PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25218038-10	2015	A further study showed that the 5-HT1B receptor agonist CP94253 (3-10 mg/kg) mimics the fluoxetine potentiation of methylphenidate-induced gene regulation.	CP 94253	56-63	5-hydroxytryptamine receptor 1B	Homo sapiens	32-38
25665528-6	2015	RESULTS: Vortioxetine enhanced the inhibitory effect of the stimulation of the 5-HT bundle at a high, but not low frequency and reversed the inhibitory effect of the 5-HT1B receptor agonist CP 94253.	CP 94253	190-198	5-hydroxytryptamine receptor 1B	Rattus norvegicus	166-172
25286119-6	2015	Activation of rat 5-HT1B autoreceptor in axon terminals by CP-94253 did not modulate FADD forms.	CP 94253	59-67	5-hydroxytryptamine receptor 1B	Rattus norvegicus	18-24
25181578-6	2014	Furthermore, pre-training intra-CA1 injection of subthreshold dose of CP94253 (0.05 ng/mouse) or GR127935 (0.005 ng/mouse) reversed impairment of memory acquisition induced by harmaline (1 mg/kg, i.p.).	CP 94253	70-77	carbonic anhydrase 1	Mus musculus	32-35
22516841-10	2012	The serotoninergic 5-HT(1A) and 5-HT(1B) agonists (8-OH-DPAT and CP94253 respectively) altered the temporal profile of the rotational behaviour supporting a regulatory role.	CP 94253	65-72	5-hydroxytryptamine receptor 1A	Rattus norvegicus	19-26
22961814-6	2012	The selective 5-HT(1B) antagonist SB224289 decreased SERT activity in synaptosomes prepared from wild-type but not 5-HT(1B) knockout mice, whereas SERT uptake was enhanced after pretreatment with the selective 5-HT(1B) agonist CP94253.	CP 94253	227-234	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	14-21
22961814-6	2012	The selective 5-HT(1B) antagonist SB224289 decreased SERT activity in synaptosomes prepared from wild-type but not 5-HT(1B) knockout mice, whereas SERT uptake was enhanced after pretreatment with the selective 5-HT(1B) agonist CP94253.	CP 94253	227-234	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	147-151
22579773-8	2012	In addition, activation of 5-HT(1A) and 5-HT(1B) receptors by 8-OH-DPAT and CP 94253, known to inhibit the activity of 5-HT neurons, significantly reduced GID, whereas induction of neurotransmitter release by fenfluramine administration significantly increased GID, indicating an involvement of the 5-HT system in the modulation of GID.	CP 94253	76-84	5-hydroxytryptamine receptor 1A	Rattus norvegicus	27-34
22542420-8	2012	The shift in the direction of the treatment effect from acute to chronic, using the 5-HT(1B) agonist, CP-94253, on 5-HT synthesis in the FSL model of depression, with an opposite effect on the control FRL rats, suggests the differential adaptation of the 5-HT system in the FSL and FRL rats to chronic stimulation of 5-HT(1B) receptors.	CP 94253	102-110	5-hydroxytryptamine receptor 1B	Rattus norvegicus	84-91
22542420-8	2012	The shift in the direction of the treatment effect from acute to chronic, using the 5-HT(1B) agonist, CP-94253, on 5-HT synthesis in the FSL model of depression, with an opposite effect on the control FRL rats, suggests the differential adaptation of the 5-HT system in the FSL and FRL rats to chronic stimulation of 5-HT(1B) receptors.	CP 94253	102-110	5-hydroxytryptamine receptor 1B	Rattus norvegicus	317-324
24145075-6	2013	The 5-HT1B receptor agonist CP 94253 (1.25-5 mg/kg) also inhibited the amphetamine-seeking behavior induced by amphetamine (1.5 mg/kg) but not by the cue combined with the threshold dose of amphetamine.	CP 94253	28-36	5-hydroxytryptamine receptor 1B	Rattus norvegicus	4-10
22305629-10	2012	The 5-HT(1F) agonist (LY-344864) was effective in the dura mater (26% iCGRP inhibition), and the 5-HT(1D) agonist (PNU-142633) had a significant effect in the TNC (48%), whereas the 5-HT(1B) agonist (CP-94253) was unable to reduce the iCGRP release in all tissues studied.	CP 94253	200-208	5-hydroxytryptamine receptor 1D	Rattus norvegicus	97-104
19650818-2	2009	We revisited this issue by examining the effects of a 5-HT(1B)R agonist, CP94253, on cocaine reinforcement and cocaine-primed reinstatement, predicting that CP94253 would enhance cocaine-seeking behavior reinstated by a low priming dose, similar to its effect on cocaine reinforcement.	CP 94253	73-80	5-hydroxytryptamine receptor 1B	Rattus norvegicus	54-61
21353664-4	2011	METHODS: We manipulated 5-HT(1B) autoreceptor function in rats using either viral-mediated gene transfer into the caudal DRN or systemic injections of the 5-HT(1B) agonist 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b]pyridine (CP-94253).	CP 94253	172-236	5-hydroxytryptamine receptor 1B	Rattus norvegicus	24-31
21353664-4	2011	METHODS: We manipulated 5-HT(1B) autoreceptor function in rats using either viral-mediated gene transfer into the caudal DRN or systemic injections of the 5-HT(1B) agonist 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b]pyridine (CP-94253).	CP 94253	172-236	5-hydroxytryptamine receptor 1B	Rattus norvegicus	155-162
19650818-2	2009	We revisited this issue by examining the effects of a 5-HT(1B)R agonist, CP94253, on cocaine reinforcement and cocaine-primed reinstatement, predicting that CP94253 would enhance cocaine-seeking behavior reinstated by a low priming dose, similar to its effect on cocaine reinforcement.	CP 94253	157-164	5-hydroxytryptamine receptor 1B	Rattus norvegicus	54-61
19211971-7	2008	The 5-HT(1B) receptor agonist CP 94253 (2.5 or 5 mg/kg) combined with a subthreshold priming dose of cocaine (2.5 mg/kg) potentiated reinstatement of the drug seeking-behavior, but inhibited cocaine seeking induced by a submaximal dose (10 mg/kg) of cocaine or the cocaine-associated cue.	CP 94253	30-38	5-hydroxytryptamine receptor 1B	Rattus norvegicus	4-11
18048951-8	2007	The results showed that 5-HT1B agonists RU24969 and CP94253 produced partial generalization of 48% and 60%, respectively, and the 5-HT1B antagonist GR127935 neither substituted for AMPH nor affected the discriminative cue of AMPH; however, when RU24969 or CP94253 were administrated in combination with AMPH, they increased the discriminative cue of AMPH.	CP 94253	52-59	5-hydroxytryptamine receptor 1B	Rattus norvegicus	24-30
18256188-6	2008	Using unilaterally 6-OHDA-lesioned p11 WT and KO mice, it was found that administration of a selective 5-HT1B receptor agonist, CP94253, inhibited L-DOPA-induced rotational behavior and abnormal involuntary movements in a p11-dependent manner.	CP 94253	128-135	S100 calcium binding protein A10 (calpactin)	Mus musculus	35-38
18256188-6	2008	Using unilaterally 6-OHDA-lesioned p11 WT and KO mice, it was found that administration of a selective 5-HT1B receptor agonist, CP94253, inhibited L-DOPA-induced rotational behavior and abnormal involuntary movements in a p11-dependent manner.	CP 94253	128-135	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	103-118
18256188-6	2008	Using unilaterally 6-OHDA-lesioned p11 WT and KO mice, it was found that administration of a selective 5-HT1B receptor agonist, CP94253, inhibited L-DOPA-induced rotational behavior and abnormal involuntary movements in a p11-dependent manner.	CP 94253	128-135	S100 calcium binding protein A10 (calpactin)	Mus musculus	222-225
16959056-4	2007	Moreover, CP 94253 (5-10 mg/kg), a selective 5-HT1B receptor agonist, exerted appetite-suppressing effects and significantly increased hypothalamic pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) gene expression and decreased hypothalamic orexin gene expression.	CP 94253	10-18	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	45-60
16959056-4	2007	Moreover, CP 94253 (5-10 mg/kg), a selective 5-HT1B receptor agonist, exerted appetite-suppressing effects and significantly increased hypothalamic pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) gene expression and decreased hypothalamic orexin gene expression.	CP 94253	10-18	pro-opiomelanocortin-alpha	Mus musculus	148-168
16959056-4	2007	Moreover, CP 94253 (5-10 mg/kg), a selective 5-HT1B receptor agonist, exerted appetite-suppressing effects and significantly increased hypothalamic pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) gene expression and decreased hypothalamic orexin gene expression.	CP 94253	10-18	pro-opiomelanocortin-alpha	Mus musculus	170-174
16959056-4	2007	Moreover, CP 94253 (5-10 mg/kg), a selective 5-HT1B receptor agonist, exerted appetite-suppressing effects and significantly increased hypothalamic pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) gene expression and decreased hypothalamic orexin gene expression.	CP 94253	10-18	CART prepropeptide	Mus musculus	180-225
16959056-4	2007	Moreover, CP 94253 (5-10 mg/kg), a selective 5-HT1B receptor agonist, exerted appetite-suppressing effects and significantly increased hypothalamic pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) gene expression and decreased hypothalamic orexin gene expression.	CP 94253	10-18	CART prepropeptide	Mus musculus	227-231
16959056-4	2007	Moreover, CP 94253 (5-10 mg/kg), a selective 5-HT1B receptor agonist, exerted appetite-suppressing effects and significantly increased hypothalamic pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) gene expression and decreased hypothalamic orexin gene expression.	CP 94253	10-18	hypocretin	Mus musculus	276-282
15577451-7	2004	The results indicate that the selective agonist (CP 94253) and antagonists (SB 216641 and GR 127935) of 5-HT1B receptors produce effects that are characteristic of anxiolytics, in the preclinical models used; however, CP 94253 also behaves like an antidepressant drug.	CP 94253	49-57	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	104-110
16765343-0	2006	Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice.	CP 94253	63-71	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	39-54
16765343-6	2006	The obtained results suggest that CP 94253 exerts anticonvulsant activity on pentylenetetrazol-induced seizures in mice, as a consequence of stimulation of 5-HT1B receptors (probably located postsynaptically and/or as heteroreceptors); the antiseizure activity of RU 24969 seems to depend on the stimulation of both 5-HT1A and 5-HT1B receptors.	CP 94253	34-42	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	156-162
16765343-6	2006	The obtained results suggest that CP 94253 exerts anticonvulsant activity on pentylenetetrazol-induced seizures in mice, as a consequence of stimulation of 5-HT1B receptors (probably located postsynaptically and/or as heteroreceptors); the antiseizure activity of RU 24969 seems to depend on the stimulation of both 5-HT1A and 5-HT1B receptors.	CP 94253	34-42	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	316-333
16212943-8	2005	The results also showed that intra-tegmental infusion of CP 94253, a 5-HT1B receptor agonist, significantly prolonged the effects of ethanol on NACC DA.	CP 94253	57-65	5-hydroxytryptamine receptor 1B	Rattus norvegicus	69-75
15913599-0	2005	Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action.	CP 94253	68-76	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	44-59
15913599-1	2005	The mechanism of the antidepressant-like activity of the selective 5-hydroxytryptamine(1B) (5-HT(1B)) receptor agonist 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine (CP 94253) was studied in the forced swimming test in mice.	CP 94253	191-199	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	92-110
15913599-4	2005	The obtained results suggest that the anti-immobility effect of CP 94253 is mediated by activation of 5-HT(1B) receptors-most probably located postsynaptically and/or as heteroreceptors, and that the dopamine and the noradrenaline systems are involved in this action.	CP 94253	64-72	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	102-109
15577451-7	2004	The results indicate that the selective agonist (CP 94253) and antagonists (SB 216641 and GR 127935) of 5-HT1B receptors produce effects that are characteristic of anxiolytics, in the preclinical models used; however, CP 94253 also behaves like an antidepressant drug.	CP 94253	218-226	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	104-110
10191333-3	1999	In wild-type mice, the 5-HT1B agonists CP 94253 (1-10 mg/kg, i.p.)	CP 94253	39-47	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	23-29
12040075-7	2002	However, 5-HT(1B) receptor stimulation by CP 94253 (1-3 mg/kg, i.p.)	CP 94253	42-50	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	9-26
11888549-4	2002	The selective 5-HT(1B) receptor agonist 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b]pyridine (CP 94,253; 1--5.6 mg/kg) dose-dependently decreased the amount of exploration on the open arms of the plus-maze without altering overall locomotor activity.	CP 94253	40-104	5-hydroxytryptamine receptor 1B	Rattus norvegicus	14-21
11453104-7	2001	In substitution tests, the selective 5-HT1B receptor agonist 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b]pyridine (CP 94253; 2.5-5 mg/kg, i.p.)	CP 94253	61-125	5-hydroxytryptamine receptor 1B	Rattus norvegicus	37-43
11453104-7	2001	In substitution tests, the selective 5-HT1B receptor agonist 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b]pyridine (CP 94253; 2.5-5 mg/kg, i.p.)	CP 94253	127-135	5-hydroxytryptamine receptor 1B	Rattus norvegicus	37-43
9203237-1	1997	The selective 5-HT1B agonist CP-94,253 (3- (1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3, 2-b] pyridine) (5-40 mumol/kg) reduced the intake of both pellets and a 10% solution of sucrose (ID50 = 12.5 and 22.8 mumol/kg, respectively) in mildly deprived rats.	CP 94253	40-107	5-hydroxytryptamine receptor 1B	Rattus norvegicus	14-20
34816290-0	2022	Effects of repeated treatment with the 5-HT1A and 5-HT1B agonists (R)-( +)-8-hydroxy-DPAT and CP-94253 on the locomotor activity and axillary temperatures of preweanling rats: evidence of tolerance and behavioral sensitization.	CP 94253	94-102	5-hydroxytryptamine receptor 1B	Rattus norvegicus	50-56
8090811-1	1994	This study tested whether a new serotonin (5-HT1B) agonist, 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxy-pyrrolo[3,2-b]pyridine (CP-93,129), could be used to study the potential role of 5-HT1B receptors in the secretion of adrenocorticotropic hormone (ACTH), prolactin, and renin.	CP 94253	60-125	5-hydroxytryptamine receptor 1B	Rattus norvegicus	43-49
28720013-6	2017	We thus investigated whether the 5-HT1B receptor also modifies methylphenidate-induced gene regulation, by assessing effects of a selective 5-HT1B receptor agonist (CP94253) on immediate-early gene markers ( Zif268, c- Fos, Homer1a) in adolescent male rats.	CP 94253	165-172	early growth response 1	Rattus norvegicus	208-214
32172944-5	2020	In both VTA slices and the VTA of anesthetized mice, the 5-HT1B/1DR agonist CP94253 decreased DA neuronal firing rate and evoked excitatory postsynaptic currents to DA neurons in slice.	CP 94253	76-83	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	57-63
30946562-3	2019	We generated a stable 5-HT1B receptor-expressing Neuro2A (N2A-1B) neuronal cell line and demonstrate that activation of these receptors by the selective 5-HT1B agonist CP-94253 results in activation of ERK1/2 but not of other closely related MAP kinases.	CP 94253	168-176	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	22-37
30946562-3	2019	We generated a stable 5-HT1B receptor-expressing Neuro2A (N2A-1B) neuronal cell line and demonstrate that activation of these receptors by the selective 5-HT1B agonist CP-94253 results in activation of ERK1/2 but not of other closely related MAP kinases.	CP 94253	168-176	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	22-28
30946562-3	2019	We generated a stable 5-HT1B receptor-expressing Neuro2A (N2A-1B) neuronal cell line and demonstrate that activation of these receptors by the selective 5-HT1B agonist CP-94253 results in activation of ERK1/2 but not of other closely related MAP kinases.	CP 94253	168-176	mitogen-activated protein kinase 3	Mus musculus	202-208
31042352-8	2019	CP94253 given before the expression test, but not acutely in drug-naive mice, enhanced FOS+ cells in the VTA, the nucleus accumbens (NAc) shell and core, and the dorsomedial striatum and reversed the Meth-conditioned changes in FOS in the BlA and CeA.	CP 94253	0-7	FBJ osteosarcoma oncogene	Mus musculus	87-90
31042352-8	2019	CP94253 given before the expression test, but not acutely in drug-naive mice, enhanced FOS+ cells in the VTA, the nucleus accumbens (NAc) shell and core, and the dorsomedial striatum and reversed the Meth-conditioned changes in FOS in the BlA and CeA.	CP 94253	0-7	FBJ osteosarcoma oncogene	Mus musculus	228-231
32873441-3	2020	In contrast, increased fear responses to unpredictable threat were blocked by 5-HT1A-R agonist Buspirone (given before conditioning or retrieval) and 5-HT1B-R agonist CP-94253 (applied before training).	CP 94253	167-175	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	150-156
28380327-7	2017	In addition, pre-training intra-CA1 injection of sub-threshold dose of CP94253 (0.05ng/mouse) and alpha-methyl 5-HT (5ng/mouse) potentiated impairment of memory acquisition induced by harmane (12mg/kg, i.p.).	CP 94253	71-78	carbonic anhydrase 1	Mus musculus	32-35
28720013-8	2017	Our results show that CP94253 (3, 10 mg/kg) produced a dose-dependent potentiation of methylphenidate (5 mg/kg)-induced expression of Zif268 and c- Fos.	CP 94253	22-29	early growth response 1	Rattus norvegicus	134-140
28720013-8	2017	Our results show that CP94253 (3, 10 mg/kg) produced a dose-dependent potentiation of methylphenidate (5 mg/kg)-induced expression of Zif268 and c- Fos.	CP 94253	22-29	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	145-151