (LODs) are 11 ng mL-1 and 4.3 ng mL-1, the limit of quantitation (LOQ) are 33.33 ng mL-1 and 13.03 ng mL-1, respectively. tetrachloroisophthalonitrile 33-47 L1 cell adhesion molecule Mus musculus 219-230 31158606-9 2019 Moreover, as for carbendazim and chlorothalonil, the sensitivity (SENs) are 1.50 x 102 and 3.80 x 102 mL ng-1, the limits of detection (LODs) are 11 ng mL-1 and 4.3 ng mL-1, the limit of quantitation (LOQ) are 33.33 ng mL-1 and 13.03 ng mL-1, respectively. tetrachloroisophthalonitrile 33-47 L1 cell adhesion molecule Mus musculus 168-172 31429367-8 2019 Multi-site fungicide chlorothalonil and MBC (methyl benzimidazole carbamate) fungicide thiophanate-methyl evinced moderate inhibition with mean EC50=35.31 and 62.83 microg mL-1, respectively. tetrachloroisophthalonitrile 21-35 L1 cell adhesion molecule Mus musculus 172-176 29747107-3 2018 Here, we showed that 24-epibrassinolide (EBR) significantly enhanced the expression of RESPIRATORY BURST OXIDASE HOMOLOG1 (RBOH1) and H2O2 accumulation in the apoplast of chlorothalonil (CHT, a broad spectrum nonsystemic fungicide)-treated tomato plants. tetrachloroisophthalonitrile 171-185 NADPH oxidase Solanum lycopersicum 87-121 29747107-3 2018 Here, we showed that 24-epibrassinolide (EBR) significantly enhanced the expression of RESPIRATORY BURST OXIDASE HOMOLOG1 (RBOH1) and H2O2 accumulation in the apoplast of chlorothalonil (CHT, a broad spectrum nonsystemic fungicide)-treated tomato plants. tetrachloroisophthalonitrile 171-185 NADPH oxidase Solanum lycopersicum 123-128 31120492-4 2019 Chlorothalonil exposure was found to have an effect on 1) honey bee resistance and/or tolerance to viral infection by decreasing the survival of bees following a viral challenge, 2) social immunity, by increasing the level of glucose oxidase activity, 3) nutrition, by decreasing levels of total carbohydrate and protein, and 4) development, by decreasing the total body weight, head width, and wing length of adult nurse and forager bees. tetrachloroisophthalonitrile 0-14 glucose oxidase Apis mellifera 226-241 27236431-2 2016 Here, we showed that MPK activity and transcripts of SlMPK1 and SlMPK2 were induced by chlorothalonil (CHT), a widely used fungicide, in tomato leaves. tetrachloroisophthalonitrile 87-101 Mitogen-activated protein kinase Solanum lycopersicum 53-59 27541960-7 2016 Dual-luciferase reporter gene assays indicated that both chlorothalonil and 4-hydroxychlorothalonil exerted estrogen receptor alpha (ERalpha) agonist activity with REC20 values of 2.4 x 10-8 M and 3.6 x 10-8 M, respectively. tetrachloroisophthalonitrile 57-71 estrogen receptor 1 Danio rerio 108-131 27541960-7 2016 Dual-luciferase reporter gene assays indicated that both chlorothalonil and 4-hydroxychlorothalonil exerted estrogen receptor alpha (ERalpha) agonist activity with REC20 values of 2.4 x 10-8 M and 3.6 x 10-8 M, respectively. tetrachloroisophthalonitrile 57-71 estrogen receptor 1 Danio rerio 133-140 27541960-9 2016 Lastly, we employed molecular docking to predict the binding affinity of chlorothalonil and 4-hydroxychlorothalonil with ERalpha or TRbeta. tetrachloroisophthalonitrile 73-87 estrogen receptor 1 Danio rerio 121-128 27541960-9 2016 Lastly, we employed molecular docking to predict the binding affinity of chlorothalonil and 4-hydroxychlorothalonil with ERalpha or TRbeta. tetrachloroisophthalonitrile 73-87 thyroid hormone receptor beta Danio rerio 132-138 27236431-2 2016 Here, we showed that MPK activity and transcripts of SlMPK1 and SlMPK2 were induced by chlorothalonil (CHT), a widely used fungicide, in tomato leaves. tetrachloroisophthalonitrile 87-101 mitogen-activated protein kinase 2 Solanum lycopersicum 64-70 26172540-1 2015 An immunosensor based on surface plasmon resonance (SPR-sensor) was developed to analyze chlorothalonil residues and maximum residue limits (MRLs; 0.5-50 mg/kg) in vegetables in Japan. tetrachloroisophthalonitrile 89-103 sepiapterin reductase Homo sapiens 52-55 26172540-3 2015 The SPR-sensor quantitatively determined chlorothalonil at concentrations ranging from 8.0 to 44 ng/mL, using TPN9A, a monoclonal antibody to chlorothalonil. tetrachloroisophthalonitrile 41-55 sepiapterin reductase Homo sapiens 4-7 26172540-3 2015 The SPR-sensor quantitatively determined chlorothalonil at concentrations ranging from 8.0 to 44 ng/mL, using TPN9A, a monoclonal antibody to chlorothalonil. tetrachloroisophthalonitrile 142-156 sepiapterin reductase Homo sapiens 4-7 26172540-6 2015 However, the SPR-sensor could determine chlorothalonil residues in vegetables at concentrations around the above MRLs. tetrachloroisophthalonitrile 40-54 sepiapterin reductase Homo sapiens 13-16 25761674-4 2015 Genome-wide microarray analysis showed that fungicide chlorothalonil (CHT) and BR co-upregulated 301 genes, including a set of detoxifying genes encoding cytochrome P450, oxidoreductase, hydrolase and transferase in tomato plants. tetrachloroisophthalonitrile 54-68 lipoxygenase Solanum lycopersicum 171-185