PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
20176747-5	2010	22(R)-OH-cholesterol negatively regulated hDIO2 in a dose-dependent manner (100 microM, approximately twofold), while it failed to affect the cDIO2 promoter.	22-hydroxycholesterol	0-20	iodothyronine deiodinase 2	Homo sapiens	42-47
20176747-10	2010	Our data indicate that hDIO2 transcription is negatively regulated by both 22(R)-OH-cholesterol and 9-cis RA, which is consistent with LXR/RXR involvement.	22-hydroxycholesterol	75-95	iodothyronine deiodinase 2	Homo sapiens	23-28
20176747-10	2010	Our data indicate that hDIO2 transcription is negatively regulated by both 22(R)-OH-cholesterol and 9-cis RA, which is consistent with LXR/RXR involvement.	22-hydroxycholesterol	75-95	retinoid X receptor alpha	Homo sapiens	139-142
20144211-5	2010	Testosterone production was induced either by activators of the cAMP/PKA pathway (hCG and dbcAMP) or substrates of steroidogenesis [22(R)-hydroxy-cholesterol (22(R)-OH-C), which is a substrate for the P450scc enzyme, and pregnenolone, which is the product of the P450scc-catalyzed step].	22-hydroxycholesterol	132-157	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	201-208
20144211-5	2010	Testosterone production was induced either by activators of the cAMP/PKA pathway (hCG and dbcAMP) or substrates of steroidogenesis [22(R)-hydroxy-cholesterol (22(R)-OH-C), which is a substrate for the P450scc enzyme, and pregnenolone, which is the product of the P450scc-catalyzed step].	22-hydroxycholesterol	132-157	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	263-270
19588995-4	2009	Among them, we found that LXRalpha ligands, i.e., T0901317, paxilline, and 22(R)-hydroxycholesterol, acted potently to induce the expression of ABCC2 at both mRNA and protein levels in human hepatocellular carcinoma HepG2 cells.	22-hydroxycholesterol	75-99	nuclear receptor subfamily 1 group H member 3	Homo sapiens	26-34
19588995-4	2009	Among them, we found that LXRalpha ligands, i.e., T0901317, paxilline, and 22(R)-hydroxycholesterol, acted potently to induce the expression of ABCC2 at both mRNA and protein levels in human hepatocellular carcinoma HepG2 cells.	22-hydroxycholesterol	75-99	ATP binding cassette subfamily C member 2	Homo sapiens	144-149
19243278-3	2009	22R-hydroxycholesterol was shown to protect against beta-amyloid (A beta(42))-induced neurotoxicity and block the formation of A beta oligomers.	22-hydroxycholesterol	0-22	amyloid beta precursor protein	Homo sapiens	66-72
19224871-2	2009	We show here that ORP2 also binds 22(R)-hydroxycholesterol [22(R)OHC], 7-ketocholesterol, and cholesterol, with 22(R)OHC being the highest affinity ligand of ORP2 (K(d) 1.4 x 10(-8) M).	22-hydroxycholesterol	34-58	oxysterol binding protein like 2	Homo sapiens	18-22
19224871-2	2009	We show here that ORP2 also binds 22(R)-hydroxycholesterol [22(R)OHC], 7-ketocholesterol, and cholesterol, with 22(R)OHC being the highest affinity ligand of ORP2 (K(d) 1.4 x 10(-8) M).	22-hydroxycholesterol	34-58	oxysterol binding protein like 2	Homo sapiens	158-162
19119143-6	2009	A similar effect was also observed with the use of 22R-hydroxycholesterol, an LXR ligand, in cultured hepatocytes.	22-hydroxycholesterol	51-73	nuclear receptor subfamily 1, group H, member 3	Mus musculus	78-81
19236478-5	2009	Co-application of either ciglitazone (PPARgamma activator), clofibrate (PPARalpha activator) or 22R (OH) cholesterol (LXR activator) with clobetasol prevented the decrease in involucrin, filaggrin and loricrin expression.	22-hydroxycholesterol	96-116	nuclear receptor subfamily 1, group H, member 3	Mus musculus	118-121
19236478-5	2009	Co-application of either ciglitazone (PPARgamma activator), clofibrate (PPARalpha activator) or 22R (OH) cholesterol (LXR activator) with clobetasol prevented the decrease in involucrin, filaggrin and loricrin expression.	22-hydroxycholesterol	96-116	loricrin	Mus musculus	201-209
19243278-3	2009	22R-hydroxycholesterol was shown to protect against beta-amyloid (A beta(42))-induced neurotoxicity and block the formation of A beta oligomers.	22-hydroxycholesterol	0-22	amyloid beta precursor protein	Homo sapiens	127-133
18980580-3	2009	[(3)H]Choline-labelling experiments showed that 25OH (25-hydroxycholesterol), 22OH (22-hydroxycholesterol) and 27OH (27-hydroxycholesterol) increased PtdCho synthesis in CHO cells as a result of CCTalpha (CTP:phosphocholine cytidylyltransferase alpha) translocation and activation at the NE (nuclear envelope).	22-hydroxycholesterol	78-82	choline-phosphate cytidylyltransferase A	Cricetulus griseus	195-203
18980580-3	2009	[(3)H]Choline-labelling experiments showed that 25OH (25-hydroxycholesterol), 22OH (22-hydroxycholesterol) and 27OH (27-hydroxycholesterol) increased PtdCho synthesis in CHO cells as a result of CCTalpha (CTP:phosphocholine cytidylyltransferase alpha) translocation and activation at the NE (nuclear envelope).	22-hydroxycholesterol	78-82	choline-phosphate cytidylyltransferase A	Cricetulus griseus	205-250
18980580-5	2009	in vitro, CCTalpha activity was stimulated 2- to 2.5-fold by liposomes containing 5 mol% 25OH, 22OH or 27OH.	22-hydroxycholesterol	95-99	choline-phosphate cytidylyltransferase A	Cricetulus griseus	10-18
19075690-7	2008	In Caco-2 cells TO901317 caused a 60 % upregulation and the natural LXR agonist 22-hydroxycholesterol a 40 % upregulation of apoM.	22-hydroxycholesterol	80-101	apolipoprotein M	Homo sapiens	125-129
17643522-6	2008	In adipocytes preincubated with 25 microg/mL oxLDL for 24 h, 22(R)-hydroxycholesterol could increase ABCA1 and LXR* mRNA levels and apoA-I-mediated cholesterol efflux.	22-hydroxycholesterol	61-85	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	101-106
17643522-6	2008	In adipocytes preincubated with 25 microg/mL oxLDL for 24 h, 22(R)-hydroxycholesterol could increase ABCA1 and LXR* mRNA levels and apoA-I-mediated cholesterol efflux.	22-hydroxycholesterol	61-85	nuclear receptor subfamily 1, group H, member 3	Mus musculus	111-115
17643522-6	2008	In adipocytes preincubated with 25 microg/mL oxLDL for 24 h, 22(R)-hydroxycholesterol could increase ABCA1 and LXR* mRNA levels and apoA-I-mediated cholesterol efflux.	22-hydroxycholesterol	61-85	apolipoprotein A-I	Mus musculus	132-138
18443233-6	2008	A well-established ligand of LXR, 22-(R)-hydroxycholesterol, also suppressed AT1R expression.	22-hydroxycholesterol	34-59	angiotensin II receptor type 1	Homo sapiens	77-81
17767055-7	2007	In adipocytes preincubated with 25 microg/mL ox-LDL for 24 hours, 22(R)-hydroxycholesterol could increase ABCA1 and LXRalpha mRNA and apoA-I-mediated cholesterol efflux, but had no effect on the SR-BI mRNA expression.	22-hydroxycholesterol	66-90	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	106-111
17916647-7	2007	RA, in combination with 22-hydroxycholesterol, could induce apo A-I gene expression without any impact on apo A-I mass.	22-hydroxycholesterol	24-45	apolipoprotein A1	Homo sapiens	60-67
17656736-3	2007	Here, we present evidence for a new cellular apoA-I binding site having a 9-fold higher capacity to bind apoA-I compared with the ABCA1 site in fibroblasts stimulated with 22-(R)-hydroxycholesterol/9-cis-retinoic acid.	22-hydroxycholesterol	172-197	apolipoprotein A1	Homo sapiens	45-51
17656736-3	2007	Here, we present evidence for a new cellular apoA-I binding site having a 9-fold higher capacity to bind apoA-I compared with the ABCA1 site in fibroblasts stimulated with 22-(R)-hydroxycholesterol/9-cis-retinoic acid.	22-hydroxycholesterol	172-197	apolipoprotein A1	Homo sapiens	105-111
17656736-3	2007	Here, we present evidence for a new cellular apoA-I binding site having a 9-fold higher capacity to bind apoA-I compared with the ABCA1 site in fibroblasts stimulated with 22-(R)-hydroxycholesterol/9-cis-retinoic acid.	22-hydroxycholesterol	172-197	ATP binding cassette subfamily A member 1	Homo sapiens	130-135
17644777-7	2007	LXRalpha activation by T0901317 and 22(R)-hydroxycholesterol not only rescued but also significantly increased LPL expression in the presence and absence of atorvastatin, respectively, whereas LXRalpha inhibition by 22(S)-hydroxycholesterol decreased LPL expression.	22-hydroxycholesterol	36-60	lipoprotein lipase	Homo sapiens	111-114
17644777-7	2007	LXRalpha activation by T0901317 and 22(R)-hydroxycholesterol not only rescued but also significantly increased LPL expression in the presence and absence of atorvastatin, respectively, whereas LXRalpha inhibition by 22(S)-hydroxycholesterol decreased LPL expression.	22-hydroxycholesterol	36-60	lipoprotein lipase	Homo sapiens	251-254
17644777-7	2007	LXRalpha activation by T0901317 and 22(R)-hydroxycholesterol not only rescued but also significantly increased LPL expression in the presence and absence of atorvastatin, respectively, whereas LXRalpha inhibition by 22(S)-hydroxycholesterol decreased LPL expression.	22-hydroxycholesterol	216-240	nuclear receptor subfamily 1 group H member 3	Homo sapiens	0-8
17644777-7	2007	LXRalpha activation by T0901317 and 22(R)-hydroxycholesterol not only rescued but also significantly increased LPL expression in the presence and absence of atorvastatin, respectively, whereas LXRalpha inhibition by 22(S)-hydroxycholesterol decreased LPL expression.	22-hydroxycholesterol	216-240	nuclear receptor subfamily 1 group H member 3	Homo sapiens	193-201
17329077-8	2007	Furthermore, our results found that 22(R)-hydroxycholesterol (22R-HC) could remove the inhibitory action of trichlorfon on progesterone biosynthesis, indicating that trichlorfon caused a disruption of cholesterol transport across mitochondrial membranes, which was further confirmed by the observation that trichlorfon dose-dependently inhibited the mRNA level of the steroidogenic acute regulatory protein (StAR).	22-hydroxycholesterol	36-60	steroidogenic acute regulatory protein	Homo sapiens	368-406
17329077-8	2007	Furthermore, our results found that 22(R)-hydroxycholesterol (22R-HC) could remove the inhibitory action of trichlorfon on progesterone biosynthesis, indicating that trichlorfon caused a disruption of cholesterol transport across mitochondrial membranes, which was further confirmed by the observation that trichlorfon dose-dependently inhibited the mRNA level of the steroidogenic acute regulatory protein (StAR).	22-hydroxycholesterol	36-60	steroidogenic acute regulatory protein	Homo sapiens	408-412
17329077-8	2007	Furthermore, our results found that 22(R)-hydroxycholesterol (22R-HC) could remove the inhibitory action of trichlorfon on progesterone biosynthesis, indicating that trichlorfon caused a disruption of cholesterol transport across mitochondrial membranes, which was further confirmed by the observation that trichlorfon dose-dependently inhibited the mRNA level of the steroidogenic acute regulatory protein (StAR).	22-hydroxycholesterol	62-68	steroidogenic acute regulatory protein	Homo sapiens	368-406
17329077-8	2007	Furthermore, our results found that 22(R)-hydroxycholesterol (22R-HC) could remove the inhibitory action of trichlorfon on progesterone biosynthesis, indicating that trichlorfon caused a disruption of cholesterol transport across mitochondrial membranes, which was further confirmed by the observation that trichlorfon dose-dependently inhibited the mRNA level of the steroidogenic acute regulatory protein (StAR).	22-hydroxycholesterol	62-68	steroidogenic acute regulatory protein	Homo sapiens	408-412
17767055-7	2007	In adipocytes preincubated with 25 microg/mL ox-LDL for 24 hours, 22(R)-hydroxycholesterol could increase ABCA1 and LXRalpha mRNA and apoA-I-mediated cholesterol efflux, but had no effect on the SR-BI mRNA expression.	22-hydroxycholesterol	66-90	nuclear receptor subfamily 1, group H, member 3	Mus musculus	116-124
17767055-7	2007	In adipocytes preincubated with 25 microg/mL ox-LDL for 24 hours, 22(R)-hydroxycholesterol could increase ABCA1 and LXRalpha mRNA and apoA-I-mediated cholesterol efflux, but had no effect on the SR-BI mRNA expression.	22-hydroxycholesterol	66-90	apolipoprotein A-I	Mus musculus	134-140
17767055-7	2007	In adipocytes preincubated with 25 microg/mL ox-LDL for 24 hours, 22(R)-hydroxycholesterol could increase ABCA1 and LXRalpha mRNA and apoA-I-mediated cholesterol efflux, but had no effect on the SR-BI mRNA expression.	22-hydroxycholesterol	66-90	scavenger receptor class B, member 1	Mus musculus	195-200
16999944-12	2006	Moreover, supplementing the medium with 22R-HC and pregnenolone as progesterone precursors for P450 side chain cleavage enzyme (P450scc) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD), respectively, resulted in no rise in progesterone production, making clear that MBP did not influence the P450scc and 3beta-HSD but on the rate-limiting step, cholesterol transportation into mitochondria.	22-hydroxycholesterol	40-46	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	95-126
17479410-9	2007	Moreover, incubation with 22R-HC and pregnenolone as progesterone precursors for P-450 side-chain cleavage enzyme (P450scc) and 3beta-hydroxysteroid dehydrogenase (3betaHSD) respectively resulted in no marked change in progesterone production, indicating that MBP did not influence P450scc and 3betaHSD but did exert an effect on cholesterol transportation into mitochondria, the rate-limiting step.	22-hydroxycholesterol	26-32	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	81-113
17479410-9	2007	Moreover, incubation with 22R-HC and pregnenolone as progesterone precursors for P-450 side-chain cleavage enzyme (P450scc) and 3beta-hydroxysteroid dehydrogenase (3betaHSD) respectively resulted in no marked change in progesterone production, indicating that MBP did not influence P450scc and 3betaHSD but did exert an effect on cholesterol transportation into mitochondria, the rate-limiting step.	22-hydroxycholesterol	26-32	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	115-122
17479410-9	2007	Moreover, incubation with 22R-HC and pregnenolone as progesterone precursors for P-450 side-chain cleavage enzyme (P450scc) and 3beta-hydroxysteroid dehydrogenase (3betaHSD) respectively resulted in no marked change in progesterone production, indicating that MBP did not influence P450scc and 3betaHSD but did exert an effect on cholesterol transportation into mitochondria, the rate-limiting step.	22-hydroxycholesterol	26-32	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	282-289
16999944-12	2006	Moreover, supplementing the medium with 22R-HC and pregnenolone as progesterone precursors for P450 side chain cleavage enzyme (P450scc) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD), respectively, resulted in no rise in progesterone production, making clear that MBP did not influence the P450scc and 3beta-HSD but on the rate-limiting step, cholesterol transportation into mitochondria.	22-hydroxycholesterol	40-46	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	128-135
16999944-12	2006	Moreover, supplementing the medium with 22R-HC and pregnenolone as progesterone precursors for P450 side chain cleavage enzyme (P450scc) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD), respectively, resulted in no rise in progesterone production, making clear that MBP did not influence the P450scc and 3beta-HSD but on the rate-limiting step, cholesterol transportation into mitochondria.	22-hydroxycholesterol	40-46	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	295-302
17072583-5	2006	Among them, the unrelated NR1HR ligands T0901317, GW3965 and (22R)-hydroxycholesterol were tested.	22-hydroxycholesterol	61-85	nuclear receptor subfamily 1, group H, member 3	Mus musculus	26-31
16146692-0	2005	Suppression of inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 22(R)-hydroxycholesterol requires de novo protein synthesis in activated macrophages.	22-hydroxycholesterol	87-111	prostaglandin-endoperoxide synthase 2	Homo sapiens	51-67
16878022-4	2006	When added to the cells as single agents, 15d-PGJ2, 22(R)-hydroxycholesterol, or T0901317 reduced the lipopolysaccharide-induced NO and tumor necrosis factor alpha production and the inducible NO synthase expression, and partially maintained mitochondrial respiration in a concentration-dependent manner.	22-hydroxycholesterol	52-76	tumor necrosis factor	Mus musculus	136-163
16878022-4	2006	When added to the cells as single agents, 15d-PGJ2, 22(R)-hydroxycholesterol, or T0901317 reduced the lipopolysaccharide-induced NO and tumor necrosis factor alpha production and the inducible NO synthase expression, and partially maintained mitochondrial respiration in a concentration-dependent manner.	22-hydroxycholesterol	52-76	nitric oxide synthase 2, inducible	Mus musculus	183-204
16522742-1	2006	Farnesoid X receptor (FXR), the receptor for bile acids, including chenodeoxycholic acid (CDCA), is a member of the nuclear receptor superfamily, which also includes the receptors for retinoic acid, vitamin D (D3), thyroid hormone, thiazolidinedione and 22(R)-hydroxycholesterol.	22-hydroxycholesterol	254-278	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	10-20
16522742-1	2006	Farnesoid X receptor (FXR), the receptor for bile acids, including chenodeoxycholic acid (CDCA), is a member of the nuclear receptor superfamily, which also includes the receptors for retinoic acid, vitamin D (D3), thyroid hormone, thiazolidinedione and 22(R)-hydroxycholesterol.	22-hydroxycholesterol	254-278	nuclear receptor subfamily 1 group H member 4	Homo sapiens	22-25
16498511-7	2006	While sterol regulatory element-binding protein-sensitive genes were downregulated, the authors identified a novel transporter, the ATP-binding cassette G1 (ABCG1) to be highly expressed in response to both cellular cholesterol loading and stimulation with the liver X receptor agonist 22-hydroxycholesterol.	22-hydroxycholesterol	286-307	ATP binding cassette subfamily G member 1	Homo sapiens	132-155
16498511-7	2006	While sterol regulatory element-binding protein-sensitive genes were downregulated, the authors identified a novel transporter, the ATP-binding cassette G1 (ABCG1) to be highly expressed in response to both cellular cholesterol loading and stimulation with the liver X receptor agonist 22-hydroxycholesterol.	22-hydroxycholesterol	286-307	ATP binding cassette subfamily G member 1	Homo sapiens	157-162
16289478-3	2005	ABCA1 upregulation by 8-(4-chlorophenylthio)adenosine 3":5"-cyclic monophosphate (cpt-cAMP) or 22 (R)-hydroxycholesterol (22-OH) and 9-cis retinoic acid (9cRA) increased the efflux to apo-AI of cellular sterols derived from AcLDL, but not of those from OxLDL.	22-hydroxycholesterol	95-120	ATP binding cassette subfamily A member 1	Homo sapiens	0-5
15887230-4	2005	The basal and 22-hydroxy-cholesterol (a membrane-permeable cholesterol, substrate of cytochrome P450 side-chain cleavage enzyme, P450scc)-stimulated pregnenolone release in mitochondria was inhibited by digoxin or ouabain.	22-hydroxycholesterol	14-36	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	129-136
15777536-3	2005	Both natural (22R-hydroxycholesterol/9-cis-retinoic acid) and synthetic (T0901317 and RO264456) LXR/RXR ligands increased ABCA1 and ABCG1 mRNAs in native macrophages and in cells loaded with acetylated LDL (acLDL).	22-hydroxycholesterol	14-36	retinoid X receptor alpha	Homo sapiens	100-103
15788406-2	2005	We observed that the oxysterol 22-hydroxycholesterol (22-HC) in combination with its obligate partner, 9-cis-retinoic acid (9-cis-RA), decreased surfactant phosphatidylcholine (PtdCho) synthesis by increasing phosphorylation of the regulatory enzyme CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha).	22-hydroxycholesterol	31-52	phosphate cytidylyltransferase 1A, choline	Homo sapiens	250-295
15788406-2	2005	We observed that the oxysterol 22-hydroxycholesterol (22-HC) in combination with its obligate partner, 9-cis-retinoic acid (9-cis-RA), decreased surfactant phosphatidylcholine (PtdCho) synthesis by increasing phosphorylation of the regulatory enzyme CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha).	22-hydroxycholesterol	31-52	phosphate cytidylyltransferase 1A, choline	Homo sapiens	297-305
16227152-6	2005	Th2 cells, but not Th1 cells expressed P450scc and 20alpha-HSD and produced progesterone from 22R-hydroxycholesterol in cooperation with 3beta-HSD-expressing mouse fibroblasts.	22-hydroxycholesterol	94-116	heart and neural crest derivatives expressed 2	Mus musculus	0-3
15777536-3	2005	Both natural (22R-hydroxycholesterol/9-cis-retinoic acid) and synthetic (T0901317 and RO264456) LXR/RXR ligands increased ABCA1 and ABCG1 mRNAs in native macrophages and in cells loaded with acetylated LDL (acLDL).	22-hydroxycholesterol	14-36	ATP binding cassette subfamily A member 1	Homo sapiens	122-127
15777536-3	2005	Both natural (22R-hydroxycholesterol/9-cis-retinoic acid) and synthetic (T0901317 and RO264456) LXR/RXR ligands increased ABCA1 and ABCG1 mRNAs in native macrophages and in cells loaded with acetylated LDL (acLDL).	22-hydroxycholesterol	14-36	ATP binding cassette subfamily G member 1	Homo sapiens	132-137
15314095-7	2004	The activation of the liver X receptor with 22(R)-hydroxycholesterol also increased cav-1 mRNA, whereas the inactive (S) isomer did not.	22-hydroxycholesterol	44-68	caveolin 1	Homo sapiens	84-89
14660648-1	2004	The dynamics of ABCA1-mediated apoA-I lipidation were investigated in intact human fibroblasts induced with 22(R)-hydroxycholesterol and 9-cis-retinoic acid (stimulated cells).	22-hydroxycholesterol	108-132	ATP binding cassette subfamily A member 1	Homo sapiens	16-21
15039140-5	2004	22HC/RA stimulated basolateral PtdCho efflux in cells via transcriptional activation of the ATP-binding cassette transporter 1 (ABCA1) gene.	22-hydroxycholesterol	0-4	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	92-126
15039140-5	2004	22HC/RA stimulated basolateral PtdCho efflux in cells via transcriptional activation of the ATP-binding cassette transporter 1 (ABCA1) gene.	22-hydroxycholesterol	0-4	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	128-133
15039140-7	2004	ABCA1 knockdown studies using ABCA1 siRNA or the ABCA1 inhibitor, glyburide, selectively attenuated 22HC/RA-driven basolateral PtdCho efflux.	22-hydroxycholesterol	100-104	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	0-5
15039140-7	2004	ABCA1 knockdown studies using ABCA1 siRNA or the ABCA1 inhibitor, glyburide, selectively attenuated 22HC/RA-driven basolateral PtdCho efflux.	22-hydroxycholesterol	100-104	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	30-35
15039140-7	2004	ABCA1 knockdown studies using ABCA1 siRNA or the ABCA1 inhibitor, glyburide, selectively attenuated 22HC/RA-driven basolateral PtdCho efflux.	22-hydroxycholesterol	100-104	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	30-35
14993242-2	2004	Both the LXR agonist T0901317 and the natural RXR/LXR agonists 22-hydroxycholesterol and 9-cis retinoic acid enhanced the basolateral efflux of beta-sitosterol without altering apical efflux.	22-hydroxycholesterol	63-84	retinoid X receptor alpha	Homo sapiens	46-49
14701824-2	2004	We investigated apoA-I-mediated cAMP signaling in cultured human fibroblasts induced with (22R)-hydroxycholesterol and 9-cis-retinoic acid (stimulated cells).	22-hydroxycholesterol	90-114	apolipoprotein A1	Homo sapiens	16-22
14999691-5	2004	The effect of an oxysterol (22(R)-hydroxycholesterol, 22-HC) on COX-2 expression in KMBC cells, a human cholangiocarcinoma cell line, was examined.	22-hydroxycholesterol	28-52	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-69
14715372-1	2004	22R-Hydroxycholesterol is an intermediate in the steroid biosynthesis pathway shown to exhibit a neuroprotective property against beta-amyloid (1-42) (Abeta) toxicity in rat PCl2 and human NT2N neuronal cells by binding and inactivating Abeta.	22-hydroxycholesterol	0-22	amyloid beta precursor protein	Rattus norvegicus	151-156
14594998-5	2004	Western blotting, ELISA assay, and mass spectrometry confirmed that apoE3 was secreted into the apical and basal chambers and that secretion was upregulated by thyroid hormone, 9-cis-retinoic acid, and 22(R)-hydroxycholesterol.	22-hydroxycholesterol	202-226	apolipoprotein E	Homo sapiens	68-73
14715372-1	2004	22R-Hydroxycholesterol is an intermediate in the steroid biosynthesis pathway shown to exhibit a neuroprotective property against beta-amyloid (1-42) (Abeta) toxicity in rat PCl2 and human NT2N neuronal cells by binding and inactivating Abeta.	22-hydroxycholesterol	0-22	amyloid beta precursor protein	Homo sapiens	237-242
14715372-2	2004	In search of potent 22R-hydroxycholesterol derivatives, we assessed the ability of a series of naturally occurring entities containing the 22R-hydroxycholesterol structure to protect PC12 cells against Abeta-induced neurotoxicity, determined by measuring changes in membrane potential, mitochondrial diaphorase activity, ATP levels and trypan blue uptake.	22-hydroxycholesterol	139-161	amyloid beta precursor protein	Rattus norvegicus	202-207
12909583-2	2003	ABCA1 mRNA and protein expression in primary cultures of rodent type II cells was sensitive to upregulation with 5 microM 9-cis-retinoic acid (9cRA) and 6.2 microM 22-hydroxycholesterol (22-OH).	22-hydroxycholesterol	164-185	ATP binding cassette subfamily A member 1	Homo sapiens	0-5
12909583-2	2003	ABCA1 mRNA and protein expression in primary cultures of rodent type II cells was sensitive to upregulation with 5 microM 9-cis-retinoic acid (9cRA) and 6.2 microM 22-hydroxycholesterol (22-OH).	22-hydroxycholesterol	187-192	ATP binding cassette subfamily A member 1	Homo sapiens	0-5
12909583-5	2003	Stimulation of ABCA1 in rat type II cells by 9cRA + 22-OH resulted in a four- or fivefold enhancement of efflux of radioactive phospholipid or cholesterol, respectively, from the pneumocytes to apolipoprotein AI (apo AI), whereas cAMP (0.3 mM) had no effect.	22-hydroxycholesterol	52-57	ATP binding cassette subfamily A member 1	Rattus norvegicus	15-20
12909583-5	2003	Stimulation of ABCA1 in rat type II cells by 9cRA + 22-OH resulted in a four- or fivefold enhancement of efflux of radioactive phospholipid or cholesterol, respectively, from the pneumocytes to apolipoprotein AI (apo AI), whereas cAMP (0.3 mM) had no effect.	22-hydroxycholesterol	52-57	apolipoprotein A1	Rattus norvegicus	194-211
12909583-5	2003	Stimulation of ABCA1 in rat type II cells by 9cRA + 22-OH resulted in a four- or fivefold enhancement of efflux of radioactive phospholipid or cholesterol, respectively, from the pneumocytes to apolipoprotein AI (apo AI), whereas cAMP (0.3 mM) had no effect.	22-hydroxycholesterol	52-57	apolipoprotein A1	Rattus norvegicus	213-219
14715372-6	2004	The neuroprotective property of these compounds was coupled to their ability to displace radiolabeled 22R-hydroxycholesterol from Abeta, suggesting that the Abeta-22R-hydroxycholesterol physicochemical interaction contributes to their beneficial effect.	22-hydroxycholesterol	102-124	amyloid beta precursor protein	Homo sapiens	130-135
14715372-6	2004	The neuroprotective property of these compounds was coupled to their ability to displace radiolabeled 22R-hydroxycholesterol from Abeta, suggesting that the Abeta-22R-hydroxycholesterol physicochemical interaction contributes to their beneficial effect.	22-hydroxycholesterol	102-124	amyloid beta precursor protein	Homo sapiens	157-162
14715372-8	2004	Computational docking simulations of 22R-hydroxycholesterol and its derivatives on Abeta identified two binding sites.	22-hydroxycholesterol	37-59	amyloid beta precursor protein	Homo sapiens	83-88
12542530-8	2003	22ROH also caused a partial reduction in ear thickness in LXRalpha-/- animals, however (approximately 50% of that observed in wild-type mice), suggesting that this receptor also mediates the anti-inflammatory effects of oxysterols.	22-hydroxycholesterol	0-5	nuclear receptor subfamily 1, group H, member 3	Mus musculus	58-66
12547833-0	2003	22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion.	22-hydroxycholesterol	0-22	ATP binding cassette subfamily A member 1	Rattus norvegicus	54-89
12547833-8	2003	In non-neuronal and neuronal cells overexpressing a human Swedish variant of amyloid precursor protein, 22R-hydroxycholesterol and 9-cis-retinoic acid induced ABCA1 expression and increased apoA-I-mediated cholesterol efflux consequently decreasing cellular cholesterol content.	22-hydroxycholesterol	104-126	ATP binding cassette subfamily A member 1	Homo sapiens	159-164
12547833-8	2003	In non-neuronal and neuronal cells overexpressing a human Swedish variant of amyloid precursor protein, 22R-hydroxycholesterol and 9-cis-retinoic acid induced ABCA1 expression and increased apoA-I-mediated cholesterol efflux consequently decreasing cellular cholesterol content.	22-hydroxycholesterol	104-126	apolipoprotein A1	Homo sapiens	190-196
12597997-8	2003	Furthermore, amphetamine significantly induced more progesterone production upon treatment with 22R-hydroxycholesterol (p < 0.05), a precursor of P450 side-chain cleavage enzyme (P450scc).	22-hydroxycholesterol	96-118	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	149-180
12597997-8	2003	Furthermore, amphetamine significantly induced more progesterone production upon treatment with 22R-hydroxycholesterol (p < 0.05), a precursor of P450 side-chain cleavage enzyme (P450scc).	22-hydroxycholesterol	96-118	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	182-189
12706121-0	2003	Membrane incorporation of 22-hydroxycholesterol inhibits chemokine receptor activity.	22-hydroxycholesterol	26-47	C-X-C motif chemokine receptor 4	Homo sapiens	57-75
12426219-6	2002	Furthermore, we also show that 22(R)hydroxycholesterol induces the production of reactive oxygen species in the artery wall cells, which can be removed by incubating the artery wall cells with apoA-I.	22-hydroxycholesterol	31-54	apolipoprotein A1	Homo sapiens	193-199
12706378-10	2003	GGPP blocked basal, 22-(R)-hydroxycholesterol- and cholesterol-induced ABCA1 expression.	22-hydroxycholesterol	20-45	ATP binding cassette subfamily A member 1	Homo sapiens	71-76
12384498-6	2002	ABCA1 was induced by treatment with retinoic acid and several oxysterols, including 22(R)-hydroxycholesterol and 24-hydroxycholesterol.	22-hydroxycholesterol	84-108	ATP binding cassette subfamily A member 1	Rattus norvegicus	0-5
12437582-0	2002	22R-Hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide.	22-hydroxycholesterol	0-22	amyloid beta precursor protein	Homo sapiens	100-120
12401893-0	2002	Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol.	22-hydroxycholesterol	107-130	ATP binding cassette subfamily A member 1	Homo sapiens	24-29
12401893-0	2002	Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol.	22-hydroxycholesterol	107-130	ATP binding cassette subfamily A member 1	Homo sapiens	74-79
12401893-3	2002	To specifically test this hypothesis, we examined ABCA1 protein expression in response to 9-cis-retinoic acid (9-cis-RA) and 22-R-hydroxycholesterol (22-R-OH-Chol) in a collection of human fibroblasts representing eight different mutations and observed that truncation mutations blunted the response to oxysterol stimulation and dominantly suppressed induction of the remaining full-length allele to 5-10% of wild-type levels.	22-hydroxycholesterol	125-148	ATP binding cassette subfamily A member 1	Homo sapiens	50-55
12176027-6	2002	The expression of ABCA1 was up-regulated during the differentiation and under the stimulation of LXR/RXR by the addition of 9-cis-retinoic acid (9-cis-RA) and 22-R-hydroxycholesterol (22-OH).	22-hydroxycholesterol	159-182	ATP binding cassette subfamily A member 1	Homo sapiens	18-23
12176027-6	2002	The expression of ABCA1 was up-regulated during the differentiation and under the stimulation of LXR/RXR by the addition of 9-cis-retinoic acid (9-cis-RA) and 22-R-hydroxycholesterol (22-OH).	22-hydroxycholesterol	159-182	retinoid X receptor alpha	Homo sapiens	101-104
12176027-6	2002	The expression of ABCA1 was up-regulated during the differentiation and under the stimulation of LXR/RXR by the addition of 9-cis-retinoic acid (9-cis-RA) and 22-R-hydroxycholesterol (22-OH).	22-hydroxycholesterol	184-189	ATP binding cassette subfamily A member 1	Homo sapiens	18-23
12176027-6	2002	The expression of ABCA1 was up-regulated during the differentiation and under the stimulation of LXR/RXR by the addition of 9-cis-retinoic acid (9-cis-RA) and 22-R-hydroxycholesterol (22-OH).	22-hydroxycholesterol	184-189	retinoid X receptor alpha	Homo sapiens	101-104
12176027-7	2002	Apolipoprotein-AI-mediated cholesterol efflux was dominant toward the basolateral side of polarized cells when stimulated by 9-cis-RA and 22-OH.	22-hydroxycholesterol	138-143	apolipoprotein A1	Homo sapiens	0-17
12628309-5	2002	Cotransfection with wild-type LXRalpha strongly enhanced 22(R)-hydroxycholesterol-inducible expression from the LXR-responsive reporter.	22-hydroxycholesterol	57-81	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	30-38
12032171-7	2002	When THP-1 cells were transfected with the ABCA1 promoter construct (-928 to +101 bp), promoter activity was significantly increased by treatment of 22(R)-hydroxycholesterol but not by LPS.	22-hydroxycholesterol	149-173	GLI family zinc finger 2	Homo sapiens	5-10
12032171-7	2002	When THP-1 cells were transfected with the ABCA1 promoter construct (-928 to +101 bp), promoter activity was significantly increased by treatment of 22(R)-hydroxycholesterol but not by LPS.	22-hydroxycholesterol	149-173	ATP binding cassette subfamily A member 1	Homo sapiens	43-48
11785958-4	2002	In the fibroblasts homozygous for G1158A/A255T, the immunoreactive mass of ABCA1 could not be detected, even when stimulated by 9-cis-retinoic acid and 22-R-hydroxycholesterol.	22-hydroxycholesterol	152-175	ATP binding cassette subfamily A member 1	Homo sapiens	75-80
11912279-6	2002	The inhibitory effect of TGF-beta1 on progesterone production was reversed by addition of 22R-hydroxycholesterol, a membrane-permeable analogue of cholesterol, or pregnenolone.	22-hydroxycholesterol	90-112	transforming growth factor beta 1	Homo sapiens	25-34
11861509-4	2002	Two structurally distinct inhibitors of MAPK kinase (MEK), PD 98059 and U 0126, abrogated hLH/hCG-induced ERK1/2 activation, but had no effect on hLH-, hCG-, or 22R-hydroxycholesterol-stimulated progesterone secretion.	22-hydroxycholesterol	161-183	mitogen-activated protein kinase kinase 7	Homo sapiens	53-56
11641412-2	2001	Expression of ABCA1 may be increased by certain oxysterols such as 22(R)-hydroxycholesterol via activation of the nuclear hormone receptor liver X receptor (LXR).	22-hydroxycholesterol	67-91	ATP binding cassette subfamily A member 1	Homo sapiens	14-19
11179691-6	2001	In Chinese hamster ovary cells, cotransfection with LXRalpha stimulated reporter activity by less than 2-fold and addition of 22(R)-hydroxycholesterol caused a small but significant stimulation of rat, human and hamster CYP7A1 promoter activity.	22-hydroxycholesterol	126-150	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	220-226
11357057-10	2001	Inhibition by PP2 (0.3-10 microM) was also observed for the metabolism of 22R-hydroxycholesterol (22R-OHChol) to aldosterone in H295R cells.	22-hydroxycholesterol	74-96	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	14-17
11356700-9	2001	Furthermore, incubation of Leydig cells with 22R-hydroxycholesterol (5 microg/ml, 2 h), a cholesterol substrate derivative that does not need an assisted process to be delivered to the inner mitochondrial membrane, reversed most of the inhibitory effect of LIF on the steroid hormone formation.	22-hydroxycholesterol	45-67	LIF interleukin 6 family cytokine	Homo sapiens	257-260
11287605-5	2001	Addition of an LXR ligand, 22(R)-hydroxycholesterol, increased the promoter activity.	22-hydroxycholesterol	27-51	nuclear receptor subfamily 1, group H, member 2	Mus musculus	15-18
11287605-7	2001	In HepG2 cells, SREBP-1c mRNA and precursor protein levels were induced by treatment with 22(R)-hydroxycholesterol and 9-cis-retinoic acid, confirming that endogenous LXR-RXR activation can induce endogenous SREBP-1c expression.	22-hydroxycholesterol	90-114	sterol regulatory element binding transcription factor 1	Homo sapiens	16-24
11287605-7	2001	In HepG2 cells, SREBP-1c mRNA and precursor protein levels were induced by treatment with 22(R)-hydroxycholesterol and 9-cis-retinoic acid, confirming that endogenous LXR-RXR activation can induce endogenous SREBP-1c expression.	22-hydroxycholesterol	90-114	nuclear receptor subfamily 1, group H, member 2	Mus musculus	167-170
11287605-7	2001	In HepG2 cells, SREBP-1c mRNA and precursor protein levels were induced by treatment with 22(R)-hydroxycholesterol and 9-cis-retinoic acid, confirming that endogenous LXR-RXR activation can induce endogenous SREBP-1c expression.	22-hydroxycholesterol	90-114	retinoid X receptor alpha	Homo sapiens	171-174
11287605-7	2001	In HepG2 cells, SREBP-1c mRNA and precursor protein levels were induced by treatment with 22(R)-hydroxycholesterol and 9-cis-retinoic acid, confirming that endogenous LXR-RXR activation can induce endogenous SREBP-1c expression.	22-hydroxycholesterol	90-114	sterol regulatory element binding transcription factor 1	Homo sapiens	208-216
11213355-8	2001	Cells were treated with dbcAMP, 22R-hydroxycholesterol or pregnenolone alone or in combination with lead acetate ranging from 10(-8) to 10(-5) M for 2 h. The expression of StAR protein stimulated by dbcAMP was suppressed by lead at about 50%.	22-hydroxycholesterol	32-54	steroidogenic acute regulatory protein	Mus musculus	172-176
11162896-3	2000	Cells were also treated with different concentration of TGFbeta1 in the presence of forskolin, combined steroid production was measured at the end of 48 h and after 3 h incubation with 22R-hydroxycholesterol.	22-hydroxycholesterol	185-207	transforming growth factor beta 1	Homo sapiens	56-64
10838129-10	2000	However, the conversion of 22(R)-hydroxycholesterol, pregnenolone and progesterone all were inhibited by prior exposure to OP and hCG.	22-hydroxycholesterol	27-51	chorionic gonadotropin subunit beta 5	Homo sapiens	130-133
10858438-2	2000	In cultured macrophages, ABC1 mRNA was induced in an additive fashion by 22(R)-hydroxycholesterol and 9-cis-retinoic acid (9CRA), suggesting induction by nuclear hormone receptors of the liver X receptor (LXR) and retinoid X receptor (RXR) family.	22-hydroxycholesterol	73-97	ATP binding cassette subfamily A member 1	Homo sapiens	25-29
10406462-5	1999	We show that in vitro the steroid receptor coactivator SRC-1 can be recruited by RXRalpha upon addition of its ligand, and to OR1 upon addition of 22(R)-OH-cholesterol, demonstrating that the latter can act as a direct ligand to OR1.	22-hydroxycholesterol	147-167	nuclear receptor coactivator 1	Homo sapiens	55-60
10692116-9	2000	22R-hydroxycholesterol increased transglutaminase 1 and involucrin promoter activity 2- to 3-fold.	22-hydroxycholesterol	0-22	transglutaminase 1	Homo sapiens	33-51
10692116-9	2000	22R-hydroxycholesterol increased transglutaminase 1 and involucrin promoter activity 2- to 3-fold.	22-hydroxycholesterol	0-22	involucrin	Homo sapiens	56-66
8947841-1	1996	Dihydroxycholesterol and pregnenolone were clearly detected on HPLC when 22R-hydroxycholesterol was incubated with a reconstituted P450scc system containing equimolar amounts of P450scc and adrenodoxin.	22-hydroxycholesterol	73-95	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	131-138
9331969-4	1997	The membrane-bound cytochrome P450scc exhibits cholesterol hydroxylase activity towards 22R-hydroxycholesterol in the presence of exogenous adrenodoxin and adrenodoxin reductase.	22-hydroxycholesterol	88-110	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	19-37
9578606-7	1998	Mutation of Ile-462 to Leu in human P450scc caused a decrease in the catalytic rate constant (kcat) with cholesterol as substrate, increased the Km for 22R-hydroxycholesterol, but did not affect the kinetic constants for 20 alpha-hydroxycholesterol.	22-hydroxycholesterol	152-174	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	36-43
9582502-10	1998	Furthermore, mIL-1 alpha (10 ng/ml) decreased conversion of (22R)-hydroxycholesterol to testosterone while the conversion of pregnenolone, 17-hydroxypregnenolone, dehydroepiandrosterone and androstenedione to testosterone were not affected.	22-hydroxycholesterol	60-84	interleukin 1 alpha	Mus musculus	13-24
9405411-6	1997	Addition of the hydrosoluble cholesterol derivative, 22R-hydroxycholesterol, increased steroid production by the PBR-negative R2C cells, indicating that the cholesterol transport mechanism was impaired.	22-hydroxycholesterol	53-75	translocator protein	Rattus norvegicus	113-116
8947841-1	1996	Dihydroxycholesterol and pregnenolone were clearly detected on HPLC when 22R-hydroxycholesterol was incubated with a reconstituted P450scc system containing equimolar amounts of P450scc and adrenodoxin.	22-hydroxycholesterol	73-95	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	178-185
1659519-9	1991	Furthermore, incubation of Leydig cells with 22R-hydroxycholesterol (5 micrograms/ml, 2 h) reversed most of the inhibitory effect of TNF-alpha on androgen production.	22-hydroxycholesterol	45-67	tumor necrosis factor	Homo sapiens	133-142
7988749-3	1994	The inhibition was not bypassed by the addition of dibutyryl-cAMP but was overcome, when 22(R)-hydroxycholesterol was added as a direct substrate for cytochrome P-450 side chain cleavage enzyme.	22-hydroxycholesterol	89-113	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	150-166
7994609-4	1994	Therefore, the paracrine factor (or factors) presents in SCM (or STM) which is testis specific and acts in synergy with dbcAMP and 22R-hydroxycholesterol, uses an alternative pathway to improve rat Leydig cell testosterone production since its biological effect is highly potent in absence and in presence of oLH.	22-hydroxycholesterol	131-153	sulfotransferase family 1A member 1	Rattus norvegicus	65-68
1331012-5	1992	Steroidogenic precursors (22-hydroxycholesterol, 17 alpha-hydroxypregnenolone, and dehydroepiandrosterone) restored testosterone secretion to control levels after preincubation with INF gamma or TNF alpha.	22-hydroxycholesterol	26-47	tumor necrosis factor	Mus musculus	195-204
1525048-8	1992	Only after its concentration had increased, presumably to a level where it could compete with 22R-hydroxycholesterol for binding to cytochrome P-450scc, was it converted to pregnenolone.	22-hydroxycholesterol	94-116	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	132-151
1525048-11	1992	The relative hydroxylation rates of 20 alpha-hydroxycholesterol, 22R-hydroxycholesterol and 20 alpha,22R-dihydroxycholesterol indicate that all three hydroxylations catalysed by human cytochrome P-450scc occur at approximately the same rate.	22-hydroxycholesterol	65-87	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	184-203
1326450-8	1992	Since the primary site of action of TGF beta appeared to be distal to cAMP formation, the effect of TGF beta on conversion of exogenous 22-hydroxy-cholesterol and pregnenolone to progesterone was determined in day 3 cultures.	22-hydroxycholesterol	136-158	transforming growth factor beta 1	Homo sapiens	100-108
1531626-5	1992	First, TGF beta 1 (1 ng/ml; 48 h) and EGF (10 ng/ml; 72 h) were, respectively, shown to reduce and enhance dehydroepiandrosterone (DHEA) formation (evaluated in the presence of 10(-5) M WIN 24540, an inhibitor of 3 beta HSDI) in Leydig cells when acutely (3 h) stimulated with hCG (0.01-1 ng/ml), but not when incubated with 22R-hydroxycholesterol (3 micrograms/ml).	22-hydroxycholesterol	325-347	transforming growth factor beta 1	Homo sapiens	7-17
1531626-5	1992	First, TGF beta 1 (1 ng/ml; 48 h) and EGF (10 ng/ml; 72 h) were, respectively, shown to reduce and enhance dehydroepiandrosterone (DHEA) formation (evaluated in the presence of 10(-5) M WIN 24540, an inhibitor of 3 beta HSDI) in Leydig cells when acutely (3 h) stimulated with hCG (0.01-1 ng/ml), but not when incubated with 22R-hydroxycholesterol (3 micrograms/ml).	22-hydroxycholesterol	325-347	epidermal growth factor	Homo sapiens	38-41
7826890-6	1994	An assay for P450scc activity was developed which utilized ovine small and large luteal cells in the presence of 22R-hydroxycholesterol and ovine high density lipoprotein.	22-hydroxycholesterol	113-135	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	13-20
8490050-4	1993	Examination of the rates of pregnenolone synthesis from 20 alpha-hydroxycholesterol, 22R-hydroxycholesterol and 20 alpha, 22R-dihydroxycholesterol by human and bovine cytochromes P-450scc revealed that the first hydroxylation (22R position) was rate-limiting for both in Tween-20 micelles.	22-hydroxycholesterol	85-107	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	179-187
1659519-10	1991	Indeed, the TNF-alpha (20 ng/ml, 72 h) inhibitory effect on testosterone production was limited to about 20% (P less than 0.03) in Leydig cells supplied with 22R-hydroxycholesterol.	22-hydroxycholesterol	158-180	tumor necrosis factor	Homo sapiens	12-21
1659519-11	1991	Such a moderate effect of the cytokine in the presence of 22R-hydroxycholesterol compared with that observed when androgen secretion was stimulated with the gonadotropin (up to 90% inhibition) indicate that TNF-alpha acts by dramatically reducing cholesterol substrate availability in the mitochondria.	22-hydroxycholesterol	58-80	tumor necrosis factor	Homo sapiens	207-216
2154488-14	1990	Cytochrome P-450 side chain cleavage activity, as measured by metabolism of (22R)-hydroxycholesterol, was not affected by PBR ligands in intact cells.	22-hydroxycholesterol	76-100	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-16
1869316-8	1991	Androgen production per Leydig cell, however, was significantly reduced in cells from Sxr males; this difference was apparent under basal conditions and following stimulation with hCG, dibutyryl cyclic AMP, 22R-hydroxycholesterol or pregnenolone.	22-hydroxycholesterol	207-229	transposition, Chr Y, Cattanach 1	Mus musculus	86-89
2242352-5	1990	Under the conditions employed, the apparent turnover number of cytochrome P-450scc for 22R-hydroxycholesterol was calculated to be 77 nmol/min/nmol P-450 from the amount of pregnenolone formed, whereas the apparent turnover number for 22R-hydroxycholest-4-en-3-one was 64 nmol/min/nmol P-450 with respect to the intermediate formation and 77 nmol/min/nmol P-450 with respect to the progesterone formation.	22-hydroxycholesterol	87-109	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	63-82
2161362-8	1990	Furthermore pBPB also inhibited 22R-OH-cholesterol-induced testosterone production illustrating that apart from its well-documented effect on PLA2, it also exerts a direct inhibitory effect on the steroidogenic enzymes.	22-hydroxycholesterol	32-50	phospholipase A2 group IB	Rattus norvegicus	142-146
2855024-6	1988	Our observations clearly indicate that given the proper hydroxy substrates (22R-hydroxycholesterol or 25-hydroxycholesterol), MA-10 Leydig cells are able to convert them into progesterone without any stimulation by steroidogenic stimuli, i.e. cAMP or hCG.	22-hydroxycholesterol	76-98	hypertrichosis 2 (generalised, congenital)	Homo sapiens	251-254
34564456-3	2021	We tested whether treating cultured immortalized mouse aortic endothelial cells (iMAEC) with the endogenous LXR agonist 22(R)-hydroxycholesterol, synthetic LXR agonist GW3965, endogenous RXR agonist 9-cis-retinoic acid, or synthetic RXR agonist SR11237 increases ABCA1 protein expression.	22-hydroxycholesterol	120-144	nuclear receptor subfamily 1, group H, member 3	Mus musculus	108-111
34564456-3	2021	We tested whether treating cultured immortalized mouse aortic endothelial cells (iMAEC) with the endogenous LXR agonist 22(R)-hydroxycholesterol, synthetic LXR agonist GW3965, endogenous RXR agonist 9-cis-retinoic acid, or synthetic RXR agonist SR11237 increases ABCA1 protein expression.	22-hydroxycholesterol	120-144	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	263-268
34564456-5	2021	However, we observed significant increases in both ABCA1 protein expression and apoAI-mediated cholesterol efflux when iMAEC were treated with a combination of either 22(R)-hydroxycholesterol and 9-cis-retinoic acid or GW3965 and SR11237.	22-hydroxycholesterol	167-191	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	51-56
2855024-7	1988	Since MA-10 Leydig cells can efficiently convert 22R-hydroxycholesterol--an intermediate in CSCC reaction--into progesterone, these results suggest that the key regulatory step in the mechanism of trophic hormone-stimulated steroid production is the first hydroxylation step of the 3 sequential monooxygenation reactions involved in the conversion of cholesterol to pregnenolone.	22-hydroxycholesterol	49-71	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	92-96
6723652-9	1984	Addition of oxidised adrenodoxin to oxygenated cytochrome P-450scc--cholesterol results in formation of 22-hydroxycholesterol.	22-hydroxycholesterol	104-125	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	47-66
3968683-0	1985	22-Hydroxycholesterol derivatives as HMG CoA reductase suppressors and serum cholesterol lowering agents.	22-hydroxycholesterol	0-21	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	37-54
3968683-3	1985	In tissue culture assays, 22-hydroxycholesterol as well as the side chain modified analogues were potent inhibitors of HMG CoA reductase.	22-hydroxycholesterol	26-47	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	119-136
33482284-6	2021	Incubation of isolated mitochondria with 22R-hydroxycholesterol revealed a marked inhibition in CYP11A1 function at the medullary level in STZ group.	22-hydroxycholesterol	41-63	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	96-103
6230077-8	1983	The calmodulin inhibitor trifluoperazine inhibited (22R)-22-hydroxycholesterol-stimulated steroidogenesis and negated the luliberin agonist effect.	22-hydroxycholesterol	51-78	calmodulin 1	Rattus norvegicus	4-14
6833254-4	1983	22R-Hydroxycholesterol and 20 alpha,22R-dihydroxycholesterol, intermediates in the cytochrome P-450scc-catalyzed conversion of cholesterol to pregnenolone, markedly influenced rates and equilibria of O2 and CO binding.	22-hydroxycholesterol	0-22	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	83-102
30655318-3	2019	Here, we show that sphingosine kinase (Sphk) activity was induced by the LXR agonist 22(R)-hydroxycholesterol and required for the stimulation of ABCA1-mediated cholesterol efflux to apolipoprotein A-I.	22-hydroxycholesterol	85-109	sphingosine kinase 1	Homo sapiens	19-37
30655318-3	2019	Here, we show that sphingosine kinase (Sphk) activity was induced by the LXR agonist 22(R)-hydroxycholesterol and required for the stimulation of ABCA1-mediated cholesterol efflux to apolipoprotein A-I.	22-hydroxycholesterol	85-109	sphingosine kinase 1	Homo sapiens	39-43
30655318-6	2019	Accordingly, S1P3-deficient macrophages were resistant to 22(R)-hydroxycholesterol-stimulated cholesterol efflux.	22-hydroxycholesterol	58-82	sphingosine-1-phosphate receptor 3	Homo sapiens	13-17
28729436-5	2017	Use of [3H] pregnenolone and free-diffusible 22(R)-hydroxycholesterol further confirmed that miR-132 promotes the production of 20alpha-OHP by upregulating 3beta-HSD and 20alpha-HSD.	22-hydroxycholesterol	45-69	microRNA 132	Homo sapiens	93-100
30825140-1	2019	Oxidative derivatives of cholesterol such as 22(R)-hydroxycholesterol, 24(S)-hydroxycholesterol, 25-hydroxycholesterol, and (25S),26-hydroxycholesterol are endogenous ligands for the liver X receptors (LXRalpha and LXRbeta).	22-hydroxycholesterol	45-69	nuclear receptor subfamily 1 group H member 3	Homo sapiens	202-210
30825140-1	2019	Oxidative derivatives of cholesterol such as 22(R)-hydroxycholesterol, 24(S)-hydroxycholesterol, 25-hydroxycholesterol, and (25S),26-hydroxycholesterol are endogenous ligands for the liver X receptors (LXRalpha and LXRbeta).	22-hydroxycholesterol	45-69	nuclear receptor subfamily 1 group H member 2	Homo sapiens	215-222
28741179-3	2017	Synthetic LXR agonist (GW3965) and endogenous LXR agonist (22R-hydroxycholesterol) significantly reduced the uptake of 3H-MPP+, a prototypic substrate of OCT2, in both OCT2- Chinese hamster ovary K1 and human renal proximal tubular cells (RPTEC/TERT1).	22-hydroxycholesterol	59-81	nuclear receptor subfamily 1, group H, member 3	Mus musculus	10-13
28741179-3	2017	Synthetic LXR agonist (GW3965) and endogenous LXR agonist (22R-hydroxycholesterol) significantly reduced the uptake of 3H-MPP+, a prototypic substrate of OCT2, in both OCT2- Chinese hamster ovary K1 and human renal proximal tubular cells (RPTEC/TERT1).	22-hydroxycholesterol	59-81	nuclear receptor subfamily 1, group H, member 3	Mus musculus	46-49
28741179-3	2017	Synthetic LXR agonist (GW3965) and endogenous LXR agonist (22R-hydroxycholesterol) significantly reduced the uptake of 3H-MPP+, a prototypic substrate of OCT2, in both OCT2- Chinese hamster ovary K1 and human renal proximal tubular cells (RPTEC/TERT1).	22-hydroxycholesterol	59-81	solute carrier family 22 member 2	Homo sapiens	154-158
28741179-3	2017	Synthetic LXR agonist (GW3965) and endogenous LXR agonist (22R-hydroxycholesterol) significantly reduced the uptake of 3H-MPP+, a prototypic substrate of OCT2, in both OCT2- Chinese hamster ovary K1 and human renal proximal tubular cells (RPTEC/TERT1).	22-hydroxycholesterol	59-81	solute carrier family 22 member 2	Homo sapiens	168-172
28729436-5	2017	Use of [3H] pregnenolone and free-diffusible 22(R)-hydroxycholesterol further confirmed that miR-132 promotes the production of 20alpha-OHP by upregulating 3beta-HSD and 20alpha-HSD.	22-hydroxycholesterol	45-69	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	156-165
26992564-5	2016	ORP2 silencing also increases cellular cholesterol, concomitant with decreased amounts of 22-hydroxycholesterol and 7-ketocholesterol, two molecules that have been shown to bind to ORP2.	22-hydroxycholesterol	90-111	oxysterol binding protein like 2	Homo sapiens	0-4
27052460-9	2017	Liquid chromatography and mass spectrometry indicated that the levels of 22-hydroxycholesterol, 25-hydroxycholesterol, and 24,25-epoxycholesterol were higher in the DDC-injured livers of SULT2B1-/- mice than in livers of WT mice.	22-hydroxycholesterol	73-94	sulfotransferase family, cytosolic, 2B, member 1	Mus musculus	187-194
27206966-3	2016	In this study, we demonstrate that MKP-1 expression is regulated at the post-transcriptional level by 22(R)-hydroxycholesterol [22(R)-HC] through a novel mechanism.	22-hydroxycholesterol	102-126	dual specificity phosphatase 1	Homo sapiens	35-40
26992564-5	2016	ORP2 silencing also increases cellular cholesterol, concomitant with decreased amounts of 22-hydroxycholesterol and 7-ketocholesterol, two molecules that have been shown to bind to ORP2.	22-hydroxycholesterol	90-111	oxysterol binding protein like 2	Homo sapiens	181-185
25283515-7	2014	An increase of 55% in LXR-alpha gene expression at RNA level was observed in Atorvastatin + 22-R hydroxycholestrol compared to 24% in Ascorbic acid + 22-ROH cholesterol.	22-hydroxycholesterol	150-168	nuclear receptor subfamily 1 group H member 3	Homo sapiens	22-31
25953328-5	2015	We have therefore investigated a potential role for PKC in the action of LXR/RXR agonist 22-(R)-hydroxycholesterol (22-(R)-HC)/9-cis-retinoic acid (9cRA) in THP-1 macrophages, including the induction of ABCA1 expression.	22-hydroxycholesterol	89-114	proline rich transmembrane protein 2	Homo sapiens	52-55
25953328-5	2015	We have therefore investigated a potential role for PKC in the action of LXR/RXR agonist 22-(R)-hydroxycholesterol (22-(R)-HC)/9-cis-retinoic acid (9cRA) in THP-1 macrophages, including the induction of ABCA1 expression.	22-hydroxycholesterol	89-114	retinoid X receptor alpha	Homo sapiens	77-80
25557254-0	2015	22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRalpha.	22-hydroxycholesterol	0-23	C-C motif chemokine ligand 2	Homo sapiens	115-120
25557254-0	2015	22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRalpha.	22-hydroxycholesterol	0-23	nuclear receptor subfamily 1 group H member 3	Homo sapiens	133-141
25557254-4	2015	Here, we show the role of liver X receptor alpha (LXRalpha) in the regulation of MCP-1 expression during the development of ethanol-induced fatty liver injury, using an antagonist, 22-S-hydroxycholesterol (22-S-HC).	22-hydroxycholesterol	181-204	nuclear receptor subfamily 1 group H member 3	Homo sapiens	50-58
25752819-5	2015	We have, therefore, investigated a potential role for PKC in the action of LXR/RXR agonist 22-(R)-hydroxycholesterol (22-(R)-HC)/9-cis-retinoic acid (9cRA) in THP-1 macrophages, including the induction of ABCA1 expression.	22-hydroxycholesterol	91-116	proline rich transmembrane protein 2	Homo sapiens	54-57
25752819-5	2015	We have, therefore, investigated a potential role for PKC in the action of LXR/RXR agonist 22-(R)-hydroxycholesterol (22-(R)-HC)/9-cis-retinoic acid (9cRA) in THP-1 macrophages, including the induction of ABCA1 expression.	22-hydroxycholesterol	91-116	retinoid X receptor alpha	Homo sapiens	79-82
25557254-4	2015	Here, we show the role of liver X receptor alpha (LXRalpha) in the regulation of MCP-1 expression during the development of ethanol-induced fatty liver injury, using an antagonist, 22-S-hydroxycholesterol (22-S-HC).	22-hydroxycholesterol	181-204	C-C motif chemokine ligand 2	Homo sapiens	81-86
25557254-4	2015	Here, we show the role of liver X receptor alpha (LXRalpha) in the regulation of MCP-1 expression during the development of ethanol-induced fatty liver injury, using an antagonist, 22-S-hydroxycholesterol (22-S-HC).	22-hydroxycholesterol	206-213	nuclear receptor subfamily 1 group H member 3	Homo sapiens	50-58
25557254-4	2015	Here, we show the role of liver X receptor alpha (LXRalpha) in the regulation of MCP-1 expression during the development of ethanol-induced fatty liver injury, using an antagonist, 22-S-hydroxycholesterol (22-S-HC).	22-hydroxycholesterol	206-213	C-C motif chemokine ligand 2	Homo sapiens	81-86
24704452-0	2014	22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARgamma-LXRalpha-ABCA1 pathway in cholesterosis of the gallbladder.	22-hydroxycholesterol	0-24	peroxisome proliferator activated receptor gamma	Homo sapiens	93-102
24704452-9	2014	Our data showed that 22(R)-hydroxycholesterol can modestly up-regulate LXRalpha while simultaneously increasing ABCA1 by 56%.	22-hydroxycholesterol	21-45	nuclear receptor subfamily 1 group H member 3	Homo sapiens	71-79
24704452-0	2014	22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARgamma-LXRalpha-ABCA1 pathway in cholesterosis of the gallbladder.	22-hydroxycholesterol	0-24	nuclear receptor subfamily 1 group H member 3	Homo sapiens	103-111
24704452-9	2014	Our data showed that 22(R)-hydroxycholesterol can modestly up-regulate LXRalpha while simultaneously increasing ABCA1 by 56%.	22-hydroxycholesterol	21-45	ATP binding cassette subfamily A member 1	Homo sapiens	112-117
24704452-10	2014	The combination of 22(R)-hydroxycholesterol and pioglitazone resulted in a 3.64-fold increase in ABCA1 expression and a high rate of cholesterol efflux.	22-hydroxycholesterol	19-43	ATP binding cassette subfamily A member 1	Homo sapiens	97-102
24704452-0	2014	22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARgamma-LXRalpha-ABCA1 pathway in cholesterosis of the gallbladder.	22-hydroxycholesterol	0-24	ATP binding cassette subfamily A member 1	Homo sapiens	112-117
24704452-12	2014	In conclusion, the present findings indicate that the anti-lipid deposition action of 22(R)-hydroxycholesterol combined with pioglitazone involves the activation of the PPARgamma-LXRalpha-ABCA1 pathway, increased ABCA1 expression and the efflux of cholesterol from GBECs.	22-hydroxycholesterol	86-110	peroxisome proliferator activated receptor gamma	Homo sapiens	169-178
24704452-5	2014	While pioglitazone can regulate the activation of PPARgamma, 22(R)-hydroxycholesterol can activate LXRalpha and is a metabolic intermediate in the biosynthesis of steroid hormones.	22-hydroxycholesterol	61-85	nuclear receptor subfamily 1 group H member 3	Homo sapiens	99-107
24704452-12	2014	In conclusion, the present findings indicate that the anti-lipid deposition action of 22(R)-hydroxycholesterol combined with pioglitazone involves the activation of the PPARgamma-LXRalpha-ABCA1 pathway, increased ABCA1 expression and the efflux of cholesterol from GBECs.	22-hydroxycholesterol	86-110	nuclear receptor subfamily 1 group H member 3	Homo sapiens	179-187
21652712-10	2011	Endogenous up-regulation of SREBP-1c in INS-1 cells through the activation of liver X receptor and retinoid X receptor by 9-cis-retinoic acid and 22-hydroxycholesterol inhibited PDX-1 mRNA and protein expression.	22-hydroxycholesterol	146-167	sterol regulatory element binding transcription factor 1	Rattus norvegicus	28-36
24704452-12	2014	In conclusion, the present findings indicate that the anti-lipid deposition action of 22(R)-hydroxycholesterol combined with pioglitazone involves the activation of the PPARgamma-LXRalpha-ABCA1 pathway, increased ABCA1 expression and the efflux of cholesterol from GBECs.	22-hydroxycholesterol	86-110	ATP binding cassette subfamily A member 1	Homo sapiens	188-193
24704452-12	2014	In conclusion, the present findings indicate that the anti-lipid deposition action of 22(R)-hydroxycholesterol combined with pioglitazone involves the activation of the PPARgamma-LXRalpha-ABCA1 pathway, increased ABCA1 expression and the efflux of cholesterol from GBECs.	22-hydroxycholesterol	86-110	ATP binding cassette subfamily A member 1	Homo sapiens	213-218
24269243-7	2014	In a mammalian two-hybrid assay, 25-hydroxy-7-DHC and 26/27-hydroxy-7-DHC induced interaction between LXRalpha and a coactivator fragment less efficiently than a natural LXR agonist, 22(R)-hydroxycholesterol.	22-hydroxycholesterol	183-207	nuclear receptor subfamily 1 group H member 3	Homo sapiens	102-110
23720350-3	2013	In this report, we demonstrated the ability of LXR ligands, both endogenous [22 (R)-hydroxycholesterol] and synthetic (T0901317 and GW3965), to reduce CFTR-mediated Cl(-) secretion in a type I Madin-Darby canine kidney (MDCK) cell line and in murine primary inner medullary collecting duct (IMCD) cells, based on measurements of [Arg(8)]-vasopressin-induced Cl(-) current.	22-hydroxycholesterol	77-102	CF transmembrane conductance regulator	Canis lupus familiaris	151-155
22973050-7	2012	Knockdown of ATAD3A, but not ANT or optic atrophy type 1, in Leydig cells resulted in a significant decrease in hormone-induced, but not 22R-hydroxycholesterol-supported, steroid production.	22-hydroxycholesterol	137-159	ATPase family AAA domain containing 3A	Homo sapiens	13-19
23039857-6	2012	During annealing of the hydroperoxy-ferric P450scc intermediates at 185 K, they convert to the primary product complex in which CH has been converted to 22-HC.	22-hydroxycholesterol	153-158	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	43-50
22169006-3	2012	Exposure of renal S2 cells expressing hOAT1 to LXR agonists (TO901317 and GW3965) and their endogenous ligand [22(R)-hydroxycholesterol] led to the inhibition of hOAT1-mediated [(14)C]PAH uptake.	22-hydroxycholesterol	111-135	solute carrier family 22 member 6	Homo sapiens	38-43
22169006-3	2012	Exposure of renal S2 cells expressing hOAT1 to LXR agonists (TO901317 and GW3965) and their endogenous ligand [22(R)-hydroxycholesterol] led to the inhibition of hOAT1-mediated [(14)C]PAH uptake.	22-hydroxycholesterol	111-135	solute carrier family 22 member 6	Homo sapiens	162-167
21704137-6	2011	Both 8-Br-cAMP (for cAMP signaling) and 22R-hydroxycholesterol (22-diol, for P450 cholesterol side chain cleavage enzyme P450scc activity) significantly increased T production in ALCs treated with BDE-47 from 10(-7) to 10(-5)M. The results of this study indicate that environment-related level of BDE-47 in vitro increased T production in a dose-dependent manner.	22-hydroxycholesterol	40-62	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	121-128
23665353-0	2013	Stereo specific platelet inhibition by the natural LXR agonist 22(R)-OH-cholesterol and its fluorescence labelling with preserved bioactivity and chiral handling in macrophages.	22-hydroxycholesterol	63-83	nuclear receptor subfamily 1, group H, member 3	Mus musculus	51-54
23779096-11	2013	3beta-hydroxysteroid dehydrogenase (3betaHSD) enzyme activity was determined by measuring the progesterone produced when cells were provided with an excess of 22-hydroxy-cholesterol as substrate following an incubation with hCG (1 IU/ml) and/or adiponectin (10 ng/ml).	22-hydroxycholesterol	159-181	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	0-34
23779096-11	2013	3beta-hydroxysteroid dehydrogenase (3betaHSD) enzyme activity was determined by measuring the progesterone produced when cells were provided with an excess of 22-hydroxy-cholesterol as substrate following an incubation with hCG (1 IU/ml) and/or adiponectin (10 ng/ml).	22-hydroxycholesterol	159-181	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	36-44
23223141-11	2013	Other LXR ligands, 22(R)-hydroxycholesterol (22(R)HC) and GW3965, also activated ERK and suppressed melanogenesis.	22-hydroxycholesterol	19-43	nuclear receptor subfamily 1, group H, member 3	Mus musculus	6-9
23223141-11	2013	Other LXR ligands, 22(R)-hydroxycholesterol (22(R)HC) and GW3965, also activated ERK and suppressed melanogenesis.	22-hydroxycholesterol	19-43	mitogen-activated protein kinase 1	Homo sapiens	81-84
23110859-5	2012	Treatment of JAR cells or human placental explants with 22-(R)-hydroxycholesterol or T0901317 resulted in a clear increase in sEng that was dependent on LXR.	22-hydroxycholesterol	56-81	nuclear receptor subfamily 1, group H, member 3	Mus musculus	153-156
23163651-9	2012	LXR-alpha agonist 22(R)-hydroxycholesterol treatment significantly decreases melanocyte adhesion, apoptosis and proliferation.	22-hydroxycholesterol	18-42	nuclear receptor subfamily 1 group H member 3	Homo sapiens	0-9
21652712-10	2011	Endogenous up-regulation of SREBP-1c in INS-1 cells through the activation of liver X receptor and retinoid X receptor by 9-cis-retinoic acid and 22-hydroxycholesterol inhibited PDX-1 mRNA and protein expression.	22-hydroxycholesterol	146-167	pancreatic and duodenal homeobox 1	Rattus norvegicus	178-183
21527500-6	2011	cAMP accumulation in response to hCG stimulation in primary cultures of Leydig cells from Mek1(f/f);Mek2(-/-);iCre(+) mice is normal, but basal testosterone and testosterone syntheses provoked by addition of hCG or a cAMP analog, or by addition of substrates such as 22-hydroxycholesterol or pregnenolone, are barely detectable.	22-hydroxycholesterol	267-288	hypertrichosis 2 (generalised, congenital)	Homo sapiens	33-36
20695472-5	2010	These effects of 1 were enhanced synergistically in the presence of an LXR agonist, 22(R)-hydroxycholesterol.	22-hydroxycholesterol	84-108	nuclear receptor subfamily 1, group H, member 3	Mus musculus	71-74
21307141-9	2011	Baseline levels of CYP17 steroid products were higher in primary cells and significantly increased in the presence of 22-hydroxycholesterol.	22-hydroxycholesterol	118-139	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	19-24
21159775-3	2011	Herein, we present the 2.5-A crystal structure of CYP11A1 in complex with the first reaction intermediate, 22HC.	22-hydroxycholesterol	107-111	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	50-57
20844007-6	2010	Incubating SR-BI KD cells with 22-hydroxy cholesterol did not overcome the reduction in progesterone secretion.	22-hydroxycholesterol	31-53	scavenger receptor class B member 1	Homo sapiens	11-16
20944148-3	2010	Cancer cell lines with higher LXRalpha mRNA expression were more sensitive to 22(R)-hydroxycholesterol-induced inhibition.	22-hydroxycholesterol	78-102	nuclear receptor subfamily 1 group H member 3	Homo sapiens	30-38