PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34641993-12	2021	Cultivation of SSCs on alginate hydrogel can affect Oct4, Sox2 and Nanos2 expression.	Alginates	23-31	POU domain, class 5, transcription factor 1	Mus musculus	52-56
34641993-12	2021	Cultivation of SSCs on alginate hydrogel can affect Oct4, Sox2 and Nanos2 expression.	Alginates	23-31	SRY (sex determining region Y)-box 2	Mus musculus	58-62
34641993-12	2021	Cultivation of SSCs on alginate hydrogel can affect Oct4, Sox2 and Nanos2 expression.	Alginates	23-31	nanos C2HC-type zinc finger 2	Mus musculus	67-73
34525809-0	2021	Evaluation of Interleukin-4-Loaded Sodium Alginate-Chitosan Microspheres for Their Support of Microvascularization in Engineered Tissues.	Alginates	35-50	interleukin 4	Mus musculus	14-27
34525809-3	2021	We developed a capillary construct composed of a gelatin methacrylate-based cell-laden hydrogel framework complexed with interleukin-4 (IL-4)-loaded alginate-chitosan (AC) microspheres and endothelial progenitor cells (EPCs) and RAW264.7 macrophages as model cells.	Alginates	149-157	interleukin 4	Mus musculus	121-134
34525809-3	2021	We developed a capillary construct composed of a gelatin methacrylate-based cell-laden hydrogel framework complexed with interleukin-4 (IL-4)-loaded alginate-chitosan (AC) microspheres and endothelial progenitor cells (EPCs) and RAW264.7 macrophages as model cells.	Alginates	149-157	interleukin 4	Mus musculus	136-140
34587744-2	2021	In this study, casein-alginate conjugates were prepared using a transacylation reaction between different types of caseins and propylene glycol alginate (PGA) at pH 11.0.	Alginates	22-30	amyloid beta precursor protein	Homo sapiens	62-63
34587744-7	2021	The present findings suggest a transacylation reaction can be used to prepare protein-alginate conjugates with novel emulsifying properties.	Alginates	86-94	amyloid beta precursor protein	Homo sapiens	29-30
34309163-1	2021	Alginate composite hydrogels that exhibit highly sensitive stimuli-responsive behavior were used for signal-stimulated release of pre-loaded insulin.	Alginates	0-8	insulin	Homo sapiens	141-148
34309163-7	2021	This process allowed release of insulin from the alginate beads.	Alginates	49-57	insulin	Homo sapiens	32-39
34641109-0	2021	Fabrication of Eco-Friendly Polyelectrolyte Membranes Based on Sulfonate Grafted Sodium Alginate for Drug Delivery, Toxic Metal Ion Removal and Fuel Cell Applications.	Alginates	81-96	ciliogenesis associated kinase 1	Homo sapiens	15-18
34492582-4	2021	Here, we engineered alginate hydrogels to present integrin- and syndecan-binding peptides alone or in combination (cyclic RGD and AG73, respectively) to introduce bioactive features into the alginate gels.	Alginates	20-28	syndecan 1	Homo sapiens	64-72
34215034-4	2021	Subsequently, a lot of phosphate groups were introduced by the specific recognition between anti-EGFR and exosomes, then sodium alginate grafted Glycidyl propargyl ether (SA-g-GPE) prepared via ROP was attached to the exosomes through PO43-Zr4+-COOH coordination bond.	Alginates	121-136	epidermal growth factor receptor	Homo sapiens	97-101
34641215-1	2021	We hypothesized that a composite of 3D porous melt-electrowritten poly-e-caprolactone (PCL) coated throughout with a porous and slowly biodegradable fibrin/alginate (FA) matrix would accelerate bone repair due to its angiogenic potential.	Alginates	156-164	glycogen synthase kinase 3 beta	Rattus norvegicus	166-168
34603816-0	2021	Adsorption of As(III), Pb(II), and Zn(II) from Wastewater by Sodium Alginate Modified Materials.	Alginates	61-76	submaxillary gland androgen regulated protein 3B	Homo sapiens	23-29
34603816-2	2021	The present study examined the removal rate and adsorption capacity of alginate composite gel for removal of wastewater As(III), Pb(II), and Zn(II).	Alginates	71-79	submaxillary gland androgen regulated protein 3B	Homo sapiens	129-135
34603816-4	2021	The results showed the high efficiency of sodium alginate composite gel for removal of wastewater As(III), Pb(II), and Zn(II).	Alginates	42-57	submaxillary gland androgen regulated protein 3B	Homo sapiens	107-113
34474823-2	2021	Here, a novel hydrogel was fabricated based on carboxymethyl chitosan (CS) and aldehyde functionalized sodium alginate via Schiff base reaction.	Alginates	103-118	citrate synthase	Rattus norvegicus	71-73
34511841-5	2021	In this study, we developed an integrated hollow core-shell-shell hydrogel tube of gelatin/alginate/acrylamide-bacterial nanocellulose(GAA) that meets the anticoagulant requirements for the inner tubing layer as well as the highly elastic soft material needed for the outer layer.	Alginates	91-99	alpha glucosidase	Homo sapiens	135-138
34217903-4	2021	Herein, we synthesized a sodium alginate (SA)/collagen type I (Col)/SDF-1 hydrogel and investigated whether the SA/Col/SDF-1 hydrogel loaded with bone marrow-derived mesenchymal stem cells (BMSCs) had therapeutic effects on a TBI model.	Alginates	25-40	C-X-C motif chemokine ligand 12	Rattus norvegicus	68-73
34217903-4	2021	Herein, we synthesized a sodium alginate (SA)/collagen type I (Col)/SDF-1 hydrogel and investigated whether the SA/Col/SDF-1 hydrogel loaded with bone marrow-derived mesenchymal stem cells (BMSCs) had therapeutic effects on a TBI model.	Alginates	42-44	C-X-C motif chemokine ligand 12	Rattus norvegicus	68-73
34477718-4	2021	By placing SERS probes in the alginate extracellular layer, a high contrast can be obtained with negligible toxicity.	Alginates	30-38	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	11-15
34405997-4	2021	Through the addition of an adequate oxidant and catalase, the catechol-conjugated alginate (C-ALG) hydrogel showed rapid gelation for less than 5 min, similar mechanical properties to lung tissue, slight swelling degree, good cell compatibility, and enough tissue adhesion for localization around the lung tissue.	Alginates	82-90	catalase	Homo sapiens	48-56
34474857-4	2021	In addition, hPL was encapsulated in alginate microbeads and incorporated into CPCC+DOX (CPCC+DOX+ hPL).	Alginates	37-45	galectin 1	Homo sapiens	13-16
34251797-0	2021	Pancreatic Extracellular Matrix/Alginate Hydrogels Provide a Supportive Microenvironment for Insulin-Producing Cells.	Alginates	32-40	insulin	Homo sapiens	93-100
34265755-6	2021	Alginate/gelatin-based hydrogels enabled spheroids fusion, which was further facilitated by addition of VEGF.	Alginates	0-8	vascular endothelial growth factor A	Homo sapiens	104-108
34952735-5	2021	We hypothesize that the application of a microcapillary gelatin-alginate hydrogel loaded with anti-TNF-alpha (infliximab) monoclonal antibodies to a partial-thickness burn will reduce inflammation within partially burned skin and prevent further progression to a full-thickness burn.	Alginates	64-72	tumor necrosis factor	Homo sapiens	99-108
34297530-5	2021	Moreover, the alginate-WHMP hydrogels upregulate the mitogen-activated protein kinase (MAPK) pathway, which in turn orchestrates several osteogenic markers, such as RUNX2 and OCN, in the encapsulated GMSCs.	Alginates	14-22	RUNX family transcription factor 2	Homo sapiens	165-170
34297530-5	2021	Moreover, the alginate-WHMP hydrogels upregulate the mitogen-activated protein kinase (MAPK) pathway, which in turn orchestrates several osteogenic markers, such as RUNX2 and OCN, in the encapsulated GMSCs.	Alginates	14-22	bone gamma-carboxyglutamate protein	Homo sapiens	175-178
34297530-6	2021	Concurrent coculture studies with human osteoclasts demonstrate that GMSCs encapsulated in alginate-WHMP hydrogels downregulate osteoclastic activity, potentially due to release of Mg2+ ions from the WHMPs along with secretion of osteoprotegerin from the GMSCs.	Alginates	91-99	TNF receptor superfamily member 11b	Homo sapiens	230-245
34216661-1	2021	This paper presents a new thermal sensitive hydrogel system based on cystamine-functionalised sodium alginate-g-pluronic F127 (ACP).	Alginates	94-109	CPAT1	Homo sapiens	127-130
34297017-9	2021	Furthermore, the expressions of angiogenesis-specific markers, PDGFR-beta, p-PI3K, p-Akt, and p-eNOS, were obviously increased in the PDGF-BB/SA/Dex/BMSCs group.	Alginates	142-144	platelet derived growth factor receptor alpha	Homo sapiens	63-73
34297017-9	2021	Furthermore, the expressions of angiogenesis-specific markers, PDGFR-beta, p-PI3K, p-Akt, and p-eNOS, were obviously increased in the PDGF-BB/SA/Dex/BMSCs group.	Alginates	142-144	AKT serine/threonine kinase 1	Homo sapiens	85-88
34297017-9	2021	Furthermore, the expressions of angiogenesis-specific markers, PDGFR-beta, p-PI3K, p-Akt, and p-eNOS, were obviously increased in the PDGF-BB/SA/Dex/BMSCs group.	Alginates	142-144	nitric oxide synthase 3	Homo sapiens	96-100
34297017-10	2021	In conclusion, the PDGF-BB/SA/Dex injectable hydrogels could accelerate BMSC-mediated skin wound healing by promoting angiogenesis via the activation of the PDGF-BB/PDGFR-beta-mediated PI3K/Akt/eNOS pathway, which may provide a new therapeutic strategy for stem cell therapy in wound healing.	Alginates	27-29	platelet derived growth factor receptor alpha	Homo sapiens	165-175
34297017-10	2021	In conclusion, the PDGF-BB/SA/Dex injectable hydrogels could accelerate BMSC-mediated skin wound healing by promoting angiogenesis via the activation of the PDGF-BB/PDGFR-beta-mediated PI3K/Akt/eNOS pathway, which may provide a new therapeutic strategy for stem cell therapy in wound healing.	Alginates	27-29	AKT serine/threonine kinase 1	Homo sapiens	190-193
34297017-10	2021	In conclusion, the PDGF-BB/SA/Dex injectable hydrogels could accelerate BMSC-mediated skin wound healing by promoting angiogenesis via the activation of the PDGF-BB/PDGFR-beta-mediated PI3K/Akt/eNOS pathway, which may provide a new therapeutic strategy for stem cell therapy in wound healing.	Alginates	27-29	nitric oxide synthase 3	Homo sapiens	194-198
34442609-7	2021	CONCLUSION: Our proposed alginate bead using the specific gravity-free method suggests that the screening of mutated ctKRAS DNA and miR-31-5 by liquid biopsy aids in identifying the patients, predicting a primary tumor, and monitoring in the early detection of a tumor.	Alginates	25-33	microRNA 31	Homo sapiens	132-138
34337208-6	2021	Here, we detail the formulation of a bioink consisting of mica pigments suspended in alginate as a new, vibrant art medium for 2D and 3D compositions.	Alginates	85-93	MHC class I polypeptide-related sequence A	Homo sapiens	58-62
34197049-0	2021	Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Produce Distinct Neural 3D In Vitro Models Depending on Alginate/Gellan Gum/Laminin Hydrogel Blend Properties.	Alginates	124-132	OTU deubiquitinase with linear linkage specificity	Homo sapiens	140-143
34452150-1	2021	The structure and biocompatibility analysis of a hydrogel based on cellulose nanofibers (CNFs) combined with alginate/pectin (A.CNF or P.CNF) and enriched with 1% or 5% 5-FU revealed more favorable properties for the cellular component when pectin was dispersed within CNFs.	Alginates	109-117	NPHS1 adhesion molecule, nephrin	Homo sapiens	128-131
34436110-3	2021	The aim of this study is to develop clinically viable alternatives to address the challenges of bone tissue regeneration in the OMF region by developing "dual network composites" (DNC"s) of calcium metaphosphate (CMP)-poly(vinyl alcohol) (PVA)/alginate with osteogenic ions: calcium, zinc and strontium.	Alginates	244-252	solute carrier family 25 member 19	Homo sapiens	180-183
34409038-4	2021	In this work we established a new in vitro cell culture system based on the microencapsulation of hiPSCs in small alginate/fibronectin beads and their differentiation to DA neurons.	Alginates	114-122	fibronectin 1	Homo sapiens	123-134
34174304-2	2021	In this regard, alginate as a natural polysaccharide was impregnated and modified with 2-hydroxy-5-nonylacetophenone oxime (Lix-84) and characterized using FT-IR, TGA/DTA and SEM-EDX.	Alginates	16-24	T-box transcription factor 1	Homo sapiens	163-166
34223593-1	2021	The concentration gradient arising from the migration of metal ions and organic ligands could transform alginate fibres into MOF tubes in an aqueous environment.	Alginates	104-112	lysine acetyltransferase 8	Homo sapiens	125-128
34197074-5	2021	Here, using a spin-coating method with thin films of alginate and SWCNTs, we demonstrate that a novel hydrogel platform can be created to investigate immobilized individual SWCNTs without significantly perturbing their optical properties as compared to solution-phase values.	Alginates	53-61	spindlin 1	Homo sapiens	14-18
34221812-0	2021	Grafted carrageenan: alginate gel beads for catalase enzyme covalent immobilization.	Alginates	21-29	catalase	Homo sapiens	44-52
34238938-0	2021	Silver incorporated into g-C3N4/Alginate as an efficient and heterogeneous catalyst for promoting click and A3 and KA2 coupling reaction.	Alginates	32-40	glutamate ionotropic receptor kainate type subunit 5	Homo sapiens	115-118
34229022-0	2021	Epicatechin gallate-loaded calcium alginate sponges promote diabetic wound healing through protecting against oxidative stress and modulation of immune response via PI3K/AKT/NFkappaB signaling pathway.	Alginates	27-43	AKT serine/threonine kinase 1	Rattus norvegicus	170-173
34202848-0	2021	Paclitaxel-Loaded Folate-Targeted Albumin-Alginate Nanoparticles Crosslinked with Ethylenediamine.	Alginates	42-50	albumin	Homo sapiens	34-41
34152142-4	2021	Moreover, SA decreased gut inflammation by reducing serum d-lactic acid (D-LA) and lipopolysaccharide (LPS) concentrations and downregulating toll-like receptor 4 (Tlr4) and mitogen-activated protein kinase (Mapk) pathway expression.	Alginates	10-12	glucuronidase, beta	Mus musculus	23-26
34152142-4	2021	Moreover, SA decreased gut inflammation by reducing serum d-lactic acid (D-LA) and lipopolysaccharide (LPS) concentrations and downregulating toll-like receptor 4 (Tlr4) and mitogen-activated protein kinase (Mapk) pathway expression.	Alginates	10-12	toll-like receptor 4	Mus musculus	142-162
34152142-4	2021	Moreover, SA decreased gut inflammation by reducing serum d-lactic acid (D-LA) and lipopolysaccharide (LPS) concentrations and downregulating toll-like receptor 4 (Tlr4) and mitogen-activated protein kinase (Mapk) pathway expression.	Alginates	10-12	toll-like receptor 4	Mus musculus	164-168
34152142-6	2021	In conclusion, our study provides a scientific basis for SA as a functional food in modulating gut microbiota and protecting against intestinal mucosal injury and indicates that SA has potential application for enhancing immunity.	Alginates	57-59	glucuronidase, beta	Mus musculus	95-98
34721597-0	2021	Effect of Lysophosphatidic Acid on the Vascular Endothelial Growth Factor Expression in Autotransplanted Mouse Ovaries Encapsulated in Sodium Alginate.	Alginates	135-150	vascular endothelial growth factor A	Mus musculus	39-73
34095615-1	2021	To prevent postoperative skin tumor recurrence and repair skin wound, a glucose oxidase (GOx)-loaded manganese silicate hollow nanospheres (MS HNSs)-incorporated alginate hydrogel (G/MS-SA) was constructed for starvation-photothermal therapy and skin tissue regeneration.	Alginates	162-170	hydroxyacid oxidase 1	Homo sapiens	72-87
34095615-1	2021	To prevent postoperative skin tumor recurrence and repair skin wound, a glucose oxidase (GOx)-loaded manganese silicate hollow nanospheres (MS HNSs)-incorporated alginate hydrogel (G/MS-SA) was constructed for starvation-photothermal therapy and skin tissue regeneration.	Alginates	162-170	hydroxyacid oxidase 1	Homo sapiens	89-92
34164502-12	2021	After 21 days of culture, the messenger RNA expression levels of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) were significantly higher in oocytes in fibroblast-alginate hydrogels than in those in alginate hydrogels (P<0.05).	Alginates	197-205	growth differentiation factor 9	Homo sapiens	65-96
34164502-12	2021	After 21 days of culture, the messenger RNA expression levels of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) were significantly higher in oocytes in fibroblast-alginate hydrogels than in those in alginate hydrogels (P<0.05).	Alginates	197-205	growth differentiation factor 9	Homo sapiens	98-102
34164502-12	2021	After 21 days of culture, the messenger RNA expression levels of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) were significantly higher in oocytes in fibroblast-alginate hydrogels than in those in alginate hydrogels (P<0.05).	Alginates	197-205	bone morphogenetic protein 15	Homo sapiens	108-137
34164502-12	2021	After 21 days of culture, the messenger RNA expression levels of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) were significantly higher in oocytes in fibroblast-alginate hydrogels than in those in alginate hydrogels (P<0.05).	Alginates	197-205	bone morphogenetic protein 15	Homo sapiens	139-144
34164502-12	2021	After 21 days of culture, the messenger RNA expression levels of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) were significantly higher in oocytes in fibroblast-alginate hydrogels than in those in alginate hydrogels (P<0.05).	Alginates	233-241	growth differentiation factor 9	Homo sapiens	65-96
34164502-12	2021	After 21 days of culture, the messenger RNA expression levels of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) were significantly higher in oocytes in fibroblast-alginate hydrogels than in those in alginate hydrogels (P<0.05).	Alginates	233-241	bone morphogenetic protein 15	Homo sapiens	108-137
34152142-0	2021	Sodium Alginate Modulates Immunity, Intestinal Mucosal Barrier Function, and Gut Microbiota in Cyclophosphamide-Induced Immunosuppressed BALB/c Mice.	Alginates	0-15	glucuronidase, beta	Mus musculus	77-80
34069622-6	2021	For multilayer composites with weak polyacid salts (ALG and HA), the crystallization of CS in the PEC layer is weaker, as reflected in the thermal degradation of these films.	Alginates	52-55	citrate synthase	Homo sapiens	88-90
34069622-7	2021	A high-temperature peak is recorded in the thermal decomposition of CS/HA and is absent in the case of CS/ALG.	Alginates	106-109	citrate synthase	Homo sapiens	103-105
34069622-8	2021	Dynamic mechanical analysis of the CS/ALG composite showed two glass transition temperatures close to those of the original polymers, indicating weak PEC formation.	Alginates	38-41	citrate synthase	Homo sapiens	35-37
34069622-10	2021	Thus, the effect of the PEC layer on the properties of the poly-layer composites decreases in the order CS/SEC > CS/HA > CS/ALG.	Alginates	124-127	citrate synthase	Homo sapiens	121-123
34067593-0	2021	Sustained Release of Bone Morphogenetic Protein-2 through Alginate Microbeads Enhances Bone Regeneration in Rabbit Tibial Metaphyseal Defect Model.	Alginates	58-66	bone morphogenetic protein 2	Homo sapiens	21-49
34067593-3	2021	In this study, BMP-2-encapsulated alginate microbeads (AM) were used to enhance bone regeneration.	Alginates	34-42	bone morphogenetic protein 2	Homo sapiens	15-20
35483853-5	2022	In addition, plasmid DNA encoding platelet-derived growth factor-B (PDGF-B) were complexed with polyethylenimine (PEI) to form cationic nanoparticles which were then adsorbed on anionic alginate fibers through electrostatic interaction.	Alginates	186-194	platelet derived growth factor subunit B	Homo sapiens	34-66
34083930-14	2021	Conclusion: PVA and alginate nanofibers can modulate obesity, reduce blood glucose levels, and reduce serum levels of insulin, ALT, ALP, GGT, creatinine, TNF-alpha, and IL-1beta in diabetic rats.	Alginates	20-28	gamma-glutamyltransferase 1	Rattus norvegicus	137-140
34083930-14	2021	Conclusion: PVA and alginate nanofibers can modulate obesity, reduce blood glucose levels, and reduce serum levels of insulin, ALT, ALP, GGT, creatinine, TNF-alpha, and IL-1beta in diabetic rats.	Alginates	20-28	tumor necrosis factor	Rattus norvegicus	154-163
34083930-14	2021	Conclusion: PVA and alginate nanofibers can modulate obesity, reduce blood glucose levels, and reduce serum levels of insulin, ALT, ALP, GGT, creatinine, TNF-alpha, and IL-1beta in diabetic rats.	Alginates	20-28	interleukin 1 alpha	Rattus norvegicus	169-177
35483853-5	2022	In addition, plasmid DNA encoding platelet-derived growth factor-B (PDGF-B) were complexed with polyethylenimine (PEI) to form cationic nanoparticles which were then adsorbed on anionic alginate fibers through electrostatic interaction.	Alginates	186-194	platelet derived growth factor subunit B	Homo sapiens	68-74
35169264-7	2022	Each species harbours a unique substrate-degradation potential along with predicted substrates conserved at the genus-level, e.g. alginate in NS5_F.	Alginates	130-138	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	142-145
35289080-2	2022	Present investigation is aimed to synthesize chitosan-sodium alginate (CS) nanocomposite using hydrothermally prepared zirconia nanoparticles.	Alginates	54-69	citrate synthase	Homo sapiens	71-73
35289080-8	2022	These studies explore that zirconia nanoparticles are suitable for biomedical applications while it is interacted with chitosan and sodium alginate (CS) due to their promising biocompatibility.	Alginates	132-147	citrate synthase	Homo sapiens	149-151
35421617-7	2022	Thus, injectable BG/sodium alginate (BG/SA) hydrogels loaded with MMP9-siNP can significantly accelerate the healing process of full-thickness excision wounds of diabetic rats by decreasing MMP-9 expression, improving collagen synthesis, and enhancing angiogenesis in the wounds, thereby demonstrating their great application potential in treating diabetic chronic wounds.	Alginates	20-35	matrix metallopeptidase 9	Rattus norvegicus	190-195
35489624-0	2022	In vitro culture of hematopoietic stem cell niche using angiopoietin-1-coupled alginate hydrogel.	Alginates	79-87	angiopoietin 1	Mus musculus	56-70
35489624-4	2022	Alginate hydrogel was thus modified with Ang1 as a synthetic ECM to mimic the HSC niche.	Alginates	0-8	angiopoietin 1	Mus musculus	41-45
35445677-0	2022	In vitro evidence of oncofetal antigen and TLR-9 agonist co-delivery by alginate nanovaccines for liver cancer immunotherapy.	Alginates	72-80	toll like receptor 9	Homo sapiens	43-48
35489624-5	2022	Long-term HSCs (CD34-, CD135-, and CD150+) were isolated from mouse femurs and cultured on Ang1-modified alginate hydrogel.	Alginates	105-113	angiopoietin 1	Mus musculus	91-95
35489624-7	2022	Ang1-coupled alginate gels were useful to provide a niche for HSC quiescence without a co-culture system.	Alginates	13-21	angiopoietin 1	Mus musculus	0-4
35445677-3	2022	Polyanionic alginate (ALG) and polycationic polyethyleneimine (PEI) were utilized to co-deliver a glypican-3 peptide antigen and an unmethylated cytosine-phosphate-guanine (CpG) adjuvant by electrostatic interactions.	Alginates	22-25	glypican 3	Homo sapiens	98-108
35523200-5	2022	In addition, sorption studies showed that a composite of dMOR-2 with calcium alginate (dMOR-2@CaA) is an excellent sorbent for Pb2+ and Cu2+ ions with capacities of 376 +- 15 and 117 +- 4 mg per gram of dMOR-2@CaA, respectively, while displaying the capability for simultaneous removal of various heavy metal ions in low initial concentrations and in the presence of large excesses of other cationic species.	Alginates	69-85	screw	Drosophila melanogaster	87-93
35622002-5	2022	Layer-by-layer coatings based on BMP-2-containing chitosan tripolyphosphate nanogel particles and negatively charged alginate showed a good sustainment of BMP-2 release from chemically modified polycaprolactone fiber mats.	Alginates	117-125	bone morphogenetic protein 2	Homo sapiens	155-160
35580812-7	2022	Interestingly, oral administration of hydrogel (chitosan/alginate)-embedding CBF-EGCG-NPs could not only retard progression and treat UC, but also modulate intestinal microbiota by increasing their overall diversity and richness and augmenting the abundance of beneficial bacteria (e.g., Firmicutes and Lactobacillaceae).	Alginates	57-65	CCAAT/enhancer binding protein zeta	Mus musculus	77-80
35523200-5	2022	In addition, sorption studies showed that a composite of dMOR-2 with calcium alginate (dMOR-2@CaA) is an excellent sorbent for Pb2+ and Cu2+ ions with capacities of 376 +- 15 and 117 +- 4 mg per gram of dMOR-2@CaA, respectively, while displaying the capability for simultaneous removal of various heavy metal ions in low initial concentrations and in the presence of large excesses of other cationic species.	Alginates	69-85	screw	Drosophila melanogaster	203-209
35481854-0	2022	Engineering cryoelectrospun elastin-alginate scaffolds to serve as stromal extracellular matrices.	Alginates	36-44	elastin	Homo sapiens	28-35
35373788-0	2022	Physical confinement in alginate cryogels determines macrophage polarization to a M2 phenotype by regulating a STAT-related mRNA transcription pathway.	Alginates	24-32	signal transducer and activator of transcription 1	Homo sapiens	111-115
35580307-6	2022	First, magnetic hydrogel was produced by a solution of alginate with magnetic nanoparticles in a bath of calcium chloride (5-15 mg mL-1) in order to achieve the external gelation and optimize the heating rate.	Alginates	55-63	L1 cell adhesion molecule	Mus musculus	131-135
35257727-1	2022	Sodium alginate/krill protein/polyacrylamide (SA/AKP/PAM) hydrogel with "covalent bond-ion complex-hydrogen bond" multi-network structure was prepared by covalent cross-linking and complexion ion crosslinking using SA, AKP, and acrylamide (AM) as raw materials.	Alginates	0-15	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	53-56
35626942-5	2022	The content of proinflammatory factor IL-6 of colon tissues in the sodium-alginate group (1.02 ng/mL) was lower (p < 0.05) than that in chitosan, curdlan-gum and konjac-gum groups (1.29, 1.31 and 1.31 ng/mL, respectively).	Alginates	67-82	interleukin 6	Mus musculus	38-42
35481352-6	2022	LL-37, insulin, lysozyme, and glucose oxidase were complexed with alginate, poly(styrenesulfonate), heparin, and poly(allylamine hydrochloride).	Alginates	66-74	insulin	Homo sapiens	7-14
35508533-0	2022	Designing a new alginate-fibrinogen biomaterial composite hydrogel for wound healing.	Alginates	16-24	fibrinogen beta chain	Homo sapiens	25-35
35508533-4	2022	Biophysical characterization showed that the interaction of fibrinogen and alginate was associated with minor changes in the secondary structure of the protein.	Alginates	75-83	fibrinogen beta chain	Homo sapiens	60-70
35218799-0	2022	Core-shell alginate beads as green reactor to synthesize grafted composite beads to efficiently boost single/co-adsorption of dyes and Pb(II).	Alginates	11-19	submaxillary gland androgen regulated protein 3B	Homo sapiens	135-141
35486294-4	2022	PROCEDURES: A time-stable material mimicking the MR properties of methemoglobin in IPH was created by doping agarose hydrogel with gadolinium and sodium alginate.	Alginates	146-161	hemoglobin subunit gamma 2	Homo sapiens	66-79
35172002-3	2022	The objective of the current study was to screen a set of 768 ToxCast chemicals in the VM7Luc estrogen receptor transactivation assay (ERTA) using the Alginate Immobilization of Metabolic Enzymes (AIME) hepatic metabolism method.	Alginates	151-159	estrogen receptor 1	Homo sapiens	94-111
35454488-1	2022	In order to prepare edible films with outstanding antimicrobials and antioxidants utilized in applications of food and pharmaceutics, in this study, effects of surfactants on zein cast films for simultaneous delivery of lysozyme (LY) and ascorbic acid (AA) were investigated, where sodium alginate (SA), soy lecithin (SL), and Pluronic f-68 (PF-68) were selected as surfactants.	Alginates	282-297	lysozyme	Homo sapiens	220-228
35454488-1	2022	In order to prepare edible films with outstanding antimicrobials and antioxidants utilized in applications of food and pharmaceutics, in this study, effects of surfactants on zein cast films for simultaneous delivery of lysozyme (LY) and ascorbic acid (AA) were investigated, where sodium alginate (SA), soy lecithin (SL), and Pluronic f-68 (PF-68) were selected as surfactants.	Alginates	299-301	lysozyme	Homo sapiens	220-228
35387972-2	2022	Here, we report a biocompatible alginate-based hydrogel loaded with Pexidartinib (PLX)-encapsulated nanoparticles that gradually release PLX at the tumor site to block colony-stimulating factor 1 receptors (CSF1R) for depleting TAMs.	Alginates	32-40	colony stimulating factor 1 receptor	Sus scrofa	168-205
35365684-5	2022	In this study, we engineered a mucus-like hydrogel Consisting of a mixed alginate-mucin (ALG-MUC) hydrogel network by using low concentration calcium chloride (CaCl2) as crosslinker.	Alginates	73-81	LOC100508689	Homo sapiens	82-87
35388027-10	2022	The latter showed favorable controlled, yet complete release of MET at pH 6.8 and was loaded into alginate beads.	Alginates	98-106	SAFB like transcription modulator	Homo sapiens	64-67
35432359-0	2022	Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice.	Alginates	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	109-113
35533377-3	2022	Herein, on the basis of a conventional gelation strategy of sodium alginate combined with metal ions, Ga3+ has been innovatively given a dual role in a dual-cross-linked hydrogel.	Alginates	60-75	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	102-105
35258916-4	2022	During the mechanical stirring process, the released Ga3+ can cross-link with sodium alginate to form microgels covering the surface of LM droplets, which exhibits shear-thinning performance due to the formation and rupture of hydrogen bonds under different stress conditions, making the LMM ink possess excellent printability and superior adhesion to various substrates.	Alginates	78-93	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	53-56
35254348-5	2022	This complex was successfully immobilized on an alginate-functionalized layered double hydroxide (dLDH) nanosheet via electrostatic interactions.	Alginates	48-56	Lactate dehydrogenase	Drosophila melanogaster	98-102
35085730-7	2022	The ATR-FTIR and MD simulation revealed H-bonding between the alginate and naproxen sodium at 3500-3200 cm-1 with a RMSD of ~2.8 A and binding free energy DeltaGpred (GB) = -10.93 kcal/mol.	Alginates	62-70	ATR serine/threonine kinase	Rattus norvegicus	4-7
35211369-0	2022	Antioxidant-biocompatible and stable catalase-based gelatin-alginate hydrogel scaffold with thermal wound healing capability: immobilization and delivery approach.	Alginates	60-68	catalase	Homo sapiens	37-45
35041888-0	2022	Alginate-enabled green synthesis of S/Ag1.93S nanoparticles, their photothermal property and in-vitro assessment of their anti-skin-cancer effects augmented by a NIR laser.	Alginates	0-8	thioredoxin domain containing 12	Homo sapiens	38-41
35330841-6	2022	At present, we have designed a sustained-release system of bFGF (called ALG-bFGF) using sodium alginate hydrogel, which is able to load large amounts of bFGF and suitable for in situ administration of bFGF in vivo.	Alginates	88-103	fibroblast growth factor 2	Mus musculus	59-63
35330841-6	2022	At present, we have designed a sustained-release system of bFGF (called ALG-bFGF) using sodium alginate hydrogel, which is able to load large amounts of bFGF and suitable for in situ administration of bFGF in vivo.	Alginates	88-103	fibroblast growth factor 2	Mus musculus	72-80
35330841-6	2022	At present, we have designed a sustained-release system of bFGF (called ALG-bFGF) using sodium alginate hydrogel, which is able to load large amounts of bFGF and suitable for in situ administration of bFGF in vivo.	Alginates	88-103	fibroblast growth factor 2	Mus musculus	153-157
35330841-6	2022	At present, we have designed a sustained-release system of bFGF (called ALG-bFGF) using sodium alginate hydrogel, which is able to load large amounts of bFGF and suitable for in situ administration of bFGF in vivo.	Alginates	88-103	fibroblast growth factor 2	Mus musculus	201-205
35234107-2	2022	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.	Alginates	44-60	chorionic somatomammotropin hormone 2	Homo sapiens	135-142
35234107-2	2022	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.	Alginates	94-110	chorionic somatomammotropin hormone 2	Homo sapiens	135-142
35234107-2	2022	In this work, groundnut husk biochar (GHB), calcium alginate (CA), and groundnut husk biochar/calcium alginate novel composites (%10) (CA-GHB1) and (% 20) (CA-GHB2) are synthesized and characterized using BET, SEM, EDX, FTIR, TGA.	Alginates	94-110	delta/notch like EGF repeat containing	Homo sapiens	205-208
35275912-6	2022	Alginate encapsulation is frequently used with probiotics to increase persistence of bacteria within the gastrointestinal system, and was used to encapsulate the highly attenuated LVS O-antigen mutant WbtIG191V.	Alginates	0-8	lacking vigorous sperm	Mus musculus	180-183
35323276-0	2022	PCL/Sodium-Alginate Based 3D-Printed Dual Drug Delivery System with Antibacterial Activity for Osteomyelitis Therapy.	Alginates	4-19	PHD finger protein 1	Homo sapiens	0-3
35323276-5	2022	Thus, in this study, we developed a dual-drug-releasing PCL/sodium-alginate-based 3D-printed scaffold to effectively treat osteomyelitis by removing the biofilm.	Alginates	60-75	PHD finger protein 1	Homo sapiens	56-59
35157940-3	2022	The surface of the dual-targeting nanosystem is composed of MUC1 specific aptamer incorporated alginate (MUC1 aptamer-alginate) and T22-NLS peptide with T22 sequence targeting CXCR4; the core of the nanosystem consists of protamine complexed with CRISPR-Cas9 plasmid.	Alginates	95-103	mucin 1, cell surface associated	Homo sapiens	60-64
35074553-4	2022	IFNgamma-loaded heparin-coated beads were included in injectable in situ crosslinking alginate hydrogels, providing a 3D microenvironment that ensured continuous inflammatory licensing, cell persistence and implant retrievability.	Alginates	86-94	interferon gamma	Mus musculus	0-8
35581061-1	2022	Addressing osteochondral defects, the objective of current study was to synthesize bilayered hydrogel, where the cartilage layer was formed by alginate (Alg)-polyacrylamide (PAAm) with and without the addition of TGF-beta3 and bone layer by laponite XLS/Alg-PAAm and characterize by in vitro and in vivo experiments.	Alginates	153-156	transforming growth factor beta 3	Homo sapiens	213-222
35203648-4	2022	Alginate microbeads were fabricated by dropping a 2% (w/v) alginate solution containing TMSCs into a 5% CaCl2 solution and then differentiated into parathyroid-like cells using activin A and sonic hedgehog for 7 days.	Alginates	0-8	inhibin subunit beta A	Rattus norvegicus	177-186
35200665-1	2022	Chitosan/alginate nanoparticles (DG1-NPs and DG1/Cur-NPs) aiming to enhance the oral antithrombotic activity of clam heparinoid DG1 were prepared by ionotropic pre-gelation.	Alginates	9-17	desmoglein 1 alpha	Mus musculus	33-36
35200665-1	2022	Chitosan/alginate nanoparticles (DG1-NPs and DG1/Cur-NPs) aiming to enhance the oral antithrombotic activity of clam heparinoid DG1 were prepared by ionotropic pre-gelation.	Alginates	9-17	desmoglein 1 alpha	Mus musculus	45-48
35200665-1	2022	Chitosan/alginate nanoparticles (DG1-NPs and DG1/Cur-NPs) aiming to enhance the oral antithrombotic activity of clam heparinoid DG1 were prepared by ionotropic pre-gelation.	Alginates	9-17	desmoglein 1 alpha	Mus musculus	128-131
35200665-3	2022	Results indicate that chitosan and alginate can be used as polymer matrices to encapsulate DG1, and nanoparticle characteristics depend on the preparation parameters.	Alginates	35-43	desmoglein 1 alpha	Mus musculus	91-94
35200665-8	2022	Therefore, the chitosan/alginate nanoparticles enhanced the oral antithrombotic activity of DG1, but curcumin did not further enhance this effect.	Alginates	24-32	desmoglein 1 alpha	Mus musculus	92-95
35323458-7	2022	AlyM2 is a PL6 lyase with low sequence identity (<=28.3%) to the characterized alginate lyases and may adopt a distinct catalytic mechanism from the other PL6 alginate lyases based on sequence alignment.	Alginates	159-167	transmembrane protein 115	Homo sapiens	155-158
35323455-7	2022	An in vitro drug release study suggested successful nanoparticle surface modification by ALG and PEG, showing gastric fluid stability (4 h) and a 96 h sustained OVA release in intestinal fluid, with the nanoparticles maintaining their conformational stability (SDS-PAGE and CD analyses) after release in the intestinal fluid.	Alginates	89-92	ovalbumin	Sus scrofa	161-164
35170632-11	2022	Carboplatin-loaded poly(lactide-co-glycolide) or sodium alginate-poly(lactide-co-glycolide) exposure inhibited proliferating cell nuclear antigen expression in Y79 cells on day 3.	Alginates	49-64	proliferating cell nuclear antigen	Homo sapiens	111-145
35136126-4	2022	The best performance was observed for GO/SA-g-poly(AAm-co-GMA) sample indicating better stabilizing electrostatic attractions between PersiXyn9 and reinforced SA-based hydrogel.	Alginates	159-161	S-antigen visual arrestin	Homo sapiens	41-45
35034580-0	2022	The adsorption property of in-situ synthesis of MOF in alginate gel for ofloxacin in the wastewater.	Alginates	55-63	lysine acetyltransferase 8	Homo sapiens	48-51
35034580-2	2022	In-situ MOF synthesis in alginate gel is a good way to fabricate an MOF composite for many applications, which is different from blending MOF particles with polymers.	Alginates	25-33	lysine acetyltransferase 8	Homo sapiens	8-11
35034580-2	2022	In-situ MOF synthesis in alginate gel is a good way to fabricate an MOF composite for many applications, which is different from blending MOF particles with polymers.	Alginates	25-33	lysine acetyltransferase 8	Homo sapiens	68-71
35157940-3	2022	The surface of the dual-targeting nanosystem is composed of MUC1 specific aptamer incorporated alginate (MUC1 aptamer-alginate) and T22-NLS peptide with T22 sequence targeting CXCR4; the core of the nanosystem consists of protamine complexed with CRISPR-Cas9 plasmid.	Alginates	118-126	mucin 1, cell surface associated	Homo sapiens	60-64
35157940-3	2022	The surface of the dual-targeting nanosystem is composed of MUC1 specific aptamer incorporated alginate (MUC1 aptamer-alginate) and T22-NLS peptide with T22 sequence targeting CXCR4; the core of the nanosystem consists of protamine complexed with CRISPR-Cas9 plasmid.	Alginates	118-126	mucin 1, cell surface associated	Homo sapiens	105-109
34875631-2	2022	In this study, an advanced hybrid hydrogel ink was developed, a mixture of thermogelling diblock copolymer, alginate and clay i.e. Laponite XLG.	Alginates	108-116	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	140-143
35160907-4	2022	The characterization of the newly synthetized calcium alginate-lignin composite was performed using ATR/FT-IR, SEM, EDX, OM, AFM, XRD, BET, sieve analysis and pHpzc measurements.	Alginates	46-62	ATR serine/threonine kinase	Homo sapiens	100-103
34883477-3	2022	To this end alginate sulfate, a sulfated glycosaminoglycan (sGAG) mimic, was used to functionalize porous alginate-based scaffolds and to support the sustained release of transforming growth factor-beta3 (TGF-beta3).	Alginates	106-114	transforming growth factor beta 3	Homo sapiens	171-203
35163172-0	2022	Chitosan/Alginate Hydrogel Dressing Loaded FGF/VE-Cadherin to Accelerate Full-Thickness Skin Regeneration and More Normal Skin Repairs.	Alginates	9-17	cadherin 5	Homo sapiens	47-58
35200618-5	2022	In the present study, we used alginate, a natural polysaccharide extracted from a brown algae Bifurcaria bifurcata, to activate date palm defenses, which involve phenylalanine ammonia-lyase (PAL), a key enzyme of phenylpropanoid metabolism.	Alginates	30-38	phenylalanine ammonia-lyase	Phoenix dactylifera	162-189
35200618-5	2022	In the present study, we used alginate, a natural polysaccharide extracted from a brown algae Bifurcaria bifurcata, to activate date palm defenses, which involve phenylalanine ammonia-lyase (PAL), a key enzyme of phenylpropanoid metabolism.	Alginates	30-38	phenylalanine ammonia-lyase	Phoenix dactylifera	191-194
35200618-6	2022	The results obtained showed that at low concentration (1 g L-1), alginate stimulated PAL activity in date palm roots 5 times more compared to the negative control (water-treated) after 24 h following treatment and 2.5 times more compared to the laminarin used as a positive stimulator of plant natural defenses (positive control of induction).	Alginates	65-73	phenylalanine ammonia-lyase	Phoenix dactylifera	85-88
35200618-8	2022	The results showed that, generally, the PAL gene tested and the genes encoding enzymes involved in early oxidative events (SOD and LOX) were overexpressed in the alginate-treated plants compared to their levels in the positive and negative controls.	Alginates	162-170	phenylalanine ammonia-lyase	Phoenix dactylifera	40-43
35261646-7	2022	Anti-inflammation results demonstrated that the NAL-SA-MVs could reduce the pro-inflammation factors (iNOS, TNF-alpha, IL-1beta, IL-6) and increase the expression of anti-inflammation factors (IL-10) at the cell and animal level.	Alginates	52-54	tumor necrosis factor	Mus musculus	108-117
35517877-0	2022	Fibronectin within Sodium Alginate Microcapsules Improved Osteogenic Differentiation of BMMSCs in Dose Dependent Manner by Targeting SP7, OCN, CDK1, ZBTB16, and Twist1 Expression.	Alginates	19-34	fibronectin 1	Homo sapiens	0-11
35517877-0	2022	Fibronectin within Sodium Alginate Microcapsules Improved Osteogenic Differentiation of BMMSCs in Dose Dependent Manner by Targeting SP7, OCN, CDK1, ZBTB16, and Twist1 Expression.	Alginates	19-34	Sp7 transcription factor	Homo sapiens	133-136
35517877-0	2022	Fibronectin within Sodium Alginate Microcapsules Improved Osteogenic Differentiation of BMMSCs in Dose Dependent Manner by Targeting SP7, OCN, CDK1, ZBTB16, and Twist1 Expression.	Alginates	19-34	bone gamma-carboxyglutamate protein	Homo sapiens	138-141
35517877-0	2022	Fibronectin within Sodium Alginate Microcapsules Improved Osteogenic Differentiation of BMMSCs in Dose Dependent Manner by Targeting SP7, OCN, CDK1, ZBTB16, and Twist1 Expression.	Alginates	19-34	cyclin dependent kinase 1	Homo sapiens	143-147
35517877-0	2022	Fibronectin within Sodium Alginate Microcapsules Improved Osteogenic Differentiation of BMMSCs in Dose Dependent Manner by Targeting SP7, OCN, CDK1, ZBTB16, and Twist1 Expression.	Alginates	19-34	zinc finger and BTB domain containing 16	Homo sapiens	149-155
35517877-0	2022	Fibronectin within Sodium Alginate Microcapsules Improved Osteogenic Differentiation of BMMSCs in Dose Dependent Manner by Targeting SP7, OCN, CDK1, ZBTB16, and Twist1 Expression.	Alginates	19-34	twist family bHLH transcription factor 1	Homo sapiens	161-167
35261646-7	2022	Anti-inflammation results demonstrated that the NAL-SA-MVs could reduce the pro-inflammation factors (iNOS, TNF-alpha, IL-1beta, IL-6) and increase the expression of anti-inflammation factors (IL-10) at the cell and animal level.	Alginates	52-54	interleukin 1 alpha	Mus musculus	119-127
35261646-7	2022	Anti-inflammation results demonstrated that the NAL-SA-MVs could reduce the pro-inflammation factors (iNOS, TNF-alpha, IL-1beta, IL-6) and increase the expression of anti-inflammation factors (IL-10) at the cell and animal level.	Alginates	52-54	interleukin 6	Mus musculus	129-133
35261646-7	2022	Anti-inflammation results demonstrated that the NAL-SA-MVs could reduce the pro-inflammation factors (iNOS, TNF-alpha, IL-1beta, IL-6) and increase the expression of anti-inflammation factors (IL-10) at the cell and animal level.	Alginates	52-54	interleukin 10	Mus musculus	193-198
6347140-3	1983	The efficiency of insulin encapsulation with crystalline insulin declined as the concentration in the sodium alginate mixture increased.	Alginates	102-117	insulin	Homo sapiens	18-25
22358627-0	1989	Production of erythropoietin by BHK cells growing on the microcarriers trapped in alginate gel beads.	Alginates	82-90	erythropoietin	Mesocricetus auratus	14-28
18584651-0	1988	Retention of insulin in alginate gel beads.	Alginates	24-32	insulin	Homo sapiens	13-20
3064828-3	1988	The release HSS was not observed when hepatocytes were microencapsulated in an alginate matrix.	Alginates	79-87	growth factor, augmenter of liver regeneration	Homo sapiens	12-15
3280940-1	1988	This paper describes a new formulation for triggered delivery of insulin which consisted of magnetic particles dispersed in alginate spheres.	Alginates	124-132	insulin	Homo sapiens	65-72
6358994-3	1983	Alginate impression material was used during one of the surgical procedures to aid in defining the margins of the lesion.	Alginates	0-8	activation induced cytidine deaminase	Homo sapiens	79-82
24234084-1	1982	The enzyme Beta-galactosidase was coimmobilized with the yeastSaccharomyces cerevisiae in alginate.	Alginates	90-98	galactosidase beta 1	Homo sapiens	11-29
343247-7	1978	CA-37 is, among the 3 studied alginates, the one which gave the worst results with regard to the ease of manipulation and compatibility with Vel Mix Stone.	Alginates	30-39	Mix paired-like homeobox	Homo sapiens	145-148
13727961-0	1961	[Alginate--skimmed milk mixture as an aid in obesity].	Alginates	1-9	activation induced cytidine deaminase	Homo sapiens	38-41
33910718-2	2021	Alginate-cellulose nanofibers (A-CNF) formulations with CNF amounts up to 5 wt% were developed and rheologically characterized to evaluate their printability.	Alginates	0-8	NPHS1 adhesion molecule, nephrin	Homo sapiens	33-36
33836362-2	2021	To solve the high viscosity-related problems while retaining its physiological properties, four partially degraded alginate products (PDA1-4) with molecular weight of 1.05-0.40 x 105 g mol-1 and intrinsic viscosity of 170.9-38.9 mL g-1 were enzymatically prepared and characterized.	Alginates	115-123	PDA1	Homo sapiens	134-140
33910718-2	2021	Alginate-cellulose nanofibers (A-CNF) formulations with CNF amounts up to 5 wt% were developed and rheologically characterized to evaluate their printability.	Alginates	0-8	NPHS1 adhesion molecule, nephrin	Homo sapiens	56-59
33831760-3	2021	SA@AM showed a size of 15-22 nm with 6.85 emu g-1 of magnetization value, exhibiting a high adsorption capacity on Pb(II) ions representing a common heavy metal pollutant, with a maximum adsorption capacity of 105.8 mg g-1.	Alginates	0-2	submaxillary gland androgen regulated protein 3B	Homo sapiens	115-121
33831760-4	2021	The Langmuir isotherm adsorption fits the adsorption curve, indicating uniform adsorption of Pb(II) on the SA@AM surfaces.	Alginates	107-109	submaxillary gland androgen regulated protein 3B	Homo sapiens	93-99
33831760-5	2021	Repeated adsorption desorption experiments showed that the removal ratio of Pb(II) by SA@AM was more than 76%, illustrating improved regeneration performance.	Alginates	86-88	submaxillary gland androgen regulated protein 3B	Homo sapiens	76-82
33836438-5	2021	Meanwhile, SDP-1 was immobilized on sodium alginate, and the capability of efficiently phenol degradation of free cells and immobilized SDP-1 were evaluated.	Alginates	36-51	mitogen-activated protein kinase tyrosine protein phosphatase SDP1	Saccharomyces cerevisiae S288C	11-16
32396763-4	2021	The Sodium alginate grafted acrylic acid (SA-g-AA) conjugated with Riboflavin (RB) was coated over MLV by O/W emulsion method followed by ionotropic gelation.	Alginates	4-19	S-antigen visual arrestin	Homo sapiens	42-46
33737187-7	2021	The biological assays show that the alginate/poloxamer hydrogels induce proliferation of human keratinocyte and have an anti-inflammatory effect on lipopolysaccharides (LPS)-activated keratinocytes by inhibiting the extracellular signal-regulated kinases (ERK)/ nuclear factor (NF)-kB/ tumor necrosis factor (TNF)-alpha signalling pathway.	Alginates	36-44	tumor necrosis factor	Homo sapiens	286-319
33652050-0	2021	Xanthate-modified alginates for the removal of Pb(II) and Ni(II) from aqueous solutions.	Alginates	18-27	submaxillary gland androgen regulated protein 3B	Homo sapiens	47-53
33736577-7	2021	The compacted AL film containing 2 mg ET (1 x 1 cm) exhibited rapid absorption (> 19 ng/mL at 0.5 h), maintained an effective plasma level (> 7 ng/mL) for a long time period (0.5 - 4 h), and had an adequate plasma concentration-time profile with a smaller standard error (< 15.3 ng/mL).	Alginates	14-16	major facilitator superfamily domain containing 11	Homo sapiens	38-40
34019920-1	2021	The purpose of this study was to further improve the physiochemical stability of the chitosan (CS) particle-stabilized Pickering emulsion by coating with sodium alginate (SA).	Alginates	154-169	citrate synthase	Homo sapiens	95-97
34019920-1	2021	The purpose of this study was to further improve the physiochemical stability of the chitosan (CS) particle-stabilized Pickering emulsion by coating with sodium alginate (SA).	Alginates	154-169	acyl-CoA synthetase medium chain family member 3	Homo sapiens	171-173
33652050-3	2021	In this context, this work is focused on the application of xanthate-modified alginates for the removal of Pb(II) and Ni(II) from aqueous solutions.	Alginates	78-87	submaxillary gland androgen regulated protein 3B	Homo sapiens	107-113
33964114-0	2021	Property modelling of lysozyme-crosslinker-alginate complexes using latent variable methods.	Alginates	43-51	lysozyme	Homo sapiens	22-30
34023604-8	2021	Therefore, the immobilization of bacteria consortium by sodium alginate-biochar enhanced the biodegradation of PCB 118, which will provide new insights into functional microorganisms" actual application for PCB restoration.	Alginates	56-71	pyruvate carboxylase	Homo sapiens	111-114
32969286-6	2021	The liver-specific functions, such as urea and albumin synthesis, and CYP1A2 and CYP3A4 activities from encapsulated cells were increased in the HA-SA-CS microcapsules compared to the SA-CS microcapsules.	Alginates	148-150	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	70-76
34025576-8	2021	Re-aggregated MACS sorted cells were encapsulated in microspheres made of alginate modified to reduce foreign body reaction.	Alginates	74-82	myristoylated alanine rich protein kinase C substrate	Mus musculus	14-18
32969286-6	2021	The liver-specific functions, such as urea and albumin synthesis, and CYP1A2 and CYP3A4 activities from encapsulated cells were increased in the HA-SA-CS microcapsules compared to the SA-CS microcapsules.	Alginates	148-150	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	81-87
33683250-4	2021	We demonstrate the loading of bovine serum albumin (BSA) in the sodium alginate phase and ibuprofen in the polylactic acid (PLA) phase, respectively.	Alginates	64-79	albumin	Homo sapiens	37-50
33947577-4	2021	To fabricate an immunomodulatory Ti implant, alginate/chitosan multilayer films were fabricated on the surface of titania nanotubes (TNTs) to control the release of an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work.	Alginates	45-53	interleukin 4	Rattus norvegicus	195-213
33621568-0	2021	Alginate/gelatin encapsulation promotes NK cells differentiation potential of bone marrow resident C-kit+ hematopoietic stem cells.	Alginates	0-8	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	99-104
33621568-3	2021	The present study was conducted to investigate the effect of alginate-gelatin encapsulation on NK cell differentiation potential of C-kit+ cells.	Alginates	61-69	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	132-137
33927974-4	2021	In this study, enzyme immobilization of glucose oxidase (GOx) on filter paper were examined using three polysaccharides such as chitosan, sodium alginate and dextran for entrapment efficiency, activity and stability of the immobilized enzyme.	Alginates	138-153	hydroxyacid oxidase 1	Homo sapiens	40-55
33927974-4	2021	In this study, enzyme immobilization of glucose oxidase (GOx) on filter paper were examined using three polysaccharides such as chitosan, sodium alginate and dextran for entrapment efficiency, activity and stability of the immobilized enzyme.	Alginates	138-153	hydroxyacid oxidase 1	Homo sapiens	57-60
33734514-3	2021	Here, the benefits of delivering a recombinant adeno-associated virus (rAAV) vector coding for the human insulin-like growth factor I (IGF-I) via an alginate hydrogel (IGF-I/AlgPH155) to enhance repair of full-thickness chondral defects following microfracture surgery after one year in minipigs versus control (lacZ/AlgPH155) treatment are reported.	Alginates	149-157	insulin like growth factor 1	Homo sapiens	105-133
33734514-3	2021	Here, the benefits of delivering a recombinant adeno-associated virus (rAAV) vector coding for the human insulin-like growth factor I (IGF-I) via an alginate hydrogel (IGF-I/AlgPH155) to enhance repair of full-thickness chondral defects following microfracture surgery after one year in minipigs versus control (lacZ/AlgPH155) treatment are reported.	Alginates	149-157	insulin like growth factor 1	Homo sapiens	135-140
33734514-3	2021	Here, the benefits of delivering a recombinant adeno-associated virus (rAAV) vector coding for the human insulin-like growth factor I (IGF-I) via an alginate hydrogel (IGF-I/AlgPH155) to enhance repair of full-thickness chondral defects following microfracture surgery after one year in minipigs versus control (lacZ/AlgPH155) treatment are reported.	Alginates	149-157	insulin like growth factor 1	Homo sapiens	168-173
33029736-2	2021	Here, we developed a novel strategy for repairing peripheral nerve injury by gold nanoparticles (AuNPs) and brain-derived neurotrophic factor (BDNF)-encapsulated chitosan in laminin-coated nanofiber of Poly(l-lactide-co-glycolide) (PLGA) conduit and transplantation of rat adipose-derived stem cells (r-ADSCs) suspended in alginate.	Alginates	323-331	brain-derived neurotrophic factor	Rattus norvegicus	108-141
33029736-2	2021	Here, we developed a novel strategy for repairing peripheral nerve injury by gold nanoparticles (AuNPs) and brain-derived neurotrophic factor (BDNF)-encapsulated chitosan in laminin-coated nanofiber of Poly(l-lactide-co-glycolide) (PLGA) conduit and transplantation of rat adipose-derived stem cells (r-ADSCs) suspended in alginate.	Alginates	323-331	brain-derived neurotrophic factor	Rattus norvegicus	143-147
33923314-0	2021	Synthesis of Eco-Friendly Biopolymer, Alginate-Chitosan Composite to Adsorb the Heavy Metals, Cd(II) and Pb(II) from Contaminated Effluents.	Alginates	38-46	submaxillary gland androgen regulated protein 3B	Homo sapiens	94-111
33924233-2	2021	The aim of this work is to shed light on the role played by chia oil in the technological and structural properties of EGs made from soy protein isolates (SPI) and alginate.	Alginates	164-172	chitinase acidic	Homo sapiens	60-64
33581203-6	2021	In vitro stimulation of splenocytes from mice vaccinated with alginate-chitosan-encapsulated KLM-gamma resulted in lymphocyte proliferation, increase of proportion of memory CD4+ and CD8+ T cell and production of IL-10 and IFN-gamma.	Alginates	62-70	CD4 antigen	Mus musculus	174-177
33581203-6	2021	In vitro stimulation of splenocytes from mice vaccinated with alginate-chitosan-encapsulated KLM-gamma resulted in lymphocyte proliferation, increase of proportion of memory CD4+ and CD8+ T cell and production of IL-10 and IFN-gamma.	Alginates	62-70	interleukin 10	Mus musculus	213-218
33581203-6	2021	In vitro stimulation of splenocytes from mice vaccinated with alginate-chitosan-encapsulated KLM-gamma resulted in lymphocyte proliferation, increase of proportion of memory CD4+ and CD8+ T cell and production of IL-10 and IFN-gamma.	Alginates	62-70	interferon gamma	Mus musculus	223-232
33581204-0	2021	Efficacy of treated sodium alginate and activated carbon fibre for Pb(II) adsorption.	Alginates	20-35	submaxillary gland androgen regulated protein 3B	Homo sapiens	67-73
33581204-1	2021	Efficacy of treated sodium alginate (TSA) and activated carbon fibre (ACF) for aqueous Pb(II) uptake was comparatively investigated.	Alginates	20-35	submaxillary gland androgen regulated protein 3B	Homo sapiens	87-93
33840091-7	2021	Under the right gelation pH (pH 4), the extension of gelation time from 1 to 12 h resulted in an increase in alginate-Ca2+ crosslinkings, thus strengthening the microcapsules.	Alginates	109-117	prolyl 4-hydroxylase, transmembrane	Homo sapiens	29-33
33838351-0	2021	Incorporation of VEGF-and bFGF-loaded alginate oxide particles in acellular collagen-alginate composite hydrogel to promote angiogenesis.	Alginates	38-46	fibroblast growth factor 2	Homo sapiens	26-30
33838351-3	2021	In the present study, we introduced an alginate oxide particle in acellular collagen-alginate composite hydrogel platform for the immobilization and controlled release of VEGF and bFGF to promote angiogenesis.	Alginates	39-47	vascular endothelial growth factor A	Homo sapiens	171-175
33838351-3	2021	In the present study, we introduced an alginate oxide particle in acellular collagen-alginate composite hydrogel platform for the immobilization and controlled release of VEGF and bFGF to promote angiogenesis.	Alginates	39-47	fibroblast growth factor 2	Homo sapiens	180-184
33543521-4	2021	A double-crosslinked alginate-based hydrogel with tantalum nanopowder (DAT) that exploits the synergistic effect of covalent crosslinking by visible-light irradiation and ionic crosslinking using Ca2+ , which is present in the blood, is developed in this study.	Alginates	21-29	solute carrier family 6 member 3	Homo sapiens	71-74
33345720-0	2021	A core-shell structured alginate hydrogel beads with tunable thickness of Carboxymethyl cellulose coating for pH responsive drug delivery.	Alginates	24-32	phenylalanine hydroxylase	Homo sapiens	110-112
33345720-1	2021	pH-responsive core-shell structured composite hydrogel beads, composed of a alginate (ALG) core coated with carboxymethyl cellulose (CMC) shell (ALG@CMC), were prepared by using in-situ gel preparation technology as a drug delivery system.	Alginates	76-84	phenylalanine hydroxylase	Homo sapiens	0-2
33345720-1	2021	pH-responsive core-shell structured composite hydrogel beads, composed of a alginate (ALG) core coated with carboxymethyl cellulose (CMC) shell (ALG@CMC), were prepared by using in-situ gel preparation technology as a drug delivery system.	Alginates	86-89	phenylalanine hydroxylase	Homo sapiens	0-2
33345720-1	2021	pH-responsive core-shell structured composite hydrogel beads, composed of a alginate (ALG) core coated with carboxymethyl cellulose (CMC) shell (ALG@CMC), were prepared by using in-situ gel preparation technology as a drug delivery system.	Alginates	145-148	phenylalanine hydroxylase	Homo sapiens	0-2
33345720-6	2021	The swelling and drug release behaviors revealed that the swelling and drug release rate of ALG@CMC beads were obviously slower than that of simple-ALG and both have significant pH responsiveness.	Alginates	92-95	phenylalanine hydroxylase	Homo sapiens	178-180
33898275-12	2021	Chitosan, carboxymethyl cellulose, alginate and lignin based nanocomposites have demonstrated better adsorption activities due to great physical and chemical properties for the chelation of heavy metals such as Cd2+, Pb2+ and Zn2+ from water and also higher regeneration with various eluents after several desorption-adsorption cycles.	Alginates	35-43	CD2 molecule	Homo sapiens	211-214
33483016-3	2021	To overcome these problems, a nanoformulation was developed using chitosan/alginate nanoparticles (CANPs) under the optimal condition as previously derived by statistical optimization.	Alginates	75-83	calpain small subunit 1	Homo sapiens	99-104
33733622-0	2021	Heparin-modified alginate microspheres enhance neovessel formation in hiPSC-derived endothelial cells and heterocellular in vitro models by controlled release of vascular endothelial growth factor.	Alginates	17-25	vascular endothelial growth factor A	Homo sapiens	162-196
33559717-3	2021	In this study, we used a novel biomaterial based on calcium-crosslinked alginate-encapsulated bacteria to precipitate Cd2+ in polluted water.	Alginates	72-80	CD2 molecule	Homo sapiens	118-121
33733622-3	2021	Sulfate and heparin moieties are covalently coupled to alginate, and alginate microspheres are produced and used as local delivery depots for vascular endothelial growth factor (VEGF).	Alginates	69-77	vascular endothelial growth factor A	Homo sapiens	142-176
33733622-3	2021	Sulfate and heparin moieties are covalently coupled to alginate, and alginate microspheres are produced and used as local delivery depots for vascular endothelial growth factor (VEGF).	Alginates	69-77	vascular endothelial growth factor A	Homo sapiens	178-182
33733622-4	2021	Release of VEGF from sulfate-alginate and heparin-alginate bulk hydrogels and microspheres was sustained over 14 days.	Alginates	29-37	vascular endothelial growth factor A	Homo sapiens	11-15
33733622-4	2021	Release of VEGF from sulfate-alginate and heparin-alginate bulk hydrogels and microspheres was sustained over 14 days.	Alginates	50-58	vascular endothelial growth factor A	Homo sapiens	11-15
33733622-5	2021	In vitro evaluation with human induced pluripotent stem cell (hiPSC)-derived endothelial cells and aortic ring assay in a chemically defined hydrogel demonstrates development of primitive three-dimensional vessel-like networks in the presence of VEGF released from the chemically modified alginate microspheres.	Alginates	289-297	vascular endothelial growth factor A	Homo sapiens	246-250
33733622-6	2021	Furthermore, our results suggest that the sulfate groups available on the chemically modified alginate microspheres promote some new vessel formation even in VEGF-free samples.	Alginates	94-102	vascular endothelial growth factor A	Homo sapiens	158-162
33221003-10	2021	The TBBPA debromination rate by S-nZVI@alginate is initially enhanced followed by a decrease with an increase in TBBPA concentration, while it can increase 3.3-, 8.9- and 5.6-fold by increasing S-nZVI@alginate dosage, decreasing pH and adding co-contaminant Cd2+, respectively.	Alginates	39-47	CD2 molecule	Homo sapiens	258-261
33221003-10	2021	The TBBPA debromination rate by S-nZVI@alginate is initially enhanced followed by a decrease with an increase in TBBPA concentration, while it can increase 3.3-, 8.9- and 5.6-fold by increasing S-nZVI@alginate dosage, decreasing pH and adding co-contaminant Cd2+, respectively.	Alginates	201-209	CD2 molecule	Homo sapiens	258-261
33748600-0	2021	Modified Alginate-Based Hydrogel as a Carrier of the CB2 Agonist JWH133 for Bone Engineering.	Alginates	9-17	cannabinoid receptor 2	Rattus norvegicus	53-56
33559717-4	2021	Our results show that calcium-crosslinked alginate-encapsulated bacteria effectively removed Cd2+ ions from cadmium-polluted water.	Alginates	42-50	CD2 molecule	Homo sapiens	93-96
33559717-10	2021	Our results indicated that calcium-crosslinked alginate-encapsulated bacteria are suitable for depletion of Cd2+ in polluted water and for production of CdS nanoparticles.	Alginates	47-55	CD2 molecule	Homo sapiens	108-111
33559717-11	2021	These calcium-crosslinked alginate-encapsulated bacteria are safe for biological manipulation and can be widely used to produce CdS nanoparticles during bioremediation of Cd2+-polluted water.	Alginates	26-34	CD2 molecule	Homo sapiens	171-174
33559717-12	2021	KEY POINTS:   Calcium-crosslinked alginate-encapsulated bacteria can effectively precipitate Cd2+ in water coupled with production of CdS quantum dots.	Alginates	34-42	CD2 molecule	Homo sapiens	93-96
33476613-0	2021	An alginate-poly(acrylamide) hydrogel with TGF-beta3 loaded nanoparticles for cartilage repair: Biodegradability, biocompatibility and protein adsorption.	Alginates	3-11	transforming growth factor, beta 3	Rattus norvegicus	43-52
33516375-0	2021	Visual detection of alkaline phosphatase based on ascorbic acid-triggered gel-sol transition of alginate hydrogel.	Alginates	96-104	alkaline phosphatase, placental	Homo sapiens	20-40
33436245-2	2021	The TN hydrogel composed of Poly (N-isopropylacrylamide) (PNIPAAm)/sodium alginate (SA)/ Poly (vinyl alcohol) (PVA) exhibited excellent swelling ratio, swelling-deswelling behavior and antibacterial property.	Alginates	67-82	C-type lectin domain family 3 member B	Homo sapiens	4-6
33436245-2	2021	The TN hydrogel composed of Poly (N-isopropylacrylamide) (PNIPAAm)/sodium alginate (SA)/ Poly (vinyl alcohol) (PVA) exhibited excellent swelling ratio, swelling-deswelling behavior and antibacterial property.	Alginates	84-86	C-type lectin domain family 3 member B	Homo sapiens	4-6
33436245-3	2021	Results indicated that introduction of SA could improve water retention capabilities of TN hydrogels.	Alginates	39-41	C-type lectin domain family 3 member B	Homo sapiens	88-90
33516375-2	2021	In this work, we fabricated an ascorbic acid (AA)-responsive alginate hydrogel for the visual detection of alkaline phosphatase (ALP).	Alginates	61-69	alkaline phosphatase, placental	Homo sapiens	107-127
33516375-2	2021	In this work, we fabricated an ascorbic acid (AA)-responsive alginate hydrogel for the visual detection of alkaline phosphatase (ALP).	Alginates	61-69	alkaline phosphatase, placental	Homo sapiens	129-132
33068063-0	2021	Thymoquinone loaded calcium alginate and polyvinyl alcohol carrier inhibits the 7,12-dimethylbenz[a]anthracene-induced hamster oral cancer via the down-regulation of PI3K/AKT/mTOR signaling pathways.	Alginates	20-36	serine/threonine-protein kinase mTOR	Mesocricetus auratus	175-179
33444652-1	2021	A series of multifunctional conductive hydrogels (denoted as SA-B-DAPPy) is developed by combining sodium alginate (SA) and dopamine functionalized polypyrrole (DAPPy) nanofibers with borax as a cross-linking agent.	Alginates	99-114	SH3 domain binding protein 5	Homo sapiens	61-65
33715405-0	2021	Synthesis and evaluation of an alginate-methacrylate xerogel for insulin delivery towards wound healing applications.	Alginates	31-39	insulin	Homo sapiens	65-72
33715405-3	2021	The aim of this study was to develop stable alginate based scaffold for insulin delivery toward wound care.	Alginates	44-52	insulin	Homo sapiens	72-79
33715405-7	2021	Conclusion: Grafting improved the strength and stability of alginate xerogel and the results suggest the application of insulin loaded AGM2S xerogels as a potential wound healing material.	Alginates	60-68	insulin	Homo sapiens	120-127
33428954-0	2021	Development and statistical optimization of alginate-Neusilin US2 micro-composite beads to elicit gastric stability and sustained action of hesperidin.	Alginates	44-52	usherin	Homo sapiens	62-65
33428954-1	2021	The Alginate-Neusilin US2 micro-composite (MC) beads were fabricated and optimized for oral delivery of hesperidin (HES).	Alginates	4-12	usherin	Homo sapiens	22-25
33718672-4	2021	Significantly, several potential marker genes, such as PFKFB3, KDM6B, had been identified via comparatively analyzing their expression in P0 and P1 chondrocytes as well as in 3D constructs (i.e. chondrocyte-laden alginate hydrogel and HA-MA hydrogel) at both mRNA and protein level.	Alginates	213-221	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	55-61
33430704-0	2021	Assessing the angiogenic efficacy of pleiotrophin released from injectable heparin-alginate gels.	Alginates	83-91	pleiotrophin	Homo sapiens	37-49
33673329-5	2021	Biopolymeric microcapsule formulations (chitosan/alginate microcapsule loaded with PGR) suitable for application in agriculture were prepared and characterized.	Alginates	49-57	progesterone receptor	Homo sapiens	83-86
33357879-2	2021	Herein, inspired by nanocomposite, double-network (DN) and mussel chemistry, a new Graphene oxide@Dopamine/Alginate/Poly(acrylic acid-co-acrylamide) [GO@DA/Alginate/P(AAc-co-AAm)] hydrogel was fabricated through one-pot in-situ radical copolymerization.	Alginates	107-115	glycine-N-acyltransferase	Homo sapiens	167-170
33357879-2	2021	Herein, inspired by nanocomposite, double-network (DN) and mussel chemistry, a new Graphene oxide@Dopamine/Alginate/Poly(acrylic acid-co-acrylamide) [GO@DA/Alginate/P(AAc-co-AAm)] hydrogel was fabricated through one-pot in-situ radical copolymerization.	Alginates	156-164	glycine-N-acyltransferase	Homo sapiens	167-170
33357879-4	2021	Alginate/P(AAc-co-AAm) DN matrix, physically and chemically crosslinked by Fe3+ and N,N"-Methylenebisacrylamide, made hydrogels ultrastretchable, self-healing and biocompatible.	Alginates	0-8	glycine-N-acyltransferase	Homo sapiens	11-14
33357879-0	2021	Ultrastretchable, self-adhesive, strain-sensitive and self-healing GO@DA/Alginate/P(AAc-co-AAm) multifunctional hydrogels via mussel-inspired chemistry.	Alginates	73-81	glycine-N-acyltransferase	Homo sapiens	84-87
33540681-4	2021	In the current work, we determined whether the effect of CLytA-DAAO immobilized in magnetic nanoparticles, gold nanoparticles, and alginate capsules offered some advantages as compared to the free CLytA-DAAO.	Alginates	131-139	D-amino acid oxidase	Homo sapiens	63-67
33332959-5	2021	An integrin-binding peptide (RGD) and a vascular endothelial growth factor-mimetic peptide with a protease-sensitive linker are conjugated onto a biodegradable alginate to synergistically promote vascular morphogenesis and capillary-scale endothelial tube formation.	Alginates	160-168	vascular endothelial growth factor A	Homo sapiens	40-74
33592853-4	2021	Recombinant human growth hormone and alginate dressing have been used in clinical, but there is lack of the relevant evidence of its effectiveness and safety, so this study evaluates the clinical effectiveness and safety of recombinant human growth hormone combined with alginate dressing in the treatment of DFU by systematic evaluation, the purpose is to provide a theoretical basis for the treatment of diabetic foot ulcer.	Alginates	37-45	growth hormone 1	Homo sapiens	242-256
33385687-6	2021	In these studies, we observed significant increases in calcium deposition by MSC spheroids loaded with BMP-2-HA in viscoelastic gels compared to soluble BMP-2, which was greater than spheroids entrapped in all elastic alginate gels.	Alginates	218-226	bone morphogenetic protein 2	Homo sapiens	103-108
33159581-7	2021	Furthermore, SA/Col loaded with hUC-MSCs significantly lowered the expression of NLRP3 inflammasome-related proteins (p < 0.05).	Alginates	13-15	NLR family pyrin domain containing 3	Homo sapiens	81-86
33159581-8	2021	Taken together, our results suggest that SA/Col loaded with hUC-MSCs promotes skin wound healing via partly inhibiting NLRP3 pathway, which has potential to the treatment of skin wounds.	Alginates	41-43	NLR family pyrin domain containing 3	Homo sapiens	119-124
32562342-9	2021	CONCLUSION: We have gathered preliminary evidence that the two adult stem cell types within alginate microcapsules, may synergistically promote tracer insulin production, while "freezing" the autoimmune disease process, and help reversal of the recent onset hyperglycemia in a spontaneous, autoimmune rodent model of diabetes, the NOD mouse, with no need for pharmacologic immunosuppression.	Alginates	92-100	insulin	Homo sapiens	151-158
32162778-3	2021	Here we showed that sigma 22 factor (AlgT/U), an activator of alginate biosynthesis, repressed twitching motility by inhibiting the expression of pilin (PilA) through the intermediate transcriptional regulator AmrZ, which directly bound to the promoter region of pilA in both mucoid strain FRD1 and non-mucoid strain PAO1.	Alginates	62-70	alginate and motility regulator Z	Pseudomonas aeruginosa PAO1	210-214
33573020-0	2021	Dynamic Mechanical Control of Alginate-Fibronectin Hydrogels with Dual Crosslinking: Covalent and Ionic.	Alginates	30-38	fibronectin 1	Homo sapiens	39-50
33181214-12	2021	On the other hand, Alginate-TiO2 TMZ nanoparticles reduced the levels of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-kappaB).	Alginates	19-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	119-140
33181214-12	2021	On the other hand, Alginate-TiO2 TMZ nanoparticles reduced the levels of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-kappaB).	Alginates	19-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-151
33506023-0	2021	Alginate Oligosaccharide Ameliorates D-Galactose-Induced Kidney Aging in Mice through Activation of the Nrf2 Signaling Pathway.	Alginates	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	104-108
33099059-0	2021	Toll-like receptor 2-modulating pectin-polymers in alginate-based microcapsules attenuate immune responses and support islet-xenograft survival.	Alginates	51-59	toll-like receptor 2	Mus musculus	0-20
33099059-5	2021	DM18-pectin/alginate microcapsules show a significant decrease of DAMP-induced Toll-Like Receptor-2 mediated immune activation in vitro, and reduce peri-capsular fibrosis in vivo in mice compared to higher DM-pectin/alginate microcapsules and conventional alginate microcapsules.	Alginates	12-20	toll-like receptor 2	Mus musculus	79-99
33136364-4	2021	Here, we report a collagen-alginate hydrogel with a filamentous architecture and a 20-fold variation in stiffness, achieved independently of other properties, used for the evaluation of estrogen receptor-positive breast cancer spheroid response to doxorubicin.	Alginates	27-35	estrogen receptor 1	Homo sapiens	186-203
33617502-0	2021	Effective removal of Cu(II), Pb(II) and Cd(II) by sodium alginate intercalated MgAl-layered double hydroxide: adsorption properties and mechanistic studies.	Alginates	50-65	submaxillary gland androgen regulated protein 3B	Homo sapiens	29-35
33617502-2	2021	SA-LDH was characterized by XRD, FTIR, XPS and employed as adsorbent for Cd(II), Pb(II), Cu(II) elimination.	Alginates	0-2	submaxillary gland androgen regulated protein 3B	Homo sapiens	81-87
33617502-5	2021	The maximum adsorption capacities of SA-LDH for Cu(II), Pb(II) and Cd(II) reached 0.945, 1.176 and 0.850 mmol/g, respectively.	Alginates	37-39	submaxillary gland androgen regulated protein 3B	Homo sapiens	56-62
33617502-7	2021	The results showed that Cd(II), Pb(II) and Cu(II) may be removed by SA-LDH via (i) bonding or complexation with Sur-OH or Sur-O- of SA-LDH, (ii) precipitation of metal hydroxides or carbonates, (iii) isomorphic substitution, and (iv) chelation with -COO- in the interlayers.	Alginates	68-70	submaxillary gland androgen regulated protein 3B	Homo sapiens	32-38
33617502-7	2021	The results showed that Cd(II), Pb(II) and Cu(II) may be removed by SA-LDH via (i) bonding or complexation with Sur-OH or Sur-O- of SA-LDH, (ii) precipitation of metal hydroxides or carbonates, (iii) isomorphic substitution, and (iv) chelation with -COO- in the interlayers.	Alginates	132-134	submaxillary gland androgen regulated protein 3B	Homo sapiens	32-38
33472983-2	2021	OligoG CF-5/20, a low-molecular-weight inhaled alginate oligomer therapy, is currently in phase IIb/III clinical trials in CF patients.	Alginates	47-55	CXXC finger protein 5	Homo sapiens	7-14
33147471-13	2021	MSCs cultured on alginate-based scaffold in the differentiation medium containing beta-carotene expressed higher levels of rhodopsin protein compared to a 2D culture.	Alginates	17-25	rhodopsin	Mus musculus	123-132
33259898-12	2021	The increased release was in bursts followed by similar sustained release rates suggesting that the human lysozyme temporarily disrupted the DNA crosslinks which were then re-established or were influenced by interactions between DNA and alginate.	Alginates	238-246	lysozyme	Homo sapiens	106-114
33147471-14	2021	Also, the expressions of Nestin, Rhodopsin, and RPE65 genes were upregulated in beta-carotene-treated MSCs grown on alginate-based scaffolds.	Alginates	116-124	nestin	Mus musculus	25-31
33147471-14	2021	Also, the expressions of Nestin, Rhodopsin, and RPE65 genes were upregulated in beta-carotene-treated MSCs grown on alginate-based scaffolds.	Alginates	116-124	rhodopsin	Mus musculus	33-42
33147471-14	2021	Also, the expressions of Nestin, Rhodopsin, and RPE65 genes were upregulated in beta-carotene-treated MSCs grown on alginate-based scaffolds.	Alginates	116-124	retinal pigment epithelium 65	Mus musculus	48-53
33159942-7	2021	Moreover, it could degrade sodium alginate, polyM and polyG into oligosaccharides with degrees of polymerization (Dps) 2-5, which exhibit perfect product specificity.	Alginates	27-42	decaprenyl diphosphate synthase subunit 1	Homo sapiens	114-117
33545882-11	2021	The dispersion of the CNT-PLGA microspheres, covered by NSCs, into alginate gel in the presence of induction factors was found to notably enhance the expression of Sox2-SYP and beta-Tubulin III neuronal markers.	Alginates	67-75	SRY-box transcription factor 2	Homo sapiens	164-168
33259781-3	2021	The aim of present study was to evaluate the immunogenicity of alginate (Alg) antigen in conjugation with SLN as a candidate for nanovaccine against P. aeruginosa in mouse model.	Alginates	63-71	sarcolipin	Mus musculus	106-109
33259781-3	2021	The aim of present study was to evaluate the immunogenicity of alginate (Alg) antigen in conjugation with SLN as a candidate for nanovaccine against P. aeruginosa in mouse model.	Alginates	73-76	sarcolipin	Mus musculus	106-109
33259781-5	2021	To increase the immunogenicity of alginate, SLN was used that is useful in drug delivery and can boost prolonged effectiveness.	Alginates	34-42	sarcolipin	Mus musculus	44-47
33545882-11	2021	The dispersion of the CNT-PLGA microspheres, covered by NSCs, into alginate gel in the presence of induction factors was found to notably enhance the expression of Sox2-SYP and beta-Tubulin III neuronal markers.	Alginates	67-75	synaptophysin	Homo sapiens	169-172
32679415-1	2020	The aim of the present paper was to unravel the effect of a standardized in vitro European protocol of digestion-fermentation over Ca(II)-alginate beads synthesized with sugars and biopolymers.	Alginates	138-146	carbonic anhydrase 2	Homo sapiens	131-137
33912496-0	2020	Utilizing Calcium Alginate for the Assessment of Bone Morphogenetic Protein 15 Induction Effect on the Differentiation of Mesenchymal Stem Cell Derived from Human Follicular Fluid to Oocyte-Like Structure.	Alginates	10-26	bone morphogenetic protein 1	Homo sapiens	49-75
33348331-4	2021	We observe that coaxial alginate fibers promote T-cell expansion, less exhausted and enable CD4+ T-cell differentiation into central memory-like phenotype (Tcm), CD8+ T-cells differentiation into effector memory subsets (Tem), while alginate-gelatin scaffolds bring T-cells into a relatively resting state.	Alginates	24-32	CD4 molecule	Homo sapiens	92-95
33348331-4	2021	We observe that coaxial alginate fibers promote T-cell expansion, less exhausted and enable CD4+ T-cell differentiation into central memory-like phenotype (Tcm), CD8+ T-cells differentiation into effector memory subsets (Tem), while alginate-gelatin scaffolds bring T-cells into a relatively resting state.	Alginates	24-32	CD8a molecule	Homo sapiens	162-165
32679415-5	2020	The microstructural analysis of Ca(II)-alginate showed an advantageous behavior: they slightly changed in oral and gastric fluids and partially dissolved their structure in intestinal fluid, where absorption occurs.	Alginates	39-47	carbonic anhydrase 2	Homo sapiens	32-38
33403253-1	2020	Two controlled-released fertilizers of phosphorylated alginate grafted with polyacrylamide (P-Alg-g-PAM) were synthesized.	Alginates	54-62	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	100-103
32679321-0	2020	Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application.	Alginates	0-8	elastin	Homo sapiens	15-22
33002535-3	2020	ATR-FTIR confirmed the existence of intermolecular hydrogen bonding between SA/mPEG in bio-polymeric membranes.	Alginates	76-78	ATR serine/threonine kinase	Homo sapiens	0-3
33010273-1	2020	A prospective novel technique has been developed for evaluation the capacity of alginate as a natural polymer absorbent for binding Ca (II), Sr (II) and Ba(II) as alkaline earth metal ions for formation of coordination biopolymer hydrogel complexes.	Alginates	80-88	carbonic anhydrase 2	Homo sapiens	132-139
32986180-0	2020	Alginate oligosaccharide protects endothelial cells against oxidative stress injury via integrin-alpha/FAK/PI3K signaling.	Alginates	0-8	protein tyrosine kinase 2	Homo sapiens	103-106
32950517-3	2020	In this study, the influence of humic acid (HA)/sodium alginate (SA) fractions in the structure and resistance of cake layer on the membrane surface was investigated.	Alginates	48-63	acyl-CoA synthetase medium chain family member 3	Homo sapiens	65-67
33397079-3	2021	Natural alginate and gelatin-methacryloyl entangled hydrogel that is synthesized via fast exchange of ions and ultraviolet irradiation provide proper mechanical strength and excellent biocompatibility and can also serve as a reservoir for netrin-1.	Alginates	8-16	netrin 1	Homo sapiens	239-247
32933688-0	2020	Preparation and characterization of tissue-factor-loaded alginate: Toward a bioactive hemostatic material.	Alginates	57-65	coagulation factor III, tissue factor	Homo sapiens	36-49
32698067-1	2020	Sodium alginates with different mannuronate to guluronate units ratio ALG1 and ALG2 were employed in the formation of insoluble complexes with anthocyanins (ATC) extracted from Vaccinium myrtilus by exploiting the electrostatic interaction between carboxylate groups of sodium alginate (ALG) and flavylium cations of ATC.	Alginates	0-16	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Homo sapiens	70-74
32679321-1	2020	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human elastin-like polypeptide (HELP)) with alginate (ALG) to obtain a composite with enhanced properties.	Alginates	219-227	elastin	Homo sapiens	135-142
33179297-3	2021	The goal of this study was to investigate whether the local delivery of anti-VEGF antibody (alpha-VEGF; 7.5mug) from alginate:chitosan hydrogels to the tibial physeal injury site in rats prevents bony bar formation.	Alginates	117-125	vascular endothelial growth factor A	Rattus norvegicus	77-81
32698067-1	2020	Sodium alginates with different mannuronate to guluronate units ratio ALG1 and ALG2 were employed in the formation of insoluble complexes with anthocyanins (ATC) extracted from Vaccinium myrtilus by exploiting the electrostatic interaction between carboxylate groups of sodium alginate (ALG) and flavylium cations of ATC.	Alginates	0-16	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	79-83
32698067-1	2020	Sodium alginates with different mannuronate to guluronate units ratio ALG1 and ALG2 were employed in the formation of insoluble complexes with anthocyanins (ATC) extracted from Vaccinium myrtilus by exploiting the electrostatic interaction between carboxylate groups of sodium alginate (ALG) and flavylium cations of ATC.	Alginates	270-285	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	79-83
32698067-6	2020	Thermogravimetric analysis showed that the rate of ALG and ATC complex decomposition also depended on the type of ALG used and was 2.5 times higher for ALG2 and ATC complex compared to ALG1 and ATC complex.	Alginates	51-54	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	152-156
32698067-6	2020	Thermogravimetric analysis showed that the rate of ALG and ATC complex decomposition also depended on the type of ALG used and was 2.5 times higher for ALG2 and ATC complex compared to ALG1 and ATC complex.	Alginates	51-54	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Homo sapiens	185-189
32803696-0	2020	SIRT1+ Adipose Derived Mesenchymal Stromal Stem Cells (ASCs) Suspended in Alginate Hydrogel for the Treatment of Subchondral Bone Cyst in Medial Femoral Condyle in the Horse.	Alginates	74-82	sirtuin 1	Equus caballus	0-5
32424937-0	2020	Coinhibition of S1PR1 and GP130 by siRNA-loaded alginate-conjugated trimethyl chitosan nanoparticles robustly blocks development of cancer cells.	Alginates	48-56	sphingosine-1-phosphate receptor 1	Mus musculus	16-21
32424937-0	2020	Coinhibition of S1PR1 and GP130 by siRNA-loaded alginate-conjugated trimethyl chitosan nanoparticles robustly blocks development of cancer cells.	Alginates	48-56	interleukin 6 signal transducer	Mus musculus	26-31
32424937-4	2020	Therefore, we silenced STAT3 upstream molecules including the S1PR1 and GP130 molecules in cancer cells using small interfering RNA (siRNA)-loaded alginate-conjugated trimethyl chitosan (ATMC) nanoparticles (NPs).	Alginates	147-155	signal transducer and activator of transcription 3	Mus musculus	23-28
32991717-0	2020	The Alginate Immobilization of Metabolic Enzymes (AIME) Platform Retrofits an Estrogen Receptor Transactivation Assay with Metabolic Competence.	Alginates	4-12	estrogen receptor 1	Homo sapiens	78-95
33261225-1	2020	Characterization and Mathematical Modeling of Alginate/Chitosan-Based Nanoparticles Releasing the Chemokine CXCL12 to Attract Glioblastoma Cells.	Alginates	46-54	C-X-C motif chemokine ligand 12	Homo sapiens	108-114
32891611-0	2020	SA/G hydrogel containing hCAP-18/LL-37-engineered WJ-MSCs-derived conditioned medium promoted wound healing in rat model of excision injury.	Alginates	0-2	cathelicidin antimicrobial peptide	Homo sapiens	25-32
33141369-2	2020	In this work, gelatin methacrylate (GelMA)/alginate hydrogel scaffolds were obtained by 3D printing and 14-3-3epsilon protein was encapsulated in the hydrogel to induce osteogenic differentiation of human adipose-derived mesenchymal stem cells (hASC).	Alginates	43-51	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	104-117
32711026-5	2020	In this current study, we developed and tested an injectable, slow-release, uniform, and optimally loaded alginate nanoformulation of CCL21 as a means to provide prolonged intratumoral treatment.	Alginates	106-114	C-C motif chemokine ligand 21	Homo sapiens	134-139
32721736-4	2020	The removal efficiency of Pb2+/Cd2+ by SA/S2- gel were both increased compared with pure SA gel.	Alginates	39-41	CD2 molecule	Homo sapiens	31-34
32721736-4	2020	The removal efficiency of Pb2+/Cd2+ by SA/S2- gel were both increased compared with pure SA gel.	Alginates	89-91	CD2 molecule	Homo sapiens	31-34
33190050-0	2020	Alkaline phosphatase-responsive Zn2+ double-triggered nucleotide capped gold nanoclusters/ alginate hydrogel with recyclable nanozyme capability.	Alginates	91-99	alkaline phosphatase, placental	Homo sapiens	0-20
32711026-6	2020	The alginate-nanoformulated CCL21, when injected intratumorally into mice bearing neuroblastoma lesions, significantly prolonged survival and decreased the tumor growth rate compared to CCL21 alone, empty nanoparticles, or buffer.	Alginates	4-12	C-C motif chemokine ligand 21	Homo sapiens	28-33
32711026-6	2020	The alginate-nanoformulated CCL21, when injected intratumorally into mice bearing neuroblastoma lesions, significantly prolonged survival and decreased the tumor growth rate compared to CCL21 alone, empty nanoparticles, or buffer.	Alginates	4-12	C-C motif chemokine ligand 21	Homo sapiens	186-191
33141369-7	2020	The results are relevant for future developments of GelMA/alginate for bone tissue engineering given the positive effect of 14-3-3epsilon protein on both cell adhesion and proliferation.	Alginates	58-66	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	124-137
33154637-0	2020	Response Surface Methodology for Statistical Optimization of Chitosan/Alginate Nanoparticles as a Vehicle for Recombinant Human Bone Morphogenetic Protein-2 Delivery.	Alginates	70-78	bone morphogenetic protein 2	Homo sapiens	128-156
33089564-3	2020	Here, a facile and general strategy toward color-tunable p-RTP from blue to orange-red based on amidation grafting of luminophores onto sodium alginate (SA) chains, resulting in amorphous polymers with distinct p-RTP and even impressively excitation-dependent and time-dependent afterglows is reported.	Alginates	136-151	MORN repeat containing 4	Homo sapiens	59-62
33089564-3	2020	Here, a facile and general strategy toward color-tunable p-RTP from blue to orange-red based on amidation grafting of luminophores onto sodium alginate (SA) chains, resulting in amorphous polymers with distinct p-RTP and even impressively excitation-dependent and time-dependent afterglows is reported.	Alginates	136-151	MORN repeat containing 4	Homo sapiens	213-216
33089564-3	2020	Here, a facile and general strategy toward color-tunable p-RTP from blue to orange-red based on amidation grafting of luminophores onto sodium alginate (SA) chains, resulting in amorphous polymers with distinct p-RTP and even impressively excitation-dependent and time-dependent afterglows is reported.	Alginates	153-155	MORN repeat containing 4	Homo sapiens	59-62
33089564-3	2020	Here, a facile and general strategy toward color-tunable p-RTP from blue to orange-red based on amidation grafting of luminophores onto sodium alginate (SA) chains, resulting in amorphous polymers with distinct p-RTP and even impressively excitation-dependent and time-dependent afterglows is reported.	Alginates	153-155	MORN repeat containing 4	Homo sapiens	213-216
33089564-4	2020	p-RTP is associated with the unique semi-rigidified SA chains, effective hydrogen bonding network, and oxygen barrier properties of SA, whereas excitation-dependent and time-dependent afterglows should stem from the formation of diversified p-RTP emissive species with comparable but different lifetimes.	Alginates	52-54	MORN repeat containing 4	Homo sapiens	2-5
33089564-4	2020	p-RTP is associated with the unique semi-rigidified SA chains, effective hydrogen bonding network, and oxygen barrier properties of SA, whereas excitation-dependent and time-dependent afterglows should stem from the formation of diversified p-RTP emissive species with comparable but different lifetimes.	Alginates	132-134	MORN repeat containing 4	Homo sapiens	2-5
33313243-6	2020	CD63-VEGFC/exos were embedded in sodium alginate hydrogel and their effect on lymphedema was evaluated by a mouse model.	Alginates	33-48	vascular endothelial growth factor C	Mus musculus	5-10
33313243-9	2020	Using CD63-VEGFC/egos in sodium alginate hydrogel enabled a sequenced release of exosomes and markedly improved lymphedema in a mouse model.	Alginates	25-40	vascular endothelial growth factor C	Mus musculus	11-16
32911274-7	2020	A lower removal rate was observed in the organic waste, although calcium alginate beads have also been able to achieve high sorption capacity in less than 4 h. With the organic waste, the highest value of sorption capacity of 241Am was 4.38 x 10-7 mmol g-1 with an initial 241Am concentration of 2.31 x 10-8 mmol L-1.	Alginates	65-81	L1 cell adhesion molecule	Mus musculus	313-316
32150760-6	2020	Finally, regulatory T-cell enrichment in the dermis and periodontal tissue in response to alginate hydrogels delivering TSLP and GM-CSF was examined in vivo in mice using immunohistochemistry and live-animal imaging.	Alginates	90-98	thymic stromal lymphopoietin	Mus musculus	120-124
32150760-6	2020	Finally, regulatory T-cell enrichment in the dermis and periodontal tissue in response to alginate hydrogels delivering TSLP and GM-CSF was examined in vivo in mice using immunohistochemistry and live-animal imaging.	Alginates	90-98	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	129-135
32150760-9	2020	An intradermal injection of an alginate hydrogel releasing GM-CSF enhanced DC numbers and the addition of TSLP enriched FOXP3+ regulatory T-cells locally.	Alginates	31-39	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	59-65
32867602-3	2020	The objective of this study was to determine the possible mechanism about how the microencapsulated hUCMSCs made by alginate-poly-lysine-alginate (A-P-A) transfected with HGF could ameliorate liver fibrosis through TGF-beta1/Smad signaling pathway.	Alginates	116-124	hepatocyte growth factor	Homo sapiens	171-174
32867602-3	2020	The objective of this study was to determine the possible mechanism about how the microencapsulated hUCMSCs made by alginate-poly-lysine-alginate (A-P-A) transfected with HGF could ameliorate liver fibrosis through TGF-beta1/Smad signaling pathway.	Alginates	116-124	transforming growth factor beta 1	Homo sapiens	215-224
32964253-3	2020	Through optimization of the SERS conditions, including the volume of SA-protected AgNPs solution, pH of Britton-Robinson (BR) buffer solution and concentration of NaCl solution, linear responses were obtained for PTU and MTZ in the concentration ranges of 3.02 x 10-9-1.06 x 10-5 mol L-1 and 1.21 x 10-9-1.21 x 10-5 mol L-1, respectively.	Alginates	69-71	L1 cell adhesion molecule	Homo sapiens	284-293
32645596-8	2020	Second-order reaction rates of humic acid sodium salt, sodium alginate, Suwannee River humic acid and bovine serum albumin were calculated as 1.30 x 108 M-1 s-1, 1.39 x 108 M-1 s-1, 1.03 x 108 M-1 s-1, and 3.17 x 107 M-1 s-1, respectively.	Alginates	55-70	albumin	Homo sapiens	109-122
33154637-1	2020	Purpose: In this study, chitosan/alginate nanoparticles are prospected as a carrier for controlled release of recombinant human bone morphogenetic protein-2 (rhBMP-2).	Alginates	33-41	bone morphogenetic protein 2	Homo sapiens	128-156
33068297-10	2021	Human VF fibroblasts encapsulated in alginate microspheres induced the production of interleukin (IL)-8 and IL-4 at 24 hours.	Alginates	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	85-103
33097090-13	2020	RESULTS: HNF4alpha-UMSCs can enhance the function of primary hepatocytes in alginate-poly-L-lysine-alginate (APA) microcapsules.	Alginates	76-84	hepatic nuclear factor 4, alpha	Mus musculus	9-18
33068297-10	2021	Human VF fibroblasts encapsulated in alginate microspheres induced the production of interleukin (IL)-8 and IL-4 at 24 hours.	Alginates	37-45	interleukin 4	Homo sapiens	108-112
33036643-0	2020	Inhibition of hypertrophy and improving chondrocyte differentiation by MMP-13 inhibitor small molecule encapsulated in alginate-chondroitin sulfate-platelet lysate hydrogel.	Alginates	119-127	matrix metallopeptidase 13	Homo sapiens	71-77
32512084-12	2020	We also found enhanced anti-oxidant capacity and SOD and GPx activity in cells after being-encapsulated inside Alginate-Gelatin microspheres (p < 0.05) coincided with increased Nrf-2 synthesis (p < 0.05) compared to control cells.	Alginates	111-119	NFE2 like bZIP transcription factor 2	Rattus norvegicus	177-182
32512084-13	2020	The expression of Connexin-43, alpha-actinin, and myosin light chain was significantly up-regulated, showing cyto-functional effect of Alginate-Gelatin microspheres after 7-days.	Alginates	135-143	gap junction protein, alpha 1	Rattus norvegicus	18-29
32554142-4	2020	Polyacrylamide/sodium alginate (PAM/Alginate) double-network (DN) tough hydrogel could address these issues as the potential couplant for intraoral ultrasound imaging.	Alginates	15-30	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	32-35
32554142-7	2020	Moreover, the PAM/Alginate DN hydrogel shows lower cytotoxicity to both cancer (Hela) and fibroblast cells (MRC-5).	Alginates	18-26	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	14-17
32579250-7	2020	Immobilisation maintained metal tolerance, while AtHMA4-expressing cells in alginate showed a concentration-dependent increase in metal biosorption that was significantly greater than alginate beads composed of wild type cells.	Alginates	76-84	heavy metal atpase 4	Arabidopsis thaliana	49-55
32763614-4	2020	The immunomodulatory extracellular matrix hydrogels (iECM) consist of an interpenetrating network of click functionalized-alginate and fibrillar collagen, in which interferon gamma (IFN-gamma) loaded heparin-coated beads are incorporated.	Alginates	122-130	interferon gamma	Homo sapiens	164-191
32599358-5	2020	Using ovalbumin (OVA) as a model antigen, we determined that alginate microencapsulation abrogates direct CD8+ T cell activation by interrupting donor-host interaction; however, indirect T cell activation, mediated by host antigen presenting cells (APCs) primed with shed donor antigens, still occurs.	Alginates	61-69	CD8a molecule	Homo sapiens	106-109
33000765-3	2020	Herein, we engineer an innovative alginate-fibronectin microfluidic-based carrier construct (termed a chondrobag) equipped with solid phase presentation of growth factors that support skeletal stem cell chondrogenic differentiation while preserving human articular chondrocyte phenotype.	Alginates	34-42	fibronectin 1	Homo sapiens	43-54
32579250-7	2020	Immobilisation maintained metal tolerance, while AtHMA4-expressing cells in alginate showed a concentration-dependent increase in metal biosorption that was significantly greater than alginate beads composed of wild type cells.	Alginates	184-192	heavy metal atpase 4	Arabidopsis thaliana	49-55
32450354-1	2020	In the present work, talc (a low-cost clay) encapsulated salts alginate (TAL) beads were synthesized by cross-linking with lanthanum ion and tested for phosphate adsorption.	Alginates	63-71	transaldolase 1	Homo sapiens	73-76
32718598-3	2020	The chelation ability of the films improved with increasing number of (CS/ALG)n multilayers, and Cu2+ chelating quantity of PP-g-PAA/(CS/ALG)15.5 films was about 3.4 umol/cm2 for 72 h at pH about 5, improved by about 9.92 % as compared with PP-g-PAA films.	Alginates	74-77	serglycin	Homo sapiens	124-128
32718598-3	2020	The chelation ability of the films improved with increasing number of (CS/ALG)n multilayers, and Cu2+ chelating quantity of PP-g-PAA/(CS/ALG)15.5 films was about 3.4 umol/cm2 for 72 h at pH about 5, improved by about 9.92 % as compared with PP-g-PAA films.	Alginates	137-140	serglycin	Homo sapiens	124-128
32600722-4	2020	The synthesized SA/bFGF@pNIPAM/DS@p(NIPAM-co-AA) hydrogel presented a desirable storage modulus of ~4500 Pa, a high water equilibrium swelling ratio of ~90, an appropriate water vapor transmission rate of ~2300 g/m2/day, and nontoxicity to human skin fibroblasts.	Alginates	16-18	fibroblast growth factor 2	Homo sapiens	19-23
32600680-2	2020	In the present study, two different PLGA-Alginate scaffolds, a hydrogel (HY) and a solid sponge (SS), were developed for beta-estradiol and BMP-2 sustained delivery for bone regeneration in osteoporosis.	Alginates	41-49	bone morphogenetic protein 2	Rattus norvegicus	140-145
32600722-7	2020	These findings indicate SA/bFGF@pNIPAM/DS@p(NIPAM-co-AA) composite hydrogel is a potential dressing for wound repair.	Alginates	24-26	fibroblast growth factor 2	Rattus norvegicus	27-31
32600680-3	2020	beta-Estradiol and BMP-2 were encapsulated in PLGA and PLGA-Alginate microspheres respectively.	Alginates	60-68	bone morphogenetic protein 2	Rattus norvegicus	19-24
32946427-0	2020	Angiogenic factors secreted from human ASC spheroids entrapped in an alginate-based hierarchical structure via combined 3D printing/electrospinning system.	Alginates	69-77	PYD and CARD domain containing	Homo sapiens	39-42
32600722-3	2020	Sodium alginate (SA) crosslinked by calcium ion acted as the continuous phase, and thermosensitive bFGF-loaded poly(N-isopropylacrylamide) nanogels (pNIPAM NGs, LCST1 ~33  C) and DS-loaded p(N-isopropylacrylamide-co-acrylic acid) nanogels [p(NIPAM-co-AA) NGs, LCST2 ~40  C] acted as the dispersed phase.	Alginates	0-15	fibroblast growth factor 2	Homo sapiens	99-103
32600722-3	2020	Sodium alginate (SA) crosslinked by calcium ion acted as the continuous phase, and thermosensitive bFGF-loaded poly(N-isopropylacrylamide) nanogels (pNIPAM NGs, LCST1 ~33  C) and DS-loaded p(N-isopropylacrylamide-co-acrylic acid) nanogels [p(NIPAM-co-AA) NGs, LCST2 ~40  C] acted as the dispersed phase.	Alginates	17-19	fibroblast growth factor 2	Homo sapiens	99-103
32962260-4	2020	Furthermore, the release kinetics of GLP-1 agonist drug from alginate-coated ZIF-8 were investigated in phosphate-buffered saline at 37  C at pH 8 and 1.5.	Alginates	61-69	glucagon	Homo sapiens	37-42
32416139-3	2020	We generated single- and double-mutant strains of ExsA (T3SS activator), AlgD (GDP- mannose 6-dehydrogenase of alginate biosynthesis) and their complemented strains and evaluated their pathogenicity in a rabbit ear full-thickness excision-wound infection model.	Alginates	111-119	GDP-mannose 6-dehydrogenase AlgD	Pseudomonas aeruginosa PAO1	73-77
32676953-0	2020	Hyaluronic Acid/Alginate Hydrogel Containing Hepatocyte Growth Factor and Promotion of Vocal Fold Wound Healing.	Alginates	16-24	hepatocyte growth factor	Oryctolagus cuniculus	45-69
32676953-2	2020	This study was undertaken to determine whether the therapeutic efficacy of HGF could be enhanced by applying it in hyaluronic acid and alginate (HA/ALG) composite hydrogels into VFs after injury in a rabbit model.	Alginates	135-143	hepatocyte growth factor	Oryctolagus cuniculus	75-78
32962260-1	2020	This work demonstrates synthetic strategies for the incorporation of a synthesized pyrimidine glucagon-like peptide-1 (GLP-1) agonist into alginate-coated ZIF-8.	Alginates	139-147	glucagon	Homo sapiens	94-117
32962260-1	2020	This work demonstrates synthetic strategies for the incorporation of a synthesized pyrimidine glucagon-like peptide-1 (GLP-1) agonist into alginate-coated ZIF-8.	Alginates	139-147	glucagon	Homo sapiens	119-124
32408161-3	2020	Herein, necklace-like Fe3O4/carbon nanofibril aerogel (Fe3O4/CNF) was constructed by crosslinking alginate with Fe3+, followed by carbonization of the obtained ferric alginate aerogel.	Alginates	98-106	NPHS1 adhesion molecule, nephrin	Homo sapiens	61-64
32688092-3	2020	The loading efficiency of growth factors into these biomaterials was found to be >90%, revealing a strong affinity of VEGF and BMP-2 to heparin and alginate.	Alginates	148-156	vascular endothelial growth factor A	Homo sapiens	118-122
32688092-3	2020	The loading efficiency of growth factors into these biomaterials was found to be >90%, revealing a strong affinity of VEGF and BMP-2 to heparin and alginate.	Alginates	148-156	bone morphogenetic protein 2	Homo sapiens	127-132
32962070-5	2020	The exterior of the hydrogels was made up of a rigid calcium alginate network that supported the entire hydrogel, promoting the stability of the vascular endothelial growth factor (VEGF) payload and controlling its release when the hydrogel was applied topically to wounds.	Alginates	53-69	vascular endothelial growth factor A	Homo sapiens	145-179
32962070-5	2020	The exterior of the hydrogels was made up of a rigid calcium alginate network that supported the entire hydrogel, promoting the stability of the vascular endothelial growth factor (VEGF) payload and controlling its release when the hydrogel was applied topically to wounds.	Alginates	53-69	vascular endothelial growth factor A	Homo sapiens	181-185
32339875-0	2020	Urea formaldehyde modified alginate beads with improved stability and enhanced removal of Pb2+, Cd2+, and Cu2.	Alginates	27-35	CD2 molecule	Homo sapiens	96-99
32428589-0	2020	Development of glucose oxidase-immobilized alginate nanoparticles for enhanced glucose-triggered insulin delivery in diabetic mice.	Alginates	43-51	hydroxyacid oxidase 1, liver	Mus musculus	15-30
32428589-1	2020	In this work, we successfully developed poly(acrylamido phenylboronic acid)/sodium alginate nanoparticles (NPs) via formation of cycloborates (glucose- and H2O2-responsive functional groups), as an improved glucose-mediated insulin delivery system loaded with glucose oxidase (GOx).	Alginates	76-91	hydroxyacid oxidase 1, liver	Mus musculus	260-275
32428589-1	2020	In this work, we successfully developed poly(acrylamido phenylboronic acid)/sodium alginate nanoparticles (NPs) via formation of cycloborates (glucose- and H2O2-responsive functional groups), as an improved glucose-mediated insulin delivery system loaded with glucose oxidase (GOx).	Alginates	76-91	hydroxyacid oxidase 1, liver	Mus musculus	277-280
32339875-6	2020	For example, the adsorption capacities of Pb2+, Cd2+, and Cu2+ on air-dried alginate-UF (1: 2.5) beads were 1.66, 0.61, and 0.80 mmol/g, which were 39.88%, 9.29%, and 9.52% higher than those of the corresponding unmodified alginate beads, respectively.	Alginates	76-84	CD2 molecule	Homo sapiens	48-51
33455293-5	2020	We further constructed recombinant bovine basic fibroblast growth factor (FGF-2) in fibrous alginate, which was encapsulated in antibiotic-loaded peptide hydrogel.	Alginates	92-100	fibroblast growth factor 2	Bos taurus	42-72
33455293-5	2020	We further constructed recombinant bovine basic fibroblast growth factor (FGF-2) in fibrous alginate, which was encapsulated in antibiotic-loaded peptide hydrogel.	Alginates	92-100	fibroblast growth factor 2	Bos taurus	74-79
32995677-0	2021	Release of VEGF and BMP9 from injectable alginate based composite hydrogel for treatment of myocardial infarction.	Alginates	41-49	vascular endothelial growth factor A	Homo sapiens	11-15
32995677-0	2021	Release of VEGF and BMP9 from injectable alginate based composite hydrogel for treatment of myocardial infarction.	Alginates	41-49	growth differentiation factor 2	Homo sapiens	20-24
32995677-3	2021	Aiming at the treatment of different stages of MI, in this work, an injectable alginate based composite hydrogel is developed to load vascular endothelial active factor (VEGF) and silk fibroin (SF) microspheres containing bone morphogenetic protein 9 (BMP9) for releasing VEGF and BMP9 to realize their respective functions.	Alginates	79-87	vascular endothelial growth factor A	Homo sapiens	170-174
32995677-3	2021	Aiming at the treatment of different stages of MI, in this work, an injectable alginate based composite hydrogel is developed to load vascular endothelial active factor (VEGF) and silk fibroin (SF) microspheres containing bone morphogenetic protein 9 (BMP9) for releasing VEGF and BMP9 to realize their respective functions.	Alginates	79-87	growth differentiation factor 2	Homo sapiens	222-250
32995677-3	2021	Aiming at the treatment of different stages of MI, in this work, an injectable alginate based composite hydrogel is developed to load vascular endothelial active factor (VEGF) and silk fibroin (SF) microspheres containing bone morphogenetic protein 9 (BMP9) for releasing VEGF and BMP9 to realize their respective functions.	Alginates	79-87	growth differentiation factor 2	Homo sapiens	252-256
32995677-3	2021	Aiming at the treatment of different stages of MI, in this work, an injectable alginate based composite hydrogel is developed to load vascular endothelial active factor (VEGF) and silk fibroin (SF) microspheres containing bone morphogenetic protein 9 (BMP9) for releasing VEGF and BMP9 to realize their respective functions.	Alginates	79-87	vascular endothelial growth factor A	Homo sapiens	272-276
32995677-3	2021	Aiming at the treatment of different stages of MI, in this work, an injectable alginate based composite hydrogel is developed to load vascular endothelial active factor (VEGF) and silk fibroin (SF) microspheres containing bone morphogenetic protein 9 (BMP9) for releasing VEGF and BMP9 to realize their respective functions.	Alginates	79-87	growth differentiation factor 2	Homo sapiens	281-285
32361537-1	2020	A series of alginate-derived porous graphitic carbon (PGC) wrapped iron-based organic frameworks (Fe-MIL-88B) composites were synthesized and checked their ability for the removal of arsenite (As(III)) and arsenate (As(V)) from water.	Alginates	12-20	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	215-221
32839325-4	2020	Specifically, in a cell-encapsulated alginate bead model, induced short hairpin (shRNA) knockdown or overexpression of MCT1 quantitatively inhibited or enhanced, respectively, unidirectional pyruvate influxes and [1-13C]pyruvate-to-[1-13C]lactate conversion rates, independent of glycolysis or LDHA activity.	Alginates	37-45	solute carrier family 16 member 1	Homo sapiens	119-123
32603868-6	2020	We observed that alginate conjugated with synthetic E-cadherin peptides not only supported initial cell attachment with high viability, but also supported hPSC propagation and high fold expansion.	Alginates	17-25	cadherin 1	Homo sapiens	52-62
32663663-0	2020	Alginate/laponite hydrogel microspheres co-encapsulating dental pulp stem cells and VEGF for endodontic regeneration.	Alginates	0-8	vascular endothelial growth factor A	Homo sapiens	84-88
32437076-6	2020	The cultures exposed to EGF in the alginate-based 3D microenvironment, showed the highest level of premeiotic (Oct4, Mvh), meiotic (Scp1, Scp3, Stra8, Rec8) and oocyte maturation (Gdf9, Cx37, Zp2) marker genes (P<0.05) in comparison to other groups.	Alginates	35-43	gap junction protein, alpha 4	Mus musculus	186-190
32437076-6	2020	The cultures exposed to EGF in the alginate-based 3D microenvironment, showed the highest level of premeiotic (Oct4, Mvh), meiotic (Scp1, Scp3, Stra8, Rec8) and oocyte maturation (Gdf9, Cx37, Zp2) marker genes (P<0.05) in comparison to other groups.	Alginates	35-43	zona pellucida glycoprotein 2	Mus musculus	192-195
32666184-5	2020	Deletion of the RIM15 gene, which regulates cell cycle progression according to nutritional status, hampered the cell cycle arrest observed in alginate-embedded cells, enhanced biofilm formation and improved fermentation ability.	Alginates	143-151	protein kinase RIM15	Saccharomyces cerevisiae S288C	16-21
32666184-7	2020	These findings suggest that the extracellular environment is mainly responsible for the difference between biofilm-based fermentation and alginate-embedded fermentation, and that RIM15 plays an essential role in cell cycle progression.	Alginates	138-146	protein kinase RIM15	Saccharomyces cerevisiae S288C	179-184
32437076-6	2020	The cultures exposed to EGF in the alginate-based 3D microenvironment, showed the highest level of premeiotic (Oct4, Mvh), meiotic (Scp1, Scp3, Stra8, Rec8) and oocyte maturation (Gdf9, Cx37, Zp2) marker genes (P<0.05) in comparison to other groups.	Alginates	35-43	epidermal growth factor	Mus musculus	24-27
32437076-6	2020	The cultures exposed to EGF in the alginate-based 3D microenvironment, showed the highest level of premeiotic (Oct4, Mvh), meiotic (Scp1, Scp3, Stra8, Rec8) and oocyte maturation (Gdf9, Cx37, Zp2) marker genes (P<0.05) in comparison to other groups.	Alginates	35-43	POU domain, class 5, transcription factor 1	Mus musculus	111-115
32437076-6	2020	The cultures exposed to EGF in the alginate-based 3D microenvironment, showed the highest level of premeiotic (Oct4, Mvh), meiotic (Scp1, Scp3, Stra8, Rec8) and oocyte maturation (Gdf9, Cx37, Zp2) marker genes (P<0.05) in comparison to other groups.	Alginates	35-43	DEAD box helicase 4	Mus musculus	117-120
32437076-6	2020	The cultures exposed to EGF in the alginate-based 3D microenvironment, showed the highest level of premeiotic (Oct4, Mvh), meiotic (Scp1, Scp3, Stra8, Rec8) and oocyte maturation (Gdf9, Cx37, Zp2) marker genes (P<0.05) in comparison to other groups.	Alginates	35-43	stem cell proliferation 1	Mus musculus	132-136
32437076-6	2020	The cultures exposed to EGF in the alginate-based 3D microenvironment, showed the highest level of premeiotic (Oct4, Mvh), meiotic (Scp1, Scp3, Stra8, Rec8) and oocyte maturation (Gdf9, Cx37, Zp2) marker genes (P<0.05) in comparison to other groups.	Alginates	35-43	synaptonemal complex protein 3	Mus musculus	138-142
32437076-6	2020	The cultures exposed to EGF in the alginate-based 3D microenvironment, showed the highest level of premeiotic (Oct4, Mvh), meiotic (Scp1, Scp3, Stra8, Rec8) and oocyte maturation (Gdf9, Cx37, Zp2) marker genes (P<0.05) in comparison to other groups.	Alginates	35-43	stimulated by retinoic acid gene 8	Mus musculus	144-149
32437076-6	2020	The cultures exposed to EGF in the alginate-based 3D microenvironment, showed the highest level of premeiotic (Oct4, Mvh), meiotic (Scp1, Scp3, Stra8, Rec8) and oocyte maturation (Gdf9, Cx37, Zp2) marker genes (P<0.05) in comparison to other groups.	Alginates	35-43	REC8 meiotic recombination protein	Mus musculus	151-155
32437076-6	2020	The cultures exposed to EGF in the alginate-based 3D microenvironment, showed the highest level of premeiotic (Oct4, Mvh), meiotic (Scp1, Scp3, Stra8, Rec8) and oocyte maturation (Gdf9, Cx37, Zp2) marker genes (P<0.05) in comparison to other groups.	Alginates	35-43	growth differentiation factor 9	Mus musculus	180-184
32634088-3	2020	The histone-like protein AlgP has previously been implicated in the control of alginate gene expression in mucoid strains, but this regulation is unclear.	Alginates	79-87	alginate regulatory protein AlgP	Pseudomonas aeruginosa PAO1	25-29
32781542-6	2020	LP-TP particles were also incorporated in an SA matrix via polymer crosslinking using CaCl2(aq) to improve the pH selective release.	Alginates	45-47	protein tyrosine phosphatase non-receptor type 7	Homo sapiens	0-5
32855655-0	2020	Alginate/Pluronic F127-based encapsulation supports viability and functionality of human dental pulp stem cell-derived insulin-producing cells.	Alginates	0-8	insulin	Homo sapiens	119-126
32438363-4	2020	The graft polymerization of EGMP on the surface of HAp was confirmed by the presence of 1732 cm-1 band which belongs to C=O stretching of EGMP, in addition to the characteristic peaks of nano HAp and alginate in the composite paste.	Alginates	200-208	BAG cochaperone 1	Homo sapiens	51-54
32438363-9	2020	Immunocytochemistry analysis revealed that addition of surface functionalized nano HAp and BMP2 to alginate hydrogel enhanced osteogenic potential of the prepared paste.	Alginates	99-107	BAG cochaperone 1	Homo sapiens	83-86
32438363-9	2020	Immunocytochemistry analysis revealed that addition of surface functionalized nano HAp and BMP2 to alginate hydrogel enhanced osteogenic potential of the prepared paste.	Alginates	99-107	bone morphogenetic protein 2	Homo sapiens	91-95
32867021-2	2020	Alkaline phosphatase (ALP) can modulate gel-sol transformation to increase the permeability of Cu2+-cross-linked alginate hydrogel film in the AHCS, followed by solution exchange into the capillary.	Alginates	113-121	alkaline phosphatase, placental	Homo sapiens	0-20
32867021-2	2020	Alkaline phosphatase (ALP) can modulate gel-sol transformation to increase the permeability of Cu2+-cross-linked alginate hydrogel film in the AHCS, followed by solution exchange into the capillary.	Alginates	113-121	alkaline phosphatase, placental	Homo sapiens	22-25
33014999-1	2020	Silk fibroin (SF) and sodium alginate (SA) are natural polymers used to produce biomaterials.	Alginates	22-37	acyl-CoA synthetase medium chain family member 3	Homo sapiens	39-41
32126729-0	2020	Pb(II) Adsorption of Composite Alginate Beads Containing Mesoporous Natural Zeolite.	Alginates	31-39	submaxillary gland androgen regulated protein 3B	Homo sapiens	0-6
32923589-7	2020	Injectable alginates functionalized with a1 and MMPQK (a vascular endothelial growth factor-mimetic peptide with a matrix metalloproteinase-degradable linker) increased blood perfusion and functional recovery over decellularized extracellular matrix and (RGDS + MMPQK)-functionalized hydrogels in an ischemic hindlimb model, illustrating the power of this approach.	Alginates	11-20	vascular endothelial growth factor A	Homo sapiens	57-91
33463325-3	2020	We report a marine derived oxidized alginate, alginate dialdehyde (ADA), and gelatin (GEL) system (ADA-GEL), which is cross-linked via ionic (Ca2+) and enzymatic (microbial transglutaminase, mTG) interaction to form dually cross-linked hydrogels.	Alginates	36-44	protease, serine 3	Mus musculus	191-194
32742480-6	2020	CD31 immunohistochemistry and alginate encapsulation experiments showed tumor angiogenesis were inhibited in MSCs-IL10 group in comparison to the control and vector group (P < 0.001), FITC-labeled dextran intake was also lower than the other groups (P < 0.01).	Alginates	30-38	interleukin 10	Homo sapiens	114-118
32475548-2	2020	Since the scavenger receptor-A (SR-A) on TAMs can recognize polyanions, two molecular-weight sodium alginates (SA1, 41.2 kDa; SA2, 1231.5 kDa) were herein respectively conjugated with 1-[4-(2-aminoethyl) phenoxy] zinc (II) phthalocyanine (1) and two novel conjugates were obtained, characterized and evaluated for their TAMs-targeted PDT efficacy.	Alginates	93-109	macrophage scavenger receptor 1	Homo sapiens	10-30
32475548-2	2020	Since the scavenger receptor-A (SR-A) on TAMs can recognize polyanions, two molecular-weight sodium alginates (SA1, 41.2 kDa; SA2, 1231.5 kDa) were herein respectively conjugated with 1-[4-(2-aminoethyl) phenoxy] zinc (II) phthalocyanine (1) and two novel conjugates were obtained, characterized and evaluated for their TAMs-targeted PDT efficacy.	Alginates	93-109	macrophage scavenger receptor 1	Homo sapiens	32-36
32923589-7	2020	Injectable alginates functionalized with a1 and MMPQK (a vascular endothelial growth factor-mimetic peptide with a matrix metalloproteinase-degradable linker) increased blood perfusion and functional recovery over decellularized extracellular matrix and (RGDS + MMPQK)-functionalized hydrogels in an ischemic hindlimb model, illustrating the power of this approach.	Alginates	11-20	ral guanine nucleotide dissociation stimulator	Homo sapiens	255-259
32545286-0	2020	BSA- and Elastin-Coated GO, but Not Collagen-Coated GO, Enhance the Biological Performance of Alginate Hydrogels.	Alginates	94-102	elastin	Homo sapiens	9-16
32664213-5	2020	The exposure to a tyramine solution of tyrosinase-loaded alginate spheres, or films deposited on glass or polyethylene, resulted in a rapid gel-confined psi-PDA formation with no leakage or darkening of the solution, allowing the complete recovery and re-utilization of the unreacted tyramine.	Alginates	57-65	tyrosinase	Homo sapiens	39-49
32578533-4	2020	We demonstrated sequential modification of alginate with first sulfate moieties to mimic the high glycosaminoglycan content of native cartilage and then tyramine moieties to allow in situ enzymatic crosslinking with tyrosinase under physiological conditions.	Alginates	43-51	tyrosinase	Homo sapiens	216-226
32663712-2	2020	In this study, a simple approach was reported to prepare MoS2 and glucose oxidase (GOx)-containing sodium alginate (ALG)-Fe3+ (MAF) hydrogel.	Alginates	99-114	hydroxyacid oxidase 1	Homo sapiens	66-81
32663712-2	2020	In this study, a simple approach was reported to prepare MoS2 and glucose oxidase (GOx)-containing sodium alginate (ALG)-Fe3+ (MAF) hydrogel.	Alginates	99-114	hydroxyacid oxidase 1	Homo sapiens	83-86
32663712-2	2020	In this study, a simple approach was reported to prepare MoS2 and glucose oxidase (GOx)-containing sodium alginate (ALG)-Fe3+ (MAF) hydrogel.	Alginates	99-114	MAF bZIP transcription factor	Homo sapiens	127-130
32663712-2	2020	In this study, a simple approach was reported to prepare MoS2 and glucose oxidase (GOx)-containing sodium alginate (ALG)-Fe3+ (MAF) hydrogel.	Alginates	116-119	hydroxyacid oxidase 1	Homo sapiens	66-81
32663712-2	2020	In this study, a simple approach was reported to prepare MoS2 and glucose oxidase (GOx)-containing sodium alginate (ALG)-Fe3+ (MAF) hydrogel.	Alginates	116-119	hydroxyacid oxidase 1	Homo sapiens	83-86
32663712-2	2020	In this study, a simple approach was reported to prepare MoS2 and glucose oxidase (GOx)-containing sodium alginate (ALG)-Fe3+ (MAF) hydrogel.	Alginates	116-119	MAF bZIP transcription factor	Homo sapiens	127-130
32579062-3	2021	Using a combination of molecular modeling and simulation techniques, in this study the effects of five carbohydrate polymers of Chitosan, Alginate, Cyclodextrin, Hyaluronic acid and Pectin on structure and dynamics of interleukin2 protein at 298 K and 343 K, are investigated.	Alginates	138-146	interleukin 2	Homo sapiens	218-230
32575684-0	2020	Controlled Delivery of Insulin-like Growth Factor-1 from Bioactive Glass-Incorporated Alginate-Poloxamer/Silk Fibroin Hydrogels.	Alginates	86-94	insulin like growth factor 1	Homo sapiens	23-51
32545286-6	2020	In the current research, we aim to study several proteins, specifically bovine serum albumin (BSA), type I collagen and elastin, to discern their impact on the previously observed improvement on embedded myoblasts within alginate hydrogels containing GO coated with FBS.	Alginates	221-229	albumin	Homo sapiens	79-92
32545286-6	2020	In the current research, we aim to study several proteins, specifically bovine serum albumin (BSA), type I collagen and elastin, to discern their impact on the previously observed improvement on embedded myoblasts within alginate hydrogels containing GO coated with FBS.	Alginates	221-229	elastin	Homo sapiens	120-127
33463166-0	2020	Alginate Affects Bioactivity of Chimeric Collagen-Binding LL37 Antimicrobial Peptides Adsorbed to Collagen-Alginate Wound Dressings.	Alginates	0-8	cathelicidin antimicrobial peptide	Homo sapiens	58-62
33463166-0	2020	Alginate Affects Bioactivity of Chimeric Collagen-Binding LL37 Antimicrobial Peptides Adsorbed to Collagen-Alginate Wound Dressings.	Alginates	107-115	cathelicidin antimicrobial peptide	Homo sapiens	58-62
33463166-7	2020	The goal of this study was to investigate how the presence of alginate affects the tethering, release, and antimicrobial activity of LL37 and CBD-LL37 peptides adsorbed to commercially available collagen-alginate wound dressings (FIBRACOL Plus-a 90% collagen and 10% alginate wound dressing).	Alginates	62-70	cathelicidin antimicrobial peptide	Homo sapiens	133-137
33463166-7	2020	The goal of this study was to investigate how the presence of alginate affects the tethering, release, and antimicrobial activity of LL37 and CBD-LL37 peptides adsorbed to commercially available collagen-alginate wound dressings (FIBRACOL Plus-a 90% collagen and 10% alginate wound dressing).	Alginates	62-70	cathelicidin antimicrobial peptide	Homo sapiens	146-150
33463166-7	2020	The goal of this study was to investigate how the presence of alginate affects the tethering, release, and antimicrobial activity of LL37 and CBD-LL37 peptides adsorbed to commercially available collagen-alginate wound dressings (FIBRACOL Plus-a 90% collagen and 10% alginate wound dressing).	Alginates	204-212	cathelicidin antimicrobial peptide	Homo sapiens	133-137
33463166-7	2020	The goal of this study was to investigate how the presence of alginate affects the tethering, release, and antimicrobial activity of LL37 and CBD-LL37 peptides adsorbed to commercially available collagen-alginate wound dressings (FIBRACOL Plus-a 90% collagen and 10% alginate wound dressing).	Alginates	204-212	cathelicidin antimicrobial peptide	Homo sapiens	146-150
33463166-7	2020	The goal of this study was to investigate how the presence of alginate affects the tethering, release, and antimicrobial activity of LL37 and CBD-LL37 peptides adsorbed to commercially available collagen-alginate wound dressings (FIBRACOL Plus-a 90% collagen and 10% alginate wound dressing).	Alginates	204-212	cathelicidin antimicrobial peptide	Homo sapiens	133-137
33463166-7	2020	The goal of this study was to investigate how the presence of alginate affects the tethering, release, and antimicrobial activity of LL37 and CBD-LL37 peptides adsorbed to commercially available collagen-alginate wound dressings (FIBRACOL Plus-a 90% collagen and 10% alginate wound dressing).	Alginates	204-212	cathelicidin antimicrobial peptide	Homo sapiens	146-150
33463166-10	2020	The presence of alginate in solution induced conformational changes in the cCBD-LL37 and LL37 peptides, resulting in increased peptide helicity, and reduced antimicrobial activity against P. aeruginosa.	Alginates	16-24	cathelicidin antimicrobial peptide	Homo sapiens	80-84
33463166-10	2020	The presence of alginate in solution induced conformational changes in the cCBD-LL37 and LL37 peptides, resulting in increased peptide helicity, and reduced antimicrobial activity against P. aeruginosa.	Alginates	16-24	cathelicidin antimicrobial peptide	Homo sapiens	89-93
32255552-5	2020	Preweaned porcine islets are encapsulated in peptide-functionalized alginate microcapsules, and those encapsulated in RGD-functionalized alginate displays enhanced viability and glucose-stimulated insulin release.	Alginates	137-145	insulin	Homo sapiens	197-204
32419390-6	2020	Here, it is reported that alginate microcapsules loaded with processed conditioned media (pCM-Alg) reduces the infiltration and/or expression of CD68+ macrophages likely through the controlled release of pCM.	Alginates	26-34	CD68 molecule	Homo sapiens	145-149
32419390-7	2020	In vitro cultures revealed that alginate can dose dependently induce macrophages to secrete TNFalpha, IL-6, IL-1beta, and GM-CSF.	Alginates	32-40	tumor necrosis factor	Homo sapiens	92-100
32419390-7	2020	In vitro cultures revealed that alginate can dose dependently induce macrophages to secrete TNFalpha, IL-6, IL-1beta, and GM-CSF.	Alginates	32-40	interleukin 6	Homo sapiens	102-106
32419390-7	2020	In vitro cultures revealed that alginate can dose dependently induce macrophages to secrete TNFalpha, IL-6, IL-1beta, and GM-CSF.	Alginates	32-40	interleukin 1 alpha	Homo sapiens	108-116
32419390-7	2020	In vitro cultures revealed that alginate can dose dependently induce macrophages to secrete TNFalpha, IL-6, IL-1beta, and GM-CSF.	Alginates	32-40	colony stimulating factor 2	Homo sapiens	122-128
32419390-8	2020	Addition of pCM to the cultures attenuates the secretion of TNFalpha (p = 0.023) and IL-6 (p < 0.0001) by alginate or lipopolysaccharide (LPS) stimulations.	Alginates	106-114	tumor necrosis factor	Homo sapiens	60-68
32419390-8	2020	Addition of pCM to the cultures attenuates the secretion of TNFalpha (p = 0.023) and IL-6 (p < 0.0001) by alginate or lipopolysaccharide (LPS) stimulations.	Alginates	106-114	interleukin 6	Homo sapiens	85-89
32389652-3	2020	The developed alginate/polyacrylate beads were collaboratively characterized by FT-IR, TGA, SEM, XPS, etc., and various adsorption conditions were tested including the pH of the solution, contact time and the initial concentration.	Alginates	14-22	T-box transcription factor 1	Homo sapiens	87-90
32387601-0	2020	Epidermal growth factor receptor conjugated fucoidan/alginates loaded hydrogel for activating EGFR/AKT signaling pathways in colon cancer cells during targeted photodynamic therapy.	Alginates	53-62	epidermal growth factor receptor	Homo sapiens	0-32
32387601-0	2020	Epidermal growth factor receptor conjugated fucoidan/alginates loaded hydrogel for activating EGFR/AKT signaling pathways in colon cancer cells during targeted photodynamic therapy.	Alginates	53-62	epidermal growth factor receptor	Homo sapiens	94-98
32387601-0	2020	Epidermal growth factor receptor conjugated fucoidan/alginates loaded hydrogel for activating EGFR/AKT signaling pathways in colon cancer cells during targeted photodynamic therapy.	Alginates	53-62	AKT serine/threonine kinase 1	Homo sapiens	99-102
32387601-1	2020	In the present study, we developed epidermal growth factor receptor conjugated fucoidan/alginate loaded hydrogels for targeting the delivery of hydrogel through the signaling pathway of the epidermal growth factor receptor (EGFR) to treat colon cancer.	Alginates	88-96	epidermal growth factor receptor	Homo sapiens	35-67
32387601-1	2020	In the present study, we developed epidermal growth factor receptor conjugated fucoidan/alginate loaded hydrogels for targeting the delivery of hydrogel through the signaling pathway of the epidermal growth factor receptor (EGFR) to treat colon cancer.	Alginates	88-96	epidermal growth factor receptor	Homo sapiens	190-222
32387601-1	2020	In the present study, we developed epidermal growth factor receptor conjugated fucoidan/alginate loaded hydrogels for targeting the delivery of hydrogel through the signaling pathway of the epidermal growth factor receptor (EGFR) to treat colon cancer.	Alginates	88-96	epidermal growth factor receptor	Homo sapiens	224-228
32259804-6	2020	In a pre-clinical in vivo application of a nanoclay-based bioink to regenerate skeletal tissue, we demonstrated bone morphogenetic protein-2 (BMP-2) absorbed scaffolds produced extensive mineralisation after 4 weeks (p<0.0001) compared to the drug-free and alginate controls.	Alginates	257-265	bone morphogenetic protein 2	Homo sapiens	112-140
32259804-6	2020	In a pre-clinical in vivo application of a nanoclay-based bioink to regenerate skeletal tissue, we demonstrated bone morphogenetic protein-2 (BMP-2) absorbed scaffolds produced extensive mineralisation after 4 weeks (p<0.0001) compared to the drug-free and alginate controls.	Alginates	257-265	bone morphogenetic protein 2	Homo sapiens	142-147
32355267-0	2020	Development of a polyvinyl alcohol/sodium alginate hydrogel-based scaffold incorporating bFGF-encapsulated microspheres for accelerated wound healing.	Alginates	35-50	fibroblast growth factor 2	Rattus norvegicus	89-93
32169893-3	2020	The delivery of the G3c mAb via G3C hybridoma cells enveloped in alginate-based microcapsules (G3C/cps) for 3 weeks induced Foxp3+ Treg cell expansion in the spleen of wild-type mice but not in Gitr-/- mice.	Alginates	65-73	forkhead box P3	Mus musculus	124-129
32169893-3	2020	The delivery of the G3c mAb via G3C hybridoma cells enveloped in alginate-based microcapsules (G3C/cps) for 3 weeks induced Foxp3+ Treg cell expansion in the spleen of wild-type mice but not in Gitr-/- mice.	Alginates	65-73	tumor necrosis factor receptor superfamily, member 18	Mus musculus	194-198
32204114-0	2020	Encapsulation of green tea polyphenol nanospheres in PVA/alginate hydrogel for promoting wound healing of diabetic rats by regulating PI3K/AKT pathway.	Alginates	57-65	AKT serine/threonine kinase 1	Rattus norvegicus	139-142
32384447-12	2020	As for the DDS particle neurotoxicity, a 95% cell viability was noticed after alginate-encapsulated MNPs treatment and a 93% cell viability after DDS treatment, compared with the control.The DDS-EPO construct developed here can be small under in vivo conditions enough to pass through the lung capillaries with showing the high coating efficiency.	Alginates	78-86	erythropoietin	Homo sapiens	195-198
32353495-3	2020	We found that the administration of both F or SA resulted in a beneficial effect by significantly decreasing lead levels (p < 0.05) in the kidneys from 2.85 mg/kg to 0.79 mg/kg and improving antioxidant status (SOD, GSH, and CAT) thereby alleviating lead-induced damage and injury of the liver and kidneys (AST, BUN, and Cr).	Alginates	46-48	catalase	Rattus norvegicus	225-228
32295255-0	2020	Characterization and Mathematical Modeling of Alginate/Chitosan-Based Nanoparticles Releasing the Chemokine CXCL12 to Attract Glioblastoma Cells.	Alginates	46-54	C-X-C motif chemokine ligand 12	Rattus norvegicus	108-114
32314017-0	2020	A chemiluminescence assay for determination of lysozyme based on the use of magnetic alginate-aptamer composition and hemin@HKUST-1.	Alginates	85-93	lysozyme	Homo sapiens	47-55
32314017-15	2020	Lysozyme (Lys) was captured by aptamer-modified magnetic sodium alginate (M-Alg-Apt); Glycine (pH = 2) as eluent for Lys.	Alginates	57-72	lysozyme	Homo sapiens	0-8
32341778-0	2020	Alginate-encapsulated brain-derived neurotrophic factor-overexpressing mesenchymal stem cells are a promising drug delivery system for protection of auditory neurons.	Alginates	0-8	brain-derived neurotrophic factor	Rattus norvegicus	22-55
32341778-10	2020	Local drug delivery by ultra-high viscous-alginate-encapsulated brain-derived neurotrophic factor-overexpressing mesenchymal stem cells is a promising strategy to improve the cochlear implant outcome.	Alginates	42-50	brain-derived neurotrophic factor	Rattus norvegicus	64-97
32295255-1	2020	Chitosan (Chit) currently used to prepare nanoparticles (NPs) for brain application can be complexed with negatively charged polymers such as alginate (Alg) to better entrap positively charged molecules such as CXCL12.	Alginates	142-150	C-X-C motif chemokine ligand 12	Rattus norvegicus	211-217
32295255-1	2020	Chitosan (Chit) currently used to prepare nanoparticles (NPs) for brain application can be complexed with negatively charged polymers such as alginate (Alg) to better entrap positively charged molecules such as CXCL12.	Alginates	152-155	C-X-C motif chemokine ligand 12	Rattus norvegicus	211-217
31952203-2	2020	Here, we report the synthesis of nanocomposites for the oral delivery of insulin composed of alginate, dextran sulfate, poly-(ethylene glycol) 4000, poloxamer 188, chitosan, and bovine serum albumin.	Alginates	93-101	insulin	Homo sapiens	73-80
32298378-8	2020	Immunization of BALB/c mice with alginate-encapsulated BoDeltaabcBA (108 CFU) induced lymphocyte proliferation, production of IL-10 and IFN-gamma, and protected against experimental challenge with B. canis.	Alginates	33-41	interleukin 10	Mus musculus	126-131
32298378-8	2020	Immunization of BALB/c mice with alginate-encapsulated BoDeltaabcBA (108 CFU) induced lymphocyte proliferation, production of IL-10 and IFN-gamma, and protected against experimental challenge with B. canis.	Alginates	33-41	interferon gamma	Mus musculus	136-145
32276508-0	2020	Improved Diabetic Wound Healing by EGF Encapsulation in Gelatin-Alginate Coacervates.	Alginates	64-72	epidermal growth factor	Mus musculus	35-38
32276508-2	2020	In this study, we selected a complex coacervate (EGF-Coa) composed of the low molecular weight gelatin type A and sodium alginate as a novel delivery system for EGF, based on encapsulation efficiency and protection of EGF from protease.	Alginates	114-129	epidermal growth factor	Mus musculus	49-52
32276508-2	2020	In this study, we selected a complex coacervate (EGF-Coa) composed of the low molecular weight gelatin type A and sodium alginate as a novel delivery system for EGF, based on encapsulation efficiency and protection of EGF from protease.	Alginates	114-129	epidermal growth factor	Mus musculus	161-164
32276508-8	2020	We propose low molecular weight gelatin type A and sodium alginate (LWGA-SA) coacervates as a novel EGF delivery system with enhanced efficacy for chronic wounds.	Alginates	51-66	epidermal growth factor	Mus musculus	100-103
32318563-7	2020	Unloaded and CSF-1/IL4 loaded alginate gel formulations have been implanted in skin flap ischemic wounds to test the safety and efficacy of the delivery system in vivo.	Alginates	30-38	interleukin 4	Rattus norvegicus	19-22
32163080-0	2020	The inhibitory activity of alginate against allergic reactions in an ovalbumin-induced mouse model.	Alginates	27-35	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	69-78
32163080-4	2020	The ability of alginate to inhibit allergic reactions was investigated in ovalbumin (OVA)-induced BALB/c mice, which have been widely used as a mouse model of egg allergy.	Alginates	15-23	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	74-83
32163080-5	2020	The results showed that alginate could effectively attenuate the occurrence of allergic reactions, including improving the integrity of the intestinal epithelial villi and inhibition of mast cell degranulation in the jejunum, in OVA-induced mice.	Alginates	24-32	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	229-232
32163080-6	2020	Moreover, after treatment with alginate, the levels of IgE, histamine and IL-4 in OVA-induced mice were remarkably decreased, and the levels of IFN-gamma were markedly increased.	Alginates	31-39	interleukin 4	Mus musculus	74-78
32163080-6	2020	Moreover, after treatment with alginate, the levels of IgE, histamine and IL-4 in OVA-induced mice were remarkably decreased, and the levels of IFN-gamma were markedly increased.	Alginates	31-39	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	82-85
32163080-6	2020	Moreover, after treatment with alginate, the levels of IgE, histamine and IL-4 in OVA-induced mice were remarkably decreased, and the levels of IFN-gamma were markedly increased.	Alginates	31-39	interferon gamma	Mus musculus	144-153
32163080-7	2020	In addition, the number of Treg cells in spleen tissues in OVA-induced mice was increased by alginate, and the OVA-induced differentiation of Th0 cells into Th2 cells was significantly inhibited.	Alginates	93-101	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	59-62
33455396-7	2020	The incorporation of alginate also enhanced the mechanical performance of the soft covalent network by forming reversible alginate-Ca2+ ionic cross-links, which interpenetrate through the outer water-retention scaffold with delicate weblike structures.	Alginates	21-29	POC1 centriolar protein A	Homo sapiens	78-82
33455396-7	2020	The incorporation of alginate also enhanced the mechanical performance of the soft covalent network by forming reversible alginate-Ca2+ ionic cross-links, which interpenetrate through the outer water-retention scaffold with delicate weblike structures.	Alginates	122-130	POC1 centriolar protein A	Homo sapiens	78-82
33464873-0	2020	Correction to "Alginate Enhances Memory Properties of Antitumor CD8+ T Cells by Promoting Cellular Antioxidation".	Alginates	15-23	CD8a molecule	Homo sapiens	64-67
32050432-3	2020	This study involved complexation of two negatively charged bio-polymers xanthan and alginate with clinically-relevant insulin degludec (PIC).	Alginates	84-92	insulin	Homo sapiens	118-125
31826469-0	2020	Promoted chondrogenesis of hMCSs with controlled release of TGF-beta3 via microfluidics synthesized alginate nanogels.	Alginates	100-108	transforming growth factor beta 3	Homo sapiens	60-69
31826469-3	2020	Here, we proposed an on-chip hydrodynamic flow focusing microfluidic approach for synthesis of alginate nanogels loaded with the transforming growth factor beta 3 (TGF-beta3) through an ionic gelation method in order to achieve precise release profile of these bioactive agents during chondrogenic differentiation of mesenchymal stem cells (MSCs).	Alginates	95-103	transforming growth factor beta 3	Homo sapiens	129-162
31826469-3	2020	Here, we proposed an on-chip hydrodynamic flow focusing microfluidic approach for synthesis of alginate nanogels loaded with the transforming growth factor beta 3 (TGF-beta3) through an ionic gelation method in order to achieve precise release profile of these bioactive agents during chondrogenic differentiation of mesenchymal stem cells (MSCs).	Alginates	95-103	transforming growth factor beta 3	Homo sapiens	164-173
31958554-4	2020	In this paper, silver nanoparticles (AgNPs) were reduced by in situ reduction with sodium alginate (SA), and construct a silver-loaded PVA/SA/CMCS hydrogel antibacterial wound dressing.	Alginates	83-98	G protein signaling modulator 2	Homo sapiens	142-146
31958554-4	2020	In this paper, silver nanoparticles (AgNPs) were reduced by in situ reduction with sodium alginate (SA), and construct a silver-loaded PVA/SA/CMCS hydrogel antibacterial wound dressing.	Alginates	100-102	G protein signaling modulator 2	Homo sapiens	142-146
31726158-0	2020	Adsorption of Cr(III) and Pb(II) by graphene oxide/alginate hydrogel membrane: Characterization, adsorption kinetics, isotherm and thermodynamics studies.	Alginates	51-59	submaxillary gland androgen regulated protein 3B	Homo sapiens	26-32
31910350-0	2020	HGF Gene Delivering Alginate/Galactosylated Chitosan Sponge Scaffold for Three-Dimensional Coculture of Hepatocytes/3T3 Cells.	Alginates	20-28	hepatocyte growth factor	Mus musculus	0-3
31910350-2	2020	In this study, a hepatocyte growth factor plasmid/polyetherimide (pHGF/PEI) polyplex delivering alginate (AL)/galactosylated chitosan (GC) (pHGF/PEI-AL/GC) sponge scaffold was prepared for the in vitro coculture of hepatocytes/3T3 cells.	Alginates	96-104	hepatocyte growth factor	Mus musculus	17-41
31910350-2	2020	In this study, a hepatocyte growth factor plasmid/polyetherimide (pHGF/PEI) polyplex delivering alginate (AL)/galactosylated chitosan (GC) (pHGF/PEI-AL/GC) sponge scaffold was prepared for the in vitro coculture of hepatocytes/3T3 cells.	Alginates	106-108	hepatocyte growth factor	Mus musculus	17-41
31910350-2	2020	In this study, a hepatocyte growth factor plasmid/polyetherimide (pHGF/PEI) polyplex delivering alginate (AL)/galactosylated chitosan (GC) (pHGF/PEI-AL/GC) sponge scaffold was prepared for the in vitro coculture of hepatocytes/3T3 cells.	Alginates	149-151	hepatocyte growth factor	Mus musculus	17-41
31910350-5	2020	Furthermore, the albumin secretion and urea synthesis of hepatocytes were significantly enhanced when cocultured with 3T3 cells in the pHGF/PEI-AL/GC sponge scaffold compared with that in the AL/GC sponge without pHGF.	Alginates	144-146	albumin	Mus musculus	17-24
32252155-3	2020	METHODS: NP cells cultured in alginate beads were activated with IL-1beta +- the COX-2 inhibitor Sc-58125.	Alginates	30-38	interleukin 1 alpha	Homo sapiens	65-73
32252155-3	2020	METHODS: NP cells cultured in alginate beads were activated with IL-1beta +- the COX-2 inhibitor Sc-58125.	Alginates	30-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	81-86
31376330-8	2020	The expression of Cyp19a1 and Lhcgr in CS group was significantly higher than that of the alginate group (P&lt;=0.05).	Alginates	90-98	cytochrome P450, family 19, subfamily a, polypeptide 1	Mus musculus	18-25
31808500-0	2020	Sustained release of bioactive IGF-1 from a silk fibroin microsphere-based injectable alginate hydrogel for the treatment of myocardial infarction.	Alginates	86-94	insulin like growth factor 1	Homo sapiens	31-36
31808500-2	2020	In this work, an injectable alginate hydrogel containing silk fibroin (SF) microspheres with the capability to sustain the release of IGF-1 was prepared to induce myocardial repair after myocardial infarction (MI).	Alginates	28-36	insulin like growth factor 1	Homo sapiens	134-139
31449332-4	2019	Hence, alginate systems can be used as an alternative to ionic surfactants in CLA immobilization.	Alginates	7-15	selectin P ligand	Homo sapiens	78-81
31449332-5	2019	This paper presents, for the first time, the use of sodium alginate as potential ligand for enhanced CLA immobilization.	Alginates	52-67	selectin P ligand	Homo sapiens	101-104
31449332-6	2019	The use of five model proteins; lysozyme, bovine serum albumin, ovalbumin, insulin, and alpha-chymotrypsin, of various pIs and hydrophobicities, showed the relevance of electrostatic interactions in promoting binding with sodium alginate when the pH &lt; pI, with 100% immobilization attributed to alginate incorporated CLAs over general nonionic formulations.	Alginates	222-237	albumin	Homo sapiens	49-93
31449332-6	2019	The use of five model proteins; lysozyme, bovine serum albumin, ovalbumin, insulin, and alpha-chymotrypsin, of various pIs and hydrophobicities, showed the relevance of electrostatic interactions in promoting binding with sodium alginate when the pH &lt; pI, with 100% immobilization attributed to alginate incorporated CLAs over general nonionic formulations.	Alginates	229-237	albumin	Homo sapiens	49-93
31765673-4	2019	Biocompatible alginate-based cryogels containing bone morphogenetic proteins (BMP-2) and the Notch ligand Dll4 were engineered to recapitulate the endogenous niche.	Alginates	14-22	bone morphogenetic protein 2	Mus musculus	78-83
33438588-6	2019	Injectable alginate hydrogel loaded with GDNF, thermoresponsives heparin-poloxamer loaded with NGF and imidazole-poly(organophosphazenes) hydrogels are just three examples of biomaterials that can promote neurite, axon growth and improve functional recovery in hemisected and resected rats.	Alginates	11-19	glial cell derived neurotrophic factor	Rattus norvegicus	41-45
31595890-11	2019	The cellular osteogenesis potential of the silicate/alginate scaffold was further proven by the enhanced expression of osteogenic genes (Col1a1, ALP and OCN).	Alginates	52-60	collagen type I alpha 1 chain	Rattus norvegicus	137-143
33405530-6	2019	Finally, animal experiments confirmed that oral administration of hydrogel (chitosan/alginate)-embedding SS molecules attenuated UC-induced symptoms (e.g., body weight loss, colon shortening, increase of spleen weight, and histopathological appearance), which was supported by signs of mucosal healing, anti-inflammation, and elevation of the amounts of tight junction proteins (occludin and zonula occludens-1) and mucin protein (MUC2).	Alginates	85-93	occludin	Mus musculus	379-387
33405530-6	2019	Finally, animal experiments confirmed that oral administration of hydrogel (chitosan/alginate)-embedding SS molecules attenuated UC-induced symptoms (e.g., body weight loss, colon shortening, increase of spleen weight, and histopathological appearance), which was supported by signs of mucosal healing, anti-inflammation, and elevation of the amounts of tight junction proteins (occludin and zonula occludens-1) and mucin protein (MUC2).	Alginates	85-93	mucin 2	Mus musculus	431-435
31612699-4	2019	The acoustic droplet dispenser is employed to generate oxidized alginate microdroplets containing the MMP-9 enzyme (OA-MMP-9) with controllable size and precise positioning upon the cell-attached GNP-chip, allowing controlled cell-surface biodegradation under enzymatic reactions followed by calcium chloride (CaCl2) solution treatment to form single-cell encapsulated calcium alginate hydrogels.	Alginates	64-72	matrix metallopeptidase 9	Homo sapiens	102-107
31472829-2	2019	Bovine serum albumin (BSA), which was chosen as a model protein, was loaded into surfactant modified calcium alginate beads (SDS/Ca-Alg).	Alginates	101-117	albumin	Homo sapiens	7-20
31612699-4	2019	The acoustic droplet dispenser is employed to generate oxidized alginate microdroplets containing the MMP-9 enzyme (OA-MMP-9) with controllable size and precise positioning upon the cell-attached GNP-chip, allowing controlled cell-surface biodegradation under enzymatic reactions followed by calcium chloride (CaCl2) solution treatment to form single-cell encapsulated calcium alginate hydrogels.	Alginates	369-385	matrix metallopeptidase 9	Homo sapiens	102-107
31401269-4	2019	Then, MCS/ZnO@Alg gel beads were fabricated by combining MCS with ZnO and Alg, and crosslinking the composite material in the presence of Ca2+ ions.	Alginates	14-17	Miles-Carpenter X-linked mental retardation syndrome	Homo sapiens	6-9
31400615-0	2019	Controlled release of lysozyme based core/shells structured alginate beads with CaCO3 microparticles using Pickering emulsion template and in situ gelation.	Alginates	60-68	lysozyme	Homo sapiens	22-30
30923857-4	2019	In the present study, we aimed to repair the defective cracks with a calcium alginate (CaAlg) hydrogel containing bone morphogenetic protein 4 (BMP4)-enhanced adipose-derived stem cells (ADSCs).	Alginates	69-85	bone morphogenetic protein 4	Sus scrofa	114-142
30923857-4	2019	In the present study, we aimed to repair the defective cracks with a calcium alginate (CaAlg) hydrogel containing bone morphogenetic protein 4 (BMP4)-enhanced adipose-derived stem cells (ADSCs).	Alginates	69-85	bone morphogenetic protein 4	Sus scrofa	144-148
30923857-4	2019	In the present study, we aimed to repair the defective cracks with a calcium alginate (CaAlg) hydrogel containing bone morphogenetic protein 4 (BMP4)-enhanced adipose-derived stem cells (ADSCs).	Alginates	87-92	bone morphogenetic protein 4	Sus scrofa	114-142
30923857-4	2019	In the present study, we aimed to repair the defective cracks with a calcium alginate (CaAlg) hydrogel containing bone morphogenetic protein 4 (BMP4)-enhanced adipose-derived stem cells (ADSCs).	Alginates	87-92	bone morphogenetic protein 4	Sus scrofa	144-148
31655203-3	2019	Due to the cooperation of alginate and Tat peptide, Alg-Tat-gp100 demonstrated the significant improvement of stability in the stomach, mucus penetration ability in intestine, and transport across mucus layer and MDCK cells.	Alginates	26-34	tyrosine aminotransferase	Canis lupus familiaris	56-59
31655203-3	2019	Due to the cooperation of alginate and Tat peptide, Alg-Tat-gp100 demonstrated the significant improvement of stability in the stomach, mucus penetration ability in intestine, and transport across mucus layer and MDCK cells.	Alginates	26-34	premelanosome protein	Mus musculus	60-65
31401269-4	2019	Then, MCS/ZnO@Alg gel beads were fabricated by combining MCS with ZnO and Alg, and crosslinking the composite material in the presence of Ca2+ ions.	Alginates	14-17	Miles-Carpenter X-linked mental retardation syndrome	Homo sapiens	57-60
31401269-5	2019	The MCS/ZnO@Alg beads were characterized by SEM, FTIR spectroscopy, XRD, VSM, and XPS.	Alginates	12-15	Miles-Carpenter X-linked mental retardation syndrome	Homo sapiens	4-7
31401269-9	2019	This work proves that the MCS/ZnO@Alg gel beads are an ideal candidate for addressing the grievous environmental threats caused by water pollution.	Alginates	34-37	Miles-Carpenter X-linked mental retardation syndrome	Homo sapiens	26-29
31421199-0	2019	Applications of alginate microspheres in therapeutics delivery and cell culture: Past, present and future.	Alginates	16-24	EH domain containing 1	Homo sapiens	81-85
31505927-3	2019	Two types of bioactive molecules (bovine serum albumin and catalase) can be encapsulated with high efficiency (>85%) because of the partitioning effect of the ATPS and high viscosity of alginate solution.	Alginates	186-194	catalase	Homo sapiens	59-67
31081347-0	2019	Alginate-coated chitosan microparticles encapsulating an oral plasmid-cured live Salmonella enterica serovar Gallinarum vaccine cause a higher expression of interferon-gamma in chickens compared to the parenteral live vaccine.	Alginates	0-8	interferon gamma	Gallus gallus	157-173
31081347-12	2019	In conclusion, the IFN-gamma was more highly expressed in the PC group (though not significantly higher) compared to the SC and VM groups and this could be attributed to the alginate-coated chitosan microparticles which acted as an adjuvant.	Alginates	174-182	interferon gamma	Gallus gallus	19-28
31351956-0	2019	Mucin immobilization in calcium alginate: A possible mucus mimetic tool for evaluating mucoadhesion and retention of flavour.	Alginates	24-40	mucin 1, cell surface associated	Bos taurus	0-5
31407727-6	2019	An increase in the DS of alginates resulted in augmented FGF-2 binding as evidenced by higher frequency and dissipation shifts measured with QCM-D and confirmed with immunostaining.	Alginates	25-34	fibroblast growth factor 2	Rattus norvegicus	57-62
31351956-2	2019	Here, a mucus-mimetic platform was developed through a one-step approach based on encapsulating mucin within alginate gel beads.	Alginates	109-117	mucin 1, cell surface associated	Bos taurus	96-101
31351956-6	2019	The alginate-mucin mucus mimic was validated using an ex-vivo bovine tongue, with the flavour retention results showing qualitative agreement.	Alginates	4-12	mucin 1, cell surface associated	Bos taurus	13-18
31387086-3	2019	In this study, we incorporated two concentrations of alginate lyase (0.5 mU ml-1 and 5 mU ml-1) into alginate/gelatin bioink to improve its degradation properties and effects on cellular behavior.	Alginates	53-61	interleukin 17F	Homo sapiens	76-80
31387086-3	2019	In this study, we incorporated two concentrations of alginate lyase (0.5 mU ml-1 and 5 mU ml-1) into alginate/gelatin bioink to improve its degradation properties and effects on cellular behavior.	Alginates	53-61	interleukin 17F	Homo sapiens	90-94
31387086-3	2019	In this study, we incorporated two concentrations of alginate lyase (0.5 mU ml-1 and 5 mU ml-1) into alginate/gelatin bioink to improve its degradation properties and effects on cellular behavior.	Alginates	101-109	interleukin 17F	Homo sapiens	90-94
31497467-5	2019	4 x 106 cells mL-1 was entrapped in 3% (W/V) of alginate bead of size 2 mm each at a temperature of 30  C and pH of 6.	Alginates	48-56	L1 cell adhesion molecule	Mus musculus	14-18
31527490-5	2019	The alginate nanospheres were prepared via a combination of water-in-oil emulsification and the external gelation method and loaded with bovine serum albumin (BSA) as a model protein.	Alginates	4-12	albumin	Homo sapiens	144-157
31163388-6	2019	The thrombin-clotting time delay caused by CNWsAlg@SOx is ~ 170 times longer than that caused by sodium alginate.	Alginates	97-112	coagulation factor II	Rattus norvegicus	4-12
33448815-0	2019	Alginate Enhances Memory Properties of Antitumor CD8+ T Cells by Promoting Cellular Antioxidation.	Alginates	0-8	CD8a molecule	Homo sapiens	49-52
33448815-3	2019	By incubating sorted cytotoxic CD8+ T cells with alginate, we found that this material facilitated the antitumor cytotoxic activities of T cells.	Alginates	49-57	CD8a molecule	Homo sapiens	31-34
33448815-4	2019	Alginate incubation significantly promoted memory properties of CD8+ T cells and elevated the proportion of CD62L+CD44+ central memory T cell (TCM), a less differentiated T cell subset with high immune activity.	Alginates	0-8	CD8a molecule	Homo sapiens	64-67
33448815-4	2019	Alginate incubation significantly promoted memory properties of CD8+ T cells and elevated the proportion of CD62L+CD44+ central memory T cell (TCM), a less differentiated T cell subset with high immune activity.	Alginates	0-8	selectin L	Homo sapiens	108-113
33448815-4	2019	Alginate incubation significantly promoted memory properties of CD8+ T cells and elevated the proportion of CD62L+CD44+ central memory T cell (TCM), a less differentiated T cell subset with high immune activity.	Alginates	0-8	CD44 molecule (Indian blood group)	Homo sapiens	114-118
33448815-5	2019	Mechanistically, alginate reduced reactive oxide species in CD8+ T cells by increasing intracellular glutathione generation, which was critical for conferring T cells with memory properties.	Alginates	17-25	CD8a molecule	Homo sapiens	60-63
31128750-1	2019	Quantitatively paper-based senor is performed with simple distance-readout on mixed cellulose ester (MCE) filter paper based on acetylcholinesterase (AChE)-mediated alginate hydrogel.	Alginates	165-173	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-148
31128750-1	2019	Quantitatively paper-based senor is performed with simple distance-readout on mixed cellulose ester (MCE) filter paper based on acetylcholinesterase (AChE)-mediated alginate hydrogel.	Alginates	165-173	acetylcholinesterase (Cartwright blood group)	Homo sapiens	150-154
31128750-2	2019	The method is accomplished with the aid of the inhibition effect of target samples on the AChE enzyme-catalyzed hydrolysis of acetylcholine, which changes the pH value of the solution to release Ca2+ and trigger alginate hydrogelation.	Alginates	212-220	acetylcholinesterase (Cartwright blood group)	Homo sapiens	90-94
31497467-4	2019	l-Asparaginase activity of 17.68 U mL-1 was produced after 48 h using immobilized calcium-alginate (Ca-alginate) cells.	Alginates	82-98	L1 cell adhesion molecule	Mus musculus	35-39
31497467-4	2019	l-Asparaginase activity of 17.68 U mL-1 was produced after 48 h using immobilized calcium-alginate (Ca-alginate) cells.	Alginates	100-111	L1 cell adhesion molecule	Mus musculus	35-39
31234064-4	2019	In vitro experiments and cell adhesion/proliferation evaluation reveal that the chlorogenic acid-sodium alginate-peptide bridging system shows better bioaffinity than the control groups due to the BFP peptide on the surface of the hydrogel.	Alginates	97-112	ring finger protein 112	Homo sapiens	197-200
31203034-7	2019	Electromyography demonstrated a 71% increase in compound muscle action potential 9 weeks after transplantation following treatment with VEGF + IGF-1 alginate, compared to blank alginate in the rabbit model.	Alginates	149-157	insulin-like growth factor I	Oryctolagus cuniculus	143-148
31203034-7	2019	Electromyography demonstrated a 71% increase in compound muscle action potential 9 weeks after transplantation following treatment with VEGF + IGF-1 alginate, compared to blank alginate in the rabbit model.	Alginates	177-185	vascular endothelial growth factor A	Oryctolagus cuniculus	136-140
31102984-2	2019	Neurotrophic factor (NTF) producing cells encapsulated in an alginate-matrix, to shield them from the host immune system and to avoid migration, and applied as viscose solution or electrode coating could address this requirement.	Alginates	61-69	neurotrophin 3	Homo sapiens	0-19
31027772-7	2019	An increase of virulence factors amounts (leukotoxin and PROKKA_04561) were instead found at 30  C. HLF caused a significant reduction in biofilm biomass; indeed, at 15  C HLF repressed PleD, TycC and GbrS and induced the negative regulators of alginate biosynthesis; at both temperatures induced the cyclic-di-GMP-binding biofilm dispersal mediator (PROKKA_02061).	Alginates	245-253	HLF transcription factor, PAR bZIP family member	Bos taurus	100-103
31027772-7	2019	An increase of virulence factors amounts (leukotoxin and PROKKA_04561) were instead found at 30  C. HLF caused a significant reduction in biofilm biomass; indeed, at 15  C HLF repressed PleD, TycC and GbrS and induced the negative regulators of alginate biosynthesis; at both temperatures induced the cyclic-di-GMP-binding biofilm dispersal mediator (PROKKA_02061).	Alginates	245-253	HLF transcription factor, PAR bZIP family member	Bos taurus	172-175
31102984-2	2019	Neurotrophic factor (NTF) producing cells encapsulated in an alginate-matrix, to shield them from the host immune system and to avoid migration, and applied as viscose solution or electrode coating could address this requirement.	Alginates	61-69	neurotrophin 3	Homo sapiens	21-24
31102984-9	2019	Both application strategies are possible options for cell-induced drug-delivery to the inner ear, but an alginate-cell coating of CI-electrodes has a great potential to combine an endogenous NTF-source with a strong reduction of insertion forces.	Alginates	105-113	neurotrophin 3	Homo sapiens	191-194
31447858-8	2019	Moreover, in the 3D alginate spheres, the cytokine increased the expression of the immune checkpoint ligands PD-Ls and B7-H3 while virtually abrogating that of PVR, a ligand of DNAM-1 activating receptor, whose expression correlates with high susceptibility to NK-mediated killing.	Alginates	20-28	CD276 molecule	Homo sapiens	119-124
31433583-0	2019	Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model.	Alginates	37-45	prorelaxin	Sus scrofa	10-17
31433583-4	2019	The efficacy of sustained RLX expression to scar remodeling was assessed using an injectable alginate gel-matrix system.	Alginates	93-101	prorelaxin	Sus scrofa	26-29
31450763-6	2019	Digital microscopy images revealed that the as-formed alginate films at the flow rate of 100 microL min-1 and the N2 gas pressure of 0.8 bar have highly monodisperse microbubbles with a polydispersity index (PDI) of approximately 6.5%.	Alginates	54-62	CD59 molecule (CD59 blood group)	Homo sapiens	100-105
31411620-5	2019	A hydrogel, mainly composed of mucin in an alginate (Alg) network, is proposed to specifically model the chemical-physical properties of CF mucus.	Alginates	43-51	LOC100508689	Homo sapiens	31-36
31447858-8	2019	Moreover, in the 3D alginate spheres, the cytokine increased the expression of the immune checkpoint ligands PD-Ls and B7-H3 while virtually abrogating that of PVR, a ligand of DNAM-1 activating receptor, whose expression correlates with high susceptibility to NK-mediated killing.	Alginates	20-28	PVR cell adhesion molecule	Homo sapiens	160-163
31365542-1	2019	To induce osteogenicity in bone graft substitutes, plasmid-based expression of BMP-2 (pBMP-2) has been successfully applied in gene activated matrices based on alginate polymer constructs.	Alginates	160-168	bone morphogenetic protein 2	Rattus norvegicus	79-84
31401914-1	2019	This work describes viability and distribution of INS-1E beta cells in shell-crosslinked alginate capsules, focussing on cells located near the capsule surface.	Alginates	89-97	insulin 1	Rattus norvegicus	50-55
31365542-12	2019	However, alginate-based gene delivery of BMP-2 to host cells or seeded cells did not result in protein levels adequate for bone formation in this setting, calling for more reliable scaffold compatible transfection methods.	Alginates	9-17	bone morphogenetic protein 2	Rattus norvegicus	41-46
31311862-2	2019	Here, we demonstrate that biomaterial encapsulation into alginate using a microfluidic device could substantially increase in vivo MSC persistence after intravenous (i.v.)	Alginates	57-65	musculin	Homo sapiens	131-134
31447554-2	2019	Methods: Inspired by the excellent adhesion properties of mussel protein, we prepared novel catechol-grafted chitosan alginate/barium sulfate microcapsules (Cat-CA/BS MCs) with mucoadhesive properties and computed tomography (CT) imaging function for gastric drug delivery.	Alginates	118-126	catalase	Homo sapiens	157-160
31264828-5	2019	We describe a two-step cross-linking strategy for the fabrication of a P(AAm-AMPS)/alginate double-network hydrogel in the presence of air, which enables greater independent control over surface chemistry and functionality than homogeneously processed conventional double-network hydrogels.	Alginates	83-91	adenylosuccinate lyase	Homo sapiens	77-81
30980873-0	2019	Alginate/chitosan multilayer films coated on IL-4-loaded TiO2 nanotubes for modulation of macrophage phenotype.	Alginates	0-8	interleukin 4	Homo sapiens	45-49
30980873-5	2019	Subsequently, sodium alginate (ALG) and chitosan (CS) were alternately assembled onto IL-4-loaded TNTs and cross-linked with genipin/calcium chloride, finally forming cross-linked PEM films.	Alginates	14-29	interleukin 4	Homo sapiens	86-90
30980873-5	2019	Subsequently, sodium alginate (ALG) and chitosan (CS) were alternately assembled onto IL-4-loaded TNTs and cross-linked with genipin/calcium chloride, finally forming cross-linked PEM films.	Alginates	31-34	interleukin 4	Homo sapiens	86-90
31329175-0	2019	Fabrication of Amyloid-beta-Secreting Alginate Microbeads for Use in Modelling Alzheimer"s Disease.	Alginates	38-46	amyloid beta precursor protein	Homo sapiens	15-27
30748094-0	2019	Alginate-microencapsulation of human stem cell-derived beta cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression.	Alginates	0-8	C-X-C motif chemokine ligand 12	Homo sapiens	71-77
30748094-5	2019	Here we used a novel approach to evade the pericapsular fibrotic response to alginate-microencapsulated SC-beta cells; an immunomodulatory chemokine, CXCL12, was incorporated into clinical grade sodium alginate to microencapsulate SC-beta cells.	Alginates	77-85	C-X-C motif chemokine ligand 12	Homo sapiens	150-156
30748094-5	2019	Here we used a novel approach to evade the pericapsular fibrotic response to alginate-microencapsulated SC-beta cells; an immunomodulatory chemokine, CXCL12, was incorporated into clinical grade sodium alginate to microencapsulate SC-beta cells.	Alginates	195-210	C-X-C motif chemokine ligand 12	Homo sapiens	150-156
31030059-6	2019	Alginate membranes containing either glucose oxidase (GOx) or lactate oxidase (LOx) were selectively electrodeposited on the surface of each working electrode in around 4 min, completing sample measurement in less than 1 min.	Alginates	0-8	hydroxyacid oxidase 1	Homo sapiens	37-52
31030059-6	2019	Alginate membranes containing either glucose oxidase (GOx) or lactate oxidase (LOx) were selectively electrodeposited on the surface of each working electrode in around 4 min, completing sample measurement in less than 1 min.	Alginates	0-8	hydroxyacid oxidase 1	Homo sapiens	54-57
31030059-6	2019	Alginate membranes containing either glucose oxidase (GOx) or lactate oxidase (LOx) were selectively electrodeposited on the surface of each working electrode in around 4 min, completing sample measurement in less than 1 min.	Alginates	0-8	lysyl oxidase	Homo sapiens	62-77
31030059-6	2019	Alginate membranes containing either glucose oxidase (GOx) or lactate oxidase (LOx) were selectively electrodeposited on the surface of each working electrode in around 4 min, completing sample measurement in less than 1 min.	Alginates	0-8	lysyl oxidase	Homo sapiens	79-82
31441788-9	2019	This study showed that hydrogel enriched with alginate, fatty acids, and vitamins A and E provided promising results for the treatment of pressure injuries by reducing the lesion area, the general PUSH score, and the amount of MMP9 in the wounds" microenvironment.	Alginates	46-54	matrix metallopeptidase 9	Homo sapiens	227-231
30936010-0	2019	Alginate/chitosan multilayer films coated on IL-4-loaded TiO2 nanotubes for modulation of macrophage phenotype.	Alginates	0-8	interleukin 4	Homo sapiens	45-49
30936010-5	2019	Subsequently, sodium alginate (ALG) and chitosan (CS) were alternately assembled onto IL-4-loaded TNTs and cross-linked with genipin/calcium chloride, finally forming cross-linked PEM films.	Alginates	14-29	interleukin 4	Homo sapiens	86-90
30936010-5	2019	Subsequently, sodium alginate (ALG) and chitosan (CS) were alternately assembled onto IL-4-loaded TNTs and cross-linked with genipin/calcium chloride, finally forming cross-linked PEM films.	Alginates	31-34	interleukin 4	Homo sapiens	86-90
30851342-0	2019	Lactoferrin-Loaded Alginate Microparticles to Target Clostridioides difficile Infection.	Alginates	19-27	lactotransferrin	Bos taurus	0-11
30851342-10	2019	The future potential of lactoferrin-loaded alginate microparticles against C difficile deserves further study.	Alginates	43-51	lactotransferrin	Bos taurus	24-35
31209685-4	2019	Escherichia coli bacteriophage ZSEC5 is rendered inactive at pH 2.0 but encapsulation in chitosan-alginate bead with a honey and gelatin matrix limited titer reductions to 1 log10 PFU mL-1.	Alginates	98-106	L1 cell adhesion molecule	Mus musculus	184-188
31141337-0	2019	Sustainable Dual Release of Antibiotic and Growth Factor from pH-Responsive Uniform Alginate Composite Microparticles to Enhance Wound Healing.	Alginates	84-92	myotrophin	Rattus norvegicus	43-56
31334345-0	2019	Erratum: Preliminary Studies of the Impact of CXCL12 on the Foreign Body Reaction to Pancreatic Islets Microencapsulated in Alginate in Nonhuman Primates: Erratum.	Alginates	124-132	C-X-C motif chemokine ligand 12	Homo sapiens	46-52
30926490-0	2019	Facile fabrication of core-shell/bead-like ethylenediamine-functionalized Al-pillared montmorillonite/calcium alginate for As(V) ion adsorption.	Alginates	102-118	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	123-128
30902713-1	2019	Chitosan/alginate nanoparticles (CANPs) were formulated to encapsulate curcumin diethyl diglutarate (CDG) for oral delivery.	Alginates	9-17	calpain small subunit 1	Homo sapiens	33-38
30902713-5	2019	The optimal CDG-CANPs could be prepared by chitosan/alginate mass ratio of 0.065:1, 1% (w/v) Pluronic F127 and 4.5 mg/mL of CDG.	Alginates	52-60	calpain small subunit 1	Homo sapiens	12-21
30901634-2	2019	Here, we evaluated whether macroporous alginate scaffolds with affinity-bound bone morphogenetic protein-4 (BMP-4) could mimic the ovary microenvironment and support the culture and growth of primordial follicles seeded with supporting ovarian cells.	Alginates	39-47	bone morphogenetic protein 4	Homo sapiens	78-106
31050412-2	2019	The CNF networks were formed by vacuum filtration of dilute dispersions (0.2 wt %) of 90% CNFs and 10% alginate.	Alginates	103-111	NPHS1 adhesion molecule, nephrin	Homo sapiens	4-7
30901634-2	2019	Here, we evaluated whether macroporous alginate scaffolds with affinity-bound bone morphogenetic protein-4 (BMP-4) could mimic the ovary microenvironment and support the culture and growth of primordial follicles seeded with supporting ovarian cells.	Alginates	39-47	bone morphogenetic protein 4	Homo sapiens	108-113
30317587-5	2019	The results of this study showed that MSCs differentiated in alginate microfibers (fabricated by microfluidic device) express more Pdx-1 mRNA (1.938-fold, p-value: 0.0425) and Insulin mRNA (2.841-fold, p-value: 0.0001) compared with those cultured on TCPS.	Alginates	61-69	pancreatic and duodenal homeobox 1	Rattus norvegicus	131-136
31218857-1	2019	OBJECTIVE: This study aimed to optimize the preparation of carboxymethyl chitosan/sodium alginate (CMCS/OSA) compound hydrogels.	Alginates	82-97	G protein signaling modulator 2	Homo sapiens	99-103
30240714-0	2019	Chemical modification of alginate with cysteine and its application for the removal of Pb(II) from aqueous solutions.	Alginates	25-33	submaxillary gland androgen regulated protein 3B	Homo sapiens	87-93
30240714-1	2019	It has been synthesized, characterized and tested a new biomaterial AlgS (sodium alginate functionalized with cysteine) to remove Pb(II) in aqueous media.	Alginates	74-89	submaxillary gland androgen regulated protein 3B	Homo sapiens	130-136
30240714-3	2019	Techniques, such as TGA/DSC, SEM/EDS, BET, FTIR, UV-Vis, XRD and 13C solid state-NMR have been used to study the chemical-modification of alginate at oxidation and aminofication stages.	Alginates	138-146	T-box transcription factor 1	Homo sapiens	20-23
30240714-3	2019	Techniques, such as TGA/DSC, SEM/EDS, BET, FTIR, UV-Vis, XRD and 13C solid state-NMR have been used to study the chemical-modification of alginate at oxidation and aminofication stages.	Alginates	138-146	desmocollin 3	Homo sapiens	24-27
30240714-3	2019	Techniques, such as TGA/DSC, SEM/EDS, BET, FTIR, UV-Vis, XRD and 13C solid state-NMR have been used to study the chemical-modification of alginate at oxidation and aminofication stages.	Alginates	138-146	delta/notch like EGF repeat containing	Homo sapiens	38-41
30378751-3	2019	We developed a microfluidic encapsulation system that generates synthetic poly(ethylene glycol)-based microgels with smaller diameters (310 +- 14 mum) that improve encapsulated islet insulin responsiveness over alginate capsules and allow transplant within vascularized tissue spaces, thereby reducing islet mass requirements and graft volumes.	Alginates	211-219	insulin	Homo sapiens	183-190
30797114-3	2019	Here, an injectable composite alginate-collagen (CAC) ECT gel with a Tet-on inducible pro-caspase 8 mechanism that acted as an orally-inducible biosafety switch was developed for safer drug delivery.	Alginates	30-38	caspase 8	Rattus norvegicus	90-99
30849562-0	2019	Injectable basic fibroblast growth factor-loaded alginate/hyaluronic acid hydrogel for rejuvenation of geriatric larynx.	Alginates	49-57	fibroblast growth factor 2	Rattus norvegicus	11-41
31149016-0	2019	A Bioactive Cartilage Graft of IGF1-Transduced Adipose Mesenchymal Stem Cells Embedded in an Alginate/Bovine Cartilage Matrix Tridimensional Scaffold.	Alginates	93-101	insulin like growth factor 1	Bos taurus	31-35
31149016-4	2019	This study reports the development of an implant constructed with IGF1-transduced adipose-derived mesenchymal stem cells (immunophenotypes: CD105+, CD90+, CD73+, CD14-, and CD34-) embedded in a scaffold composed of a mix of alginate/milled bovine decellularized knee material which was cultivated in vitro for 28 days (3CI).	Alginates	224-232	insulin like growth factor 1	Bos taurus	66-70
30849562-4	2019	Thus, we fabricated an injectable basic fibroblast growth factor (bFGF)-loaded alginate (ALG)/hyaluronic acid (HA) hydrogel for inducing rejuvenation of geriatric laryngeal muscles.	Alginates	89-92	fibroblast growth factor 2	Rattus norvegicus	66-70
30849562-4	2019	Thus, we fabricated an injectable basic fibroblast growth factor (bFGF)-loaded alginate (ALG)/hyaluronic acid (HA) hydrogel for inducing rejuvenation of geriatric laryngeal muscles.	Alginates	79-87	fibroblast growth factor 2	Rattus norvegicus	34-64
30849562-4	2019	Thus, we fabricated an injectable basic fibroblast growth factor (bFGF)-loaded alginate (ALG)/hyaluronic acid (HA) hydrogel for inducing rejuvenation of geriatric laryngeal muscles.	Alginates	79-87	fibroblast growth factor 2	Rattus norvegicus	66-70
30849562-4	2019	Thus, we fabricated an injectable basic fibroblast growth factor (bFGF)-loaded alginate (ALG)/hyaluronic acid (HA) hydrogel for inducing rejuvenation of geriatric laryngeal muscles.	Alginates	89-92	fibroblast growth factor 2	Rattus norvegicus	34-64
33405564-5	2019	More importantly, a leptin sustained release system was developed using a hydrogel with calcium alginate microspheres and was transplanted into cartilage defects in rabbit femurs to analyze the effect of leptin on promoting cartilage restoration.	Alginates	88-104	leptin	Homo sapiens	20-26
31165082-1	2019	Background: We previously demonstrated that the incorporation of the chemokine CXCL12 into alginate microbeads supported long-term survival of microencapsulated auto-, allo-, and xenogeneic islets in murine models of diabetes without systemic immune suppression.	Alginates	91-99	chemokine (C-X-C motif) ligand 12	Mus musculus	79-85
31165082-5	2019	Results: CXCL12-containing alginate microbeads were associated with a markedly reduced FBR to microbeads.	Alginates	27-35	chemokine (C-X-C motif) ligand 12	Mus musculus	9-15
31165082-10	2019	Conclusions: Inclusion of CXCL12 in alginate microbeads minimized localized FBR.	Alginates	36-44	chemokine (C-X-C motif) ligand 12	Mus musculus	26-32
30970577-0	2019	Synergistic Effects of Photo-Irradiation and Curcumin-Chitosan/Alginate Nanoparticles on Tumor Necrosis Factor-Alpha-Induced Psoriasis-Like Proliferation of Keratinocytes.	Alginates	63-71	tumor necrosis factor	Homo sapiens	89-116
30970577-3	2019	In this study, we demonstrate that a combination of curcumin-loaded chitosan/alginate nanoparticles (Cur-CS/Alg NPs) and blue light emitting diodes (LED) light irradiation effectively suppressed the hyperproliferation of tumor necrosis factor-alpha (TNF-alpha)-induced cultured human kerlatinocyte (HaCaT) cells.	Alginates	77-85	tumor necrosis factor	Homo sapiens	221-248
30970577-3	2019	In this study, we demonstrate that a combination of curcumin-loaded chitosan/alginate nanoparticles (Cur-CS/Alg NPs) and blue light emitting diodes (LED) light irradiation effectively suppressed the hyperproliferation of tumor necrosis factor-alpha (TNF-alpha)-induced cultured human kerlatinocyte (HaCaT) cells.	Alginates	77-85	tumor necrosis factor	Homo sapiens	250-259
30658141-6	2019	Bull Serum Albumin (BSA) was encapsulated into alginate gel microspheres and subsequently incorporated into OAlg/N-Chi hydrogels to produce a composite scaffold.	Alginates	47-55	albumin	Homo sapiens	5-18
30779979-2	2019	The present study sought to fabricate alginate/chitosan microcapsules containing IL-1Ra (Alg/Chi/IL-1Ra MC) via a single-step electrospraying method.	Alginates	38-46	interleukin 1 receptor antagonist	Mus musculus	81-87
30960606-0	2019	Adsorption and Electrochemical Detection of Bovine Serum Albumin Imprinted Calcium Alginate Hydrogel Membrane.	Alginates	75-91	albumin	Homo sapiens	51-64
30960606-1	2019	In this paper, bovine serum albumin (BSA)-imprinted calcium alginate (CaAlg) hydrogel membrane was prepared using BSA as a template, sodium alginate (NaAlg) as a functional monomer, and CaCl2 as a cross-linker.	Alginates	52-68	albumin	Homo sapiens	22-35
30960606-1	2019	In this paper, bovine serum albumin (BSA)-imprinted calcium alginate (CaAlg) hydrogel membrane was prepared using BSA as a template, sodium alginate (NaAlg) as a functional monomer, and CaCl2 as a cross-linker.	Alginates	70-75	albumin	Homo sapiens	22-35
30960606-1	2019	In this paper, bovine serum albumin (BSA)-imprinted calcium alginate (CaAlg) hydrogel membrane was prepared using BSA as a template, sodium alginate (NaAlg) as a functional monomer, and CaCl2 as a cross-linker.	Alginates	133-148	albumin	Homo sapiens	22-35
30779979-0	2019	Alginate/chitosan microcapsules for in-situ delivery of the protein, interleukin-1 receptor antagonist (IL-1Ra), for the treatment of dextran sulfate sodium (DSS)-induced colitis in a mouse model.	Alginates	0-8	interleukin 1 receptor antagonist	Mus musculus	69-102
30779979-0	2019	Alginate/chitosan microcapsules for in-situ delivery of the protein, interleukin-1 receptor antagonist (IL-1Ra), for the treatment of dextran sulfate sodium (DSS)-induced colitis in a mouse model.	Alginates	0-8	interleukin 1 receptor antagonist	Mus musculus	104-110
30802890-7	2019	Von Kossa staining showed mineralization nodules and MSCs morphology changed from spindle to cuboid shape after 21 d. Finally, BMP-2 and ALP mRNA were significantly upregulated on cells grown into the BT NP/alginate 3D scaffold.	Alginates	207-215	bone morphogenetic protein 2	Homo sapiens	127-132
30802890-7	2019	Von Kossa staining showed mineralization nodules and MSCs morphology changed from spindle to cuboid shape after 21 d. Finally, BMP-2 and ALP mRNA were significantly upregulated on cells grown into the BT NP/alginate 3D scaffold.	Alginates	207-215	ATHS	Homo sapiens	137-140
30825603-3	2019	By releasing DMOG from mesenchymal stem cell (MSC) laden alginate hydrogels, it is possible to stabilize HIF-1alpha and enhance its nuclear localization.	Alginates	57-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-115
30779979-2	2019	The present study sought to fabricate alginate/chitosan microcapsules containing IL-1Ra (Alg/Chi/IL-1Ra MC) via a single-step electrospraying method.	Alginates	38-46	interleukin 1 receptor antagonist	Mus musculus	97-103
30593804-0	2019	Pectin hydrolysis in cashew apple juice by Aspergillus aculeatus URM4953 polygalacturonase covalently-immobilized on calcium alginate beads: A kinetic and thermodynamic study.	Alginates	117-133	polygalacturonase	Malus domestica	73-90
30593804-1	2019	The kinetics and thermodynamics of pectin hydrolysis in cashew apple juice by polygalacturonase (PG) from Aspergillus aculeatus URM4953 covalently-immobilized on calcium alginate beads were investigated.	Alginates	162-178	polygalacturonase	Malus domestica	78-95
30593804-1	2019	The kinetics and thermodynamics of pectin hydrolysis in cashew apple juice by polygalacturonase (PG) from Aspergillus aculeatus URM4953 covalently-immobilized on calcium alginate beads were investigated.	Alginates	162-178	polygalacturonase	Malus domestica	97-99
30447081-4	2019	Compared with the control, polyphenol oxidase (PPO), peroxidase (POD) and phenylalanine ammonia-lyase (PAL) activities of PLA-SA blend coating treated minimally processed lily bulbs reduced by about 31%, 21% and 29% on the 15th day, respectively.	Alginates	126-128	protoporphyrinogen oxidase	Homo sapiens	27-45
30447081-4	2019	Compared with the control, polyphenol oxidase (PPO), peroxidase (POD) and phenylalanine ammonia-lyase (PAL) activities of PLA-SA blend coating treated minimally processed lily bulbs reduced by about 31%, 21% and 29% on the 15th day, respectively.	Alginates	126-128	protoporphyrinogen oxidase	Homo sapiens	47-50
30447081-4	2019	Compared with the control, polyphenol oxidase (PPO), peroxidase (POD) and phenylalanine ammonia-lyase (PAL) activities of PLA-SA blend coating treated minimally processed lily bulbs reduced by about 31%, 21% and 29% on the 15th day, respectively.	Alginates	126-128	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	74-101
30447081-4	2019	Compared with the control, polyphenol oxidase (PPO), peroxidase (POD) and phenylalanine ammonia-lyase (PAL) activities of PLA-SA blend coating treated minimally processed lily bulbs reduced by about 31%, 21% and 29% on the 15th day, respectively.	Alginates	126-128	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	103-106
30562520-0	2019	Highly efficient adsorption of Pb(II) from aqueous solution using amino-functionalized SBA-15/calcium alginate microspheres as adsorbent.	Alginates	94-110	submaxillary gland androgen regulated protein 3B	Homo sapiens	31-37
30848259-6	2019	SPI + ALG-6 and SPI + ALG-7 exhibited a significant reduction in the peak glucose concentration compared to SPI without alginate (P &lt; 0.05).	Alginates	120-128	chromogranin A	Homo sapiens	0-3
30848259-6	2019	SPI + ALG-6 and SPI + ALG-7 exhibited a significant reduction in the peak glucose concentration compared to SPI without alginate (P &lt; 0.05).	Alginates	120-128	chromogranin A	Homo sapiens	16-19
30848259-6	2019	SPI + ALG-6 and SPI + ALG-7 exhibited a significant reduction in the peak glucose concentration compared to SPI without alginate (P &lt; 0.05).	Alginates	120-128	chromogranin A	Homo sapiens	16-19
33405624-2	2019	Herein, we present a plasmid DNA (pDNA; bFGF gene encoding) complex-loaded alginate (ALG)/hyaluronic acid (HA) mixture hydrogel dispersed with polycaprolactone (PCL) microspheres that can enhance simultaneous regeneration of VF muscle and lamina propria, as well as have a bulking effect on atrophied VF.	Alginates	75-83	fibroblast growth factor 2	Homo sapiens	40-44
33405624-2	2019	Herein, we present a plasmid DNA (pDNA; bFGF gene encoding) complex-loaded alginate (ALG)/hyaluronic acid (HA) mixture hydrogel dispersed with polycaprolactone (PCL) microspheres that can enhance simultaneous regeneration of VF muscle and lamina propria, as well as have a bulking effect on atrophied VF.	Alginates	85-88	fibroblast growth factor 2	Homo sapiens	40-44
30714345-2	2019	Herein, a promising strategy for effective delivery of phosphorothioated antisense oligodeoxyribonucleotide of TNF-alpha (PS-ATNF-alpha), targeting the intestinal inflammation based on the interaction of the single chain of triple helical beta-glucan (s-LNT) with poly-deoxyadenylic acid [poly(dA)], and the colon-specific degradation of chitosan-alginate (CA) hydrogel, is reported.	Alginates	347-355	tumor necrosis factor	Homo sapiens	111-120
30553381-0	2019	Effects of pH, extrusion tip size and storage protocol on the structural properties of Ca(II)-alginate beads.	Alginates	94-102	carbonic anhydrase 2	Homo sapiens	87-92
30496862-5	2019	The pseudo-second-order kinetic and Freundlich isotherm models combining with the correlative analysis implied that the tetracycline adsorption onto the Cu-immobilized alginate adsorbent was administrated by the n-pi electron-donor-acceptor interaction (n-pi EDA interaction), hydrogen bond and the cation bonding bridge.	Alginates	168-176	ectodysplasin A	Homo sapiens	259-262
30823628-0	2019	Development of Novel EE/Alginate Polyelectrolyte Complex Nanoparticles for Lysozyme Delivery: Physicochemical Properties and In Vitro Safety.	Alginates	24-32	lysozyme	Homo sapiens	75-83
30823628-5	2019	Our results showed that electrostatic interactions between the EE-alginate and lysozyme led to the formation of EE/alginate Lys pNPs with reproducible size, high stability due to their controllable zeta potential, a high association efficiency, and an in vitro sustained Lys release.	Alginates	66-74	lysozyme	Homo sapiens	79-87
30823628-5	2019	Our results showed that electrostatic interactions between the EE-alginate and lysozyme led to the formation of EE/alginate Lys pNPs with reproducible size, high stability due to their controllable zeta potential, a high association efficiency, and an in vitro sustained Lys release.	Alginates	115-123	lysozyme	Homo sapiens	79-87
30624837-0	2019	Uptake of Pb(II) onto nanochitosan/sodium alginate hybrid beads: Mechanism and kinetics study.	Alginates	35-50	submaxillary gland androgen regulated protein 3B	Homo sapiens	10-16
30624837-1	2019	Nanochitosan/sodium alginate (NCS/SA) beads were prepared using nanochitosan and alginate as a high-performance absorbent for Pb(II) removal from aqueous solution.	Alginates	13-28	submaxillary gland androgen regulated protein 3B	Homo sapiens	126-132
30624837-1	2019	Nanochitosan/sodium alginate (NCS/SA) beads were prepared using nanochitosan and alginate as a high-performance absorbent for Pb(II) removal from aqueous solution.	Alginates	20-28	submaxillary gland androgen regulated protein 3B	Homo sapiens	126-132
30597265-0	2019	Hyaluronic acid enhances cell survival of encapsulated insulin-producing cells in alginate-based microcapsules.	Alginates	82-90	insulin	Homo sapiens	55-62
30597265-6	2019	Therefore, we can conclude that the inclusion of HA within alginate microcapsules is beneficial for encapsulated insulin-producing cells, representing a step forward in the clinical translation of microcapsules technology for the treatment of T1DM.	Alginates	59-67	insulin	Homo sapiens	113-120
30881954-6	2019	In vivo, FST was loaded in an in situ gelling formulation made by alginate and recombinant collagen-based peptide microspheres and implanted in a rat calvarial defect model.	Alginates	66-74	follistatin	Rattus norvegicus	9-12
30906768-9	2019	Differentiated C2C12 cells encapsulated in alginate had a significant increase in MuRF1 only following simulated microgravity culture and were morphologically dissimilar to normal cultured muscle tissue.	Alginates	43-51	tripartite motif-containing 63	Mus musculus	82-87
30960218-9	2019	Polymers containing 1% sodium alginate were efficient in Cr6+ ion removal, while those containing 2% in Cu2+ ion removal.	Alginates	23-38	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	57-60
30446115-3	2019	The TGA and tensile studies confirmed that incorporation of TS-SA into the polyurethane backbone provide the superior thermal and mechanical properties compared to SA.	Alginates	63-65	T-box transcription factor 1	Homo sapiens	4-7
30404027-1	2019	In the present work, we aimed to explore the molecular binding between alginate and beta-galactosidase, as well as the effect of this interaction on the activity retention, thermal stability, and kinetic properties of the enzyme.	Alginates	71-79	galactosidase beta 1	Homo sapiens	84-102
30404027-4	2019	The binding between beta-galactosidase and alginate was an equilibrium between enthalpic and entropic contributions, which promoted changes in the structure of the enzyme.	Alginates	43-51	galactosidase beta 1	Homo sapiens	20-38
30485631-2	2019	In this study, we used a blend of alginate sulfate (ALG-S) and polyvinyl alcohol (PVA) to fabricate electrospun scaffolds capable of delivering a heparin-like growth factor, transforming growth factor-beta1 (TGF-beta1).	Alginates	52-57	transforming growth factor beta 1	Homo sapiens	174-206
30485631-2	2019	In this study, we used a blend of alginate sulfate (ALG-S) and polyvinyl alcohol (PVA) to fabricate electrospun scaffolds capable of delivering a heparin-like growth factor, transforming growth factor-beta1 (TGF-beta1).	Alginates	52-57	transforming growth factor beta 1	Homo sapiens	208-217
30485631-7	2019	The results showed that the binding and entrapment of TGF-beta1 to the nanofibrous scaffolds are improved by the addition of sulfate group to alginate.	Alginates	142-150	transforming growth factor beta 1	Homo sapiens	54-63
30960324-0	2019	Sorption and Desorption Studies of Pb(II) and Ni(II) from Aqueous Solutions by a New Composite Based on Alginate and Magadiite Materials.	Alginates	104-112	submaxillary gland androgen regulated protein 3B	Homo sapiens	35-52
30628334-2	2019	The characteristics of the Fe0/alginate microsphere was characterized by FT-IR, SEM, BET, and XPS.	Alginates	31-39	delta/notch like EGF repeat containing	Homo sapiens	85-88
30628334-3	2019	The SEM and BET analyses showed that the Fe0/alginate microsphere had a multilevel porous structure and could adsorb ARB.	Alginates	45-53	delta/notch like EGF repeat containing	Homo sapiens	12-15
30601665-5	2019	Moreover, the addition of hyaluronic acid (HA) in alginate microcapsules enhanced, even more, the insulin release from the final IPCs, independent of the MSC source.	Alginates	50-58	insulin	Homo sapiens	98-105
30601665-6	2019	We can conclude that MSCs can be differentiated into IPCs within alginate microcapsules, enhancing insulin release when HA is present in the 3D alginate matrixes.	Alginates	144-152	insulin	Homo sapiens	99-106
29569344-0	2019	Application of alginate microbeads as a carrier of bone morphogenetic protein-2 for bone regeneration.	Alginates	15-23	bone morphogenetic protein 2	Rattus norvegicus	51-79
29569344-5	2019	In the present study, we used alginate microbeads as a delivery vehicle for BMP-2.	Alginates	30-38	bone morphogenetic protein 2	Rattus norvegicus	76-81
29569344-7	2019	The objective of this study was to evaluate that the osteoinductive properties of BMP-2 are effective in alginate microbeads as a carrier.	Alginates	105-113	bone morphogenetic protein 2	Rattus norvegicus	82-87
29569344-8	2019	In this study, the release kinetics of BMP-2 in alginate microbeads was evaluated using an enzyme-linked immunosorbent assay.	Alginates	48-56	bone morphogenetic protein 2	Rattus norvegicus	39-44
29569344-9	2019	BMP-2 released from alginate microbeads induced high alkaline phosphatase activity in canine adipose tissue-derived mesenchymal stem cells.	Alginates	20-28	bone morphogenetic protein 2	Canis lupus familiaris	0-5
29569344-10	2019	Injection of alginate microbeads with BMP-2 into mouse subcutaneous tissue, as well as surgical implantation into the 5-mm circular calvarial defects in rats, was conducted and the results showed extensive new bone formation.	Alginates	13-21	bone morphogenetic protein 2	Mus musculus	38-43
29569344-11	2019	In conclusion, alginate microbeads can be utilized as an effective BMP-2 delivery vehicle for use in orthopedic surgery and as an injectable vehicle for a minimally invasive therapy.	Alginates	15-23	bone morphogenetic protein 2	Rattus norvegicus	67-72
30594363-1	2019	Lactobacillus helveticus LB 10 proteinases immobilized with sodium alginate were used to hydrolyze whey protein to produce angiotensin-I-converting enzyme (ACE)-inhibitory peptides.	Alginates	60-75	angiotensin I converting enzyme	Homo sapiens	123-154
30594363-1	2019	Lactobacillus helveticus LB 10 proteinases immobilized with sodium alginate were used to hydrolyze whey protein to produce angiotensin-I-converting enzyme (ACE)-inhibitory peptides.	Alginates	60-75	angiotensin I converting enzyme	Homo sapiens	156-159
30606221-11	2019	29-mer/alginate gel treatment caused extensive expansion of CD146+ TSPC in their niche on postoperative day 2, followed by infiltration of CD146+/BrdU- TSPC into the injured tendon on day 7.	Alginates	7-15	melanoma cell adhesion molecule	Rattus norvegicus	60-65
30678140-1	2019	Alginates, being linear anionic co-polymers of 1,4-linked residues beta-d-ManA (M) and alpha-l-GulA (G), are widely applied as hydrogel biomaterials due to their favourable in vivo biocompatibility and convenient ionic crosslinking.	Alginates	0-9	mannosidase alpha class 2C member 1	Homo sapiens	74-78
30606221-11	2019	29-mer/alginate gel treatment caused extensive expansion of CD146+ TSPC in their niche on postoperative day 2, followed by infiltration of CD146+/BrdU- TSPC into the injured tendon on day 7.	Alginates	7-15	melanoma cell adhesion molecule	Rattus norvegicus	139-144
31490744-3	2019	In these bioceramic-biopolymeric systems, HAp crystallites have been well inviolate with the alginate molecules.	Alginates	93-101	reticulon 3	Homo sapiens	42-45
31490744-4	2019	The objective of this review article is to present a comprehensive discussion of different recently researched drug releasing potential by HAp-alginate based matrices.	Alginates	143-151	reticulon 3	Homo sapiens	139-142
31490744-5	2019	METHODS: During past few years, HAp particles (both synthesized and naturally derived) have been reinforced within different alginate based systems to load a variety of drug candidates.	Alginates	125-133	reticulon 3	Homo sapiens	32-35
31490744-6	2019	Most of the reported drug releasing HAp-alginate based matrices was prepared by the methodology of ionic-gelation of sodium alginate followed by air-drying/spray drying process.	Alginates	117-132	reticulon 3	Homo sapiens	36-39
31490744-7	2019	RESULTS: HAp-alginate systems have already been proved as useful for loading a variety of drugs and also resulting sustained drug delivery with minimizing the drawbacks of pure alginate matrices (such as burst drug releasing and low mechanical property in the alkaline pH).	Alginates	13-21	reticulon 3	Homo sapiens	9-12
31490744-7	2019	RESULTS: HAp-alginate systems have already been proved as useful for loading a variety of drugs and also resulting sustained drug delivery with minimizing the drawbacks of pure alginate matrices (such as burst drug releasing and low mechanical property in the alkaline pH).	Alginates	177-185	reticulon 3	Homo sapiens	9-12
31490744-8	2019	CONCLUSION: HAp-alginate composites loaded with different kinds of drugs have already been reported to exhibit sustained releasing of loaded drugs over a longer period.	Alginates	16-24	reticulon 3	Homo sapiens	12-15
30142365-0	2018	Chemical modification of sodium alginate with thiosemicarbazide for the removal of Pb(II) and Cd(II) from aqueous solutions.	Alginates	25-40	submaxillary gland androgen regulated protein 3B	Homo sapiens	83-100
30958080-2	2019	Here, an innovative pH-sensitive PEC for insulin oral administration was developed, which was formed by self-assembly of two oppositely charged nanoparticles (chitosan-coated nanoparticles and alginate-coated nanoparticles) through electrostatic interaction via optimised double emulsion method.	Alginates	193-201	insulin	Homo sapiens	41-48
30958080-3	2019	The encapsulation efficiency of insulin-loaded alginate-coated and chitosan-coated nanoparticles were 81.5 +- 7.4% and 55.2 +- 7.0%, respectively, and the particle size of these nanoparticles were in 200-300 nm range.	Alginates	47-55	insulin	Homo sapiens	32-39
30196003-0	2018	Alginate-modified biochar derived from Ca(II)-impregnated biomass: Excellent anti-interference ability for Pb(II) removal.	Alginates	0-8	submaxillary gland androgen regulated protein 3B	Homo sapiens	107-113
30172819-1	2018	In the present study, we synthesized an effective Pb(II) adsorbent from magnetic carboxyl-functionalized attapulgite (McAPT) and sodium alginate (Alg) by simple mechanical agitation at room temperature.	Alginates	129-144	submaxillary gland androgen regulated protein 3B	Homo sapiens	50-56
30172819-1	2018	In the present study, we synthesized an effective Pb(II) adsorbent from magnetic carboxyl-functionalized attapulgite (McAPT) and sodium alginate (Alg) by simple mechanical agitation at room temperature.	Alginates	146-149	submaxillary gland androgen regulated protein 3B	Homo sapiens	50-56
30958080-0	2019	Self-assembly pH-sensitive chitosan/alginate coated polyelectrolyte complexes for oral delivery of insulin.	Alginates	36-44	insulin	Homo sapiens	99-106
30414695-0	2019	Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele.	Alginates	0-8	fibroblast growth factor 2	Rattus norvegicus	36-66
31030762-6	2019	PSS is produced by modifying partially hydrolyzed alginate, one of the most abundant marine polysaccharides isolated from brown algae, by epoxypropane esterification and by chemical sulfation.	Alginates	50-58	PSS	Homo sapiens	0-3
30590908-4	2018	Bone morphogenic proteins (BMP-2) and indispensable ECM proteins both directed differentiation inside alginate beads.	Alginates	102-110	bone morphogenetic protein 2	Homo sapiens	27-32
30590908-6	2018	Augmentation of alginate is necessary, and we showed that a few rationally selected small proteins from the basement membrane (BM) compartment of the ECM were sufficient to upregulate cell expression of Runx-2 and osteocalcin for osteoid formation, resulting in Alizarin red-positive mineral nodules.	Alginates	16-24	RUNX family transcription factor 2	Homo sapiens	203-209
30590908-6	2018	Augmentation of alginate is necessary, and we showed that a few rationally selected small proteins from the basement membrane (BM) compartment of the ECM were sufficient to upregulate cell expression of Runx-2 and osteocalcin for osteoid formation, resulting in Alizarin red-positive mineral nodules.	Alginates	16-24	bone gamma-carboxyglutamate protein	Homo sapiens	214-225
30170057-5	2018	The present review highlights the recent advances on the development of nanoparticles prepared from polysaccharides, including chitosan, alginate, dextran and glucan, for oral delivery of insulin, overcoming multiple barriers in gastrointestinal tract.	Alginates	137-145	insulin	Homo sapiens	188-195
30142365-1	2018	A new material (AlgOx-TSC), based on alginate (Alg) chemically modified with thiosemicarbazide (TSC), has been synthesized and tested as an effective biomaterial to remove Pb(II) and Cd(II) ions in aqueous solutions.	Alginates	37-45	submaxillary gland androgen regulated protein 3B	Homo sapiens	172-189
30142365-1	2018	A new material (AlgOx-TSC), based on alginate (Alg) chemically modified with thiosemicarbazide (TSC), has been synthesized and tested as an effective biomaterial to remove Pb(II) and Cd(II) ions in aqueous solutions.	Alginates	16-19	submaxillary gland androgen regulated protein 3B	Homo sapiens	172-189
30396234-4	2018	Bone morphogenic proteins (BMP-2) and indispensable ECM proteins both directed differentiation inside alginate beads.	Alginates	102-110	bone morphogenetic protein 2	Homo sapiens	27-32
30629543-1	2018	An efficient biosorbent containing magnetic nanoparticles, walnut shell powder, foam, and alginate (AMWSF) was prepared and used in Pb(II) removal.	Alginates	90-98	submaxillary gland androgen regulated protein 3B	Homo sapiens	132-138
30380888-9	2018	Multiscale anisotropy together with the capability of the MNP-containing alginate scaffolds to undergo reversible shape deformation in an oscillating magnetic field creates interesting opportunities for multifarious stimulation of cells and functional tissue development.	Alginates	73-81	modifier of Niemann Pick type C1	Mus musculus	58-61
30346766-0	2018	Development of pH Sensitive Alginate/Gum Tragacanth Based Hydrogels for Oral Insulin Delivery.	Alginates	28-36	insulin	Homo sapiens	77-84
30346766-1	2018	Insulin entrapped alginate-gum tragacanth (ALG-GT) hydrogels at different ALG replacement ratios (100, 75, 50, 25) were prepared through an ionotropic gelation method, followed by chitosan (CH) polyelectrolyte complexation.	Alginates	18-26	insulin	Homo sapiens	0-7
30396234-6	2018	Augmentation of alginate is necessary, and we showed that a few rationally selected small proteins from the basement membrane (BM) compartment of the ECM were sufficient to upregulate cell expression of Runx-2 and osteocalcin for osteoid formation, resulting in Alizarin red-positive mineral nodules.	Alginates	16-24	RUNX family transcription factor 2	Homo sapiens	203-209
30396234-6	2018	Augmentation of alginate is necessary, and we showed that a few rationally selected small proteins from the basement membrane (BM) compartment of the ECM were sufficient to upregulate cell expression of Runx-2 and osteocalcin for osteoid formation, resulting in Alizarin red-positive mineral nodules.	Alginates	16-24	bone gamma-carboxyglutamate protein	Homo sapiens	214-225
29250977-8	2018	Results indicate that induction of M2 phenotype by IL-10 addition in the alginate matrix produces anti-inflammatory cytokines and increases the metabolic activity and the viability of the encapsulated macrophages.	Alginates	73-81	interleukin 10	Homo sapiens	51-56
30230271-6	2018	Alginate formulations show sustained release of BMP-2, while there is minimal release from HApN.	Alginates	0-8	bone morphogenetic protein 2	Rattus norvegicus	48-53
30107214-8	2018	More importantly, oral administration of Gal-siTNF-NPs plus IL-22 embedded in a hydrogel (chitosan/alginate) showed much stronger capacities to down-regulate the expression of pro-inflammatory factors and promote mucosal healing.	Alginates	99-107	interleukin 22	Mus musculus	60-65
30093005-7	2018	The alginate/CNF composite materials have potentials to be used in applications where good swelling and mechanical robustness are required.	Alginates	4-12	NPHS1 adhesion molecule, nephrin	Homo sapiens	13-16
29855096-3	2018	In this work, N-carboxymethyl chitosan- and alginate-based hydrogels are prepared via both electrostatic interaction and divalent chelation with epidermal growth factor (EGF) payload to promote the cell proliferation and wound healing.	Alginates	44-52	epidermal growth factor	Homo sapiens	145-168
30524677-0	2018	Effects of insulin-loaded chitosan-alginate nanoparticles on RAGE expression and oxidative stress status in the kidney tissue of rats with type 1 diabetes.	Alginates	35-43	advanced glycosylation end product-specific receptor	Rattus norvegicus	61-65
28707514-4	2018	ARI-1, was immobilized in calcium alginate (CA) using an embedding method and applied to the removal of estrogens from natural sewage and cow dung.	Alginates	26-42	ariadne RBR E3 ubiquitin protein ligase 1	Bos taurus	0-5
29790251-6	2018	The BMP-2-encapsulated BSA nanoparticles were prepared via a desolvation method and then coated with CS and oxidized alginate to achieve sustained release of BMP-2.	Alginates	117-125	bone morphogenetic protein 2	Homo sapiens	4-9
29855096-3	2018	In this work, N-carboxymethyl chitosan- and alginate-based hydrogels are prepared via both electrostatic interaction and divalent chelation with epidermal growth factor (EGF) payload to promote the cell proliferation and wound healing.	Alginates	44-52	epidermal growth factor	Homo sapiens	170-173
29891290-0	2018	Three dimensional cell printing with sulfated alginate for improved bone morphogenetic protein-2 delivery and osteogenesis in bone tissue engineering.	Alginates	46-54	bone morphogenetic protein 2	Homo sapiens	68-96
30350551-3	2018	Herein, an ice-templating strategy is developed to prepare CoP aerogels composed of 2D ultrathin CoP nanosheets (&lt;1.5 nm) using sustainable alginate biomass (seaweed extract) as the precursor.	Alginates	143-151	caspase recruitment domain family member 16	Homo sapiens	59-62
30125096-0	2018	Cell-Instructive Alginate Hydrogels Targeting RhoA.	Alginates	17-25	ras homolog family member A	Mus musculus	46-50
30125096-5	2018	In this study, a novel alginate-derived hydrogel system was developed for sustained RhoA targeting.	Alginates	23-31	ras homolog family member A	Mus musculus	84-88
29891290-6	2018	Moreover, alginate/alginate-sulfate bio-inks exhibited an improved retention of bone morphogenetic protein 2 in 3D-printed scaffolds.	Alginates	10-18	bone morphogenetic protein 2	Homo sapiens	80-108
29891290-6	2018	Moreover, alginate/alginate-sulfate bio-inks exhibited an improved retention of bone morphogenetic protein 2 in 3D-printed scaffolds.	Alginates	19-27	bone morphogenetic protein 2	Homo sapiens	80-108
29679826-2	2018	Compared with the virgin membrane, the modified NF90 membrane exhibited considerably improved fouling resistance and an increased reversible fouling percentage, especially for SA+HA composite fouling Moreover, the PPCP removal of the modified NF90 membrane was higher than that of the virgin membrane after SA and SA+HA fouling, respectively.	Alginates	176-178	interleukin enhancer binding factor 3	Homo sapiens	48-52
30113159-8	2018	Furthermore, a sodium alginate hydrogel containing both BG and DFO was developed, and this hydrogel better facilitated diabetic skin wound healing than the use of either BG or DFO alone as BG and DFO in the hydrogels worked synergistically in promoting HIF-1alpha and VEGF expression and subsequently vascularization in the wound sites.	Alginates	15-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	253-263
30113159-8	2018	Furthermore, a sodium alginate hydrogel containing both BG and DFO was developed, and this hydrogel better facilitated diabetic skin wound healing than the use of either BG or DFO alone as BG and DFO in the hydrogels worked synergistically in promoting HIF-1alpha and VEGF expression and subsequently vascularization in the wound sites.	Alginates	15-30	vascular endothelial growth factor A	Homo sapiens	268-272
30723680-3	2019	Methods: The affinity-binding alginate hydrogel is designed for presentation and slow release of chondrogenic and osteogenic inducers (transforming growth factor-beta1 and bone morphogenic protein 4, respectively) in two distinct and separate hydrogel layers.	Alginates	30-38	transforming growth factor beta 1	Sus scrofa	97-167
30246698-10	2018	Particulate alginate induced the most potent inflammatory reaction as determined by the production of cytokines, such as, IL-1beta, IL-8, TNF-alpha and IFN-gamma.	Alginates	12-20	interleukin 1 beta	Mus musculus	122-130
30246698-10	2018	Particulate alginate induced the most potent inflammatory reaction as determined by the production of cytokines, such as, IL-1beta, IL-8, TNF-alpha and IFN-gamma.	Alginates	12-20	chemokine (C-X-C motif) ligand 15	Mus musculus	132-136
30246698-10	2018	Particulate alginate induced the most potent inflammatory reaction as determined by the production of cytokines, such as, IL-1beta, IL-8, TNF-alpha and IFN-gamma.	Alginates	12-20	tumor necrosis factor	Mus musculus	138-147
30246698-10	2018	Particulate alginate induced the most potent inflammatory reaction as determined by the production of cytokines, such as, IL-1beta, IL-8, TNF-alpha and IFN-gamma.	Alginates	12-20	interferon gamma	Mus musculus	152-161
30246698-11	2018	Low viscosity and particulate alginates are more effective than high viscosity alginates in activating dendritic cells as indicated by the expression of dendritic cells surface markers (CD80, CD86 and CD40).	Alginates	30-39	CD80 antigen	Mus musculus	186-190
30246698-11	2018	Low viscosity and particulate alginates are more effective than high viscosity alginates in activating dendritic cells as indicated by the expression of dendritic cells surface markers (CD80, CD86 and CD40).	Alginates	30-39	CD86 antigen	Mus musculus	192-196
30246698-11	2018	Low viscosity and particulate alginates are more effective than high viscosity alginates in activating dendritic cells as indicated by the expression of dendritic cells surface markers (CD80, CD86 and CD40).	Alginates	30-39	CD40 antigen	Mus musculus	201-205
30246698-12	2018	Similarly, the level of G-CSF was slightly higher in particulate alginate treated macrophages.	Alginates	65-73	peripheral blood stem cell response to granulocyte colony stimulating factor 1	Mus musculus	24-29
30146922-0	2018	Cell encapsulation potential of chitosan-alginate electrostatic complex in preventing natural killer and CD8+ cell-mediated cytotoxicity: an in vitro experimental study.	Alginates	41-49	CD8a molecule	Homo sapiens	105-108
29873069-2	2018	Since cartilage is not spontaneously regenerated, our group has recently developed a strategy of injecting bioactive alginate hydrogel into the defect for promoting endogenous regeneration of cartilage via presentation of affinity-bound transforming growth factor beta1 (TGF-beta1).	Alginates	117-125	transforming growth factor beta 1	Homo sapiens	237-269
29873069-2	2018	Since cartilage is not spontaneously regenerated, our group has recently developed a strategy of injecting bioactive alginate hydrogel into the defect for promoting endogenous regeneration of cartilage via presentation of affinity-bound transforming growth factor beta1 (TGF-beta1).	Alginates	117-125	transforming growth factor beta 1	Homo sapiens	271-280
30524693-12	2018	Both UCSCs and HLCs encapsulated in alginate scaffolds effectively attenuated biochemical tests, improved liver cytoarchitecture, increased expression of ALB and reduced AFP expression.	Alginates	36-44	albumin	Rattus norvegicus	154-157
30524693-12	2018	Both UCSCs and HLCs encapsulated in alginate scaffolds effectively attenuated biochemical tests, improved liver cytoarchitecture, increased expression of ALB and reduced AFP expression.	Alginates	36-44	alpha-fetoprotein	Rattus norvegicus	170-173
30524693-13	2018	Conclusion: Finding of the present study indicated that encapsulation of UCSCs or HLCs in alginate mannuronic scaffolds effectively improve CCl4-induced ALF.	Alginates	90-98	C-C motif chemokine ligand 4	Rattus norvegicus	140-144
29679826-2	2018	Compared with the virgin membrane, the modified NF90 membrane exhibited considerably improved fouling resistance and an increased reversible fouling percentage, especially for SA+HA composite fouling Moreover, the PPCP removal of the modified NF90 membrane was higher than that of the virgin membrane after SA and SA+HA fouling, respectively.	Alginates	176-178	interleukin enhancer binding factor 3	Homo sapiens	243-247
29679826-2	2018	Compared with the virgin membrane, the modified NF90 membrane exhibited considerably improved fouling resistance and an increased reversible fouling percentage, especially for SA+HA composite fouling Moreover, the PPCP removal of the modified NF90 membrane was higher than that of the virgin membrane after SA and SA+HA fouling, respectively.	Alginates	307-309	interleukin enhancer binding factor 3	Homo sapiens	48-52
29679826-2	2018	Compared with the virgin membrane, the modified NF90 membrane exhibited considerably improved fouling resistance and an increased reversible fouling percentage, especially for SA+HA composite fouling Moreover, the PPCP removal of the modified NF90 membrane was higher than that of the virgin membrane after SA and SA+HA fouling, respectively.	Alginates	307-309	interleukin enhancer binding factor 3	Homo sapiens	243-247
29679826-2	2018	Compared with the virgin membrane, the modified NF90 membrane exhibited considerably improved fouling resistance and an increased reversible fouling percentage, especially for SA+HA composite fouling Moreover, the PPCP removal of the modified NF90 membrane was higher than that of the virgin membrane after SA and SA+HA fouling, respectively.	Alginates	307-309	interleukin enhancer binding factor 3	Homo sapiens	48-52
29679826-2	2018	Compared with the virgin membrane, the modified NF90 membrane exhibited considerably improved fouling resistance and an increased reversible fouling percentage, especially for SA+HA composite fouling Moreover, the PPCP removal of the modified NF90 membrane was higher than that of the virgin membrane after SA and SA+HA fouling, respectively.	Alginates	307-309	interleukin enhancer binding factor 3	Homo sapiens	243-247
29622193-1	2018	In order to develop an accurate and precise determination method based on solid phase extraction of Pb(II) in food and water samples, a hybrid monolithic column based on layered double hydroxides (LDHs) nanosheets-alginate hydrogel has been synthesized.	Alginates	214-222	submaxillary gland androgen regulated protein 3B	Homo sapiens	100-106
29998679-0	2018	[Preparation and Characterization of a Calcium Alginate/Biochar Microsphere and Its Adsorption Characteristics and Mechanisms for Pb(II)].	Alginates	39-55	submaxillary gland androgen regulated protein 3B	Homo sapiens	130-137
29998679-1	2018	A microsphere (CA/BC) was prepared using biochar (BC) encapsulated with calcium alginate (CA) as a green adsorbent for Pb(II) removal from aqueous solution.	Alginates	72-88	submaxillary gland androgen regulated protein 3B	Homo sapiens	119-125
29752096-2	2018	In the present study, graphene oxide (GO) was encapsulated into environmentally benign sodium alginate (SA) to prepare a Ca2+ crosslinked alginate/graphene oxide composite gel beads (Ca-SA/GO) which were then used to adsorb lysozyme from aqueous solutions.	Alginates	104-106	casein alpha s1	Homo sapiens	183-191
30814893-5	2018	eTh polymerization of alginate with PRP enhanced the viability up to 61% in the alginate microbeads.	Alginates	22-30	proline rich protein 2-like 1	Rattus norvegicus	36-39
30814893-5	2018	eTh polymerization of alginate with PRP enhanced the viability up to 61% in the alginate microbeads.	Alginates	80-88	proline rich protein 2-like 1	Rattus norvegicus	36-39
30814893-6	2018	PRP supplementation to the alginate composition not only increased the number of viable cells by 1.95-fold, but the insulin secretion also improved by about 66%.	Alginates	27-35	proline rich protein 2-like 1	Rattus norvegicus	0-3
29996652-0	2018	Alginate-C18 Conjugate Nanoparticles Loaded in Tripolyphosphate-Cross-Linked Chitosan-Oleic Acid Conjugate-Coated Calcium Alginate Beads as Oral Insulin Carrier.	Alginates	0-8	Bardet-Biedl syndrome 9	Homo sapiens	9-12
29996652-0	2018	Alginate-C18 Conjugate Nanoparticles Loaded in Tripolyphosphate-Cross-Linked Chitosan-Oleic Acid Conjugate-Coated Calcium Alginate Beads as Oral Insulin Carrier.	Alginates	0-8	insulin	Homo sapiens	145-152
29996652-0	2018	Alginate-C18 Conjugate Nanoparticles Loaded in Tripolyphosphate-Cross-Linked Chitosan-Oleic Acid Conjugate-Coated Calcium Alginate Beads as Oral Insulin Carrier.	Alginates	114-130	Bardet-Biedl syndrome 9	Homo sapiens	9-12
29996652-0	2018	Alginate-C18 Conjugate Nanoparticles Loaded in Tripolyphosphate-Cross-Linked Chitosan-Oleic Acid Conjugate-Coated Calcium Alginate Beads as Oral Insulin Carrier.	Alginates	114-130	insulin	Homo sapiens	145-152
29996652-3	2018	Alginate-C18 conjugate nanoparticles were nontoxic.	Alginates	0-8	Bardet-Biedl syndrome 9	Homo sapiens	9-12
29996652-5	2018	Their insulin reabsorption tendency was minimized as alginate active COOH/COO- sites were preoccupied with C18.	Alginates	53-61	insulin	Homo sapiens	6-13
29996652-5	2018	Their insulin reabsorption tendency was minimized as alginate active COOH/COO- sites were preoccupied with C18.	Alginates	53-61	Bardet-Biedl syndrome 9	Homo sapiens	107-110
30154869-4	2018	Hydroxyapatite (HAp) can support alginate as inorganic reinforcement and osteoconductive component of alginate/HAp composite scaffolds.	Alginates	33-41	reticulon 3	Homo sapiens	16-19
30154869-4	2018	Hydroxyapatite (HAp) can support alginate as inorganic reinforcement and osteoconductive component of alginate/HAp composite scaffolds.	Alginates	33-41	reticulon 3	Homo sapiens	111-114
30154869-4	2018	Hydroxyapatite (HAp) can support alginate as inorganic reinforcement and osteoconductive component of alginate/HAp composite scaffolds.	Alginates	102-110	reticulon 3	Homo sapiens	16-19
30154869-6	2018	In the present work, HAp was incorporated into an alginate solution and internal gelling was induced by addition of slowly acid-hydrolyzing D-gluconic acid delta-lactone for the direct release of calcium ions from HAp.	Alginates	50-58	reticulon 3	Homo sapiens	21-24
29752096-3	2018	Compared with pure Ca2+ crosslinked alginate gel beads (Ca-SA), the as-prepared Ca-SA/GO has a lower swelling degree, an improved gel stability in salt solutions, and a higher mechanical performance.	Alginates	36-44	casein alpha s1	Homo sapiens	80-88
29732529-0	2018	Osteostimulation scaffolds of stem cells: BMP-7-derived peptide-decorated alginate porous scaffolds promote the aggregation and osteo-differentiation of human mesenchymal stem cells.	Alginates	74-82	bone morphogenetic protein 7	Homo sapiens	42-47
29932320-10	2018	Moreover, the lipid metabolism disorder and organ damage of diabetic mice were alleviated after treatment with SA/CPBA-MSN/INS.	Alginates	111-113	moesin	Mus musculus	119-122
29661473-5	2018	GLUT2 transporter expression on the cell surface of islets exposed to silk was increased compared to alginate or medium alone.	Alginates	101-109	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	0-5
30002278-4	2018	Results: CRC cells cultured in alginate were able to migrate from alginate and the numbers of migrated cells were significantly increased in the presence of TNF-beta, similar to TNF-alpha, and dramatically decreased by resveratrol.	Alginates	31-39	lymphotoxin alpha	Homo sapiens	157-165
29905934-1	2018	The goal of our study was to investigate the effect of alginate on in vitro gastric digestion and sucrose release of soy protein isolate (SPI) in model beverages.	Alginates	55-63	chromogranin A	Homo sapiens	138-141
29905934-6	2018	SPI beverages formed intragastric gel during in vitro gastric digestion when the formulations contained alginate or at pH 6.0 without alginate.	Alginates	104-112	chromogranin A	Homo sapiens	0-3
29905934-6	2018	SPI beverages formed intragastric gel during in vitro gastric digestion when the formulations contained alginate or at pH 6.0 without alginate.	Alginates	134-142	chromogranin A	Homo sapiens	0-3
29905934-9	2018	This suggests that electrostatic interaction between SPI and alginate that occurred when the beverages were under gastric condition could be responsible for the intragastric gelation.	Alginates	61-69	chromogranin A	Homo sapiens	53-56
29574641-0	2018	High performance of 3D porous graphene/lignin/sodium alginate composite for adsorption of Cd(II) and Pb(II).	Alginates	46-61	submaxillary gland androgen regulated protein 3B	Homo sapiens	90-107
29761603-5	2018	Inspired by mucin, the amphiphilic macromolecular lubricant, secreted on the hydrophobic surface of gastrointestine to interface aqueous serous fluid, here, a renatured DNA-alginate amphiphilic binder for silicon and silicon-graphite blended electrodes is reported.	Alginates	173-181	LOC100508689	Homo sapiens	12-17
29761603-6	2018	Mimicking mucin"s structure comprised of a hydrophobic protein backbone and hydrophilic oligosaccharide branches, the renatured DNA-alginate binder offers amphiphilicity from both components, along with a 3D fractal network structure.	Alginates	132-140	LOC100508689	Homo sapiens	10-15
29510369-4	2018	To solve these issues, novel sodium alginate/graphene oxide hydrogel beads (GSA) were synthesised and their effectiveness as permeable reactive barrier (PRB) backfill material in the remediation of ciprofloxacin (CPX)-contaminated groundwater was tested.	Alginates	29-44	GNAS complex locus	Homo sapiens	76-79
29697853-0	2018	Injectable BMP-2 delivery system based on collagen-derived microspheres and alginate induced bone formation in a time- and dose-dependent manner.	Alginates	76-84	bone morphogenetic protein 2	Rattus norvegicus	11-16
29261011-8	2018	Particularly, alginate synthesis, syringafactin production, and virulence are considerably de-repressed in a csrA3 mutant, whereas growth in planta is impaired.	Alginates	14-22	carbon storage regulator CsrA	Pseudomonas syringae pv. tomato str. DC3000	109-114
29522657-2	2018	The three-dimensional alginate scaffolds with co-administration of PRP and/or chondrogenic supplements had a significant effect on the differentiation of adipose mesenchymal stem cells into mature cartilage, as assessed by an evaluation of the expression of cartilage-related markers of Sox9, collagen II, aggrecan and collagen, and glycosaminoglycan assays.	Alginates	22-30	SRY-box transcription factor 9	Homo sapiens	287-291
29567197-0	2018	Bone regeneration in osteoporosis by delivery BMP-2 and PRGF from tetronic-alginate composite thermogel.	Alginates	75-83	bone morphogenetic protein 2	Rattus norvegicus	46-51
29701967-1	2018	Insulin and an antacid [Mg(OH)2] were co-encapsulated inside calcium alginate microgels (diameter = 280 mum) using a vibrating nozzle injector.	Alginates	61-77	insulin	Homo sapiens	0-7
29543511-0	2018	Sustained Delivery of Transforming Growth Factor beta1 by Use of Absorbable Alginate Scaffold Enhances Rotator Cuff Healing in a Rabbit Model.	Alginates	76-84	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	22-54
29543511-2	2018	PURPOSE: To establish a system for sustained release of transforming growth factor beta1 (TGF-beta1) using an alginate scaffold and evaluate the effects of the sustained release of TGF-beta1 on rotator cuff healing in a rabbit model.	Alginates	110-118	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	56-88
29543511-2	2018	PURPOSE: To establish a system for sustained release of transforming growth factor beta1 (TGF-beta1) using an alginate scaffold and evaluate the effects of the sustained release of TGF-beta1 on rotator cuff healing in a rabbit model.	Alginates	110-118	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	90-99
29543511-5	2018	Additionally, an enzyme-linked immunosorbent assay was performed to confirm the capacity of the sustained release of TGF-beta1-containing alginate scaffold.	Alginates	138-146	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	117-126
29543511-9	2018	Additionally, the level of TGF-beta1 was found to increase with time on the alginate scaffold.	Alginates	76-84	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	27-36
29543511-14	2018	CONCLUSION: At 12 weeks after rotator cuff repair, the authors found improved biomechanical and histological outcomes for sustained release of TGF-beta1 using alginate scaffold in a rabbit model.	Alginates	159-167	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	143-152
29449216-0	2018	Adjustable delivery of pro-angiogenic FGF-2 by alginate:collagen microspheres.	Alginates	47-55	fibroblast growth factor 2	Mus musculus	38-43
32254361-3	2018	In this study, an injectable hydrogel SAG system containing sodium alginate, akermanite and glutamate was prepared and evaluated in such defects.	Alginates	60-75	S-antigen visual arrestin	Homo sapiens	38-41
31352939-3	2018	To overcome these limitations, in this study, we developed a novel mesoporous silica (MS)-based calcium alginate nanohybrid granule (p-MS/CA) for hemorrhage control.	Alginates	96-112	proline rich protein BstNI subfamily 1	Homo sapiens	133-137
29490139-4	2018	The metals or metal oxide nanoparticles arising from alginates could catalyze the pyrolysis intermediates of EVA into graphene and amorphous carbon, which could bind the inorganic compounds (the decomposition products of MH and APTES) together and form some more protective barriers.	Alginates	53-62	myelin protein zero like 2	Homo sapiens	109-112
29460309-0	2018	Entrapment of LTB protein in alginate nanoparticles protects against Enterotoxigenic Escherichia coli.	Alginates	29-37	lymphotoxin B	Mus musculus	14-17
29460309-4	2018	In this study, feasibility of alginate nanoparticles (NPs) such as recombinant LTB from Enterotoxigenic Escherichia coli (ETEC) carrier was investigated.	Alginates	30-38	lymphotoxin B	Mus musculus	79-82
29460309-9	2018	LTB protein was expressed and efficiently entrapped into the alginate NPs.	Alginates	61-69	lymphotoxin B	Mus musculus	0-3
28438077-0	2018	Molecular dynamics simulations reveal the influence of dextran sulfate in nanoparticle formation with calcium alginate to encapsulate insulin.	Alginates	102-118	insulin	Homo sapiens	134-141
29489360-1	2018	Beta-lactoglobulin (BLG) and bovine serum albumin (BSA) coacervate formation with sodium alginate (ALG) was investigated by turbidimetric analysis, zeta potential, particle size, viscosity, transmission electron microscopy (TEM) and isothermal titration calorimetric (ITC) measurements as a function of pH (1.0-7.0) and protein/alginate mixing ratio (1:1, 1.5:1, 2:1, 1:0, and 0:1 wt.).	Alginates	82-97	albumin	Homo sapiens	36-49
29489360-1	2018	Beta-lactoglobulin (BLG) and bovine serum albumin (BSA) coacervate formation with sodium alginate (ALG) was investigated by turbidimetric analysis, zeta potential, particle size, viscosity, transmission electron microscopy (TEM) and isothermal titration calorimetric (ITC) measurements as a function of pH (1.0-7.0) and protein/alginate mixing ratio (1:1, 1.5:1, 2:1, 1:0, and 0:1 wt.).	Alginates	99-102	albumin	Homo sapiens	36-49
29489360-1	2018	Beta-lactoglobulin (BLG) and bovine serum albumin (BSA) coacervate formation with sodium alginate (ALG) was investigated by turbidimetric analysis, zeta potential, particle size, viscosity, transmission electron microscopy (TEM) and isothermal titration calorimetric (ITC) measurements as a function of pH (1.0-7.0) and protein/alginate mixing ratio (1:1, 1.5:1, 2:1, 1:0, and 0:1 wt.).	Alginates	89-97	albumin	Homo sapiens	36-49
29449216-3	2018	Here, we demonstrate that alginate:collagen hydrogels containing therapeutic, pro-angiogenic FGF-2, and formulated as microspheres, is a promising and clinically relevant vehicle for therapeutic angiogenesis.	Alginates	26-34	fibroblast growth factor 2	Mus musculus	93-98
29449216-4	2018	By titrating the amount of readily dissolvable and degradable collagen with more slowly degradable alginate in the hydrogel mixture, the degradation rates of the biomaterial controlling the release kinetics of embedded pro-angiogenic FGF-2 can be adjusted.	Alginates	99-107	fibroblast growth factor 2	Mus musculus	234-239
29756517-4	2018	A central cavity in the scaffold holds a 2-mm diameter alginate sphere for controlled release of the angiogenic cytokine vascular endothelial growth factor ( VEGF).	Alginates	55-63	vascular endothelial growth factor A	Mus musculus	158-162
28815373-6	2018	Gene expression analysis at different time point (day 1, 7, 14) showed that 3D culture of NCs in alginate up-regulated chondrogenic markers (Col2A1, ACAN SOX9), meanwhile down-regulated dedifferentiation related gene (Col1A1).	Alginates	97-105	collagen alpha-1(II) chain	Oryctolagus cuniculus	141-147
28815373-6	2018	Gene expression analysis at different time point (day 1, 7, 14) showed that 3D culture of NCs in alginate up-regulated chondrogenic markers (Col2A1, ACAN SOX9), meanwhile down-regulated dedifferentiation related gene (Col1A1).	Alginates	97-105	collagen alpha-1(I) chain	Oryctolagus cuniculus	218-224
29195799-0	2018	Fabrication of carboxylated cellulose nanocrystal/sodium alginate hydrogel beads for adsorption of Pb(II) from aqueous solution.	Alginates	50-65	submaxillary gland androgen regulated protein 3B	Homo sapiens	99-105
28805303-1	2018	OBJECTIVES: To determine the effects of controlled release of insulin-like growth factor 1 (IGF-1) from alginate-poly-L-ornithine-gelatine (A-PLO-G) microbeads on external urethral sphincter (EUS) tissue regeneration in a rat model of stress urinary incontinence (SUI), as SUI diminishes the quality of life of millions, particularly women who have delivered vaginally, which can injure the urethral sphincter.	Alginates	104-112	insulin-like growth factor 1	Rattus norvegicus	62-90
29460181-7	2018	Overall, interleukin-2 (IL-2) secretions as a response of the immune system revealed that mESCs microencapsulation in alginate-TMC-PEG, reduced the immune system response.	Alginates	118-126	interleukin 2	Mus musculus	9-22
29460181-7	2018	Overall, interleukin-2 (IL-2) secretions as a response of the immune system revealed that mESCs microencapsulation in alginate-TMC-PEG, reduced the immune system response.	Alginates	118-126	interleukin 2	Mus musculus	24-28
29964850-1	2018	The linear relationship between the concentration of either bovine serum albumin (BSA) or sodium alginate (SA) and the intensity of a resonance light scattering (RLS) spectrum was established by using Congo red and neutral red as the dye probes, respectively.	Alginates	83-85	albumin	Homo sapiens	67-80
28805303-1	2018	OBJECTIVES: To determine the effects of controlled release of insulin-like growth factor 1 (IGF-1) from alginate-poly-L-ornithine-gelatine (A-PLO-G) microbeads on external urethral sphincter (EUS) tissue regeneration in a rat model of stress urinary incontinence (SUI), as SUI diminishes the quality of life of millions, particularly women who have delivered vaginally, which can injure the urethral sphincter.	Alginates	104-112	insulin-like growth factor 1	Rattus norvegicus	92-97
29208279-8	2018	Lower expression of Col1a1, the fibrocartilage marker, was present in SA/COL group than that in both of SA and SA/AG groups.	Alginates	70-72	collagen type I alpha 1 chain	Homo sapiens	20-26
29254056-5	2018	The crosslinking mechanism was based on ionic interactions, with accompanying weaker interactions specific for each crosslinker, and involved characteristic macroscopic association constants (Ka1) for complexation of alginate (range, 104-109M-1).	Alginates	217-225	glutamate ionotropic receptor kainate type subunit 4	Homo sapiens	192-195
29208279-8	2018	Lower expression of Col1a1, the fibrocartilage marker, was present in SA/COL group than that in both of SA and SA/AG groups.	Alginates	104-106	collagen type I alpha 1 chain	Homo sapiens	20-26
29208279-8	2018	Lower expression of Col1a1, the fibrocartilage marker, was present in SA/COL group than that in both of SA and SA/AG groups.	Alginates	104-106	collagen type I alpha 1 chain	Homo sapiens	20-26
28961808-8	2018	In vivo, oral administration of NPs-PEG-FA/6-shogaol encapsulated in a hydrogel system [chitosan/alginate] significantly alleviated colitis symptoms and accelerated colitis wound repair in DSS-treated mice by regulating the expression levels of pro-inflammatory [TNF-alpha, IL-6, IL-1beta, and iNOS] and anti-inflammatory [Nrf-2 and HO-1] factors.	Alginates	97-105	tumor necrosis factor	Mus musculus	263-272
27863118-8	2018	The release rate of NGF from the microspheres was controlled by the alginate concentration and the poly(L-lysine) coating.	Alginates	68-76	nerve growth factor	Rattus norvegicus	20-23
29144959-7	2018	Encapsulation of Aldh1a1-/- adipocytes into alginate poly-L-lysine microcapsules induced functional innervation of adipose tissue in obese wild-type mice.	Alginates	44-52	aldehyde dehydrogenase family 1, subfamily A1	Mus musculus	17-24
27863118-0	2018	Nanofibrous gelatine scaffolds integrated with nerve growth factor-loaded alginate microspheres for brain tissue engineering.	Alginates	74-82	nerve growth factor	Rattus norvegicus	47-66
27863118-4	2018	To promote tissue regeneration processes, the scaffolds were integrated with nerve growth factor (NGF)-loaded alginate microspheres.	Alginates	110-118	nerve growth factor	Rattus norvegicus	77-96
27863118-4	2018	To promote tissue regeneration processes, the scaffolds were integrated with nerve growth factor (NGF)-loaded alginate microspheres.	Alginates	110-118	nerve growth factor	Rattus norvegicus	98-101
27863118-7	2018	The encapsulation efficiencies of NGF into 0.1% and 1% alginate microspheres were 85% and 100%, respectively.	Alginates	55-63	nerve growth factor	Rattus norvegicus	34-37
28961808-8	2018	In vivo, oral administration of NPs-PEG-FA/6-shogaol encapsulated in a hydrogel system [chitosan/alginate] significantly alleviated colitis symptoms and accelerated colitis wound repair in DSS-treated mice by regulating the expression levels of pro-inflammatory [TNF-alpha, IL-6, IL-1beta, and iNOS] and anti-inflammatory [Nrf-2 and HO-1] factors.	Alginates	97-105	interleukin 6	Mus musculus	274-278
28961808-8	2018	In vivo, oral administration of NPs-PEG-FA/6-shogaol encapsulated in a hydrogel system [chitosan/alginate] significantly alleviated colitis symptoms and accelerated colitis wound repair in DSS-treated mice by regulating the expression levels of pro-inflammatory [TNF-alpha, IL-6, IL-1beta, and iNOS] and anti-inflammatory [Nrf-2 and HO-1] factors.	Alginates	97-105	interleukin 1 beta	Mus musculus	280-288
28961808-8	2018	In vivo, oral administration of NPs-PEG-FA/6-shogaol encapsulated in a hydrogel system [chitosan/alginate] significantly alleviated colitis symptoms and accelerated colitis wound repair in DSS-treated mice by regulating the expression levels of pro-inflammatory [TNF-alpha, IL-6, IL-1beta, and iNOS] and anti-inflammatory [Nrf-2 and HO-1] factors.	Alginates	97-105	nitric oxide synthase 2, inducible	Mus musculus	294-298
28961808-8	2018	In vivo, oral administration of NPs-PEG-FA/6-shogaol encapsulated in a hydrogel system [chitosan/alginate] significantly alleviated colitis symptoms and accelerated colitis wound repair in DSS-treated mice by regulating the expression levels of pro-inflammatory [TNF-alpha, IL-6, IL-1beta, and iNOS] and anti-inflammatory [Nrf-2 and HO-1] factors.	Alginates	97-105	nuclear factor, erythroid derived 2, like 2	Mus musculus	323-328
28972200-0	2018	Fibrinogen-modified sodium alginate as a scaffold material for skin tissue engineering.	Alginates	20-35	fibrinogen beta chain	Homo sapiens	0-10
28972200-1	2018	In search for a new pro-angiogenic scaffold material suitable for skin bioengineering and grafting therapy, we have fabricated a number of composite sodium alginate (AG)-fibrinogen (FG) sponge scaffolds using the freeze-drying approach.	Alginates	149-164	fibrinogen beta chain	Homo sapiens	170-180
28972200-10	2018	Altogether, obtained results suggest that thrombin-modified alginate sponges can be successfully used as a grafting material by itself to promote skin healing and regeneration and also as a scaffold for three-dimensional bioequivalent construction.	Alginates	60-68	coagulation factor II, thrombin	Homo sapiens	42-50
28882767-0	2018	Optimization of alginate microcapsules containing cells overexpressing alpha-l-iduronidase using Box-Behnken design.	Alginates	16-24	iduronidase, alpha-L	Mus musculus	71-90
29174589-5	2018	Using a focal adhesion kinase (FAK) inhibitor, we demonstrated that focal adhesion signaling is involved in the response of NP cells in hydrogels that contain integrin binding sites (i.e. methacrylated gelatin (gelMA) and type II collagen), but not in hydrogels deplete from integrin binding sites such as alginate and agarose, or CD44-binding hydrogels based on hyaluronic acid.	Alginates	306-314	protein tyrosine kinase 2	Homo sapiens	31-34
29384064-0	2018	Investigating the Therapeutic Effects of Alginate Nanogel Co-loaded with Gold Nanoparticles and Cisplatin on U87-MG Human Glioblastoma Cells.	Alginates	41-49	small nucleolar RNA, C/D box 87	Homo sapiens	109-112
29384064-2	2018	In this in vitro study, we investigated the chemoradiotherapeutic effects of alginate nanogel co-loaded with AuNPs and cisplatin (ACA) on U87-MG human glioblastoma cells.	Alginates	77-85	small nucleolar RNA, C/D box 87	Homo sapiens	138-141
28873532-0	2018	Effect of sodium alginate with three molecular weight forms on the water holding capacity of chicken breast myosin gel.	Alginates	10-25	myosin, heavy chain 15	Gallus gallus	108-114
28873532-2	2018	The results showed that 0.1-0.5% SA of three molecular-weights increased the WHC of myosin-SA gels, and the heavier SA induced a higher WHC.	Alginates	33-35	myosin, heavy chain 15	Gallus gallus	84-90
28873532-2	2018	The results showed that 0.1-0.5% SA of three molecular-weights increased the WHC of myosin-SA gels, and the heavier SA induced a higher WHC.	Alginates	91-93	myosin, heavy chain 15	Gallus gallus	84-90
28873532-3	2018	Electrostatic-interactions and hydrogen-bonding contributed to the intermolecular aggregation in the myosin-SA system and enhanced its intermolecular interactions by overcoming the steric hindrance effect of SA with heavier molecules.	Alginates	108-110	myosin, heavy chain 15	Gallus gallus	101-107
29080455-0	2018	In vitro and in vivo toxicity assessment of alginate/eudragit S 100-enclosed chitosan-calcium phosphate-loaded iron saturated bovine lactoferrin nanocapsules (Fe-bLf NCs).	Alginates	44-52	lactotransferrin	Bos taurus	133-144
28882767-5	2018	The optimal conditions of voltage (10kV), flow (25mL/h), and alginate concentration (1.3%) made possible to obtain the smallest microcapsules showing the highest IDUA activity.	Alginates	61-69	iduronidase, alpha-L	Mus musculus	162-166
28739412-0	2017	Alginate enhances Toll-like receptor 4-mediated phagocytosis by murine RAW264.7 macrophages.	Alginates	0-8	toll-like receptor 4	Mus musculus	18-38
26424392-0	2018	Alginate Bead-Encapsulated PEDF Induces Ectopic Bone Formation In Vivo in the Absence of Co-Administered Mesenchymal Stem Cells.	Alginates	0-8	serpin family F member 1	Homo sapiens	27-31
26424392-4	2018	OBJECTIVE: We demonstrate that pigment epithelium-derived factor (PEDF), one such factor that is known to be potent against angiogenesis, promotes osteoblastogenesis in mesenchymal stem cells in vitro, but does not need co-encapsulation of cells in alginate bead scaffolds for osteogeneration in vivo.	Alginates	249-257	serpin family F member 1	Homo sapiens	31-64
26424392-4	2018	OBJECTIVE: We demonstrate that pigment epithelium-derived factor (PEDF), one such factor that is known to be potent against angiogenesis, promotes osteoblastogenesis in mesenchymal stem cells in vitro, but does not need co-encapsulation of cells in alginate bead scaffolds for osteogeneration in vivo.	Alginates	249-257	serpin family F member 1	Homo sapiens	66-70
28535085-5	2018	We have developed and characterised different alginate-poly-l-lysine-alginate (APA) microcapsules loaded with the insulin producing 1.1B4 cell line.	Alginates	46-54	insulin	Homo sapiens	114-121
28525313-8	2018	Importantly, the treatment of alginate bead cultures with IHH or thyroxine resulted in formation of a discrete domain of hypertrophic cells that mimics tissue architecture of native growth plate cartilage.	Alginates	30-38	Indian hedgehog signaling molecule	Homo sapiens	58-61
29076281-3	2017	PDLSCs and GMSCs are encapsulated in a 3D scaffold based on alginate and hyaluronic acid hydrogels capable of sustained release of human nerve growth factor (NGF).	Alginates	60-68	nerve growth factor	Homo sapiens	137-156
29028608-0	2017	Establishment of nerve growth factor gradients on aligned chitosan-polylactide /alginate fibers for neural tissue engineering applications.	Alginates	80-88	nerve growth factor	Rattus norvegicus	17-36
29028608-6	2017	The diameter of resulting NGF-loaded CH-PLA/alginate fibers was well controlled within a range between 60 and 120mum.	Alginates	44-52	nerve growth factor	Rattus norvegicus	26-29
29028608-7	2017	Calcium ion crosslinked alginate coating layers on fibers showed abilities to administer the sustainable NGF release in a gradient distribution manner for at least 5 weeks.	Alginates	24-32	nerve growth factor	Rattus norvegicus	105-108
28739412-4	2017	Moreover, alginate increased Toll-like receptor 4 (TLR4) expression and activated the Akt/nuclear factor-kappaB (NF-kappaB) and p38 mitogen-activated protein kinase (MAPK) signalling pathways.	Alginates	10-18	toll-like receptor 4	Mus musculus	29-49
28739412-4	2017	Moreover, alginate increased Toll-like receptor 4 (TLR4) expression and activated the Akt/nuclear factor-kappaB (NF-kappaB) and p38 mitogen-activated protein kinase (MAPK) signalling pathways.	Alginates	10-18	toll-like receptor 4	Mus musculus	51-55
28739412-4	2017	Moreover, alginate increased Toll-like receptor 4 (TLR4) expression and activated the Akt/nuclear factor-kappaB (NF-kappaB) and p38 mitogen-activated protein kinase (MAPK) signalling pathways.	Alginates	10-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	86-111
28739412-4	2017	Moreover, alginate increased Toll-like receptor 4 (TLR4) expression and activated the Akt/nuclear factor-kappaB (NF-kappaB) and p38 mitogen-activated protein kinase (MAPK) signalling pathways.	Alginates	10-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	113-122
28739412-4	2017	Moreover, alginate increased Toll-like receptor 4 (TLR4) expression and activated the Akt/nuclear factor-kappaB (NF-kappaB) and p38 mitogen-activated protein kinase (MAPK) signalling pathways.	Alginates	10-18	mitogen-activated protein kinase 14	Mus musculus	128-131
28739412-5	2017	Alginate-promoted phagocytosis was suppressed by the addition of inhibitors of TLR4, NF-kappaB and p38 MAPK and by TLR4 gene knockdown, indicating the involvement of these key components.	Alginates	0-8	toll-like receptor 4	Mus musculus	79-83
28739412-5	2017	Alginate-promoted phagocytosis was suppressed by the addition of inhibitors of TLR4, NF-kappaB and p38 MAPK and by TLR4 gene knockdown, indicating the involvement of these key components.	Alginates	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	85-94
28941182-1	2017	Alginate is a natural rich anionic polysaccharide (APS), commonly available as calcium alginate (CAPS).	Alginates	0-8	calcium dependent secretion activator	Rattus norvegicus	97-101
28941182-1	2017	Alginate is a natural rich anionic polysaccharide (APS), commonly available as calcium alginate (CAPS).	Alginates	79-95	calcium dependent secretion activator	Rattus norvegicus	97-101
28739412-5	2017	Alginate-promoted phagocytosis was suppressed by the addition of inhibitors of TLR4, NF-kappaB and p38 MAPK and by TLR4 gene knockdown, indicating the involvement of these key components.	Alginates	0-8	mitogen-activated protein kinase 14	Mus musculus	99-107
28739412-5	2017	Alginate-promoted phagocytosis was suppressed by the addition of inhibitors of TLR4, NF-kappaB and p38 MAPK and by TLR4 gene knockdown, indicating the involvement of these key components.	Alginates	0-8	toll-like receptor 4	Mus musculus	115-119
28739412-6	2017	This work is the first to propose that alginate promotes phagocytosis via upregulating TLR4 expression and stimulating the Akt/NF-kappaB and p38 MAPK signalling pathways, which may contribute to the capacity of alginate to activate macrophages.	Alginates	39-47	toll-like receptor 4	Mus musculus	87-91
28739412-6	2017	This work is the first to propose that alginate promotes phagocytosis via upregulating TLR4 expression and stimulating the Akt/NF-kappaB and p38 MAPK signalling pathways, which may contribute to the capacity of alginate to activate macrophages.	Alginates	39-47	thymoma viral proto-oncogene 1	Mus musculus	123-126
28739412-6	2017	This work is the first to propose that alginate promotes phagocytosis via upregulating TLR4 expression and stimulating the Akt/NF-kappaB and p38 MAPK signalling pathways, which may contribute to the capacity of alginate to activate macrophages.	Alginates	39-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	127-136
28739412-6	2017	This work is the first to propose that alginate promotes phagocytosis via upregulating TLR4 expression and stimulating the Akt/NF-kappaB and p38 MAPK signalling pathways, which may contribute to the capacity of alginate to activate macrophages.	Alginates	39-47	mitogen-activated protein kinase 14	Mus musculus	141-144
28739412-6	2017	This work is the first to propose that alginate promotes phagocytosis via upregulating TLR4 expression and stimulating the Akt/NF-kappaB and p38 MAPK signalling pathways, which may contribute to the capacity of alginate to activate macrophages.	Alginates	211-219	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	127-136
28739412-6	2017	This work is the first to propose that alginate promotes phagocytosis via upregulating TLR4 expression and stimulating the Akt/NF-kappaB and p38 MAPK signalling pathways, which may contribute to the capacity of alginate to activate macrophages.	Alginates	211-219	mitogen-activated protein kinase 14	Mus musculus	141-144
29200854-0	2017	Oligosaccharide nanomedicine of alginate sodium improves therapeutic results of posterior lumbar interbody fusion with cages for degenerative lumbar disease in osteoporosis patients by downregulating serum miR-155.	Alginates	32-47	microRNA 155	Homo sapiens	206-213
29037116-5	2017	Bovine serum albumin (BSA) was used as a model drug and entrapped in the alginate-HMP beads.	Alginates	73-81	albumin	Homo sapiens	7-20
28537482-0	2017	* Programmed Platelet-Derived Growth Factor-BB and Bone Morphogenetic Protein-2 Delivery from a Hybrid Calcium Phosphate/Alginate Scaffold.	Alginates	121-129	bone morphogenetic protein 2	Homo sapiens	51-79
28537482-7	2017	PDGF and BMP-2 were sequentially released from this hybrid calcium phosphate/alginate scaffold with the desired 3-day overlap in PDGF to BMP-2 delivery.	Alginates	77-85	bone morphogenetic protein 2	Homo sapiens	9-14
28537482-7	2017	PDGF and BMP-2 were sequentially released from this hybrid calcium phosphate/alginate scaffold with the desired 3-day overlap in PDGF to BMP-2 delivery.	Alginates	77-85	bone morphogenetic protein 2	Homo sapiens	137-142
28639378-9	2017	Interestingly, after two weeks of osteo-differentiation, hBMMSCs and GMSCs encapsulated in alginate/GelMA hydrogels still expressed CD146, an MSC surface marker, while MSCs encapsulated in alginate hydrogel failed to express any positive staining.	Alginates	91-99	melanoma cell adhesion molecule	Homo sapiens	132-137
29379633-0	2018	In vitro and in vivo anticandidal activities of alginate-enclosed chitosan-calcium phosphate-loaded Fe-bovine lactoferrin nanocapsules.	Alginates	48-56	lactotransferrin	Bos taurus	110-121
28882369-2	2017	The aim of our study is to fabricate a vascular endothelial growth factor (VEGF)-loaded gelatin/alginate/beta-TCP composite scaffold by 3D printing method using a computer-assisted design (CAD) model.	Alginates	96-104	vascular endothelial growth factor A	Homo sapiens	39-73
28882369-2	2017	The aim of our study is to fabricate a vascular endothelial growth factor (VEGF)-loaded gelatin/alginate/beta-TCP composite scaffold by 3D printing method using a computer-assisted design (CAD) model.	Alginates	96-104	vascular endothelial growth factor A	Homo sapiens	75-79
28882369-3	2017	METHODS: The paste, composed of (VEGF-loaded PLGA)-containing gelatin/alginate/beta-TCP in water, was loaded into standard Nordson cartridges and promptly employed for printing the scaffolds.	Alginates	70-78	vascular endothelial growth factor A	Homo sapiens	33-37
28882369-10	2017	SIGNIFICANCE: The 3D printed gelatin/alginate/beta-TCP scaffold with slow releasing of VEGF can be considered as a potential candidate for regeneration of craniofacial defects.	Alginates	37-45	vascular endothelial growth factor A	Homo sapiens	87-91
30023539-4	2017	Alginate (Alg)-based microreactors loaded with catalase are assembled by droplet microfluidics, and their activity is confirmed.	Alginates	0-8	catalase	Homo sapiens	47-55
28472685-1	2017	The feasibility of adsorption and desorption behavior of nanochitosan(NCS)/sodium alginate(SA)/microcrystalline cellulose (MC) bead prepared in 2:8:1 ratio for Pb(II) removal has been investigated through batch studies.	Alginates	75-90	submaxillary gland androgen regulated protein 3B	Homo sapiens	160-166
28895290-4	2017	Structural characterization shows that the fibrin/alginate matrix is intact after the addition of the Sil membrane.	Alginates	50-58	STIL centriolar assembly protein	Homo sapiens	102-105
28895290-5	2017	By adding a Sil membrane to the original fibrin/alginate scaffold, the resulting two-component scaffolds have a significantly higher shear or storage modulus G".	Alginates	48-56	STIL centriolar assembly protein	Homo sapiens	12-15
28601648-0	2017	Sequential IGF-1 and BMP-6 releasing chitosan/alginate/PLGA hybrid scaffolds for periodontal regeneration.	Alginates	46-54	bone morphogenetic protein 6	Homo sapiens	21-26
28601648-5	2017	Alginate and poly (lactic-co-glycolic acid) (PLGA) microparticles provided release of IGF-1 and BMP-6 for early short period and for long period, respectively.	Alginates	0-8	insulin like growth factor 1	Homo sapiens	86-91
28601648-5	2017	Alginate and poly (lactic-co-glycolic acid) (PLGA) microparticles provided release of IGF-1 and BMP-6 for early short period and for long period, respectively.	Alginates	0-8	bone morphogenetic protein 6	Homo sapiens	96-101
28601648-6	2017	The cell culture studies showed that, chitosan/alginate/PLGA hybrid scaffolds induced proliferation and osteoblastic differentiation of cementoblasts when compared with IGF-1 and BMP-6 free chitosan scaffold.	Alginates	47-55	insulin like growth factor 1	Homo sapiens	169-174
28601648-6	2017	The cell culture studies showed that, chitosan/alginate/PLGA hybrid scaffolds induced proliferation and osteoblastic differentiation of cementoblasts when compared with IGF-1 and BMP-6 free chitosan scaffold.	Alginates	47-55	bone morphogenetic protein 6	Homo sapiens	179-184
28127888-0	2017	Insulin delivery to the brain using intracranial implantation of alginate-encapsulated pancreatic islets.	Alginates	65-73	insulin	Homo sapiens	0-7
28127888-5	2017	In this study, we show that intracranial implantation of 50 pancreatic islets encapsulated in disc-shaped alginate is sufficient to elevate insulin content in the rat brain.	Alginates	106-114	insulin	Homo sapiens	140-147
28127888-9	2017	In conclusion, the intracranial implantation of a small amount of alginate-encapsulated islets is an efficient tool for metabolically regulated insulin delivery to the brain.	Alginates	66-74	insulin	Homo sapiens	144-151
28448789-4	2017	Blastocysts encapsulated within alginate hydrogels supplemented with SPP1 or conjugated with RGD had increased survival compared with non-encapsulated control blastocysts.	Alginates	32-40	secreted phosphoprotein 1	Homo sapiens	69-73
30023539-4	2017	Alginate (Alg)-based microreactors loaded with catalase are assembled by droplet microfluidics, and their activity is confirmed.	Alginates	0-3	catalase	Homo sapiens	47-55
28768895-3	2017	However, detection of p16Ink4a/SAbetaG-positive macrophages in the adipose tissue of old mice and in the peritoneal cavity of young animals following injection of alginate-encapsulated SCs has raised concerns about the exclusivity of these markers for SCs.	Alginates	163-171	cyclin dependent kinase inhibitor 2A	Mus musculus	22-30
28732901-2	2017	In this study, we demonstrated the synthesis of dextran sulfate-doxorubicin (DS-DOX) and alginate-cisplatin (AL-CIS) polymer-drug complexes to produce a transferrin ligand-conjugated liposome.	Alginates	89-97	transferrin	Homo sapiens	153-164
28735026-0	2017	Regulated viral BDNF delivery in combination with Schwann cells promotes axonal regeneration through capillary alginate hydrogels after spinal cord injury.	Alginates	111-119	brain derived neurotrophic factor	Homo sapiens	16-20
28583763-10	2017	The inflammatory cytokine interleukin-1 beta was present in the medium and alginate associated matrix.	Alginates	75-83	interleukin 1 beta	Homo sapiens	26-44
29143781-5	2017	The bioactivity of the proposed implants was enhanced by introducing a hydroxyapatite material and a biologically active agent, namely, growth factor IGF1, encapsulated in calcium alginate microspheres.	Alginates	172-188	insulin-like growth factor I	Oryctolagus cuniculus	150-154
29285239-6	2017	Meanwhile, in order to improve the release properties of LDL-RSG complexes, we structured slow release system of LDL-RSG/chitosan-calcium alginate - nanoparticles (CSNP), which effectively inhibited TGF-beta1-induced HTFs proliferation, synthesis of extracellular matrix and activation of TGF-beta1/SMAD pathway.	Alginates	130-146	transforming growth factor beta 1	Homo sapiens	199-208
29285239-6	2017	Meanwhile, in order to improve the release properties of LDL-RSG complexes, we structured slow release system of LDL-RSG/chitosan-calcium alginate - nanoparticles (CSNP), which effectively inhibited TGF-beta1-induced HTFs proliferation, synthesis of extracellular matrix and activation of TGF-beta1/SMAD pathway.	Alginates	130-146	transforming growth factor beta 1	Homo sapiens	289-298
28989129-0	2017	Assessment of Influence of Contact Time between Alginate and Type III Dental Stone on Properties of Cast Model: An in vitro Study.	Alginates	48-56	calpastatin	Homo sapiens	100-104
28704904-3	2017	This research involved the development of a Spirulina extract-impregnated alginate nanofiber cosmetic patch supported by a polycaprolactone (PCL) nanofiber cover (Spi/Alg-PCL NF patch).	Alginates	74-82	chromogranin A	Homo sapiens	44-47
28711686-6	2017	Our in vivo data show that alginate hydrogels with smaller pores and higher elasticity could prevent pro-inflammatory cytokine-induced MSC apoptosis by down-regulating the Caspase-3- and 8- associated proapoptotic cascades, leading to higher amounts of ectopic bone regeneration.	Alginates	27-35	caspase 3	Homo sapiens	172-188
28711686-10	2017	Alginate hydrogels with smaller pores and higher elasticity prevent pro-inflammatory cytokine-induced MSC apoptosis by down-regulating the Caspase-3- and 8- associated proapoptotic cascade, leading to higher amounts of ectopic bone regeneration.	Alginates	0-8	caspase 3	Homo sapiens	139-155
28718057-6	2017	Conditions for preparing SA-S13E were optimized, and best results were obtained at a sodium alginate concentration of 35 g/L, calcium chloride of 20 g/L, and crude enzyme dosage of 3 mL.	Alginates	85-100	ribosomal protein S13	Homo sapiens	25-32
28643827-7	2017	We also studied the effect of sulfated alginate on the ability of IL-1beta to stimulate inflammatory genes in human chondrocytes and found decreased expression of the pro-inflammatory markers IL-6 and CXCL8, which inversely correlated with the sulfation degree.	Alginates	39-47	interleukin 1 beta	Homo sapiens	66-74
28643827-7	2017	We also studied the effect of sulfated alginate on the ability of IL-1beta to stimulate inflammatory genes in human chondrocytes and found decreased expression of the pro-inflammatory markers IL-6 and CXCL8, which inversely correlated with the sulfation degree.	Alginates	39-47	interleukin 6	Homo sapiens	192-196
28643827-7	2017	We also studied the effect of sulfated alginate on the ability of IL-1beta to stimulate inflammatory genes in human chondrocytes and found decreased expression of the pro-inflammatory markers IL-6 and CXCL8, which inversely correlated with the sulfation degree.	Alginates	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	201-206
28643827-8	2017	Moreover, in studies testing the ability of the alginates to modulate macrophage polarization, we found that they decreased both the gene expression and synthesis of the proinflammatory cytokine TNF-alpha in human THP-1 macrophages with M1-like phenotype in a sulfation-dependent manner.	Alginates	48-57	tumor necrosis factor	Homo sapiens	195-204
28643827-8	2017	Moreover, in studies testing the ability of the alginates to modulate macrophage polarization, we found that they decreased both the gene expression and synthesis of the proinflammatory cytokine TNF-alpha in human THP-1 macrophages with M1-like phenotype in a sulfation-dependent manner.	Alginates	48-57	GLI family zinc finger 2	Homo sapiens	214-219
28768895-7	2017	Moreover, interferon-inducing agent Poly(I:C) dramatically reduced p16Ink4a expression in vivo in our alginate bead model and in the adipose tissue of aged mice.	Alginates	102-110	cyclin dependent kinase inhibitor 2A	Mus musculus	67-75
27322626-2	2017	In this study, alginate encapsulated nanoceramic carriers were designed to deliver acid labile antioxidant enzyme catalase orally.	Alginates	15-23	catalase	Homo sapiens	114-122
28640588-2	2017	Here we show that a complex of salmon calcitonin and oxidized calcium alginate (sCT-OCA) was prepared and loaded into a thermosensitive copolymer hydrogel for long-term antiosteopenia treatment.	Alginates	62-78	secretin	Rattus norvegicus	80-83
28363651-6	2017	Alcalase assistant alginate stimulated RAW264.7 cells to release nitric oxide and inflammatory cytokines TNF-alpha, IL-1, IL-6, IL-10 and IL-12.	Alginates	19-27	tumor necrosis factor	Mus musculus	105-114
28363651-6	2017	Alcalase assistant alginate stimulated RAW264.7 cells to release nitric oxide and inflammatory cytokines TNF-alpha, IL-1, IL-6, IL-10 and IL-12.	Alginates	19-27	interleukin 1 complex	Mus musculus	116-120
28363651-6	2017	Alcalase assistant alginate stimulated RAW264.7 cells to release nitric oxide and inflammatory cytokines TNF-alpha, IL-1, IL-6, IL-10 and IL-12.	Alginates	19-27	interleukin 6	Mus musculus	122-126
28363651-6	2017	Alcalase assistant alginate stimulated RAW264.7 cells to release nitric oxide and inflammatory cytokines TNF-alpha, IL-1, IL-6, IL-10 and IL-12.	Alginates	19-27	interleukin 10	Mus musculus	128-133
28316275-8	2017	While alginate and hyaluronic acid are able to reduce the initial burst and prolong the release of VEGF, the addition of heparin led to a much stronger retention that resulted in an almost linear release over 28 days.	Alginates	6-14	vascular endothelial growth factor A	Homo sapiens	99-103
28723974-0	2017	Alginate hydrogels allow for bioactive and sustained release of VEGF-C and VEGF-D for lymphangiogenic therapeutic applications.	Alginates	0-8	vascular endothelial growth factor C	Gallus gallus	64-70
28723974-0	2017	Alginate hydrogels allow for bioactive and sustained release of VEGF-C and VEGF-D for lymphangiogenic therapeutic applications.	Alginates	0-8	vascular endothelial growth factor A	Gallus gallus	64-68
28723974-4	2017	Injectable alginate hydrogels have been useful for the controlled delivery of many angiogenic factors, including VEGF-A, to stimulate new blood vasculature.	Alginates	11-19	vascular endothelial growth factor A	Gallus gallus	113-119
28723974-6	2017	Thus, the objective of this study was to utilize ionically cross-linked alginate hydrogels to deliver VEGF-C and VEGF-D for potential lymphangiogenic applications.	Alginates	72-80	vascular endothelial growth factor C	Gallus gallus	102-108
28723974-6	2017	Thus, the objective of this study was to utilize ionically cross-linked alginate hydrogels to deliver VEGF-C and VEGF-D for potential lymphangiogenic applications.	Alginates	72-80	vascular endothelial growth factor A	Gallus gallus	102-106
28723974-8	2017	The greatest LEC mitogenic and sprouting response was observed for constant concentrations of VEGF-C and a high initial concentration that gradually decreased over time for VEGF-D. Additionally, alginate hydrogels provided sustained release of radiolabeled VEGF-C and VEGF-D.	Alginates	195-203	vascular endothelial growth factor C	Gallus gallus	94-100
28723974-8	2017	The greatest LEC mitogenic and sprouting response was observed for constant concentrations of VEGF-C and a high initial concentration that gradually decreased over time for VEGF-D. Additionally, alginate hydrogels provided sustained release of radiolabeled VEGF-C and VEGF-D.	Alginates	195-203	vascular endothelial growth factor A	Gallus gallus	94-98
28723974-8	2017	The greatest LEC mitogenic and sprouting response was observed for constant concentrations of VEGF-C and a high initial concentration that gradually decreased over time for VEGF-D. Additionally, alginate hydrogels provided sustained release of radiolabeled VEGF-C and VEGF-D.	Alginates	195-203	vascular endothelial growth factor C	Gallus gallus	257-263
28723974-8	2017	The greatest LEC mitogenic and sprouting response was observed for constant concentrations of VEGF-C and a high initial concentration that gradually decreased over time for VEGF-D. Additionally, alginate hydrogels provided sustained release of radiolabeled VEGF-C and VEGF-D.	Alginates	195-203	vascular endothelial growth factor A	Gallus gallus	173-177
28723974-10	2017	Overall, these findings demonstrate that alginate hydrogels can provide sustained and bioactive release of VEGF-C and VEGF-D which could have applications for therapeutic lymphangiogenesis.	Alginates	41-49	vascular endothelial growth factor C	Gallus gallus	107-113
28723974-10	2017	Overall, these findings demonstrate that alginate hydrogels can provide sustained and bioactive release of VEGF-C and VEGF-D which could have applications for therapeutic lymphangiogenesis.	Alginates	41-49	vascular endothelial growth factor A	Gallus gallus	107-111
28432956-6	2017	LRP5-alginate gels successfully induced stem cell aggregation and enhanced chondrogenic differentiation of D1 stem cells, compared to RGD-alginate gels, at low cell density.	Alginates	5-13	low density lipoprotein receptor-related protein 5	Mus musculus	0-4
28143741-8	2017	Oral administration of HA-KPV-NPs encapsulated in a hydrogel (chitosan/alginate) exhibited a much stronger capacity to prevent mucosa damage and downregulate TNF-alpha, thus they showed a much better therapeutic efficacy against UC in a mouse model, compared with a KPV-NP/hydrogel system.	Alginates	71-79	tumor necrosis factor	Mus musculus	158-167
28482498-2	2017	Due to the naturally abundant carboxyl groups, the prepared alginate gel beads exhibited a relatively superior integrated adsorption performance toward lysozyme, including a superior adsorption capacity of 213mgg-1, fast adsorption equilibrium within 12h, good selectivity, and good reversibility.	Alginates	60-68	lysozyme	Homo sapiens	152-160
28432956-0	2017	Introduction of N-cadherin-binding motif to alginate hydrogels for controlled stem cell differentiation.	Alginates	44-52	cadherin 2	Mus musculus	16-26
28432956-4	2017	In this study, alginate hydrogels were modified with a peptide derived from the low-density lipoprotein receptor-related protein 5 (LRP5), which is known to bind to N-cadherin, as a cell-cell interaction motif.	Alginates	15-23	low density lipoprotein receptor-related protein 5	Mus musculus	80-130
28432956-4	2017	In this study, alginate hydrogels were modified with a peptide derived from the low-density lipoprotein receptor-related protein 5 (LRP5), which is known to bind to N-cadherin, as a cell-cell interaction motif.	Alginates	15-23	low density lipoprotein receptor-related protein 5	Mus musculus	132-136
28432956-4	2017	In this study, alginate hydrogels were modified with a peptide derived from the low-density lipoprotein receptor-related protein 5 (LRP5), which is known to bind to N-cadherin, as a cell-cell interaction motif.	Alginates	15-23	cadherin 2	Mus musculus	165-175
28432956-5	2017	In vitro changes in the morphology and differentiation of mouse bone marrow stromal cells (D1 stem cells) cultured in LRP5-alginate hydrogels were investigated.	Alginates	123-131	low density lipoprotein receptor-related protein 5	Mus musculus	118-122
28482594-4	2017	NGF released from alginate (Alg) microspheres on SF scaffold (SF/Alg composites scaffolds) to the central lesion site of SCI significantly enhanced the sparing of spinal cord tissue and increased the number of surviving neurons.	Alginates	18-26	nerve growth factor	Homo sapiens	0-3
28482594-4	2017	NGF released from alginate (Alg) microspheres on SF scaffold (SF/Alg composites scaffolds) to the central lesion site of SCI significantly enhanced the sparing of spinal cord tissue and increased the number of surviving neurons.	Alginates	28-31	nerve growth factor	Homo sapiens	0-3
28482529-0	2017	Composite membranes of alginate and chitosan reinforced with cotton or linen fibers incorporating epidermal growth factor.	Alginates	23-31	epidermal growth factor	Homo sapiens	98-121
28301717-0	2017	Glucose-Triggered Insulin Release from Fe3+ -Cross-linked Alginate Hydrogel: Experimental Study and Theoretical Modeling.	Alginates	58-66	insulin	Homo sapiens	18-25
28536312-0	2017	Effects of ginsenoside Rg1-loaded alginate-chitosan microspheres on human bone marrow stromal cells.	Alginates	34-42	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	23-26
28536312-3	2017	The present study was to prepare Rg1-loaded alginate-chitosan microspheres and research the effects of microspheres on human bone marrow (BM) stromal cells (hBMSC).	Alginates	44-52	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	33-36
28301717-1	2017	We study the mechanisms involved in the release, triggered by the application of glucose, of insulin entrapped in Fe3+ -cross-linked alginate hydrogel particles further stabilized with a polyelectrolyte.	Alginates	133-141	insulin	Homo sapiens	93-100
32264148-0	2017	Gum tragacanth-alginate beads as proangiogenic-osteogenic cell encapsulation systems for bone tissue engineering.	Alginates	15-23	OTU deubiquitinase with linear linkage specificity	Homo sapiens	0-3
28772991-0	2017	Extractant Immobilization in Alginate Capsules (Matrix- and Mononuclear-Type): Application to Pb(II) Sorption from HCl Solutions.	Alginates	29-37	submaxillary gland androgen regulated protein 3B	Homo sapiens	94-100
32264148-2	2017	Here, we hypothesize that the use of gum tragacanth (GT) with alginate might improve the biological properties of calcium alginate (CA) beads, a common cell encapsulation system.	Alginates	62-70	OTU deubiquitinase with linear linkage specificity	Homo sapiens	37-40
32264148-2	2017	Here, we hypothesize that the use of gum tragacanth (GT) with alginate might improve the biological properties of calcium alginate (CA) beads, a common cell encapsulation system.	Alginates	114-130	OTU deubiquitinase with linear linkage specificity	Homo sapiens	37-40
28266351-8	2017	Oxidized alginate-gelatin crosslinked hydrogel was used to immobilize osteoblastic (ST2) and osteoclastic (RAW) progenitor cells.	Alginates	9-17	ST2	Homo sapiens	84-87
27469285-6	2017	Lin28a and Sall4 genes were significantly upregulated after cryopreservation in alginate hydrogel.	Alginates	80-88	lin-28 homolog A	Mus musculus	0-6
27469285-6	2017	Lin28a and Sall4 genes were significantly upregulated after cryopreservation in alginate hydrogel.	Alginates	80-88	spalt like transcription factor 4	Mus musculus	11-16
28261854-1	2017	The goal of this study was to determine whether the guluronate (G) rich alginate OligoG CF-5/20 (OligoG) could detach cystic fibrosis (CF) mucus by calcium chelation, which is also required for normal mucin unfolding.	Alginates	72-80	coagulation factor V	Mus musculus	88-95
28469183-4	2017	Results showed that tumor-stroma cells interacted with each other and fused, the transcription of RFP was higher than that of 2D culture model and control group with cells mixed directly into alginate, respectively.	Alginates	192-200	tripartite motif containing 27	Homo sapiens	98-101
28490734-0	2017	Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages.	Alginates	70-78	toll-like receptor 4	Mus musculus	33-37
28490734-1	2017	Alginate, a natural acidic polysaccharide extracted from marine brown seaweeds, is composed of different blocks of beta-(1, 4)-D-mannuronate (M) and its C-5 epimer alpha-(1, 4)-L-guluronate (G).	Alginates	0-8	hemoglobin, beta adult major chain	Mus musculus	115-125
28189990-1	2017	The binary sorption of Pb(II) and Cu(II) onto calcium alginate, algal biomass and algal/glutaraldehyde-crosslinked polyethyleneimine (PEI) composite beads was studied in the absence and presence of Ca(II).	Alginates	46-62	submaxillary gland androgen regulated protein 3B	Homo sapiens	23-40
28450696-0	2017	Alginate Particles with Ovalbumin (OVA) Peptide Can Serve as a Carrier and Adjuvant for Immune Therapy in B16-OVA Cancer Model.	Alginates	0-8	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	24-33
28284103-7	2017	We first developed VEGF-encapsulated MSCs using self-assembled gelatin and alginate polyelectrolytes to improve angiogenesis and cardiac function.	Alginates	75-83	vascular endothelial growth factor A	Homo sapiens	19-23
26118827-0	2017	Acceleration of skin regeneration in full-thickness burns by incorporation of bFGF-loaded alginate microspheres into a CMCS-PVA hydrogel.	Alginates	90-98	fibroblast growth factor 2	Rattus norvegicus	78-82
26118827-4	2017	To this end, bFGF-loaded alginate microspheres (Ms) were fabricated and incorporated into carboxymethyl chitosan (CMCS)-poly(vinyl alcohol) (PVA) to form a composite hydrogel.	Alginates	25-33	fibroblast growth factor 2	Rattus norvegicus	13-17
28327716-3	2017	Biocompatible alginate/chitosan polyelectrolyte multilayers (PEM) were assembled on the M-MSNs to achieve a pH-responsive drug delivery system and adsorb P-gp shRNA for reversing the multidrug resistance.	Alginates	14-22	phosphoglycolate phosphatase	Mus musculus	154-158
28656080-3	2017	Alginate lyase gene (algl) is a member of alginate producing operon which by glycosidase activity produces primer for other enzymes in this cluster.	Alginates	42-50	alginate lyase	Pseudomonas aeruginosa PAO1	0-14
28541940-0	2017	Efficient removal of Cd2+ ion from water by calcium alginate hydrogel filtration membrane.	Alginates	44-60	CD2 molecule	Homo sapiens	21-24
28450696-0	2017	Alginate Particles with Ovalbumin (OVA) Peptide Can Serve as a Carrier and Adjuvant for Immune Therapy in B16-OVA Cancer Model.	Alginates	0-8	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	35-38
28450696-4	2017	Alginate particles loaded with OVA peptide were produced via emulsion.	Alginates	0-8	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	31-34
28185909-7	2017	We grafted the IGF-I binding peptide sequence from IGFBP-5 onto alginate in order to retain the endogenous IGF-I produced by transfected chondrocytes.	Alginates	64-72	insulin like growth factor 1	Homo sapiens	15-20
28185909-7	2017	We grafted the IGF-I binding peptide sequence from IGFBP-5 onto alginate in order to retain the endogenous IGF-I produced by transfected chondrocytes.	Alginates	64-72	insulin like growth factor 1	Homo sapiens	107-112
28185909-13	2017	This approach enabled tuning of binding of IGF-I to alginate, which increased GAG and HYPRO production by transfected chondrocytes.	Alginates	52-60	insulin like growth factor 1	Homo sapiens	43-48
28107756-5	2017	The experimental data for adsorption of Cs(I) ions from aqueous solution with the initial concentrations of 50, 100 and 200 mg L-1 on the surface of combined maghemite-titania PVA-alginate beads were well fit by the pseudo-second-order and Langmuir models.	Alginates	180-188	immunoglobulin kappa variable 1-16	Homo sapiens	127-130
28258142-3	2017	To shed light on the c-di-GMP-mediated activation of alginate polymerization in vivo, an in silico structural model of Alg8 fused to the c-di-GMP binding PilZ domain informed by the structure of cellulose synthase, BcsA, was developed.	Alginates	53-61	ALG8 alpha-1,3-glucosyltransferase	Homo sapiens	119-123
28258142-7	2017	Alg8 variants responded differently to various c-di-GMP levels, while MucR imparted c-di-GMP for activation of alginate polymerase.	Alginates	111-119	ALG8 alpha-1,3-glucosyltransferase	Homo sapiens	0-4
28258142-11	2017	The production of alginate is mediated by interacting membrane proteins Alg8 and Alg44, while their activity is posttranslationally regulated by the second messenger c-di-GMP, a well-known regulator of the synthesis of a range of other exopolysaccharides in bacteria.	Alginates	18-26	ALG8 alpha-1,3-glucosyltransferase	Homo sapiens	72-76
28258142-13	2017	Experimental evidence that the activation of alginate polymerization requires the engagement of specific amino acid residues residing at the catalytic domain of Alg8 glycosyltransferase was obtained, and these residues are proposed to exert an allosteric effect on the PilZAlg44 domain upon c-di-GMP binding.	Alginates	45-53	ALG8 alpha-1,3-glucosyltransferase	Homo sapiens	161-165
27270338-6	2017	Immunohistochemical analysis revealed that the nine fully treated rats had venous sinus-like structures and quantitative reverse transcription polymerase chain reaction analysis of extracts from their alginate gel sponge sheets revealed that the amounts of mRNA encoding the nerve growth factor (NGF), and vascular endothelial growth factor (VEGF) were significantly higher than those for rats treated with alginate gel sheets without cell supplementation (NGF: P = 0.0309; VEGF: P &lt; 0.0001).	Alginates	201-209	nerve growth factor	Rattus norvegicus	275-294
27987420-8	2017	Compared to the free cells, the bacteria encapsulated chitosan/alginate bio-microcapsules produced 1-6 times higher PYR biodegradation rates at a high initial PYR concentration (50mgL-1) and extremely low pH values (pH =3) or temperatures (10 C or 40 C), as well as high salt stress.	Alginates	63-71	LLGL scribble cell polarity complex component 1	Homo sapiens	180-185
25783558-0	2017	Controlled release of vascular endothelial growth factor from spray-dried alginate microparticles in collagen-hydroxyapatite scaffolds for promoting vascularization and bone repair.	Alginates	74-82	vascular endothelial growth factor A	Rattus norvegicus	22-56
25783558-4	2017	VEGF was initially encapsulated in alginate MPs by spray-drying, producing particles of &lt; 10 microm in diameter.	Alginates	35-43	vascular endothelial growth factor A	Rattus norvegicus	0-4
28361894-0	2017	The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption.	Alginates	33-41	CXXC finger protein 5	Homo sapiens	58-65
26043934-3	2017	Thus, the aim of the present study was to demonstrate the improved biocompatibility of rapamycin-containing polyethylene glycol (Rapa-PEG)-coating on alginate microcapsules containing xenogeneic islets.	Alginates	150-158	transcriptional regulating factor 1	Mus musculus	129-133
26043934-4	2017	The Rapa-PEG-coating on the alginate layer was observed using scanning electron microscopy (SEM) and the molecular cut-off weight of the microcapsules was approximately 70 kDa.	Alginates	28-36	transcriptional regulating factor 1	Mus musculus	4-8
26043934-5	2017	The viabilities of the alginate-encapsulated and Rapa-PEG-coated alginate-encapsulated islets were lower than the viability of the naked islets just after encapsulation, but these the differences diminished over time in culture dishes.	Alginates	65-73	transcriptional regulating factor 1	Mus musculus	49-53
26043934-6	2017	Rapa-PEG-coating on the alginate capsules effectively decreased the proliferation of macrophage cells compared to the non-coating and alginate coating of xenogeneic pancreas tissues.	Alginates	24-32	transcriptional regulating factor 1	Mus musculus	0-4
26043934-6	2017	Rapa-PEG-coating on the alginate capsules effectively decreased the proliferation of macrophage cells compared to the non-coating and alginate coating of xenogeneic pancreas tissues.	Alginates	134-142	transcriptional regulating factor 1	Mus musculus	0-4
26043934-8	2017	The random blood glucose levels of diabetic mice significantly improved following the transplantation of alginate-encapsulated and Rapa-PEG-coated alginate-encapsulated islets, but there were no significant differences between these two groups.	Alginates	147-155	transcriptional regulating factor 1	Mus musculus	131-135
26043934-9	2017	However, there was a significant decrease in the number of microcapsules with fibrotic cell infiltration in the Rapa-PEG-coated alginate microcapsule group compared to the alginate microcapsule group.	Alginates	128-136	transcriptional regulating factor 1	Mus musculus	112-116
26043934-9	2017	However, there was a significant decrease in the number of microcapsules with fibrotic cell infiltration in the Rapa-PEG-coated alginate microcapsule group compared to the alginate microcapsule group.	Alginates	172-180	transcriptional regulating factor 1	Mus musculus	112-116
28118715-0	2017	Hybrid Alginate-Protein-Coated Graphene Oxide Microcapsules Enhance the Functionality of Erythropoietin Secreting C2C12 Myoblasts.	Alginates	7-15	erythropoietin	Homo sapiens	89-103
27270338-6	2017	Immunohistochemical analysis revealed that the nine fully treated rats had venous sinus-like structures and quantitative reverse transcription polymerase chain reaction analysis of extracts from their alginate gel sponge sheets revealed that the amounts of mRNA encoding the nerve growth factor (NGF), and vascular endothelial growth factor (VEGF) were significantly higher than those for rats treated with alginate gel sheets without cell supplementation (NGF: P = 0.0309; VEGF: P &lt; 0.0001).	Alginates	407-415	nerve growth factor	Rattus norvegicus	275-294
27270338-6	2017	Immunohistochemical analysis revealed that the nine fully treated rats had venous sinus-like structures and quantitative reverse transcription polymerase chain reaction analysis of extracts from their alginate gel sponge sheets revealed that the amounts of mRNA encoding the nerve growth factor (NGF), and vascular endothelial growth factor (VEGF) were significantly higher than those for rats treated with alginate gel sheets without cell supplementation (NGF: P = 0.0309; VEGF: P &lt; 0.0001).	Alginates	407-415	nerve growth factor	Rattus norvegicus	296-299
27748553-4	2017	The results here show that BMP4 release from alginate sulfate MPs is significantly retarded by the sulfated groups compared to neat alginate.	Alginates	45-53	bone morphogenetic protein 4	Homo sapiens	27-31
27940197-13	2017	STATEMENT OF SIGNIFICANCE: Alginate hydrogel-based BMP-2 delivery has induced better spatiotemporal bone regeneration in animals, compared to clinically used collagen sponge, at lower BMP-2 doses.	Alginates	27-35	bone morphogenetic protein 2	Rattus norvegicus	51-56
28170076-0	2017	Biomimetic sulphated alginate hydrogels suppress IL-1beta-induced inflammatory responses in human chondrocytes.	Alginates	21-29	interleukin 1 beta	Homo sapiens	49-57
28170076-8	2017	The sulphated alginate matrices were found to interact with IL-1beta, and proposed to inhibit inflammatory induction by sequestering cytokines from their receptors.	Alginates	14-22	interleukin 1 beta	Homo sapiens	60-68
28155851-5	2017	The gel prepared from the mixture of decellularized adipose tissue and high viscous sodium alginate was used to entrap the catalase, and was coated to 3D polycaprolactone porous scaffolds.	Alginates	84-99	catalase	Homo sapiens	123-131
27940197-13	2017	STATEMENT OF SIGNIFICANCE: Alginate hydrogel-based BMP-2 delivery has induced better spatiotemporal bone regeneration in animals, compared to clinically used collagen sponge, at lower BMP-2 doses.	Alginates	27-35	bone morphogenetic protein 2	Rattus norvegicus	184-189
27940197-15	2017	We investigated the potential of the alginate system, with comparatively favorable BMP-2 release-kinetics, to reduce heterotopic ossification and promote bone regeneration, when used with a high BMP-2 dose.	Alginates	37-45	bone morphogenetic protein 2	Rattus norvegicus	83-88
27940197-15	2017	We investigated the potential of the alginate system, with comparatively favorable BMP-2 release-kinetics, to reduce heterotopic ossification and promote bone regeneration, when used with a high BMP-2 dose.	Alginates	37-45	bone morphogenetic protein 2	Rattus norvegicus	195-200
27864849-8	2017	plecoglossicida R-67094 and R. irregularis MUCL 41833 in alginate beads improved root colonization by the AMF and its further life cycle under the experimental conditions.	Alginates	57-65	granule-bound starch synthase 1, chloroplastic/amyloplastic	Solanum tuberosum	106-109
27826002-6	2017	Compared with controls (no gel), 0.5% RGD-alginate increased: the percentage of EBs with pigmented RPE foci; the percentage EBs with optic vesicles (OVs) and pigmented RPE simultaneously; the area covered by RPE; frequency of RPE cells (CRALBP+); expression of RPE markers (TYR and RPE65) and the retinal ganglion cell marker, MATH5.	Alginates	42-50	retinoid isomerohydrolase RPE65	Homo sapiens	282-287
27826002-6	2017	Compared with controls (no gel), 0.5% RGD-alginate increased: the percentage of EBs with pigmented RPE foci; the percentage EBs with optic vesicles (OVs) and pigmented RPE simultaneously; the area covered by RPE; frequency of RPE cells (CRALBP+); expression of RPE markers (TYR and RPE65) and the retinal ganglion cell marker, MATH5.	Alginates	42-50	atonal bHLH transcription factor 7	Homo sapiens	327-332
27864849-9	2017	SIGNIFICANCE AND IMPACT OF THE STUDY: Co-entrapment of suitable AMF-PGPR combinations within alginate beads may represent an innovative technology that can be fine-tuned for the development of efficient consortia-based bioformulations.	Alginates	93-101	granule-bound starch synthase 1, chloroplastic/amyloplastic	Solanum tuberosum	64-67
28053600-0	2017	Alginate-embedded HuH-7 cells increase MMP-9 and reduce OCLN expression in vitro.	Alginates	0-8	MIR7-3 host gene	Homo sapiens	18-23
28053600-0	2017	Alginate-embedded HuH-7 cells increase MMP-9 and reduce OCLN expression in vitro.	Alginates	0-8	matrix metallopeptidase 9	Homo sapiens	39-44
28053600-0	2017	Alginate-embedded HuH-7 cells increase MMP-9 and reduce OCLN expression in vitro.	Alginates	0-8	occludin	Homo sapiens	56-60
28053600-8	2017	METHODS: HuH-7 cells were encapsulated in sodium alginate (three-dimensional model) to be compared with cells grown in two-dimensional flasks.	Alginates	42-57	MIR7-3 host gene	Homo sapiens	9-14
28053600-12	2017	CONCLUSIONS: This work shows the effects of using sodium alginate capsules as a three-dimensional model to the study of HuH-7.	Alginates	50-65	MIR7-3 host gene	Homo sapiens	120-125
27529335-5	2017	Preformed cell aggregates with defined cell numbers in RGD-modified alginate gels retained adequate N-cadherin-mediated cell-cell interactions and increased chondrogenic marker gene expression, compared with the homogeneously dispersed cells in the gels.	Alginates	68-76	cadherin 2	Mus musculus	100-110
29369299-8	2017	We found that despite the absence of locomotor improvement, application of both alginate and MSCs caused significant increase in the number of GAP-43 positive axons.	Alginates	80-88	growth associated protein 43	Rattus norvegicus	143-149
27384939-5	2017	As hydrogel component, alginate and an alginate-gellan gum blend were evaluated; the blend exhibited a more favourable VEGF release profile and was chosen for biphasic scaffold fabrication.	Alginates	39-47	vascular endothelial growth factor A	Rattus norvegicus	119-123
28239398-8	2017	To conclude, nAg alginate was potentially superior to MH and conventional dressing in healing diabetic foot ulcer in terms of ulcer size reduction rate.	Alginates	17-25	NBAS subunit of NRZ tethering complex	Homo sapiens	13-16
27432784-3	2017	The optimization of cell growth and alginate lyase (algL) production was carried out by the addition of 0.8% alginate and 0.2-0.3 M NaCl to the culture medium.	Alginates	36-44	alginate lyase	Pseudomonas aeruginosa PAO1	52-56
27432784-10	2017	TAG8 growth and algL production were augmented with an increase in sodium alginate concentration and also by the addition of 0.2-0.3 M NaCl.	Alginates	67-82	alginate lyase	Pseudomonas aeruginosa PAO1	16-20
27432784-14	2017	CONCLUSION: The identification of novel algL genes from microbial communities constitutes a new approach for exploring lyases with specific activity against bacterial alginates and may thus contribute to the eradication of persistent biofilms from clinical samples.	Alginates	167-176	alginate lyase	Pseudomonas aeruginosa PAO1	40-44
28930755-0	2017	VEGF and IGF Delivered from Alginate Hydrogels Promote Stable Perfusion Recovery in Ischemic Hind Limbs of Aged Mice and Young Rabbits.	Alginates	28-36	vascular endothelial growth factor A	Mus musculus	0-4
28930755-0	2017	VEGF and IGF Delivered from Alginate Hydrogels Promote Stable Perfusion Recovery in Ischemic Hind Limbs of Aged Mice and Young Rabbits.	Alginates	28-36	insulin-like growth factor 1	Mus musculus	9-12
28930755-3	2017	Alginate hydrogels providing sustained release of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF) were injected into ischemic hind limbs in middle-aged and old mice, and also in young rabbits, as a test of the scalability of this local growth factor treatment.	Alginates	0-8	vascular endothelial growth factor A	Mus musculus	50-84
28930755-3	2017	Alginate hydrogels providing sustained release of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF) were injected into ischemic hind limbs in middle-aged and old mice, and also in young rabbits, as a test of the scalability of this local growth factor treatment.	Alginates	0-8	vascular endothelial growth factor A	Mus musculus	86-90
28930755-3	2017	Alginate hydrogels providing sustained release of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF) were injected into ischemic hind limbs in middle-aged and old mice, and also in young rabbits, as a test of the scalability of this local growth factor treatment.	Alginates	0-8	insulin-like growth factor 1	Mus musculus	96-124
28930755-3	2017	Alginate hydrogels providing sustained release of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF) were injected into ischemic hind limbs in middle-aged and old mice, and also in young rabbits, as a test of the scalability of this local growth factor treatment.	Alginates	0-8	insulin-like growth factor 1	Mus musculus	126-129
28930755-5	2017	In rabbits, the delivery of VEGF alone or in combination with IGF from alginate hydrogels, at a dose 2 orders of magnitude lower than the typical doses used in past rabbit studies, enhanced perfusion recovery when given immediately after surgery, or as a treatment for chronic ischemia.	Alginates	71-79	insulin-like growth factor 1	Mus musculus	62-65
28930755-7	2017	These data together suggest that alginate hydrogels providing local delivery of low doses of VEGF and IGF constitute a safe and effective treatment for hind-limb ischemia in clinically relevant animal models, thereby supporting the potential clinical translation of this concept.	Alginates	33-41	vascular endothelial growth factor A	Oryctolagus cuniculus	93-97
28930755-7	2017	These data together suggest that alginate hydrogels providing local delivery of low doses of VEGF and IGF constitute a safe and effective treatment for hind-limb ischemia in clinically relevant animal models, thereby supporting the potential clinical translation of this concept.	Alginates	33-41	insulin-like growth factor 1	Mus musculus	102-105
27738946-1	2017	Transplantation of alginate-encapsulated islets has the potential to treat patients suffering from type I diabetes, a condition characterized by an autoimmune attack against insulin-secreting beta cells.	Alginates	19-27	insulin	Homo sapiens	174-181
29230268-0	2017	An Alginate/Cyclodextrin Spray Drying Matrix to Improve Shelf Life and Antioxidant Efficiency of a Blood Orange By-Product Extract Rich in Polyphenols: MMPs Inhibition and Antiglycation Activity in Dysmetabolic Diseases.	Alginates	3-11	matrix metallopeptidase 2	Homo sapiens	152-156
29230268-5	2017	The good inhibition effect of the dried extract on the AGE formation and the MMP-2 and MMP-9 activity is presumably due to a synergic effect exerted by both anthocyanin and bioflavonoid extract compounds and was improved by the use of alginate and cyclodextrin.	Alginates	235-243	matrix metallopeptidase 2	Homo sapiens	77-82
29230268-5	2017	The good inhibition effect of the dried extract on the AGE formation and the MMP-2 and MMP-9 activity is presumably due to a synergic effect exerted by both anthocyanin and bioflavonoid extract compounds and was improved by the use of alginate and cyclodextrin.	Alginates	235-243	matrix metallopeptidase 9	Homo sapiens	87-92
28197209-8	2017	And also, we selected Arg-Gly-Asp- (RGD-) conjugated alginate hydrogel for BMP-2 delivery because alginate is able to release BMP-2 in a sustained manner and it is a biocompatible material.	Alginates	53-61	bone morphogenetic protein 2	Homo sapiens	75-80
28197209-8	2017	And also, we selected Arg-Gly-Asp- (RGD-) conjugated alginate hydrogel for BMP-2 delivery because alginate is able to release BMP-2 in a sustained manner and it is a biocompatible material.	Alginates	53-61	bone morphogenetic protein 2	Homo sapiens	126-131
28197209-8	2017	And also, we selected Arg-Gly-Asp- (RGD-) conjugated alginate hydrogel for BMP-2 delivery because alginate is able to release BMP-2 in a sustained manner and it is a biocompatible material.	Alginates	98-106	bone morphogenetic protein 2	Homo sapiens	75-80
28197209-8	2017	And also, we selected Arg-Gly-Asp- (RGD-) conjugated alginate hydrogel for BMP-2 delivery because alginate is able to release BMP-2 in a sustained manner and it is a biocompatible material.	Alginates	98-106	bone morphogenetic protein 2	Homo sapiens	126-131
27523029-0	2016	TGF-beta affinity-bound to a macroporous alginate scaffold generates local and peripheral immunotolerant responses and improves allocell transplantation.	Alginates	41-49	transforming growth factor beta 1	Homo sapiens	0-8
27756626-4	2016	Here, we design a zein-alginate based oral drug delivery system that protects SOD from the harsh conditions of gastrointestinal tract and releases it in the environment of the small intestine.	Alginates	23-31	superoxide dismutase 1	Homo sapiens	78-81
27756626-7	2016	ZAN (200:40) at the weight ratio of 200mg zein to 40mg of alginate releases SOD in a pH dependent manner, and it releases 90.8+-1.2% of encapsulated SOD at pH 7.4 in 2h, while only 11.4+-0.4% of SOD was released at pH 1.3.	Alginates	58-66	superoxide dismutase 1	Homo sapiens	76-79
27649310-6	2016	In fouling experiments using tap water containing 50 mg L-1 alginate, a simple backwash could remove the fouling on Alg L immobilized membrane, but not that on the control membrane.	Alginates	60-68	immunoglobulin kappa variable 1-16	Homo sapiens	56-59
27612740-5	2016	In vitro cell differentiation results showed that such an alginate-dopamine gel can promote the osteogenic differentiation of mesenchymal stem cell after PCR and ALP assays.	Alginates	58-66	ATHS	Homo sapiens	162-165
27495851-3	2016	Here amide hydrogen/deuterium exchange (HDX) mass spectrometry was employed to localize insulin dynamics induced by interactions with three natural polysaccharides, i.e. chitosan (CH), sodium alginate (ALG) and chondroitin sulfate (CS).	Alginates	185-200	insulin	Homo sapiens	88-95
27495851-3	2016	Here amide hydrogen/deuterium exchange (HDX) mass spectrometry was employed to localize insulin dynamics induced by interactions with three natural polysaccharides, i.e. chitosan (CH), sodium alginate (ALG) and chondroitin sulfate (CS).	Alginates	202-205	insulin	Homo sapiens	88-95
29158741-7	2017	The stimulation of encapsulated hASC with proinflammatory cytokines resulted in the production of IDO, PGE2, and HGF whose concentration was always higher when cells were encapsulated in Si-HPMC particles than in alginate ones.	Alginates	213-221	indoleamine 2,3-dioxygenase 1	Homo sapiens	98-101
27966930-2	2016	In this study, pancreatic lipase was encapsulated in hydrogel beads fabricated from alginate (gel former), calcium chloride (cross-linker), and magnesium hydroxide (buffer).	Alginates	84-92	pancreatic lipase	Homo sapiens	15-32
32263739-0	2016	Alginate microcapsules co-embedded with MSCs and anti-EGF mAb for the induction of hair cell-like cells in guinea pigs by taking advantage of host EGF.	Alginates	0-8	pro-epidermal growth factor	Cavia porcellus	54-57
27619839-4	2016	METHODS: We combined these approaches and produced a compacted calcium-alginate microsphere patch, restrained by a chitosan sheet, to deliver vascular endothelial growth factor (VEGF) to the heart after myocardial injury in rats.	Alginates	71-79	vascular endothelial growth factor A	Rattus norvegicus	142-176
27619839-4	2016	METHODS: We combined these approaches and produced a compacted calcium-alginate microsphere patch, restrained by a chitosan sheet, to deliver vascular endothelial growth factor (VEGF) to the heart after myocardial injury in rats.	Alginates	71-79	vascular endothelial growth factor A	Rattus norvegicus	178-182
27523029-2	2016	Here, we investigated the feasibility of generating an immunoregulatory environment in a highly vascularized macroporous alginate scaffold by affinity-binding of the transforming growth factor-beta (TGF-beta) in a manner mimicking its binding to heparan sulfate.	Alginates	121-129	transforming growth factor beta 1	Homo sapiens	166-197
27523029-2	2016	Here, we investigated the feasibility of generating an immunoregulatory environment in a highly vascularized macroporous alginate scaffold by affinity-binding of the transforming growth factor-beta (TGF-beta) in a manner mimicking its binding to heparan sulfate.	Alginates	121-129	transforming growth factor beta 1	Homo sapiens	199-207
28460915-0	2016	Properties of lysozyme/sodium alginate complexes for the development of antimicrobial films.	Alginates	23-38	lysozyme	Homo sapiens	14-22
28460915-7	2016	Moreover, lysozyme/sodium alginate complexes were used to manufacture an edible antimicrobial film to target lysozyme sensitive microorganisms.	Alginates	19-34	lysozyme	Homo sapiens	109-117
28460915-1	2016	Complexation study of lysozyme (0.714g/L) by sodium alginate at pH7 showed that aggregates formation was a two-phase process.	Alginates	45-60	lysozyme	Homo sapiens	22-30
28460915-5	2016	Lysozyme enzymatic activity decreased upon complexation with sodium alginate but was fully recovered after calcium chloride addition.	Alginates	61-76	lysozyme	Homo sapiens	0-8
28460915-7	2016	Moreover, lysozyme/sodium alginate complexes were used to manufacture an edible antimicrobial film to target lysozyme sensitive microorganisms.	Alginates	19-34	lysozyme	Homo sapiens	10-18
27481343-2	2016	The adsorption capacity of an activated carbon - calcium alginate composite material (ACAA-Ca) has been tested with the aim of developing a new and more efficient adsorbent material to remove Pb(II) ion from aqueous solution.	Alginates	49-65	submaxillary gland androgen regulated protein 3B	Homo sapiens	192-198
27474590-0	2016	Magnetic field-responsive release of transforming growth factor beta 1 from heparin-modified alginate ferrogels.	Alginates	93-101	transforming growth factor, beta 1	Mus musculus	37-70
27392773-7	2016	The stability of alginate microbeads in SCF was improved with increasing AmCS concentration in the coating medium up to 2%.	Alginates	17-25	KIT ligand	Homo sapiens	40-43
27474590-5	2016	To modulate the release of transforming growth factor beta 1 (TGF-beta1) under magnetic stimulation, alginate was chemically modified with heparin, as TGF-beta1 has a heparin-binding domain.	Alginates	101-109	transforming growth factor, beta 1	Mus musculus	27-60
27508284-0	2016	Encapsulated feeder cells within alginate beads for ex vivo expansion of cord blood-derived CD34(+) cells.	Alginates	33-41	CD34 molecule	Homo sapiens	92-96
27474590-5	2016	To modulate the release of transforming growth factor beta 1 (TGF-beta1) under magnetic stimulation, alginate was chemically modified with heparin, as TGF-beta1 has a heparin-binding domain.	Alginates	101-109	transforming growth factor, beta 1	Mus musculus	62-71
27508284-5	2016	Furthermore, the alginate beads supported CD34(+) cells/hAMSCs 2D indirect co-culture exhibited increased TNCs expansion, higher percentages of CD34(+) and CD34(+)CD38(-) cells, and better cell vitality when compared to the 2D co-culture.	Alginates	17-25	CD34 molecule	Homo sapiens	42-46
27474590-5	2016	To modulate the release of transforming growth factor beta 1 (TGF-beta1) under magnetic stimulation, alginate was chemically modified with heparin, as TGF-beta1 has a heparin-binding domain.	Alginates	101-109	transforming growth factor, beta 1	Mus musculus	151-160
27508284-5	2016	Furthermore, the alginate beads supported CD34(+) cells/hAMSCs 2D indirect co-culture exhibited increased TNCs expansion, higher percentages of CD34(+) and CD34(+)CD38(-) cells, and better cell vitality when compared to the 2D co-culture.	Alginates	17-25	CD34 molecule	Homo sapiens	144-148
27508284-5	2016	Furthermore, the alginate beads supported CD34(+) cells/hAMSCs 2D indirect co-culture exhibited increased TNCs expansion, higher percentages of CD34(+) and CD34(+)CD38(-) cells, and better cell vitality when compared to the 2D co-culture.	Alginates	17-25	CD34 molecule	Homo sapiens	144-148
26743546-3	2016	In the present study, using immunofluorescence microscopy, we show that anaerobiosis-induced alginate production by planktonic PAO1 requires the diguanylate cyclase (DGC) SadC, previously identified as a regulator of surface-associated lifestyles.	Alginates	93-101	diguanylate cyclase	Pseudomonas aeruginosa PAO1	145-164
27508284-5	2016	Furthermore, the alginate beads supported CD34(+) cells/hAMSCs 2D indirect co-culture exhibited increased TNCs expansion, higher percentages of CD34(+) and CD34(+)CD38(-) cells, and better cell vitality when compared to the 2D co-culture.	Alginates	17-25	CD38 molecule	Homo sapiens	163-167
27508284-6	2016	Therefore, the co-culture system based on encapsulated hAMSCs within alginate beads can effectively promote CD34(+) cells to expand ex vivo.	Alginates	69-77	CD34 molecule	Homo sapiens	108-112
27581621-0	2016	Bone Morphogenetic Protein-2 Promotes Human Mesenchymal Stem Cell Survival and Resultant Bone Formation When Entrapped in Photocrosslinked Alginate Hydrogels.	Alginates	139-147	bone morphogenetic protein 2	Homo sapiens	0-28
27372261-0	2016	Adsorption of As(III), As(V) and Cu(II) on zirconium oxide immobilized alginate beads in aqueous phase.	Alginates	71-79	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	23-28
26743546-3	2016	In the present study, using immunofluorescence microscopy, we show that anaerobiosis-induced alginate production by planktonic PAO1 requires the diguanylate cyclase (DGC) SadC, previously identified as a regulator of surface-associated lifestyles.	Alginates	93-101	diguanylate cyclase	Pseudomonas aeruginosa PAO1	166-169
27002591-1	2016	BACKGROUND: The purpose of the present study was to determine whether polaprezinc suspension in sodium alginate (P-AG) reduces the irradiation period and time to discharge after completion of radiotherapy in patients with head and neck cancer.	Alginates	96-111	phosphoprotein membrane anchor with glycosphingolipid microdomains 1	Homo sapiens	113-117
27296843-0	2016	Sulfated alginate microspheres associate with factor H and dampen the inflammatory cytokine response.	Alginates	9-17	complement factor H	Homo sapiens	46-54
27296843-4	2016	The sulfated alginate microbeads exhibited a complement inert nature with no induction of terminal complement complex (TCC) above the values in freshly drawn blood and low surface accumulation of C3/C3b/iC3b.	Alginates	13-21	complement C3	Homo sapiens	199-202
27296843-6	2016	A common thread was an increased association of the complement inhibitor factor H to the alginate microbeads and microcapsules containing sulfated alginates.	Alginates	89-97	complement factor H	Homo sapiens	73-81
27296843-6	2016	A common thread was an increased association of the complement inhibitor factor H to the alginate microbeads and microcapsules containing sulfated alginates.	Alginates	147-156	complement factor H	Homo sapiens	73-81
27296843-7	2016	Factor H was also found to associate to non-sulfated alginate microbeads in lower amounts, indicating factor H binding as an inherent property of alginate.	Alginates	53-61	complement factor H	Homo sapiens	0-8
27296843-7	2016	Factor H was also found to associate to non-sulfated alginate microbeads in lower amounts, indicating factor H binding as an inherent property of alginate.	Alginates	146-154	complement factor H	Homo sapiens	0-8
27296843-8	2016	We conclude that the dampening effect on the cytokine response and increased factor H association points to sulfated alginate as a promising strategy for improving the biocompatibility of alginate microspheres.	Alginates	117-125	complement factor H	Homo sapiens	77-85
27318817-8	2016	Moreover, after 10 cycles of hydrolysis, 96.4% of the XCA colloids remain inside the alginate beads and retain 67% of the original activity.	Alginates	85-93	X chromosome controlling element	Homo sapiens	54-57
28192295-2	2016	The research is done in the example of alginate hydrogel stained with viscosity-sensitive dyes Seta-470 and Seta-560 as well as the viscosity-insensitive dye Seta-650.	Alginates	39-47	SH3 domain-containing kinase-binding protein 1	Rattus norvegicus	95-99
28192295-2	2016	The research is done in the example of alginate hydrogel stained with viscosity-sensitive dyes Seta-470 and Seta-560 as well as the viscosity-insensitive dye Seta-650.	Alginates	39-47	SH3 domain-containing kinase-binding protein 1	Rattus norvegicus	108-112
28192295-2	2016	The research is done in the example of alginate hydrogel stained with viscosity-sensitive dyes Seta-470 and Seta-560 as well as the viscosity-insensitive dye Seta-650.	Alginates	39-47	SH3 domain-containing kinase-binding protein 1	Rattus norvegicus	108-112
27434585-9	2016	Furthermore, TetOn-HGF/hUCB-MSCs encapsulated by arginine-glycine-aspartic acid (RGD)-alginate microgel induced to express HGF improved in vivo angiogenesis in a mouse hindlimb ischemia model.	Alginates	86-94	hepatocyte growth factor	Homo sapiens	19-22
27434585-9	2016	Furthermore, TetOn-HGF/hUCB-MSCs encapsulated by arginine-glycine-aspartic acid (RGD)-alginate microgel induced to express HGF improved in vivo angiogenesis in a mouse hindlimb ischemia model.	Alginates	86-94	hepatocyte growth factor	Mus musculus	123-126
27136256-4	2016	METHODS AND RESULTS: Using several in vitro intestinal models, it is evident that only one alginate (Manucol LD) of the panel tested was able to inhibit intracellular iron accumulation as assessed by iron-mediated ferritin induction, transferrin receptor expression, intracellular (59) Fe concentrations, and iron flux across a Caco-2 monolayer.	Alginates	91-99	transferrin	Mus musculus	234-245
27647994-8	2016	mRNA expression of Muc1-4 was increased in indomethacin-induced SII, and these increases were prevented by sodium alginate.	Alginates	107-122	endomucin	Mus musculus	19-25
27189137-0	2016	Transplantation of testicular tissue in alginate hydrogel loaded with VEGF nanoparticles improves spermatogonial recovery.	Alginates	40-48	vascular endothelial growth factor A	Homo sapiens	70-74
27400260-0	2016	Alginate-containing systems for oral delivery of superoxide dismutase.	Alginates	0-8	superoxide dismutase 1	Homo sapiens	49-69
27400260-2	2016	The regularities of release of therapeutic antioxidant enzyme superoxide dismutase (SOD) from various alginate-based delivery systems (DS) into simulated gastric and intestinal fluids were determined.	Alginates	102-110	superoxide dismutase 1	Homo sapiens	62-82
27400260-2	2016	The regularities of release of therapeutic antioxidant enzyme superoxide dismutase (SOD) from various alginate-based delivery systems (DS) into simulated gastric and intestinal fluids were determined.	Alginates	102-110	superoxide dismutase 1	Homo sapiens	84-87
27622181-7	2016	RESULTS: Under the lower serum culture, IVD cells in alginate beads showed upregulation of MMP 2, 3, 9, 13 mRNA.	Alginates	53-61	matrix metallopeptidase 2	Homo sapiens	91-96
27441692-0	2016	Sustained Delivery of Bioactive GDNF from Collagen and Alginate-Based Cell-Encapsulating Gel Promoted Photoreceptor Survival in an Inherited Retinal Degeneration Model.	Alginates	55-63	glial cell derived neurotrophic factor	Rattus norvegicus	32-36
27189137-11	2016	Spermatogonial recovery ranged between 14.8% and 27.3% on day 21 and was significantly higher in the alginate and alginate-VEGF-NP groups.	Alginates	114-122	vascular endothelial growth factor A	Homo sapiens	123-127
27037477-0	2016	The impact of functionalized CNT in the network of sodium alginate-based nanocomposite beads on the removal of Co(II) ions from aqueous solutions.	Alginates	51-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-117
27391570-5	2016	Consistently, mice with p16(Ink4a) promoter-driven luciferase, developed bright luminescence of their peritoneal cavity within two weeks following implantation of SCs embedded in alginate beads.	Alginates	179-187	cyclin dependent kinase inhibitor 2A	Mus musculus	24-27
26881299-3	2016	We examined this hypothesis by modifying alginate with a controlled number of sulfates and using it to derive a complex with vascular endothelial growth factor (VEGF), as confirmed with fluorescence resonance energy transfer (FRET) assay.	Alginates	41-49	vascular endothelial growth factor A	Mus musculus	125-159
26881299-3	2016	We examined this hypothesis by modifying alginate with a controlled number of sulfates and using it to derive a complex with vascular endothelial growth factor (VEGF), as confirmed with fluorescence resonance energy transfer (FRET) assay.	Alginates	41-49	vascular endothelial growth factor A	Mus musculus	161-165
27113576-0	2016	Hybrid Polycaprolactone/Alginate Scaffolds Functionalized with VEGF to Promote de Novo Vessel Formation for the Transplantation of Islets of Langerhans.	Alginates	24-32	vascular endothelial growth factor A	Gallus gallus	63-67
27391570-5	2016	Consistently, mice with p16(Ink4a) promoter-driven luciferase, developed bright luminescence of their peritoneal cavity within two weeks following implantation of SCs embedded in alginate beads.	Alginates	179-187	cyclin dependent kinase inhibitor 2A	Mus musculus	28-33
27144389-2	2016	Alginate microcapsules coated with poly-l-ornithine can be used to encapsulate islets in an environment that allows diffusion of glucose, insulin, nutrients, and waste products while inhibiting cells and antibodies.	Alginates	0-8	insulin	Homo sapiens	138-145
26610684-0	2016	Heme Iron Release from Alginate Beads at In Vitro Simulated Gastrointestinal Conditions.	Alginates	23-31	HEME	Bos taurus	0-4
26610684-1	2016	Heme iron (Fe) release from alginate beads at in vitro simulated gastrointestinal conditions for potential use as oral heme Fe supplement was studied.	Alginates	28-36	HEME	Bos taurus	0-4
27074369-0	2016	Dual chitosan/albumin-coated alginate/dextran sulfate nanoparticles for enhanced oral delivery of insulin.	Alginates	29-37	albumin	Homo sapiens	14-21
26930142-7	2016	In vivo, the potential of miR-221 silenced hMSCs was investigated by first encapsulating the cells in alginate and then by filling a cartilage defect in an osteochondral biopsy.	Alginates	102-110	microRNA 221	Homo sapiens	26-33
26930142-8	2016	After implanting the biopsy subcutaneously in nude mice, we found that silencing of miR-221 strongly enhanced in vivo cartilage repair compared to the control conditions (untreated hMSCs or alginate-only).	Alginates	190-198	microRNA 221	Mus musculus	84-91
27074369-0	2016	Dual chitosan/albumin-coated alginate/dextran sulfate nanoparticles for enhanced oral delivery of insulin.	Alginates	29-37	insulin	Homo sapiens	98-105
27375374-0	2016	Chitosan-Alginate Microcapsules Provide Gastric Protection and Intestinal Release of ICAM-1-Targeting Nanocarriers, Enabling GI Targeting In Vivo.	Alginates	9-17	intercellular adhesion molecule 1	Mus musculus	85-91
27028511-6	2016	As shown for several other AMPs, ApoE (133-150) is structured in the presence of TFE and of membrane-mimicking agents, like SDS, or bacterial surface lipopolysaccharide (LPS), and an anionic polysaccharide, alginate, which mimics anionic capsular exo-polysaccharides of several pathogenic microorganisms.	Alginates	207-215	apolipoprotein E	Homo sapiens	33-37
27091175-6	2016	Cell proliferation and specific marker protein expression results also revealed that with the help of sodium citrate degradation, the printed HCECs showed a higher proliferation rate and greater cytokeratin 3(CK3) expression, indicating that this newly developed method may help to improve the alginate bioink system for the application of 3D bioprinting in tissue engineering.	Alginates	294-302	keratin 3	Homo sapiens	195-208
27206764-6	2016	Recombinant human BMP-2 was dissolved in different hydrogels as a carrier, namely gelatin and alginate cross-linked with CaCl2-solution, or a solution of GDL and CaCO3.	Alginates	94-102	bone morphogenetic protein 2	Homo sapiens	18-23
27206764-9	2016	Using a directional vacuum, the samples were loaded with the alginate-BMP-2-mixture and the loading success monitored by observing changes in a fluorescent dye (FITC labeled Protein A) under a fluorescence microscope.	Alginates	61-69	bone morphogenetic protein 2	Homo sapiens	70-75
27206764-14	2016	Using alginate hardened with CaCl2 as a carrier, BMP-2"s release can be decelerated significantly longer than with other hydrogels - eg, for over 28 days.	Alginates	6-14	bone morphogenetic protein 2	Homo sapiens	49-54
26774374-1	2016	Galactosylated alginate-curcumin conjugate (LANH2-Alg Ald-Cur) is synthesized for targeted delivery of curcumin to hepatocytes exploiting asialoglycoprotein receptor (ASGPR) on hepatocytes.	Alginates	15-23	asialoglycoprotein receptor 1	Homo sapiens	138-165
26774374-1	2016	Galactosylated alginate-curcumin conjugate (LANH2-Alg Ald-Cur) is synthesized for targeted delivery of curcumin to hepatocytes exploiting asialoglycoprotein receptor (ASGPR) on hepatocytes.	Alginates	15-23	asialoglycoprotein receptor 1	Homo sapiens	167-172
26952484-5	2016	Compared with the control Alginate, the SrHA/Alginate enhanced MC3T3-E1 cell proliferation and ALP activity by releasing osteoinductive and osteogenic Sr ions.	Alginates	45-53	alopecia, recessive	Mus musculus	95-98
27079852-0	2016	Gene Delivery of TGF-beta3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering.	Alginates	52-60	transforming growth factor beta 3	Homo sapiens	17-26
27079852-0	2016	Gene Delivery of TGF-beta3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering.	Alginates	52-60	bone morphogenetic protein 2	Homo sapiens	31-35
27079852-10	2016	Together, these results suggest that the developed gene-activated alginate hydrogels were able to support transfection of encapsulated MSCs and directed their phenotype toward either a chondrogenic or an osteogenic phenotype depending on whether TGF-beta3 and BMP2 were delivered in combination or isolation.	Alginates	66-74	transforming growth factor beta 3	Homo sapiens	246-255
27079852-10	2016	Together, these results suggest that the developed gene-activated alginate hydrogels were able to support transfection of encapsulated MSCs and directed their phenotype toward either a chondrogenic or an osteogenic phenotype depending on whether TGF-beta3 and BMP2 were delivered in combination or isolation.	Alginates	66-74	bone morphogenetic protein 2	Homo sapiens	260-264
27091175-6	2016	Cell proliferation and specific marker protein expression results also revealed that with the help of sodium citrate degradation, the printed HCECs showed a higher proliferation rate and greater cytokeratin 3(CK3) expression, indicating that this newly developed method may help to improve the alginate bioink system for the application of 3D bioprinting in tissue engineering.	Alginates	294-302	keratin 3	Homo sapiens	209-212
26933083-9	2016	Intramyocardial-targeted delivery of the vascular endothelial growth factor receptor 3-selective designer protein VEGF-CC152S, using albumin-alginate microparticles, accelerated cardiac lymphangiogenesis in a dose-dependent manner and limited precollector remodeling post-MI.	Alginates	141-149	Fms related receptor tyrosine kinase 4	Rattus norvegicus	41-86
26933083-9	2016	Intramyocardial-targeted delivery of the vascular endothelial growth factor receptor 3-selective designer protein VEGF-CC152S, using albumin-alginate microparticles, accelerated cardiac lymphangiogenesis in a dose-dependent manner and limited precollector remodeling post-MI.	Alginates	141-149	vascular endothelial growth factor A	Rattus norvegicus	114-118
26880118-2	2016	In this study, we demonstrate that hepatocellular carcinoma (HCC) cells in porous alginate scaffolds can generate organoid-like spheroids that mimic numerous features of glandular epithelium in vivo, such as acinar morphogenesis and apical expression patterns of EpCAM, a hepatic stem/progenitor cell marker highly expressed in a subset of HCC with stemness features.	Alginates	82-90	epithelial cell adhesion molecule	Homo sapiens	263-268
26743836-2	2016	With the aim of producing a bioactive material for orthopedic applications, a transforming growth factor-beta (TGF- beta1)/hydroxyapatite (HA) association within an alginate-based scaffold was investigated.	Alginates	165-173	transforming growth factor beta 1	Homo sapiens	111-121
26774574-1	2016	In this study, we develop a facile one-pot approach to the fabrication of poly(L-lactic acid) (PLLA) microsphere-incorporated calcium alginate (ALG-Ca)/hydroxyapatite (HAp) porous scaffolds based on HAp nanoparticle-stabilized oil-in-water Pickering emulsion templates, which contain alginate in the aqueous phase and PLLA in the oil phase.	Alginates	126-142	retinoic acid receptor, beta	Mus musculus	199-202
26774574-2	2016	The emulsion aqueous phase is solidified by in situ gelation of alginate with Ca(2+) released from HAp by decreasing pH with slow hydrolysis of D-gluconic acid delta-lactone (GDL) to produce emulsion droplet-incorporated gels, followed by freeze-drying to form porous scaffolds containing microspheres.	Alginates	64-72	retinoic acid receptor, beta	Mus musculus	99-102
26745613-3	2016	To the best of the authors" knowledge, this is the first study to examine the combined effect of sustained release of PRP from alginate beads on BMP2-modified MSC osteogenic differentiation in vitro and sustained release of PRP alone on a fracture defect model ex vivo as well as its effect on calvarial suture closure.	Alginates	127-135	bone morphogenetic protein 2	Mus musculus	145-149
26745613-5	2016	Self-setting alginate hydrogel carrying PRP was tested on a femur defect model ex vivo.	Alginates	13-21	proline rich protein HaeIII subfamily 1	Mus musculus	40-43
26348251-7	2016	Additionally, alginate-encapsulated transgenic designer cells remained responsive to the release of the pro-inflammatory cytokine tumor necrosis factor (TNF) from the whole-blood culture upon exposure to bacterial lipopolysaccharide (LPS).	Alginates	14-22	tumor necrosis factor	Homo sapiens	130-151
26348251-7	2016	Additionally, alginate-encapsulated transgenic designer cells remained responsive to the release of the pro-inflammatory cytokine tumor necrosis factor (TNF) from the whole-blood culture upon exposure to bacterial lipopolysaccharide (LPS).	Alginates	14-22	tumor necrosis factor	Homo sapiens	153-156
26348251-8	2016	TNF diffused into the alginate capsules, bound to the specific TNF receptors on the transgenic designer cells" surface and triggered the expression of the reporter gene SEAP (human placental secreted alkaline phosphatase) that was rewired to the TNF-specific signaling cascade.	Alginates	22-30	tumor necrosis factor	Homo sapiens	0-3
26271189-4	2016	Among the various compression coats, a blend of CMXG and SAL in a ratio of 1.5:3.5 provided T lag of 5.12 +- 0.09 h and T rap of 6.50 +- 0.05 h. The increase in microcrystalline cellulose (MCC) and crospovidone (CP) in the core tablets did not change T lag significantly although decreased the T rap marginally.	Alginates	57-60	LDL receptor related protein associated protein 1	Homo sapiens	122-125
26271189-4	2016	Among the various compression coats, a blend of CMXG and SAL in a ratio of 1.5:3.5 provided T lag of 5.12 +- 0.09 h and T rap of 6.50 +- 0.05 h. The increase in microcrystalline cellulose (MCC) and crospovidone (CP) in the core tablets did not change T lag significantly although decreased the T rap marginally.	Alginates	57-60	LDL receptor related protein associated protein 1	Homo sapiens	296-299
27007436-0	2016	Injectable hydrogels embedded with alginate microspheres for controlled delivery of bone morphogenetic protein-2.	Alginates	35-43	bone morphogenetic protein 2	Mus musculus	84-112
27007436-1	2016	Some delivery carriers with injectable characteristics were built using the thermosensitive chitosan/dextran-polylactide/glycerophosphate hydrogel and selected alginate microspheres for the controllable release of bone morphogenetic protein-2 (BMP-2).	Alginates	160-168	bone morphogenetic protein 2	Mus musculus	214-242
26652435-4	2016	Here, alginate-chitosan hydrogels are demonstrated to provide controlled delivery of IgG model antibodies and also of Fab antibody fragments.	Alginates	6-14	FA complementation group B	Homo sapiens	118-121
26706437-6	2016	The alginate-coated liposomes achieved a high specific (genuine) mucin interaction, with a low potential of cell-irritation.	Alginates	4-12	LOC100508689	Homo sapiens	65-70
30979105-8	2016	It was also shown that the addition of lysozyme negatively affected the free radical scavenging ability of single hydrosols of alginate and chitosan, and their mixtures.	Alginates	127-135	lysozyme	Homo sapiens	39-47
26652453-0	2016	VEGF-conjugated alginate hydrogel prompt angiogenesis and improve pancreatic islet engraftment and function in type 1 diabetes.	Alginates	16-24	vascular endothelial growth factor A	Homo sapiens	0-4
26652453-4	2016	In this study, we designed and synthesized a vascular endothelial growth factor (VEGF) conjugated alginate material to encapsulate the transplanted islets via 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS) reaction, and successful conjugation was confirmed by Nuclear Magnetic Resonance H1 spectrum.	Alginates	98-106	vascular endothelial growth factor A	Homo sapiens	45-79
26652453-4	2016	In this study, we designed and synthesized a vascular endothelial growth factor (VEGF) conjugated alginate material to encapsulate the transplanted islets via 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS) reaction, and successful conjugation was confirmed by Nuclear Magnetic Resonance H1 spectrum.	Alginates	98-106	vascular endothelial growth factor A	Homo sapiens	81-85
26652453-6	2016	In vivo study, conjugated VEGF on alginate exhibited sustained promoting angiogenesis property after subcutaneous transplantation by histology study and islets encapsulated in this material achieved long term therapeutic effect (up to 50days) in the diabetic mice model.	Alginates	34-42	vascular endothelial growth factor A	Mus musculus	26-30
27057540-7	2016	Alginate gel was combined with miR-146a/PEG-PEI nanoparticles and bFGF.	Alginates	0-8	microRNA 146a	Homo sapiens	31-39
27221930-8	2016	The optimal formula of RIP-MJ nanoparticles was obtained at the concentration of RIP-MJ, low viscosity chitosan and alginate respectively 0.05%, 1%, and 0.4% (m/v).	Alginates	116-124	receptor interacting serine/threonine kinase 1	Homo sapiens	23-26
27057540-7	2016	Alginate gel was combined with miR-146a/PEG-PEI nanoparticles and bFGF.	Alginates	0-8	fibroblast growth factor 2	Homo sapiens	66-70
26348141-11	2015	Here, we show that alginate biomaterials with linear channels that are filled with cells expressing the growth-promoting neurotrophin BDNF promote linear axon extension throughout the channels after transplantation to the injured rat spinal cord.	Alginates	19-27	brain-derived neurotrophic factor	Rattus norvegicus	134-138
26361731-2	2016	Sequential assembly of higher and lower deacetylated chitosans (C1 and C2 ) on alginate has produced AC1 C2 microcapsule with improved membrane strength and biocompatibility.	Alginates	79-87	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	64-73
33429673-2	2015	In this study, we have reported novel composite nanoparticles fabricated with gold nanocluster embedded chitosan and alginate, bound to bacterially expressed human recombinant sFRP1.	Alginates	117-125	secreted frizzled related protein 1	Homo sapiens	176-181
26310669-0	2015	Release of insulin from PLGA-alginate dressing stimulates regenerative healing of burn wounds in rats.	Alginates	29-37	insulin	Homo sapiens	11-18
26310669-3	2015	More recently, we developed an alginate sponge dressing (ASD) containing insulin encapsulated in PLGA [poly(D,L-lactic-co-glycolic acid)] microparticles that provides a sustained release of bioactive insulin for &gt;20 days in a moist and protective environment.	Alginates	31-39	insulin	Homo sapiens	73-80
26310669-3	2015	More recently, we developed an alginate sponge dressing (ASD) containing insulin encapsulated in PLGA [poly(D,L-lactic-co-glycolic acid)] microparticles that provides a sustained release of bioactive insulin for &gt;20 days in a moist and protective environment.	Alginates	31-39	insulin	Homo sapiens	200-207
26726279-4	2016	Despite this lack of interaction between the mucin and alginate, the addition of alginate had a marked effect on the diffusion of 500 nm probe particles, which decreased as a function of increasing alginate concentration.	Alginates	81-89	LOC100508689	Homo sapiens	45-50
26726279-4	2016	Despite this lack of interaction between the mucin and alginate, the addition of alginate had a marked effect on the diffusion of 500 nm probe particles, which decreased as a function of increasing alginate concentration.	Alginates	81-89	LOC100508689	Homo sapiens	45-50
25272249-3	2016	This study examined the effects of alginate microencapsulation on the protective efficacy of C6-6 against BCWD in vivo when administered to rainbow trout fry orally or by intraperitoneal (IP) injection.	Alginates	35-43	complement component C6	Oncorhynchus mykiss	93-97
25180953-0	2015	Effect of Calcium Alginate Microsphere Loaded With Vascular Endothelial Growth Factor on Adipose Tissue Transplantation.	Alginates	10-26	WD and tetratricopeptide repeats 1	Mus musculus	89-96
25180953-4	2015	We constructed calcium alginate (CA) microspheres loaded with VEGF to increase the survival of implanted adipocytes.	Alginates	15-31	vascular endothelial growth factor A	Mus musculus	62-66
26164724-5	2015	The highly stable alginate nanoparticles, characterized by various microscopic and spectroscopic techniques, exhibited a maximum uptake capacity of 333 mg g (-1)of Pb(II) ions from aqueous solution.	Alginates	18-26	submaxillary gland androgen regulated protein 3B	Homo sapiens	164-170
26134557-3	2015	Effect of bone morphogenetic protein 13 on human derived nucleus pulposus, annulus fibrosus and endplate cells cultured in alginate beads was evaluated by changes in proteoglycan and collagen content.	Alginates	123-131	growth differentiation factor 6	Homo sapiens	10-39
26134557-5	2015	Bone morphogenetic protein 13 induced significant proteoglycan accumulation in nucleus (18%), annulus (21%) and endplate (23%) cells cultured in alginate beads (p&lt;0.05) compared to controls.	Alginates	145-153	growth differentiation factor 6	Homo sapiens	0-29
26386487-10	2015	Above all, we hypothesized that neuroblastoma cells and bFGF encapsulated in multilayered alginate microcapsules may efficiently induce the differentiation of BMSCs into NPCs.	Alginates	90-98	fibroblast growth factor 2	Homo sapiens	56-60
26434999-7	2015	The alginate bilayer films containing Hidrox( ), HB2, showed controlled release of hydroxytyrosol at a flux of 0.094+-0.009 mg/cm(2)/h.	Alginates	4-12	keratin 82	Homo sapiens	49-52
26504589-6	2015	RESULT: For co-encapsulation of HMGB1 A box protein with islets, we evaluated the distribution of alginate bead diameter.	Alginates	98-106	high mobility group box 1	Mus musculus	32-37
26504589-9	2015	When the alginate beads with islets plus HMGB1 A box protein were cultured with macrophage, the amount of TNF-alpha secreted from the macrophages was significantly attenuated when compared to cultivation of unencapsulated islets or encapsulated islets.	Alginates	9-17	tumor necrosis factor	Mus musculus	106-115
26504384-3	2015	Lactoferrin (Lf) is a natural milk protein, which has shown antimicrobial properties in its nanoformulation using alginate chitosan calcium phosphate bovine lactoferrin nanocapsules (AEC-CCo-CP-bLf-NCs).	Alginates	114-122	lactotransferrin	Bos taurus	0-11
26504384-3	2015	Lactoferrin (Lf) is a natural milk protein, which has shown antimicrobial properties in its nanoformulation using alginate chitosan calcium phosphate bovine lactoferrin nanocapsules (AEC-CCo-CP-bLf-NCs).	Alginates	114-122	lactotransferrin	Bos taurus	13-15
26750016-13	2015	CONCLUSION: hUCMSCs can continuously express VEGF in alginate gel, which is necessary for wound healing.	Alginates	53-61	vascular endothelial growth factor A	Homo sapiens	45-49
26242686-12	2015	In vitro testing showed PB-TCA-SA microcapsules improved beta-cell survival under hyperglycemic states and reduced the pro-inflammatory cytokine TNF-alpha while increasing insulin secretions compared with PB-SA microcapsules.	Alginates	31-33	tumor necrosis factor	Mus musculus	145-154
26372641-0	2015	In Situ Transplantation of Alginate Bioencapsulated Adipose Tissues Derived Stem Cells (ADSCs) via Hepatic Injection in a Mouse Model.	Alginates	27-35	WD and tetratricopeptide repeats 1	Mus musculus	52-59
26348665-3	2015	The bioavailability of key GFs, such as Epidermal Growth factor (EGF) and basic Fibroblast Growth Factor (bFGF) released from injected alginate biomaterial to the central lesion site significantly enhanced the sparing of spinal cord tissue and increased the number of surviving neurons (choline acetyltransferase positive motoneurons) and sensory fibres.	Alginates	135-143	fibroblast growth factor 2	Rattus norvegicus	74-104
26348665-3	2015	The bioavailability of key GFs, such as Epidermal Growth factor (EGF) and basic Fibroblast Growth Factor (bFGF) released from injected alginate biomaterial to the central lesion site significantly enhanced the sparing of spinal cord tissue and increased the number of surviving neurons (choline acetyltransferase positive motoneurons) and sensory fibres.	Alginates	135-143	fibroblast growth factor 2	Rattus norvegicus	106-110
26054564-5	2015	Bone morphogenetic protein 2 (BMP2) was loaded in the core, while the shell incorporated Co ions, enabled by the alginate crosslinking in CoCl2/CaCl2 solution.	Alginates	113-121	bone morphogenetic protein 2	Rattus norvegicus	0-28
26121308-0	2015	Serum Albumin-Alginate Microparticles Prepared by Transacylation: Relationship between Physicochemical, Structural and Functional Properties.	Alginates	14-22	albumin	Homo sapiens	0-13
27057439-4	2016	In two cancer models, B16-F10 melanoma and 4T1 metastatic breast cancer, the alginate hydrogel delivery system significantly improves the antitumor activities of celecoxib (CXB), PD-1 mAb, or both combined.	Alginates	77-85	programmed cell death 1	Mus musculus	179-183
27057439-9	2016	This alginate-hydrogel-mediated, combinatorial therapy of celecoxib and PD-1 mAb provides a potential valuable regimen for treating human cancer.	Alginates	5-13	programmed cell death 1	Mus musculus	72-76
25797848-0	2015	Synthesis of cadmium, lead and copper alginate nanobeads as immunosensing probes for the detection of AFP, CEA and PSA.	Alginates	31-46	alpha fetoprotein	Homo sapiens	102-105
25797848-0	2015	Synthesis of cadmium, lead and copper alginate nanobeads as immunosensing probes for the detection of AFP, CEA and PSA.	Alginates	31-46	CEA cell adhesion molecule 3	Homo sapiens	107-110
25797848-0	2015	Synthesis of cadmium, lead and copper alginate nanobeads as immunosensing probes for the detection of AFP, CEA and PSA.	Alginates	31-46	aminopeptidase puromycin sensitive	Homo sapiens	115-118
25797848-3	2015	Using the novel alginate nanobeads labeled with antibodies as electrochemical probes, a sandwich-type immunosensor was constructed using AFP, CEA and PSA as model analytes.	Alginates	16-24	alpha fetoprotein	Homo sapiens	137-140
25797848-3	2015	Using the novel alginate nanobeads labeled with antibodies as electrochemical probes, a sandwich-type immunosensor was constructed using AFP, CEA and PSA as model analytes.	Alginates	16-24	CEA cell adhesion molecule 3	Homo sapiens	142-145
25797848-3	2015	Using the novel alginate nanobeads labeled with antibodies as electrochemical probes, a sandwich-type immunosensor was constructed using AFP, CEA and PSA as model analytes.	Alginates	16-24	aminopeptidase puromycin sensitive	Homo sapiens	150-153
26085382-0	2015	3D-Printed Atsttrin-Incorporated Alginate/Hydroxyapatite Scaffold Promotes Bone Defect Regeneration with TNF/TNFR Signaling Involvement.	Alginates	33-41	tumor necrosis factor	Mus musculus	105-108
26039892-1	2015	Monodisperse alginate microgels (10-50 mum) are created via droplet-based microfluidics by a novel crosslinking procedure.	Alginates	13-21	latexin	Homo sapiens	39-42
26085382-0	2015	3D-Printed Atsttrin-Incorporated Alginate/Hydroxyapatite Scaffold Promotes Bone Defect Regeneration with TNF/TNFR Signaling Involvement.	Alginates	33-41	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	109-113
26085382-4	2015	Hence, this study investigates whether 3D-printed Atsttrin-incorporated alginate(Alg)/hydroxyapatite(nHAp) scaffolds can facilitate bone healing through affecting the TNF/TNFR signaling.	Alginates	72-80	tumor necrosis factor	Mus musculus	167-170
26085382-4	2015	Hence, this study investigates whether 3D-printed Atsttrin-incorporated alginate(Alg)/hydroxyapatite(nHAp) scaffolds can facilitate bone healing through affecting the TNF/TNFR signaling.	Alginates	72-80	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	171-175
26239837-3	2015	In this study, we evaluated the effects of the alginate extract named CTX in OA cell and rabbit models.	Alginates	47-55	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	70-73
26239837-4	2015	RESULTS: CTX was formulated by hydrolyzing sodium alginate polymers with alginate lyase and then mixing with pectin.	Alginates	43-58	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	9-12
26239837-11	2015	CONCLUSIONS: The gene expression profiles in the cell and the examinations done on the rabbit cartilage suggest that the alginate extract CTX is a pharmaco-therapeutic agent applicable for OA therapy.	Alginates	121-129	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	138-141
26004232-0	2015	Macrophage repolarization with targeted alginate nanoparticles containing IL-10 plasmid DNA for the treatment of experimental arthritis.	Alginates	40-48	interleukin 10	Rattus norvegicus	74-79
26040897-5	2015	Extensively, soleus muscle necrosis was induced in rats by bupivacaine, and an injectable alginate gel was used to release the PSP in the injured muscle.	Alginates	90-98	regenerating family member 1 alpha	Rattus norvegicus	127-130
26004232-2	2015	An anti-inflammatory (IL-10) cytokine encoding plasmid DNA was successfully encapsulated into non-condensing alginate based nanoparticles and the surface of the nano-carriers was modified with tuftsin peptide to achieve active macrophage targeting.	Alginates	109-117	interleukin 10	Rattus norvegicus	22-27
26004232-4	2015	Importantly, targeted nanoparticle treatment was successful in reprogramming macrophage phenotype balance as ~66% of total synovial macrophages from arthritic rats treated with the IL-10 plasmid DNA loaded tuftsin/alginate nanoparticles were in the M2 state compared to ~9% of macrophages in the M2 state from untreated arthritic rats.	Alginates	214-222	interleukin 10	Rattus norvegicus	181-186
26004232-7	2015	Overall, this study demonstrates that targeted alginate nanoparticles loaded with IL-10 plasmid DNA can efficiently re-polarize macrophages from an M1 to an M2 state, offering a novel treatment paradigm for treatment of chronic inflammatory diseases.	Alginates	47-55	interleukin 10	Rattus norvegicus	82-87
26251592-5	2015	Both BIO and IGF-1 were efficiently encapsulated in gelatin nanoparticles, which were later cross-linked with the oxidized alginate to form a novel hybrid hydrogel system.	Alginates	123-131	insulin-like growth factor 1	Rattus norvegicus	13-18
26095915-8	2015	These findings suggest thiolated alginate as promising auxiliary agent for drugs being anionic efflux pump substrates, since the oral bioavailability of a MRP2 substrate could be significantly improved.	Alginates	33-41	ATP binding cassette subfamily C member 2	Rattus norvegicus	155-159
23956230-3	2015	Epidermal growth factor (EGF) and fibroblast growth factor-2 (bFGF) were affinity-bound to alginate-sulphate (200 ng/scaffold) and the bioconjugates were mixed with partially calcium-crosslinked alginate.	Alginates	91-99	epidermal growth factor	Rattus norvegicus	25-28
23956230-3	2015	Epidermal growth factor (EGF) and fibroblast growth factor-2 (bFGF) were affinity-bound to alginate-sulphate (200 ng/scaffold) and the bioconjugates were mixed with partially calcium-crosslinked alginate.	Alginates	91-99	fibroblast growth factor 2	Rattus norvegicus	62-66
26238410-0	2015	An in vitro study of peptide-loaded alginate nanospheres for antagonizing the inhibitory effect of Nogo-A protein on axonal growth.	Alginates	36-44	reticulon 4	Homo sapiens	99-105
26238410-4	2015	Alginate nanospheres were fabricated using an emulsion technique and loaded with Nogo receptor-blocking peptide, or with other model proteins.	Alginates	0-8	reticulon 4 receptor	Homo sapiens	81-94
26238410-7	2015	Our results demonstrate that peptide released from alginate nanospheres could overcome the growth inhibitory effect of Nogo-A, suggesting that a similar peptide delivery strategy using alginate nanospheres might be used to improve axon regeneration within the injured central nervous system.	Alginates	51-59	reticulon 4	Homo sapiens	119-125
26238410-7	2015	Our results demonstrate that peptide released from alginate nanospheres could overcome the growth inhibitory effect of Nogo-A, suggesting that a similar peptide delivery strategy using alginate nanospheres might be used to improve axon regeneration within the injured central nervous system.	Alginates	185-193	reticulon 4	Homo sapiens	119-125
26031743-10	2015	Hepatocyte growth factor mRNA was increased in ASCs cultivated in alginates compared with monolayer controls.	Alginates	66-75	hepatocyte growth factor	Homo sapiens	0-24
26487861-6	2015	beta-Tubulin and CD271 expression levels were significantly greater in the WJMSCs cultured in the three-dimensional alginate scaffold than in the conventional two-dimensional culture condition.	Alginates	116-124	nerve growth factor receptor	Homo sapiens	17-22
26214286-7	2015	We conclude that the addition of stromal cell-derived factor-1alpha to a cell-seeded alginate based bone morphogenetic protein-2 plasmid DNA construct has an additive effect on bone formation and can be considered a promising combination for bone regeneration.	Alginates	85-93	bone morphogenetic protein 2	Mus musculus	100-128
25941779-7	2015	Separately, the bimodal gel loaded with microparticles releasing vascular endothelial growth factor stimulated vascular growth solely into microchannels of the RGD-alginate gel blocks in vivo.	Alginates	164-172	vascular endothelial growth factor A	Homo sapiens	65-99
26146432-0	2015	Biological activity of alginate and its effect on pancreatic lipase inhibition as a potential treatment for obesity.	Alginates	23-31	pancreatic lipase	Homo sapiens	50-67
26068280-1	2015	Alginate-based amphiphilic graft copolymers were synthesized by single electron transfer living radical polymerization (SET-LRP), forming stable micelles during polymerization induced self-assembly (PISA).	Alginates	0-8	LDL receptor related protein 1	Homo sapiens	124-127
26068280-6	2015	As the first reported case of LRP from alginate, this work introduces a synthetic route to a preparation of alginate-based hybrid polymers with a precise macromolecular architecture and desired functionalities.	Alginates	39-47	LDL receptor related protein 1	Homo sapiens	30-33
26068280-6	2015	As the first reported case of LRP from alginate, this work introduces a synthetic route to a preparation of alginate-based hybrid polymers with a precise macromolecular architecture and desired functionalities.	Alginates	108-116	LDL receptor related protein 1	Homo sapiens	30-33
26068280-7	2015	The intended application is the preparation of micelles for drug delivery; however, LRP from alginate can also be applied in the field of biomaterials to the improvement of alginate-based hydrogel systems such as nano- and microhydrogel particles, islet encapsulation materials, hydrogel implants, and topical applications.	Alginates	93-101	LDL receptor related protein 1	Homo sapiens	84-87
26068280-7	2015	The intended application is the preparation of micelles for drug delivery; however, LRP from alginate can also be applied in the field of biomaterials to the improvement of alginate-based hydrogel systems such as nano- and microhydrogel particles, islet encapsulation materials, hydrogel implants, and topical applications.	Alginates	173-181	LDL receptor related protein 1	Homo sapiens	84-87
25958832-0	2015	Identification of IL-1beta and LPS as optimal activators of monolayer and alginate-encapsulated mesenchymal stromal cell immunomodulation using design of experiments and statistical methods.	Alginates	74-82	interleukin 1 beta	Homo sapiens	18-26
25424733-3	2015	Alginate hydrogels with HNTs doped with BMP-2, 4, or 6 only or BMP-4 and 6 in combination.	Alginates	0-8	bone morphogenetic protein 2	Homo sapiens	40-48
25893351-7	2015	The BMP-2 was delivered using heparin-modified alginate microbeads loaded into biodegradable cage.	Alginates	47-55	bone morphogenetic protein 2	Sus scrofa	4-9
26730315-7	2015	hRPE cells were cultured at a density of 2 x 105 cells/well in alginate-coated microplates.	Alginates	63-71	ribulose-5-phosphate-3-epimerase	Homo sapiens	0-4
26730315-14	2015	The hRPE cells survived unlimitedly on alginate film and formed giant adjoining colonies.	Alginates	39-47	ribulose-5-phosphate-3-epimerase	Homo sapiens	4-8
26730315-16	2015	CONCLUSION: Alginate film can support the survival and growth of hRPE cells and induce the cells to re-organize in tissue-like structures.	Alginates	12-20	ribulose-5-phosphate-3-epimerase	Homo sapiens	65-69
25958179-4	2015	The alginate hydrogel also retained and delivered 2 key growth factors, vascular endothelial growth factor-121 and fibroblast growth factor, in a sufficient amount to induce proliferation.	Alginates	4-12	vascular endothelial growth factor A	Homo sapiens	72-106
25907048-5	2015	CAFs were encapsulated in alginate/gelatine beads (500-750 mum in diameter) functionalised with a polyelectrolyte coating (MP[CAF]).	Alginates	26-34	T-box transcription factor 1	Homo sapiens	0-4
25843845-0	2015	Work of adhesion between mucin macromolecule and calcium-alginate gels on molecular level.	Alginates	49-65	LOC100508689	Homo sapiens	25-30
25843845-2	2015	Herein we use AFM force measurements to evaluate the interaction on molecular level between a mucin macromolecule attached to an AFM tip and a calcium-alginate gel layer.	Alginates	143-159	LOC100508689	Homo sapiens	94-99
26110792-8	2015	We show here that intraocular objects like dimensionally stable spherical alginate capsules allow for a two-dimensional calibration of the acquired OCT raw images by establishing a relation between X and Y axis data.	Alginates	74-82	plexin A2	Mus musculus	148-151
26110792-11	2015	As an exemplary case, we provide data for a two-dimensional in vivo OCT image calibration in mice using intraocular alginate capsules.	Alginates	116-124	plexin A2	Mus musculus	68-71
26041143-0	2015	Heparin-conjugated alginate multilayered microspheres for controlled release of bFGF.	Alginates	19-27	fibroblast growth factor 2	Mus musculus	80-84
26041143-1	2015	In order to effectively immobilize and control release of basic fibroblast growth factor (bFGF) from alginate microspheres, heparin-conjugated alginate (H-Alg) was first synthesized by covalent binding.	Alginates	101-109	fibroblast growth factor 2	Mus musculus	58-88
26041143-1	2015	In order to effectively immobilize and control release of basic fibroblast growth factor (bFGF) from alginate microspheres, heparin-conjugated alginate (H-Alg) was first synthesized by covalent binding.	Alginates	101-109	fibroblast growth factor 2	Mus musculus	90-94
26041143-1	2015	In order to effectively immobilize and control release of basic fibroblast growth factor (bFGF) from alginate microspheres, heparin-conjugated alginate (H-Alg) was first synthesized by covalent binding.	Alginates	143-151	fibroblast growth factor 2	Mus musculus	58-88
26041143-1	2015	In order to effectively immobilize and control release of basic fibroblast growth factor (bFGF) from alginate microspheres, heparin-conjugated alginate (H-Alg) was first synthesized by covalent binding.	Alginates	143-151	fibroblast growth factor 2	Mus musculus	90-94
26041143-5	2015	It was found that the bFGF binding efficiency of H-Alg microspheres was increased up to five times higher than that of the alginate microspheres.	Alginates	123-131	fibroblast growth factor 2	Mus musculus	22-26
25896537-1	2015	Glucose oxidase (GOX) encapsulated in alginate-chitosan microspheres (GOX-MS) was shown in our previous work to produce reactive oxygen species (ROS) in situ and exhibit anticancer effects in vitro and in vivo.	Alginates	38-46	hydroxyacid oxidase 1, liver	Mus musculus	0-15
25896537-1	2015	Glucose oxidase (GOX) encapsulated in alginate-chitosan microspheres (GOX-MS) was shown in our previous work to produce reactive oxygen species (ROS) in situ and exhibit anticancer effects in vitro and in vivo.	Alginates	38-46	hydroxyacid oxidase 1, liver	Mus musculus	17-20
25896537-1	2015	Glucose oxidase (GOX) encapsulated in alginate-chitosan microspheres (GOX-MS) was shown in our previous work to produce reactive oxygen species (ROS) in situ and exhibit anticancer effects in vitro and in vivo.	Alginates	38-46	hydroxyacid oxidase 1, liver	Mus musculus	70-73
26020773-7	2015	The production of IL-6, IL-8 and MMP-3 by chondrocytes significantly decreased in chitosan-alginate beads compared to alginate beads.	Alginates	91-99	interleukin 6	Homo sapiens	18-22
25843239-12	2015	SiNP coated with alginate or chitosan showed high contact with mucin.	Alginates	17-25	LOC100508689	Homo sapiens	63-68
25842137-4	2015	In this paper, we report HAp nanorod crystal synthesized successfully by a biomimetic method using calcium chloride and ammonium dihydrogen phosphate as reagents in the presence of silk fibroin/sodium alginate (SF/SA) fibrous hydrogels.	Alginates	194-209	reticulon 3	Homo sapiens	25-28
26020773-7	2015	The production of IL-6, IL-8 and MMP-3 by chondrocytes significantly decreased in chitosan-alginate beads compared to alginate beads.	Alginates	91-99	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
26020773-7	2015	The production of IL-6, IL-8 and MMP-3 by chondrocytes significantly decreased in chitosan-alginate beads compared to alginate beads.	Alginates	91-99	matrix metallopeptidase 3	Homo sapiens	33-38
25817657-1	2015	Alginate is a linear and acidic polysaccharide, composed of (1   4) linked beta-D-mannuronic acid (ManA) and alpha-L-guluronic acid (GulA).	Alginates	0-8	mannosidase alpha class 2C member 1	Homo sapiens	75-97
25719212-3	2015	Alginate polymer-based nonviral gene therapy with BMP-2 plasmid DNA (pBMP-2) in constructs with multipotent mesenchymal stromal cells (MSCs) has resulted in prolonged gene expression and bone formation in vivo.	Alginates	0-8	bone morphogenetic protein 2	Capra hircus	50-55
25376622-9	2015	In vitro, we observed that alginate-collagen porous scaffolds supported cell proliferation and extracellular matrix deposition (collagen type I), with secretion amplified by the local release of transforming growth factor-beta3.	Alginates	27-35	transforming growth factor beta 3	Homo sapiens	195-227
25637491-0	2015	Chronic delivery of alpha-melanocyte-stimulating hormone in rat hypothalamus using albumin-alginate microparticles: effects on food intake and body weight.	Alginates	91-99	proopiomelanocortin	Rattus norvegicus	20-56
25592844-1	2015	Surface ion-imprinting technique was utilized for the preparation of surface ion-imprinted chelating microspheres based on amidoximated modified alginate (U-AOX) in presence of uranyl ions as a template and glutaraldehyde cross-linker.	Alginates	145-153	acyl-CoA oxidase 1	Homo sapiens	157-160
25637491-8	2015	In conclusion, our study validates albumin-alginate microparticles as a new carrier system for long-term delivery of neuropeptides in the brain and demonstrates that chronic delivery of alpha-MSH in the hypothalamus results in a prolonged suppression of food intake and a decrease of body weight gain in rats.	Alginates	43-51	proopiomelanocortin	Rattus norvegicus	186-195
25583022-0	2015	Alginate-calcium microsphere loaded with thrombin: a new composite biomaterial for hemostatic embolization.	Alginates	0-16	coagulation factor II, thrombin	Homo sapiens	41-49
25583022-4	2015	In this study, a new biodegradable macromolecule material (thrombin-loaded alginate-calcium microspheres, TACMs) was prepared using electrostatic droplet techniques and a special method was developed for hemostatic embolization.	Alginates	75-83	coagulation factor II, thrombin	Homo sapiens	59-67
25542119-1	2015	Spun-dyed alginate fiber was prepared by the spun-dyeing method with the mixture of fluorescent pigment dispersion and sodium alginate fiber spinning solution, and its properties were characterized by SEM, TGA, DSC, and XRD.	Alginates	10-18	T-box transcription factor 1	Homo sapiens	206-209
25434326-2	2015	We hypothesized that local, sustained delivery of exogenous vascular endothelial growth factor (VEGF) and stromal cell-derived factor (SDF) from alginate hydrogels could increase recruitment of systemically infused endothelial progenitors to ischemic tissue, and subsequent neovascularization.	Alginates	145-153	vascular endothelial growth factor A	Homo sapiens	60-94
25563940-1	2015	A photoresponsive hybrid alginate hydrogel was successfully prepared by Ca(2+)-mediated crosslinking reaction with a mixture of beta-cyclodextrin-grafted alginate (beta-CD-Alg) and diazobenzene-modified poly(ethylene glycol) (Az2-PEG).	Alginates	25-33	ornithine decarboxylase antizyme 2	Homo sapiens	226-229
26090086-5	2015	Enamel matrix derivative-enriched alginate hydrogel significantly increased the expression of osteoblast markers COL1A1, TNFRSF11B, and BGLAP and secretion of osteopontin in human osteoblasts, whereas osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells seemed unaffected by enamel matrix derivative.	Alginates	34-42	collagen type I alpha 1 chain	Homo sapiens	113-119
26090086-5	2015	Enamel matrix derivative-enriched alginate hydrogel significantly increased the expression of osteoblast markers COL1A1, TNFRSF11B, and BGLAP and secretion of osteopontin in human osteoblasts, whereas osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells seemed unaffected by enamel matrix derivative.	Alginates	34-42	TNF receptor superfamily member 11b	Homo sapiens	121-130
26090086-5	2015	Enamel matrix derivative-enriched alginate hydrogel significantly increased the expression of osteoblast markers COL1A1, TNFRSF11B, and BGLAP and secretion of osteopontin in human osteoblasts, whereas osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells seemed unaffected by enamel matrix derivative.	Alginates	34-42	bone gamma-carboxyglutamate protein	Homo sapiens	136-141
26090086-5	2015	Enamel matrix derivative-enriched alginate hydrogel significantly increased the expression of osteoblast markers COL1A1, TNFRSF11B, and BGLAP and secretion of osteopontin in human osteoblasts, whereas osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells seemed unaffected by enamel matrix derivative.	Alginates	34-42	secreted phosphoprotein 1	Homo sapiens	159-170
25769043-9	2015	In conclusion, Both ALP-modified and unmodified alginate beads provide an environment that enhance osteogenic differentiation compared with traditional 2D culture.	Alginates	48-56	alkaline phosphatase, placental	Homo sapiens	20-23
25769043-10	2015	Also, the ALP-modified alginate beads showed profound mineralization and thus have the potential to serve as a bone substitute in tissue engineering.	Alginates	23-31	alkaline phosphatase, placental	Homo sapiens	10-13
25542119-1	2015	Spun-dyed alginate fiber was prepared by the spun-dyeing method with the mixture of fluorescent pigment dispersion and sodium alginate fiber spinning solution, and its properties were characterized by SEM, TGA, DSC, and XRD.	Alginates	10-18	desmocollin 3	Homo sapiens	211-214
25542119-4	2015	TGA, DSC, and XRD results suggested that thermal properties and crystal phase of spun-dyed alginate fibers had slight changes compared to the original alginate fibers.	Alginates	91-99	T-box transcription factor 1	Homo sapiens	0-3
25542119-4	2015	TGA, DSC, and XRD results suggested that thermal properties and crystal phase of spun-dyed alginate fibers had slight changes compared to the original alginate fibers.	Alginates	91-99	desmocollin 3	Homo sapiens	5-8
25693473-0	2015	Alginate encapsulant incorporating CXCL12 supports long-term allo- and xenoislet transplantation without systemic immune suppression.	Alginates	0-8	C-X-C motif chemokine ligand 12	Homo sapiens	35-41
25693473-9	2015	These data support the use of CXCL12 as a coating or a component of an alginate encapsulant to induce sustained local immune-isolation for allo- or xenoislet transplantation without systemic immunosuppression.	Alginates	71-79	C-X-C motif chemokine ligand 12	Homo sapiens	30-36
25347385-5	2015	When insulin-like growth factor-1 (IGF-1) was loaded on the coating material alginate, its release from alginate into the medium presented in a time-dependent and pH-dependent way.	Alginates	77-85	insulin like growth factor 1	Homo sapiens	5-33
23860800-12	2015	Accordingly, in both chondrocyte monolayer culture and chondrocytes-alginate hydrogel constructs, the expression of type II collagen was increased significantly in HBP-A group when compared with control group (P&lt;0.001).	Alginates	68-76	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	Mus musculus	164-167
25502925-7	2015	Immunocytochemistry analysis exhibited Nestin, RPE65, and cytokeratin expressions in a reasonable number of cultured cells in alginate beads.	Alginates	126-134	nestin	Homo sapiens	39-45
25502925-8	2015	Real-time PCR data demonstrated high levels of Nestin, CHX10, RPE65, and tyrosinase gene expressions in RPE cells immobilized in alginate when compared to 2D monolayer culture systems.	Alginates	129-137	nestin	Homo sapiens	47-53
25502925-8	2015	Real-time PCR data demonstrated high levels of Nestin, CHX10, RPE65, and tyrosinase gene expressions in RPE cells immobilized in alginate when compared to 2D monolayer culture systems.	Alginates	129-137	visual system homeobox 2	Homo sapiens	55-60
25502925-8	2015	Real-time PCR data demonstrated high levels of Nestin, CHX10, RPE65, and tyrosinase gene expressions in RPE cells immobilized in alginate when compared to 2D monolayer culture systems.	Alginates	129-137	retinoid isomerohydrolase RPE65	Homo sapiens	62-67
25502925-8	2015	Real-time PCR data demonstrated high levels of Nestin, CHX10, RPE65, and tyrosinase gene expressions in RPE cells immobilized in alginate when compared to 2D monolayer culture systems.	Alginates	129-137	tyrosinase	Homo sapiens	73-83
26113881-2	2015	Alcohol dehydrogenase was immobilized, embedded in an alginate-silicate hybrid gel, on a carbon felt (CF) electrode.	Alginates	54-62	aldo-keto reductase family 1 member A1	Homo sapiens	0-21
25347385-5	2015	When insulin-like growth factor-1 (IGF-1) was loaded on the coating material alginate, its release from alginate into the medium presented in a time-dependent and pH-dependent way.	Alginates	77-85	insulin like growth factor 1	Homo sapiens	35-40
25347385-5	2015	When insulin-like growth factor-1 (IGF-1) was loaded on the coating material alginate, its release from alginate into the medium presented in a time-dependent and pH-dependent way.	Alginates	104-112	insulin like growth factor 1	Homo sapiens	5-33
25347385-5	2015	When insulin-like growth factor-1 (IGF-1) was loaded on the coating material alginate, its release from alginate into the medium presented in a time-dependent and pH-dependent way.	Alginates	104-112	insulin like growth factor 1	Homo sapiens	35-40
25541639-6	2015	Due to the alginate components in the composites, the scaffolds showed significantly enhanced wetting behavior, water-absorption (~12-fold), and meaningful biological activities (~2.1-fold for cell-seeding efficiency, ~2.5-fold for cell-viability at 7 days, ~3.4-fold for calcium deposition), compared with a pure PCL scaffold.	Alginates	11-19	PHD finger protein 1	Homo sapiens	314-317
24564349-0	2015	Fibronectin-Alginate microcapsules improve cell   viability and protein secretion of encapsulated   Factor IX-engineered human mesenchymal   stromal cells.	Alginates	12-20	fibronectin 1	Homo sapiens	0-11
25785047-1	2015	OBJECTIVES: In order to investigate the encapsulation of interleukin 1 receptor antagonist (IL-RA) gene-modified mesenchymal stem cells (MSCs) in alginate-poly-L-lysine (APA) microcapsules for the persistent delivery of interleukin 1 receptor antagonist (IL-RA) to treat Rheumatoid arthritis (RA).	Alginates	146-154	interleukin 1 receptor antagonist	Rattus norvegicus	57-90
25785047-1	2015	OBJECTIVES: In order to investigate the encapsulation of interleukin 1 receptor antagonist (IL-RA) gene-modified mesenchymal stem cells (MSCs) in alginate-poly-L-lysine (APA) microcapsules for the persistent delivery of interleukin 1 receptor antagonist (IL-RA) to treat Rheumatoid arthritis (RA).	Alginates	146-154	interleukin 1 receptor antagonist	Rattus norvegicus	92-97
26656812-0	2015	Electroactive Film of Myoglobin Incorporated in a 3D-porous Calcium Alginate Film with Polyvinyl Alcohol, Glycerin and Gelatin.	Alginates	60-76	myoglobin	Homo sapiens	22-31
26656812-1	2015	In this work, an electroactive porous Mb-CA"s composite film was fabricated by incorporating myoglobin (Mb) in a three-dimension (3D) porous calcium alginate (CA) film with polyvinyl alcohol, glycerol, and gelatin.	Alginates	141-157	myoglobin	Homo sapiens	38-40
24564349-7	2015	Differentiation studies demonstrated osteogenic (but not chondrogenic or adipogenic) differentiation capability and efficient FIX secretion of the enclosed MSCs in the fibronectin-alginate suspension culture.	Alginates	180-188	fibronectin 1	Homo sapiens	168-179
24564349-8	2015	Thus, the use of recombinant MSCs encapsulated in fibronectin-alginate microcapsules in basal or osteogenic cultures may be of practical use in the treatment of hemophilia B.	Alginates	62-70	fibronectin 1	Homo sapiens	50-61
24833283-0	2015	Preparation and optical properties of alloyed Znx Cd1-x S/alginate core/shell nanoparticles.	Alginates	58-66	CD1c molecule	Homo sapiens	50-53
24833283-4	2015	The band gap of Znx Cd1-x S/alginate core/shell nanoparticles increases with increasing Zn/Cd molar ratio, and the UV/vis absorption blue-shifts correspondingly.	Alginates	28-36	CD1c molecule	Homo sapiens	20-23
24833283-5	2015	Two emissions related to zinc and sulfide ion vacancies were observed for the Znx Cd1-x S/alginate core/shell nanoparticles due to the surface changes from the alginate coating.	Alginates	90-98	CD1c molecule	Homo sapiens	82-85
24833283-5	2015	Two emissions related to zinc and sulfide ion vacancies were observed for the Znx Cd1-x S/alginate core/shell nanoparticles due to the surface changes from the alginate coating.	Alginates	160-168	CD1c molecule	Homo sapiens	82-85
24833283-6	2015	A cadmium-related emission was observed for both the uncovered Znx Cd1-x S and Znx Cd1-x S/alginate core/shell nanoparticles, which has a significant blue-shift with increasing Zn/Cd molar ratio.	Alginates	91-99	CD1c molecule	Homo sapiens	83-86
25785047-1	2015	OBJECTIVES: In order to investigate the encapsulation of interleukin 1 receptor antagonist (IL-RA) gene-modified mesenchymal stem cells (MSCs) in alginate-poly-L-lysine (APA) microcapsules for the persistent delivery of interleukin 1 receptor antagonist (IL-RA) to treat Rheumatoid arthritis (RA).	Alginates	146-154	interleukin 1 receptor antagonist	Rattus norvegicus	57-97
24564349-0	2015	Fibronectin-Alginate microcapsules improve cell   viability and protein secretion of encapsulated   Factor IX-engineered human mesenchymal   stromal cells.	Alginates	12-20	coagulation factor IX	Homo sapiens	100-109
24564349-3	2015	In this study we hypoth-esize that the presence of fibronectin in an alginate matrix may enhance the viability and functionality of encapsulated human cord blood-derived mesenchymal stromal cells (MSCs) expressing the human Factor IX (FIX) gene.	Alginates	69-77	fibronectin 1	Homo sapiens	51-62
24564349-3	2015	In this study we hypoth-esize that the presence of fibronectin in an alginate matrix may enhance the viability and functionality of encapsulated human cord blood-derived mesenchymal stromal cells (MSCs) expressing the human Factor IX (FIX) gene.	Alginates	69-77	coagulation factor IX	Homo sapiens	224-233
24564349-4	2015	MSCs were encapsulated in alginate-PLL microcapsules containing 10, 100, or 500 mug/ml fibronectin to ameliorate cell survival.	Alginates	26-34	fibronectin 1	Homo sapiens	87-98
25890746-4	2015	Human hepatoma cell line HepG2 cells were selectively encapsulated in alginate-based hydrogel sheath from the mixture with mouse embryo fibroblast-like cell line 10T1/2 fibroblasts using anti-human CD326 antibody conjugated with HRP.	Alginates	70-78	epithelial cell adhesion molecule	Mus musculus	198-203
25890751-3	2015	In this study, we generated an alginate microsphere (named PaLtTcAdMIP3alpha) that encapsulated tumor lysates, live tumor cells engineering with a recombinant MIP-3alpha adenovirus and BCG.	Alginates	31-39	chemokine (C-C motif) ligand 20	Mus musculus	159-169
25379652-3	2015	Recently, several marine polysaccharides such alginate, porphyran, fucoidan, and chitin and its derivatives have been evidenced as downregulators of allergic responses due to enhancement of innate immune system, alteration of Th1/Th2 balance forward to Th1 cells, inhibition of IgE production, and suppression of mast cell degranulation.	Alginates	46-54	negative elongation factor complex member C/D	Homo sapiens	253-256
25967960-7	2015	RESULTS: The combination of sodium alginate and resveratrol significantly reduced synovial levels of IL-1beta, CCR5, and CXCL10 when compared with colchicines, and all P values were less than 0.0001.	Alginates	28-43	interleukin 1 beta	Mus musculus	101-109
25967960-7	2015	RESULTS: The combination of sodium alginate and resveratrol significantly reduced synovial levels of IL-1beta, CCR5, and CXCL10 when compared with colchicines, and all P values were less than 0.0001.	Alginates	28-43	chemokine (C-C motif) receptor 5	Mus musculus	111-115
25967960-7	2015	RESULTS: The combination of sodium alginate and resveratrol significantly reduced synovial levels of IL-1beta, CCR5, and CXCL10 when compared with colchicines, and all P values were less than 0.0001.	Alginates	28-43	chemokine (C-X-C motif) ligand 10	Mus musculus	121-127
25967960-8	2015	The combination of sodium alginate and resveratrol was also superior to resveratrol in terms of both serum levels and synovial levels of IL-1beta, CCR5, and CXCL10.	Alginates	19-34	interleukin 1 beta	Mus musculus	137-145
25967960-8	2015	The combination of sodium alginate and resveratrol was also superior to resveratrol in terms of both serum levels and synovial levels of IL-1beta, CCR5, and CXCL10.	Alginates	19-34	chemokine (C-C motif) receptor 5	Mus musculus	147-151
25967960-8	2015	The combination of sodium alginate and resveratrol was also superior to resveratrol in terms of both serum levels and synovial levels of IL-1beta, CCR5, and CXCL10.	Alginates	19-34	chemokine (C-X-C motif) ligand 10	Mus musculus	157-163
25967960-9	2015	In addition, resveratrol, with or without sodium alginate, could reduce NLRP3 expression obviously in the synovial tissues.	Alginates	42-57	NLR family, pyrin domain containing 3	Mus musculus	72-77
25239194-5	2015	Significant hypoglycemic effects with improved insulin-relative bioavailability (~ 8.11%) in in vivo model revealed the efficacy of these core-shell nanoparticles of CS/ALG as an oral insulin carrier.	Alginates	169-172	insulin	Homo sapiens	184-191
25661399-6	2015	Further study shows that fabrication of alginate-HA gels with PEI increases the encapsulation efficiency of bovine serum albumin, a model protein, and reduces the subsequent initial protein release rate.	Alginates	40-48	albumin	Mus musculus	115-128
25802761-1	2015	The aim of the present study was to formulate and investigate the calcium alginate- (CA-) Neusilin US2 nanocomposite microbeads containing preconcentrate of aceclofenac sodium (ACF-Na) liquid microemulsion (L-ME) for enhancement of oral bioavailability.	Alginates	66-82	usherin	Homo sapiens	99-102
25379652-3	2015	Recently, several marine polysaccharides such alginate, porphyran, fucoidan, and chitin and its derivatives have been evidenced as downregulators of allergic responses due to enhancement of innate immune system, alteration of Th1/Th2 balance forward to Th1 cells, inhibition of IgE production, and suppression of mast cell degranulation.	Alginates	46-54	negative elongation factor complex member C/D	Homo sapiens	226-229
25478165-4	2014	The bioorthogonal Staudinger ligation scheme was used to chemoselectively crosslink azide functionalized hyperbranched alginate (alginate-hN3) to methyl-2-diphenylphosphino-terephthalate (MDT) linked PAMAM dendrimer (PAMAM-MDT).	Alginates	119-127	MT-RNR2 like 3 (pseudogene)	Homo sapiens	138-141
25478165-5	2014	Covalent layer-by-layer deposition of PAMAM-MDT/alginate-hN3 coatings onto alginate microbeads resulted in highly stable coatings, even after the inner alginate gel was liquefied to form microcapsules.	Alginates	48-56	MT-RNR2 like 3 (pseudogene)	Homo sapiens	57-60
25478165-5	2014	Covalent layer-by-layer deposition of PAMAM-MDT/alginate-hN3 coatings onto alginate microbeads resulted in highly stable coatings, even after the inner alginate gel was liquefied to form microcapsules.	Alginates	75-83	MT-RNR2 like 3 (pseudogene)	Homo sapiens	57-60
25478165-5	2014	Covalent layer-by-layer deposition of PAMAM-MDT/alginate-hN3 coatings onto alginate microbeads resulted in highly stable coatings, even after the inner alginate gel was liquefied to form microcapsules.	Alginates	75-83	MT-RNR2 like 3 (pseudogene)	Homo sapiens	57-60
25478165-7	2014	The cytocompatibility of the resulting PAMAM-MDT/alginate-hN3 coating was evaluated using a beta cell line, with no significant detrimental response observed.	Alginates	49-57	MT-RNR2 like 3 (pseudogene)	Homo sapiens	58-61
24677739-1	2014	Despite the widespread use of alginate (AL) hydrogels in many biomedical applications, including tissue engineering, AL is inherently non-degradable under physiological conditions.	Alginates	30-38	dal	Drosophila melanogaster	117-119
24677739-1	2014	Despite the widespread use of alginate (AL) hydrogels in many biomedical applications, including tissue engineering, AL is inherently non-degradable under physiological conditions.	Alginates	30-38	dal	Drosophila melanogaster	40-42
25503160-1	2014	We have previously reported that polaprezinc in sodium alginate suspension (P-AG) inhibited the incidence of oral mucositis induced by radiochemotherapy in patients with head and neck cancer.	Alginates	48-63	phosphoprotein membrane anchor with glycosphingolipid microdomains 1	Homo sapiens	76-80
24996322-0	2014	Drying process of sodium alginate films studied by two-dimensional correlation ATR-FTIR spectroscopy.	Alginates	18-33	ATR serine/threonine kinase	Homo sapiens	79-82
24996322-1	2014	Drying process of aqueous sodium alginate solutions at 50 C was investigated by ATR-FTIR spectroscopy and two-dimensional correlation infrared spectroscopy.	Alginates	26-41	ATR serine/threonine kinase	Homo sapiens	80-83
24677739-2	2014	We hypothesized that degradable alginate (dAL) would be useful for cartilage regeneration when combined with hyaluronate (HA).	Alginates	32-40	dal	Drosophila melanogaster	42-45
22042457-4	2014	The honey-alginate scaffold demonstrates better performance than that of alginate in terms of cellular adherence, viability and proper expression of cell-cell adhesion molecule (E-cadherin) and prime molecules of extra cellular matrix (Collagen I and III) by HaCaT and 3T3 respectively.	Alginates	10-18	cadherin 1	Homo sapiens	178-188
25308839-1	2014	A novel wound-dressing biodevice, sensitive to lysozyme, an enzyme commonly found at infected skin wounds, was assembled by the layer-by-layer deposition of nanopolymeric chitosan and alginate films onto oxidized bacterial cellulose membranes incorporated with epidermal growth factor (EGF).	Alginates	184-192	lysozyme	Homo sapiens	47-55
25308839-3	2014	In in vitro conditions simulating noninfected wounds, the EGF rate and burst release effect were reduced by three deposited layers (Mt /M  of 0.25 at 3 h) in a process dependent on the porosity of the compact chitosan-alginate complex.	Alginates	218-226	epidermal growth factor	Homo sapiens	58-61
25705097-9	2014	Increasing the guluronate content of the alginate microbead increased IGF-I retention.	Alginates	41-49	insulin like growth factor 1	Homo sapiens	70-75
24881778-7	2014	More striking was that alginate encapsulation resulted in a much stronger differentiation compared to parallel two-dimensional cultures, resulting in 20-fold increase in c-peptide protein synthesis.	Alginates	23-31	insulin	Homo sapiens	170-179
25239278-11	2014	Insulin secretion was higher with islets embedded in fibrin and alginate when compared to non-encapsulated islets.	Alginates	64-72	insulin	Homo sapiens	0-7
25194780-7	2014	When hep-FDM-bound VEGF (H-F/V) was encapsulated into alginate capsules (A/H-F/V) and subjected to release test for 28 days, it exhibited a significantly reduced burst release at early time point compared to that of A/V.	Alginates	54-62	vascular endothelial growth factor A	Homo sapiens	19-23
25705097-10	2014	Decreasing alginate molecular weight eliminated the effects microencapsulation had on increasing IGF-I secretion.	Alginates	11-19	insulin like growth factor 1	Homo sapiens	97-102
25129795-1	2014	This article focuses on the development of eco-friendly adsorbent by alginate (Alg) bioencapsulating nano-hydroxyapatite (n-HAp) namely n-HApAlg composite for defluoridation studies in batch mode.	Alginates	69-77	reticulon 3	Homo sapiens	124-127
25129795-1	2014	This article focuses on the development of eco-friendly adsorbent by alginate (Alg) bioencapsulating nano-hydroxyapatite (n-HAp) namely n-HApAlg composite for defluoridation studies in batch mode.	Alginates	79-82	reticulon 3	Homo sapiens	124-127
25234602-10	2014	Confocal immunofluorescence demonstrated that MSCs survive and are associated with expression of connexin-43 (Cx43) for either PBS (control), 1%, or 2% alginate.	Alginates	152-160	gap junction protein alpha 1	Sus scrofa	97-108
25309741-4	2014	We use a Mixing-Induced Two-Component Hydrogel (MITCH) embedded with alginate microgels to deliver two pro-adipogenic soluble factors, fibroblast growth factor 1 (FGF-1) and bone morphogenetic protein 4 (BMP-4) with two distinct delivery profiles.	Alginates	69-77	fibroblast growth factor 1	Homo sapiens	135-161
25309741-4	2014	We use a Mixing-Induced Two-Component Hydrogel (MITCH) embedded with alginate microgels to deliver two pro-adipogenic soluble factors, fibroblast growth factor 1 (FGF-1) and bone morphogenetic protein 4 (BMP-4) with two distinct delivery profiles.	Alginates	69-77	bone morphogenetic protein 4	Homo sapiens	174-202
25466464-1	2014	The present work aimed at studying the interaction between insulin and SiNP surfaced with mucoadhesive polymers (chitosan, sodium alginate or polyethylene glycol) and the evaluation of their biocompatibility with HepG2 and Caco-2 cell lines, which mimic in vivo the target of insulin-loaded nanoparticles upon oral administration.	Alginates	123-138	insulin	Homo sapiens	59-66
25027303-4	2014	Laponite/mafenide/alginate (Lap/Maf/Alg) film was also formulated by combining Lap/Maf gel (1:1) with alginate.	Alginates	102-110	LAP	Homo sapiens	0-3
25234602-10	2014	Confocal immunofluorescence demonstrated that MSCs survive and are associated with expression of connexin-43 (Cx43) for either PBS (control), 1%, or 2% alginate.	Alginates	152-160	gap junction protein alpha 1	Sus scrofa	110-114
24937137-6	2014	Alginate/bECM hydrogels loaded with HSA/VEGF or HSA/TGF-beta3 demonstrated a cartilage-like phenotype, with minimal collagen I deposition, comparable to HSA-only control hydrogels.	Alginates	0-8	vascular endothelial growth factor A	Gallus gallus	40-44
32261879-7	2014	In addition, cell-laden alginate struts (200 and 800 mum) were used to fabricate poly(epsilon-caprolactone) hybrid scaffolds; the hybrid scaffolds were interlayered with a cell-laden hydrogel (200 mum), demonstrating significantly high osteogenic expression compared to scaffolds laden with 800 mum struts.	Alginates	24-32	latexin	Homo sapiens	53-56
24954001-0	2014	Oxidized alginate hydrogels for bone morphogenetic protein-2 delivery in long bone defects.	Alginates	9-17	bone morphogenetic protein 2	Homo sapiens	32-60
24954001-3	2014	Irradiated RGD-alginate hydrogels have been used to deliver proteins such as bone morphogenetic protein-2 (BMP-2), to promote bone regeneration and restoration of function in a critically sized rat femoral defect model.	Alginates	15-23	bone morphogenetic protein 2	Rattus norvegicus	77-105
24954001-3	2014	Irradiated RGD-alginate hydrogels have been used to deliver proteins such as bone morphogenetic protein-2 (BMP-2), to promote bone regeneration and restoration of function in a critically sized rat femoral defect model.	Alginates	15-23	bone morphogenetic protein 2	Rattus norvegicus	107-112
24954001-6	2014	The objective of this study was to evaluate the effects of alginate oxidation on BMP-2 release and bone regeneration.	Alginates	59-67	bone morphogenetic protein 2	Homo sapiens	81-86
24954001-7	2014	We hypothesized that oxidized-irradiated alginate hydrogels would elicit an accelerated release of BMP-2, but degrade faster in vivo, facilitating the formation of higher quality, more mature bone compared to irradiated alginate.	Alginates	41-49	bone morphogenetic protein 2	Homo sapiens	99-104
24979209-3	2014	The goal of this study was to design and fabricate ligand-conjugated alginate-graft-poly(ethylene glycol) microspheres for intracellular delivery and release of VEGFA in primary human MSCs to enhance osteogenic differentiation as a potential therapeutic.	Alginates	69-77	vascular endothelial growth factor A	Homo sapiens	161-166
25310111-0	2014	Alginate hydrogel protects encapsulated hepatic HuH-7 cells against hepatitis C virus and other viral infections.	Alginates	0-8	MIR7-3 host gene	Homo sapiens	48-53
25310111-3	2014	The aim of this work is to investigate the potential protective effect of alginate encapsulation against hepatitis C virus (HCV) infection for a hepatic cell line (HuH-7) normally permissive to the virus.	Alginates	74-82	MIR7-3 host gene	Homo sapiens	164-169
25310111-4	2014	Our results showed that alginate hydrogel protects HuH-7 cells against HCV when the supernatant was loaded with HCV.	Alginates	24-32	MIR7-3 host gene	Homo sapiens	51-56
25310111-5	2014	In addition, alginate hydrogel blocked HCV particle release out of the beads when the HuH-7 cells were previously infected and encapsulated.	Alginates	13-21	MIR7-3 host gene	Homo sapiens	86-91
24937137-6	2014	Alginate/bECM hydrogels loaded with HSA/VEGF or HSA/TGF-beta3 demonstrated a cartilage-like phenotype, with minimal collagen I deposition, comparable to HSA-only control hydrogels.	Alginates	0-8	transforming growth factor beta 3	Gallus gallus	52-61
24604430-8	2014	CONCLUSION: Dipping in sodium acetate (10 g L-1), coating with sodium alginate (40 g L-1) and packaging under MAP (0:75 O2:CO2) represent the best conditions to guarantee a significant shelf life extension to about 160 h compared with 57 h for unpackaged oysters.	Alginates	63-78	immunoglobulin kappa variable 1-16	Homo sapiens	85-88
30011632-1	2014	The aim of this work was to investigate the possibility of producing microparticles containing beta-galactosidase, using different biopolymers (arabic gum, chitosan, modified chitosan, calcium alginate and sodium alginate) as encapsulating agents by a spray-drying process.	Alginates	185-201	galactosidase beta 1	Homo sapiens	95-113
30011632-1	2014	The aim of this work was to investigate the possibility of producing microparticles containing beta-galactosidase, using different biopolymers (arabic gum, chitosan, modified chitosan, calcium alginate and sodium alginate) as encapsulating agents by a spray-drying process.	Alginates	206-221	galactosidase beta 1	Homo sapiens	95-113
25079431-5	2014	The blank ODF composed of Kollicoat( ) IR, sodium alginate (ALG-Na) and glycerol (10:2:1.5, w/w) had a remarkably short disintegration time of about 20s.	Alginates	43-58	outer dense fiber of sperm tails 1	Homo sapiens	10-13
25079431-5	2014	The blank ODF composed of Kollicoat( ) IR, sodium alginate (ALG-Na) and glycerol (10:2:1.5, w/w) had a remarkably short disintegration time of about 20s.	Alginates	60-66	outer dense fiber of sperm tails 1	Homo sapiens	10-13
25089506-1	2014	Photosensitizer-encapsulated amphiphilic sodium alginate derivative (Photosan-CSAD) nanoparticles were prepared because of their ability to enhance phototoxicity in the photodynamic therapy of pancreatic cancer.	Alginates	41-56	cysteine sulfinic acid decarboxylase	Homo sapiens	78-82
24954001-8	2014	Indeed, oxidation of irradiated alginate did accelerate in vitro BMP-2 release.	Alginates	32-40	bone morphogenetic protein 2	Homo sapiens	65-70
25113823-1	2014	Sodium alginate (SA), acting as a trypsin inhibitor by means of electrostatic interaction, is studied.	Alginates	0-15	kunitz trypsin protease inhibitor	Glycine max	34-51
25113823-1	2014	Sodium alginate (SA), acting as a trypsin inhibitor by means of electrostatic interaction, is studied.	Alginates	17-19	kunitz trypsin protease inhibitor	Glycine max	34-51
23795723-0	2014	Comparison of some biochemical properties of artichoke polyphenol oxidase entrapped in alginate-carrageenan and alginate gels.	Alginates	87-95	protoporphyrinogen oxidase	Homo sapiens	55-73
23795723-1	2014	Polyphenol oxidase (PPO, EC.1.14.18.1) isolated from artichoke (Cynara scolymus) was entrapped within alginate and alginate+ carrageenan beads, and the catecholase and cresolase activities of both entrapped enzymes were determined.	Alginates	102-110	protoporphyrinogen oxidase	Homo sapiens	0-18
23795723-1	2014	Polyphenol oxidase (PPO, EC.1.14.18.1) isolated from artichoke (Cynara scolymus) was entrapped within alginate and alginate+ carrageenan beads, and the catecholase and cresolase activities of both entrapped enzymes were determined.	Alginates	102-110	protoporphyrinogen oxidase	Homo sapiens	20-23
23795723-1	2014	Polyphenol oxidase (PPO, EC.1.14.18.1) isolated from artichoke (Cynara scolymus) was entrapped within alginate and alginate+ carrageenan beads, and the catecholase and cresolase activities of both entrapped enzymes were determined.	Alginates	115-123	protoporphyrinogen oxidase	Homo sapiens	0-18
23795723-1	2014	Polyphenol oxidase (PPO, EC.1.14.18.1) isolated from artichoke (Cynara scolymus) was entrapped within alginate and alginate+ carrageenan beads, and the catecholase and cresolase activities of both entrapped enzymes were determined.	Alginates	115-123	protoporphyrinogen oxidase	Homo sapiens	20-23
24933511-2	2014	In this study, the therapeutic potentials of 100% iron saturated-bovine lactoferrin encapsulated in alginate-chitosan polymeric nanocarriers (AEC-CP-Fe-bLf-NCs) were examined in in vitro inflammatory OA model and in collagen-induced arthritis (CIA) mice.	Alginates	100-108	lactotransferrin	Bos taurus	72-83
24913916-0	2014	Overexpression of CupB5 activates alginate overproduction in Pseudomonas aeruginosa by a novel AlgW-dependent mechanism.	Alginates	34-42	adhesive protein CupB5	Pseudomonas aeruginosa PAO1	18-23
25084008-0	2014	Enhanced healing of rat calvarial defects with MSCs loaded on BMP-2 releasing chitosan/alginate/hydroxyapatite scaffolds.	Alginates	87-95	bone morphogenetic protein 2	Rattus norvegicus	62-67
25084008-1	2014	In this study, we designed a chitosan/alginate/hydroxyapatite scaffold as a carrier for recombinant BMP-2 (CAH/B2), and evaluated the release kinetics of BMP-2.	Alginates	38-46	bone morphogenetic protein 2	Rattus norvegicus	100-105
24844124-6	2014	These sulfated alginates were shown to bind and displace HGF from the surface of myeloma cells in a manner similar to heparin.	Alginates	15-24	hepatocyte growth factor	Homo sapiens	57-60
24813329-7	2014	In contrast, cells encapsulated in pure alginate and in RGD-modified alginate formed spherical aggregates with limited cell mobility and VEGF secretion.	Alginates	69-77	vascular endothelial growth factor A	Homo sapiens	137-141
23946111-8	2014	The local delivery of VEGF by injectable alginate:fibrinogen-based hydrogel induced some plasticity in the injured spinal cord involving fiber growth into the lesion site.	Alginates	41-49	vascular endothelial growth factor A	Rattus norvegicus	22-26
24788192-4	2014	MATERIALS AND METHODS: The fabrication procedure for obtaining PCL/alginate/hUCS was performed.	Alginates	67-75	PHD finger protein 1	Homo sapiens	63-66
22733683-0	2014	Repair of an osteochondral defect by sustained delivery of BMP-2 or TGFbeta1 from a bilayered alginate-PLGA scaffold.	Alginates	94-102	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	68-76
24769910-2	2014	Here, we show that the delivery of vascular endothelial growth factor (VEGF) from alginate hydrogels ameliorates loss of skeletal muscle innervation after ischemic injury by promoting both maintenance and regrowth of damaged axons in mice.	Alginates	82-90	vascular endothelial growth factor A	Mus musculus	35-69
24769910-2	2014	Here, we show that the delivery of vascular endothelial growth factor (VEGF) from alginate hydrogels ameliorates loss of skeletal muscle innervation after ischemic injury by promoting both maintenance and regrowth of damaged axons in mice.	Alginates	82-90	vascular endothelial growth factor A	Mus musculus	71-75
24631250-5	2014	Gene expression analysis showed that cells grown in alginate and alginate-HA present increased differentiation toward neural lineages with respect to the two-dimensional control and to Fn group.	Alginates	52-60	fibronectin 1	Mus musculus	185-187
24657988-0	2014	Manufacture of beta-TCP/alginate scaffolds through a Fab@home model for application in bone tissue engineering.	Alginates	24-32	FA complementation group B	Homo sapiens	53-56
24657988-3	2014	In this study, we report for the first time the use of a Fab@home plotter for the production of 3D scaffolds composed by beta-tricalcium phosphate (beta-TCP)/alginate hybrid materials.	Alginates	158-166	FA complementation group B	Homo sapiens	57-60
24657988-11	2014	Altogether, our findings suggest that the Fab@home printer can be employed in the manufacture of reproducible scaffolds, using a formulation 50/50 alginate-beta-TCP that has suitable properties to be applied as bone substitutes in the future.	Alginates	147-155	FA complementation group B	Homo sapiens	42-45
24658021-4	2014	Encapsulated alginate hydrogel/thermoplastic polycaprolactone (Alg-PCL) cofibre scaffolds were fabricated.	Alginates	13-21	polycystic kidney disease 2-like 1	Mus musculus	67-70
24920887-11	2014	Long-term treatment of the ischemic rats with Hsp70 formulated in alginate granules with retarded release of protein further reduced the infarct volume in the brain as well as apoptotic area (annexin V staining).	Alginates	66-74	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	46-51
24876775-4	2014	For in vitro experiments, a pro-oxidant H2O2 or an inflammatory cytokine interleukin (IL)-1beta was employed to induce degenerated phenotypes in human nucleus pulposus cells encapsulated in alginate beads, and fullerol was added in the culture medium.	Alginates	190-198	interleukin 1 beta	Homo sapiens	73-95
24728760-4	2014	In an alginate/PEO sample that contains 20 % polyoxyethylene, we obtained a stable hydrogel for cell culture experiments.	Alginates	6-14	twinkle mtDNA helicase	Homo sapiens	15-18
24745551-3	2014	In this system, biocompatible polyelectrolyte multilayers of alginate/chitosan were assembled on MSN"s surface to achieve pH-responsive nanocarriers.	Alginates	61-69	moesin	Homo sapiens	97-100
24940057-2	2014	MSN@Alg microspheres have the advantages of MSN and alginate, where MSN provides a large surface area for high drug loading and alginate provides excellent biocompatibility and COOH functionality for specific targeting.	Alginates	52-60	moesin	Homo sapiens	0-3
24940057-2	2014	MSN@Alg microspheres have the advantages of MSN and alginate, where MSN provides a large surface area for high drug loading and alginate provides excellent biocompatibility and COOH functionality for specific targeting.	Alginates	128-136	moesin	Homo sapiens	0-3
24515547-1	2014	Alginate hydrogels functionalized with D-, or L-penicillamine (D-, L-PEN-Alg) are used as new 3D scaffolds for cell adhesion studies.	Alginates	0-8	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	69-72
24515547-3	2014	C-6-glioma and endothelial cells show higher affinity to the D-PEN than to the L-PEN functionalized 3D alginate hydrogel scaffold.	Alginates	103-111	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	81-84
24565522-0	2014	Cisplatin-alginate conjugate liposomes for targeted delivery to EGFR-positive ovarian cancer cells.	Alginates	10-18	epidermal growth factor receptor	Homo sapiens	64-68
24631250-5	2014	Gene expression analysis showed that cells grown in alginate and alginate-HA present increased differentiation toward neural lineages with respect to the two-dimensional control and to Fn group.	Alginates	65-73	fibronectin 1	Mus musculus	185-187
28788557-14	2014	We demonstrate that this alginate was immunostimulatory, even after purification due to reintroduction of the TLR5 activating flagellin.	Alginates	25-33	toll like receptor 5	Homo sapiens	110-114
24600027-8	2014	Furthermore, expression of alg8 is shown to be influenced by spf, suggesting that this ncRNA plays a role in alginate biosynthesis.	Alginates	109-117	ssrA	Pseudomonas syringae pv. tomato str. DC3000	87-92
23802745-0	2014	Cell-matrix Interactions of Factor IX (FIX)-engineered human mesenchymal stromal cells encapsulated in RGD-alginate vs. fibrinogen-alginate microcapsules.	Alginates	107-115	coagulation factor IX	Homo sapiens	28-37
24524580-3	2014	When dispersed in phosphate buffered saline media containing alginate or BSA, monodisperse spherical MSNs interact with linear biopolymers such as alginate and with a globular protein such as bovine serum albumin (BSA) independently of the surface charge sign (i.e. positive or negative), thus leading to a decrease in the surface energy and to the colloidal stabilization of these nanoparticles.	Alginates	61-69	albumin	Homo sapiens	199-212
24667749-9	2014	Insulin peaks at 30 min were lower by 46% after 2.5% alginate CM relative to CM (95% CIs: 3.49-31.78; P=0.009).	Alginates	53-61	insulin	Homo sapiens	0-7
24681880-1	2014	OBJECTIVE: Our study aim was to determine encapsulated islet graft viability in an omentum pouch and the effect of fibroblast growth factor 1 (FGF-1) released from our redesigned alginate microcapsules on the function of the graft.	Alginates	179-187	fibroblast growth factor 1	Rattus norvegicus	115-141
24681880-1	2014	OBJECTIVE: Our study aim was to determine encapsulated islet graft viability in an omentum pouch and the effect of fibroblast growth factor 1 (FGF-1) released from our redesigned alginate microcapsules on the function of the graft.	Alginates	179-187	fibroblast growth factor 1	Rattus norvegicus	143-148
24320935-7	2014	Sulfated alginate increased the RhoA activity of chondrocytes compared with unmodified alginate, an increase that was blocked by beta1 blocking antibodies (p=0.017).	Alginates	9-17	ras homolog family member A	Bos taurus	32-36
24123995-3	2014	A parylene microplate array of 10-70 mum in diameter can be formed on an alginate hydrogel sacrificial layer by using a standard photolithographic process.	Alginates	73-81	latexin	Homo sapiens	37-40
24467335-6	2014	The shape memory porous scaffold loaded with bone morphogenetic protein-2 (BMP-2) was also fabricated by coating the calcium alginate layer and BMP-2 on the surface of the pore wall.	Alginates	117-133	bone morphogenetic protein 2	Oryctolagus cuniculus	45-73
24467335-6	2014	The shape memory porous scaffold loaded with bone morphogenetic protein-2 (BMP-2) was also fabricated by coating the calcium alginate layer and BMP-2 on the surface of the pore wall.	Alginates	117-133	bone morphogenetic protein 2	Oryctolagus cuniculus	75-80
23873758-5	2014	Human chondrocytes were encapsulated in three-dimensional (3D) alginate beads where they exhibited upregulated COL2A1 mRNA expression and increased levels of SirT1 occupancy on the promoter and enhancer regions, when compared to monolayer controls.	Alginates	63-71	collagen type II alpha 1 chain	Homo sapiens	111-117
24627600-7	2014	RESULTS: AL-Na significantly reduced indomethacin-induced ulcer size and myeloperoxidase activity in the stomach and small intestine.	Alginates	9-14	myeloperoxidase	Rattus norvegicus	73-88
24627600-8	2014	AL-Na prevented increases in microvascular permeability, superoxide dismutase content, glutathione peroxidase activity and catalase activity in small intestinal injury induced by indomethacin.	Alginates	0-5	catalase	Rattus norvegicus	123-131
24627600-10	2014	Moreover, AL-Na suppressed mucin depletion by indomethacin and inhibited infiltration of enterobacteria into the small intestine.	Alginates	10-15	solute carrier family 13 member 2	Rattus norvegicus	27-32
24400664-3	2014	Peptide mimics of bone morphogenetic protein 2 (BMP-2) were synthesized by solid phase Fmoc-peptide synthesis and covalently bound to alginate hydrogels via either carbodiimide or sulfhydryl-based coupling strategies.	Alginates	134-142	bone morphogenetic protein 2	Mus musculus	18-46
24400664-3	2014	Peptide mimics of bone morphogenetic protein 2 (BMP-2) were synthesized by solid phase Fmoc-peptide synthesis and covalently bound to alginate hydrogels via either carbodiimide or sulfhydryl-based coupling strategies.	Alginates	134-142	bone morphogenetic protein 2	Mus musculus	48-53
24400664-5	2014	Peptides derived from the knuckle epitope of BMP-2, presented from both 2D surfaces and 3D alginate hydrogels, were shown to increase alkaline phosphatase activity in clonally derived murine osteoblasts.	Alginates	91-99	bone morphogenetic protein 2	Mus musculus	45-50
23997043-1	2014	This study reports the synthesis of mesoporous silica nanoparticle-encapsulated alginate microparticles (MSN@Alg) for sustained release and targeting therapy.	Alginates	80-88	moesin	Homo sapiens	105-108
23997043-2	2014	The MSN@Alg was synthesized by air dynamical atomization, and the effects of several critical factors including concentration of alginate solution, flow rate of alginate solution, flow rate of air, the distance between nozzle and calcium bath, and stirring rate of calcium on the particle size of the synthesized MSN@Alg were investigated.	Alginates	129-137	moesin	Homo sapiens	4-7
23997043-2	2014	The MSN@Alg was synthesized by air dynamical atomization, and the effects of several critical factors including concentration of alginate solution, flow rate of alginate solution, flow rate of air, the distance between nozzle and calcium bath, and stirring rate of calcium on the particle size of the synthesized MSN@Alg were investigated.	Alginates	161-169	moesin	Homo sapiens	4-7
24648725-8	2014	LMWP-TAZ was applied in alginate gel for the purpose of localization and controlled release.	Alginates	24-32	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	5-8
24648725-9	2014	The LMWP-TAZ fusion protein-loaded alginate gel matrix significantly increased bone formation in rabbit calvarial defects compared with alginate gel matrix mixed with free TAZ protein.	Alginates	35-43	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	9-12
24397989-4	2014	In the current study, a co-delivery system based on TGF-beta3-loaded RGD-coupled alginate microspheres was developed for encapsulating periodontal ligament stem cells (PDLSCs) or gingival mesenchymal stem cells (GMSCs).	Alginates	81-89	transforming growth factor beta 3	Homo sapiens	52-61
24397989-11	2014	PDLSCs and GMSCs encapsulated in TGF-beta3-loaded RGD-modified alginate microspheres are promising candidates for tendon regeneration.	Alginates	63-71	transforming growth factor beta 3	Homo sapiens	33-42
24115673-1	2014	In this study, we performed whole-genome complementation using a PAO1-derived cosmid library, coupled with in vitro transposon mutagenesis, to identify gene locus PA1494 as a novel inhibitor of alginate overproduction in P. aeruginosa strains possessing a wild-type mucA.	Alginates	194-202	hypothetical protein	Pseudomonas aeruginosa PAO1	163-169
24438897-11	2014	Microencapsulated VEGF gene-modified hUCMSCs were prepared with the use of a sodium alginate-barium chloride one-step encapsulation technology.	Alginates	77-92	vascular endothelial growth factor A	Sus scrofa	18-22
23873758-5	2014	Human chondrocytes were encapsulated in three-dimensional (3D) alginate beads where they exhibited upregulated COL2A1 mRNA expression and increased levels of SirT1 occupancy on the promoter and enhancer regions, when compared to monolayer controls.	Alginates	63-71	sirtuin 1	Homo sapiens	158-163
25300539-5	2014	Recently, several marine polysaccharides such alginate, porphyran, fucoidan, and chitin and its derivatives have been found as modulators of allergic responses due to enhancing innate immune system, altering Th1/Th2 balance, inhibiting IgE production, and suppressing mast cell degranulation.	Alginates	46-54	negative elongation factor complex member C/D	Homo sapiens	208-211
25081079-1	2014	To gain insight into the structure-activity relationship of alginate, we examined the effect of alginates with varying molecular weights and M/G ratio on murine macrophage cell line, RAW264.7 cells in terms of induction of tumor necrosis factor-alpha (TNF-alpha) secretion.	Alginates	96-105	tumor necrosis factor	Mus musculus	223-250
25076529-13	2014	Alginate enlarged the impact of CeO2 NPs to corn plants by reducing chlorophyll a content and triggering overexpression of heat shock protein 70.	Alginates	0-8	heat shock 70 kDa protein 4	Zea mays	123-144
24070211-8	2014	Further, results revealed that RGD-coupled alginate scaffold facilitated the differentiation of oral MSCs toward an osteoblast lineage in vitro and in vivo, as assessed by expression of osteogenic markers Runx2, ALP, and osteocalcin.	Alginates	43-51	runt related transcription factor 2	Mus musculus	205-210
24070211-8	2014	Further, results revealed that RGD-coupled alginate scaffold facilitated the differentiation of oral MSCs toward an osteoblast lineage in vitro and in vivo, as assessed by expression of osteogenic markers Runx2, ALP, and osteocalcin.	Alginates	43-51	alopecia, recessive	Mus musculus	212-215
24070211-8	2014	Further, results revealed that RGD-coupled alginate scaffold facilitated the differentiation of oral MSCs toward an osteoblast lineage in vitro and in vivo, as assessed by expression of osteogenic markers Runx2, ALP, and osteocalcin.	Alginates	43-51	bone gamma-carboxyglutamate protein 2	Mus musculus	221-232
24520214-3	2014	This study has investigated effects of VEGF-C/VEGFR-3 (vascular endothelial growth factor receptor-3) signaling pathway on EPC differentiation and effectiveness of inhibiting lymphatic formation of EPCs with VEGFR-3 siRNA delivered in PEI (polyethylenimine)-alginate nanoparticles.	Alginates	258-266	fms related receptor tyrosine kinase 4	Homo sapiens	208-215
24035886-3	2014	Here we demonstrate that the swelling behavior, degradation profiles, and storage moduli of crosslinked OMA/PEG hydrogels are tunable by varying the degree of alginate oxidation.	Alginates	159-167	progestagen associated endometrial protein	Homo sapiens	108-111
25081079-2	2014	Among the alginates tested, alginate with the highest molecular weight (MW 38,000, M/G 2.24) showed the most potent TNF-alpha-inducing activity.	Alginates	10-19	tumor necrosis factor	Mus musculus	116-125
25081079-2	2014	Among the alginates tested, alginate with the highest molecular weight (MW 38,000, M/G 2.24) showed the most potent TNF-alpha-inducing activity.	Alginates	10-18	tumor necrosis factor	Mus musculus	116-125
24379663-3	2014	Based on the principle of "like dissolves like", cholesterol, which shares the same steroidal parent nucleus with YC1, was selected to react with sodium alginate, producing amphiphilic sodium alginate- cholesterol derivatives (SACDs).	Alginates	146-161	RNA binding motif, single stranded interacting protein 1	Mus musculus	114-117
25081079-5	2014	Interestingly, enzymatic depolymerization of alginate with bacterial alginate lyase resulted in dramatic increase in the TNF-alpha-inducing activity.	Alginates	45-53	tumor necrosis factor	Mus musculus	121-130
24138828-9	2014	With the aim of increasing growth factor effectiveness in the context of disease, we examined whether local treatment with alginate gel-delivered FGF-2 and syndecan-4 proteoliposomes could overcome the growth factor resistance in these mice.	Alginates	123-131	fibroblast growth factor 2	Mus musculus	146-151
24696697-3	2014	EVIDENCE ACQUISITION: Recent reports have identified and explained the beneficial role of several structural molecules like mucoadhesive polymers (polyacrylic acid, sodium alginate, chitosan) and other copolymers for the efficient transport and release of insulin to its receptors.	Alginates	165-180	insulin	Homo sapiens	256-263
24696697-6	2014	Insulin nanoparticles formed by using alginate and dextran sulfate nucleating around calcium and binding to poloxamer, stabilized by chitosan, and subsequently coated with albumin showed a threefold increase of the hypoglycemic effect in comparison to free insulin in animal models.	Alginates	38-46	insulin	Homo sapiens	0-7
24379663-3	2014	Based on the principle of "like dissolves like", cholesterol, which shares the same steroidal parent nucleus with YC1, was selected to react with sodium alginate, producing amphiphilic sodium alginate- cholesterol derivatives (SACDs).	Alginates	185-200	RNA binding motif, single stranded interacting protein 1	Mus musculus	114-117
24268246-8	2014	Taken together, this study demonstrated that chondrocytes favored microcavitary alginate hydrogel with pore size within the range of 80-120mum for better growth and ECM synthesis, in which Erk1/2 pathway was involved.	Alginates	80-88	mitogen-activated protein kinase 3	Homo sapiens	189-195
23834314-4	2014	ALP, a model protein, was successfully encapsulated in the physically cross-linked sodium alginate/hydroxypropylcellulose (ALG-HPC) hydrogel microparticles.	Alginates	83-98	ATHS	Homo sapiens	0-3
24211233-9	2014	RESULTS: Treatment with WIN-55 alone or in combination with IL-1beta, decreased or abolished MMP-3, -13, TIMP-1 and -2 gene expression in human chondrocyte monolayer and alginate bead cultures in both a concentration and time dependent manner.	Alginates	170-178	interleukin 1 beta	Homo sapiens	60-68
24976683-5	2014	The ZNF521 mRNA instead was abundant in all primary chondrocytes studied; the RNAi-mediated silencing of this gene significantly altered the COL2A/COL1 expression ratio, associated with the maintenance of the differentiated phenotype, in chondrocytes cultivated in alginate beads.	Alginates	265-273	zinc finger protein 521	Homo sapiens	4-10
24211233-10	2014	WIN-55 treatment alone, and in combination with IL-1beta, reduced MMP-3 and -13 protein production by chondrocytes cultured in alginate beads.	Alginates	127-135	interleukin 1 beta	Homo sapiens	48-56
24211233-10	2014	WIN-55 treatment alone, and in combination with IL-1beta, reduced MMP-3 and -13 protein production by chondrocytes cultured in alginate beads.	Alginates	127-135	matrix metallopeptidase 3	Homo sapiens	66-79
23891740-4	2013	The objectives of this study were to: (1) develop a novel co-delivery system based on TGF-beta1 loaded RGD-coupled alginate microspheres encapsulating periodontal ligament stem cells (PDLSCs) or gingival mesenchymal stem cells (GMSCs); and (2) investigate dental MSC viability and chondrogenic differentiation in alginate microspheres.	Alginates	115-123	transforming growth factor beta 1	Homo sapiens	86-95
24051034-6	2013	By using cell-lines with a non-functional adaptor molecule essential in Toll-like receptor signaling, i.e. MyD88, we were able to show that alginates signal mainly via MyD88.	Alginates	140-149	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	107-112
24051034-6	2013	By using cell-lines with a non-functional adaptor molecule essential in Toll-like receptor signaling, i.e. MyD88, we were able to show that alginates signal mainly via MyD88.	Alginates	140-149	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	168-173
23891740-4	2013	The objectives of this study were to: (1) develop a novel co-delivery system based on TGF-beta1 loaded RGD-coupled alginate microspheres encapsulating periodontal ligament stem cells (PDLSCs) or gingival mesenchymal stem cells (GMSCs); and (2) investigate dental MSC viability and chondrogenic differentiation in alginate microspheres.	Alginates	313-321	transforming growth factor beta 1	Homo sapiens	86-95
23891740-5	2013	The results revealed the sustained release of TGF-beta1 from the alginate microspheres.	Alginates	65-73	transforming growth factor beta 1	Homo sapiens	46-55
23938198-3	2013	We found that dendritic cells (DCs) encapsulated in Ca(2+)-crosslinked alginate (calcium alginate) secreted at least fivefold more of the inflammatory cytokine IL-1beta when compared to DCs encapsulated in agarose and collagen gels, as well as DCs plated on tissue-culture polystyrene (TCPS).	Alginates	71-79	interleukin 1 beta	Homo sapiens	160-168
23938198-3	2013	We found that dendritic cells (DCs) encapsulated in Ca(2+)-crosslinked alginate (calcium alginate) secreted at least fivefold more of the inflammatory cytokine IL-1beta when compared to DCs encapsulated in agarose and collagen gels, as well as DCs plated on tissue-culture polystyrene (TCPS).	Alginates	81-97	interleukin 1 beta	Homo sapiens	160-168
23938198-6	2013	When injected subcutaneously in mice, calcium alginate gels significantly upregulated IL-1beta secretion from surrounding tissue relative to barium alginate gels, and similarly, the inflammatory effects of LPS were enhanced when it was delivered from calcium alginate gels rather than barium alginate gels.	Alginates	38-54	interleukin 1 beta	Mus musculus	86-94
24097945-2	2013	AlgR activates alginate production and twitching motility but represses the Rhl quorum-sensing (QS) system, including rhamnolipid production.	Alginates	15-23	alginate biosynthesis regulatory protein AlgR	Pseudomonas aeruginosa PAO1	0-4
29725486-10	2013	Therefore, MSC, delivered in a nanoporous alginate matrix, can modulate responses to injury by reversing fibronectin-induced OHC degradation.	Alginates	42-50	fibronectin 1	Homo sapiens	105-116
23901942-7	2013	Therefore, we conclude that BMP-2 plasmid DNA-based gene therapy in alginate is a promising new strategy for BMP-2 administration for bone (re)generation.	Alginates	68-76	bone morphogenetic protein 2	Mus musculus	28-33
23901942-7	2013	Therefore, we conclude that BMP-2 plasmid DNA-based gene therapy in alginate is a promising new strategy for BMP-2 administration for bone (re)generation.	Alginates	68-76	bone morphogenetic protein 2	Mus musculus	109-114
23886705-7	2013	Finally, implantations of the VEGF-releasing HRP-activated alginate-g-pyrrole hydrogel system on chicken chorioallantoic membranes resulted in the formation of blood vessels in higher densities and with larger diameters, compared to other control conditions.	Alginates	59-67	vascular endothelial growth factor A	Gallus gallus	30-34
24145300-10	2013	Based on these in vitro and in vivo results, the use of the PCL/alginate/BMP-2 scaffold seemed to be a promising technique for the mastoid obliteration.	Alginates	64-72	PHD finger protein 1	Homo sapiens	60-63
23584739-3	2013	In this study, PCL was used as a mechanical supporting component to enhance the mechanical properties of the final biocomposite and alginate was used as the deterring material to control the release of BMP-2 and BFP-1.	Alginates	132-140	bone morphogenetic protein 2	Homo sapiens	202-207
23584739-6	2013	The in vitro test results revealed that PCL/BFP-1/Alginate had significantly higher ALP activity and calcium deposition than the PCL/BMP-2/Alginate composite.	Alginates	50-58	alkaline phosphatase, placental	Homo sapiens	84-87
24145300-6	2013	Furthermore, the PCL/alginate/BMP-2 scaffold showed significantly higher calcium deposition than the PCL/alginate scaffold.	Alginates	21-29	PHD finger protein 1	Homo sapiens	17-20
24145300-6	2013	Furthermore, the PCL/alginate/BMP-2 scaffold showed significantly higher calcium deposition than the PCL/alginate scaffold.	Alginates	21-29	bone morphogenetic protein 2	Homo sapiens	30-35
24145300-6	2013	Furthermore, the PCL/alginate/BMP-2 scaffold showed significantly higher calcium deposition than the PCL/alginate scaffold.	Alginates	105-113	PHD finger protein 1	Homo sapiens	17-20
24145300-8	2013	Confocal microscopic findings showed that the honeycomb appearance of the PCL structure remained in the control group (pure PCL), but significant amount of bone remodeling in the experimental group (PCL/alginate/BMP-2).	Alginates	203-211	PHD finger protein 1	Homo sapiens	74-77
23916821-0	2013	Injectable alginate hydrogel loaded with GDNF promotes functional recovery in a hemisection model of spinal cord injury.	Alginates	11-19	glial cell derived neurotrophic factor	Rattus norvegicus	41-45
24204598-5	2013	Six weeks following subcutaneous transplantation of CD146(+) HUCPVCs-Gelfoam-alginate 3D complexes in severe combined immunodeficiency (SCID) mice, newly formed bone matrix with embedded osteocytes of donor origin was observed.	Alginates	77-85	melanoma cell adhesion molecule	Mus musculus	52-57
23978335-0	2013	FGF-1 delivery from multilayer alginate microbeads stimulates a rapid and persistent increase in vascular density.	Alginates	31-39	fibroblast growth factor 1	Rattus norvegicus	0-5
23978335-3	2013	In the present study, we investigate the use of multilayered alginate microbeads to provide a sustained delivery of FGF-1, and whether this results in increased neovascularization in vivo.	Alginates	61-69	fibroblast growth factor 1	Rattus norvegicus	116-121
23978335-7	2013	Moreover, at 6weeks, alginate microbeads containing 600ng FGF-1 provided a greater vascular density compared to both the control group and the microbeads loaded with 150ng FGF-1.	Alginates	21-29	fibroblast growth factor 1	Rattus norvegicus	58-63
23978335-10	2013	These results suggest that the sustained delivery of FGF-1 from multilayered alginate microbeads results in a rapid and persistent vascular response.	Alginates	77-85	fibroblast growth factor 1	Rattus norvegicus	53-58
23786586-4	2013	In this article, poly-L-lysine-coated vascular endothelial growth factor/alginate controlled releasing microspheres (VEGF-AG-PLL) were fabricated in tissue-engineered bone (TEB), and then the composite was implanted into the CSBD of goat femurs.	Alginates	73-81	vascular endothelial growth factor A	Capra hircus	117-121
24421234-1	2013	OBJECTIVE: To prepare the poly(lactic-co-glycolic acid) (PLGA) microspheres and composite alginate-chitosan-PLGA microspheres containing superoxide dismutase (SOD) and to evaluate their SOD activities.	Alginates	90-98	superoxide dismutase 1	Homo sapiens	137-157
24421234-6	2013	In vitro release tests demonstrated that the SOD activities in 50:50 composite microspheres were higher than that in the PLGA ones at 1 h, 8 h and 1 w. CONCLUSION: The composite alginate-chitosan-PLGA microspheres for SOD sustained release can significantly improve the protein entrapment efficiency and maintain its protein activity.	Alginates	178-186	superoxide dismutase 1	Homo sapiens	45-48
24421234-6	2013	In vitro release tests demonstrated that the SOD activities in 50:50 composite microspheres were higher than that in the PLGA ones at 1 h, 8 h and 1 w. CONCLUSION: The composite alginate-chitosan-PLGA microspheres for SOD sustained release can significantly improve the protein entrapment efficiency and maintain its protein activity.	Alginates	178-186	superoxide dismutase 1	Homo sapiens	218-221
23916821-1	2013	We hypothesized that local delivery of GDNF in spinal cord lesion via an injectable alginate hydrogel gelifying in situ would support spinal cord plasticity and functional recovery.	Alginates	84-92	glial cell derived neurotrophic factor	Rattus norvegicus	39-43
23636927-3	2013	In this study, we evaluate the effects of printing parameters of the Fab@Home 3D printing system on accuracy using alginate, photocrosslinkable polyethylene-glycol diacrylate (PEG-DA) and gelatin as commonly used model hydrogel materials.	Alginates	115-123	FA complementation group B	Homo sapiens	69-72
23796829-2	2013	Insulin-loaded microparticles (INS-MP) made of whey protein (WP) and alginate (ALG) were prepared by a cold gelation technique.	Alginates	69-77	insulin	Homo sapiens	0-7
32260961-7	2013	Because of the mild preparation conditions, bovine serum albumin (BSA) as a model protein was loaded in alginate and CPC pastes prior to plotting with high loading efficiency.	Alginates	104-112	albumin	Homo sapiens	51-64
23977328-0	2013	Sustained release of BMP-2 in bioprinted alginate for osteogenicity in mice and rats.	Alginates	41-49	bone morphogenetic protein 2	Mus musculus	21-26
23512309-3	2013	In this study, alginates were modified with peptides containing RGD (arginine-glycine-aspartic acid) or PHSRN (proline-histidine-serine-arginine-asparagine) sequences from fibronectin to study possible additive and synergistic effects on adherent cells.	Alginates	15-24	fibronectin 1	Homo sapiens	172-183
23384125-0	2013	Novel alginate three-dimensional static and rotating culture systems for effective ex vivo amplification of human cord blood hematopoietic stem cells and in vivo functional analysis of amplified cells in NOD/SCID mice.	Alginates	6-14	atrophin 1	Homo sapiens	204-207
23384125-7	2013	RESULTS: The increase in the cell number and the proportion of CD34+ cells in the CBMCs was more effective in these 3D alginate culture systems than in the conventional 2D culture system under the same conditions (p &lt; 0.05).	Alginates	119-127	CD34 antigen	Mus musculus	63-67
23773817-0	2013	Co-encapsulation of anti-BMP2 monoclonal antibody and mesenchymal stem cells in alginate microspheres for bone tissue engineering.	Alginates	80-88	bone morphogenetic protein 2	Homo sapiens	25-29
23773817-2	2013	The objectives of this study were to: (1) develop a co-delivery system based on murine anti-BMP2 mAb-loaded alginate microspheres encapsulating human bone marrow mesenchymal stem cells (hBMMSCs); and (2) investigate osteogenic differentiation of encapsulated stem cells in alginate microspheres in vitro and in vivo.	Alginates	108-116	bone morphogenetic protein 2	Homo sapiens	92-96
23991093-7	2013	Induction of AlgU(A61V) in trans caused conversion to mucoidy in CF149 and PAO1DalgU, suggesting that AlgU(A61V) is functional in activating alginate production.	Alginates	141-149	RNA polymerase sigma factor AlgU	Pseudomonas aeruginosa PAO1	13-17
23991093-7	2013	Induction of AlgU(A61V) in trans caused conversion to mucoidy in CF149 and PAO1DalgU, suggesting that AlgU(A61V) is functional in activating alginate production.	Alginates	141-149	RNA polymerase sigma factor AlgU	Pseudomonas aeruginosa PAO1	102-106
23608357-27	2013	E2, AMH and VEGF production was higher (P &lt; 0.05) in primary follicle culture with FIBRIN than alginate alone.	Alginates	98-106	vascular endothelial growth factor A	Homo sapiens	12-16
23706229-5	2013	Efficacy of honey-alginate matrix in comparison to only alginate one was demonstrated by a quicker reduction in wound gap, improved cellular viability, enhanced expressions of Ki67, p63 and its isoforms (TAp63, DeltaNp63) as well as E-cadherin.	Alginates	18-26	tumor protein p63	Homo sapiens	182-185
23664939-7	2013	Compared to chitosan/alginate (1/2) hydrogel prepared with 1wt% DCC, the swelling of chitosan/alginate (1/2) hydrogels prepared with 3wt% DCC was limited.	Alginates	94-102	deleted in colorectal carcinoma	Mus musculus	138-141
23664939-10	2013	It was observed that chitosan/alginate (1/2) hydrogels with 1wt% (DCC) provides a better environment for cell attachment and proliferation.	Alginates	30-38	deleted in colorectal carcinoma	Mus musculus	66-69
23706229-5	2013	Efficacy of honey-alginate matrix in comparison to only alginate one was demonstrated by a quicker reduction in wound gap, improved cellular viability, enhanced expressions of Ki67, p63 and its isoforms (TAp63, DeltaNp63) as well as E-cadherin.	Alginates	18-26	cadherin 1	Homo sapiens	233-243
24028003-5	2013	SA coating cast iron (SAC) and reduced iron (SAR) were tested in the treatment of chromium-polluted groundwater individually; the results showed that the removal efficiency of Cr( VI) by SAC was double that by SAR.	Alginates	0-2	sarcosine dehydrogenase	Homo sapiens	210-213
23512074-0	2013	UHV-alginate as matrix for neurotrophic factor producing cells--a novel biomaterial for cochlear implant optimization to preserve inner ear neurons from degeneration.	Alginates	4-12	glial cell line derived neurotrophic factor	Mus musculus	27-46
23512074-1	2013	HYPOTHESIS: Ultra high viscous (UHV-) alginate is a suitable matrix for brain-derived neurotrophic factor (BDNF) producing cells, enabling cell survival and BDNF release out of the matrix and subsequent protection of auditory neuronal cells.	Alginates	38-46	brain derived neurotrophic factor	Mus musculus	72-105
23512074-1	2013	HYPOTHESIS: Ultra high viscous (UHV-) alginate is a suitable matrix for brain-derived neurotrophic factor (BDNF) producing cells, enabling cell survival and BDNF release out of the matrix and subsequent protection of auditory neuronal cells.	Alginates	38-46	brain derived neurotrophic factor	Mus musculus	107-111
23512074-1	2013	HYPOTHESIS: Ultra high viscous (UHV-) alginate is a suitable matrix for brain-derived neurotrophic factor (BDNF) producing cells, enabling cell survival and BDNF release out of the matrix and subsequent protection of auditory neuronal cells.	Alginates	38-46	brain derived neurotrophic factor	Mus musculus	157-161
23512074-8	2013	The supernatant of the alginate-cell culture was added to primary SGC culture, and the neuroprotective effect of the produced BDNF was observed performing SGC counts.	Alginates	23-31	brain derived neurotrophic factor	Mus musculus	126-130
23512074-9	2013	RESULTS: BDNF-producing cells cultivated in UHV-alginate survived for up to 30 days, which was the latest time point observed.	Alginates	48-56	brain derived neurotrophic factor	Mus musculus	9-13
23512074-10	2013	The BDNF concentration in cell culture medium, produced from in UHV-alginate incorporated fibroblasts and released out of the alginate matrix into the medium, was significantly increased after 30 days of cultivation.	Alginates	68-76	brain derived neurotrophic factor	Mus musculus	4-8
23512074-10	2013	The BDNF concentration in cell culture medium, produced from in UHV-alginate incorporated fibroblasts and released out of the alginate matrix into the medium, was significantly increased after 30 days of cultivation.	Alginates	126-134	brain derived neurotrophic factor	Mus musculus	4-8
23512074-11	2013	Supernatant of 7 days incubated UHV-alginate containing NIH3T3/BDNF cells significantly increased the SGC survival in vitro.	Alginates	36-44	brain derived neurotrophic factor	Mus musculus	63-67
32260919-0	2013	Collagen/alginate scaffolds comprising core (PCL)-shell (collagen/alginate) struts for hard tissue regeneration: fabrication, characterisation, and cellular activities.	Alginates	9-17	PHD finger protein 1	Homo sapiens	45-48
23567292-0	2013	Oral delivery of insulin from alginate/chitosan crosslinked by glutaraldehyde.	Alginates	30-38	insulin	Homo sapiens	17-24
23567292-4	2013	In the present study, insulin-loaded alginate/chitosan blend gel beads were prepared with different mass ratios.	Alginates	37-45	insulin	Homo sapiens	22-29
23567292-8	2013	The cumulative insulin release of pure alginate beads (10:0) reached as maximum level 100% in 3h after they were dipped in SIF.	Alginates	39-47	insulin	Homo sapiens	15-22
23567292-12	2013	The alginate/chitosan beads crosslinked by glutaraldehyde may be considered as potential insulin carriers for oral drug delivery system.	Alginates	4-12	insulin	Homo sapiens	89-96
23602170-0	2013	Controlled release of metronidazole from composite poly-epsilon-caprolactone/alginate (PCL/alginate) rings for dental implants.	Alginates	77-85	PHD finger protein 1	Homo sapiens	87-90
23778088-4	2013	Sodium alginate hydrogel was used as the carrier for BMP-2 and bFGF and its features, including gelling, degradation and controlled release properties, was detected by the determination of gelation and degradation time coupled with a controlled release study of bovine serum albumin (BSA).	Alginates	0-15	bone morphogenetic protein 2	Oryctolagus cuniculus	53-58
23778088-4	2013	Sodium alginate hydrogel was used as the carrier for BMP-2 and bFGF and its features, including gelling, degradation and controlled release properties, was detected by the determination of gelation and degradation time coupled with a controlled release study of bovine serum albumin (BSA).	Alginates	0-15	albumin	Oryctolagus cuniculus	269-282
23273882-2	2013	We investigated the effect on neointima formation in porcine saphenous vein grafts of periadventitial application of immortalized human mesenchymal stem cells transduced with the gene for the peptide glucagon-like peptide-1, which have been shown to induce angiogenesis in previous studies and are protected from immune-mediated destruction by encapsulation in alginate microbeads (CellBeads).	Alginates	361-369	glucagon	Homo sapiens	200-223
23623101-1	2013	Silver nanoparticle (AgNP) was incorporated into dopamine-modified alginate/chitosan (DAL/CHI) polyelectrolyte multilayer to modify the surface of titanium alloy and improve its antibacterial property.	Alginates	67-75	peptidase D	Mus musculus	86-89
23602170-9	2013	The PCL/alginate agent release characteristic fits the Ritger-Peppas model indicating a diffusion-based mechanism during the 30-day study period.	Alginates	8-16	PHD finger protein 1	Homo sapiens	4-7
23660804-13	2013	RANTES expression increased more than 200-fold in the alginate culture model in cells treated with IL-1beta/TNF-alpha, 1% fetal bovine serum (P &lt; 0.001).	Alginates	54-62	C-C motif chemokine ligand 5	Homo sapiens	0-6
23197406-5	2013	In addition, while lower expression of integrin beta1 was detected for alginate-coated TiO2 SC at this time point, similar gene expression was observed for other integrins, fibronectin-1, and several osteoblast differentiation markers.	Alginates	71-79	integrin beta 1 (fibronectin receptor beta)	Mus musculus	39-53
23197406-6	2013	After 21 days, gene expression of integrin beta3, fibronectin-1, osterix, and collagen-I was increased in alginate-coated compared to TiO2 SC.	Alginates	106-114	integrin beta 3	Mus musculus	34-48
23197406-6	2013	After 21 days, gene expression of integrin beta3, fibronectin-1, osterix, and collagen-I was increased in alginate-coated compared to TiO2 SC.	Alginates	106-114	fibronectin 1	Mus musculus	50-88
23197406-7	2013	Moreover, increased gene expression of integrin alpha8, bone morphogenetic protein 2, interleukin-6, and collagen-I was found on P2 alginate-coated TiO2 SC compared to alginate-coated TiO2 SC.	Alginates	132-140	integrin alpha 8	Mus musculus	39-54
23197406-7	2013	Moreover, increased gene expression of integrin alpha8, bone morphogenetic protein 2, interleukin-6, and collagen-I was found on P2 alginate-coated TiO2 SC compared to alginate-coated TiO2 SC.	Alginates	132-140	bone morphogenetic protein 2	Mus musculus	56-84
23197406-7	2013	Moreover, increased gene expression of integrin alpha8, bone morphogenetic protein 2, interleukin-6, and collagen-I was found on P2 alginate-coated TiO2 SC compared to alginate-coated TiO2 SC.	Alginates	132-140	interleukin 6	Mus musculus	86-99
23054629-7	2013	For porcine SMSCs, PPIA, and TBP were selected for tissue in alginate scaffold whereas HPRT and TBP were selected for the agarose scaffold system.	Alginates	61-69	peptidyl-prolyl cis-trans isomerase A	Oryctolagus cuniculus	19-23
23054629-7	2013	For porcine SMSCs, PPIA, and TBP were selected for tissue in alginate scaffold whereas HPRT and TBP were selected for the agarose scaffold system.	Alginates	61-69	TATA-box-binding protein	Oryctolagus cuniculus	29-32
23360441-1	2013	This study investigates the effect of insulin-like growth factor (IGF)-I on the development of anatomically-shaped alginate menisci seeded with meniscal fibrochondrocytes.	Alginates	115-123	IGFI	Bos taurus	38-72
22319007-4	2013	Temporal, or on-off, release of IGF-I from cells encapsulated within Ca2+-alginate hydrogels was demonstrated in a pilot study over the course of 10 days in culture.	Alginates	74-82	insulin like growth factor 1	Homo sapiens	32-37
23660804-13	2013	RANTES expression increased more than 200-fold in the alginate culture model in cells treated with IL-1beta/TNF-alpha, 1% fetal bovine serum (P &lt; 0.001).	Alginates	54-62	interleukin 1 beta	Homo sapiens	99-107
23660804-13	2013	RANTES expression increased more than 200-fold in the alginate culture model in cells treated with IL-1beta/TNF-alpha, 1% fetal bovine serum (P &lt; 0.001).	Alginates	54-62	tumor necrosis factor	Homo sapiens	108-120
23675508-0	2013	Sodium alginate microneedle arrays mediate the transdermal delivery of bovine serum albumin.	Alginates	0-15	albumin	Homo sapiens	78-91
23675508-2	2013	The main objective of this study was the determination of the stability and delivery of bovine serum albumin (BSA) that was transported across human skin via sodium alginate (SA) microneedle arrays (MNs) and SA needle free patches using two different analytical methods.	Alginates	111-113	albumin	Homo sapiens	95-108
23456240-11	2013	CONCLUSION: The Wnt + alginate complex exerted significantly enhanced recovery in a rat SCI model compared to alginate or Wnt3a alone.	Alginates	22-30	Wnt family member 3A	Rattus norvegicus	122-127
23456240-11	2013	CONCLUSION: The Wnt + alginate complex exerted significantly enhanced recovery in a rat SCI model compared to alginate or Wnt3a alone.	Alginates	110-118	Wnt family member 3A	Rattus norvegicus	16-19
23456240-2	2013	Here, we studied increasing effect on regeneration by Wnt-containing alginate scaffolds on spinal cord injury (SCI).	Alginates	69-77	Wnt family member 3A	Rattus norvegicus	54-57
23456240-12	2013	These results suggest that alginate scaffolds facilitate the regeneration of axon working with Wnt3a protein that promotes regeneration of the injured spinal cord.	Alginates	27-35	Wnt family member 3A	Rattus norvegicus	95-100
23456240-9	2013	ME-MRI at 8 weeks after SCI revealed significantly higher relative signal intensities in the Wnt + alginate group.	Alginates	99-107	Wnt family member 3A	Rattus norvegicus	93-96
23010124-3	2013	Differentiating iPS cells in NGF-grafted alginate/gamma-PGA constructs were identified by immunochemical staining of anti-SSEA-1 and anti-beta III tubulin.	Alginates	41-49	fucosyltransferase 4	Homo sapiens	122-154
23456240-10	2013	Gap43 and Map2 immunostaining, showed strong positive in the Wnt + alginate group.	Alginates	67-75	growth associated protein 43	Rattus norvegicus	0-5
23456240-10	2013	Gap43 and Map2 immunostaining, showed strong positive in the Wnt + alginate group.	Alginates	67-75	microtubule-associated protein 2	Rattus norvegicus	10-14
23456240-10	2013	Gap43 and Map2 immunostaining, showed strong positive in the Wnt + alginate group.	Alginates	67-75	Wnt family member 3A	Rattus norvegicus	61-64
23082964-0	2013	Calcium-alginate hydrogel-encapsulated fibroblasts provide sustained release of vascular endothelial growth factor.	Alginates	0-16	vascular endothelial growth factor A	Mus musculus	80-114
23319520-0	2013	Horseradish peroxidase/catalase-mediated cell-laden alginate-based hydrogel tube production in two-phase coaxial flow of aqueous solutions for filament-like tissues fabrication.	Alginates	52-60	catalase	Homo sapiens	23-31
23319520-4	2013	An aqueous solution containing an alginate derivative possessing phenolic hydroxyl moieties (Alg-Ph), catalase and horseradish peroxidase (HRP) was extruded into an ambient flow of H(2)O(2) aqueous solution.	Alginates	34-42	catalase	Homo sapiens	102-110
23067437-6	2013	The behavior of C3A cells can be modulated via independent tuning of mechanical stimuli in the 3D alginate hydrogels, which is different from that in the two-dimensional (2D) systems.	Alginates	98-106	complement C3	Homo sapiens	16-19
23466264-1	2013	Here we report on the adsorption performance of calcium alginate (Ca-Alg2) and Ca-Alg2 with encapsulated graphene oxide (Ca-Alg2/GO) gel bead adsorbents for the successful removal of Cu(2+) ions from aqueous solution.	Alginates	48-64	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	69-73
23249253-5	2013	Furthermore, fibronectin (FN) was also immobilized inside alginate beads with high efficiency in order to mimic the composition of the extracellular matrix.	Alginates	58-66	fibronectin 1	Rattus norvegicus	13-24
23249253-5	2013	Furthermore, fibronectin (FN) was also immobilized inside alginate beads with high efficiency in order to mimic the composition of the extracellular matrix.	Alginates	58-66	fibronectin 1	Rattus norvegicus	26-28
23249253-7	2013	The methodology employed allowed the production of alginate beads exhibiting a homogenous rMSCs and FN distribution.	Alginates	51-59	fibronectin 1	Rattus norvegicus	100-102
23879090-9	2013	NPCs in 3-D alginate microsphere culture showed significantly lower proliferation rate than NPCs in the in-vitro monolayer culture (P &lt; 0.05), but it could significantly improve the protein expressions of collagen type II and Aggrecan in dedifferentiated NPCs, showing significantly difference between groups E and A (P &lt; 0.05).	Alginates	12-20	aggrecan	Homo sapiens	208-237
23879090-13	2013	In 3-D alginate microsphere culture, RES could restore the phenotype of dedifferentiated NPCs and synthesize more extracellular matrix, which is related to the regulation of SIRT1.	Alginates	7-15	sirtuin 1	Homo sapiens	174-179
23499072-1	2013	Collagen peptides grafted sodium alginate (SA-COP) was prepared by reacting alginate with collagen peptide via amide linkage in presence of 1-ethyl-(dimethylaminopropyl) carbodiimide (EDC) and N-hydroxy sulfosuccinimide (NHS).	Alginates	26-41	caspase recruitment domain family member 16	Homo sapiens	46-49
23499072-1	2013	Collagen peptides grafted sodium alginate (SA-COP) was prepared by reacting alginate with collagen peptide via amide linkage in presence of 1-ethyl-(dimethylaminopropyl) carbodiimide (EDC) and N-hydroxy sulfosuccinimide (NHS).	Alginates	33-41	caspase recruitment domain family member 16	Homo sapiens	46-49
23369755-0	2013	Guided differentiation of induced pluripotent stem cells into neuronal lineage in alginate-chitosan-gelatin hydrogels with surface neuron growth factor.	Alginates	82-90	nerve growth factor	Homo sapiens	131-151
22213742-0	2013	Encapsulation of cardiac stem cells in superoxide dismutase-loaded alginate prevents doxorubicin-mediated toxicity.	Alginates	67-75	superoxide dismutase 1	Homo sapiens	39-59
22213742-6	2013	Therefore, this study aims to enhance CSC survival by encapsulation in an alginate hydrogel formulation containing superoxide dismutase (SOD), a reactive oxygen species scavenger.	Alginates	74-82	superoxide dismutase 1	Homo sapiens	115-135
22213742-6	2013	Therefore, this study aims to enhance CSC survival by encapsulation in an alginate hydrogel formulation containing superoxide dismutase (SOD), a reactive oxygen species scavenger.	Alginates	74-82	superoxide dismutase 1	Homo sapiens	137-140
22213742-10	2013	Encapsulation in SOD-loaded alginate reduced apoptosis to near-normal levels, whilst metabolic activity was returned to baseline.	Alginates	28-36	superoxide dismutase 1	Homo sapiens	17-20
22213742-11	2013	In conclusion, this study demonstrates that encapsulation of CSCs in SOD-loaded alginate hydrogel enhances CSC survival in the presence of DOX, raising the possibility of its application as a novel therapy for the treatment of acute and early onset DOX-induced cardiotoxicity.	Alginates	80-88	superoxide dismutase 1	Homo sapiens	69-72
23093377-2	2013	METHODS: Insulin-loaded microparticles (ins-MP) made of whey protein and alginate were prepared by a cold gelation technique and an adsorption method, without adjunction of organic solvent in order to develop a biocompatible vehicle for oral administration of insulin.	Alginates	73-81	insulin	Oryctolagus cuniculus	9-16
22886446-8	2013	Furthermore, when recombinant DsRed was tagged with TQ1 sequence at its C-terminal, DsRed-TQ1 underwent efficient covalent-immobilization onto alginate-gelatin bead by STG reaction, showing a Q-peptide application as a useful tagging molecule.	Alginates	143-151	selectin L	Homo sapiens	52-55
22886446-8	2013	Furthermore, when recombinant DsRed was tagged with TQ1 sequence at its C-terminal, DsRed-TQ1 underwent efficient covalent-immobilization onto alginate-gelatin bead by STG reaction, showing a Q-peptide application as a useful tagging molecule.	Alginates	143-151	selectin L	Homo sapiens	90-93
22886446-8	2013	Furthermore, when recombinant DsRed was tagged with TQ1 sequence at its C-terminal, DsRed-TQ1 underwent efficient covalent-immobilization onto alginate-gelatin bead by STG reaction, showing a Q-peptide application as a useful tagging molecule.	Alginates	143-151	chromosome 6 open reading frame 15	Homo sapiens	168-171
24231999-8	2013	Alginate microcapsules encapsulating 293TIMP2 cells released TIMP2 protein into the medium efficiently, where the TIMP2 protein participated in degradation of the matrix metalloproteinase-2 enzyme and inhibited invasion of U87MG cells.	Alginates	0-8	TIMP metallopeptidase inhibitor 2	Homo sapiens	40-45
22994418-3	2013	In this study, we used the osteoconductive and mechanical properties of nano-scale calcium sulfate (nCS) and the biocompatibility of alginate to develop the injectable nCS/alginate (nCS/A) paste, and characterized the effect of this nCS/A paste loaded with bone morphogenetic protein 2 (BMP2) gene-modified rat mesenchymal stem cells (MSCs) on bone and blood vessel growth.	Alginates	172-180	bone morphogenetic protein 2	Rattus norvegicus	257-285
22994418-3	2013	In this study, we used the osteoconductive and mechanical properties of nano-scale calcium sulfate (nCS) and the biocompatibility of alginate to develop the injectable nCS/alginate (nCS/A) paste, and characterized the effect of this nCS/A paste loaded with bone morphogenetic protein 2 (BMP2) gene-modified rat mesenchymal stem cells (MSCs) on bone and blood vessel growth.	Alginates	172-180	bone morphogenetic protein 2	Rattus norvegicus	287-291
24592443-9	2013	Alginate significantly reduced the activity of stress enzymes catalase and peroxidase, which could indicate damage in the defense system.	Alginates	0-8	peroxidase 1	Zea mays	75-85
23251248-0	2013	Bone marrow mesenchymal stem cells combined with calcium alginate gel modified by hTGF-beta1 for the construction of tissue-engineered cartilage in three-dimensional conditions.	Alginates	49-65	transforming growth factor beta 1	Homo sapiens	82-92
24231999-0	2013	Release of tissue inhibitor of metalloproteinase-2 from alginate microcapsule encapsulating genetically engineered cells.	Alginates	56-64	TIMP metallopeptidase inhibitor 2	Homo sapiens	11-50
23283383-8	2013	The PLGA guidance fibers within the nerve repair conduit lumen are supported within an alginate hydrogel impregnated with neurotrophic factors (NT-3 or BDNF with LIF, SMDF and MGF-1) to provide neuroprotection, stimulation of axonal growth and Schwann cell migration.	Alginates	87-95	neurotrophin 3	Rattus norvegicus	144-148
22894570-0	2013	Enhanced control of in vivo bone formation with surface functionalized alginate microbeads incorporating heparin and human bone morphogenetic protein-2.	Alginates	71-79	bone morphogenetic protein 2	Homo sapiens	123-151
23151183-11	2013	TGF-beta1 positive cells were more abundant in FF3-, FF5-treated alginate dressing treated wound at day 3 and 14.	Alginates	65-73	transforming growth factor, beta 1	Rattus norvegicus	0-9
24231999-8	2013	Alginate microcapsules encapsulating 293TIMP2 cells released TIMP2 protein into the medium efficiently, where the TIMP2 protein participated in degradation of the matrix metalloproteinase-2 enzyme and inhibited invasion of U87MG cells.	Alginates	0-8	TIMP metallopeptidase inhibitor 2	Homo sapiens	61-66
24231999-8	2013	Alginate microcapsules encapsulating 293TIMP2 cells released TIMP2 protein into the medium efficiently, where the TIMP2 protein participated in degradation of the matrix metalloproteinase-2 enzyme and inhibited invasion of U87MG cells.	Alginates	0-8	matrix metallopeptidase 2	Homo sapiens	163-189
22889091-0	2013	An appropriate selection of a 3D alginate culture model for hepatic Huh-7 cell line encapsulation intended for viral studies.	Alginates	33-41	MIR7-3 host gene	Homo sapiens	68-73
24454406-6	2013	The combination of GDF5 gene transfer and 3D culture in alginate showed an upregulation of aggrecan and SOX9, two markers for chondrogenesis, and KRT19 as a marker for discogenesis compared to untransfected cells.	Alginates	56-64	growth differentiation factor 5	Homo sapiens	19-23
24454406-6	2013	The combination of GDF5 gene transfer and 3D culture in alginate showed an upregulation of aggrecan and SOX9, two markers for chondrogenesis, and KRT19 as a marker for discogenesis compared to untransfected cells.	Alginates	56-64	SRY-box transcription factor 9	Homo sapiens	104-108
24454406-6	2013	The combination of GDF5 gene transfer and 3D culture in alginate showed an upregulation of aggrecan and SOX9, two markers for chondrogenesis, and KRT19 as a marker for discogenesis compared to untransfected cells.	Alginates	56-64	keratin 19	Homo sapiens	146-151
23696702-7	2013	Preadsorbing alginate further decreased cancer cell function, with nanostructured PLGA preadsorbed with alginate achieving the greatest decrease in synthesis of VEGF in both lung and breast cancer cells.	Alginates	104-112	vascular endothelial growth factor A	Homo sapiens	161-165
23116778-3	2013	In this study, acylase was immobilized into sodium alginate capsules for enzymatic quorum quenching in MBRs operated at typical sludge concentrations (MLSS   10 g/L) for extended period of time.	Alginates	44-59	aminoacylase 1	Homo sapiens	15-22
23294716-11	2013	CONCLUSION: The LIPUS can stimulate the extracellular matrix synthesis of degenerative human nucleus pulposus cells cultured in calcium alginate beads via activating PI3K/Akt pathway.	Alginates	128-144	AKT serine/threonine kinase 1	Homo sapiens	171-174
23675280-1	2012	OBJECTIVE: Using the alginate bead three-dimensional culturing method, which is considered to be advantageous for the in vitro study of chondrocytes, we confirmed earlier reports concerning the inhibitory effect of TGF-beta on IL-1beta-induced cartilage destruction and serially evaluated changes in proteinases and their inhibitors in cartilage destruction.	Alginates	21-29	transforming growth factor beta 1	Homo sapiens	215-223
23064128-1	2012	Insulin was encapsulated into microparticles (MP) made of denaturized whey proteins (WP) and alginate (ALG) using an extrusion/cold gelation process with calcium ions.	Alginates	93-101	insulin	Homo sapiens	0-7
22981779-3	2012	We hypothesized that a mixture of platelet-rich plasma (PRP) and adipose-derived stem cells (ADSCs) could endue the alginate microspheres with osteogenic and angiogenic potential.	Alginates	116-124	complement component 4 binding protein alpha	Homo sapiens	34-54
22981779-3	2012	We hypothesized that a mixture of platelet-rich plasma (PRP) and adipose-derived stem cells (ADSCs) could endue the alginate microspheres with osteogenic and angiogenic potential.	Alginates	116-124	complement component 4 binding protein alpha	Homo sapiens	56-59
22981779-6	2012	First, we demonstrated that PRP sustained cell viability and meanwhile promoted cell migration from the interior of alginate microspheres to the surface.	Alginates	116-124	complement component 4 binding protein alpha	Homo sapiens	28-31
22959955-6	2012	Furthermore, that HAp/chitosan-alginate composite scaffold has been shown to be more effective for new bone generation than chitosan-alginate scaffold.	Alginates	31-39	scaffold attachment factor B	Mus musculus	18-21
23675280-2	2012	METHODS: Chondrocytes were cultured on alginate beads with IL-1beta or TGF-beta alone or both.	Alginates	39-47	interleukin 1 beta	Homo sapiens	59-67
22674584-0	2012	Matrix molecule influence on chondrocyte phenotype and proteoglycan 4 expression by alginate-embedded zonal chondrocytes and mesenchymal stem cells.	Alginates	84-92	proteoglycan 4	Bos taurus	55-69
22966120-2	2012	SP-A prevented the invasion of AEC by alginate-producing P. aeruginosa strains because of a direct effect on the AEC.	Alginates	38-46	surfactant protein A1	Homo sapiens	0-4
22966120-5	2012	Alginate binding to AEC reduced SP-A release by these cells.	Alginates	0-8	surfactant protein A1	Homo sapiens	32-36
22966120-6	2012	Because the alginate exopolysaccharide is surface-exposed, levels of SP-A may be crucial to modulate the interaction of P. aeruginosa with AEC.	Alginates	12-20	surfactant protein A1	Homo sapiens	69-73
22674584-5	2012	Here we investigate the expression of PRG4 mRNA and protein by primary bovine superficial zone chondrocytes, middle/deep zone chondrocytes, and mesenchymal stem cells encapsulated in alginate hydrogels with hyaluronic acid (HA) and chondroitin sulfate (CS) additives.	Alginates	183-191	proteoglycan 4	Bos taurus	38-42
22932810-8	2012	Compared with previous publications on screening for AChE inhibitors in natural products based on CE methods, the method developed in this work has the advantages of lower cost per analysis, less leakage, and better bioaffinity for the immobilized enzyme because of the unique properties of sodium alginate and chitosan.	Alginates	291-306	acetylcholinesterase (Cartwright blood group)	Homo sapiens	53-57
22840222-5	2012	Fibroblasts adhered to the alginate-g-pyrrole hydrogels, and exhibited increased proliferation and overall vascular endothelial growth factor (VEGF) expression, compared to those on pyrrole-free hydrogels.	Alginates	27-35	vascular endothelial growth factor A	Gallus gallus	107-141
22840222-5	2012	Fibroblasts adhered to the alginate-g-pyrrole hydrogels, and exhibited increased proliferation and overall vascular endothelial growth factor (VEGF) expression, compared to those on pyrrole-free hydrogels.	Alginates	27-35	vascular endothelial growth factor A	Gallus gallus	143-147
23083953-2	2012	The objective of the present study was to determine the effects of platelet-rich plasma (PRP) on proliferation and osteogenic differentiation of MSCs by encapsulation of PRP into 3-dimensional alginate hydrogel in vitro and in vivo.	Alginates	193-201	proline rich protein 2-like 1	Rattus norvegicus	89-92
23083953-8	2012	RESULTS: After 1, 7, 14, and 21 days of stimulation, PRP significantly promoted MSC proliferation in PRP-alginate gel mixture cultures.	Alginates	105-113	proline rich protein 2-like 1	Rattus norvegicus	53-56
23083953-8	2012	RESULTS: After 1, 7, 14, and 21 days of stimulation, PRP significantly promoted MSC proliferation in PRP-alginate gel mixture cultures.	Alginates	105-113	proline rich protein 2-like 1	Rattus norvegicus	101-104
23083953-9	2012	ALP activity, calcium deposition, and real-time RT-PCR showed enhanced cell osteogenic differentiation in the PRP-alginate group.	Alginates	114-122	proline rich protein 2-like 1	Rattus norvegicus	110-113
23083953-10	2012	Histologic examination demonstrated that large amount of fibrous tissue capsule, collagen, and new vascular growth were detected in the PRP-MSCs-alginate group compared with the alginate and MSCs-alginate groups.	Alginates	145-153	proline rich protein 2-like 1	Rattus norvegicus	136-139
23083953-11	2012	CONCLUSIONS: The results of this study suggest that MSCs induced by PRP encapsulated in an alginate gel mixture can undergo induction into osteoblastic phenotype both in vitro and in vivo, which makes the production of PRP-enhanced tissue-engineered bone using MSCs possible.	Alginates	91-99	proline rich protein 2-like 1	Rattus norvegicus	68-71
23083953-11	2012	CONCLUSIONS: The results of this study suggest that MSCs induced by PRP encapsulated in an alginate gel mixture can undergo induction into osteoblastic phenotype both in vitro and in vivo, which makes the production of PRP-enhanced tissue-engineered bone using MSCs possible.	Alginates	91-99	proline rich protein 2-like 1	Rattus norvegicus	219-222
22972360-6	2012	In addition, we proved a modified alginate microcapsule to directly induce adipogenic differentiation of incorporated hASC.	Alginates	34-42	PYD and CARD domain containing	Homo sapiens	118-122
22782012-5	2012	In the present study, relative mRNA expression levels of integrin alpha 8 were induced by P5 compared to untreated alginate gel, and osteopontin mRNA levels were increased after 21 days of culture by treatment with synthetic peptides or EMD compared to control.	Alginates	115-123	integrin alpha 8	Mus musculus	57-73
22950801-0	2012	TEMPO-oxidized nanocellulose participating as crosslinking aid for alginate-based sponges.	Alginates	67-75	activation induced cytidine deaminase	Homo sapiens	59-62
22623322-0	2012	Alginates induce differentiation and expression of CXCR7 and CXCL12/SDF-1 in human keratinocytes--the role of calcium.	Alginates	0-9	atypical chemokine receptor 3	Homo sapiens	51-56
22623322-0	2012	Alginates induce differentiation and expression of CXCR7 and CXCL12/SDF-1 in human keratinocytes--the role of calcium.	Alginates	0-9	C-X-C motif chemokine ligand 12	Homo sapiens	61-67
22623322-0	2012	Alginates induce differentiation and expression of CXCR7 and CXCL12/SDF-1 in human keratinocytes--the role of calcium.	Alginates	0-9	C-X-C motif chemokine ligand 12	Homo sapiens	68-73
22623322-7	2012	Q-PCR revealed that also CXCL12/SDF-1, one of two known CXCR7-ligands, was induced by the alginates.	Alginates	90-99	C-X-C motif chemokine ligand 12	Homo sapiens	25-31
22623322-7	2012	Q-PCR revealed that also CXCL12/SDF-1, one of two known CXCR7-ligands, was induced by the alginates.	Alginates	90-99	C-X-C motif chemokine ligand 12	Homo sapiens	32-37
22623322-7	2012	Q-PCR revealed that also CXCL12/SDF-1, one of two known CXCR7-ligands, was induced by the alginates.	Alginates	90-99	atypical chemokine receptor 3	Homo sapiens	56-61
22623322-8	2012	Both CXCR7 and CXCL12-induction was dependent on the alginate G-content, and highest upregulation was induced by an alginate with 19% single G residues.	Alginates	53-61	atypical chemokine receptor 3	Homo sapiens	5-10
22623322-8	2012	Both CXCR7 and CXCL12-induction was dependent on the alginate G-content, and highest upregulation was induced by an alginate with 19% single G residues.	Alginates	53-61	C-X-C motif chemokine ligand 12	Homo sapiens	15-21
22623322-8	2012	Both CXCR7 and CXCL12-induction was dependent on the alginate G-content, and highest upregulation was induced by an alginate with 19% single G residues.	Alginates	116-124	atypical chemokine receptor 3	Homo sapiens	5-10
22623322-8	2012	Both CXCR7 and CXCL12-induction was dependent on the alginate G-content, and highest upregulation was induced by an alginate with 19% single G residues.	Alginates	116-124	C-X-C motif chemokine ligand 12	Homo sapiens	15-21
22734611-0	2012	Novel alginate-enclosed chitosan-calcium phosphate-loaded iron-saturated bovine lactoferrin nanocarriers for oral delivery in colon cancer therapy.	Alginates	6-14	lactotransferrin	Bos taurus	80-91
22488450-7	2012	Correspondingly, FGF-2-mediated proteoglycan loss was effectively reversed by individual pathway-specific inhibitor of Ras, PKCdelta, and ERK1/2 in both 3-dimensional alginate bead culture and cartilage organ culture systems.	Alginates	167-175	fibroblast growth factor 2	Homo sapiens	17-22
21680610-0	2012	Fabrication of oxidized alginate-gelatin-BCP hydrogels and evaluation of the microstructure, material properties and biocompatibility for bone tissue regeneration.	Alginates	24-32	opsin 1, short wave sensitive	Homo sapiens	41-44
22894610-2	2012	Using a coprecipitation method, doxorubicin hydrochloride (DOX), an antitumor drug, and p53 expression plasmid were encapsulated in alginate/CaCO(3)/DNA/DOX nanoparticles with high encapsulation efficiency.	Alginates	132-140	tumor protein p53	Homo sapiens	88-91
23243872-3	2012	It was found that, TOC detector was capable of detecting all kinds of organic matters, including sucrose, sodium alginate and other hydrophilic organic compounds.	Alginates	106-121	rhomboid 5 homolog 2	Homo sapiens	19-22
22488450-7	2012	Correspondingly, FGF-2-mediated proteoglycan loss was effectively reversed by individual pathway-specific inhibitor of Ras, PKCdelta, and ERK1/2 in both 3-dimensional alginate bead culture and cartilage organ culture systems.	Alginates	167-175	protein kinase C delta	Homo sapiens	124-132
22488450-7	2012	Correspondingly, FGF-2-mediated proteoglycan loss was effectively reversed by individual pathway-specific inhibitor of Ras, PKCdelta, and ERK1/2 in both 3-dimensional alginate bead culture and cartilage organ culture systems.	Alginates	167-175	mitogen-activated protein kinase 3	Homo sapiens	138-144
22658830-1	2012	Alginate-Fe(2+)/Fe(3+) polymer coated Fe(3)O(4) magnetic nanoparticles (Fe(3)O(4)@ALG/Fe MNPs) with core/shell structure are prepared and used as heterogeneous Fenton nanocatalyst to degrade norfloxacin (NOF).	Alginates	0-8	mitochondrial ribosomal protein L49	Homo sapiens	204-207
22351845-1	2012	OBJECTIVE: To increase the viability of fat grafts using vascular endothelial growth factor (VEGF) in a calcium alginate microsphere controlled release system.	Alginates	104-120	vascular endothelial growth factor A	Rattus norvegicus	57-91
21863459-7	2012	RESULTS: MSCs in collagen matrixes and gelatin produced more mRNA and proteins of the chondrogenic markers collagen type I, collagen type II (COL2) and aggrecan (ACAN), when compared with cells embedded in alginate or chitosan.	Alginates	206-214	aggrecan	Homo sapiens	162-166
22472038-4	2012	METHODS: We produced alginate microcapsules containing baby hamster kidney (BHK) cells overexpressing IDUA and implanted these capsules in the peritoneum of MPS I mice.	Alginates	21-29	alpha-L-iduronidase	Mesocricetus auratus	102-106
22504076-0	2012	Engineered endothelial cell adhesion via VCAM1 and E-selectin antibody-presenting alginate hydrogels.	Alginates	82-90	selectin E	Homo sapiens	51-61
22504076-3	2012	In this study, we mimicked cell-cell interactions by seeding cells on alginate hydrogels modified with antibodies against E-selectin and VCAM1, which are upregulated during inflammation.	Alginates	70-78	selectin E	Homo sapiens	122-132
22504076-3	2012	In this study, we mimicked cell-cell interactions by seeding cells on alginate hydrogels modified with antibodies against E-selectin and VCAM1, which are upregulated during inflammation.	Alginates	70-78	vascular cell adhesion molecule 1	Homo sapiens	137-142
22351845-1	2012	OBJECTIVE: To increase the viability of fat grafts using vascular endothelial growth factor (VEGF) in a calcium alginate microsphere controlled release system.	Alginates	104-120	vascular endothelial growth factor A	Rattus norvegicus	93-97
21360689-0	2012	Gene expression of alginate-embedded chondrocyte subpopulations and their response to exogenous IGF-1 delivery.	Alginates	19-27	insulin like growth factor 1	Bos taurus	96-101
22519841-3	2012	Two capture stages containing antibody-functionalized alginate hydrogels are utilized for the isolation of CD34+ and Flk1+ cells from untreated, whole human blood.	Alginates	54-62	CD34 molecule	Homo sapiens	107-111
22519841-3	2012	Two capture stages containing antibody-functionalized alginate hydrogels are utilized for the isolation of CD34+ and Flk1+ cells from untreated, whole human blood.	Alginates	54-62	kinase insert domain receptor	Homo sapiens	117-121
22385328-7	2012	Levels of TNF-alpha were significantly lower (p &lt; 0.0001) in LPS-stimulated cells that were transfected with mIL-10 using alginate nanoparticles.	Alginates	125-133	tumor necrosis factor	Homo sapiens	10-19
22385328-7	2012	Levels of TNF-alpha were significantly lower (p &lt; 0.0001) in LPS-stimulated cells that were transfected with mIL-10 using alginate nanoparticles.	Alginates	125-133	interleukin 10	Mus musculus	112-118
22304816-0	2012	A superoxide anion biosensor based on direct electron transfer of superoxide dismutase on sodium alginate sol-gel film and its application to monitoring of living cells.	Alginates	90-105	superoxide dismutase 1	Homo sapiens	66-86
22304816-1	2012	The direct electron transfer of superoxide dismutase (SOD) was greatly facilitated by sodium alginate (SA) sol-gel film with the formal potential of 0.14 V, which was just located between O(2)( -)/O(2) and O(2)( -)/H(2)O(2).	Alginates	86-101	superoxide dismutase 1	Homo sapiens	32-52
22304816-1	2012	The direct electron transfer of superoxide dismutase (SOD) was greatly facilitated by sodium alginate (SA) sol-gel film with the formal potential of 0.14 V, which was just located between O(2)( -)/O(2) and O(2)( -)/H(2)O(2).	Alginates	86-101	superoxide dismutase 1	Homo sapiens	54-57
22304816-1	2012	The direct electron transfer of superoxide dismutase (SOD) was greatly facilitated by sodium alginate (SA) sol-gel film with the formal potential of 0.14 V, which was just located between O(2)( -)/O(2) and O(2)( -)/H(2)O(2).	Alginates	103-105	superoxide dismutase 1	Homo sapiens	32-52
22304816-1	2012	The direct electron transfer of superoxide dismutase (SOD) was greatly facilitated by sodium alginate (SA) sol-gel film with the formal potential of 0.14 V, which was just located between O(2)( -)/O(2) and O(2)( -)/H(2)O(2).	Alginates	103-105	superoxide dismutase 1	Homo sapiens	54-57
22304816-3	2012	Based on bimolecular recognition for specific reactivity of SOD/SA toward O(2)( -), the SOD modified electrode was utilized to measure O(2)( -) with good analytical performance, such as low applied potential (0 V), high selectivity (no obvious interference), wide linear range (0.44-229.88 muM) and low detection limit (0.23 muM) in pH 7.0 phosphate buffer solution.	Alginates	64-66	superoxide dismutase 1	Homo sapiens	88-91
22506765-0	2012	Alginate-PEG sponge architecture and role in the design of insulin release dressings.	Alginates	0-8	insulin	Homo sapiens	59-66
22375937-1	2012	The objective of this work is to use colloidal gel from alginate-chitosan-PLGA complex to deliver Ac-PLP-BPI-NH2-2 peptide in a controlled-release manner as a vaccine-like therapeutic to suppress experimental autoimmune encephalomyelitis (EAE) in the mouse model.	Alginates	56-64	proteolipid protein (myelin) 1	Mus musculus	101-104
22375937-1	2012	The objective of this work is to use colloidal gel from alginate-chitosan-PLGA complex to deliver Ac-PLP-BPI-NH2-2 peptide in a controlled-release manner as a vaccine-like therapeutic to suppress experimental autoimmune encephalomyelitis (EAE) in the mouse model.	Alginates	56-64	bactericidal permeablility increasing protein	Mus musculus	105-108
22011105-0	2012	Adipose tissue engineering using injectable, oxidized alginate hydrogels.	Alginates	54-62	WD and tetratricopeptide repeats 1	Mus musculus	0-7
22011105-3	2012	This study investigated the feasibility of a degradable alginate hydrogel system with commercially available cryopreserved human adipose stem cells (hADSCs) to engineer adipose tissue.	Alginates	56-64	WD and tetratricopeptide repeats 1	Mus musculus	169-176
22011105-9	2012	This study demonstrates that degradable, injectable alginate hydrogels provide a suitable delivery vehicle for preconditioned cryopreserved hADSCs to engineer adipose tissue.	Alginates	52-60	WD and tetratricopeptide repeats 1	Mus musculus	159-166
22365120-1	2012	Sodium alginate (AlgNa) and poly(diallyldimethylammonium chloride) (PDDA) were mixed to obtain an interpenetrating polymer composite via electrostatic interaction and then cast on an Au electrode surface, followed by incorporation of metal ions (e.g. Fe(3+) or Ca(2+), to form AlgFe or AlgCa hydrogel) and glucose oxidase (GOx) (or lactate oxidase (LOx)), to prepare amperometric enzyme electrodes.	Alginates	0-15	hydroxyacid oxidase 1	Homo sapiens	306-321
22365120-1	2012	Sodium alginate (AlgNa) and poly(diallyldimethylammonium chloride) (PDDA) were mixed to obtain an interpenetrating polymer composite via electrostatic interaction and then cast on an Au electrode surface, followed by incorporation of metal ions (e.g. Fe(3+) or Ca(2+), to form AlgFe or AlgCa hydrogel) and glucose oxidase (GOx) (or lactate oxidase (LOx)), to prepare amperometric enzyme electrodes.	Alginates	0-15	hydroxyacid oxidase 1	Homo sapiens	323-326
22365120-1	2012	Sodium alginate (AlgNa) and poly(diallyldimethylammonium chloride) (PDDA) were mixed to obtain an interpenetrating polymer composite via electrostatic interaction and then cast on an Au electrode surface, followed by incorporation of metal ions (e.g. Fe(3+) or Ca(2+), to form AlgFe or AlgCa hydrogel) and glucose oxidase (GOx) (or lactate oxidase (LOx)), to prepare amperometric enzyme electrodes.	Alginates	0-15	lysyl oxidase	Homo sapiens	332-347
22365120-1	2012	Sodium alginate (AlgNa) and poly(diallyldimethylammonium chloride) (PDDA) were mixed to obtain an interpenetrating polymer composite via electrostatic interaction and then cast on an Au electrode surface, followed by incorporation of metal ions (e.g. Fe(3+) or Ca(2+), to form AlgFe or AlgCa hydrogel) and glucose oxidase (GOx) (or lactate oxidase (LOx)), to prepare amperometric enzyme electrodes.	Alginates	0-15	lysyl oxidase	Homo sapiens	349-352
22210761-2	2012	Alginate biosynthesis is initiated by the extracytoplasmic function sigma factor (sigma(22); AlgU/AlgT).	Alginates	0-8	RNA polymerase sigma factor AlgU	Pseudomonas aeruginosa PAO1	93-97
22210761-3	2012	In the wild-type (wt) nonmucoid strains, such as PAO1, AlgU is sequestered to the cytoplasmic membrane by the anti-sigma factor MucA that inhibits alginate production.	Alginates	147-155	RNA polymerase sigma factor AlgU	Pseudomonas aeruginosa PAO1	55-59
22210761-10	2012	In addition to alginate biosynthetic and regulatory genes, KinB and RpoN also control a large number of genes including those involved in carbohydrate metabolism, quorum sensing, iron regulation, rhamnolipid production, and motility.	Alginates	15-23	RNA polymerase factor sigma-54	Pseudomonas aeruginosa PAO1	68-72
22262729-0	2012	Rotary culture promotes the proliferation of MCF-7 cells encapsulated in three-dimensional collagen-alginate hydrogels via activation of the ERK1/2-MAPK pathway.	Alginates	100-108	mitogen-activated protein kinase 3	Homo sapiens	141-147
21953367-5	2012	RESULTS: The beads obtained with approximately 2 mg g-1 of gallic acid equivalents encapsulated in 0.015 g mL-1 of alginate were spheres of a uniform size of about 730 microm.	Alginates	115-123	L1 cell adhesion molecule	Mus musculus	107-111
22241609-4	2012	To promote chondrogenic differentiation, we used lentivirus to transduce iPSCs seeded in alginate matrix with transforming growth factor-beta1 (TGF-beta1) and then in vitro co-cultured these iPSCs with chondrocytes.	Alginates	89-97	transforming growth factor beta 1	Homo sapiens	110-142
21902605-5	2012	To generate the implant, NELL-1 was incorporated into chitosan nanoparticles and embedded into alginate hydrogels.	Alginates	95-103	protein kinase C-binding protein NELL1	Oryctolagus cuniculus	25-31
21902605-9	2012	Defects filled with alginate containing NELL-1 demonstrated significantly improved cartilage regeneration.	Alginates	20-28	protein kinase C-binding protein NELL1	Oryctolagus cuniculus	40-46
22241609-4	2012	To promote chondrogenic differentiation, we used lentivirus to transduce iPSCs seeded in alginate matrix with transforming growth factor-beta1 (TGF-beta1) and then in vitro co-cultured these iPSCs with chondrocytes.	Alginates	89-97	transforming growth factor beta 1	Homo sapiens	144-153
22241609-7	2012	The histological results revealed a dense sulphated extracellular matrix in the co-culture of TGF-beta1-transfected iPSCs with chondrocytes in alginate matrix.	Alginates	143-151	transforming growth factor beta 1	Homo sapiens	94-103
22241609-9	2012	Histological examination revealed that more new cartilage was formed in the co-culture of TGF-beta1-transfected iPSCs with chondrocytes in alginate matrix.	Alginates	139-147	transforming growth factor beta 1	Homo sapiens	90-99
23231959-3	2012	To promote islet vascularization, the BI incorporates a spherical alginate hydrogel for sustained release of vascular endothelial growth factor (VEGF).	Alginates	66-74	vascular endothelial growth factor A	Mus musculus	109-143
23231959-3	2012	To promote islet vascularization, the BI incorporates a spherical alginate hydrogel for sustained release of vascular endothelial growth factor (VEGF).	Alginates	66-74	vascular endothelial growth factor A	Mus musculus	145-149
22242022-7	2012	Proton pump inhibitors do not help the majority with extraesophageal reflux but specifically formulated alginates, which sieve pepsin, give benefit.	Alginates	104-113	ATPase H+/K+ transporting subunit alpha	Homo sapiens	0-11
23198137-4	2012	alpha-amylase was immobilized on to calcium alginate hydrogel beads of 2 mm average diameter.	Alginates	36-52	alpha-amylase	Zea mays	0-13
22340556-11	2012	CONCLUSIONS: Combination therapy using an alginate dressing and mEGF shows increased proliferation and differentiation of ESCs in patients with refractory wounds compared with those treated with mEGF alone.	Alginates	42-50	epidermal growth factor	Mus musculus	195-199
22262719-5	2012	Forced elution studies in vitro using a USP-4 flow-through apparatus demonstrated that the alginate excipient helped to reduce the burst effect and rate the elution from the beads.	Alginates	91-99	ubiquitin specific peptidase 4	Rattus norvegicus	40-45
21960023-15	2012	We conclude that sustained intrapericardial release of bFGF + VEGF from alginate beads attached to the epicardium facilitated vascular growth in the cryoinjured area.	Alginates	72-80	fibroblast growth factor 2	Homo sapiens	55-59
22182333-8	2012	The amount of strongly bound water present in the hydrogels were estimated from TGA and DSC analysis and the highest value was found for alginate-agarose hydrogels as about 15%.	Alginates	137-145	T-box transcription factor 1	Homo sapiens	80-83
22160783-0	2012	Encapsulation of Huh-7 cells within alginate-poly(ethylene glycol) hybrid microspheres.	Alginates	36-44	MIR7-3 host gene	Homo sapiens	17-22
22612554-0	2012	Chitosan scaffolds with BMP-6 loaded alginate microspheres for periodontal tissue engineering.	Alginates	37-45	bone morphogenetic protein 6	Rattus norvegicus	24-29
22612554-2	2012	Bone morphogenetic protein-6 (BMP-6)-loaded alginate microspheres in narrow size distribution were produced by optimising electrospraying conditions.	Alginates	44-52	bone morphogenetic protein 6	Rattus norvegicus	0-28
22612554-2	2012	Bone morphogenetic protein-6 (BMP-6)-loaded alginate microspheres in narrow size distribution were produced by optimising electrospraying conditions.	Alginates	44-52	bone morphogenetic protein 6	Rattus norvegicus	30-35
22612554-6	2012	Results showed that controlled delivery of BMP-6 from alginate microspheres has a significant effect on osteogenic differentiation.	Alginates	54-62	bone morphogenetic protein 6	Rattus norvegicus	43-48
21960023-15	2012	We conclude that sustained intrapericardial release of bFGF + VEGF from alginate beads attached to the epicardium facilitated vascular growth in the cryoinjured area.	Alginates	72-80	vascular endothelial growth factor A	Sus scrofa	62-66
22012415-0	2011	Design of a controlled release system of OP-1 and TGF-beta1 based in microparticles of sodium alginate and release characterization by HPLC-UV.	Alginates	87-102	transforming growth factor, beta 1	Rattus norvegicus	50-59
21999929-5	2011	Cryogenic-temperature transmission electron microscopy (cryo-TEM) and negative staining TEM revealed that the molecular interactions between alginate and ozarelix led to the formation of nanofibers.	Alginates	141-149	MFT2	Homo sapiens	61-64
21999929-5	2011	Cryogenic-temperature transmission electron microscopy (cryo-TEM) and negative staining TEM revealed that the molecular interactions between alginate and ozarelix led to the formation of nanofibers.	Alginates	141-149	MFT2	Homo sapiens	88-91
21928796-2	2011	It was found that membrane flux decline in the presence of both lysozyme and alginate was much more severe compared to that when there was only lysozyme or alginate in the feed solution.	Alginates	77-85	lysozyme	Homo sapiens	144-152
21872260-3	2011	In contrast, when 82-day-hydrolyzed sodium alginate, whose molecular weight became 7% of the molecular weight of the fresh sodium alginate, was used, porous microspheres with 6.5 times larger BET surface area were obtained.	Alginates	36-51	delta/notch like EGF repeat containing	Homo sapiens	192-195
21815803-0	2011	Fibroblast growth factor-2-overexpressing myoblasts encapsulated in alginate spheres increase proliferation, reduce apoptosis, induce adipogenesis, and enhance regeneration following skeletal muscle injury in rats.	Alginates	68-76	fibroblast growth factor 2	Rattus norvegicus	0-26
21815803-2	2011	In the present study, we tested the hypothesis that gene transfer of human FGF-2 via transplantation of genetically modified L8-myoblast encapsulated in alginate modulates the skeletal muscle recovery after crush injury in Wistar rats.	Alginates	153-161	fibroblast growth factor 2	Homo sapiens	75-80
21767847-0	2011	Magnetic alginate beads for Pb(II) ions removal from wastewater.	Alginates	9-17	submaxillary gland androgen regulated protein 3B	Homo sapiens	28-34
21656712-3	2011	To circumvent these limitations, we investigated the efficacy of alginate microencapsulation in developing an implantable vehicle for hMSC delivery.	Alginates	65-73	musculin	Homo sapiens	134-138
21682547-7	2011	Saos-2 cultured within alginate gels upregulated the osteoblast phenotypic marker genes RUNX2, collagen I (COL1A1) and bone sialoprotein (BSP), and ALP protein activity was highest in alginate gels cast with strontium ions.	Alginates	23-31	RUNX family transcription factor 2	Homo sapiens	88-93
21682547-7	2011	Saos-2 cultured within alginate gels upregulated the osteoblast phenotypic marker genes RUNX2, collagen I (COL1A1) and bone sialoprotein (BSP), and ALP protein activity was highest in alginate gels cast with strontium ions.	Alginates	23-31	collagen type I alpha 1 chain	Homo sapiens	107-113
21682547-7	2011	Saos-2 cultured within alginate gels upregulated the osteoblast phenotypic marker genes RUNX2, collagen I (COL1A1) and bone sialoprotein (BSP), and ALP protein activity was highest in alginate gels cast with strontium ions.	Alginates	23-31	integrin binding sialoprotein	Homo sapiens	119-136
21682547-7	2011	Saos-2 cultured within alginate gels upregulated the osteoblast phenotypic marker genes RUNX2, collagen I (COL1A1) and bone sialoprotein (BSP), and ALP protein activity was highest in alginate gels cast with strontium ions.	Alginates	23-31	integrin binding sialoprotein	Homo sapiens	138-141
21682547-7	2011	Saos-2 cultured within alginate gels upregulated the osteoblast phenotypic marker genes RUNX2, collagen I (COL1A1) and bone sialoprotein (BSP), and ALP protein activity was highest in alginate gels cast with strontium ions.	Alginates	23-31	alkaline phosphatase, placental	Homo sapiens	148-151
21928796-2	2011	It was found that membrane flux decline in the presence of both lysozyme and alginate was much more severe compared to that when there was only lysozyme or alginate in the feed solution.	Alginates	156-164	lysozyme	Homo sapiens	64-72
21928796-8	2011	The mixed alginate-lysozyme fouling could result in an initial enhancement in salt rejection.	Alginates	10-18	lysozyme	Homo sapiens	19-27
21492411-2	2011	Here, we report an alginate three-dimensional (3D) culture system for the expansion of CD34+ cells in cord blood mononuclear cells (CBMCs).	Alginates	19-27	CD34 molecule	Homo sapiens	87-91
21492411-9	2011	CONCLUSION: This study demonstrates a new and efficient method to amplify the CD34+ human cord blood hematopoietic stem/progenitor cells in a 3D alginate culture system ex vivo for extended periods while retaining the hematopoietic reconstruction capacity.	Alginates	145-153	CD34 molecule	Homo sapiens	78-82
21745508-7	2011	Importantly, BMP-2-loaded photocrosslinked HP-ALG hydrogels induced significantly more osteogenesis than BMP-2-loaded photocrosslinked unmodified alginate hydrogels, with 1.9-fold greater peripheral bone formation and 1.3-fold greater calcium content in the BMP-2-loaded photocrosslinked HP-ALG hydrogels compared to the BMP-2-loaded photocrosslinked unmodified alginate hydrogels after 8weeks implantation.	Alginates	146-154	bone morphogenetic protein 2	Homo sapiens	13-18
21656074-4	2011	The combined features of this unique alginate hydrogel, as a temporary extracellular matrix replacement and a depot for bio-molecules such as insulin-like growth factor-1 and hepatocyte growth factor, led to improvements in cardiac structure and function, as demonstrated by the biomaterial"s abilities to thicken the scar and prevent left-ventricular remodeling and dilatation.	Alginates	37-45	insulin-like growth factor 1	Rattus norvegicus	142-170
21745508-7	2011	Importantly, BMP-2-loaded photocrosslinked HP-ALG hydrogels induced significantly more osteogenesis than BMP-2-loaded photocrosslinked unmodified alginate hydrogels, with 1.9-fold greater peripheral bone formation and 1.3-fold greater calcium content in the BMP-2-loaded photocrosslinked HP-ALG hydrogels compared to the BMP-2-loaded photocrosslinked unmodified alginate hydrogels after 8weeks implantation.	Alginates	362-370	bone morphogenetic protein 2	Homo sapiens	13-18
21630432-8	2011	The adsorption had no significant effects on the permselective properties of the capsule but we found a strong increase of TNFalpha production by human peripheral blood mononuclear cells when exposed to alginate-beads treated with human peritoneal fluid.	Alginates	203-211	tumor necrosis factor	Homo sapiens	123-131
21699977-7	2011	Immunization studies in Balb/c mice by intradermal route demonstrated that incorporation of alginate elicited higher humoral and cellular immune responses leading to more balanced Th1/Th2 responses.	Alginates	92-100	negative elongation factor complex member C/D, Th1l	Mus musculus	180-183
21699977-7	2011	Immunization studies in Balb/c mice by intradermal route demonstrated that incorporation of alginate elicited higher humoral and cellular immune responses leading to more balanced Th1/Th2 responses.	Alginates	92-100	heart and neural crest derivatives expressed 2	Mus musculus	184-187
21699977-8	2011	Furthermore, administration of MP containing RGD-modified alginate showed evidence of cell targeting by enhancing immunogenicity of microparticles, in particular with regard to cellular responses such as IFN-gamma secretion and lymphoproliferation.	Alginates	58-66	interferon gamma	Mus musculus	204-213
21892805-3	2011	Therefore, we encapsulated SDF-1 into alginate microspheres and further incorporated these into an injectable collagen-based matrix in order to improve local delivery.	Alginates	38-46	C-X-C motif chemokine ligand 12	Homo sapiens	27-32
22020461-0	2011	RGDS-fuctionalized alginates improve the survival rate of encapsulated embryonic stem cells during cryopreservation.	Alginates	19-28	ral guanine nucleotide dissociation stimulator	Mus musculus	0-4
22020461-2	2011	In this investigation, mouse embryonic stem cells (mESCs) were encapsulated in arginine-glycine-aspartic acid-serine (RGDS)-coupled calcium alginates (1.2 percent, w/v), allowed to attach to the substratum and then cryopreserved in 10 percent (v/v) dimethyl sulfoxide (DMSO) solution at a slow cooling rate of 1 C per min.	Alginates	132-149	ral guanine nucleotide dissociation stimulator	Mus musculus	118-122
22020461-3	2011	RGDS coupling to alginate was confirmed by Transmission Fourier Transform Infra-Red spectroscopy (T-FTIR) and quantified by using ninhydrin-Ultraviolet/Visible light (ninhydrin-UV/VIS) assay.	Alginates	17-25	ral guanine nucleotide dissociation stimulator	Mus musculus	0-4
22020461-4	2011	Flow cytometry data showed that mESCs cryopreserved in RGDS-alginate beads had a higher expression of stem cell markers compared with cells cryopreserved in suspension or cells cryopreserved in unmodified alginates.	Alginates	60-68	ral guanine nucleotide dissociation stimulator	Mus musculus	55-59
22020461-4	2011	Flow cytometry data showed that mESCs cryopreserved in RGDS-alginate beads had a higher expression of stem cell markers compared with cells cryopreserved in suspension or cells cryopreserved in unmodified alginates.	Alginates	205-214	ral guanine nucleotide dissociation stimulator	Mus musculus	55-59
22020461-6	2011	It was shown that post-thaw cell survival rate was significantly higher for cells encapsulated in RGDS-modified alginate (93 +- 2 percent, mean and standard error) than those in suspension (52 +- 2 percent) or in unmodified alginates (62 +- 3 percent).	Alginates	112-120	ral guanine nucleotide dissociation stimulator	Mus musculus	98-102
22020461-6	2011	It was shown that post-thaw cell survival rate was significantly higher for cells encapsulated in RGDS-modified alginate (93 +- 2 percent, mean and standard error) than those in suspension (52 +- 2 percent) or in unmodified alginates (62 +- 3 percent).	Alginates	224-233	ral guanine nucleotide dissociation stimulator	Mus musculus	98-102
22020461-8	2011	Encapsulation in RGDS-alginate was optimized for peptide concentration, cryoprotective agent loading time and cooling rate.	Alginates	22-30	ral guanine nucleotide dissociation stimulator	Mus musculus	17-21
21652067-0	2011	Enhanced MSC chondrogenesis following delivery of TGF-beta3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo.	Alginates	65-73	transforming growth factor beta 3	Homo sapiens	50-59
21652067-3	2011	Here, we investigated the co-encapsulation of TGF-beta3 containing alginate microspheres with human MSCs in hyaluronic acid (HA) hydrogels towards the development of implantable constructs for cartilage repair.	Alginates	67-75	transforming growth factor beta 3	Homo sapiens	46-55
21652067-4	2011	TGF-beta3 encapsulated in alginate microspheres with nanofilm coatings showed significantly reduced initial burst release compared to uncoated microspheres, with release times extending up to 6 days.	Alginates	26-34	transforming growth factor beta 3	Homo sapiens	0-9
21652067-8	2011	To prevent this, the co-delivery of parathyroid hormone-related protein (PTHrP) with TGF-beta3 in alginate microspheres was pursued, resulting in partially reduced calcification.	Alginates	98-106	parathyroid hormone like hormone	Homo sapiens	36-71
21652067-8	2011	To prevent this, the co-delivery of parathyroid hormone-related protein (PTHrP) with TGF-beta3 in alginate microspheres was pursued, resulting in partially reduced calcification.	Alginates	98-106	parathyroid hormone like hormone	Homo sapiens	73-78
21652067-8	2011	To prevent this, the co-delivery of parathyroid hormone-related protein (PTHrP) with TGF-beta3 in alginate microspheres was pursued, resulting in partially reduced calcification.	Alginates	98-106	transforming growth factor beta 3	Homo sapiens	85-94
21341993-0	2011	Vascular endothelial growth factor release from alginate microspheres under simulated physiological compressive loading and the effect on human vascular endothelial cells.	Alginates	48-56	vascular endothelial growth factor A	Homo sapiens	0-34
21824923-6	2011	Next, we developed crosslinked albumin-alginate microcapsules that sequentially release fibroblast growth factor-2 and hepatocyte growth factor.	Alginates	39-47	fibroblast growth factor 2	Rattus norvegicus	88-114
21768378-6	2011	Alginate biosynthesis by laboratory and clinical isolates of mucoid P. aeruginosa is necessary and sufficient to attenuate NPR-1-mediated behavior and it suppresses C. elegans pathogen avoidance behavior.	Alginates	0-8	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	123-128
21400575-4	2011	Sox-9-engineered ASCs (ASCs/Sox-9) were induced for the chondrocyte-like cell differentiation by 3D cultured in alginate beads and TGF-beta3 for 2 weeks.	Alginates	112-120	SRY-box transcription factor 9	Homo sapiens	0-5
21521659-2	2011	We have previously shown that anisotropic alginate-based hydrogels with a defined capillary diameter (25 mum), which form via a self-organizing process driven by unidirectional diffusion of divalent cations into sodium alginate sols, promoted longitudinally oriented elongation of CNS axons in vitro and in vivo.	Alginates	42-50	latexin	Homo sapiens	105-108
21521659-2	2011	We have previously shown that anisotropic alginate-based hydrogels with a defined capillary diameter (25 mum), which form via a self-organizing process driven by unidirectional diffusion of divalent cations into sodium alginate sols, promoted longitudinally oriented elongation of CNS axons in vitro and in vivo.	Alginates	212-227	latexin	Homo sapiens	105-108
21521659-4	2011	Superimposing an alginate sol with Cu(2+), Sr(2+), or Zn(2+) ion containing solutions allowed the creation of hydrogels with capillaries 18, 25 and 55 mum in diameter, respectively.	Alginates	17-25	latexin	Homo sapiens	151-154
21258873-6	2011	Higher esterification activities were achieved when the lipase extract was immobilized in sodium alginate and activated coal.	Alginates	90-105	lipase	Ricinus communis	56-62
25788363-1	2011	This paper demonstrates a proof-of-concept approach for encapsulating the insulin and Fe3O4 nanoparticles into size-controllable alginate microcapsules utilizing the electrostatic droplets (ESD) technique.	Alginates	129-137	insulin	Homo sapiens	74-81
21341993-8	2011	In addition, the periodic compression applied on composites containing both HUVECs and VEGF/alginate microspheres promoted the expression of matrix metalloproteinases-2/9 in HUVECs.	Alginates	92-100	matrix metallopeptidase 2	Homo sapiens	141-170
21437788-6	2011	Studies of the ten batches of one grade of sodium alginate show that eta(app) of their solutions did not correlate with L(E) while tan delta was significantly, but minimally, correlated to L(E).	Alginates	43-58	endothelin receptor type A	Homo sapiens	69-72
21845746-9	2011	SCI mice treated with 10 % sodium alginate gel and mMSCs achieved higher score in BMS scale as well as higher expression of NF-200 compared with the untreated SCI group.	Alginates	27-42	neurofilament, heavy polypeptide	Mus musculus	124-130
21567289-7	2011	These insulin-producing cells were encapsulated in an alginate membrane to form capsules.	Alginates	54-62	insulin	Homo sapiens	6-13
21484183-0	2011	Encapsulation of eukaryotic cells in alginate microparticles: cell signaling by TNF-alpha through capsular structure of cystic fibrosis cells.	Alginates	37-45	tumor necrosis factor	Homo sapiens	80-89
21566437-0	2011	[Preventive effect of polaprezinc suspension dispersed in sodium alginate solution (P-AG) for stomatitis induced by Docetaxel/Cisplatin/Fluorouracil (DCF) chemotherapy in patients with head and neck cancer].	Alginates	58-73	phosphoprotein membrane anchor with glycosphingolipid microdomains 1	Homo sapiens	84-88
21337520-2	2011	After 3 d of culture, RGD-modified alginate hydrogels significantly stimulated FAK and integrin alpha1 gene expressions and vinculin expression in ASCs.	Alginates	35-43	protein tyrosine kinase 2	Homo sapiens	79-82
21337520-2	2011	After 3 d of culture, RGD-modified alginate hydrogels significantly stimulated FAK and integrin alpha1 gene expressions and vinculin expression in ASCs.	Alginates	35-43	integrin subunit alpha 1	Homo sapiens	87-102
21337520-2	2011	After 3 d of culture, RGD-modified alginate hydrogels significantly stimulated FAK and integrin alpha1 gene expressions and vinculin expression in ASCs.	Alginates	35-43	vinculin	Homo sapiens	124-132
21183950-4	2011	An in vitro study demonstrated the successful transfection of LM8 cells cultured in alginate beads by "naked" NF-kappaB decoy ODN and that the activation of NF-kappaB signaling was significantly suppressed.	Alginates	84-92	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	110-119
21384543-7	2011	The CPC modified with alginate provided the best results based on cell proliferation, ALP and collagen production, and osteogenic transcript increases (for ALP, type I collagen, BSP, and OP).	Alginates	22-30	ATHS	Homo sapiens	86-89
21384543-7	2011	The CPC modified with alginate provided the best results based on cell proliferation, ALP and collagen production, and osteogenic transcript increases (for ALP, type I collagen, BSP, and OP).	Alginates	22-30	ATHS	Homo sapiens	156-189
21437951-8	2011	Aminoguanidine significantly reversed the changes in alginate beads induced by IL-1beta treatment.	Alginates	53-61	interleukin 1 beta	Homo sapiens	79-87
21183950-6	2011	Furthermore, the transfection of "naked" NF-kappaB decoy ODN effectively suppressed pulmonary metastasis in an in vivo alginate bead transplantation model.	Alginates	119-127	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	41-50
21193068-7	2011	As shown by gelatine-zymography, MSC presented higher activity of MMP-2 when cultured within alginate functionalized with MMP-sensitive peptide, suggesting that the cell"s proteolytic phenotype was modulated by the matrix composition.	Alginates	93-101	matrix metallopeptidase 2	Homo sapiens	66-71
21836406-10	2011	CONCLUSION: The intravitreal application of beads containing alginate-encapsulated cells producing GLP-1 resulted in an intraocular production of GLP-1 with a significant increase in the intraocular GLP-1 concentration, without observed cytotoxic effects.	Alginates	61-69	glucagon	Rattus norvegicus	99-104
21836406-10	2011	CONCLUSION: The intravitreal application of beads containing alginate-encapsulated cells producing GLP-1 resulted in an intraocular production of GLP-1 with a significant increase in the intraocular GLP-1 concentration, without observed cytotoxic effects.	Alginates	61-69	glucagon	Rattus norvegicus	146-151
21836406-10	2011	CONCLUSION: The intravitreal application of beads containing alginate-encapsulated cells producing GLP-1 resulted in an intraocular production of GLP-1 with a significant increase in the intraocular GLP-1 concentration, without observed cytotoxic effects.	Alginates	61-69	glucagon	Rattus norvegicus	146-151
20864165-0	2011	An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects.	Alginates	3-11	myotrophin	Rattus norvegicus	36-49
21409753-4	2011	By delivering BMP-2 cDNA in an alginate hydrogel, a versatile formulation is developed.	Alginates	31-39	bone morphogenetic protein 2	Homo sapiens	14-19
21409753-8	2011	The protein levels were effective in inducing osteogenic differentiation in vitro, as seen by elevated alkaline phosphatase (ALP) production and in vivo, as demonstrated by the production of collagen I and osteocalcin in a mineralised alginate matrix.	Alginates	235-243	bone gamma-carboxyglutamate protein	Homo sapiens	206-217
21409753-9	2011	We conclude that BMP-2 cDNA incorporated in alginate hydrogel appears to be a promising new strategy for minimal-invasive delivery of growth factors in bone regeneration.	Alginates	44-52	bone morphogenetic protein 2	Homo sapiens	17-22
20889201-0	2011	The promotion of myocardial repair by the sequential delivery of IGF-1 and HGF from an injectable alginate biomaterial in a model of acute myocardial infarction.	Alginates	98-106	insulin-like growth factor 1	Rattus norvegicus	65-70
21159379-4	2011	Using this device, we demonstrated that (1) agarose-alginate mixture can be gelled thermally, thus an excellent candidate for forming multi-layered scaffolds for micropatterning embedded cells; (2) primary cortical neurons were cultured successfully for up to three weeks in the micropatterned multi-layered scaffold; (3) B27 concentration gradient enhanced neurite outgrowth.	Alginates	52-60	melanocortin 2 receptor accessory protein	Homo sapiens	322-325
20889201-0	2011	The promotion of myocardial repair by the sequential delivery of IGF-1 and HGF from an injectable alginate biomaterial in a model of acute myocardial infarction.	Alginates	98-106	hepatocyte growth factor	Rattus norvegicus	75-78
20864165-3	2011	In this study, we introduce a hybrid growth factor delivery system that consists of an electrospun nanofiber mesh tube for guiding bone regeneration combined with peptide-modified alginate hydrogel injected inside the tube for sustained growth factor release.	Alginates	180-188	myotrophin	Rattus norvegicus	237-250
20889201-2	2011	We hypothesized that the dual delivery of insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF) by injectable affinity-binding alginate biomaterial would maximize their therapeutic effects, leading to a more favorable course of tissue restoration after acute MI.	Alginates	145-153	insulin-like growth factor 1	Rattus norvegicus	42-70
20889201-2	2011	We hypothesized that the dual delivery of insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF) by injectable affinity-binding alginate biomaterial would maximize their therapeutic effects, leading to a more favorable course of tissue restoration after acute MI.	Alginates	145-153	insulin-like growth factor 1	Rattus norvegicus	72-77
20864165-10	2011	Overall, our results indicate that the hybrid alginate/nanofiber mesh system is a promising growth factor delivery strategy for the repair of challenging bone injuries.	Alginates	46-54	myotrophin	Rattus norvegicus	92-105
20889201-2	2011	We hypothesized that the dual delivery of insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF) by injectable affinity-binding alginate biomaterial would maximize their therapeutic effects, leading to a more favorable course of tissue restoration after acute MI.	Alginates	145-153	hepatocyte growth factor	Rattus norvegicus	83-107
20889201-2	2011	We hypothesized that the dual delivery of insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF) by injectable affinity-binding alginate biomaterial would maximize their therapeutic effects, leading to a more favorable course of tissue restoration after acute MI.	Alginates	145-153	hepatocyte growth factor	Rattus norvegicus	109-112
21056148-2	2010	The aim of this study was to examine the encapsulation and release of a novel chimeric form of fibroblast growth factor-1 (FGF-1) from the outer layer of alginate microcapsules.	Alginates	154-162	fibroblast growth factor 1	Homo sapiens	95-121
20889201-3	2011	A sequential release of IGF-1 followed by HGF was attained from affinity-binding alginate biomaterial, which also protected the proteins from proteolysis (shown by mass spectroscopy).	Alginates	81-89	insulin-like growth factor 1	Rattus norvegicus	24-29
20889201-3	2011	A sequential release of IGF-1 followed by HGF was attained from affinity-binding alginate biomaterial, which also protected the proteins from proteolysis (shown by mass spectroscopy).	Alginates	81-89	hepatocyte growth factor	Rattus norvegicus	42-45
20889201-5	2011	In a rat model of acute MI, an intramyocardial injection of the dual IGF-1/HGF affinity-bound alginate biomaterial preserved scar thickness, attenuated infarct expansion and reduced scar fibrosis after 4 weeks, concomitantly with increased angiogenesis and mature blood vessel formation at the infarct.	Alginates	94-102	hepatocyte growth factor	Rattus norvegicus	75-78
20889201-7	2011	The dual delivery of IGF-1 and HGF from affinity-binding alginate biomaterial represents a useful strategy to treat MI.	Alginates	57-65	insulin-like growth factor 1	Rattus norvegicus	21-26
20889201-7	2011	The dual delivery of IGF-1 and HGF from affinity-binding alginate biomaterial represents a useful strategy to treat MI.	Alginates	57-65	hepatocyte growth factor	Rattus norvegicus	31-34
22114497-4	2011	METHODS: PlGF-loaded chitosan-alginate nanoparticles were injected into an acute myocardial infarction model in rats (n = 10 per group).	Alginates	30-38	placental growth factor	Rattus norvegicus	9-13
22114497-10	2011	RESULTS: At 8 weeks after coronary ligation, hearts that were treated with PlGF-loaded chitosan-alginate nanoparticles had significant increases in left-ventricular function (P &lt; 0.01), vascular density (P &lt; 0.01), and in the serum level of the anti-inflammatory cytokine interleukin-10 (P &lt; 0.05).	Alginates	96-104	placental growth factor	Rattus norvegicus	75-79
22114497-10	2011	RESULTS: At 8 weeks after coronary ligation, hearts that were treated with PlGF-loaded chitosan-alginate nanoparticles had significant increases in left-ventricular function (P &lt; 0.01), vascular density (P &lt; 0.01), and in the serum level of the anti-inflammatory cytokine interleukin-10 (P &lt; 0.05).	Alginates	96-104	interleukin 10	Rattus norvegicus	278-292
20633323-3	2011	To demonstrate this principle, a cross-linked alginate film has been imprinted with bovine serum albumin (BSA) using aqueous biocompatible gelation methods.	Alginates	46-54	albumin	Homo sapiens	91-104
20699058-0	2011	Interactions between bovine serum albumin and oxidized sodium alginate in solution.	Alginates	55-70	albumin	Homo sapiens	28-41
20699058-1	2011	This paper focuses on the interactions between oxidized sodium alginate (OSA) and bovine serum albumin (BSA) at the molecular level with the purpose to provide basic information for optimizing the biological utilization and pharmaceutical applications of OSA.	Alginates	56-71	albumin	Homo sapiens	89-102
20942395-5	2010	Importantly, we show that tailor-made alginate constructs containing brain-derived neurotrophic factor or neurotrophin-3 differentially direct lineage fates of NPCs and may therefore be useful in treating a wide variety of injuries.	Alginates	38-46	brain derived neurotrophic factor	Homo sapiens	69-102
20942395-5	2010	Importantly, we show that tailor-made alginate constructs containing brain-derived neurotrophic factor or neurotrophin-3 differentially direct lineage fates of NPCs and may therefore be useful in treating a wide variety of injuries.	Alginates	38-46	neurotrophin 3	Homo sapiens	106-120
21686168-0	2011	Immobilization of glucose oxidase in alginate-chitosan microcapsules.	Alginates	37-45	hydroxyacid oxidase 1	Homo sapiens	18-33
21736520-0	2011	Influence of alginate cross-linking method on neurite response to microencapsulated neurotrophin-producing fibroblasts.	Alginates	13-21	brain derived neurotrophic factor	Homo sapiens	84-96
21736520-2	2011	Previously we showed that fibroblasts engineered to produce brain-derived neurotrophic factor (Fb/BDNF) microencapsulated in alginate survive, continue to grow and express bioactive BDNF.	Alginates	125-133	brain derived neurotrophic factor	Homo sapiens	60-93
21736520-2	2011	Previously we showed that fibroblasts engineered to produce brain-derived neurotrophic factor (Fb/BDNF) microencapsulated in alginate survive, continue to grow and express bioactive BDNF.	Alginates	125-133	brain derived neurotrophic factor	Homo sapiens	98-102
21736520-2	2011	Previously we showed that fibroblasts engineered to produce brain-derived neurotrophic factor (Fb/BDNF) microencapsulated in alginate survive, continue to grow and express bioactive BDNF.	Alginates	125-133	brain derived neurotrophic factor	Homo sapiens	182-186
21736520-3	2011	We here compared the effects of different alginate crosslinkers on dorsal root ganglia (DRG) neurite growth using alginate-encapsulated Fb/BDNF.	Alginates	114-122	brain derived neurotrophic factor	Homo sapiens	139-143
21736520-4	2011	Aqueous sodium alginate (+-Fb/BDNF) was contacted with different calcium salts, and used as substrate for DRG growth.	Alginates	8-23	brain derived neurotrophic factor	Homo sapiens	30-34
21736520-8	2011	This positive effect of alginate-encapsulated Fb/BDNF on neurite growth/guidance shows promise for enhanced regeneration and guidance of axons towards a specific target in the injured spinal cord.	Alginates	24-32	brain derived neurotrophic factor	Homo sapiens	49-53
21056148-2	2010	The aim of this study was to examine the encapsulation and release of a novel chimeric form of fibroblast growth factor-1 (FGF-1) from the outer layer of alginate microcapsules.	Alginates	154-162	fibroblast growth factor 1	Homo sapiens	123-128
21056148-3	2010	METHODS: Heparin-binding growth-associated molecule bound to FGF-1 (HB-GAM/FGF-1) was encapsulated in the outer layer of multilayered alginate microbeads constructed using varying alginate conditions.	Alginates	134-142	pleiotrophin	Homo sapiens	9-51
21056148-3	2010	METHODS: Heparin-binding growth-associated molecule bound to FGF-1 (HB-GAM/FGF-1) was encapsulated in the outer layer of multilayered alginate microbeads constructed using varying alginate conditions.	Alginates	134-142	fibroblast growth factor 1	Homo sapiens	61-66
21056148-3	2010	METHODS: Heparin-binding growth-associated molecule bound to FGF-1 (HB-GAM/FGF-1) was encapsulated in the outer layer of multilayered alginate microbeads constructed using varying alginate conditions.	Alginates	134-142	pleiotrophin	Homo sapiens	68-74
21056148-3	2010	METHODS: Heparin-binding growth-associated molecule bound to FGF-1 (HB-GAM/FGF-1) was encapsulated in the outer layer of multilayered alginate microbeads constructed using varying alginate conditions.	Alginates	134-142	fibroblast growth factor 1	Homo sapiens	75-80
21056148-3	2010	METHODS: Heparin-binding growth-associated molecule bound to FGF-1 (HB-GAM/FGF-1) was encapsulated in the outer layer of multilayered alginate microbeads constructed using varying alginate conditions.	Alginates	180-188	pleiotrophin	Homo sapiens	9-51
21056148-3	2010	METHODS: Heparin-binding growth-associated molecule bound to FGF-1 (HB-GAM/FGF-1) was encapsulated in the outer layer of multilayered alginate microbeads constructed using varying alginate conditions.	Alginates	180-188	fibroblast growth factor 1	Homo sapiens	61-66
21056148-3	2010	METHODS: Heparin-binding growth-associated molecule bound to FGF-1 (HB-GAM/FGF-1) was encapsulated in the outer layer of multilayered alginate microbeads constructed using varying alginate conditions.	Alginates	180-188	pleiotrophin	Homo sapiens	68-74
21056148-7	2010	CONCLUSIONS: The outer layer of multilayered alginate microbeads can be used for the encapsulation and long-term release of HB-GAM/FGF-1.	Alginates	45-53	pleiotrophin	Homo sapiens	124-130
21056148-7	2010	CONCLUSIONS: The outer layer of multilayered alginate microbeads can be used for the encapsulation and long-term release of HB-GAM/FGF-1.	Alginates	45-53	fibroblast growth factor 1	Homo sapiens	131-136
20941509-0	2010	17beta-estradiol reduces expression of MMP-1, -3, and -13 in human primary articular chondrocytes from female patients cultured in a three dimensional alginate system.	Alginates	151-159	matrix metallopeptidase 1	Homo sapiens	39-57
20725969-0	2010	Synthesis of multilayered alginate microcapsules for the sustained release of fibroblast growth factor-1.	Alginates	26-34	fibroblast growth factor 1	Homo sapiens	78-104
20688491-0	2010	Microcapsules of alginate/chitosan containing magnetic nanoparticles for controlled release of insulin.	Alginates	17-25	insulin	Homo sapiens	95-102
20688491-2	2010	The insulin beads were prepared by dripping a solution of sodium alginate containing insulin into a CaCl(2) solution.	Alginates	58-73	insulin	Homo sapiens	4-11
20688491-2	2010	The insulin beads were prepared by dripping a solution of sodium alginate containing insulin into a CaCl(2) solution.	Alginates	58-73	insulin	Homo sapiens	85-92
20688491-4	2010	Quantitative analysis revealed that insulin encapsulation depends on the initial protein content and 35% of insulin was entrapped by alginate beads for a protein concentration of 10 wt%.	Alginates	133-141	insulin	Homo sapiens	36-43
20688491-4	2010	Quantitative analysis revealed that insulin encapsulation depends on the initial protein content and 35% of insulin was entrapped by alginate beads for a protein concentration of 10 wt%.	Alginates	133-141	insulin	Homo sapiens	108-115
20688491-7	2010	The results suggest that the alginate/chitosan system containing magnetite nanoparticles is a promising system for clinical applications of controlled release of insulin in the presence of an oscillating magnetic field in a subcutaneous implant approach.	Alginates	29-37	insulin	Homo sapiens	162-169
20725969-4	2010	In this article, a technique is described for the generation of multilayered alginate microcapsules with an outer alginate layer that can be used for the delivery of FGF-1.	Alginates	77-85	fibroblast growth factor 1	Homo sapiens	166-171
20725969-4	2010	In this article, a technique is described for the generation of multilayered alginate microcapsules with an outer alginate layer that can be used for the delivery of FGF-1.	Alginates	114-122	fibroblast growth factor 1	Homo sapiens	166-171
20542332-0	2010	The effect of immobilized RGD peptide in macroporous alginate scaffolds on TGFbeta1-induced chondrogenesis of human mesenchymal stem cells.	Alginates	53-61	transforming growth factor beta 1	Homo sapiens	75-83
20528671-6	2010	Alginate-ASC suspension was painted onto PEGDA surface.	Alginates	0-8	PYD and CARD domain containing	Homo sapiens	9-12
20574984-8	2010	This novel alginate- HAP composite material could be used in bone tissue engineering as a scaffold material to deliver cells, and perhaps also biologically active molecules.	Alginates	11-19	reticulon 3	Homo sapiens	21-24
20205160-0	2010	Continuous supply of TGFbeta3 via adenoviral vector promotes type I collagen and viability of fibroblasts in alginate hydrogel.	Alginates	109-117	transforming growth factor beta 3	Homo sapiens	21-29
20542332-3	2010	In this study, the effects of RGD peptide immobilization onto macro-porous alginate scaffolds on TGF-beta1-induced hMSC chondrogenesis were evaluated.	Alginates	75-83	transforming growth factor beta 1	Homo sapiens	97-106
20542332-6	2010	By contrast, in the un-modified alginate scaffolds, the cells aggregated into compacted clusters resulting in lesser effects of TGF-beta1.	Alginates	32-40	transforming growth factor beta 1	Homo sapiens	128-137
20471413-1	2010	In the present work, a new particulate controlled release system was prepared, by coating alginate-g-PCL/Ca(2+) beads with chitosan.	Alginates	90-98	PHD finger protein 1	Homo sapiens	101-104
20957167-0	2010	Release profile and stability evaluation of optimized chitosan/alginate nanoparticles as EGFR antisense vector.	Alginates	63-71	epidermal growth factor receptor	Homo sapiens	89-93
20345284-0	2010	Preparation of chitosan/alginate/calcium complex microparticles loaded with lactoferrin and their efficacy on carrageenan-induced edema in rats.	Alginates	24-32	lactotransferrin	Rattus norvegicus	76-87
20345284-3	2010	METHOD: Chitosan/alginate/calcium complex microparticles containing LF at a high loading were prepared using alginate, LF, and calcium chloride at the ratio of 6:3:8 (w/w).	Alginates	17-25	lactotransferrin	Rattus norvegicus	68-70
20345284-10	2010	CONCLUSION: Chitosan/alginate/calcium complex microparticles are suggested to be useful for promotion of efficacy of LF at oral administration.	Alginates	21-29	lactotransferrin	Rattus norvegicus	117-119
20225253-2	2010	The aim of this study was to investigate the effect of incorporating mesoporous bioglass (MBG), nonmesoporous bioglass (BG), or hydroxyapatite (HAp) into alginate microspheres on their drug-loading and release properties.	Alginates	154-162	reticulon 3	Homo sapiens	144-147
20306542-7	2010	Following stimulation of human chondrocyte alginate cultures with conditioned media from human synovial fibroblasts derived from arthritis patients, microarray analysis verified the induction of genes related to cartilage destruction (like MMP10, -12) and inflammation (like IL6, -8 and chemokines).	Alginates	43-51	matrix metallopeptidase 10	Homo sapiens	240-245
20306542-7	2010	Following stimulation of human chondrocyte alginate cultures with conditioned media from human synovial fibroblasts derived from arthritis patients, microarray analysis verified the induction of genes related to cartilage destruction (like MMP10, -12) and inflammation (like IL6, -8 and chemokines).	Alginates	43-51	interleukin 6	Homo sapiens	275-278
26069552-7	2010	Lentiviral transduction with COMP resulted in elevated gene expression of COMP and increased COMP levels in the alginate bead and culture medium compared to untransfected cells.	Alginates	112-120	cartilage oligomeric matrix protein	Bos taurus	29-33
20225253-7	2010	DEX release from alginate microspheres correlated to the dissolution of MBG, BG, and HAp in PBS, and that the pH was an efficient factor in controlling the DEX release; a high pH resulted in greater DEX release, whereas a low pH delayed DEX release.	Alginates	17-25	reticulon 3	Homo sapiens	85-88
20685473-1	2010	A novel enzyme reactor with co-immobilization of beta-galactosidase and glucose oxidase in calcium alginate fiber (CAF) and amine modified nanosized mesoporous silica (AMNMS) was prepared which incorporate the adsorption and catalysis of AMNMS with the cage effect of the polymer to increase catalytic activity and stability of immobilized enzyme.	Alginates	91-107	galactosidase beta 1	Homo sapiens	49-67
20214469-5	2010	Additionally, 3D integrin engagement by RGD-modified alginate matrices increased IL-8 secretion independently of oxygen, whereas VEGF secretion was only moderately affected by cell-extracellular matrix interactions.	Alginates	53-61	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
20394813-0	2010	Effective protection and controlled release of insulin by cationic beta-cyclodextrin polymers from alginate/chitosan nanoparticles.	Alginates	99-107	insulin	Homo sapiens	47-54
20394813-1	2010	In an alginate/chitosan nanoparticle system, insulin was protected by forming complexes with cationic beta-cyclodextrin polymers (CPbetaCDs), which were synthesized from beta-cyclodextrin (beta-CD), epichlorohydrin (EP) and choline chloride (CC) through a one-step polycondensation.	Alginates	6-14	insulin	Homo sapiens	45-52
19618264-3	2010	Glucose oxidase (GOX) was encapsulated in alginate/chitosan hydrogel microspheres (ACMS-GOX).	Alginates	42-50	hydroxyacid oxidase 1, liver	Mus musculus	0-15
20519526-4	2010	To ensure long-term administration of CNTF in the brain, we used recombinant cells secreting CNTF encapsulated in alginate polymers.	Alginates	114-122	ciliary neurotrophic factor	Mus musculus	93-97
20206988-0	2010	The effects of controlled HGF delivery from an affinity-binding alginate biomaterial on angiogenesis and blood perfusion in a hindlimb ischemia model.	Alginates	64-72	hepatocyte growth factor	Rattus norvegicus	26-29
20206988-4	2010	When the HGF/alginate-sulfate bioconjugate was incorporated into alginate hydrogel, HGF release was sustained by a factor of 3, as compared to the release rate from non-modified hydrogel.	Alginates	13-21	hepatocyte growth factor	Rattus norvegicus	9-12
20206988-4	2010	When the HGF/alginate-sulfate bioconjugate was incorporated into alginate hydrogel, HGF release was sustained by a factor of 3, as compared to the release rate from non-modified hydrogel.	Alginates	13-21	hepatocyte growth factor	Mus musculus	84-87
20206988-6	2010	In vivo, an injectable form of the affinity-binding alginate system extended by 10-fold, as compared to a saline-treated group, retention of HGF in myocardial tissue when delivered immediately after myocardial infarction.	Alginates	52-60	hepatocyte growth factor	Rattus norvegicus	141-144
19618264-3	2010	Glucose oxidase (GOX) was encapsulated in alginate/chitosan hydrogel microspheres (ACMS-GOX).	Alginates	42-50	hydroxyacid oxidase 1, liver	Mus musculus	17-20
22716472-8	2010	Based on adhesion, loading and release characteristics, patches of Polycarbophil AA1 with K4M, K4MCR and sodium alginate were concluded to be suitable for further development.	Alginates	105-120	AA1	Homo sapiens	81-84
20348252-1	2010	The extracytoplasmic function sigma factor AlgU of Pseudomonas aeruginosa is responsible for alginate overproduction, leading to mucoidy and chronic infections of cystic fibrosis patients.	Alginates	93-101	RNA polymerase sigma factor AlgU	Pseudomonas aeruginosa PAO1	43-47
20303500-0	2010	Direct electrochemistry and electrocatalysis of myoglobin immobilized on Fe2O3 nanoparticle-sodium alginate-ionic liquid composite-modified electrode.	Alginates	92-107	myoglobin	Homo sapiens	48-57
20178130-9	2010	Subsequent culture of the dedifferentiated chondrocytes in 3-dimensional alginate beads rescued the chondrocyte phenotype and diminished the fragmentation of CD44.	Alginates	73-81	CD44 molecule (Indian blood group)	Homo sapiens	158-162
19959194-3	2010	Therefore, the specific aim of this research was quantify the effect of FGF-1 incorporation into alginate microbeads on neovascularization of such capsules in an in vivo rat transplant model.	Alginates	97-105	fibroblast growth factor 1	Rattus norvegicus	72-77
19959194-7	2010	CONCLUSIONS: These results indicate that alginate microbeads loaded with FGF-1 enhance local neovascularization around implanted microbeads.	Alginates	41-49	fibroblast growth factor 1	Rattus norvegicus	73-78
19578877-5	2010	The modified alginate conjugate was used for immobilization of bovine serum albumin in the presence of calcium chloride.	Alginates	13-21	albumin	Homo sapiens	70-83
20429683-1	2010	Polyphenol oxidase (PPO, EC 1.14.18.1) was isolated from artichoke head (Cynara scolymus L.) by using 0.1 M Tris-HCl buffer (pH 7.0), concentrated by (NH4)2SO4 precipitation, and immobilized in copper-alginate beads.	Alginates	194-209	protoporphyrinogen oxidase	Homo sapiens	0-18
20429683-1	2010	Polyphenol oxidase (PPO, EC 1.14.18.1) was isolated from artichoke head (Cynara scolymus L.) by using 0.1 M Tris-HCl buffer (pH 7.0), concentrated by (NH4)2SO4 precipitation, and immobilized in copper-alginate beads.	Alginates	194-209	protoporphyrinogen oxidase	Homo sapiens	20-23
20429683-0	2010	Optimization of polyphenol oxidase immobilization in copper alginate beads.	Alginates	53-68	protoporphyrinogen oxidase	Homo sapiens	16-34
20028218-7	2010	This study investigates the chondrogenic potential of recombinant human Nell-1 protein in a three-dimensional alginate hydrogel microenvironment containing rabbit chondrocytes.	Alginates	110-118	neural EGFL like 1	Homo sapiens	72-78
20110124-4	2010	We produced alginate microparticles that deliver VEGF and MCP-1 with distinct release kinetics and that can be integrated into a collagen/fibronectin (protein) gel construct for delivery of EC.	Alginates	12-20	vascular endothelial growth factor A	Mus musculus	49-53
19919044-0	2010	Effect of surface morphology and charge on the amount and conformation of fibrinogen adsorbed onto alginate/chitosan microcapsules.	Alginates	99-107	fibrinogen beta chain	Homo sapiens	74-84
20080298-0	2010	The effect of FGF-1 loaded alginate microbeads on neovascularization and adipogenesis in a vascular pedicle model of adipose tissue engineering.	Alginates	27-35	fibroblast growth factor 1	Rattus norvegicus	14-19
20080298-4	2010	The present study examines the ability of fibroblast growth factor (FGF-1) delivered from alginate microbeads to induce neovascularization and adipogenesis in type I collagen gels in a vascular pedicle model of adipose tissue engineering.	Alginates	90-98	fibroblast growth factor 1	Rattus norvegicus	68-73
20080298-9	2010	These results show that delivery of FGF-1 from alginate beads stimulated a more persistent neovascularization response than bolus FGF-1 both in vitro and in vivo.	Alginates	47-55	fibroblast growth factor 1	Rattus norvegicus	36-41
20225816-0	2010	Alginate-loaded liposomes can protect encapsulated alkaline phosphatase functionality when exposed to gastric pH.	Alginates	0-8	alkaline phosphatase, placental	Homo sapiens	51-71
20225816-3	2010	Alkaline phosphatase (ALP) was used as a model bioactive protein, which was encapsulated in alginate-loaded liposomes and conventional liposomes.	Alginates	92-100	alkaline phosphatase, placental	Homo sapiens	0-20
19963026-4	2010	Alginate microsphere-encapsulated VEGF (350 ng) was pre-included in small cylindrical chitosan sponges.	Alginates	0-8	vascular endothelial growth factor A	Oryctolagus cuniculus	34-38
20110124-4	2010	We produced alginate microparticles that deliver VEGF and MCP-1 with distinct release kinetics and that can be integrated into a collagen/fibronectin (protein) gel construct for delivery of EC.	Alginates	12-20	chemokine (C-C motif) ligand 2	Mus musculus	58-63
20131335-3	2010	METHODS: Plasmid-encoding rBD-2 was delivered to lungs in vivo using linear polyethylenimine at 48 h before challenging with seaweed alginate beads containing P. aeruginosa.	Alginates	133-141	defensin beta 4	Rattus norvegicus	26-31
20096671-5	2010	A small dose of BDNF delivered in a single infusion, or from a two-day sustained-release alginate implant, produced an antidepressant-like behavior, whereas the same dose delivered over a longer period of time to a larger tissue region did not produce antidepressant-like effects.	Alginates	89-97	brain-derived neurotrophic factor	Rattus norvegicus	16-20
19322877-7	2010	Furthermore, MC3T3-E1 preosteoblast cells exhibited the capacity to form bony tissue in as little as two and half weeks when mixed with DNA nanoparticles encoding for BMP-2 into the alginate hydrogels and injected subcutaneously in the backs of mice.	Alginates	182-190	bone morphogenetic protein 2	Mus musculus	167-172
19097150-0	2009	Sox9 expression of alginate-encapsulated chondrocytes is stimulated by low cell density.	Alginates	19-27	SRY-box transcription factor 9	Homo sapiens	0-4
20190401-2	2010	Both CS-SC and CS-PC (from 1 to 100 mug/ml) effectively suppressed the interleukin (IL)-1beta (10 ng/ml)-enhanced gene expression of aggrecanase-1/a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS)-4 and aggrecanase-2/ADAMTS-5 in articular chondrocytes embedded in alginate beads and synovial fibroblasts.	Alginates	291-299	interleukin 1 beta	Homo sapiens	71-93
20936184-0	2010	Induction by TNF-alpha of IL-6 and IL-8 in cystic fibrosis bronchial IB3-1 epithelial cells encapsulated in alginate microbeads.	Alginates	108-116	tumor necrosis factor	Homo sapiens	13-22
20936184-0	2010	Induction by TNF-alpha of IL-6 and IL-8 in cystic fibrosis bronchial IB3-1 epithelial cells encapsulated in alginate microbeads.	Alginates	108-116	interleukin 6	Homo sapiens	26-30
20936184-0	2010	Induction by TNF-alpha of IL-6 and IL-8 in cystic fibrosis bronchial IB3-1 epithelial cells encapsulated in alginate microbeads.	Alginates	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
19475466-0	2009	Synthetic alginate is a carrier of OP-1 for bone induction.	Alginates	10-18	bone morphogenetic protein 7	Homo sapiens	35-39
19475466-3	2009	We examined alginate, an approved biomaterial for human use, as a carrier for BMP-7.	Alginates	12-20	bone morphogenetic protein 7	Homo sapiens	78-83
19725071-0	2009	p38 MAPK mediated in compressive stress-induced chondrogenesis of rat bone marrow MSCs in 3D alginate scaffolds.	Alginates	93-101	mitogen activated protein kinase 14	Rattus norvegicus	0-3
19814590-4	2010	Clusterin secreted by superficial, middle, and deep zones equine chondrocytes was immunolocalized in cytospins of alginate cultured superficial, middle, and deep zones equine chondrocytes.	Alginates	114-122	clusterin	Equus caballus	0-9
19926128-3	2010	Alginate-VEGF(165)/P(DL)LA-BMP-2 scaffolds were fabricated using a supercritical CO(2) mixing technique and an alginate entrapment protocol.	Alginates	0-8	vascular endothelial growth factor A	Homo sapiens	9-13
19926128-6	2010	The alginate-VEGF(165)/P(DL)LA-BMP-2+HBMSC group showed a significant increase in the quantity of regenerated bone compared to the alginate-VEGF(165)/P(DL)LA-BMP-2 and alginate/P(DL)LA groups respectively in a critical sized femur defect study as indices measured by microCT.	Alginates	4-12	vascular endothelial growth factor A	Homo sapiens	13-17
19926128-6	2010	The alginate-VEGF(165)/P(DL)LA-BMP-2+HBMSC group showed a significant increase in the quantity of regenerated bone compared to the alginate-VEGF(165)/P(DL)LA-BMP-2 and alginate/P(DL)LA groups respectively in a critical sized femur defect study as indices measured by microCT.	Alginates	4-12	bone morphogenetic protein 2	Homo sapiens	31-36
19926128-6	2010	The alginate-VEGF(165)/P(DL)LA-BMP-2+HBMSC group showed a significant increase in the quantity of regenerated bone compared to the alginate-VEGF(165)/P(DL)LA-BMP-2 and alginate/P(DL)LA groups respectively in a critical sized femur defect study as indices measured by microCT.	Alginates	4-12	vascular endothelial growth factor A	Homo sapiens	140-144
19926128-6	2010	The alginate-VEGF(165)/P(DL)LA-BMP-2+HBMSC group showed a significant increase in the quantity of regenerated bone compared to the alginate-VEGF(165)/P(DL)LA-BMP-2 and alginate/P(DL)LA groups respectively in a critical sized femur defect study as indices measured by microCT.	Alginates	4-12	bone morphogenetic protein 2	Homo sapiens	158-163
19926128-6	2010	The alginate-VEGF(165)/P(DL)LA-BMP-2+HBMSC group showed a significant increase in the quantity of regenerated bone compared to the alginate-VEGF(165)/P(DL)LA-BMP-2 and alginate/P(DL)LA groups respectively in a critical sized femur defect study as indices measured by microCT.	Alginates	131-139	vascular endothelial growth factor A	Homo sapiens	140-144
19926128-6	2010	The alginate-VEGF(165)/P(DL)LA-BMP-2+HBMSC group showed a significant increase in the quantity of regenerated bone compared to the alginate-VEGF(165)/P(DL)LA-BMP-2 and alginate/P(DL)LA groups respectively in a critical sized femur defect study as indices measured by microCT.	Alginates	131-139	vascular endothelial growth factor A	Homo sapiens	140-144
19926128-7	2010	Histological examination confirmed significant new endochondral bone matrix in the HBMSC seeded alginate-VEGF(165)/P(DL)LA-BMP-2 defect group in comparison to the other groups.	Alginates	96-104	vascular endothelial growth factor A	Homo sapiens	105-109
19950204-7	2010	BMP-7 in the presence of TGF-beta3 induced superior chondrocytic proteoglycan accumulation, type II collagen, and SOX9 protein expression in alginate and pellet cultures compared to either factor alone.	Alginates	141-149	bone morphogenetic protein 7	Homo sapiens	0-5
19950204-7	2010	BMP-7 in the presence of TGF-beta3 induced superior chondrocytic proteoglycan accumulation, type II collagen, and SOX9 protein expression in alginate and pellet cultures compared to either factor alone.	Alginates	141-149	transforming growth factor beta 3	Homo sapiens	25-34
19718653-1	2010	In situ growth of gold nanoparticles (Au NPs) was performed in an alginate gel matrix co-encapsulating Au NP seeds and glucose oxidase (GOx) for the development of a glucose-sensing platform.	Alginates	66-74	hydroxyacid oxidase 1	Homo sapiens	119-134
19718653-1	2010	In situ growth of gold nanoparticles (Au NPs) was performed in an alginate gel matrix co-encapsulating Au NP seeds and glucose oxidase (GOx) for the development of a glucose-sensing platform.	Alginates	66-74	hydroxyacid oxidase 1	Homo sapiens	136-139
19995484-0	2010	Continuous delivery of stromal cell-derived factor-1 from alginate scaffolds accelerates wound healing.	Alginates	58-66	C-X-C motif chemokine ligand 12	Homo sapiens	23-52
19995484-4	2010	Our study utilized an alginate hydrogel patch to deliver stromal cell-derived factor-1 (SDF-1), a naturally occurring chemokine that is rapidly overexpressed in response to tissue injury, to assess the potential effects SDF-1 therapy on wound closure rates and scar formation.	Alginates	22-30	C-X-C motif chemokine ligand 12	Homo sapiens	57-86
19995484-5	2010	Alginate patches were loaded with either purified recombinant human SDF-1 protein or plasmid expressing SDF-1 and the kinetics of SDF-1 release were measured both in vitro and in vivo in mice.	Alginates	0-8	C-X-C motif chemokine ligand 12	Homo sapiens	68-73
19995484-5	2010	Alginate patches were loaded with either purified recombinant human SDF-1 protein or plasmid expressing SDF-1 and the kinetics of SDF-1 release were measured both in vitro and in vivo in mice.	Alginates	0-8	C-X-C motif chemokine ligand 12	Homo sapiens	104-109
19995484-5	2010	Alginate patches were loaded with either purified recombinant human SDF-1 protein or plasmid expressing SDF-1 and the kinetics of SDF-1 release were measured both in vitro and in vivo in mice.	Alginates	0-8	C-X-C motif chemokine ligand 12	Homo sapiens	104-109
19165782-5	2010	Protein-loaded alginate-chitosan microcapsules of approximately 20 mum in diameter were prepared by an emulsion-internal gelation-polyelectrolyte coating method.	Alginates	15-23	latexin	Homo sapiens	67-70
19686786-0	2009	Alginate encapsulation technology supports embryonic stem cells differentiation into insulin-producing cells.	Alginates	0-8	insulin	Homo sapiens	85-92
19686786-1	2009	This work investigates an application of the alginate encapsulation technology to the differentiation of embryonic stem (ES) cells into insulin-producing cells.	Alginates	45-53	insulin	Homo sapiens	136-143
19686786-6	2009	The functionality of the encapsulated and differentiated cells was confirmed by their insulin production capability, whereby on glucose challenge the insulin production by the cells differentiated within alginate beads was found to be statistically significantly higher than for the cells from conventional two-dimensional differentiation system.	Alginates	204-212	insulin	Homo sapiens	86-93
19686786-6	2009	The functionality of the encapsulated and differentiated cells was confirmed by their insulin production capability, whereby on glucose challenge the insulin production by the cells differentiated within alginate beads was found to be statistically significantly higher than for the cells from conventional two-dimensional differentiation system.	Alginates	204-212	insulin	Homo sapiens	150-157
19097150-3	2009	Here we investigated, whether the cell concentration of alginate encapsulated chondrocytes influences the Sox9 expression.	Alginates	56-64	SRY-box transcription factor 9	Homo sapiens	106-110
19952530-3	2009	The obtained chitosan-coated alginate/calcium complex microparticles (Ch/Al/Ca-MP) showed almost uniform size of 1-2 microm and a spherical shape with a non-smooth surface.	Alginates	29-37	cathelicidin antimicrobial peptide	Homo sapiens	76-81
20005389-0	2009	Novel sulfated glucomannan-barium-alginate microcapsules in islet transplantation: significantly decreased the secretion of monocyte chemotactic protein 1 and improved the activity of islet in rats.	Alginates	27-42	C-C motif chemokine ligand 2	Rattus norvegicus	124-154
19709739-3	2009	In this study we have shown by means of the Thiazolyl blue (MTT) assay and immuno-staining for proliferating cell nuclear antigen (PCNA) that encapsulating fibroblasts in 2% and 5%w/v calcium-alginate at a density of 7.5 x 10(5)cells/ml as uniformly dispersed entities, enabled cells to maintain viability and caused a reversible mitotic inhibition.	Alginates	184-200	proliferating cell nuclear antigen	Homo sapiens	95-129
19456239-6	2009	In subsequent alginate bead culture with human serum or transforming growth factor beta1 and insulin-transferrin-selenium-linoleic acid-bovine serum albumin, redifferentiation was enhanced with increased proteoglycan and collagen type II production.	Alginates	14-22	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	83-88
20023235-0	2009	The effects of alginate encapsulation on NIT-1 insulinoma cells: viability, growth and insulin secretion.	Alginates	15-23	nitrilase 1	Mus musculus	41-46
20023235-4	2009	For this purpose, cell growth and dynamics of insulin release of NIT-1 cells entrapped in alginate capsules compared with those exhibited by free NIT-1 cells were investigated by means of growth curves, assays, Trypan blue staining and ELISA test.	Alginates	90-98	nitrilase 1	Mus musculus	65-70
20023235-5	2009	All investigations performed allowed us to conclude that alginate-entrapped NIT-1 cells maintain their growth features and secretory functions although with some important differences.	Alginates	57-65	nitrilase 1	Mus musculus	76-81
19631739-1	2009	This paper presents the development of new pH-sensitive, amphiphilic and biocompatible hydrogels based on alginate-g-PCL, cross-linked with calcium ions to form beads, prepared for controlled delivery of poorly water-soluble drug.	Alginates	106-114	PHD finger protein 1	Homo sapiens	117-120
19631739-4	2009	In both media, rates of swelling were lower for beads based on amphiphilic derivatives than for alginate/Ca2+ ones due to the hydrophobic PCL grafts, and decreased when hydrophobic character increased.	Alginates	96-104	PHD finger protein 1	Homo sapiens	138-141
19631739-6	2009	The drug was protected in acidic fluid (only 14-20% of release for alginate-g-PCL hydrogel against 35% of release for alginate hydrogel during 350 min).	Alginates	67-76	PHD finger protein 1	Homo sapiens	78-81
19631739-6	2009	The drug was protected in acidic fluid (only 14-20% of release for alginate-g-PCL hydrogel against 35% of release for alginate hydrogel during 350 min).	Alginates	67-75	PHD finger protein 1	Homo sapiens	78-81
19631739-8	2009	PCL leads to decrease in the release kinetics in SIF (2h for alginate-g-PCL/Ca2+ beads against 1h for alginate/Ca2+ beads).	Alginates	61-69	PHD finger protein 1	Homo sapiens	0-3
19631739-8	2009	PCL leads to decrease in the release kinetics in SIF (2h for alginate-g-PCL/Ca2+ beads against 1h for alginate/Ca2+ beads).	Alginates	61-69	PHD finger protein 1	Homo sapiens	72-75
19631739-8	2009	PCL leads to decrease in the release kinetics in SIF (2h for alginate-g-PCL/Ca2+ beads against 1h for alginate/Ca2+ beads).	Alginates	102-110	PHD finger protein 1	Homo sapiens	0-3
19426107-0	2009	Addition of hyaluronic acid to alginate embedded chondrocytes interferes with insulin-like growth factor-1 signaling in vitro and in vivo.	Alginates	31-39	insulin-like growth factor 1	Mus musculus	78-106
19426107-7	2009	In vitro and in vivo data showed that increasing the concentration of HA in an alginate hydrogel can decrease chondrocyte IGF-1 expression.	Alginates	79-87	insulin-like growth factor 1	Mus musculus	122-127
19657054-5	2009	Primary human articular chondrocytes isolated from osteoarthritic cartilage at passage 2-4 showed significantly raised SOX9 mRNA levels when exposed to hyperosmotic conditions for 5 h. The effect was strongest and most reproducible when actin stress fibers were disrupted by the Rho effector kinase inhibitor Y27632, or by culturing the cells within alginate beads.	Alginates	350-358	SRY-box transcription factor 9	Homo sapiens	119-123
20137423-1	2009	OBJECTIVE: To detect the release of endostatin in microcapsules of calcium alginate gel by emulsification-internal gelatification technology, to observe the distribution of Endostatin microcapsules in the eye by periocular injection and biocompatibility.	Alginates	67-83	collagen, type XVIII, alpha 1	Mus musculus	36-46
20137423-2	2009	METHODS: The calcium alginate gel microcapsules encapsulating endostatin were prepared by emulsification-internal gelatification technology, the release of endostatin in microcapsules in vitro was examined by uv-Spectrophotometry.	Alginates	13-29	collagen, type XVIII, alpha 1	Mus musculus	62-72
19657146-2	2009	Overexpression of a catalytically active form of HtrA1, but not an active site mutant (S328A), caused a marked reduction in proteoglycan content in chondrocyte-seeded alginate cultures.	Alginates	167-175	HtrA serine peptidase 1	Homo sapiens	49-54
19657146-3	2009	Aggrecan degradation fragments were detected in conditioned media from the alginate cultures overexpressing active HtrA1.	Alginates	75-83	HtrA serine peptidase 1	Homo sapiens	115-120
19631637-6	2009	Exogenous VEGF-A, delivered by high-expressing VEGF-A-LacZ vessels or by rhVEGF-A/alginate spheres, increased sympathetic neurite outgrowth while exogenous rhSema3A/Fc decreased neurite outgrowth.	Alginates	82-90	vascular endothelial growth factor A	Homo sapiens	10-16
19683810-8	2009	It was concluded that the CBD-RGD-alginate culture system promoted the chondrogenesis of mesenchymal stem cells coordinated with TGF-beta3 induction in an RGD dose-dependent manner.	Alginates	34-42	transforming growth factor beta 3	Homo sapiens	129-138
19470758-2	2009	Culture of dedifferentiated chondrocytes in alginate gel induces a precipitous loss of RhoA protein and a loss of stress fibers concomitant with the reexpression of the chondrocyte differentiation program.	Alginates	44-52	ras homolog family member A	Homo sapiens	87-91
19508892-3	2009	Designed nanoparticles consisting of calcium crosslinked alginate, dextran sulfate, poloxamer 188 and chitosan followed by an outermost coating of albumin are described as multilayer complex retaining insulin within the nanoparticle.	Alginates	57-65	insulin	Homo sapiens	201-208
19555698-4	2009	Alginate microbeads were synthesized to release active FGF-1 for three weeks.	Alginates	0-8	fibroblast growth factor 1	Rattus norvegicus	55-60
19644865-6	2009	The expression of the first group of antigens (CD44, CD58, CD81, CD90, CD105, and CD166) was decreased reversibly by the 3-D alginate culture and irreversibly in the presence of TGFbeta3, except for CD81, which showed reversible changes regardless of TGFbeta3.	Alginates	125-133	CD44 molecule (Indian blood group)	Homo sapiens	47-51
19644865-6	2009	The expression of the first group of antigens (CD44, CD58, CD81, CD90, CD105, and CD166) was decreased reversibly by the 3-D alginate culture and irreversibly in the presence of TGFbeta3, except for CD81, which showed reversible changes regardless of TGFbeta3.	Alginates	125-133	CD58 molecule	Homo sapiens	53-57
19644865-6	2009	The expression of the first group of antigens (CD44, CD58, CD81, CD90, CD105, and CD166) was decreased reversibly by the 3-D alginate culture and irreversibly in the presence of TGFbeta3, except for CD81, which showed reversible changes regardless of TGFbeta3.	Alginates	125-133	CD81 molecule	Homo sapiens	59-63
19644865-6	2009	The expression of the first group of antigens (CD44, CD58, CD81, CD90, CD105, and CD166) was decreased reversibly by the 3-D alginate culture and irreversibly in the presence of TGFbeta3, except for CD81, which showed reversible changes regardless of TGFbeta3.	Alginates	125-133	Thy-1 cell surface antigen	Homo sapiens	65-69
19423762-5	2009	Wounded mouse ovaries embedded into an alginate hydrogel matrix have normal OSE cells as demonstrated by expression of cytokeratin 8, vimentin, N-cadherin, and a lack of E-cadherin.	Alginates	39-47	keratin 8	Mus musculus	119-132
19423762-5	2009	Wounded mouse ovaries embedded into an alginate hydrogel matrix have normal OSE cells as demonstrated by expression of cytokeratin 8, vimentin, N-cadherin, and a lack of E-cadherin.	Alginates	39-47	vimentin	Mus musculus	134-142
19423762-5	2009	Wounded mouse ovaries embedded into an alginate hydrogel matrix have normal OSE cells as demonstrated by expression of cytokeratin 8, vimentin, N-cadherin, and a lack of E-cadherin.	Alginates	39-47	cadherin 2	Mus musculus	144-154
19685212-1	2009	PURPOSE: This work focused on the characterization and in vitro/in vivo evaluation of an alginate/chitosan microsphere (ACMS) formulation of glucose oxidase (GOX) for the locoregional delivery of reactive oxygen species for the treatment of solid tumors.	Alginates	89-97	hydroxyacid oxidase 1, liver	Mus musculus	141-156
19685212-1	2009	PURPOSE: This work focused on the characterization and in vitro/in vivo evaluation of an alginate/chitosan microsphere (ACMS) formulation of glucose oxidase (GOX) for the locoregional delivery of reactive oxygen species for the treatment of solid tumors.	Alginates	89-97	hydroxyacid oxidase 1, liver	Mus musculus	158-161
19685212-5	2009	RESULTS: GOX was loaded into calcium alginate (CaAlg) gel beads via electrostatic interaction and the CaAlg-GOX-chitosan complexation likely stabilized GOX.	Alginates	29-45	hydroxyacid oxidase 1, liver	Mus musculus	9-12
19481797-5	2009	Further, delivery of an appropriate combination of DAPT and VEGF from an injectable alginate hydrogel system into ischemic hindlimbs led to a faster recovery of blood flow than VEGF or DAPT alone; perfusion levels reached 80% of the normal level by week 4 with combined DAPT and VEGF delivery.	Alginates	84-92	vascular endothelial growth factor A	Homo sapiens	60-64
19442724-0	2009	VEGF-controlled release within a bone defect from alginate/chitosan/PLA-H scaffolds.	Alginates	50-58	vascular endothelial growth factor A	Rattus norvegicus	0-4
19442724-2	2009	For this reason, we developed a composite (alginate/chitosan/PLA-H) system that controls the release kinetics of incorporated VEGF to enhance neovascularization in bone healing.	Alginates	43-51	vascular endothelial growth factor A	Rattus norvegicus	126-130
19442724-4	2009	VEGF was firstly encapsulated in alginate microspheres.	Alginates	33-41	vascular endothelial growth factor A	Rattus norvegicus	0-4
19644865-6	2009	The expression of the first group of antigens (CD44, CD58, CD81, CD90, CD105, and CD166) was decreased reversibly by the 3-D alginate culture and irreversibly in the presence of TGFbeta3, except for CD81, which showed reversible changes regardless of TGFbeta3.	Alginates	125-133	activated leukocyte cell adhesion molecule	Homo sapiens	82-87
19157703-0	2009	Co(II) removal by magnetic alginate beads containing Cyanex 272.	Alginates	27-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
19545119-4	2009	Insulin, taken as a model peptide, was associated to CS-TPP-ALG nanoparticles with efficiencies in the range of ~41 to ~52%, irrespective of the M(w) of the ALG incorporated in the formulation.	Alginates	60-63	insulin	Oryctolagus cuniculus	0-7
19157703-1	2009	In this study, a series of batch experiments is conducted to investigate the ability of magnetic alginate beads containing Cyanex 272 to remove Co(II) ions from aqueous solutions.	Alginates	97-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-150
18950289-0	2009	BMP-2 enhances TGF-beta3-mediated chondrogenic differentiation of human bone marrow multipotent mesenchymal stromal cells in alginate bead culture.	Alginates	125-133	bone morphogenetic protein 2	Homo sapiens	0-5
19450670-2	2009	In this study, three-dimensional scaffolds prepared from the polyelectrolyte complexes (PEC) of chitosan and alginate were developed for the delivery of bFGF.	Alginates	109-117	fibroblast growth factor 2	Homo sapiens	153-157
19450670-3	2009	The bFGF-binding efficiency of the chitosan-alginate PEC scaffold, after being conjugated with high concentration of heparin (83.6 microg/mg scaffold), was increased up to 15 times higher than that of original scaffold (65.6 ng bFGF/mg scaffold vs. 4.5 ng bFGF/mg scaffold).	Alginates	44-52	fibroblast growth factor 2	Homo sapiens	4-8
19450670-3	2009	The bFGF-binding efficiency of the chitosan-alginate PEC scaffold, after being conjugated with high concentration of heparin (83.6 microg/mg scaffold), was increased up to 15 times higher than that of original scaffold (65.6 ng bFGF/mg scaffold vs. 4.5 ng bFGF/mg scaffold).	Alginates	44-52	fibroblast growth factor 2	Homo sapiens	228-232
19450670-3	2009	The bFGF-binding efficiency of the chitosan-alginate PEC scaffold, after being conjugated with high concentration of heparin (83.6 microg/mg scaffold), was increased up to 15 times higher than that of original scaffold (65.6 ng bFGF/mg scaffold vs. 4.5 ng bFGF/mg scaffold).	Alginates	44-52	fibroblast growth factor 2	Homo sapiens	228-232
19450670-7	2009	This study shows that a novel bFGF delivery system using the heparin-functionalized chitosan-alginate PEC scaffold exhibits controllable, long-term release of bFGF and could prevent the growth factor from inactivation.	Alginates	93-101	fibroblast growth factor 2	Homo sapiens	30-34
19450670-7	2009	This study shows that a novel bFGF delivery system using the heparin-functionalized chitosan-alginate PEC scaffold exhibits controllable, long-term release of bFGF and could prevent the growth factor from inactivation.	Alginates	93-101	fibroblast growth factor 2	Homo sapiens	159-163
18839189-5	2009	At the same time using mosaicplasty to repair the defects on the medial femoral condyle, the dead space between the cylindrical grafts were filled with the gels of hTGF-beta1 gene transduced BMSCs in alginate.	Alginates	200-208	transforming growth factor beta 1	Homo sapiens	164-174
19307458-5	2009	The IL-1 beta-induced reduction in PG synthesis and proliferation of chondrocytes cultured in alginate were counteracted by the CAT fraction at a concentration of 10 microg/ml.	Alginates	94-102	interleukin 1 beta	Bos taurus	4-13
19327822-2	2009	In the present paper, alginate-poly-l-lysine-alginate (APA) microcapsules containing erythropoietin (Epo)-secreting C(2)C(12) myoblasts were elaborated, characterized and tested both in vitro and in vivo.	Alginates	22-30	erythropoietin	Mus musculus	85-99
19327822-2	2009	In the present paper, alginate-poly-l-lysine-alginate (APA) microcapsules containing erythropoietin (Epo)-secreting C(2)C(12) myoblasts were elaborated, characterized and tested both in vitro and in vivo.	Alginates	22-30	erythropoietin	Mus musculus	101-104
19525490-8	2009	Fluorogenic assays with CYP3A4, CYP2C9, and CYP2D6 on the alginate microarrays exhibited Z" factors ranging from 0.75 to 0.85, sensitive detection of inhibitory compounds, and reactivity comparable to that in solution, thereby demonstrating the reliability and accuracy of the microarray platform.	Alginates	58-66	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	32-38
19525490-8	2009	Fluorogenic assays with CYP3A4, CYP2C9, and CYP2D6 on the alginate microarrays exhibited Z" factors ranging from 0.75 to 0.85, sensitive detection of inhibitory compounds, and reactivity comparable to that in solution, thereby demonstrating the reliability and accuracy of the microarray platform.	Alginates	58-66	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	44-50
19527480-7	2009	The expressions of transforming growth factor-beta1, fibronectin, and vascular endothelial growth factor were significantly decreased in the alginate-treated group compared with the control group, while the expression of collagen-I was increased in the alginate-treated group, as indicated by Western blotting and immunohistochemical staining.	Alginates	141-149	transforming growth factor, beta 1	Rattus norvegicus	19-51
19527480-7	2009	The expressions of transforming growth factor-beta1, fibronectin, and vascular endothelial growth factor were significantly decreased in the alginate-treated group compared with the control group, while the expression of collagen-I was increased in the alginate-treated group, as indicated by Western blotting and immunohistochemical staining.	Alginates	141-149	fibronectin 1	Rattus norvegicus	53-64
19527480-7	2009	The expressions of transforming growth factor-beta1, fibronectin, and vascular endothelial growth factor were significantly decreased in the alginate-treated group compared with the control group, while the expression of collagen-I was increased in the alginate-treated group, as indicated by Western blotting and immunohistochemical staining.	Alginates	253-261	transforming growth factor, beta 1	Rattus norvegicus	19-51
19527480-9	2009	The results from the present study indicate that the effect of alginate on wound healing may involve biological mechanisms associated with the expression of transforming growth factor-beta1, fibronectin, vascular endothelial growth factor, and collagen-I.	Alginates	63-71	transforming growth factor, beta 1	Rattus norvegicus	157-189
19527480-9	2009	The results from the present study indicate that the effect of alginate on wound healing may involve biological mechanisms associated with the expression of transforming growth factor-beta1, fibronectin, vascular endothelial growth factor, and collagen-I.	Alginates	63-71	fibronectin 1	Rattus norvegicus	191-202
19348419-2	2009	Hydroxyapatite (HAp) was incorporated into an alginate solution and internal gelling was induced by addition of slowly acid hydrolyzing d-gluconic acid delta-lactone (GDL) for the direct release of calcium ions from HAp.	Alginates	46-54	retinoic acid receptor beta	Homo sapiens	16-19
18633128-4	2009	The regulation of MIA production was studied in vivo in rheumatoid arthritis (RA) (n = 37) and spondyloarthritis (SpA) (n = 30) synovial fluid (SF), and in vitro in alginate embedded human chondrocytes.	Alginates	165-173	MIA SH3 domain containing	Homo sapiens	18-21
19479861-5	2009	RESULTS: When maintained in an alginate matrix, chondrocytes isolated from the femoral heads of patients with AS constitutively expressed type II collagen and CD80.	Alginates	31-39	CD80 molecule	Homo sapiens	159-163
18950289-0	2009	BMP-2 enhances TGF-beta3-mediated chondrogenic differentiation of human bone marrow multipotent mesenchymal stromal cells in alginate bead culture.	Alginates	125-133	transforming growth factor beta 3	Homo sapiens	15-24
18950289-2	2009	Human BM MSCs encapsulated in alginate beads were induced to differentiate in serum-free medium containing BMP-2 and TGF-beta3.	Alginates	30-38	bone morphogenetic protein 2	Homo sapiens	107-112
18950289-2	2009	Human BM MSCs encapsulated in alginate beads were induced to differentiate in serum-free medium containing BMP-2 and TGF-beta3.	Alginates	30-38	transforming growth factor beta 3	Homo sapiens	117-126
18950289-9	2009	The combination of BMP-2 and TGF-beta3 in alginate culture is superior to the standard differentiation method using TGF-beta alone.	Alginates	42-50	bone morphogenetic protein 2	Homo sapiens	19-24
18950289-9	2009	The combination of BMP-2 and TGF-beta3 in alginate culture is superior to the standard differentiation method using TGF-beta alone.	Alginates	42-50	transforming growth factor beta 3	Homo sapiens	29-38
18950289-9	2009	The combination of BMP-2 and TGF-beta3 in alginate culture is superior to the standard differentiation method using TGF-beta alone.	Alginates	42-50	transforming growth factor beta 3	Homo sapiens	29-37
19126428-2	2009	METHODS: Terbutaline sulfate and bovine serum albumin (BSA)-loaded alginate-poloxamer microparticles were prepared by a w/o-emulsion- and external gelation method.	Alginates	67-75	albumin	Homo sapiens	40-53
19117820-5	2009	Soluble factors such as the cytokine interleukin-2 were readily incorporated into self-gelling alginate matrices by simply mixing them with the formulation prior to gelation.	Alginates	95-103	interleukin 2	Mus musculus	37-50
19390433-4	2009	Encapsulation within alginate led to a six-fold enhancement in the generation and release of hIGF-1 to 22 ng of hIGF-1 per 10(6) cells per 24 hours.	Alginates	21-29	insulin like growth factor 1	Homo sapiens	93-99
19390433-4	2009	Encapsulation within alginate led to a six-fold enhancement in the generation and release of hIGF-1 to 22 ng of hIGF-1 per 10(6) cells per 24 hours.	Alginates	21-29	insulin like growth factor 1	Homo sapiens	112-118
19194788-1	2009	To evaluate the chaperone-like activity of alginate stabilization and refolding of alkaline phosphatase (ALP) was investigated in the presence of alginate through two different approaches, the soluble form and microcapsule assisted methods.	Alginates	43-51	alkaline phosphatase, placental	Homo sapiens	83-103
19194788-1	2009	To evaluate the chaperone-like activity of alginate stabilization and refolding of alkaline phosphatase (ALP) was investigated in the presence of alginate through two different approaches, the soluble form and microcapsule assisted methods.	Alginates	43-51	alkaline phosphatase, placental	Homo sapiens	105-108
19194788-1	2009	To evaluate the chaperone-like activity of alginate stabilization and refolding of alkaline phosphatase (ALP) was investigated in the presence of alginate through two different approaches, the soluble form and microcapsule assisted methods.	Alginates	146-154	alkaline phosphatase, placental	Homo sapiens	83-103
19194788-1	2009	To evaluate the chaperone-like activity of alginate stabilization and refolding of alkaline phosphatase (ALP) was investigated in the presence of alginate through two different approaches, the soluble form and microcapsule assisted methods.	Alginates	146-154	alkaline phosphatase, placental	Homo sapiens	105-108
19194788-3	2009	Lower refolding yields of alginate beads compared with its soluble form may be the result of lower refolding rate of ALP upon elution of the bound enzyme by dispersing the precipitate in NaCl which left the unfolded protein in an unsuitable environment, providing enough time for protein aggregation and leading finally to lower recovered activity compared with application of soluble form of alginate.	Alginates	26-34	alkaline phosphatase, placental	Homo sapiens	117-120
19194788-3	2009	Lower refolding yields of alginate beads compared with its soluble form may be the result of lower refolding rate of ALP upon elution of the bound enzyme by dispersing the precipitate in NaCl which left the unfolded protein in an unsuitable environment, providing enough time for protein aggregation and leading finally to lower recovered activity compared with application of soluble form of alginate.	Alginates	393-401	alkaline phosphatase, placental	Homo sapiens	117-120
18853429-3	2009	The animals were divided into four groups based on the implant material: autologous iliac graft, Alginate-MSCs composite, Alginate-BMP-2-MSCs composite, and Alginate-BMP-2 composite.	Alginates	122-130	bone morphogenetic protein 2	Oryctolagus cuniculus	131-136
19548568-8	2009	CONCLUSION: No matter in vivo or in vitro, alginate both can affect the Th1/Th2 cytokines of mice spleen lymphocytes.	Alginates	43-51	negative elongation factor complex member C/D, Th1l	Mus musculus	72-75
19548568-8	2009	CONCLUSION: No matter in vivo or in vitro, alginate both can affect the Th1/Th2 cytokines of mice spleen lymphocytes.	Alginates	43-51	heart and neural crest derivatives expressed 2	Mus musculus	76-79
19128965-4	2009	Zeta position and BET surface area were used to explain the adsorption behavior of SA immobilized beads.	Alginates	83-85	delta/notch like EGF repeat containing	Homo sapiens	18-21
19135246-3	2009	By comparing Pep-1- and PolyFect-mediated QD internalizations, the connexin 43 (Cx43)-mediated gap junction intercellular communication (GJIC) of human adipose-derived adult stem cells was investigated in monolayer and in three-dimensional (3D) culture (alginate hollow spheres).	Alginates	254-262	gap junction protein alpha 1	Homo sapiens	67-78
19135246-3	2009	By comparing Pep-1- and PolyFect-mediated QD internalizations, the connexin 43 (Cx43)-mediated gap junction intercellular communication (GJIC) of human adipose-derived adult stem cells was investigated in monolayer and in three-dimensional (3D) culture (alginate hollow spheres).	Alginates	254-262	gap junction protein alpha 1	Homo sapiens	80-84
19428712-0	2009	Molecular characterization of Alg8, a putative glycosyltransferase, involved in alginate polymerisation.	Alginates	80-88	ALG8 alpha-1,3-glucosyltransferase	Homo sapiens	30-34
19428712-7	2009	The role of these amino acid residues with respect to the catalysed alginate polymerisation reaction was discussed with the aid of the recently developed structural model of Alg8.	Alginates	68-76	ALG8 alpha-1,3-glucosyltransferase	Homo sapiens	174-178
19548568-0	2009	[Effects of alginate on Th1/Th2 cytokines in vivo and in vitro of mice spleen lymphocytes].	Alginates	12-20	negative elongation factor complex member C/D, Th1l	Mus musculus	24-27
19548568-0	2009	[Effects of alginate on Th1/Th2 cytokines in vivo and in vitro of mice spleen lymphocytes].	Alginates	12-20	heart and neural crest derivatives expressed 2	Mus musculus	28-31
19548568-1	2009	OBJECTIVE: To study effects of alginate on Th1/Th2 cytokines in vivo and in vitro of mice spleen lymphocytes.	Alginates	31-39	negative elongation factor complex member C/D, Th1l	Mus musculus	43-46
19548568-1	2009	OBJECTIVE: To study effects of alginate on Th1/Th2 cytokines in vivo and in vitro of mice spleen lymphocytes.	Alginates	31-39	heart and neural crest derivatives expressed 2	Mus musculus	47-50
19548568-6	2009	RESULTS: In vivo test: Compared with the negative control, the IFN-gamma of 0.5 g/kg bw and 1.5 g/kg bw alginate groups showed marked elevation (P &lt; 0.01), while IL-2 and IL-4 were both decreased (P &lt; 0.05, P &lt; 0.01).	Alginates	104-112	interferon gamma	Mus musculus	63-72
19548568-6	2009	RESULTS: In vivo test: Compared with the negative control, the IFN-gamma of 0.5 g/kg bw and 1.5 g/kg bw alginate groups showed marked elevation (P &lt; 0.01), while IL-2 and IL-4 were both decreased (P &lt; 0.05, P &lt; 0.01).	Alginates	104-112	interleukin 2	Mus musculus	165-169
19548568-6	2009	RESULTS: In vivo test: Compared with the negative control, the IFN-gamma of 0.5 g/kg bw and 1.5 g/kg bw alginate groups showed marked elevation (P &lt; 0.01), while IL-2 and IL-4 were both decreased (P &lt; 0.05, P &lt; 0.01).	Alginates	104-112	interleukin 4	Mus musculus	174-178
19548568-7	2009	In vitro test: Compared with control group, TNF, IL-2 and IL-4 of 25 mg/ml and 50 mg/ml alginate groups (P &lt; 0.05, P &lt; 0.01) and IL-5 of 50 mg/ml alginate group (P &lt; 0.01) were all increased.	Alginates	88-96	interleukin 4	Mus musculus	58-62
19150078-1	2009	The intermolecular interactions between the model protein, bovine serum albumin (BSA) and a biocompatible polysaccharide, sodium alginate, have been investigated.	Alginates	122-137	albumin	Homo sapiens	66-79
19067172-0	2009	Magnetic alginate microspheres: system for the position controlled delivery of nerve growth factor.	Alginates	9-17	nerve growth factor	Rattus norvegicus	79-98
19067172-2	2009	In this paper a system comprised of alginate microparticles with a core of magnetite and carrying nerve growth factor (NGF) is described.	Alginates	36-44	nerve growth factor	Rattus norvegicus	98-117
19067172-2	2009	In this paper a system comprised of alginate microparticles with a core of magnetite and carrying nerve growth factor (NGF) is described.	Alginates	36-44	nerve growth factor	Rattus norvegicus	119-122
19067172-4	2009	Experiments carried out on PC12 cells with magnetic alginate microspheres loaded with NGF have confirmed the induction of cell differentiation which is strongly dependent on the distance from the microsphere cluster.	Alginates	52-60	nerve growth factor	Rattus norvegicus	86-89
19332805-0	2009	Lipotoxin F of Pseudomonas aeruginosa is an AlgU-dependent and alginate-independent outer membrane protein involved in resistance to oxidative stress and adhesion to A549 human lung epithelia.	Alginates	63-71	outer membrane porin F	Pseudomonas aeruginosa PAO1	0-11
18853429-3	2009	The animals were divided into four groups based on the implant material: autologous iliac graft, Alginate-MSCs composite, Alginate-BMP-2-MSCs composite, and Alginate-BMP-2 composite.	Alginates	122-130	bone morphogenetic protein 2	Oryctolagus cuniculus	131-136
18853429-8	2009	The failure torque did not differ significantly between the autograft and Alginate-BMP-2-MSCs groups; both groups were significantly higher than the Alginate-MSCs group.	Alginates	74-82	bone morphogenetic protein 2	Oryctolagus cuniculus	83-88
18835344-0	2009	Serum albumin-alginate coated microspheres: role of the inner gel in binding and release of the KRFK peptide.	Alginates	14-22	albumin	Homo sapiens	0-13
19027807-0	2009	Controlled delivery of VEGF via modulation of alginate microparticle ionic crosslinking.	Alginates	46-54	vascular endothelial growth factor A	Homo sapiens	23-27
19027807-2	2009	Alginate has emerged as a popular material for VEGF delivery; however most alginate-based systems offer limited means to control the rate of VEGF release beyond reducing the VEGF:alginate ratio to suboptimal efficiency.	Alginates	0-8	vascular endothelial growth factor A	Homo sapiens	47-51
19027807-3	2009	This study describes methods to control the release of VEGF from small (&lt;10 microm mean diameter) alginate microparticles via the use of different ionic crosslinkers.	Alginates	101-109	vascular endothelial growth factor A	Homo sapiens	55-59
19027807-6	2009	These results demonstrate that ionic modulation of alginate crosslinking is a viable strategy for controlling release of VEGF while retaining the high protein:polymer ratio that makes alginate an attractive carrier for delivery of protein therapeutics.	Alginates	51-59	vascular endothelial growth factor A	Homo sapiens	121-125
19320163-3	2009	We measured the Donnan potential and partitioning of Cd2+ in alginate gel as a function of ionic strength in the range 1-100 mM.	Alginates	61-69	CD2 molecule	Homo sapiens	53-56
19059641-6	2009	We demonstrated that inclusion of alginate gel in both designs is efficient in preventing cell leakage to the surrounding yet permitting the GDNF secretion, although the cellular growth rate is reduced in an alginate concentration dependent manner.	Alginates	34-42	glial cell derived neurotrophic factor	Homo sapiens	141-145
19059641-8	2009	The collagen-alginate composite gel maintains a more or less constant GDNF secretion over time while the collagen microspheres embedded in alginate gel continue to increase the secretion level of GDNF over time.	Alginates	139-147	glial cell derived neurotrophic factor	Homo sapiens	196-200
19160351-7	2009	In alginate cultures, inhibition of collagen crosslinking with BAPN, in combination with promotion of matrix synthesis using IGF1, was most beneficial for matrix deposition.	Alginates	3-11	insulin like growth factor 1	Bos taurus	125-129
18950709-1	2009	The aim of this work was to develop a novel composite alginate/poly(lactic-co-glycolic) acid microparticulate system for protein stabilization and delivery using bovine insulin as model drug.	Alginates	54-62	insulin	Bos taurus	169-176
18950709-8	2009	Moreover, no significant peptide adsorption on blank PLGA or blank composite microparticles was observed while, a strong interaction between alginate particles and bovine insulin was detected.	Alginates	141-149	insulin	Bos taurus	171-178
19889209-6	2009	The suppression of the ADAMTS5 gene by siRNA transfection was assessed by using real-time polymerase chain reaction (PCR), both in monolayer and alginate bead cultures with or without interleukin-1beta (IL-1beta) stimulation.	Alginates	145-153	LOW QUALITY PROTEIN: A disintegrin and metalloproteinase with thrombospondin motifs 5	Oryctolagus cuniculus	23-30
19435506-1	2009	INTRODUCTION: The aim of this study was to compare the effects of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1beta) on protease and catabolic cytokine and receptor gene expression in normal and degenerate human nucleus pulposus cells in alginate culture.	Alginates	262-270	interleukin 1 beta	Homo sapiens	111-129
19435506-1	2009	INTRODUCTION: The aim of this study was to compare the effects of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1beta) on protease and catabolic cytokine and receptor gene expression in normal and degenerate human nucleus pulposus cells in alginate culture.	Alginates	262-270	interleukin 1 beta	Homo sapiens	131-139
19889209-11	2009	ADAMTS5 gene suppression was 70% compared with the control oligonucleotide in both monolayer and alginate bead culture with or without stimulation with IL-1beta.	Alginates	97-105	LOW QUALITY PROTEIN: A disintegrin and metalloproteinase with thrombospondin motifs 5	Oryctolagus cuniculus	0-7
19012272-10	2009	We found an increase of ALP as well as BSPII expression for osteogenic-induced hBMSCs on alginate-gelatin-HA scaffolds.	Alginates	89-97	alkaline phosphatase, placental	Homo sapiens	24-27
19012272-10	2009	We found an increase of ALP as well as BSPII expression for osteogenic-induced hBMSCs on alginate-gelatin-HA scaffolds.	Alginates	89-97	integrin binding sialoprotein	Homo sapiens	39-44
18829100-0	2008	Accelerated wound healing by smad3 antisense oligonucleotides-impregnated chitosan/alginate polyelectrolyte complex.	Alginates	83-91	SMAD family member 3	Mus musculus	29-34
20099737-4	2009	In this study, water-soluble sodium alginates contained in active dressings Medisorb A were identified using electrophoresis on cellulose acetate CAE.	Alginates	29-45	gap junction protein alpha 8	Homo sapiens	146-149
18829100-2	2008	Smad3 antisense oligonucleotides (ASOs) impregnated polyelectrolyte complex (PEC) containing chitosan and sodium alginate was prepared for accelerated wound healing.	Alginates	106-121	SMAD family member 3	Mus musculus	0-5
18829100-8	2008	These results demonstrate that the smad3 ASOs-PEC composed of chitosan and sodium alginate could be applied for accelerated wound healing.	Alginates	75-90	SMAD family member 3	Mus musculus	35-40
18491951-0	2008	Effects of exogenous IGF-1 delivery on the early expression of IGF-1 signaling molecules by alginate embedded chondrocytes.	Alginates	92-100	insulin like growth factor 1	Homo sapiens	21-26
18554936-8	2008	RESULTS: Chondrogenic differentiation of both CD56+ and CD56- muscle-derived cells was improved in alginate scaffold, even without growth factor, as suggested by increased chondrogenesis markers expression during the culture.	Alginates	99-107	neural cell adhesion molecule 1	Homo sapiens	46-50
18554936-8	2008	RESULTS: Chondrogenic differentiation of both CD56+ and CD56- muscle-derived cells was improved in alginate scaffold, even without growth factor, as suggested by increased chondrogenesis markers expression during the culture.	Alginates	99-107	neural cell adhesion molecule 1	Homo sapiens	56-60
18554936-10	2008	Of importance, the combination of alginate and TGFbeta1 treatment resulted in a further down-regulation of collagen type I and type X, as well as Cbfa1 both expression and binding activity.	Alginates	34-42	RUNX family transcription factor 2	Homo sapiens	146-151
18554936-11	2008	CONCLUSIONS: Thus, alginate scaffold and chondrogenic medium are sufficient to lead both populations CD56+ and CD56- towards chondrogenic differentiation.	Alginates	19-27	neural cell adhesion molecule 1	Homo sapiens	101-105
18554936-11	2008	CONCLUSIONS: Thus, alginate scaffold and chondrogenic medium are sufficient to lead both populations CD56+ and CD56- towards chondrogenic differentiation.	Alginates	19-27	neural cell adhesion molecule 1	Homo sapiens	111-115
18644444-0	2008	Preparation and evaluation of mucinated sodium alginate microparticles for oral delivery of insulin.	Alginates	40-55	insulin	Oryctolagus cuniculus	92-99
18644444-2	2008	In this study, insulin-loaded microparticles for oral delivery were prepared with mucin and sodium alginate combined at different ratios using a novel method based on polymer coacervation and diffusion filling.	Alginates	92-107	insulin	Oryctolagus cuniculus	15-22
18644444-7	2008	The insulin content of the microparticles increased with increase in their sodium alginate content.	Alginates	75-90	insulin	Oryctolagus cuniculus	4-11
18644444-8	2008	The various insulin-loaded microparticles prepared with the mucinated sodium alginate when encapsulated exhibited lag time before insulin release.	Alginates	70-85	insulin	Oryctolagus cuniculus	12-19
18644444-8	2008	The various insulin-loaded microparticles prepared with the mucinated sodium alginate when encapsulated exhibited lag time before insulin release.	Alginates	70-85	insulin	Oryctolagus cuniculus	130-137
18644444-9	2008	The time taken to reach maximum insulin release from the various formulations varied with the mucin-sodium alginate ratio mix.	Alginates	100-115	insulin	Oryctolagus cuniculus	32-39
18644444-10	2008	The mean dissolution time of insulin from the microparticles prepared with sodium alginate, mucin, sodium alginate: mucin ratios of 1:1, 3:1 and 1:3 was 11.21+/-0.75, 3.3+/-0.42, 6.69+/-023, 8.52+/-0.95 and 3.48+/-0.65 (min.	Alginates	75-90	insulin	Oryctolagus cuniculus	29-36
18644444-10	2008	The mean dissolution time of insulin from the microparticles prepared with sodium alginate, mucin, sodium alginate: mucin ratios of 1:1, 3:1 and 1:3 was 11.21+/-0.75, 3.3+/-0.42, 6.69+/-023, 8.52+/-0.95 and 3.48+/-0.65 (min.	Alginates	99-114	insulin	Oryctolagus cuniculus	29-36
18644444-13	2008	The blood glucose reduction effect produced by the orally administered insulin-loaded microparticles prepared with three parts of sodium alginate and one part of mucin after 5h was, however, equal to that produced by the subcutaneously administered insulin solution, an indication that it is an effective alternative for the delivery of insulin.	Alginates	130-145	insulin	Oryctolagus cuniculus	71-78
19238724-0	2008	Alginate-matrigel microencapsulated schwann cells for inducible secretion of glial cell line derived neurotrophic factor.	Alginates	0-8	glial cell derived neurotrophic factor	Homo sapiens	77-120
19238724-2	2008	This delivery strategy was demonstrated via inducible Gdnf from microencapsulated cells in barium alginate.	Alginates	91-106	glial cell derived neurotrophic factor	Homo sapiens	54-58
19238724-6	2008	Encapsulation of RT4-Gdnf in 1% alginate was then performed.	Alginates	32-40	glial cell derived neurotrophic factor	Homo sapiens	21-25
19238724-9	2008	Mixture of basement membrane extract Matrigel to alginate promoted increased proliferation, cell spreading and Gdnf release.	Alginates	49-57	glial cell derived neurotrophic factor	Homo sapiens	111-115
18656951-3	2008	To demonstrate this assay platform, we examined the accumulation of the alpha subunit of the hypoxia-inducible factor (HIF-1alpha) after chemical stimulation of human pancreatic tumor cells encapsulated in 3D alginate spots in volumes as low as 60 nL.	Alginates	209-217	hypoxia inducible factor 1 subunit alpha	Homo sapiens	119-129
18689918-8	2008	The differences in the mechanical properties and cell growth profiles between the scaffolds containing ASF and NASF can be explained by the formation and non-formation of electrostatic bonds between the fibres and alginate, respectively.	Alginates	214-222	arylsulfatase F	Homo sapiens	103-106
18465312-3	2008	A thorough investigation has been conducted to optimize and characterize alginate biotinylation via carbodiimide chemistry by a 4"-hydroxyazobenzene-2-carboxylic acid (HABA) based assay and by ATR-FTIR, H-NMR and XPS.	Alginates	73-81	ATR serine/threonine kinase	Homo sapiens	193-196
18616316-0	2008	pH-dependent behaviors of electroactive myoglobin loaded into layer-by-layer films assembled with alginate and hydroxyethyl cellulose ethoxylate.	Alginates	98-106	myoglobin	Homo sapiens	40-49
18462788-7	2008	Mixed hydrogels of alginate/alginate-sulfate sustained the release of basic FGF, with the release rate being dependent on the percentage of bFGF bound to the hydrogels.	Alginates	19-27	fibroblast growth factor 2	Homo sapiens	76-79
18462788-7	2008	Mixed hydrogels of alginate/alginate-sulfate sustained the release of basic FGF, with the release rate being dependent on the percentage of bFGF bound to the hydrogels.	Alginates	19-27	fibroblast growth factor 2	Homo sapiens	140-144
18462788-8	2008	In vivo, the delivery of bFGF bound to alginate/alginate-sulfate scaffolds induced the formation of twice the number of blood vessels compared to when bFGF was delivered adsorbed to the matrix and 51% of the vessels were matured, as judged by pericyte coverage of the vessels.	Alginates	39-47	fibroblast growth factor 2	Homo sapiens	25-29
18462788-8	2008	In vivo, the delivery of bFGF bound to alginate/alginate-sulfate scaffolds induced the formation of twice the number of blood vessels compared to when bFGF was delivered adsorbed to the matrix and 51% of the vessels were matured, as judged by pericyte coverage of the vessels.	Alginates	39-47	fibroblast growth factor 2	Homo sapiens	151-155
18628692-2	2008	OBJECTIVE: To evaluate the time-course effect of simvastatin on the gene expression of bone morphogenetic protein-2 (BMP-2), aggrecan, and collagen type II in rat IVD cells cultured in alginate bead.	Alginates	185-193	bone morphogenetic protein 2	Rattus norvegicus	87-115
18439774-0	2008	Concanavalin A layered calcium alginate-starch beads immobilized beta galactosidase as a therapeutic agent for lactose intolerant patients.	Alginates	23-39	galactosidase beta 1	Homo sapiens	65-83
18439774-1	2008	A novel therapeutic agent in the form of beta galactosidase immobilized on the surface of concanavalin A layered calcium alginate-starch beads has been developed.	Alginates	113-129	galactosidase beta 1	Homo sapiens	41-59
18947384-4	2008	The anti-angiogenesis of sFlt-1 in BMSCs was determined using endothelial cells proliferation inhibition assay and alginate encapsulation assay.	Alginates	115-123	FMS-like tyrosine kinase 1	Mus musculus	25-31
18080296-0	2008	Tissue engineered cartilage from hTGF beta2 transduced human adipose derived stem cells seeded in PLGA/alginate compound in vitro and in vivo.	Alginates	103-111	transforming growth factor beta 2	Homo sapiens	33-43
18702546-0	2008	Mechanical properties of C-5 epimerized alginates.	Alginates	40-49	complement C5	Homo sapiens	25-28
18455230-4	2008	Cylinders of brushite cement, hydroxyapatite cement and sodium alginate were loaded with RANKL either by incorporation into the cement or by coating the material with soluble RANKL.	Alginates	56-71	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	89-94
18450813-4	2008	Here, we report the development of a novel alginate-based delivery system for vascular endothelial growth factor-A(165) (VEGF) that exhibits superior loading efficiency and physical properties to previous systems in vitro.	Alginates	43-51	vascular endothelial growth factor A	Homo sapiens	78-119
18450813-4	2008	Here, we report the development of a novel alginate-based delivery system for vascular endothelial growth factor-A(165) (VEGF) that exhibits superior loading efficiency and physical properties to previous systems in vitro.	Alginates	43-51	vascular endothelial growth factor A	Homo sapiens	121-125
18450813-5	2008	In vivo, VEGF released from alginate microparticles within protein gels was biologically active and, when combined with EC transplantation, led to increased survival of transplanted cells at 28 days.	Alginates	28-36	vascular endothelial growth factor A	Homo sapiens	9-13
18491951-0	2008	Effects of exogenous IGF-1 delivery on the early expression of IGF-1 signaling molecules by alginate embedded chondrocytes.	Alginates	92-100	insulin like growth factor 1	Homo sapiens	63-68
18491951-12	2008	Overall, results indicate that exogenous IGF-1 delivery does affect signaling molecule expression by chondrocytes embedded in alginate hydrogels, particularly downregulating the delivered signal while upregulating its receptor.	Alginates	126-134	insulin like growth factor 1	Homo sapiens	41-46
17960567-10	2008	Cells in alginate treated with BMP-2 resulted in increased synthesis of proteoglycan which was released into the conditioned media on IL-1 stimulation.	Alginates	9-17	bone morphogenetic protein 2	Mus musculus	31-36
19230128-9	2008	In alginate, primary and expanded cells displayed an unexpected decrease in collagen cross-linking with TGFbeta2.	Alginates	3-11	transforming growth factor beta 2	Homo sapiens	104-112
17945515-13	2008	CONCLUSION: Our work shows chondrocytes in osteoarthritic cartilage exhibit DNA damage, and that IL-1 induces DNA damage and reactive oxygen and nitrogen species in non-OA chondrocytes in alginate.	Alginates	188-196	interleukin 1 alpha	Homo sapiens	97-101
18432591-0	2008	Three-dimensional growth of human hepatoma C3A cells within alginate beads for fluidized bioartificial liver.	Alginates	60-68	complement C3	Homo sapiens	43-46
18432591-4	2008	The hepatic cell line C3A was encapsulated in alginate beads.	Alginates	46-54	complement C3	Homo sapiens	22-25
18432591-11	2008	Prolonged static cultivation of C3A cells within the alginate beads in both types of alginates caused significant increases in albumin production in the fluidized bioreactor.	Alginates	53-61	complement C3	Homo sapiens	32-35
18432591-11	2008	Prolonged static cultivation of C3A cells within the alginate beads in both types of alginates caused significant increases in albumin production in the fluidized bioreactor.	Alginates	85-94	complement C3	Homo sapiens	32-35
18432591-12	2008	CONCLUSIONS: Cultivation of the hepatic C3A cells within the alginate microbeads significantly improved bioreactor effectiveness in albumin production.	Alginates	61-69	complement C3	Homo sapiens	40-43
17854068-2	2008	Alginate microspheres of IFN-alpha were first prepared by an emulsion method and further incubated in chitosan to form IFN-ACM.	Alginates	0-8	interferon alpha	Mus musculus	25-34
17960567-10	2008	Cells in alginate treated with BMP-2 resulted in increased synthesis of proteoglycan which was released into the conditioned media on IL-1 stimulation.	Alginates	9-17	interleukin 1 complex	Mus musculus	134-138
18435858-8	2008	Stimulation of bovine nucleus pulposus cells cultured in alginate beads for 21 days with FGF2 resulted in a dose-dependent decrease in PG accumulation, due at least in part to the inhibition of PG synthesis.	Alginates	57-65	fibroblast growth factor 2	Bos taurus	89-93
17978832-7	2008	There was complete repair of cranial defects in experimental group using the alginate gel loading BMP-2 transfected ASC, but only partial repair in negative controls and in the blank control.	Alginates	77-85	bone morphogenetic protein 2	Rattus norvegicus	98-103
17978832-7	2008	There was complete repair of cranial defects in experimental group using the alginate gel loading BMP-2 transfected ASC, but only partial repair in negative controls and in the blank control.	Alginates	77-85	PYD and CARD domain containing	Rattus norvegicus	116-119
17978832-0	2008	Bone regeneration by BMP-2 enhanced adipose stem cells loading on alginate gel.	Alginates	66-74	bone morphogenetic protein 2	Rattus norvegicus	21-26
19163802-6	2008	Here, we present reversible immobilization of human fetal lung fibroblasts (HFL1) and human hepatocellular liver carcinoma cell (Hep G2) inside microfluidic channels and demonstrate the possibility of co-culturing these two cell types within different alginate gel layers.	Alginates	252-260	complement factor H related 1	Homo sapiens	76-80
18484491-0	2008	Alginate inserts loaded with epidermal growth factor for the treatment of keratoconjunctivitis sicca.	Alginates	0-8	epidermal growth factor	Homo sapiens	29-52
17897711-2	2008	We have adopted a non-viral gene delivery and tissue engineering strategy, in which Sox-9 transfected human mesenchymal progenitors have been encapsulated within alginate/chitosan polysaccharide capsules to promote chondrogenesis.	Alginates	162-170	SRY-box transcription factor 9	Homo sapiens	84-89
17981963-0	2008	The NtrC family regulator AlgB, which controls alginate biosynthesis in mucoid Pseudomonas aeruginosa, binds directly to the algD promoter.	Alginates	47-55	two-component response regulator AlgB	Pseudomonas aeruginosa PAO1	26-30
17981963-1	2008	Alginate production in mucoid (MucA-defective) Pseudomonas aeruginosa is dependent upon several transcriptional regulators, including AlgB, a two-component response regulator belonging to the NtrC family.	Alginates	0-8	two-component response regulator AlgB	Pseudomonas aeruginosa PAO1	134-138
17981963-6	2008	This suggested that AlgB promotes alginate production by directly binding to the algD promoter (PalgD).	Alginates	34-42	two-component response regulator AlgB	Pseudomonas aeruginosa PAO1	20-24
18814578-0	2008	Comparative equilibrium studies of sorption of Pb(II) ions by sodium and calcium alginate.	Alginates	73-89	submaxillary gland androgen regulated protein 3B	Homo sapiens	47-53
18814578-1	2008	The absorption of Pb(II) ions from aqueous solution by different alginate compounds was studied in a batch sorption system.	Alginates	65-73	submaxillary gland androgen regulated protein 3B	Homo sapiens	18-24
18814578-4	2008	The binding capacities and rates of Pb(II) ions by alginate compounds were evaluated.	Alginates	51-59	submaxillary gland androgen regulated protein 3B	Homo sapiens	36-42
18814578-8	2008	The largest amount of Pb(II) ions were bound by sodium alginate although the difference between two compounds was slight.	Alginates	48-63	submaxillary gland androgen regulated protein 3B	Homo sapiens	22-28
18814578-9	2008	Therefore, alginate substances may be considered as an alternative for sorption and removal of Pb(II) ions from wastewaters.	Alginates	11-19	submaxillary gland androgen regulated protein 3B	Homo sapiens	95-101
17886325-3	2007	In the coating series with trypsin/PSS, the amount of immobilized enzyme was larger than that with trypsin/alginate.	Alginates	107-115	PSS	Homo sapiens	35-38
19662133-5	2007	The addition of the growth factors IGF-I (100 ng/mL) and TGF-beta1 (10 ng/mL) during the alginate culture and the absence of any growth factors during the high-density cell culture led to significantly higher GAG to DNA ratios and Young"s Moduli of the constructs compared to other combinations.	Alginates	89-97	insulin like growth factor 1	Homo sapiens	35-40
19662133-5	2007	The addition of the growth factors IGF-I (100 ng/mL) and TGF-beta1 (10 ng/mL) during the alginate culture and the absence of any growth factors during the high-density cell culture led to significantly higher GAG to DNA ratios and Young"s Moduli of the constructs compared to other combinations.	Alginates	89-97	transforming growth factor beta 1	Homo sapiens	57-66
17941669-0	2007	In vitro characterization and in vivo functionality of erythropoietin-secreting cells immobilized in alginate-poly-L-lysine-alginate microcapsules.	Alginates	101-109	erythropoietin	Homo sapiens	55-69
18232481-2	2007	The BSA-alginate sodium microsphere was fabricated with W/O emulsification and ion cross-linking method using alginate sodium.	Alginates	8-23	albumin	Homo sapiens	4-7
18232481-2	2007	The BSA-alginate sodium microsphere was fabricated with W/O emulsification and ion cross-linking method using alginate sodium.	Alginates	110-125	albumin	Homo sapiens	4-7
18232481-3	2007	The appearance, microsphere diameter and envelopment rate were detected, and the release characteristics of the BSA-alginate sodium microsphere in vitro was investigated.	Alginates	116-131	albumin	Homo sapiens	112-115
18232481-6	2007	Smooth controlled release in BSA-alginate sodium microsphere was shown to last more than 2 weeks.	Alginates	33-48	albumin	Homo sapiens	29-32
18277681-6	2007	RESULTS: DNA quantitation in the variant culture systems indicated that in monolayers the NP cells at Passage 3 transfected with Ad/hTGF-beta1 had a much higher cell viability and more DNA synthesis (P &lt; 0.05); however, in the alginate 3-D culture system, the NP cells transfected with Ad/hTGF-bea1 did not have any significant difference from the controls (P &gt; 0.05).	Alginates	230-238	transforming growth factor beta 1	Homo sapiens	132-142
18277681-11	2007	The NP cells transfected with Ad/ hTGF-beta1 cultured in the 3-D alginate bead systems can show a nearly native phenotype.	Alginates	65-73	transforming growth factor beta 1	Homo sapiens	34-44
17767917-1	2007	We investigated the encapsulation of BMP-2 gene-modified mesenchymal stem cells (MSCs) in alginate-poly-L-lysine (APA) microcapsules for the persistent delivery of bone morphogenic protein-2 (BMP-2) to induce bone formation.	Alginates	90-98	bone morphogenetic protein 2	Homo sapiens	37-42
17767917-1	2007	We investigated the encapsulation of BMP-2 gene-modified mesenchymal stem cells (MSCs) in alginate-poly-L-lysine (APA) microcapsules for the persistent delivery of bone morphogenic protein-2 (BMP-2) to induce bone formation.	Alginates	90-98	bone morphogenetic protein 2	Homo sapiens	164-190
17941669-2	2007	In the present paper, alginate-poly-l-lysine-alginate (APA) microcapsules containing erythropoietin (Epo)-secreting C2C12 myoblasts have been elaborated, characterized, and tested both in vitro and in vivo.	Alginates	22-30	erythropoietin	Homo sapiens	85-99
17941669-2	2007	In the present paper, alginate-poly-l-lysine-alginate (APA) microcapsules containing erythropoietin (Epo)-secreting C2C12 myoblasts have been elaborated, characterized, and tested both in vitro and in vivo.	Alginates	22-30	erythropoietin	Homo sapiens	101-104
17766417-1	2007	AlgR controls numerous virulence factors in Pseudomonas aeruginosa, including alginate, hydrogen cyanide production, and type IV pilus-mediated twitching motility.	Alginates	78-86	alginate biosynthesis regulatory protein AlgR	Pseudomonas aeruginosa PAO1	0-4
17481597-7	2007	RESULTS: Alginate gels were capable of delivering VEGF-A(165) and PDGF-BB in a sustainable manner, and PDGF-BB was released more slowly than VEGF-A(165).	Alginates	9-17	vascular endothelial growth factor A	Rattus norvegicus	50-56
18257237-1	2007	With sodium alginate as a carrier and glutaraldehyde as the crosslinking agent, an improved immobilization method of beta-glucosidase for production of soybean genistein was developed.	Alginates	5-20	LOC547491	Glycine max	117-133
18257237-2	2007	As compared with entrapment or entrapment-crosslinkage, crosslinkage-entrapment that beta-glucosidase was treated with glutaraldehyde and then entrapped in sodium alginate remained high loading efficiency and activity recovery, Effects of bead sizes, concentrations of alginate and glutaraldehyde as well, on the loading efficiency and activity recovery were assessed.	Alginates	156-171	LOC547491	Glycine max	85-101
18257237-2	2007	As compared with entrapment or entrapment-crosslinkage, crosslinkage-entrapment that beta-glucosidase was treated with glutaraldehyde and then entrapped in sodium alginate remained high loading efficiency and activity recovery, Effects of bead sizes, concentrations of alginate and glutaraldehyde as well, on the loading efficiency and activity recovery were assessed.	Alginates	163-171	LOC547491	Glycine max	85-101
17583454-2	2007	In the present study, we implanted alginate-poly-L-lysine-alginate microcapsules containing immobilized Fischer rat 3T3 fibroblasts transfected to produce GDNF in vitro into the striatum of 6-hydroxydopamine (6-OHDA) lesioned rats.	Alginates	35-43	glial cell derived neurotrophic factor	Rattus norvegicus	155-159
17532040-5	2007	Cells within RGD-modified alginate microspheres were able to establish more interactions with the synthetic extracellular matrix as visualized by confocal laser scanning microscope and transmission electron microscopy imaging, and presented a much higher level of differentiation (more intense ALP and mineralization stainings and higher levels of osteocalcin secretion) when compared to cells immobilized within unmodified alginate microspheres.	Alginates	26-34	alkaline phosphatase, placental	Homo sapiens	294-297
17532040-5	2007	Cells within RGD-modified alginate microspheres were able to establish more interactions with the synthetic extracellular matrix as visualized by confocal laser scanning microscope and transmission electron microscopy imaging, and presented a much higher level of differentiation (more intense ALP and mineralization stainings and higher levels of osteocalcin secretion) when compared to cells immobilized within unmodified alginate microspheres.	Alginates	26-34	bone gamma-carboxyglutamate protein	Homo sapiens	348-359
17398046-2	2007	GOX was encapsulated in alginate/chitosan microspheres (ACMS) using an emulsification-internal gelation, followed by GOX adsorption and polyelectrolyte coating method.	Alginates	24-32	hydroxyacid oxidase 1	Homo sapiens	0-3
17127052-4	2007	Indeed, in the presence of exogenous alpha-amylase, 9% (w/v) soluble starch was converted to 43.1g ethanol/l in 65 h with a productivity of 0.65 g/l h. Thus, bio-ethanol production using free and calcium alginate-immobilized C. tropicalis does not require the saccharification step.	Alginates	196-212	alpha-amylase	Zea mays	37-50
17705442-3	2007	The purpose of this study is to evaluate the drug delivery potential of AOT-alginate nanoparticles in drug-resistant cells overexpressing the drug efflux transporter, P-glycoprotein (P-gp).	Alginates	76-84	ATP binding cassette subfamily B member 1	Homo sapiens	167-181
17705442-3	2007	The purpose of this study is to evaluate the drug delivery potential of AOT-alginate nanoparticles in drug-resistant cells overexpressing the drug efflux transporter, P-glycoprotein (P-gp).	Alginates	76-84	ATP binding cassette subfamily B member 1	Homo sapiens	183-187
17685304-0	2007	Insulin-loaded nanoparticles are prepared by alginate ionotropic pre-gelation followed by chitosan polyelectrolyte complexation.	Alginates	45-53	insulin	Homo sapiens	0-7
17685304-4	2007	The association efficiency of insulin into alginate nanoparticles, as well as loading capacity were mainly influenced by the alginate:chitosan mass ratio.	Alginates	43-51	insulin	Homo sapiens	30-37
17685304-4	2007	The association efficiency of insulin into alginate nanoparticles, as well as loading capacity were mainly influenced by the alginate:chitosan mass ratio.	Alginates	125-133	insulin	Homo sapiens	30-37
17350677-0	2007	Alginate as an antiglycating agent for human serum albumin.	Alginates	0-8	albumin	Homo sapiens	45-58
17350677-3	2007	In this study, the interaction of human serum albumin (HSA) with fructose, in the absence and presence of alginate, was studied by circular dichroism, absorbance and fluorescence techniques.	Alginates	106-114	albumin	Homo sapiens	40-53
17368052-10	2007	Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture, and deliver an FGF-dependent activation of ERK when loaded.	Alginates	29-37	fibroblast growth factor 2	Homo sapiens	88-93
17368052-10	2007	Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture, and deliver an FGF-dependent activation of ERK when loaded.	Alginates	29-37	fibroblast growth factor 2	Homo sapiens	88-91
17368052-10	2007	Chondrocytes encapsulated in alginate were able to accumulate pericellular perlecan and FGF-2 in culture, and deliver an FGF-dependent activation of ERK when loaded.	Alginates	29-37	mitogen-activated protein kinase 1	Homo sapiens	149-152
17630143-4	2007	STUDY DESIGN: A short-term in vitro study using normal and interleukin (IL)-1alpha stimulated porcine disc cells cultured in alginate gel to evaluate the biochemical effects of electrosurgical ablation.	Alginates	125-133	interleukin 1 alpha	Homo sapiens	59-82
17336950-3	2007	After ip injection of 700 mg/kg of oligomers, the serum level of G-CSF increased promptly and reached the maximum level after 2 h and this high level was sustained until 6 h, and then gradually decreased, whereas injection of 700 mg/kg of alginate polymer had no effect.	Alginates	239-247	peripheral blood stem cell response to granulocyte colony stimulating factor 1	Mus musculus	65-70
17507830-1	2007	BACKGROUND: The objective of this study was to use a chitosan-alginate gel to implant bone marrow-derived mesenchymal stem cells subcutaneously in a minimally invasive manner and promote bone formation by the simultaneously transferred osteogenic protein (OP)-1 (bone morphogenic protein-7) gene.	Alginates	62-70	bone morphogenetic protein 7	Homo sapiens	236-261
17317051-3	2007	In this work, the expression profile of CD69 in mice splenocytes was evaluated following exposure to the biopolymers, chitosan or alginate and the immunostimulatory factors, CpG ODN 1826 or concanavalin A.	Alginates	130-138	CD69 antigen	Mus musculus	40-44
17336950-4	2007	The effect of alginate oligomer mixture was dose-dependent, and 70 mg/kg was sufficient to attain the maximum serum level of G-CSF.	Alginates	14-22	peripheral blood stem cell response to granulocyte colony stimulating factor 1	Mus musculus	125-130
17518712-0	2007	Alginate encapsulation impacts the insulin-like growth factor-I system of monolayer-expanded equine articular chondrocytes and cell response to interleukin-1beta.	Alginates	0-8	insulin like growth factor 1	Equus caballus	35-63
17498857-0	2007	Oral administration of BCG encapsulated in alginate microspheres induces strong Th1 response in BALB/c mice.	Alginates	43-51	negative elongation factor complex member C/D, Th1l	Mus musculus	80-83
17518712-0	2007	Alginate encapsulation impacts the insulin-like growth factor-I system of monolayer-expanded equine articular chondrocytes and cell response to interleukin-1beta.	Alginates	0-8	interleukin-1 beta	Equus caballus	144-161
17552032-6	2007	Angiogenesis was apparently inhibited within the tumor tissues, and the vascularization of alginate beads was also reduced in the mice passively transfused with anti-endoglin mAb.	Alginates	91-99	endoglin	Mus musculus	166-174
17257670-5	2007	Expansion of rat BMSCs in the presence of FGF-2 increased production of sGAG in TGF-beta1-treated groups over those cultures that were treated with TGF-beta1 alone in alginate cultures.	Alginates	167-175	fibroblast growth factor 2	Rattus norvegicus	42-47
17145144-8	2007	As for the alginate-modified nanoparticles, a smaller size and lower zeta potential were observed and the burst release of BSA was reduced.	Alginates	11-19	albumin	Bos taurus	123-126
17439723-9	2007	hASC were released from the induced cell pellets when embedded in alginate gel (implanted cell concentration=5X10(6) /mL or higher).	Alginates	66-74	PYD and CARD domain containing	Homo sapiens	0-4
17439723-12	2007	Predifferentiated hASC embedded in alginate gel have the ability of producing neocartilage in vivo.	Alginates	35-43	PYD and CARD domain containing	Homo sapiens	18-22
17428192-3	2007	The hMSCs/alginate layer was cultured in a chondrogenic defined medium and treated with transforming growth factor-beta1 (TGF-beta1) and/or LIUS for 2 weeks.	Alginates	10-18	transforming growth factor beta 1	Homo sapiens	88-120
17428192-3	2007	The hMSCs/alginate layer was cultured in a chondrogenic defined medium and treated with transforming growth factor-beta1 (TGF-beta1) and/or LIUS for 2 weeks.	Alginates	10-18	transforming growth factor beta 1	Homo sapiens	122-131
17001630-2	2007	The procedure involves the dispersion of alginate solution containing insulin protein, into a water immiscible phase.	Alginates	41-49	insulin	Homo sapiens	70-77
17001630-11	2007	In vitro release studies showed that alginate itself was not able to suppress insulin release in acidic media; however, this strategy preserves the secondary structure of insulin.	Alginates	37-45	insulin	Homo sapiens	171-178
17257670-5	2007	Expansion of rat BMSCs in the presence of FGF-2 increased production of sGAG in TGF-beta1-treated groups over those cultures that were treated with TGF-beta1 alone in alginate cultures.	Alginates	167-175	transforming growth factor, beta 1	Rattus norvegicus	148-157
17126570-0	2007	Synergistic effect of IGF-1 and OP-1 on matrix formation by normal and OA chondrocytes cultured in alginate beads.	Alginates	99-107	bone morphogenetic protein 7	Homo sapiens	32-36
17166234-8	2007	Exposure of cells to a P. aeruginosa mutant strain producing alginate reduced CCTalpha promoter activity, whereas these effects were not observed in strains defective in alginate synthesis.	Alginates	61-69	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	78-86
17242930-1	2007	A new method for immobilization of acetylcholinesterase (AChE) to alginate gel beads by activating the carbonyl groups of alginate using carbodiimide coupling agent has been successfully developed.	Alginates	66-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-55
17432950-0	2007	The in vitro expression and secretion of vascular endothelial growth factor from free and alginate-polyornithine encapsulated choroid plexus epithelium.	Alginates	90-98	vascular endothelial growth factor A	Homo sapiens	41-75
17242930-1	2007	A new method for immobilization of acetylcholinesterase (AChE) to alginate gel beads by activating the carbonyl groups of alginate using carbodiimide coupling agent has been successfully developed.	Alginates	66-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-61
17242930-1	2007	A new method for immobilization of acetylcholinesterase (AChE) to alginate gel beads by activating the carbonyl groups of alginate using carbodiimide coupling agent has been successfully developed.	Alginates	122-130	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-55
17242930-1	2007	A new method for immobilization of acetylcholinesterase (AChE) to alginate gel beads by activating the carbonyl groups of alginate using carbodiimide coupling agent has been successfully developed.	Alginates	122-130	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-61
17321862-8	2007	CONCLUSION: BMP-2 and -7 significantly increase production of extracellular matrix by septal chondrocytes suspended in alginate.	Alginates	119-127	bone morphogenetic protein 2	Homo sapiens	12-17
17156984-2	2007	In the current work albumin, lysozyme and chymotrypsin were encapsulated into alginate microspheres using a novel method that involved soaking the microspheres in a protein-containing NaCl solution.	Alginates	78-86	lysozyme	Homo sapiens	29-37
17101268-0	2007	Probing insulin"s secondary structure after entrapment into alginate/chitosan nanoparticles.	Alginates	60-68	insulin	Homo sapiens	8-15
17334282-10	2007	When grown in alginate with TFG-beta1, passage 7 cells that received FGF-2 during culture expansion restored the mRNA expression of type II collagen, Sox-9, COMP, chondroadherin, and fibromodulin.	Alginates	14-22	fibroblast growth factor 2	Bos taurus	69-74
17335402-2	2007	Using a conventional alginate-poli-L-ornithine encapsulation procedure, which has been used in our laboratory for almost two decades to envelop pancreatic islets, we observed significant loss of Sertoli cell viability, possibly due to excessive Ca(2+) ion exposure.	Alginates	21-29	DNA polymerase iota	Homo sapiens	30-34
16982090-8	2007	Results suggest that cell density and alginate concentration at high cell density can significantly affect the endogenous IGF-1 expression by chondrocytes.	Alginates	38-46	insulin like growth factor 1	Bos taurus	122-127
17101268-1	2007	The aim of the present study was to probe the structural integrity of insulin after being entrapped into chitosan/alginate nanoparticles produced by ionotropic polyelectrolyte pre-gelation.	Alginates	114-122	insulin	Homo sapiens	70-77
17471768-7	2007	The upstream effects of acidified deoxycholic acid on E-cadherin, beta-catenin and Tcf signalling were also suppressed by alginate.	Alginates	122-130	catenin beta 1	Homo sapiens	66-78
17471768-7	2007	The upstream effects of acidified deoxycholic acid on E-cadherin, beta-catenin and Tcf signalling were also suppressed by alginate.	Alginates	122-130	hepatocyte nuclear factor 4 alpha	Homo sapiens	83-86
17471768-6	2007	All alginates tested were able to prevent the induction of c-myc by acidified deoxycholic acid in vitro.	Alginates	4-13	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	59-64
17471768-7	2007	The upstream effects of acidified deoxycholic acid on E-cadherin, beta-catenin and Tcf signalling were also suppressed by alginate.	Alginates	122-130	cadherin 1	Homo sapiens	54-64
17623557-0	2007	Controlled release of vascular endothelial growth factor from alginate hydrogels nano-coated with polyelectrolyte multilayer films.	Alginates	62-70	vascular endothelial growth factor A	Homo sapiens	22-56
16680730-8	2007	Our results demonstrate the feasibility of employing alginate scaffolds to efficiently entrap and support PA317/STK cells for cancer gene therapy.	Alginates	53-61	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	Mus musculus	112-115
17623557-1	2007	Alginate (ALG) hydrogels incorporating vascular endothelial growth factor (VEGF) were nano-coated with polyelectrolyte multilayer (PEM) films composed of chitosan (CT) and dextran sulfate (DEX) in order to control the VEGF release from the hydrogels.	Alginates	0-8	vascular endothelial growth factor A	Homo sapiens	39-73
17623557-1	2007	Alginate (ALG) hydrogels incorporating vascular endothelial growth factor (VEGF) were nano-coated with polyelectrolyte multilayer (PEM) films composed of chitosan (CT) and dextran sulfate (DEX) in order to control the VEGF release from the hydrogels.	Alginates	0-8	vascular endothelial growth factor A	Homo sapiens	75-79
17019681-5	2007	The expression of osteogenic genes, including Cbfa1 and osteopontin, in the alginate beads was determined by reverse transcription-polymerase chain reaction (RT-PCR) analysis.	Alginates	76-84	osteopontin	Oryctolagus cuniculus	56-67
16957022-8	2006	Alginate scaffold concentration also affected the proliferation and differentiation of somatic cells (theca and granulosa cells), measured in terms of morphological changes, steroid profiles (androstenedione, estradiol, and progesterone), and specific molecular markers (Fshr, Lhcgr, and Gja1).	Alginates	0-8	follicle stimulating hormone receptor	Homo sapiens	271-275
17516249-0	2007	Optimization of alpha-amylase immobilization in calcium alginate beads.	Alginates	48-64	alpha-amylase	Solanum tuberosum	16-29
17516249-1	2007	alpha-Amylase enzyme was produced by Aspergillus sclerotiorum under SSF conditions, and immobilized in calcium alginate beads.	Alginates	103-119	alpha-amylase	Solanum tuberosum	0-13
17050539-3	2006	Here we show that endogenous SOX9 mRNA can be rapidly up-regulated in subcultured human articular chondrocytes if grown in alginate, in monolayer with cytochalasin D, or with specific inhibition of the RhoA effector kinases ROCK1 and -2, which all prevent actin stress fiber formation.	Alginates	123-131	SRY-box transcription factor 9	Homo sapiens	29-33
16957022-8	2006	Alginate scaffold concentration also affected the proliferation and differentiation of somatic cells (theca and granulosa cells), measured in terms of morphological changes, steroid profiles (androstenedione, estradiol, and progesterone), and specific molecular markers (Fshr, Lhcgr, and Gja1).	Alginates	0-8	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	277-282
16957022-8	2006	Alginate scaffold concentration also affected the proliferation and differentiation of somatic cells (theca and granulosa cells), measured in terms of morphological changes, steroid profiles (androstenedione, estradiol, and progesterone), and specific molecular markers (Fshr, Lhcgr, and Gja1).	Alginates	0-8	gap junction protein alpha 1	Homo sapiens	288-292
17020580-0	2006	Cell wall-inhibitory antibiotics activate the alginate biosynthesis operon in Pseudomonas aeruginosa: Roles of sigma (AlgT) and the AlgW and Prc proteases.	Alginates	46-54	AlgW protein	Pseudomonas aeruginosa PAO1	132-136
17081643-5	2006	The present paper investigates the long-term functionality and biocompatibility of murine erythropoietin (EPO) secreting C2C12 cells entrapped in microcapsules elaborated with alginates with different properties (purity, composition and viscosity).	Alginates	176-185	erythropoietin	Mus musculus	90-104
17081643-5	2006	The present paper investigates the long-term functionality and biocompatibility of murine erythropoietin (EPO) secreting C2C12 cells entrapped in microcapsules elaborated with alginates with different properties (purity, composition and viscosity).	Alginates	176-185	erythropoietin	Mus musculus	106-109
17081643-8	2006	Although EPO delivery may be limited by the formation of a fibrotic layer around non-biomedical grade alginate microcapsules, the high EPO secretion of the encapsulated cells together with the pharmacodynamic behaviour and the angiogenic and immune-modulatory properties of EPO result in no direct correlation between the biocompatibility of the alginate and the therapeutic response obtained.	Alginates	102-110	erythropoietin	Mus musculus	9-12
17081643-8	2006	Although EPO delivery may be limited by the formation of a fibrotic layer around non-biomedical grade alginate microcapsules, the high EPO secretion of the encapsulated cells together with the pharmacodynamic behaviour and the angiogenic and immune-modulatory properties of EPO result in no direct correlation between the biocompatibility of the alginate and the therapeutic response obtained.	Alginates	346-354	erythropoietin	Mus musculus	9-12
16883582-7	2006	Cells cultured in alginate responded to BMP-2 by increased synthesis of proteoglycan (PG), a major matrix molecule of cartilage.	Alginates	18-26	bone morphogenetic protein 2	Mus musculus	40-45
16883582-8	2006	IL-1 treatment of cells in alginate results in increased release of PG into the conditioned media.	Alginates	27-35	interleukin 1 complex	Mus musculus	0-4
17518626-10	2006	Applied to the alginate/MSC layer, the CCL system enhanced the synthesis of cartilage-specific matrix proteins and the chondrogenic markers, such as aggrecan, type II collagen, and Sox9.	Alginates	15-23	LOW QUALITY PROTEIN: transcription factor SOX-9	Oryctolagus cuniculus	181-185
16952452-0	2006	Insulin encapsulation in reinforced alginate microspheres prepared by internal gelation.	Alginates	36-44	insulin	Homo sapiens	0-7
17020580-10	2006	Overexpression of algW in PAO1 resulted in a mucoid phenotype and alginate production, even in the absence of cell wall stress, suggesting that AlgW protease plays a role in sigma22 activation.	Alginates	66-74	AlgW protein	Pseudomonas aeruginosa PAO1	18-22
16672984-7	2006	The combination of pORF-MIG and low-dose cisplatin produced significant antitumor activity, with complete tumor regression in 4/10 of CT26 colon carcinomas and 3/10 of LL/2c lung carcinomas, low vascularity, in alginate capsules, apparently degraded tumor microvessel density, and increased induction of apoptotic and CTL activities compared with either treatment alone.	Alginates	211-219	chemokine (C-X-C motif) ligand 9	Mus musculus	19-27
16389645-8	2006	The method was further tested for the determination of the association efficiency of insulin to nanoparticulate carriers composed of alginate and chitosan, as well as its loading capacity for this protein.	Alginates	133-141	insulin	Homo sapiens	85-92
16545947-0	2006	A biosystem for alginate metabolism in Agrobacterium tumefaciens strain C58: molecular identification of Atu3025 as an exotype family PL-15 alginate lyase.	Alginates	16-24	DUF4962 domain-containing protein	Agrobacterium fabrum str. C58	105-112
16545947-9	2006	Atu3025 released monosaccharides specifically from alginate most efficiently at pH 7.3 and 30 degrees C through a beta-elimination reaction, indicating that Atu3025 is an exotype alginate lyase potentially involved in the assimilation of LMW alginate in strain C58.	Alginates	51-59	DUF4962 domain-containing protein	Agrobacterium fabrum str. C58	157-164
16545947-6	2006	Strain C58 cells grew significantly on low-molecular-weight (LMW) alginate (average molecular weight, 1000), and we detected specific alginate-induced expression of Atu3024 and Atu3025.	Alginates	134-142	extracellular solute-binding protein	Agrobacterium fabrum str. C58	165-172
16545947-9	2006	Atu3025 released monosaccharides specifically from alginate most efficiently at pH 7.3 and 30 degrees C through a beta-elimination reaction, indicating that Atu3025 is an exotype alginate lyase potentially involved in the assimilation of LMW alginate in strain C58.	Alginates	179-187	DUF4962 domain-containing protein	Agrobacterium fabrum str. C58	0-7
16545947-6	2006	Strain C58 cells grew significantly on low-molecular-weight (LMW) alginate (average molecular weight, 1000), and we detected specific alginate-induced expression of Atu3024 and Atu3025.	Alginates	134-142	DUF4962 domain-containing protein	Agrobacterium fabrum str. C58	177-184
16545947-9	2006	Atu3025 released monosaccharides specifically from alginate most efficiently at pH 7.3 and 30 degrees C through a beta-elimination reaction, indicating that Atu3025 is an exotype alginate lyase potentially involved in the assimilation of LMW alginate in strain C58.	Alginates	179-187	DUF4962 domain-containing protein	Agrobacterium fabrum str. C58	157-164
16545947-9	2006	Atu3025 released monosaccharides specifically from alginate most efficiently at pH 7.3 and 30 degrees C through a beta-elimination reaction, indicating that Atu3025 is an exotype alginate lyase potentially involved in the assimilation of LMW alginate in strain C58.	Alginates	51-59	DUF4962 domain-containing protein	Agrobacterium fabrum str. C58	0-7
17274366-14	2006	Alginate bead analysis of in vivo neoangiogenesis showed that the inhibition reached 50% in mice vaccinated with DC-sVEGFR-2 compared with mice vaccinated with DC, DC-vector or PBS.	Alginates	0-8	kinase insert domain protein receptor	Mus musculus	116-124
16827577-1	2006	Alginate with long strictly alternating sequences of mannuronic (M) and guluronic (G) acid residues, F(G) = 0.47 and F(GG) = 0.0, was prepared by incubating mannuronan with the recombinant C-5 epimerase AlgE4.	Alginates	0-8	complement C5	Homo sapiens	189-192
16500703-4	2006	Coating of alginate-based ACH with the extracellular matrix components collagen, fibronectin, poly L-ornithine and laminin did not alter the axon regrowth response as compared to uncoated alginate-based ACH.	Alginates	11-19	fibronectin 1	Rattus norvegicus	81-92
16815293-0	2006	In vitro evaluation of alginate encapsulated adipose-tissue stromal cells for use as injectable bone graft substitute.	Alginates	23-31	WD and tetratricopeptide repeats 1	Mus musculus	45-52
16815293-1	2006	This study aims to investigate the survival and osteogenic behavior of murine-derived adipose-tissue stromal cells (ATSCs) encapsulated in alginate microcapsules thereby instigating further studies in this cell delivery strategy for in vivo osteogenesis.	Alginates	139-147	WD and tetratricopeptide repeats 1	Mus musculus	86-93
16690202-5	2006	For example, by considering the formation reaction (am)H(i)+2L=(am)L(2)H(i) we found log K(i)=6.0, 6.5 and 10.8 for i=1, 2 and 3, respectively, in the system alginate-spermidine.	Alginates	158-166	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	116-128
20799207-3	2006	By contrast, the diffusion of large molecules, including insulin like growth factor-1 (IGF-1), human growth hormone and bovine serum albumin was impeded by alginate.	Alginates	156-164	insulin like growth factor 1	Homo sapiens	57-85
16596585-7	2006	The N-cadherin expression was inhibited in the alginate, implying that decrease in cell-to-cell contacts may maintain chondrocyte activity.	Alginates	47-55	cadherin 2	Homo sapiens	4-14
16649180-4	2006	Adenovirus (Ad)-BMP-2 and Ad-BMP-6 transduction resulted in abundant BMP-2 and BMP-6 mRNA and protein expression in monolayer culture and BMP-2 protein expression in alginate cultures.	Alginates	166-174	bone morphogenetic protein 2	Homo sapiens	16-21
16649180-4	2006	Adenovirus (Ad)-BMP-2 and Ad-BMP-6 transduction resulted in abundant BMP-2 and BMP-6 mRNA and protein expression in monolayer culture and BMP-2 protein expression in alginate cultures.	Alginates	166-174	bone morphogenetic protein 6	Homo sapiens	29-34
16649180-10	2006	BMP-2-transduced stem cells suspended in alginate culture may be a practical carrier system to support bone formation in vivo.	Alginates	41-49	bone morphogenetic protein 2	Homo sapiens	0-5
16649180-11	2006	BMP-6 induced a less robust cellular response than BMP-2, particularly in alginate culture.	Alginates	74-82	bone morphogenetic protein 6	Homo sapiens	0-5
16649180-11	2006	BMP-6 induced a less robust cellular response than BMP-2, particularly in alginate culture.	Alginates	74-82	bone morphogenetic protein 2	Homo sapiens	51-56
16846338-0	2006	Mesenchymal stem cells maintain TGF-beta-mediated chondrogenic phenotype in alginate bead culture.	Alginates	76-84	transforming growth factor beta 1	Homo sapiens	32-40
16846341-3	2006	We hypothesized that culturing cells from the superficial (S) zone in two-dimensional monolayer or three-dimensional alginate would affect their synthesis of PRG4, and that subsequently seeding them atop alginate-recovered cells from the middle/ deep (M) zone in various proportions would result in tissue-engineered constructs with varying levels of PRG4 secretion and matrix accumulation.	Alginates	117-125	proteoglycan 4	Homo sapiens	158-162
16846341-3	2006	We hypothesized that culturing cells from the superficial (S) zone in two-dimensional monolayer or three-dimensional alginate would affect their synthesis of PRG4, and that subsequently seeding them atop alginate-recovered cells from the middle/ deep (M) zone in various proportions would result in tissue-engineered constructs with varying levels of PRG4 secretion and matrix accumulation.	Alginates	204-212	proteoglycan 4	Homo sapiens	158-162
16846341-3	2006	We hypothesized that culturing cells from the superficial (S) zone in two-dimensional monolayer or three-dimensional alginate would affect their synthesis of PRG4, and that subsequently seeding them atop alginate-recovered cells from the middle/ deep (M) zone in various proportions would result in tissue-engineered constructs with varying levels of PRG4 secretion and matrix accumulation.	Alginates	204-212	proteoglycan 4	Homo sapiens	351-355
16846341-4	2006	During monolayer culture, S cells retained their PRG4-secreting phenotype, whereas in alginate culture the percentage of cells secreting PRG4 decreased with time.	Alginates	86-94	proteoglycan 4	Homo sapiens	137-141
16846341-6	2006	PRG4-secreting cells were localized to the S-cell seeded construct surface, with secretion rates of 0.1-4 pg/cell/day or 0.1-1 pg/cell/day for constructs formed with monolayer-recovered or alginate-recovered S cells, respectively.	Alginates	189-197	proteoglycan 4	Homo sapiens	0-4
16392134-6	2006	Alginate hydrogel also inhibited outgrowth of DRG neurites, although this effect was attenuated by addition of fibronectin, SCs, or BMSCs.	Alginates	0-8	fibronectin 1	Homo sapiens	111-122
16487516-2	2006	Initial in vitro evaluation of calcium alginate prolonged-release-capsules (PRC) proved a consistent release of BDNF for a minimum of 8 weeks.	Alginates	31-47	brain-derived neurotrophic factor	Rattus norvegicus	112-116
20799207-3	2006	By contrast, the diffusion of large molecules, including insulin like growth factor-1 (IGF-1), human growth hormone and bovine serum albumin was impeded by alginate.	Alginates	156-164	insulin like growth factor 1	Homo sapiens	87-92
20799207-3	2006	By contrast, the diffusion of large molecules, including insulin like growth factor-1 (IGF-1), human growth hormone and bovine serum albumin was impeded by alginate.	Alginates	156-164	growth hormone 1	Homo sapiens	101-115
20799207-3	2006	By contrast, the diffusion of large molecules, including insulin like growth factor-1 (IGF-1), human growth hormone and bovine serum albumin was impeded by alginate.	Alginates	156-164	albumin	Homo sapiens	127-140
16514637-1	2006	The purpose of this study was to investigate the influence of hydrostatic pressure (HP) on apoptosis and expression of heat-shock protein 70 (HSP70) in chondrocytes cultured in alginate beads.	Alginates	177-185	LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like	Oryctolagus cuniculus	119-140
16771648-0	2006	Enhancing the drug metabolism activities of C3A--a human hepatocyte cell line--by tissue engineering within alginate scaffolds.	Alginates	108-116	complement C3	Homo sapiens	44-47
16771648-2	2006	Cultivation of C3A cells within alginate scaffolds induced the formation of spheroids with enhanced drug metabolism activities compared to that of two-dimensional (2-D) monolayer cultures.	Alginates	32-40	complement C3	Homo sapiens	15-18
16514637-1	2006	The purpose of this study was to investigate the influence of hydrostatic pressure (HP) on apoptosis and expression of heat-shock protein 70 (HSP70) in chondrocytes cultured in alginate beads.	Alginates	177-185	LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like	Oryctolagus cuniculus	142-147
16514654-9	2006	In addition, expression of Connexin 43 (Cx43) mRNA was slightly lower in alginate than in pellet cultures and was not significantly altered by loading.	Alginates	73-81	gap junction protein alpha 1	Sus scrofa	27-38
16514654-9	2006	In addition, expression of Connexin 43 (Cx43) mRNA was slightly lower in alginate than in pellet cultures and was not significantly altered by loading.	Alginates	73-81	gap junction protein alpha 1	Sus scrofa	40-44
16324853-0	2006	Osteogenic protein-1 promotes the formation of tissue-engineered cartilage using the alginate-recovered-chondrocyte method.	Alginates	85-93	bone morphogenetic protein 7	Homo sapiens	0-20
16324853-1	2006	OBJECTIVE: This study examined the effects of a growth factor, recombinant human osteogenic protein-1 (rhOP-1), on the formation of tissue-engineered cartilaginous tissue by adult bovine articular chondrocytes using the alginate-recovered-chondrocyte (ARC) method.	Alginates	220-228	bone morphogenetic protein 7	Homo sapiens	81-101
16442757-0	2006	Alginate microspheres prepared by internal gelation: development and effect on insulin stability.	Alginates	0-8	insulin	Homo sapiens	79-86
16442757-1	2006	Recombinant human insulin was encapsulated within alginate microspheres by the emulsification/internal gelation technique with the objective of preserving protein stability during encapsulation procedure.	Alginates	50-58	insulin	Homo sapiens	18-25
16442757-5	2006	Insulin encapsulation efficiency, near 75%, was not affected by emulsifier concentration, mixer rotational speed and zinc/insulin hexamer molar ratio but decreased either by increasing internal phase ratio and calcium/alginate mass ratio or by decreasing acid/calcium molar ratio and alginate concentration.	Alginates	218-226	insulin	Homo sapiens	0-7
16442757-5	2006	Insulin encapsulation efficiency, near 75%, was not affected by emulsifier concentration, mixer rotational speed and zinc/insulin hexamer molar ratio but decreased either by increasing internal phase ratio and calcium/alginate mass ratio or by decreasing acid/calcium molar ratio and alginate concentration.	Alginates	284-292	insulin	Homo sapiens	0-7
16442757-7	2006	Extracted insulin from microspheres decreased hyperglycemia of diabetic rats proving to be bioactive and showing that encapsulation in alginate microspheres using the emulsification/internal gelation is an appropriate method for protein encapsulation.	Alginates	135-143	insulin	Homo sapiens	10-17
16188312-7	2006	Intercellular molecules such as connexin32 and E-cadherin genes related with cell-cell contact were expressed in hepatocytes within AL/GC sponge at 36 h after incubation, but not in AL sponge.	Alginates	132-134	gap junction protein beta 1	Homo sapiens	32-42
16219457-6	2006	A major finding was that the application of {PSS/PAH} films as thin as 12 nm can drastically improve the sensor performance over uncoated sensors based on calcium alginate microspheres.	Alginates	155-171	phenylalanine hydroxylase	Homo sapiens	49-52
16188312-7	2006	Intercellular molecules such as connexin32 and E-cadherin genes related with cell-cell contact were expressed in hepatocytes within AL/GC sponge at 36 h after incubation, but not in AL sponge.	Alginates	132-134	cadherin 1	Homo sapiens	47-57
16188312-7	2006	Intercellular molecules such as connexin32 and E-cadherin genes related with cell-cell contact were expressed in hepatocytes within AL/GC sponge at 36 h after incubation, but not in AL sponge.	Alginates	182-184	cadherin 1	Homo sapiens	47-57
16352829-3	2006	This study demonstrates that AlgZ, previously identified as a DNA-binding protein absolutely required for transcription of the alginate biosynthetic operon, is required for twitching motility.	Alginates	127-135	alginate biosynthesis protein AlgZ/FimS	Pseudomonas aeruginosa PAO1	29-33
16912431-7	2006	Intracellular IL-1beta production was analysed in articular chondrocytes cultured in monolayer or in alginate 3D-biosystems in the presence of lipopolysaccharide (LPS) or IL-1alpha, with or without diacerein.	Alginates	101-109	interleukin 1 beta	Homo sapiens	14-22
16515800-4	2006	The binding properties of alginate with divalent cations have been studied, showing an increasing affinity for Ca2+ over Mg2+ as polymer concentration increases, and the relative affinity Pb2+ &gt; or = Cu2+ &gt; Zn2+ &gt; Ni2+.	Alginates	26-34	mucin 7, secreted	Homo sapiens	121-124
16352829-9	2006	These data show that AlgZ DNA-binding activity is required for twitching motility independently of its role in alginate production and that this involves the surface localization of type IV pili.	Alginates	111-119	alginate biosynthesis protein AlgZ/FimS	Pseudomonas aeruginosa PAO1	21-25
16352829-10	2006	Given this new role in twitching motility, we propose that algZ (PA3385) be designated amrZ (alginate and motility regulator Z).	Alginates	93-101	alginate biosynthesis protein AlgZ/FimS	Pseudomonas aeruginosa PAO1	59-63
16320338-7	2005	Likewise, sulfate incorporation in response to IGF-1 and OP-1 alone or together was completely inhibited by 50 ng/ml bFGF in both alginate and explant cultures.	Alginates	130-138	insulin like growth factor 1	Homo sapiens	47-52
16246317-1	2005	Alginates are (1--&gt;4)-linked structural copolyuronans consisting of beta-D-mannuronic acid (M) and its C-5 epimer alpha-L-guluronic acid (G).	Alginates	0-9	complement C5	Homo sapiens	106-109
16097039-3	2006	METHODS: Lapine articular chondrocytes overexpressing a lacZ or a human FGF-2 gene sequence were encapsulated in alginate and further characterized.	Alginates	113-121	fibroblast growth factor 2	Homo sapiens	72-77
16499440-9	2006	Connexin32 and E-cadherin genes correlated with cell-to-cell adhesion were expressed in hepatocytes within AL/GC and AL/GC/heparin sponges at 36 h after incubation, but not in AL sponges.	Alginates	107-109	gap junction protein beta 1	Homo sapiens	0-10
16499440-9	2006	Connexin32 and E-cadherin genes correlated with cell-to-cell adhesion were expressed in hepatocytes within AL/GC and AL/GC/heparin sponges at 36 h after incubation, but not in AL sponges.	Alginates	107-109	cadherin 1	Homo sapiens	15-25
16499440-11	2006	In the presence of HGF, the level of albumin secretion in AL/GC/heparin sponges was markedly elevated compared to that in AL/GC sponges.	Alginates	58-60	hepatocyte growth factor	Homo sapiens	19-22
16320338-7	2005	Likewise, sulfate incorporation in response to IGF-1 and OP-1 alone or together was completely inhibited by 50 ng/ml bFGF in both alginate and explant cultures.	Alginates	130-138	bone morphogenetic protein 7	Homo sapiens	57-61
16320338-7	2005	Likewise, sulfate incorporation in response to IGF-1 and OP-1 alone or together was completely inhibited by 50 ng/ml bFGF in both alginate and explant cultures.	Alginates	130-138	fibroblast growth factor 2	Homo sapiens	117-121
16242925-1	2005	The graft copolymer (APN) of alginate and poly(N-isopropylacrylamide) (PNIPAM) were synthesized and APN beads were prepared by dropping the aqueous solution of the copolymer into an aqueous solution of Ca(2+) solution.	Alginates	29-37	alanyl aminopeptidase, membrane	Homo sapiens	21-24
16301659-0	2005	The exopolysaccharide alginate protects Pseudomonas aeruginosa biofilm bacteria from IFN-gamma-mediated macrophage killing.	Alginates	22-30	interferon gamma	Homo sapiens	85-94
16301659-6	2005	Human leukocytes, in the presence of recombinant human IFN-gamma, killed biofilm bacteria lacking alginate after a 4-h challenge at 37 degrees C. Bacterial killing was dependent on the presence of IFN-gamma.	Alginates	98-106	interferon gamma	Homo sapiens	55-64
16301659-8	2005	By direct microscopic observation, phagocytosis of alginate-negative biofilm bacteria was significantly increased in the presence of IFN-gamma vs all other treatments.	Alginates	51-59	interferon gamma	Homo sapiens	133-142
15987824-5	2005	Two-layered secondary follicles were FSH responsive when cultured in alginate-collagen I matrices, exhibiting FSH dose-dependent increases in follicle growth, lactate production, and steroid secretion.	Alginates	69-77	follicle stimulating hormone beta	Mus musculus	37-40
16274740-1	2005	In this study, a new matrix for immobilization of acetylcholinesterase was investigated by using alginate and kappa-carrageenan.	Alginates	97-105	acetylcholinesterase (Cartwright blood group)	Homo sapiens	50-70
15987824-5	2005	Two-layered secondary follicles were FSH responsive when cultured in alginate-collagen I matrices, exhibiting FSH dose-dependent increases in follicle growth, lactate production, and steroid secretion.	Alginates	69-77	follicle stimulating hormone beta	Mus musculus	110-113
16267280-2	2005	We showed here that a mutation in zwf, encoding glucose-6-phosphate dehydrogenase (G6PDH), leads to a approximately 90% reduction in alginate production in the mucoid, CF isolate, P. aeruginosa FRD1.	Alginates	133-141	glucose-6-phosphate 1-dehydrogenase	Pseudomonas aeruginosa PAO1	34-37
16283760-5	2005	In addition, biosensors were prepared by entrapment of the PPO in polypyrrole-alginate and regular alginate matrixes and their performance for the amperometric determination of catechol chosen as a model analyte was examined, yielding a sensitivity of 350 and 80 microA M(-1) cm(-2), respectively, for polypyrrole-alginate and alginate biosensors.	Alginates	78-86	protoporphyrinogen oxidase	Homo sapiens	59-62
16287241-0	2005	Combined physical and chemical immobilization of glucose oxidase in alginate microspheres improves stability of encapsulation and activity.	Alginates	68-76	hydroxyacid oxidase 1	Homo sapiens	49-64
16287241-3	2005	Glucose oxidase (GOx) was encapsulated in alginate microspheres using three different methods: physical entrapment (emulsion), chemical conjugation (conjugation), and a combination of physical entrapment and chemical conjugation (emulsion-conjugation).	Alginates	42-50	hydroxyacid oxidase 1	Homo sapiens	0-15
16287241-3	2005	Glucose oxidase (GOx) was encapsulated in alginate microspheres using three different methods: physical entrapment (emulsion), chemical conjugation (conjugation), and a combination of physical entrapment and chemical conjugation (emulsion-conjugation).	Alginates	42-50	hydroxyacid oxidase 1	Homo sapiens	17-20
16287241-8	2005	As a result, the comparison of these three techniques showed the emulsion-conjugation technique to be a potentially effective and practical way to fabricate alginate/GOx microspheres for implantable glucose biosensor application.	Alginates	157-165	hydroxyacid oxidase 1	Homo sapiens	166-169
16267280-3	2005	The main regulator of alginate, sigma-22 encoded by algT (algU), plays a small but demonstrable role in the induction of zwf expression in P. aeruginosa.	Alginates	22-30	glucose-6-phosphate 1-dehydrogenase	Pseudomonas aeruginosa PAO1	121-124
16243232-8	2005	When they were pre-incubated with IL-1beta, IL-6 or OSM, N osteoblasts inhibited AGG synthesis and increased MMP-3 and -13 gene expression by chondrocytes in alginate beads in a same order of magnitude as SC osteoblasts.	Alginates	158-166	interleukin 1 beta	Homo sapiens	34-42
15966019-4	2005	METHODS: In this study we evaluated the intraperitoneal implantation of allogeneic myoblasts over-expressing IDS, enclosed in alginate microcapsules, in the MPS II mouse model.	Alginates	126-134	iduronate 2-sulfatase	Mus musculus	109-112
16243232-8	2005	When they were pre-incubated with IL-1beta, IL-6 or OSM, N osteoblasts inhibited AGG synthesis and increased MMP-3 and -13 gene expression by chondrocytes in alginate beads in a same order of magnitude as SC osteoblasts.	Alginates	158-166	interleukin 6	Homo sapiens	44-48
16243232-8	2005	When they were pre-incubated with IL-1beta, IL-6 or OSM, N osteoblasts inhibited AGG synthesis and increased MMP-3 and -13 gene expression by chondrocytes in alginate beads in a same order of magnitude as SC osteoblasts.	Alginates	158-166	matrix metallopeptidase 3	Homo sapiens	109-122
16153116-1	2005	The Pb and Cd binding capacity of alginates were quantified by the determination of their complex stability constants and the concentration of complexing sites using H+, Pb2+, or Cd2+ selective electrodes in both static and dynamic titrations.	Alginates	34-43	CD2 molecule	Homo sapiens	179-182
28853944-4	2005	Furthermore, among these death receptor-derived peptides, marked neurite outgrowth was observed only when the neurospheres were cultured on a TNFR1-derived peptide-conjugated covalently cross-linked alginate gel.	Alginates	199-207	TNF receptor superfamily member 1A	Rattus norvegicus	142-147
28853944-6	2005	These results suggest that the TNFR1-derived peptide promotes neuronal differentiation of the hippocampal neural stem cells and the TNFR1-derived peptide-conjugated covalently cross-linked alginate gel may be a useful material for assisting neural stem cell transplantation.	Alginates	189-197	TNF receptor superfamily member 1A	Rattus norvegicus	132-137
16013059-8	2005	Accordingly, 1-week exposure to TGF-beta1 in vitro before transplantation is appropriate for neocartilage formation of human MSCs in alginate.	Alginates	133-141	transforming growth factor beta 1	Homo sapiens	32-41
16178420-4	2005	We showed that mouse peritoneal monocytes stimulated with alginate produce NO and TNF-alpha.	Alginates	58-66	tumor necrosis factor	Mus musculus	82-91
16055120-2	2005	Enzymatically depolymerized unsaturated alginate oligomers induced tumor necrosis factor (TNF)-alpha secretion from RAW264.7 cells in a structure-depending manner, while the activities of saturated alginate oligomers prepared by acid hydrolysis were fairly low or only trace levels.	Alginates	40-48	tumor necrosis factor	Mus musculus	67-100
16055120-3	2005	These results suggest that unsaturated end-structure of alginate oligomers was important for the TNF-alpha-inducing activity.	Alginates	56-64	tumor necrosis factor	Mus musculus	97-106
16055120-7	2005	Since antibodies to Toll-like receptor (TLR)2 and TLR4 effectively inhibited the G8- and M7-induced production of TNF-alpha, these alginate oligomers may stimulate innate immunity through the pattern recognition receptors on macrophages similar to microbial products.	Alginates	131-139	toll-like receptor 2	Mus musculus	40-45
16055120-7	2005	Since antibodies to Toll-like receptor (TLR)2 and TLR4 effectively inhibited the G8- and M7-induced production of TNF-alpha, these alginate oligomers may stimulate innate immunity through the pattern recognition receptors on macrophages similar to microbial products.	Alginates	131-139	toll-like receptor 4	Mus musculus	50-54
16055120-7	2005	Since antibodies to Toll-like receptor (TLR)2 and TLR4 effectively inhibited the G8- and M7-induced production of TNF-alpha, these alginate oligomers may stimulate innate immunity through the pattern recognition receptors on macrophages similar to microbial products.	Alginates	131-139	tumor necrosis factor	Mus musculus	114-123
15801908-7	2005	Instead, in alginate- cultured chondrocytes, the MEK inhibitors increased IGF-I-stimulated proteoglycan synthesis when compared with cells treated with IGF-I alone.	Alginates	12-20	mitogen-activated protein kinase kinase 7	Homo sapiens	49-52
15801908-7	2005	Instead, in alginate- cultured chondrocytes, the MEK inhibitors increased IGF-I-stimulated proteoglycan synthesis when compared with cells treated with IGF-I alone.	Alginates	12-20	insulin like growth factor 1	Homo sapiens	74-79
16178420-5	2005	In addition, alginate is able also to increase their phagocytic activity and to a lesser extent also to increase the expression of CD80.	Alginates	13-21	CD80 antigen	Mus musculus	131-135
15815701-9	2005	The data indicate that allogeneic chondrocytes, transfected by a nonviral method and cultured in alginate, are able to secrete biologically relevant amounts of IGF-I over a prolonged period of time in vitro.	Alginates	97-105	insulin like growth factor 1	Homo sapiens	160-165
16030202-4	2005	AlgQ is a global regulatory protein which activates alginate, ppGpp, and inorganic polyphosphate synthesis through a cascade involving nucleoside diphosphate kinase (Ndk).	Alginates	52-60	anti-RNA polymerase sigma 70 factor	Pseudomonas aeruginosa PAO1	0-4
16030202-4	2005	AlgQ is a global regulatory protein which activates alginate, ppGpp, and inorganic polyphosphate synthesis through a cascade involving nucleoside diphosphate kinase (Ndk).	Alginates	52-60	nucleoside diphosphate kinase	Pseudomonas aeruginosa PAO1	135-164
16030202-4	2005	AlgQ is a global regulatory protein which activates alginate, ppGpp, and inorganic polyphosphate synthesis through a cascade involving nucleoside diphosphate kinase (Ndk).	Alginates	52-60	nucleoside diphosphate kinase	Pseudomonas aeruginosa PAO1	166-169
16030202-13	2005	AlgQ provides a link between the pyoverdine and alginate regulatory networks.	Alginates	48-56	anti-RNA polymerase sigma 70 factor	Pseudomonas aeruginosa PAO1	0-4
15664644-7	2005	Fibroblasts encapsulated in alginate beads containing 0.01% and 0.1% (w/v) 45S5 bioactive glass particles secreted increased quantities of VEGF compared with cells encapsulated with 0% or 1% (w/v) 45S5 bioactive glass particles.	Alginates	28-36	vascular endothelial growth factor A	Homo sapiens	139-143
16133713-0	2005	Comparison of the activities of various alginates to induce TNF-alpha secretion in RAW264.7 cells.	Alginates	40-49	tumor necrosis factor	Mus musculus	60-69
16133713-1	2005	We compared the abilities of alginate polymers having different molecular sizes and compositions to induce the secretion of tumor necrosis factor (TNF)-alpha in RAW264.7 cells.	Alginates	29-37	tumor necrosis factor	Mus musculus	124-157
16133713-6	2005	Such an effect of enzymatic digestion was also observed in a relatively low-molecular-weight alginate (ULV-3), which originally had very low TNF-alpha-inducing activity.	Alginates	93-101	tumor necrosis factor	Mus musculus	141-150
16133713-8	2005	These results suggest that the underlying mechanism of the TNF-alpha-inducing activity of enzymatically depolymerized alginate oligomers is not necessarily the same as that of original alginate polymer.	Alginates	118-126	tumor necrosis factor	Mus musculus	59-68
16133713-8	2005	These results suggest that the underlying mechanism of the TNF-alpha-inducing activity of enzymatically depolymerized alginate oligomers is not necessarily the same as that of original alginate polymer.	Alginates	185-193	tumor necrosis factor	Mus musculus	59-68
16156303-0	2005	In vitro characterization of TGF-beta1 release from genetically modified fibroblasts in Ca(2+)-alginate microcapsules.	Alginates	95-103	transforming growth factor beta 1	Homo sapiens	29-38
15664644-8	2005	Lysed alginate beads containing 0.01% and 0.1% (w/v) 45S5 bioactive glass contained significantly more VEGF (p&lt;0.01) compared with beads containing no glass particles.	Alginates	6-14	vascular endothelial growth factor A	Homo sapiens	103-107
16004466-3	2005	A calcium ion chelator, EDTA, was used to free the Ca(2+)-cross-linked alginate hydrogel within {poly(allylamine hydrochloride)/poly (styrene sulfonate)}(4) ({PAH/PSS}(4)) coating, allowing partial release of alginate.	Alginates	71-79	cystatin A	Homo sapiens	163-170
16004466-4	2005	The retention of alginate in {PAH/PSS}(4) microcapsule was confirmed by FTIR spectroscopy and confocal microscopy.	Alginates	17-25	PSS	Homo sapiens	34-37
15316628-1	2005	Local application of an alginate matrix loaded with epidermal growth factor in an animal model].	Alginates	24-32	epidermal growth factor like 1	Rattus norvegicus	52-75
16026516-10	2005	The present study demonstrated that hMSC produced numerous extracellular matrices containing abnormal collagen fibres following their exposure to a chondrogenesis-induction medium in alginate beads.	Alginates	183-191	musculin	Homo sapiens	36-40
15930360-7	2005	Antiangiogenesis of CXCL10 in vivo were determined by alginate capsule models and CD31 immunohistochemistry.	Alginates	54-62	chemokine (C-X-C motif) ligand 10	Mus musculus	20-26
15930360-10	2005	CXCL10 successfully inhibited angiogenesis as assessed by alginate model and CD31 (P &lt; 0.05).	Alginates	58-66	chemokine (C-X-C motif) ligand 10	Mus musculus	0-6
15316628-2	2005	BACKGROUND: The aim of this study was to evaluate the effects of an alginate matrix releasing epidermal growth factor on healing after acute tympanic membrane perforation in rats.	Alginates	68-76	epidermal growth factor like 1	Rattus norvegicus	94-117
15928868-2	2005	To obtain man-made ECM, the reconstitution of collagen could be conducted in the presence of negatively charged polysaccharide, such as alginate.	Alginates	136-144	multimerin 1	Homo sapiens	19-22
15891662-0	2005	Delivery of neurotrophin-3 to the cochlea using alginate beads.	Alginates	48-56	neurotrophin-3	Cavia porcellus	12-26
16214783-6	2005	The high alginate capsules, A100:P0 (100% alginate: 0% pectin) and A80:P20 (80% alginate: 20% pectin) were of regular spherical shape, while those with more pectin, A70:P30 (70% alginate: 30% pectin) and A60:P40 (60% alginate: 40% pectin) formed irregular spheres.	Alginates	9-17	centromere protein V	Homo sapiens	169-172
16214783-6	2005	The high alginate capsules, A100:P0 (100% alginate: 0% pectin) and A80:P20 (80% alginate: 20% pectin) were of regular spherical shape, while those with more pectin, A70:P30 (70% alginate: 30% pectin) and A60:P40 (60% alginate: 40% pectin) formed irregular spheres.	Alginates	9-17	interleukin 9	Homo sapiens	208-211
15893960-15	2005	These results suggest that treatment with sodium alginate as a new immunosuppressive agent can reduce proteinuria, inhibit MMP-2 activity and suppress the antibody production as well as the development of glomerular lesions in a rat model of immune complex glomerulonephritis.	Alginates	42-57	matrix metallopeptidase 2	Rattus norvegicus	123-128
15922187-0	2005	BMP-2 induces the expression of chondrocyte-specific genes in bovine synovium-derived progenitor cells cultured in three-dimensional alginate hydrogel.	Alginates	133-141	bone morphogenetic protein 2	Bos taurus	0-5
15576169-11	2005	Seeding chondrocytes in alginate beads in the presence of hPS generated a cell population capable of type II collagen expression, even though hPS induced considerable type I collagen expression as well.	Alginates	24-32	adaptor related protein complex 3 subunit beta 1	Homo sapiens	58-61
15762675-1	2005	The availability of mannuronan and mannuronan C-5 epimerases allows the production of a strictly alternating mannuronate-guluronate (MG) polymer and the MG-enrichment of natural alginates, providing a powerful tool for the analysis of the role of such sequences in the calcium-alginate gel network.	Alginates	178-187	complement C5	Homo sapiens	46-49
15778039-8	2005	In contrast, cells entrapped in alginate-cellulose sulfate matrices presented the lowest mechanical resistance, cell viability and GDNF production.	Alginates	32-40	glial cell derived neurotrophic factor	Rattus norvegicus	131-135
15669081-3	2005	The mRNA expression of tumor necrosis factor-alpha and interleukin-1beta was significantly higher when macrophages were coincubated with beads made with nonpurified compared with purified alginate (p&lt;0.01, p&lt;0.05, respectively) and negative control (p&lt;0.001) or with APA microcapsules compared with non-PLL-coated alginate beads and negative control (p&lt;0.001).	Alginates	188-196	tumor necrosis factor	Homo sapiens	23-50
15669081-3	2005	The mRNA expression of tumor necrosis factor-alpha and interleukin-1beta was significantly higher when macrophages were coincubated with beads made with nonpurified compared with purified alginate (p&lt;0.01, p&lt;0.05, respectively) and negative control (p&lt;0.001) or with APA microcapsules compared with non-PLL-coated alginate beads and negative control (p&lt;0.001).	Alginates	188-196	interleukin 1 beta	Homo sapiens	55-72
15669081-3	2005	The mRNA expression of tumor necrosis factor-alpha and interleukin-1beta was significantly higher when macrophages were coincubated with beads made with nonpurified compared with purified alginate (p&lt;0.01, p&lt;0.05, respectively) and negative control (p&lt;0.001) or with APA microcapsules compared with non-PLL-coated alginate beads and negative control (p&lt;0.001).	Alginates	323-331	tumor necrosis factor	Homo sapiens	23-50
15669081-3	2005	The mRNA expression of tumor necrosis factor-alpha and interleukin-1beta was significantly higher when macrophages were coincubated with beads made with nonpurified compared with purified alginate (p&lt;0.01, p&lt;0.05, respectively) and negative control (p&lt;0.001) or with APA microcapsules compared with non-PLL-coated alginate beads and negative control (p&lt;0.001).	Alginates	323-331	interleukin 1 beta	Homo sapiens	55-72
15762675-1	2005	The availability of mannuronan and mannuronan C-5 epimerases allows the production of a strictly alternating mannuronate-guluronate (MG) polymer and the MG-enrichment of natural alginates, providing a powerful tool for the analysis of the role of such sequences in the calcium-alginate gel network.	Alginates	178-186	complement C5	Homo sapiens	46-49
15505831-5	2004	In this study, regenerated axons in H/A gel with bFGF grew faster than in ordinary alginate gel with bFGF in the early stage.	Alginates	83-91	fibroblast growth factor 2	Rattus norvegicus	101-105
15693015-5	2005	RESULTS: Antisense treatment inhibited OP-1 gene expression by a mean +/- SD of 34 +/- 12% (P &lt; 0.01) in chondrocytes cultured in monolayers and by 77 +/- 27% (P &lt; 0.03) in alginate beads.	Alginates	179-187	bone morphogenetic protein 7	Homo sapiens	39-43
16405077-4	2005	Furthermore, among these death receptor-derived peptides, marked neurite outgrowth was observed only when the neurospheres were cultured on a TNFR1-derived peptide-conjugated covalently cross-linked alginate gel.	Alginates	199-207	TNF receptor superfamily member 1A	Rattus norvegicus	142-147
16405077-6	2005	These results suggest that the TNFR1-derived peptide promotes neuronal differentiation of the hippocampal neural stem cells and the TNFR1-derived peptide-conjugated covalently cross-linked alginate gel may be a useful material for assisting neural stem cell transplantation.	Alginates	189-197	TNF receptor superfamily member 1A	Rattus norvegicus	132-137
15665609-0	2005	Alginate encapsulated BDNF-producing fibroblast grafts permit recovery of function after spinal cord injury in the absence of immune suppression.	Alginates	0-8	brain derived neurotrophic factor	Homo sapiens	22-26
15665609-2	2005	Previously we have shown that alginate encapsulated BDNF-producing fibroblasts (Fb/BDNF) survived for one month in culture, made bioactive neurotrophins, survived transplantation into the injured spinal cord in the absence of immune suppression, and provided a permissive environment for host axon growth.	Alginates	30-38	brain derived neurotrophic factor	Homo sapiens	52-56
15665609-2	2005	Previously we have shown that alginate encapsulated BDNF-producing fibroblasts (Fb/BDNF) survived for one month in culture, made bioactive neurotrophins, survived transplantation into the injured spinal cord in the absence of immune suppression, and provided a permissive environment for host axon growth.	Alginates	30-38	brain derived neurotrophic factor	Homo sapiens	83-87
15499568-6	2004	Biotinylated fiber could be fabricated by biotinylating alginate before drawing fiber with WSC, enabling biotinylated NGF to be immobilized to fiber via an avidin bridge.	Alginates	56-64	nerve growth factor	Homo sapiens	118-121
15694150-7	2005	CONCLUSIONS: This study showed that chitosan-alginate gel/MSCs/BMP-2 composites could become clinically useful injectable materials to generate new bone.	Alginates	45-53	bone morphogenetic protein 2	Mus musculus	63-68
15629688-11	2005	In a second study, apoE was detectable in plasma of five mice treated with alginate poly-l-lysine beads, 4 and 7 days post-implantation, though not at day 14.	Alginates	75-83	apolipoprotein E	Mus musculus	19-23
15638508-2	2005	The unsubstituted M residues in the modified polymer were converted into guluronic moieties (G) by the use of two C-5 epimerases, resulting in an alginate-like molecule selectively modified on M residues.	Alginates	146-154	complement C5	Homo sapiens	114-117
15510177-10	2005	After 6 weeks, new full thickness bone was seen emanating directly from the alginate/collagen matrix in the Shh-transduced groups.	Alginates	76-84	sonic hedgehog protein	Oryctolagus cuniculus	108-111
15505831-8	2004	H/A gel with bFGF exhibited better-developed vascularization than ordinary alginate gel with bFGF.	Alginates	75-83	fibroblast growth factor 2	Rattus norvegicus	93-97
15300795-9	2004	Complete inhibition of ovarian tumor growth was observed when P125A-endostatin-RGD was encapsulated into alginate beads.	Alginates	105-113	collagen, type XVIII, alpha 1	Mus musculus	68-78
15095092-5	2004	Some anionic polysaccharides at 0.04-0.2% w/v (e.g. gum arabic, pectin and hypochlorite-oxidised xyloglucan) promoted the XET activity of de-salted enzyme, especially if a sub-optimal concentration of NaCl was also present; others (e.g. homogalacturonan, 4- O-methyl-glucuronoxylan and alginate) were inhibitory.	Alginates	286-294	xyloglucan:xyloglucosyl transferase 33	Arabidopsis thaliana	122-125
15561282-0	2004	Sustained release of vascular endothelial growth factor from calcium-induced alginate hydrogels reinforced by heparin and chitosan.	Alginates	77-85	vascular endothelial growth factor A	Homo sapiens	21-55
15561282-13	2004	Chitosan-coated alginate gels released 90% of loaded VEGF within 5 days.	Alginates	16-24	vascular endothelial growth factor A	Homo sapiens	53-57
15219571-0	2004	Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads.	Alginates	120-128	bone morphogenetic protein 2	Homo sapiens	0-34
15120902-0	2004	Sustained delivery of vascular endothelial growth factor with alginate beads.	Alginates	62-70	vascular endothelial growth factor A	Homo sapiens	22-56
15250049-6	2004	Chondrogenesis induced by TGF-beta3 in alginate bead system was confirmed by examining cartilage specific type II collagen expression and aggrecan, whereas type I collagen expression was not affected by TGF-beta3.	Alginates	39-47	transforming growth factor beta 3	Homo sapiens	26-35
15120902-4	2004	In this study, VEGF was encapsulated in calcium alginate beads by the extrusion/external gelation method, and was subsequently released in PBS and in serum media.	Alginates	40-56	vascular endothelial growth factor A	Homo sapiens	15-19
15120902-5	2004	The objective was to optimize VEGF encapsulation yield and obtain VEGF release at a constant rate from alginate matrices in vitro.	Alginates	103-111	vascular endothelial growth factor A	Homo sapiens	66-70
15120902-7	2004	The rate of VEGF release from alginate beads was higher in serum than in PBS, which was due to the capacity of the serum in reducing the electrostatic interaction between alginate and VEGF.	Alginates	30-38	vascular endothelial growth factor A	Homo sapiens	12-16
15120902-7	2004	The rate of VEGF release from alginate beads was higher in serum than in PBS, which was due to the capacity of the serum in reducing the electrostatic interaction between alginate and VEGF.	Alginates	30-38	vascular endothelial growth factor A	Homo sapiens	184-188
15120902-7	2004	The rate of VEGF release from alginate beads was higher in serum than in PBS, which was due to the capacity of the serum in reducing the electrostatic interaction between alginate and VEGF.	Alginates	171-179	vascular endothelial growth factor A	Homo sapiens	12-16
15120902-8	2004	The presence of CaCl(2) in the release supernatant can shield the alginate interaction with VEGF, and a constant release rate of 6 ng/ml/day may be sustained for 14 days.	Alginates	66-74	vascular endothelial growth factor A	Homo sapiens	92-96
15120902-9	2004	These results suggest that the alginate-VEGF delivery system may be useful in the development of vascular tissue engineering and wound healing applications.	Alginates	31-39	vascular endothelial growth factor A	Homo sapiens	40-44
15023455-3	2004	In a model bioadhesive bond formed between an alginate matrix and mucin gel, characteristic profiles were observed in which fluorescence measurements showed a region of increasing mucin concentration in the mucus layer region adjacent to the matrix, corresponding closely with a zone of restricted water SDC in the diffusion profiles.	Alginates	46-54	LOC100508689	Homo sapiens	66-71
15171478-1	2004	An alginate microcapsule was developed that contains three enzymes (urease, uricase, and creatininase) capable of effectively degrading urea, uric acid, and creatinine, which are elevated to pathologic levels in patients with kidney failure.	Alginates	3-11	urate oxidase (pseudogene)	Homo sapiens	76-83
14720556-7	2004	The adsorption of Cu(II), Co(II), and Cd(II) on the beads was significantly rapid and reached at equilibrium within 10 min at 25 degrees C. Adsorption isotherms of the metal ions on the beads exhibited Freundlich and/or Langmuir behavior, contrary to gel beads either of alginate or chitosan showing a step-wise shape of adsorption isotherm.	Alginates	271-279	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-31
15023455-3	2004	In a model bioadhesive bond formed between an alginate matrix and mucin gel, characteristic profiles were observed in which fluorescence measurements showed a region of increasing mucin concentration in the mucus layer region adjacent to the matrix, corresponding closely with a zone of restricted water SDC in the diffusion profiles.	Alginates	46-54	LOC100508689	Homo sapiens	180-185
14673993-2	2003	METHODS: Cell death induced by the oxidant SIN-1 was evaluated in the alginate bead culture system using fluorescent probes to assess membrane integrity.	Alginates	70-78	MAPK associated protein 1	Homo sapiens	43-48
15040603-1	2004	The potential benefit of continuous local administration of antiangiogenic proteins to CNS tumors in vivo has recently been demonstrated using endostatin-producing recombinant cells encapsulated in alginate beads.	Alginates	198-206	collagen type XVIII alpha 1 chain	Homo sapiens	143-153
15040603-3	2004	Alginate beads containing human embryonic kidney cells (HEK 293 cells) stably transfected with the gene encoding for endostatin were cryopreserved in dimethyl sulfoxide (DMSO) using a slow freezing procedure.	Alginates	0-8	collagen type XVIII alpha 1 chain	Homo sapiens	117-127
15754484-1	2004	The efficiency of food supplement (BAS) on the basis of calcium alginate was studied among the diseased people with virus hepatitis.	Alginates	56-72	BAS	Homo sapiens	35-38
14643615-0	2004	Development of alginate wound dressings linked with hybrid peptides derived from laminin and elastin.	Alginates	15-23	elastin	Homo sapiens	93-100
15334993-12	2004	Addition of NaF or SnF2 in an alginate impression material may result in effective release of fluoride without deteriorating the properties of material itself.	Alginates	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
15334993-12	2004	Addition of NaF or SnF2 in an alginate impression material may result in effective release of fluoride without deteriorating the properties of material itself.	Alginates	30-38	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	19-23
15165474-10	2004	Furthermore, collagen II gene expression in chondrocytes retrovirally transduced with SOX9 was stimulated by alginate bead culture, whereas in control chondrocytes it was not.	Alginates	109-117	SRY-box transcription factor 9	Homo sapiens	86-90
15508281-0	2004	Immobilization of catalase by entrapping in alginate beads and catalase biosensor preparation for the determination of hydrogen peroxide decomposition.	Alginates	44-52	catalase	Homo sapiens	18-26
15508281-1	2004	In this study, catalase enzyme was immobilized by entrapping in alginate beads in the presence of gelatin.	Alginates	64-72	catalase	Homo sapiens	15-23
14554223-2	2003	Studies on wild-type cells of murine mesenchymal C3H10T1/2 progenitor cells as well as on cells transfected with cDNA encoding for bone morphogenetic protein (BMP)-2 or -4 in alginate revealed that the formation of markers for osteogenesis and chondrogenic hypertrophy apparently depended on the BMP-transfection.	Alginates	175-183	bone morphogenetic protein 2	Mus musculus	131-165
12975360-11	2003	Data bank searches with the RepB primary structure yielded a 46.2% identity to the regulator of nucleoside diphosphate kinase, a formerly unknown protein from Escherichia coli that can restore a growth defect in alginate production in Pseudomonas aeruginosa.	Alginates	212-220	replication protein	Escherichia coli	28-32
12833588-6	2003	Integrin alpha5 and beta1 were strongly expressed in all groups, but integrin alpha1 was strongly expressed only in collagen type I and fibronectin conjugated alginate beads, and integrin alpha2 was strongly expressed only in collagen type II conjugated alginate beads.	Alginates	159-167	fibronectin 1	Homo sapiens	136-147
14517862-0	2003	Action of microparticles of heparin and alginate crosslinked gel when used as injectable artificial matrices to stabilize basic fibroblast growth factor and induce angiogenesis by controlling its release.	Alginates	40-48	fibroblast growth factor 2	Homo sapiens	122-152
14517862-2	2003	We developed a novel alginate gel sheet that is crosslinked with heparin (H/A gel sheet) and discovered its properties of releasing biologically active basic fibroblast growth factor (bFGF), a representative member of the heparin-binding growth factors (HBGFs), for about 1 month in vitro and of inducing angiogenesis in vivo.	Alginates	21-29	fibroblast growth factor 2	Homo sapiens	152-182
14517862-2	2003	We developed a novel alginate gel sheet that is crosslinked with heparin (H/A gel sheet) and discovered its properties of releasing biologically active basic fibroblast growth factor (bFGF), a representative member of the heparin-binding growth factors (HBGFs), for about 1 month in vitro and of inducing angiogenesis in vivo.	Alginates	21-29	fibroblast growth factor 2	Homo sapiens	184-188
12833588-6	2003	Integrin alpha5 and beta1 were strongly expressed in all groups, but integrin alpha1 was strongly expressed only in collagen type I and fibronectin conjugated alginate beads, and integrin alpha2 was strongly expressed only in collagen type II conjugated alginate beads.	Alginates	159-167	integrin subunit alpha 1	Homo sapiens	69-84
12909546-0	2003	Beneficial effects of human serum albumin on stability and functionality of alginate microcapsules fabricated in different ways.	Alginates	76-84	albumin	Rattus norvegicus	28-41
12919882-0	2003	Recombinant osteogenic protein-1 upregulates extracellular matrix metabolism by rabbit annulus fibrosus and nucleus pulposus cells cultured in alginate beads.	Alginates	143-151	bone morphogenetic protein 7	Homo sapiens	12-32
12919882-1	2003	This study was performed to determine if recombinant human osteogenic protein-1 (rhOP-1) is effective in promoting matrix synthesis and matrix formation by rabbit nucleus pulposus (NP) and annulus fibrosus (AF) cells cultured in alginate beads.	Alginates	229-237	bone morphogenetic protein 7	Homo sapiens	59-79
12885346-4	2003	These cells are protected from graft rejection in alginate microcapsules to function as "micro-organs" to deliver angiostatin in vivo.	Alginates	50-58	plasminogen	Mus musculus	114-125
12774179-7	2003	RT-PCR revealed that transcript levels of trout C/EBPbeta are clearly higher in sodium alginate-induced peritoneal cells than in head kidney and peritoneal cells of saline-injected fish or head kidney cells of alginate-injected fish.	Alginates	80-95	CCAAT enhancer binding protein beta	Homo sapiens	48-57
12774179-7	2003	RT-PCR revealed that transcript levels of trout C/EBPbeta are clearly higher in sodium alginate-induced peritoneal cells than in head kidney and peritoneal cells of saline-injected fish or head kidney cells of alginate-injected fish.	Alginates	87-95	CCAAT enhancer binding protein beta	Homo sapiens	48-57
12858460-11	2003	CONCLUSION: Prolonged IGF-I treatment of human OA chondrocytes in serum-free alginate cultures stimulated sulfate incorporation without significant accumulation of a proteoglycan matrix in longterm cultures.	Alginates	77-85	insulin like growth factor 1	Homo sapiens	22-27
12852588-0	2003	Suppression of leaf feeding and oviposition of phytophagous ladybird beetles (Coleoptera: Coccinellidae) by chitinase gene-transformed phylloplane bacteria and their specific bacteriophages entrapped in alginate gel beads.	Alginates	203-211	acidic 26 kDa endochitinase	Solanum lycopersicum	108-117
12761840-0	2003	Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres.	Alginates	58-66	fibroblast growth factor 2	Rattus norvegicus	113-143
12761840-2	2003	In the present article, we describe the construction of a novel porous alginate scaffold that incorporates tiny poly (lactic-co-glycolic acid) microspheres capable of controlling the release of angiogenic factors, such as basic fibroblast growth factor (bFGF).	Alginates	71-79	fibroblast growth factor 2	Rattus norvegicus	222-252
12761840-2	2003	In the present article, we describe the construction of a novel porous alginate scaffold that incorporates tiny poly (lactic-co-glycolic acid) microspheres capable of controlling the release of angiogenic factors, such as basic fibroblast growth factor (bFGF).	Alginates	71-79	fibroblast growth factor 2	Rattus norvegicus	254-258
12852588-1	2003	The chitinase gene-transformed strain KPM-007E/chi of Enterobacter cloacae was vitally entrapped in sodium alginate gel beads with its specific virulent bacteriophage EcP-01 to provide a new method for microbially digesting chitinous peritrophic membranes of phytophagous ladybird beetles Epilachna vigintioctopunctata.	Alginates	100-115	acidic 26 kDa endochitinase	Solanum lycopersicum	4-13
12852588-4	2003	KPM-007E/chi, entrapped in the alginate beads, released the chitinase.	Alginates	31-39	acidic 26 kDa endochitinase	Solanum lycopersicum	60-69
12881119-9	2003	Overall, the amount of free Ca2+ cross-linked with alginate in the formed microspheres was in the following order: calcium acetate &gt; calcium chloride + calcium acetate &gt; calcium chloride + calcium gluconate; calcium chloride + calcium lactate &gt; calcium chloride.	Alginates	51-59	carbonic anhydrase 2	Homo sapiens	28-31
12745082-3	2003	Here, we developed a novel APA microcapsule, in which APA microbeads (APA(Ba) microbeads) were modified to contain a barium alginate hydrogel within their centers in an attempt to make it more difficult for antibody and complement to permeate the microcapsules.	Alginates	117-132	glutamyl aminopeptidase	Mus musculus	27-30
12628829-11	2003	However, the release of low-molecular weight factors (such as insulin) may be delayed when using alginate concentrations in the usual range.	Alginates	97-105	insulin	Homo sapiens	62-69
12740084-0	2003	Addition of fibronectin to alginate matrix improves peripheral nerve regeneration in tissue-engineered conduits.	Alginates	27-35	fibronectin 1	Rattus norvegicus	12-23
12740084-8	2003	Addition of fibronectin to alginate hydrogel improved SC viability and growth profile in vitro.	Alginates	27-35	fibronectin 1	Rattus norvegicus	12-23
12740084-10	2003	The regeneration rate was enhanced when liquid fibronectin was added to the alginate matrix.	Alginates	76-84	fibronectin 1	Rattus norvegicus	47-58
12740084-12	2003	In conclusion, the addition of fibronectin to alginate hydrogel matrix contributed to improve nerve regeneration, supporting SC viability and augmenting their effect on axonal growth when transplanted in a bioengineered nerve conduit.	Alginates	46-54	fibronectin 1	Rattus norvegicus	31-42
12723939-0	2003	Modulation of TNF-alpha-induced ICAM-1 expression, NO and H2O2 production by alginate, allicin and ascorbic acid in human endothelial cells.	Alginates	77-85	tumor necrosis factor	Homo sapiens	14-23
12723939-0	2003	Modulation of TNF-alpha-induced ICAM-1 expression, NO and H2O2 production by alginate, allicin and ascorbic acid in human endothelial cells.	Alginates	77-85	intercellular adhesion molecule 1	Homo sapiens	32-38
12723939-4	2003	In addition, alginate, ascorbic acid and allicin were demonstrated to inhibit the TNF-alpha induced expression of ICAM-1 on the HUVECs in a dose-dependent manner.	Alginates	13-21	tumor necrosis factor	Homo sapiens	82-91
12723939-4	2003	In addition, alginate, ascorbic acid and allicin were demonstrated to inhibit the TNF-alpha induced expression of ICAM-1 on the HUVECs in a dose-dependent manner.	Alginates	13-21	intercellular adhesion molecule 1	Homo sapiens	114-120
12614083-6	2003	Alginate, a natural polymer recovered from seaweed is being developed as a nanoparticle for the delivery of insulin without being destroyed in the stomach.	Alginates	0-8	insulin	Homo sapiens	108-115
12579569-3	2003	It has been shown that enzymes known as C-5 epimerases convert M to G in the polymer chain, giving rise to novel alginates with tailored properties.	Alginates	113-122	complement C5	Homo sapiens	40-43
12579569-8	2003	The osmotic stability of alginate-poly-D-lysine(PDL)-alginate capsules was enhanced by the use of epimerized alginate; indeed, stable capsules with low permeability to tumor necrosis factor (TNF) could be made with low PDL exposures.	Alginates	25-33	tumor necrosis factor	Homo sapiens	168-189
12579569-8	2003	The osmotic stability of alginate-poly-D-lysine(PDL)-alginate capsules was enhanced by the use of epimerized alginate; indeed, stable capsules with low permeability to tumor necrosis factor (TNF) could be made with low PDL exposures.	Alginates	25-33	tumor necrosis factor	Homo sapiens	191-194
12579569-8	2003	The osmotic stability of alginate-poly-D-lysine(PDL)-alginate capsules was enhanced by the use of epimerized alginate; indeed, stable capsules with low permeability to tumor necrosis factor (TNF) could be made with low PDL exposures.	Alginates	53-61	tumor necrosis factor	Homo sapiens	191-194
12579569-8	2003	The osmotic stability of alginate-poly-D-lysine(PDL)-alginate capsules was enhanced by the use of epimerized alginate; indeed, stable capsules with low permeability to tumor necrosis factor (TNF) could be made with low PDL exposures.	Alginates	53-61	tumor necrosis factor	Homo sapiens	191-194
12554125-5	2003	Levels of MMP-2 were assessed by gelatin zymography following glucose deprivation of alginate cultures.	Alginates	85-93	matrix metallopeptidase 2	Homo sapiens	10-15
12554125-10	2003	Furthermore, secretion of MMP-2 was increased in alginate cultures deprived of glucose.	Alginates	49-57	matrix metallopeptidase 2	Homo sapiens	26-31
14983832-2	2003	Cobalt impregnated alginate beads are first formed by extrusion of an aqueous suspension of Co3O4 into a Co(II) chloride solution.	Alginates	19-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-111
14531571-4	2003	The aim of this project is to develop and implant genetically engineered producer cells secreting endostatin that are encapsulated in calcium cross-linked alginate gel beads.	Alginates	155-163	collagen type XVIII alpha 1 chain	Homo sapiens	98-108
14531571-8	2003	Alginate gel beads implanted into rat brain have shown only a moderate loss in cell viability but extended endostatin release for periods of up to 12 months.	Alginates	0-8	collagen type XVIII alpha 1 chain	Homo sapiens	107-117
12911123-0	2003	Evaluation of different types of alginate microcapsules as bioreactors for producing endostatin.	Alginates	33-41	collagen type XVIII alpha 1 chain	Homo sapiens	85-95
12614083-8	2003	Alginate has in addition, several other properties that have enabled it to be used as a matrix for entrapment and for the delivery of a variety of proteins such as insulin and cells.	Alginates	0-8	insulin	Homo sapiens	164-171
12911123-8	2003	Secretion of endostatin was detected in lower amounts from the enzymatically tailored alginate microcapsules compared with the native alginate microcapsules.	Alginates	86-94	collagen type XVIII alpha 1 chain	Homo sapiens	13-23
12499019-6	2003	We demonstrated the expression of spermatid-specific genes (protamine and transition protein 1) by alginate-encapsulate neonatal bull testis cells after 10 weeks in culture, suggesting that meiosis had occurred.	Alginates	99-107	transition protein 1	Homo sapiens	60-94
12911123-8	2003	Secretion of endostatin was detected in lower amounts from the enzymatically tailored alginate microcapsules compared with the native alginate microcapsules.	Alginates	134-142	collagen type XVIII alpha 1 chain	Homo sapiens	13-23
12396296-2	2002	This study describes the use of echo-planar magnetic resonance imaging (EPI) to visualise non-invasively intragastric alginate rafts of Liquid Gaviscon and Gaviscon Advance in healthy subjects.	Alginates	118-126	tissue factor pathway inhibitor	Homo sapiens	72-75
12469908-8	2002	In vitro, the Smads were also expressed and partly up-regulated by Il-1beta in alginate bead culture.	Alginates	79-87	interleukin 1 beta	Homo sapiens	67-75
12396296-10	2002	We conclude that EPI shows great potential in assessing alginate rafts formation in-vivo.	Alginates	56-64	tissue factor pathway inhibitor	Homo sapiens	17-20
12066877-0	2002	Encapsulation of insulin in chitosan-coated alginate beads: oral therapeutic peptide delivery.	Alginates	44-52	insulin	Homo sapiens	17-24
12102185-5	2002	The results of XPS, ATR-FTIR and contact angle confirmed that a stable thin film of alginate and its amino acid derivatives can be entrapped on the surface of PDL-LA membrane.	Alginates	84-92	ATR serine/threonine kinase	Homo sapiens	20-23
12066877-1	2002	Insulin was encapsulated in calcium alginate beads coated with chitosan.	Alginates	28-44	insulin	Homo sapiens	0-7
11523034-7	2001	Histological and immunohistochemical analysis of the TGF-beta 1-treated PLA/alginate amalgam and PLA constructs showed development of a cartilaginous phenotype from day 7 to day 21 as demonstrated by colocalization of Alcian blue staining with collagen type II and cartilage proteoglycan link protein.	Alginates	76-84	transforming growth factor beta 1	Homo sapiens	53-63
11916512-7	2002	These theoretical models for myoglobin facilitated oxygen transport with homogeneous Michaelis-Menten consumption also indicate that including myoglobin in the alginate gel would beneficially improve the flux of oxygen to the transplanted cells.	Alginates	160-168	myoglobin	Homo sapiens	29-38
11916512-7	2002	These theoretical models for myoglobin facilitated oxygen transport with homogeneous Michaelis-Menten consumption also indicate that including myoglobin in the alginate gel would beneficially improve the flux of oxygen to the transplanted cells.	Alginates	160-168	myoglobin	Homo sapiens	143-152
11853544-4	2002	Immortalized human articular chondrocytes, (tsT/AC62) cultured in monolayer after passage through alginate matrix (alg+) produced 5-fold greater amounts of PGE(2) than continuous monolayer cultures (alg-) after stimulation with IL-1beta.	Alginates	98-106	thiosulfate sulfurtransferase	Homo sapiens	44-47
11852701-6	2002	Of all the conjugates tested, basic fuchsin-modified alginate produced the greatest increase in the transfection of a plasmid coding for beta-galactosidase into HeLa cells.	Alginates	53-61	galactosidase beta 1	Homo sapiens	137-155
11927828-0	2002	Synthesis of a Kunitz-type serine proteinase inhibitory protein that shares homology with bovine pancreatic trypsin inhibitor by ovine intervertebral disc cells in serum-free alginate bead culture.	Alginates	175-183	spleen trypsin inhibitor I	Bos taurus	90-125
11950021-8	2002	A large amount (43%) of the IL-8 produced was stored in the alginate beads, whereas almost all IL-6 production (94%) was released in the culture supernatant.	Alginates	60-68	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
11880003-3	2002	Scanning electron microscopy was used for morphology observation, and elemental analysis was applied to determine the chitosan content bound on calcium-alginate gel beads (CAGB).	Alginates	144-160	S100 calcium binding protein A9	Homo sapiens	172-176
11772948-3	2002	We have entrapped these iNOS-expressing cells within a semipermeable alginate-poly-L-lysine membrane as a means of delivery to tumor sites in a nude mouse model.	Alginates	69-77	nitric oxide synthase 2, inducible	Mus musculus	24-28
12489186-1	2002	The objective of this study was to investigate the use of alginate hydrogels to present either exogenous or endogenous transforming growth factor (TGF)-beta 1 to the dentin-pulp complex to signal reparative processes.	Alginates	58-66	transforming growth factor beta 1	Homo sapiens	119-158
12489186-5	2002	Alginate hydrogels provide an appropriate matrix in which dental regeneration can take place and may also be useful for delivery of growth factors, including TGF-beta s, to enhance the natural regenerative capacity of the dental pulp.	Alginates	0-8	transforming growth factor beta 1	Homo sapiens	158-166
11811757-2	2002	For this purpose, an alginate microsystem, as a carrier of bovine serum albumin (BSA), as a model protein, was developed using a spray-drying technique.	Alginates	21-29	albumin	Homo sapiens	66-79
11745153-7	2001	In this case, insulin release was approximately 60% of that from intact bovine islets within sodium alginate microcapsules.	Alginates	93-108	insulin	Bos taurus	14-21
11748585-4	2001	Cells placed in a 3-dimensional matrix of alginate beads and cultured in a serum-free media with bone morphogenetic protein-2 and -9 induced expression of type II collagen (Col2A1) mRNA and increased expression of aggrecan and cartilage oligomeric matrix protein suggesting chondrogenic differentiation of the cells.	Alginates	42-50	collagen type II alpha 1 chain	Homo sapiens	173-179
11745155-4	2001	We propose a novel approach to the inhibition of angiogenesis by immobilizing VE-cadherin-secreting hybridoma cells in alginate-agarose microcapsules.	Alginates	119-127	cadherin 5	Mus musculus	78-89
11693551-4	2001	In the present study, we demonstrate that high mannuronic acid-containing alginate (HMA) inhibits gammaIR induced expression of ICAM-1, VCAM-1, and E-selectin on HUVEC in a dose dependent manner.	Alginates	74-82	intercellular adhesion molecule 1	Homo sapiens	128-134
11693551-4	2001	In the present study, we demonstrate that high mannuronic acid-containing alginate (HMA) inhibits gammaIR induced expression of ICAM-1, VCAM-1, and E-selectin on HUVEC in a dose dependent manner.	Alginates	74-82	vascular cell adhesion molecule 1	Homo sapiens	136-142
11693551-4	2001	In the present study, we demonstrate that high mannuronic acid-containing alginate (HMA) inhibits gammaIR induced expression of ICAM-1, VCAM-1, and E-selectin on HUVEC in a dose dependent manner.	Alginates	74-82	selectin E	Homo sapiens	148-158
11683174-3	2001	Administration of exogenous LIF by slow release alginate gels in vivo sustained the level of myoblast proliferation at 2 days in regenerating crush-injured muscle.	Alginates	48-56	LIF interleukin 6 family cytokine	Homo sapiens	28-31
11510552-1	2001	Use of alginate as a free bioligand incorporated in an aqueous two-phase system of polyethylene glycol 6000-salt resulted in considerable purification of wheat germ alpha-amylase and sweet potato beta-amylase from their crude extracts.	Alginates	7-15	beta-amylase	Triticum aestivum	196-208
11559558-0	2001	Intravital microscopy reveals novel antivascular and antitumor effects of endostatin delivered locally by alginate-encapsulated cells.	Alginates	106-114	collagen type XVIII alpha 1 chain	Homo sapiens	74-84
11485547-8	2001	We maintained cells for up to 28 weeks in an alginate bead system, which prevented dedifferentiation and led to a stabilization of collagen and COMP expression.	Alginates	45-53	cartilage oligomeric matrix protein	Bos taurus	144-148
11697718-6	2001	The effects of an encapsulated TRAP in composite poly(N-vinyl caprolactam)-calcium alginate (PVCL) hydrogel films were investigated in a mouse model of wound healing.	Alginates	75-91	signal sequence receptor, delta	Mus musculus	31-35
11516252-0	2001	Microvascularization and ventricular function after local alginate-encapsulated angiogenic growth factor treatment in a rat cryothermia-induced myocardial infarction model.	Alginates	58-66	myotrophin	Rattus norvegicus	91-104
11340591-0	2001	Sustained release of basic fibroblast growth factor and angiogenesis in a novel covalently crosslinked gel of heparin and alginate.	Alginates	122-130	fibroblast growth factor 2	Rattus norvegicus	21-51
11448046-2	2001	For these requirements, a microsystem based on cross-linked alginate as the carrier of bovine serum albumin (BSA), used as a model protein, was proposed.	Alginates	60-68	albumin	Homo sapiens	94-107
11426874-1	2001	In 1980, Lim and Sun introduced a microcapsule coated with an alginate/polylysine complex for encapsulation of pancreatic islets.	Alginates	62-70	PDZ and LIM domain 5	Homo sapiens	9-12
11493277-4	2001	The objective of this study was to determine the in vitro release behavior of VEGF from calcium alginate microspheres and the potency of this controlled release system in promoting localized neovascularization at the subcutaneous site of the rat model.	Alginates	88-104	vascular endothelial growth factor A	Rattus norvegicus	78-82
11451494-4	2001	Human Serum Albumin (HSA), used as a model protein, was efficiently entrapped within the alginate microcores using a high-speed stirrer and then microencapsulated into PELA copolymer using a w/o/w solvent extraction method.	Alginates	89-97	albumin	Homo sapiens	6-19
11435959-7	2001	The culture of NPCCs immobilized in alginate resulted with 3-fold increase in insulin content and 9-fold increase in insulin/DNA ratio.	Alginates	36-44	insulin	Homo sapiens	78-85
11435959-7	2001	The culture of NPCCs immobilized in alginate resulted with 3-fold increase in insulin content and 9-fold increase in insulin/DNA ratio.	Alginates	36-44	insulin	Homo sapiens	117-124
28866941-11	2001	By combining soluble PLL and alginate both the toxic and TNF-inducing effects of PLL were reduced.	Alginates	29-37	tumor necrosis factor	Homo sapiens	57-60
11448107-0	2001	Regulation of gelatinase-A (MMP-2) production by ovine intervertebral disc nucleus pulposus cells grown in alginate bead culture by Transforming Growth Factor-beta(1)and insulin like growth factor-I.	Alginates	107-115	matrix metallopeptidase 2	Homo sapiens	28-33
11299077-10	2001	These results show that SA has a strong hypocholesterolaemic effect in rats which is similar to that of GG, and that this effect is most likely to be mediated through an interruption in the entero-hepatic circulation of bile acids and not through increased hepatic supply of propionate from fermentation of the NSP in the large bowel.	Alginates	24-26	reticulon 1	Rattus norvegicus	311-314
11162592-6	2001	As a well-known fact, cultures in alginate in medium where FCS was replaced by IGF1 and TGF beta 2 results in increased collagen type II formation, indicative for redifferentiation.	Alginates	34-42	insulin like growth factor 1	Homo sapiens	79-83
11162592-6	2001	As a well-known fact, cultures in alginate in medium where FCS was replaced by IGF1 and TGF beta 2 results in increased collagen type II formation, indicative for redifferentiation.	Alginates	34-42	transforming growth factor beta 2	Homo sapiens	88-98
11218383-12	2001	5) From the above, in the alginate immunized group, the scavenging function of neutrophils for the alg-IC deposited in lung tissue would be suppressed resulting from the decrease in CD16/32 positive neutrophils, in spite of the increase in total count of neutrophils.	Alginates	26-34	Fc receptor, IgG, low affinity III	Mus musculus	182-186
11437072-11	2001	By combining soluble PLL and alginate both the toxic and TNF-inducing effects of PLL were reduced.	Alginates	29-37	tumor necrosis factor	Homo sapiens	57-60
10906670-0	2000	Time course of transforming growth factor-beta(1) (TGF-beta(1)) mRNA expression in the host reaction to alginate-poly-L-lysine microcapsules following implantations into rat epididymal fat pads.	Alginates	104-112	transforming growth factor, beta 1	Rattus norvegicus	15-49
11054748-3	2000	Furthermore, we developed a controlled release device for LIF based on a calcium alginate rod (release rate about 0.5% per day).	Alginates	73-89	leukemia inhibitory factor	Mus musculus	58-61
11044913-5	2000	Using this strategy, we injected beta-glucuronidase-secreting fibroblasts enclosed in alginate microcapsules into mutant MPS VII mice.	Alginates	86-94	glucuronidase, beta	Mus musculus	33-51
11037878-10	2000	The levels of COL2A1 and aggrecan mRNA were increased after transfer from monolayer to alginate culture at 32 degrees C. Treatment with IL-1beta decreased COL2A1 and aggrecan mRNA levels and increased the levels of matrix metalloproteinases 1, 3, and 13 mRNA, as well as those of cyclooxygenase 2, type I collagen, and secretory phospholipase A2 type IIA mRNA, but not those of inducible nitric oxide synthase mRNA.	Alginates	87-95	collagen type II alpha 1 chain	Homo sapiens	14-20
11037878-10	2000	The levels of COL2A1 and aggrecan mRNA were increased after transfer from monolayer to alginate culture at 32 degrees C. Treatment with IL-1beta decreased COL2A1 and aggrecan mRNA levels and increased the levels of matrix metalloproteinases 1, 3, and 13 mRNA, as well as those of cyclooxygenase 2, type I collagen, and secretory phospholipase A2 type IIA mRNA, but not those of inducible nitric oxide synthase mRNA.	Alginates	87-95	interleukin 1 beta	Homo sapiens	136-144
11037878-13	2000	CONCLUSION: The tsT/AC62 cells provide a reproducible model that mimics the adult articular chondrocyte phenotype, particularly in alginate culture, and demonstrates characteristic responses to IL-1beta.	Alginates	131-139	thiosulfate sulfurtransferase	Homo sapiens	16-19
10906670-0	2000	Time course of transforming growth factor-beta(1) (TGF-beta(1)) mRNA expression in the host reaction to alginate-poly-L-lysine microcapsules following implantations into rat epididymal fat pads.	Alginates	104-112	transforming growth factor, beta 1	Rattus norvegicus	51-62
10938736-8	2000	Both SA-elicited and SG-elicited PC expressed higher amounts of IL-1 beta and SAA mRNA compared to saline-injected fish HKC and PC, indicating that these proteins are associated with inflammatory responses, similar to mammalian homologues.	Alginates	5-7	interleukin 1 beta	Homo sapiens	64-73
11174072-1	2000	OBJECTIVE: To analyze the gene expression of osteoarthritic chondrocytes cultured in alginate after stimulation with interleukin (IL)-1beta.	Alginates	85-93	interleukin 1 beta	Homo sapiens	117-139
11014363-5	2000	Isolated chondrocytes were cultured in alginate in serum-free medium and stimulated with IGF-1 or des(1-3) IGF-1, which has a much lower affinity for IGF binding proteins (IGFBP) than IGF-1.	Alginates	39-47	insulin like growth factor 1	Homo sapiens	107-112
11014363-5	2000	Isolated chondrocytes were cultured in alginate in serum-free medium and stimulated with IGF-1 or des(1-3) IGF-1, which has a much lower affinity for IGF binding proteins (IGFBP) than IGF-1.	Alginates	39-47	insulin like growth factor 1	Homo sapiens	107-112
10737883-0	2000	Alginate hydrogel linked with synthetic oligopeptide derived from BMP-2 allows ectopic osteoinduction in vivo.	Alginates	0-8	bone morphogenetic protein 2	Rattus norvegicus	66-71
10737883-4	2000	In this study, a novel BMP-2-derived oligopeptide, NSVNSKIPKACCVPTELSAI, was coupled covalently to alginate.	Alginates	99-107	bone morphogenetic protein 2	Rattus norvegicus	23-28
10737883-6	2000	Ectopic bone formation was observed in alginate hydrogel linked with BMP-2-derived peptide.	Alginates	39-47	bone morphogenetic protein 2	Rattus norvegicus	69-74
10737883-7	2000	It is suggested that alginate hydrogel linked with an oligopeptide derived from BMP-2 might provide an alternative system for topical delivery of the morphogenetic signal of BMP-2.	Alginates	21-29	bone morphogenetic protein 2	Rattus norvegicus	80-85
10737883-7	2000	It is suggested that alginate hydrogel linked with an oligopeptide derived from BMP-2 might provide an alternative system for topical delivery of the morphogenetic signal of BMP-2.	Alginates	21-29	bone morphogenetic protein 2	Rattus norvegicus	174-179
10938736-8	2000	Both SA-elicited and SG-elicited PC expressed higher amounts of IL-1 beta and SAA mRNA compared to saline-injected fish HKC and PC, indicating that these proteins are associated with inflammatory responses, similar to mammalian homologues.	Alginates	5-7	serum amyloid A1 cluster	Homo sapiens	78-81
11810531-11	2000	When environmental conditions for bacteria deteriorate, GMD enzyme is activated, production of alginate is initiated, and then biofilm is formed.	Alginates	95-103	GDP-mannose 4,6-dehydratase	Pseudomonas aeruginosa PAO1	56-59
10668387-5	1999	Immunoisolation of insulin-producing graft in alginate capsules protects the transplant from immunological damage.	Alginates	46-54	insulin	Homo sapiens	19-26
10737549-8	2000	Among polysaccharides tested, only the highly viscous alginates could affect intestinal absorption of glucose and insulin response.	Alginates	54-63	insulin	Sus scrofa	114-121
10516587-1	1999	The diffusivity of a protein solute (bovine serum albumin) within calcium alginate gels made from sodium alginate of different guluronic acid content was determined.	Alginates	66-82	albumin	Homo sapiens	44-57
10644316-8	2000	Luminal administration of sodium alginate (an algal polysaccharide used as a food additive) or ulvan (a sulphated algal polymer) induced a dose dependent increase in mucin discharge over the concentration range 1-25 mg/l (p&lt;0.05 for 25 mg/l alginate and p&lt;0.05 for 10 and 25 mg/l ulvan).	Alginates	26-41	solute carrier family 13 member 2	Rattus norvegicus	166-171
10644316-8	2000	Luminal administration of sodium alginate (an algal polysaccharide used as a food additive) or ulvan (a sulphated algal polymer) induced a dose dependent increase in mucin discharge over the concentration range 1-25 mg/l (p&lt;0.05 for 25 mg/l alginate and p&lt;0.05 for 10 and 25 mg/l ulvan).	Alginates	33-41	solute carrier family 13 member 2	Rattus norvegicus	166-171
10644316-15	2000	CONCLUSIONS: Two algal polysaccharides (alginate and ulvan), two uronic acids (glucuronic acid and galacturonic acid), and the short chain fatty acids acetate and butyrate induce mucin secretion in rat colon.	Alginates	40-48	solute carrier family 13 member 2	Rattus norvegicus	179-184
10377143-2	1999	Mucosal as well as systemic antibody responses to PS were evoked by peroral or intranasal immunization of BALB/c mice with PS-cholera toxin B subunit (CTB) conjugates entrapped in the alginate microspheres (AM).	Alginates	184-192	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	123-149
10535819-0	1999	Serum albumin-alginate coated beads: mechanical properties and stability.	Alginates	14-22	albumin	Homo sapiens	0-13
10535819-1	1999	According to a previously described method, alginate beads were prepared from a Na-alginate solution containing propylene glycol alginate (PGA) and human serum albumin (HSA).	Alginates	44-52	albumin	Homo sapiens	154-167
10496900-1	1999	We demonstrate that a mucoid, alginate-producing strain of Pseudomonas aeruginosa isolated from the lungs of a cystic fibrosis (CF) patient secretes multiple enzymes with nucleoside diphosphate kinase (Ndk), ATPase, adenylate kinase, 5"-nucleotidase, and ATP-modifying enzymatic activities.	Alginates	30-38	cytidine/uridine monophosphate kinase 2	Homo sapiens	171-200
10496900-1	1999	We demonstrate that a mucoid, alginate-producing strain of Pseudomonas aeruginosa isolated from the lungs of a cystic fibrosis (CF) patient secretes multiple enzymes with nucleoside diphosphate kinase (Ndk), ATPase, adenylate kinase, 5"-nucleotidase, and ATP-modifying enzymatic activities.	Alginates	30-38	cytidine/uridine monophosphate kinase 2	Homo sapiens	202-205
10496900-1	1999	We demonstrate that a mucoid, alginate-producing strain of Pseudomonas aeruginosa isolated from the lungs of a cystic fibrosis (CF) patient secretes multiple enzymes with nucleoside diphosphate kinase (Ndk), ATPase, adenylate kinase, 5"-nucleotidase, and ATP-modifying enzymatic activities.	Alginates	30-38	dynein axonemal heavy chain 8	Homo sapiens	208-214
10383954-14	1999	On a solid medium, the FRD1 rpoS mutant produced approximately 70% less alginate than did the wild-type strain.	Alginates	72-80	RNA polymerase sigma factor RpoS	Pseudomonas aeruginosa PAO1	28-32
10545430-2	1999	METHODS AND RESULTS: We conducted a randomized, double-blind, placebo-controlled study of basic fibroblast growth factor (bFGF; 10 or 100 microg versus placebo) delivered via sustained-release heparin-alginate microcapsules implanted in ischemic and viable but ungraftable myocardial territories in patients undergoing CABG.	Alginates	201-209	fibroblast growth factor 2	Homo sapiens	90-120
10458407-3	1999	MATERIALS AND METHODS: A time release method of delivery was developed using sodium alginate microspheres containing recombinant human (rh) TGF-beta1.	Alginates	77-92	transforming growth factor beta 1	Homo sapiens	140-149
10458407-7	1999	RESULTS: Alginate microspheres containing [125I]-rh-TGF-beta1 showed slow-release kinetics (t1/2 = 10.5 hours).	Alginates	9-17	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	52-61
10458407-11	1999	Injection of rh-TGF-beta1 impregnated alginate microspheres into the corpus cavernosum resulted in dose-dependent decreases in percentage of corporal smooth muscle.	Alginates	38-46	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	16-25
10377143-2	1999	Mucosal as well as systemic antibody responses to PS were evoked by peroral or intranasal immunization of BALB/c mice with PS-cholera toxin B subunit (CTB) conjugates entrapped in the alginate microspheres (AM).	Alginates	184-192	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	151-154
9930964-5	1999	In one study, insulin independence was achieved in spontaneously diabetic dogs by islet microencapsulation inside uncoated alginate gel spheres (Mr exclusion &gt;600 kD).	Alginates	123-131	insulin	Canis lupus familiaris	14-21
10213255-6	1999	Purified Pseudomonas aeruginosa alginate stimulated mucin and lysozyme secretion in a dose-dependent fashion (mucin = +111%: P = 0.003; lysozyme = +20%: P = 0.024 at 200 microg/mL).	Alginates	32-40	lysozyme C	Mustela putorius furo	62-70
10213255-6	1999	Purified Pseudomonas aeruginosa alginate stimulated mucin and lysozyme secretion in a dose-dependent fashion (mucin = +111%: P = 0.003; lysozyme = +20%: P = 0.024 at 200 microg/mL).	Alginates	32-40	lysozyme C	Mustela putorius furo	136-144
10194843-13	1999	Orally administered alginate microspheres containing antigen have successfully induced immunity in mice to enteric (rotavirus) pathogens and in the respiratory tract in cattle with a model antigen (ovalbumin).	Alginates	20-28	ovalbumin	Bos taurus	198-207
10220287-0	1999	Prolongation of the effective duration of cytomedical therapy by re-injecting SK2 hybridoma cells microencapsulated within alginate-poly(L)lysine-alginate membranes into human interleukin-6 transgenic mice.	Alginates	123-131	sphingosine kinase 2	Homo sapiens	78-81
10220287-1	1999	We previously reported that SK2 hybridoma cells that secreted anti-human interleukin-6 (hIL-6) monoclonal antibodies (SK2 mAb) were microencapsulated within alginate-poly(L)lysine-alginate (APA) membranes (APA-SK2 cells) for immunoisolation, and a single intraperitoneal injection of these APA-SK2 cells remarkably improved IgG1 plasmacytosis in hIL-6 transgenic mice (hIL-6 Tgm).	Alginates	157-165	skin antigen 2	Mus musculus	28-31
10220287-1	1999	We previously reported that SK2 hybridoma cells that secreted anti-human interleukin-6 (hIL-6) monoclonal antibodies (SK2 mAb) were microencapsulated within alginate-poly(L)lysine-alginate (APA) membranes (APA-SK2 cells) for immunoisolation, and a single intraperitoneal injection of these APA-SK2 cells remarkably improved IgG1 plasmacytosis in hIL-6 transgenic mice (hIL-6 Tgm).	Alginates	157-165	interleukin 6	Mus musculus	73-86
10220287-1	1999	We previously reported that SK2 hybridoma cells that secreted anti-human interleukin-6 (hIL-6) monoclonal antibodies (SK2 mAb) were microencapsulated within alginate-poly(L)lysine-alginate (APA) membranes (APA-SK2 cells) for immunoisolation, and a single intraperitoneal injection of these APA-SK2 cells remarkably improved IgG1 plasmacytosis in hIL-6 transgenic mice (hIL-6 Tgm).	Alginates	157-165	interleukin 6	Homo sapiens	88-93
10220287-1	1999	We previously reported that SK2 hybridoma cells that secreted anti-human interleukin-6 (hIL-6) monoclonal antibodies (SK2 mAb) were microencapsulated within alginate-poly(L)lysine-alginate (APA) membranes (APA-SK2 cells) for immunoisolation, and a single intraperitoneal injection of these APA-SK2 cells remarkably improved IgG1 plasmacytosis in hIL-6 transgenic mice (hIL-6 Tgm).	Alginates	157-165	skin antigen 2	Mus musculus	118-121
10220287-1	1999	We previously reported that SK2 hybridoma cells that secreted anti-human interleukin-6 (hIL-6) monoclonal antibodies (SK2 mAb) were microencapsulated within alginate-poly(L)lysine-alginate (APA) membranes (APA-SK2 cells) for immunoisolation, and a single intraperitoneal injection of these APA-SK2 cells remarkably improved IgG1 plasmacytosis in hIL-6 transgenic mice (hIL-6 Tgm).	Alginates	157-165	skin antigen 2	Mus musculus	118-121
10220287-1	1999	We previously reported that SK2 hybridoma cells that secreted anti-human interleukin-6 (hIL-6) monoclonal antibodies (SK2 mAb) were microencapsulated within alginate-poly(L)lysine-alginate (APA) membranes (APA-SK2 cells) for immunoisolation, and a single intraperitoneal injection of these APA-SK2 cells remarkably improved IgG1 plasmacytosis in hIL-6 transgenic mice (hIL-6 Tgm).	Alginates	157-165	skin antigen 2	Mus musculus	118-121
10837701-6	1999	Our objective was to test the therapeutic effectiveness of alginate-polylysine microcapsules for the transplantation of human-insulin-producing cells into a human diabetic patient, a 38-year-old white male with insulin-dependent diabetes for 30 years.	Alginates	59-67	insulin	Homo sapiens	126-133
10022530-3	1999	Alginate-poly-L-lysine-alginate microcapsules enclosing mouse C2C12 myoblasts expressing the marker gene human growth hormone (hGH) at 95+/-20 ng/million cells/hr were implanted into the right lateral ventricles of mice under stereotaxic guidance.	Alginates	0-8	growth hormone 1	Homo sapiens	111-125
9811480-5	1998	Alginate/heparin-Sepharose microspheres and films were designed as drug carriers to control release the bFGF-SAP conjugate or bFGF alone in small doses.	Alginates	0-8	fibroblast growth factor 2	Bos taurus	104-108
9811480-5	1998	Alginate/heparin-Sepharose microspheres and films were designed as drug carriers to control release the bFGF-SAP conjugate or bFGF alone in small doses.	Alginates	0-8	fibroblast growth factor 2	Bos taurus	126-130
9877401-7	1998	In alginate cultures, fibronectin alone stimulated the incorporation of [35S].	Alginates	3-11	fibronectin 1	Homo sapiens	22-33
9877401-8	1998	Fibronectin with 10 ng/ml insulin-like growth factor-I had additive effects in alginate culture, producing the maximum incorporation of [35S].	Alginates	79-87	fibronectin 1	Rattus norvegicus	0-11
9877401-8	1998	Fibronectin with 10 ng/ml insulin-like growth factor-I had additive effects in alginate culture, producing the maximum incorporation of [35S].	Alginates	79-87	insulin like growth factor 1	Homo sapiens	26-54
9877401-11	1998	Thus, fibronectin enhanced proteoglycan synthesis and the response to insulin-like growth factor-I in alginate but inhibited the response to the growth factor in monolayers.	Alginates	102-110	fibronectin 1	Homo sapiens	6-17
9877401-11	1998	Thus, fibronectin enhanced proteoglycan synthesis and the response to insulin-like growth factor-I in alginate but inhibited the response to the growth factor in monolayers.	Alginates	102-110	insulin like growth factor 1	Homo sapiens	70-98
9711803-3	1998	Functional depletion of CD4+ and CD8+ and IFN gamma was obtained in vivo by intraperitoneal injection of alginate-encapsulated anti-CD4, -CD8 or -IFN gamma producing hybridoma"s before and at the moment of vaccination.	Alginates	105-113	CD4 antigen	Mus musculus	24-27
9711803-3	1998	Functional depletion of CD4+ and CD8+ and IFN gamma was obtained in vivo by intraperitoneal injection of alginate-encapsulated anti-CD4, -CD8 or -IFN gamma producing hybridoma"s before and at the moment of vaccination.	Alginates	105-113	interferon gamma	Mus musculus	42-51
9711803-3	1998	Functional depletion of CD4+ and CD8+ and IFN gamma was obtained in vivo by intraperitoneal injection of alginate-encapsulated anti-CD4, -CD8 or -IFN gamma producing hybridoma"s before and at the moment of vaccination.	Alginates	105-113	CD4 antigen	Mus musculus	132-135
9711803-3	1998	Functional depletion of CD4+ and CD8+ and IFN gamma was obtained in vivo by intraperitoneal injection of alginate-encapsulated anti-CD4, -CD8 or -IFN gamma producing hybridoma"s before and at the moment of vaccination.	Alginates	105-113	interferon gamma	Mus musculus	146-155
9759927-6	1998	Encapsulation of the pGH-PFF with an alginate-poly-L-lysine-alginate membrane did not show any deterioration in their proliferation and survival both in vitro and in vivo.	Alginates	37-45	somatotropin	Sus scrofa	21-24
9648917-0	1998	Dedifferentiated chondrocytes cultured in alginate beads: restoration of the differentiated phenotype and of the metabolic responses to interleukin-1beta.	Alginates	42-50	interleukin 1 beta	Homo sapiens	136-153
10197168-0	1998	Matrix degradation by chondrocytes cultured in alginate: IL-1 beta induces proteoglycan degradation and proMMP synthesis but does not result in collagen degradation.	Alginates	47-55	interleukin 1 beta	Homo sapiens	57-66
9648917-7	1998	Compared with cells in primary culture, the production of nitric oxide and 92-kDa gelatinase in response to interleukin-1beta was impaired in cells at passage 2 in monolayer but was fully recovered after their culture in alginate beads for 2 weeks.	Alginates	221-229	interleukin 1 beta	Homo sapiens	108-125
9648917-9	1998	This makes the culture in alginate beads a relevant model for the study of chondrocyte biology in the presence of interleukin-1beta and other mediators of cartilage destruction in rheumatoid arthritis and osteoarthrosis.	Alginates	26-34	interleukin 1 beta	Homo sapiens	114-131
9682785-18	1998	CONCLUSIONS: This study demonstrates that both IGF-1 and TGF beta-2 significantly but differently influence proteoglycan synthesis and accumulation in the cell-associated matrix compartment of cultured bovine chondrocytes in alginate.	Alginates	225-233	insulin like growth factor 1	Bos taurus	47-52
9689917-4	1998	TGF-beta 1 increased aggrecan mRNA in both systems, whereas biglycan message was elevated only in alginate.	Alginates	98-106	biglycan	Oryctolagus cuniculus	60-68
9689917-9	1998	Passaged chondrocytes transferred to alginate re-expressed high levels of aggrecan, decorin and biglycan.	Alginates	37-45	decorin	Oryctolagus cuniculus	84-91
9689917-9	1998	Passaged chondrocytes transferred to alginate re-expressed high levels of aggrecan, decorin and biglycan.	Alginates	37-45	biglycan	Oryctolagus cuniculus	96-104
9682785-18	1998	CONCLUSIONS: This study demonstrates that both IGF-1 and TGF beta-2 significantly but differently influence proteoglycan synthesis and accumulation in the cell-associated matrix compartment of cultured bovine chondrocytes in alginate.	Alginates	225-233	transforming growth factor beta 2	Bos taurus	57-67
9682785-20	1998	However, addition of TGF beta-2 to bovine articular chondrocytes cultured in alginate beads for 13 days results in a significant reduction of the relative volume of the pericellular matrix compartment compared to controls, indicating differences in assembly of the matrix.	Alginates	77-85	transforming growth factor beta 2	Bos taurus	21-31
9741929-5	1998	The loading content of PS19-CTB to the alginate microspheres was 60%.	Alginates	39-47	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	23-31
9741929-9	1998	Peroral immunization with 25 microg of PS19-CTB entrapped in the alginate microspheres evoked both the mucosal IgA and systemic IgM responses to PS19 in small intestine and in sera, respectively.	Alginates	65-73	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	39-47
9741929-10	1998	The results suggest that both the mucosal and systemic antibody responses could be induced by oral administration of the PS19-CTB antigen entrapped in alginate microspheres.	Alginates	151-159	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	121-129
9860169-0	1998	Release from alginate enhances the biological activity of vascular endothelial growth factor.	Alginates	13-21	vascular endothelial growth factor A	Homo sapiens	58-92
9621568-13	1998	But in alginate group they were temporally decreased on day 2, and they were gradually increased (MPO: 99.7 +/- 16.5--&gt;212.6 +/- 12.1: p &lt; 0.001, TNF alpha: 59.2 +/- 13.3--&gt;162.4 +/- 30.9: p &lt; 0.01).	Alginates	7-15	myeloperoxidase	Mus musculus	98-101
9621568-13	1998	But in alginate group they were temporally decreased on day 2, and they were gradually increased (MPO: 99.7 +/- 16.5--&gt;212.6 +/- 12.1: p &lt; 0.001, TNF alpha: 59.2 +/- 13.3--&gt;162.4 +/- 30.9: p &lt; 0.01).	Alginates	7-15	tumor necrosis factor	Mus musculus	152-161
9621568-14	1998	The temporally decrease of MPO and TNF alpha on day 2 in alginate group may suggest that a large amount of alginate inhibits neutrophils chemotaxis.	Alginates	57-65	myeloperoxidase	Mus musculus	27-30
9621568-14	1998	The temporally decrease of MPO and TNF alpha on day 2 in alginate group may suggest that a large amount of alginate inhibits neutrophils chemotaxis.	Alginates	57-65	tumor necrosis factor	Mus musculus	35-44
9621568-14	1998	The temporally decrease of MPO and TNF alpha on day 2 in alginate group may suggest that a large amount of alginate inhibits neutrophils chemotaxis.	Alginates	107-115	myeloperoxidase	Mus musculus	27-30
9621568-14	1998	The temporally decrease of MPO and TNF alpha on day 2 in alginate group may suggest that a large amount of alginate inhibits neutrophils chemotaxis.	Alginates	107-115	tumor necrosis factor	Mus musculus	35-44
9621568-16	1998	In alginate group, MFI of IFN gamma in BALF was increased on day 5 (110.0 +/- 32.9--&gt;201.0 +/- 49.3: p &lt; 0.001) and kept a high level till day 30 (223.0 +/- 57.5: p &lt; 0.01).	Alginates	3-11	interferon gamma	Mus musculus	26-35
9621568-20	1998	Inferences are drawn from the clinical results and the experimental ones that the CD3 positive IFN gamma lymphocytes expressed by immunological interaction with mucoid-alginate and the IFN gamma lymphocytes (Th1 like cells) plays an important role on advancement of chronic airway infection with mucoid P. aeruginosa.	Alginates	168-176	CD3 antigen, epsilon polypeptide	Mus musculus	82-85
9621568-20	1998	Inferences are drawn from the clinical results and the experimental ones that the CD3 positive IFN gamma lymphocytes expressed by immunological interaction with mucoid-alginate and the IFN gamma lymphocytes (Th1 like cells) plays an important role on advancement of chronic airway infection with mucoid P. aeruginosa.	Alginates	168-176	interferon gamma	Mus musculus	95-104
9472779-4	1998	Canine MDCK cells encapsulated in alginate microcapsules were able to deliver recombinant human growth hormone to nonautologous dogs in vivo.	Alginates	34-42	growth hormone 1	Homo sapiens	96-110
9472779-7	1998	Laminating the surface of the beads with poly-L-lysine and alginate provided an even more mechanically stable device that lasted for &gt;2 months instead of &lt;14 days in vivo and delivered &gt;20 ng of human growth hormone/ml of plasma within the first week.	Alginates	59-67	growth hormone 1	Homo sapiens	210-224
9541461-0	1998	Induction of pulmonary immunity in cattle by oral administration of ovalbumin in alginate microspheres.	Alginates	81-89	ovalbumin	Bos taurus	68-77
9541461-4	1998	The purpose of this study was to determine whether the oral administration of a model antigen (ovalbumin) in alginate microspheres could induce pulmonary immunity in cattle.	Alginates	109-117	ovalbumin	Bos taurus	95-104
9860169-5	1998	Spherical alginate beads (3.3+/-0.1 mm diameter) were examined as a means of delivering biologically functional VEGF at a controlled rate over extended times.	Alginates	10-18	vascular endothelial growth factor A	Homo sapiens	112-116
9860169-6	1998	The alginate beads demonstrated the ability to incorporate VEGF with an efficiency between 30 and 67%, depending on the processing conditions, and release it at a constant rate (5%/day) for up to 14 days in vitro.	Alginates	4-12	vascular endothelial growth factor A	Homo sapiens	59-63
9860169-8	1998	The release kinetics of freeze dried VEGF containing alginate beads were also examined and found to be comparable to non-freeze dried samples.	Alginates	53-61	vascular endothelial growth factor A	Homo sapiens	37-41
9616735-5	1997	Recombinant gene products with potential therapeutic applications (human growth hormone, factor IX, lysosomal enzymes, adenosine deaminase) have been expressed from genetically modified cells after encapsulation with alginate-poly-L-lysine-alginate or hydroxyethyl methacrylate-methyl methacrylate.	Alginates	217-225	adenosine deaminase	Homo sapiens	119-138
9616735-7	1997	After intraperitoneal implantation, genetically modified mouse Ltk- fibroblasts or C2C12 myoblasts encapsulated in alginate-poly-L-lysine-alginate could deliver recombinant gene products (human growth hormone, human factor IX) to the systemic circulation of mice.	Alginates	115-123	growth hormone 1	Homo sapiens	194-208
9387225-0	1997	Pseudomonas aeruginosa in cystic fibrosis: role of mucC in the regulation of alginate production and stress sensitivity.	Alginates	77-85	positive regulator for alginate biosynthesis MucC	Pseudomonas aeruginosa PAO1	51-55
9393554-3	1997	An animal model of this infection was established in two strains of mice: C3H/HeN and BALB/c, generally known as Th1 and Th2 responders, respectively, which were challenged with alginate-embedded P. aeruginosa.	Alginates	178-186	negative elongation factor complex member C/D, Th1l	Mus musculus	113-116
9387225-10	1997	These findings support a negative regulatory role of mucC in alginate production by P. aeruginosa, indicate additive effects of muc genes in the regulation of mucoidy in this organism and suggest that multiple stress signals and recognition systems participate in the regulation of algU-dependent functions.	Alginates	61-69	positive regulator for alginate biosynthesis MucC	Pseudomonas aeruginosa PAO1	53-57
9061040-0	1997	Cytomedical therapy for IgG1 plasmacytosis in human interleukin-6 transgenic mice using hybridoma cells microencapsulated in alginate-poly(L)lysine-alginate membrane.	Alginates	125-133	LOC105243590	Mus musculus	24-28
9331506-7	1997	Alginate appeared to prevent the secretion, because ACTH levels decreased in alginate-suspended cells after day 14.	Alginates	0-8	pro-opiomelanocortin-alpha	Mus musculus	52-56
9331506-7	1997	Alginate appeared to prevent the secretion, because ACTH levels decreased in alginate-suspended cells after day 14.	Alginates	77-85	pro-opiomelanocortin-alpha	Mus musculus	52-56
9061040-1	1997	Cytomedical therapy for human interleukin-6 transgenic mice (hIL-6 Tgm) was implemented by the intraperitoneal injection of alginate-poly(L)lysine-alginate (APA) membranes microencapsulating SK2 hybridoma cells (APA-SK2 cells) which secrete anti-hIL-6 monoclonal antibodies (SK2 mAb).	Alginates	124-132	interleukin 6	Homo sapiens	30-43
9061040-1	1997	Cytomedical therapy for human interleukin-6 transgenic mice (hIL-6 Tgm) was implemented by the intraperitoneal injection of alginate-poly(L)lysine-alginate (APA) membranes microencapsulating SK2 hybridoma cells (APA-SK2 cells) which secrete anti-hIL-6 monoclonal antibodies (SK2 mAb).	Alginates	124-132	interleukin 6	Homo sapiens	61-66
9288798-6	1997	The amount of FITC-dextran within alginate implants strongly correlated with the number of LL2 carcinoma cells or B16/F10 cells encapsulated.	Alginates	34-42	peroxiredoxin 2, pseudogene 1	Mus musculus	91-94
9288798-8	1997	A more than 10-fold stimulation above that of controls was found with alginate implants containing 10(4) LL2 or B16/F10 tumor cells.	Alginates	70-78	peroxiredoxin 2, pseudogene 1	Mus musculus	105-108
9029251-9	1996	In vitro, parathyroid tissue encapsulated with amitogenic alginate releases approximately half of the PTH of the native tissue, not different from tissue encapsulated with the mitogenic alginate.	Alginates	58-66	parathyroid hormone	Rattus norvegicus	102-105
9040103-7	1997	Complexation of cisplatin with alginates, especially AL-1, inhibited the accumulation of Pt in the kidneys and reduced blood urea nitrogen elevation by cisplatin.	Alginates	31-40	ephrin A5	Mus musculus	53-57
9015354-0	1997	Immunological studies of SK2 hybridoma cells microencapsulated with alginate-poly(L)lysine-alginate (APA) membrane following allogeneic transplantation.	Alginates	68-76	skin antigen 2	Mus musculus	25-28
9455664-4	1997	Six months after induction of the annular lesion, AF cells isolated from the lesion produced significantly higher levels of decorin and biglycan in alginate bead culture than did cells from equivalent zones of the controls.	Alginates	148-156	biglycan	Homo sapiens	136-144
9401818-5	1997	In addition, tubes of alginate are described which will be suitable for the continuous supply of LIF to repaired peripheral nerve.	Alginates	22-30	LIF interleukin 6 family cytokine	Homo sapiens	97-100
8658961-0	1996	A bacteria-expressed mouse interleukin-1 receptor antagonist peptide protects alginate-poly-L-lysine-alginate microencapsulated rat islets against the suppressive effect of interleukin-1 beta in vitro.	Alginates	78-86	interleukin 1 beta	Rattus norvegicus	173-191
8703486-0	1996	Alginate, the slime exopolysaccharide of Pseudomonas aeruginosa, binds human leukocyte elastase, retards inhibition by alpha 1-proteinase inhibitor, and accelerates inhibition by secretory leukoprotease inhibitor.	Alginates	0-8	elastase, neutrophil expressed	Homo sapiens	77-95
8703486-1	1996	The interaction of alginate from Pseudomonas aeruginosa ATCC 39324 with human leukocyte elastase was studied by determining the effects of the polysaccharide on the amidolytic activity of the enzyme toward a range of synthetic peptide substrates of different length.	Alginates	19-27	elastase, neutrophil expressed	Homo sapiens	78-96
8703486-7	1996	Alginate has only a minor effect on the antielastase activities of elafin and a recombinant form of the isolated C-terminal domain of secretory leukoprotease inhibitor.	Alginates	0-8	peptidase inhibitor 3	Homo sapiens	67-73
8703486-8	1996	Based on these findings, alginate may be an important factor in determining the local distribution of leukocyte elastase and perturbing the overall protease-antiprotease balance in the infected lungs of cystic fibrosis patients.	Alginates	25-33	elastase, neutrophil expressed	Homo sapiens	102-120
8743959-12	1996	Chondrocytes derived from normal articular cartilage synthesised collagen types I, II and X when cultured in alginate but type X synthesis was lost when cultured on plastic.	Alginates	109-117	collagen type III alpha 1 chain	Gallus gallus	65-73
8648506-6	1996	Western blotting performed on the medium, EDTA/alginate, and lysate samples demonstrated the production of both the 220 and 320 kDa tenascin size variants and their differential compartmentalization within the culture system.	Alginates	47-55	tenascin C	Bos taurus	132-140
8648506-7	1996	Tenascin was incorporated into the alginate bead matrix at a constant rate of 3.8 micrograms/day.	Alginates	35-43	tenascin C	Bos taurus	0-8
7584318-12	1995	Long term intermittent stimulation of alginate bead cultures with TGF beta resulted in large increases in proteoglycan synthesis, increased aggregation of large proteoglycan monomers, and an increase in the production of the larger of two small proteoglycans, putatively, biglycan.	Alginates	38-46	biglycan	Ovis aries	272-280
8602469-0	1996	TNF production from peripheral blood mononuclear cells in diabetic patients after stimulation with alginate and lipopolysaccharide.	Alginates	99-107	tumor necrosis factor	Homo sapiens	0-3
8602469-2	1996	The authors earlier demonstrated that alginates enriched in mannuronic acid stimulate human monocytes to produce high levels of cytokines such as tumour necrosis factor (TNF), IL-1 IL-6.	Alginates	38-47	tumor necrosis factor	Homo sapiens	146-168
8602469-2	1996	The authors earlier demonstrated that alginates enriched in mannuronic acid stimulate human monocytes to produce high levels of cytokines such as tumour necrosis factor (TNF), IL-1 IL-6.	Alginates	38-47	tumor necrosis factor	Homo sapiens	170-173
8602469-2	1996	The authors earlier demonstrated that alginates enriched in mannuronic acid stimulate human monocytes to produce high levels of cytokines such as tumour necrosis factor (TNF), IL-1 IL-6.	Alginates	38-47	interleukin 1 alpha	Homo sapiens	176-185
8602469-3	1996	In this study the authors have measured the TNF production from peripheral blood mononuclear cells (PBMC) in different groups of insulin-dependent diabetes mellitus (IDDM) patients after stimulation with different alginates and lipopolysaccharide (LPS).	Alginates	214-223	tumor necrosis factor	Homo sapiens	44-47
8602469-5	1996	High-M alginate and LPS induced a dose-dependent TNF production in all groups and the production was significantly different from unstimulated cells.	Alginates	7-15	tumor necrosis factor	Homo sapiens	49-52
11859379-4	1996	IL-1 treatment of chondrocytes cultured in alginate resulted in increased synthesis of IL-6 and prostaglandins, but not leukotrienes.	Alginates	43-51	interleukin 1 alpha	Homo sapiens	0-4
11859379-4	1996	IL-1 treatment of chondrocytes cultured in alginate resulted in increased synthesis of IL-6 and prostaglandins, but not leukotrienes.	Alginates	43-51	interleukin 6	Homo sapiens	87-91
8585531-2	1995	The effects of 14- and 15-membered macrolides are inhibition of immunoreaction induced by alginate and their inhibitory effect on alginate production serving as an antigen at the GMD level.	Alginates	130-138	GDP-mannose 4,6-dehydratase	Homo sapiens	179-182
7558335-3	1995	We have previously shown that the P. aeruginosa algC gene is required for biosynthesis of alginate and lipopolysaccharide (M.J. Coyne, Jr., K.S.	Alginates	90-98	phosphomannomutase	Pseudomonas aeruginosa PAO1	48-52
8570305-4	1995	We found a positive correlation between serum complement-activation ability and IgG3 antibody levels to lipopolysaccharide (LPS), alginate, and a crude mixture of P. aeruginosa antigens (sonicate) in a group of patients with high levels of anti-Pseudomonas precipitins.	Alginates	130-138	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	80-84
7767437-0	1995	In vitro slow release profile of endothelial cell growth factor immobilized within calcium alginate microbeads.	Alginates	83-99	fibroblast growth factor 1	Homo sapiens	33-63
7629654-7	1995	The similar early profile may be due to the release of cytochrome-c from bound calcium alginate adsorbed to the outer leaflet of the liposome.	Alginates	79-95	cytochrome c, somatic	Homo sapiens	55-67
7767437-2	1995	We have investigated calcium alginate microbeads as a vehicle for the controlled slow-release of endothelial cell growth factor (ECGF).	Alginates	21-37	fibroblast growth factor 1	Homo sapiens	129-133
7767437-7	1995	Calcium alginate microbeads demonstrated a controlled and predictable rate of release and that the amount of ECGF delivered can be varied by varying the initial concentration of ECGF in the microbeads.	Alginates	0-16	fibroblast growth factor 1	Homo sapiens	109-113
7767437-2	1995	We have investigated calcium alginate microbeads as a vehicle for the controlled slow-release of endothelial cell growth factor (ECGF).	Alginates	21-37	fibroblast growth factor 1	Homo sapiens	97-127
7767437-7	1995	Calcium alginate microbeads demonstrated a controlled and predictable rate of release and that the amount of ECGF delivered can be varied by varying the initial concentration of ECGF in the microbeads.	Alginates	0-16	fibroblast growth factor 1	Homo sapiens	178-182
7767437-8	1995	Based on these observations we conclude that calcium alginate microbeads are a convenient and practical vehicle for sustained ECGF delivery.	Alginates	45-61	fibroblast growth factor 1	Homo sapiens	126-130
7711137-8	1994	When transfected mouse fibroblasts or myoblasts were enclosed in permselective alginate-poly-L-lysine alginate microcapsules, ADA activity was secreted from the microcapsules and the cells remained viable for over 5 months.	Alginates	79-87	adenosine deaminase	Mus musculus	126-129
7926496-3	1994	METHODS: Rats were treated with recombinant TGF-beta 1 in alginate beads perorally or with recombinant TGF-beta 1 in phosphate-buffered saline perorally or intraperitoneally.	Alginates	58-66	transforming growth factor, beta 1	Rattus norvegicus	44-54
7926496-9	1994	Histomorphometrical analysis showed a marked reduction in villus height (50%-70%) in the intestinal mucosa of animals treated perorally with recombinant TGF-beta 1 in alginate beads.	Alginates	167-175	transforming growth factor, beta 1	Rattus norvegicus	153-163
7926002-1	1994	Interleukin-1 alpha and beta induced the production of large amounts of nitric oxide by normal, human articular chondrocytes in alginate culture; at the same time the biosynthesis of proteoglycan was strongly suppressed.	Alginates	128-136	interleukin 1 alpha	Homo sapiens	0-19
18615439-2	1994	When mouse Ltk(-) fibroblasts transfected with the human growth hormone gene were enclosed within permselective microcapsules fabricated from alginate-polylysine-alginate, they continued to secrete human growth hormone at the same rates as the nonencapsulated cells.	Alginates	142-150	growth hormone 1	Homo sapiens	57-71
7945914-1	1994	We employed alginate-entrapped cells secreting recombinant murine interleukin-4 (IL-4) to study the effect of IL-4 on hematopoietic cells of normal mice.	Alginates	12-20	interleukin 4	Mus musculus	66-79
7516338-0	1994	Evaluation of magnetic alginate beads as a solid support for positive selection of CD34+ cells.	Alginates	23-31	CD34 molecule	Homo sapiens	83-87
7945914-1	1994	We employed alginate-entrapped cells secreting recombinant murine interleukin-4 (IL-4) to study the effect of IL-4 on hematopoietic cells of normal mice.	Alginates	12-20	interleukin 4	Mus musculus	81-85
8516335-1	1993	The intraperitoneal injection of insulin-producing islets immunoprotected by an alginate-poly(amino acid) membrane is a potential method of reversing diabetes without the need for lifelong immunosuppression.	Alginates	80-88	insulin	Homo sapiens	33-40
8399490-2	1993	We tested this strategy by encapsulating mouse Ltk- cells transfected with the human growth hormone (hGH) gene in immunoprotective perm-selective alginate microcapsules.	Alginates	146-154	leukocyte tyrosine kinase	Mus musculus	47-50
8399490-2	1993	We tested this strategy by encapsulating mouse Ltk- cells transfected with the human growth hormone (hGH) gene in immunoprotective perm-selective alginate microcapsules.	Alginates	146-154	growth hormone 1	Homo sapiens	85-99
8516335-3	1993	We have determined that key factors responsible for these past failures include cytokine (interleukins 1 and 6 and tumor necrosis factor) stimulation by mannuronic acid monomers from alginate capsules with weak mechanical integrity, which results in fibroblast proliferation.	Alginates	183-191	tumor necrosis factor	Homo sapiens	90-136
8244935-0	1993	Cloning and characterization of the Pseudomonas aeruginosa sodA and sodB genes encoding manganese- and iron-cofactored superoxide dismutase: demonstration of increased manganese superoxide dismutase activity in alginate-producing bacteria.	Alginates	211-219	superoxide dismutase	Pseudomonas aeruginosa PAO1	68-72
8376828-0	1993	Depletion of CD4 cells in mice with intraperitoneal injection of alginate-encapsulated GK 1.5 hybridoma cells: a potential use in development of animal models for infectious diseases.	Alginates	65-73	kallikrein 1-related peptidase b1	Mus musculus	87-91
7690290-2	1993	Genetically engineered rat fibroblasts producing NGF were encapsulated in an alginate-polylysine gel with the ultimate objective of improving transplantation methodologies.	Alginates	77-85	nerve growth factor	Rattus norvegicus	49-52
8478081-4	1993	TNF-alpha production was shown to depend strongly on the molecular weights of poly-M and high-M alginate, with maximal TNF-alpha production occurring at molecular weights above 50,000 and 200,000, respectively.	Alginates	96-104	tumor necrosis factor	Homo sapiens	0-9
8359197-1	1993	Interleukin-5-producing CV-1 cells were encapsulated in alginate and injected i.p.	Alginates	56-64	interleukin-5	Cavia porcellus	0-13
8478081-4	1993	TNF-alpha production was shown to depend strongly on the molecular weights of poly-M and high-M alginate, with maximal TNF-alpha production occurring at molecular weights above 50,000 and 200,000, respectively.	Alginates	96-104	tumor necrosis factor	Homo sapiens	119-128
8449870-4	1993	This same size restriction fragment contains the alginate gene algC, which encodes the enzyme phosphomannomutase (PMM) and also maps to this region of the P. aeruginosa chromosome.	Alginates	49-57	phosphomannomutase	Pseudomonas aeruginosa PAO1	94-112
8514239-6	1993	Single cells in alginate matrix had even more stable insulin secretion throughout the whole cultivation with significant increases to glucose challenge (p &lt; 0.01, &lt; 0.01 and &lt; 0.05).	Alginates	16-24	insulin	Homo sapiens	53-60
8449870-4	1993	This same size restriction fragment contains the alginate gene algC, which encodes the enzyme phosphomannomutase (PMM) and also maps to this region of the P. aeruginosa chromosome.	Alginates	49-57	phosphomannomutase	Pseudomonas aeruginosa PAO1	114-117
8449870-8	1993	We designate this gene pmm to emphasize that it encodes the enzyme PMM, which has been shown to be essential for alginate production, and we demonstrate that PMM activity is required for the LPS-smooth phenotype in P. aeruginosa PAO1.	Alginates	113-121	phosphomannomutase	Pseudomonas aeruginosa PAO1	23-26
8449870-8	1993	We designate this gene pmm to emphasize that it encodes the enzyme PMM, which has been shown to be essential for alginate production, and we demonstrate that PMM activity is required for the LPS-smooth phenotype in P. aeruginosa PAO1.	Alginates	113-121	phosphomannomutase	Pseudomonas aeruginosa PAO1	67-70
8155608-3	1993	Since macrophages are present in this reaction and interleukin-1 (IL-1), a cytokine released by activated macrophages, may induce fibrosis, we tested the capacity of alginate-polylysine microcapsules to activate macrophages.	Alginates	166-174	interleukin 1 alpha	Homo sapiens	51-64
8486419-8	1993	We conclude that the alginate matrix may act as a "spacer" creating a distance between the consuments of a lacking substrate esp.	Alginates	21-29	protein tyrosine phosphatase, receptor type, V	Rattus norvegicus	125-128
8399976-0	1993	Effect of alginate and calcium on secretion of IL-1 by immobilized Swiss peritoneal macrophages.	Alginates	10-18	interleukin 1 complex	Mus musculus	47-51
8399976-3	1993	Calcium and alginate individually enhance production of IL-1 by macrophages and act in synergy when macrophages are immobilized in calcium alginate matrix.	Alginates	12-20	interleukin 1 complex	Mus musculus	56-60
8155608-3	1993	Since macrophages are present in this reaction and interleukin-1 (IL-1), a cytokine released by activated macrophages, may induce fibrosis, we tested the capacity of alginate-polylysine microcapsules to activate macrophages.	Alginates	166-174	interleukin 1 alpha	Homo sapiens	66-70
8155608-8	1993	IL-1 beta release and intracellular IL-1 beta and IL-1 alpha production were significantly higher when macrophages were cultured with alginate-polylysine microcapsules than when macrophages were cultured alone.	Alginates	134-142	interleukin 1 beta	Homo sapiens	0-9
8155608-8	1993	IL-1 beta release and intracellular IL-1 beta and IL-1 alpha production were significantly higher when macrophages were cultured with alginate-polylysine microcapsules than when macrophages were cultured alone.	Alginates	134-142	interleukin 1 beta	Homo sapiens	36-45
8155608-8	1993	IL-1 beta release and intracellular IL-1 beta and IL-1 alpha production were significantly higher when macrophages were cultured with alginate-polylysine microcapsules than when macrophages were cultured alone.	Alginates	134-142	interleukin 1 alpha	Homo sapiens	50-60
1603034-6	1992	Decorin is also synthesized in small amounts but it is rapidly lost from the agarose or alginate gel.	Alginates	88-96	decorin	Homo sapiens	0-7
1851824-4	1991	Sodium alginate also induced significantly lower postprandial rises in blood glucose, serum insulin and plasma C-peptide.	Alginates	0-15	insulin	Homo sapiens	92-99
18600930-2	1992	The rate of diffusion of serum albumin (MW 6.9 x 10(4) D) out of beads of calcium alginate gels depends upon the concentration and uronic acid composition of the alginate (ManA/GulA ratio), the conditions under which the beads are produced, the pH, and the temperature.	Alginates	74-90	mannosidase alpha class 2C member 1	Homo sapiens	172-176
18600930-3	1992	The diffusion coefficient decreases with increasing alginate concentration, and (ManA/GulA) ratio and with decreasing pH.	Alginates	52-60	mannosidase alpha class 2C member 1	Homo sapiens	81-85
1544467-2	1992	Here we show by electron microscopy of alginate encapsulated islets, that islet cell lysis is induced by culturing islets for 24 or 48 h in the presence of IL-1 beta.	Alginates	39-47	interleukin 1 beta	Homo sapiens	156-165
1493195-1	1992	The rate of adsorption of aqueous emulsions of DMAEMA-MMA copolymers to calcium alginate substrates was examined using ATR FT-IR spectroscopy.	Alginates	72-88	ATR serine/threonine kinase	Homo sapiens	119-122
1664648-6	1991	Osteoblasts derived from the alginate beads elaborated and mineralized an extracellular matrix in vitro that contained fibronectin, type III collagen, and type I collagen.	Alginates	29-37	fibronectin 1	Gallus gallus	119-130
1931864-3	1991	In this study, we have examined the ability of alginates and their components to stimulate human monocytes to produce tumor necrosis factor-alpha, interleukin-6, and interleukin-1.	Alginates	47-56	interleukin 6	Homo sapiens	147-160
1931864-3	1991	In this study, we have examined the ability of alginates and their components to stimulate human monocytes to produce tumor necrosis factor-alpha, interleukin-6, and interleukin-1.	Alginates	47-56	interleukin 1 alpha	Homo sapiens	166-179
2135530-1	1990	Angle reproducibility and surface roughness were compared among stone casts obtained from two agar-alginate impression methods; 1) conventional method in which an alginate mix was applied before gelation of agar, and 2) improved method in which an alginate mix was applied to gelled agar.	Alginates	163-171	Mix paired-like homeobox	Homo sapiens	172-175
1933981-0	1991	An alginate pick-up alternative to the altered cast technique.	Alginates	3-11	protein interacting with PRKCA 1	Homo sapiens	12-16
16348353-3	1990	A similar pattern of release by immobilized SS1 was observed between 12 to 20 h after loading alginate beads in packed-bed reactors at the rate of 11.6 mumol mg of chlorophyll h.	Alginates	94-102	major histocompatibility complex, class II, DR beta 1	Homo sapiens	44-47
33799247-1	2021	In this work, an enteric soluble alginate was proposed to improve the absorption efficiency of cyanidin-3-O-glucoside (C3G) through molecular self-assembly.	Alginates	33-41	Rap guanine nucleotide exchange factor (GEF) 1	Mus musculus	119-122
2110181-2	1990	We developed enzyme-linked immunosorbent assays (ELISAs) for determination in serum of immunoglobulin A (IgA) and IgG antibodies to alginate purified from P. aeruginosa and an ELISA for detection of IgA antibodies to a polyvalent P. aeruginosa standard antigen.	Alginates	132-140	CD79a molecule	Homo sapiens	199-202
33803715-4	2021	The present study evaluated the influence of the recommended 25-kGy gamma-irradiation dose on the physicochemical characteristics and in vitro release of bovine serum albumin and vancomycin (an antibiotic medication) from alginate/gelatin with a w/w ratio of 1/4 crosslinking gel macrospheres.	Alginates	222-230	albumin	Homo sapiens	161-174
33794389-0	2021	Controlled Delivery of Slit3 Proteins from Alginate Microbeads Inhibits In Vitro Angiogenesis.	Alginates	43-51	slit guidance ligand 3	Homo sapiens	23-28
33794389-4	2021	METHODS: Slit3 labeled with I-125 was encapsulated in microbeads composed of low-viscosity alginate of high-glucuronic acid content, first coated with poly-L-ornithine for various durations and finally with low-viscosity high mannuronic acid.	Alginates	91-99	slit guidance ligand 3	Homo sapiens	9-14
33794389-7	2021	RESULTS: On incubation of Slit3-loaded microbeads, there was an initial burst phase release of Slit3 for the first 24 h followed by sustained release for 6 to 12 d. Microbead composition determined encapsulation efficiency and rate of release; Slit3 encapsulation was most efficient in microbeads with lower low-viscosity alginate of high-glucuronic acid content concentrations (1.5%) and no poly-L-ornithine coating.	Alginates	322-330	slit guidance ligand 3	Homo sapiens	26-31
33811984-3	2021	Alginate microparticles and collagen/hydroxyapatite scaffolds were shown to be effective PGF-delivery platforms, as demonstrated by their capacity to promote angiogenesis in vitro.	Alginates	0-8	placental growth factor	Rattus norvegicus	89-92
33812623-6	2021	We engineered and characterized borax-loaded alginate hydrogels for an effective activation of NaBC1 in vivo.	Alginates	45-53	solute carrier family 4, sodium bicarbonate transporter-like, member 11	Mus musculus	95-100
33794389-9	2021	CONCLUSIONS: Slit3 can be effectively encapsulated and delivered via a controlled release pattern using alginate microbeads.	Alginates	104-112	slit guidance ligand 3	Homo sapiens	13-18
33766799-2	2021	Herein, an interpenetrating network (IPN) of collagen and alginate 3D culture system with tunable extracellular microstructure and mechanics is exploited as a tumor stroma proxy to study phenotypic plasticity of colorectal cancer-associated fibroblasts (CAF).	Alginates	58-66	lysine acetyltransferase 2B	Homo sapiens	223-252
33766799-2	2021	Herein, an interpenetrating network (IPN) of collagen and alginate 3D culture system with tunable extracellular microstructure and mechanics is exploited as a tumor stroma proxy to study phenotypic plasticity of colorectal cancer-associated fibroblasts (CAF).	Alginates	58-66	lysine acetyltransferase 2B	Homo sapiens	254-257
33778405-14	2021	Moreover, the cell sorting experiments reveal that only Tie2+ cells were able to maintain the pluripotent gene expression if cultured in 3D within alginate beads.	Alginates	147-155	TEK receptor tyrosine kinase	Homo sapiens	56-60
33777525-12	2021	The mTG/GA and its composite hydrogels showed higher compressive moduli than the single-component chitosan and alginate hydrogels.	Alginates	111-119	protease, serine 3	Mus musculus	4-7
33816432-1	2021	Herein, a sodium alginate/poly (acrylic acid)/oxidized-multi-walled carbon nanotubes hydrogel nanocomposite (SA/p(AAc)/o-MWCNTs HNC) was synthesized by in situ free-radical polymerization method.	Alginates	10-25	glycine-N-acyltransferase	Homo sapiens	114-117
33806357-4	2021	The adsorption mechanism involves replacement of CaII by PbII ions coordinated to the carboxylate groups of the alginate backbone.	Alginates	112-120	carbonic anhydrase 2	Homo sapiens	49-53
34628120-2	2022	This study investigated the impact of pH 3-7 on the properties (e.g., surface structures of droplets, mechanical properties, storage stability, digestion behavior) of alginate gel beads containing soy protein isolate(SPI)-stabilized oil droplets.	Alginates	167-175	chromogranin A	Homo sapiens	217-220
34718182-4	2022	The drug-resistant MCF-7 breast cancer spheroids were able to maintain their drug-resistant phenotype of CD44high/CD24low/ALDH1high in the gelatin-alginate media during 3D culture and exhibited higher expression levels of drug resistance markers, such as GRP78 chaperon and ABCG2 transporter, than bulk MCF-7 breast cancer spheroids.	Alginates	147-155	CD44 molecule (Indian blood group)	Homo sapiens	105-109
34902389-0	2022	Facilely recoverable Pb(II) adsorbent based on greigite (Fe3S4) loaded alginate aerogel with high adsorption efficiency.	Alginates	71-79	submaxillary gland androgen regulated protein 3B	Homo sapiens	21-27
34936326-6	2022	After gelation with alginate, the optimized CCNZ1:Alg1.5 nanozyme hydrogel exhibits multiple functions, including inflamed site targeting, supporting cell growth, ROS scavenging, and antibacterial activity, which alleviates UC better than a clinical medication 5-aminosalicylic acid by even a single-dose treatment.	Alginates	20-28	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Homo sapiens	50-54
34718182-4	2022	The drug-resistant MCF-7 breast cancer spheroids were able to maintain their drug-resistant phenotype of CD44high/CD24low/ALDH1high in the gelatin-alginate media during 3D culture and exhibited higher expression levels of drug resistance markers, such as GRP78 chaperon and ABCG2 transporter, than bulk MCF-7 breast cancer spheroids.	Alginates	147-155	CD24 molecule	Homo sapiens	114-118
34718182-4	2022	The drug-resistant MCF-7 breast cancer spheroids were able to maintain their drug-resistant phenotype of CD44high/CD24low/ALDH1high in the gelatin-alginate media during 3D culture and exhibited higher expression levels of drug resistance markers, such as GRP78 chaperon and ABCG2 transporter, than bulk MCF-7 breast cancer spheroids.	Alginates	147-155	aldehyde dehydrogenase 1 family member A1	Homo sapiens	122-127
34757233-6	2022	Considering the biological performance, adipose derived stem cell cultures demonstrated monotonically increasing cell area and associated YAP/TAZ mechanosensing with increasing amounts of alginate from 0 to 2 wt.%, demonstrating the possibility for using DN hydrogels in guiding musculoskeletal differentiation.	Alginates	188-196	Yes1 associated transcriptional regulator	Homo sapiens	138-141
34738744-3	2022	In this study, poly-l-lysine/sodium alginate (PLS) is modified with talabostat (PT100) and encapsulates a PARP1 plasmid (PARP1@PLS-PT100) for delivery to target the dipeptidyl peptidase 4 (DPP4) receptor and eliminate SFs.	Alginates	29-44	poly(ADP-ribose) polymerase 1	Homo sapiens	106-111
34757233-6	2022	Considering the biological performance, adipose derived stem cell cultures demonstrated monotonically increasing cell area and associated YAP/TAZ mechanosensing with increasing amounts of alginate from 0 to 2 wt.%, demonstrating the possibility for using DN hydrogels in guiding musculoskeletal differentiation.	Alginates	188-196	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	142-145
34963101-2	2022	The influence of the addition amount of sodium alginate (SA) on the microstructure, porosity, pore size, swelling ratio, degradation ratio, mechanical properties and mineralization ability of BCA composite scaffolds is studied and characterized by various techniques of the scanning electron microscopy, X-ray diffraction, infrared absorption spectrometer and so on.	Alginates	40-55	acyl-CoA synthetase medium chain family member 3	Homo sapiens	57-59
34699694-2	2022	Here, we report a novel method by taking advantages of thermotropic liquid crystals -SDS liquid crystals (LCs) and rod-like crystal fragments (LCFs) to develop engineered alginate hydrogels with rod-like channels (diameter was 0.8331 +- 0.3077 mum).	Alginates	171-179	kinetochore associated 1	Homo sapiens	115-118
34699694-2	2022	Here, we report a novel method by taking advantages of thermotropic liquid crystals -SDS liquid crystals (LCs) and rod-like crystal fragments (LCFs) to develop engineered alginate hydrogels with rod-like channels (diameter was 0.8331 +- 0.3077 mum).	Alginates	171-179	kinetochore associated 1	Homo sapiens	195-198
34738744-3	2022	In this study, poly-l-lysine/sodium alginate (PLS) is modified with talabostat (PT100) and encapsulates a PARP1 plasmid (PARP1@PLS-PT100) for delivery to target the dipeptidyl peptidase 4 (DPP4) receptor and eliminate SFs.	Alginates	29-44	poly(ADP-ribose) polymerase 1	Homo sapiens	121-126
34738744-3	2022	In this study, poly-l-lysine/sodium alginate (PLS) is modified with talabostat (PT100) and encapsulates a PARP1 plasmid (PARP1@PLS-PT100) for delivery to target the dipeptidyl peptidase 4 (DPP4) receptor and eliminate SFs.	Alginates	29-44	dipeptidyl peptidase 4	Homo sapiens	165-187
34738744-3	2022	In this study, poly-l-lysine/sodium alginate (PLS) is modified with talabostat (PT100) and encapsulates a PARP1 plasmid (PARP1@PLS-PT100) for delivery to target the dipeptidyl peptidase 4 (DPP4) receptor and eliminate SFs.	Alginates	29-44	dipeptidyl peptidase 4	Homo sapiens	189-193
34145772-0	2022	Alginate oligosaccharide alleviates senile osteoporosis via the RANKL-RANK pathway in D-galactose-induced C57BL/6J mice.	Alginates	0-8	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	64-69
34839383-5	2022	Based on the direct sandwich immunoassay principle, dual-capturing antibodies were encapsulated into a single 3D porous calcium alginate bead as a proof-of-concept for multiplexity detection of serum-HER2 and serum-CA125 breast cancer biomarkers.	Alginates	120-136	mucin 16, cell surface associated	Homo sapiens	215-220
34743940-7	2021	HA-incorporated fibroin-alginate hydrogel had decreased pore size and porosity compared with pure alginate hydrogel.	Alginates	24-32	fibroin light chain	Bombyx mori	16-23
34856348-2	2022	A film of CS-SA unidirectional release drug-containing water-repellent layer EC was produced by interfacial reaction solvent-drying technique using self-made equipment.	Alginates	13-15	citrate synthase	Homo sapiens	10-12
34873828-7	2022	Therefore, 3D culture in alginate beads can be used to store or ship biological cells with ease at room temperature with minimal preparations.	Alginates	25-33	inositol polyphosphate-5-phosphatase D	Homo sapiens	64-68
34688674-0	2021	Effect of Ca2+ cross-linking on the properties and structure of lutein-loaded sodium alginate hydrogels.	Alginates	78-93	carbonic anhydrase 2	Homo sapiens	10-13
34757733-5	2021	On the other hand, an anti-programmed cell death 1 ligand 1 antibody (anti-PD-L1)-modified SA nanogel loaded with indocyanine green (ICG@SA-anti-PD-L1 nanogel) was prepared for diagnosing and inhibiting lung metastasis by assisting orthotopic tumor therapy.	Alginates	91-93	CD274 molecule	Homo sapiens	27-59
34757733-5	2021	On the other hand, an anti-programmed cell death 1 ligand 1 antibody (anti-PD-L1)-modified SA nanogel loaded with indocyanine green (ICG@SA-anti-PD-L1 nanogel) was prepared for diagnosing and inhibiting lung metastasis by assisting orthotopic tumor therapy.	Alginates	91-93	CD274 molecule	Homo sapiens	75-80
34757733-5	2021	On the other hand, an anti-programmed cell death 1 ligand 1 antibody (anti-PD-L1)-modified SA nanogel loaded with indocyanine green (ICG@SA-anti-PD-L1 nanogel) was prepared for diagnosing and inhibiting lung metastasis by assisting orthotopic tumor therapy.	Alginates	91-93	CD274 molecule	Homo sapiens	145-150
34757733-5	2021	On the other hand, an anti-programmed cell death 1 ligand 1 antibody (anti-PD-L1)-modified SA nanogel loaded with indocyanine green (ICG@SA-anti-PD-L1 nanogel) was prepared for diagnosing and inhibiting lung metastasis by assisting orthotopic tumor therapy.	Alginates	137-139	CD274 molecule	Homo sapiens	27-59
34757733-5	2021	On the other hand, an anti-programmed cell death 1 ligand 1 antibody (anti-PD-L1)-modified SA nanogel loaded with indocyanine green (ICG@SA-anti-PD-L1 nanogel) was prepared for diagnosing and inhibiting lung metastasis by assisting orthotopic tumor therapy.	Alginates	137-139	CD274 molecule	Homo sapiens	75-80
34757733-5	2021	On the other hand, an anti-programmed cell death 1 ligand 1 antibody (anti-PD-L1)-modified SA nanogel loaded with indocyanine green (ICG@SA-anti-PD-L1 nanogel) was prepared for diagnosing and inhibiting lung metastasis by assisting orthotopic tumor therapy.	Alginates	137-139	CD274 molecule	Homo sapiens	145-150
34968544-1	2022	In the work, a novel filamentou sodium alginate (SA) /epsilon-polylysine (PL) fiber with excellent mechanical properties and controllable sizes is prepared in an efficient and environmentally friendly manner via continuous pulling of an electrostatically assembled SA/PL composites at the contact interface of aqueous solutions of cationic polyelectrolyte epsilon-PL and anionic natural polysaccharide SA.	Alginates	32-47	acyl-CoA synthetase medium-chain family member 3	Mus musculus	49-51
34968544-1	2022	In the work, a novel filamentou sodium alginate (SA) /epsilon-polylysine (PL) fiber with excellent mechanical properties and controllable sizes is prepared in an efficient and environmentally friendly manner via continuous pulling of an electrostatically assembled SA/PL composites at the contact interface of aqueous solutions of cationic polyelectrolyte epsilon-PL and anionic natural polysaccharide SA.	Alginates	32-47	acyl-CoA synthetase medium-chain family member 3	Mus musculus	265-270
34968544-1	2022	In the work, a novel filamentou sodium alginate (SA) /epsilon-polylysine (PL) fiber with excellent mechanical properties and controllable sizes is prepared in an efficient and environmentally friendly manner via continuous pulling of an electrostatically assembled SA/PL composites at the contact interface of aqueous solutions of cationic polyelectrolyte epsilon-PL and anionic natural polysaccharide SA.	Alginates	32-47	acyl-CoA synthetase medium-chain family member 3	Mus musculus	402-404
34507097-5	2021	Bestowed with the feasibility analysis of fluorescent output, portable platform was designed by integrating UCNPS-embedded sodium alginate hydrogel with 3D-printed smartphone device for quantitatively on-site monitoring of carbaryl in the range of 0.5-200 ng mL-1 in tea sample, accompanied by a detection limit of 0.5 ng mL-1.	Alginates	123-138	L1 cell adhesion molecule	Mus musculus	259-263
34655589-0	2021	A facile approach for tuning optical and surface properties of novel biobased Alginate/POTE handleable films via solvent vapor exposure.	Alginates	78-86	POTE ankyrin domain family member D	Homo sapiens	87-91
34743940-11	2021	Increased ALP activity was observed in MC3T3-E1 cultured in HA-incorporated fibroin-alginate hydrogel.	Alginates	84-92	fibroin light chain	Bombyx mori	76-83
34449041-4	2021	Oligoalginates derived from 0.5% alginate (100 mg mL-1) showed the highest antioxidant activities in vitro.	Alginates	33-41	L1 cell adhesion molecule	Mus musculus	50-54
34959393-0	2021	Gelatin-Alginate Coacervates Optimized by DOE to Improve Delivery of bFGF for Wound Healing.	Alginates	8-16	fibroblast growth factor 2	Homo sapiens	69-73
34241755-4	2021	TGA and DSC results showed that the capsules have thermal stability in the range of 25-40  C. Viable cell counts were more effective in capsules containing 1% (w/v) sodium alginate, and the emulsification index showed a large increase (80%) from day 5, as well as surface tension had a large drop (48%) in the same period.	Alginates	165-180	desmocollin 3	Homo sapiens	8-11
34329149-3	2021	In this study, the FO concentration of sodium alginate (SA) was investigated using calcium chloride as a draw solute.	Alginates	39-54	acyl-CoA synthetase medium chain family member 3	Homo sapiens	56-58
34329149-5	2021	The properties of the concentrated substances formed on the FO membrane on the feed side were analyzed by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, verifying that calcium alginate (Ca-Alg), which can be used as a recycled material, was formed on the FO membrane on the feed side owing to the interaction between SA and permeable calcium ions.	Alginates	199-215	acyl-CoA synthetase medium chain family member 3	Homo sapiens	348-350
34329149-5	2021	The properties of the concentrated substances formed on the FO membrane on the feed side were analyzed by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, verifying that calcium alginate (Ca-Alg), which can be used as a recycled material, was formed on the FO membrane on the feed side owing to the interaction between SA and permeable calcium ions.	Alginates	217-223	acyl-CoA synthetase medium chain family member 3	Homo sapiens	348-350
34597726-2	2021	In this work, sodium alginate-cellulose nanofibers (SA-CNF) based inks loaded with curcumin and/or chloramphenicol have been developed for syringe extrusion 3D printing technology.	Alginates	14-29	NPHS1 adhesion molecule, nephrin	Homo sapiens	55-58
34797663-1	2021	The aim of this study was to fabricate ursolic acid (UA)-sodium alginate (SA) complexes to improve the dissolution rate and antioxidant abilities.	Alginates	57-72	acyl-CoA synthetase medium chain family member 3	Homo sapiens	74-76
34917593-3	2021	In this research, we established a bilayer coating with double-crosslinked hydrogels (alginate-gelatin methacrylate (GelMA)) containing bone morphogenic protein (BMP)-2 (alginate-GelMA/hydroxyapatite (HA)/BMP-2), which displayed great biocompatibility and osteogenesis.	Alginates	86-94	bone morphogenetic protein 2	Homo sapiens	205-210
34917593-9	2021	In brief, alginate-GelMA/HA/BMP-2 could increase the hBMSCs" early transformation of osteoblast lineage and promote the osteogenesis of bone defect, especially the outer hydrogel layer such as Alg70-Gel30 and Alg50-Gel50.	Alginates	10-18	bone morphogenetic protein 2	Homo sapiens	28-33
34510560-3	2021	Sodium alginate (SA) can take part in amyloid-like aggregation of the lysozyme, leading to the facile synthesis of a 2D protein/saccharide hybrid nanofilm over an ultralarge area (e.g., >400 cm2 ).	Alginates	0-15	lysozyme	Homo sapiens	70-78
34761522-3	2022	Here, polyacrylamide/copper-alginate double network (PAM/Cu-alg DN) hydrogel electrolyte was successfully synthesized by radiation-induced polymerization and cross-linking process of acrylamide with N, N"-methylene-bis-acrylamide and subsequent cupric ion (Cu2+ ) crosslinking of alginate.	Alginates	21-36	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	53-56
34761522-3	2022	Here, polyacrylamide/copper-alginate double network (PAM/Cu-alg DN) hydrogel electrolyte was successfully synthesized by radiation-induced polymerization and cross-linking process of acrylamide with N, N"-methylene-bis-acrylamide and subsequent cupric ion (Cu2+ ) crosslinking of alginate.	Alginates	280-288	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	53-56
34761522-4	2022	The content of sodium alginate, absorbed dose and the concentration of Cu2+ were investigated in detail for improving the overall properties of PAM/Cu-alg DN hydrogel electrolytes.	Alginates	15-30	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	144-147
34956477-3	2021	In this work, oxidized sodium alginate/aminated hyaluronic acid (OSA/AHA) hydrogel with various proportions was developed based on Schiff base reaction.	Alginates	23-38	Osa protein	Escherichia coli	65-68
34858956-6	2021	HepLPCs encapsulated in alginate beads are able to mitigate liver injury in mice treated with carbon tetrachloride (CCL4), while alginate coating protects the cells from immune attack.	Alginates	24-32	chemokine (C-C motif) ligand 4	Mus musculus	116-120
34510560-3	2021	Sodium alginate (SA) can take part in amyloid-like aggregation of the lysozyme, leading to the facile synthesis of a 2D protein/saccharide hybrid nanofilm over an ultralarge area (e.g., >400 cm2 ).	Alginates	17-19	lysozyme	Homo sapiens	70-78
34074175-13	2021	Western blotting revealed the increase of chondrocyte-associated proteins such as SOX9 and COL2A1 in phenolated-alginate-collagen hydrogels after 21 days.	Alginates	112-120	SRY-box transcription factor 9	Homo sapiens	82-86
34661961-2	2021	These ManNAc, ManA and ManNAcA residues found in many glycoconjugates, bacterial polysaccharides, and alginates have consistently captured interest of the glycoscience community both due to synthetic challenge and therapeutic potential.	Alginates	102-111	mannosidase alpha class 2C member 1	Homo sapiens	14-18
34074175-13	2021	Western blotting revealed the increase of chondrocyte-associated proteins such as SOX9 and COL2A1 in phenolated-alginate-collagen hydrogels after 21 days.	Alginates	112-120	collagen type II alpha 1 chain	Homo sapiens	91-97
34132482-0	2021	Surface modification of neurotrophin-3 loaded PCL/chitosan nanofiber/net by alginate hydrogel microlayer for enhanced biocompatibility in neural tissue engineering.	Alginates	76-84	neurotrophin 3	Homo sapiens	24-38
34372745-0	2021	pH-sensitive chitosan-deoxycholic acid/alginate nanoparticles for oral insulin delivery.	Alginates	39-47	insulin	Homo sapiens	71-78
34372745-2	2021	To improve delivery efficiency, chitosan conjugated deoxycholic acid (CS-DCA) coupled with sodium alginate (ALG) was prepared to load insulin into pH-sensitive nanoparticles.	Alginates	91-106	insulin	Homo sapiens	134-141
34372745-2	2021	To improve delivery efficiency, chitosan conjugated deoxycholic acid (CS-DCA) coupled with sodium alginate (ALG) was prepared to load insulin into pH-sensitive nanoparticles.	Alginates	108-111	insulin	Homo sapiens	134-141
34372745-3	2021	The insulin-loaded chitosan-deoxycholic acid/alginate nanoparticles (CDA NPs) were characterized by size (143.3 +- 10.8 nm), zeta potential (19.5 +- 1.6 mV), entrapment efficiency (61.14 +- 1.67%) and insulin drug loading (3.36 +- 0.09%).	Alginates	45-53	insulin	Homo sapiens	4-11
34711698-9	2021	Retinol treatment could induce a high expression of rhodopsin protein in MSCs expanded in alginate and alginate-gelatin mixtures.	Alginates	90-98	rhodopsin	Mus musculus	52-61
34711698-9	2021	Retinol treatment could induce a high expression of rhodopsin protein in MSCs expanded in alginate and alginate-gelatin mixtures.	Alginates	103-111	rhodopsin	Mus musculus	52-61
34711698-10	2021	An elevated presentation of Nestin, RPE65 and Rhodopsin genes was detected in retinol-treated cultures expanded on alginate and alginate-gelatin scaffolds.	Alginates	115-123	nestin	Mus musculus	28-34
34711698-10	2021	An elevated presentation of Nestin, RPE65 and Rhodopsin genes was detected in retinol-treated cultures expanded on alginate and alginate-gelatin scaffolds.	Alginates	115-123	retinal pigment epithelium 65	Mus musculus	36-41
34711698-10	2021	An elevated presentation of Nestin, RPE65 and Rhodopsin genes was detected in retinol-treated cultures expanded on alginate and alginate-gelatin scaffolds.	Alginates	115-123	rhodopsin	Mus musculus	46-55
34711698-10	2021	An elevated presentation of Nestin, RPE65 and Rhodopsin genes was detected in retinol-treated cultures expanded on alginate and alginate-gelatin scaffolds.	Alginates	128-136	nestin	Mus musculus	28-34
34711698-10	2021	An elevated presentation of Nestin, RPE65 and Rhodopsin genes was detected in retinol-treated cultures expanded on alginate and alginate-gelatin scaffolds.	Alginates	128-136	retinal pigment epithelium 65	Mus musculus	36-41
34711698-10	2021	An elevated presentation of Nestin, RPE65 and Rhodopsin genes was detected in retinol-treated cultures expanded on alginate and alginate-gelatin scaffolds.	Alginates	128-136	rhodopsin	Mus musculus	46-55
34716519-1	2022	In this study, chitosan/sodium alginate/nano cellulose (CSA-N) nanocomposite hydrogels were prepared using a completely green route and used as sorbents to adsorb Cd2+ ions from water and soil systems of an environmental aspect.	Alginates	24-39	CD2 molecule	Homo sapiens	163-166
34614488-1	2021	Insecticide cartap hydrochloride (C) was fabricated as nanospheres by a two-step method of ionic gelification and polyelectrolyte complexation of alginate (ALG) and chitosan (CS) to undermine its adverse effects on environment.	Alginates	146-154	citrate synthase	Homo sapiens	175-177
34769095-0	2021	Complexation of CXCL12, FGF-2 and VEGF with Heparin Modulates the Protein Release from Alginate Microbeads.	Alginates	87-95	C-X-C motif chemokine ligand 12	Homo sapiens	16-22
34769095-0	2021	Complexation of CXCL12, FGF-2 and VEGF with Heparin Modulates the Protein Release from Alginate Microbeads.	Alginates	87-95	fibroblast growth factor 2	Homo sapiens	24-29
34769095-0	2021	Complexation of CXCL12, FGF-2 and VEGF with Heparin Modulates the Protein Release from Alginate Microbeads.	Alginates	87-95	vascular endothelial growth factor A	Homo sapiens	34-38