PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25216522-6	2014	STAT3 inhibitors, AG 490 and piplartine (PL) induced anoikis in a concentration-dependent manner in anoikis resistant cells.	piplartine	41-43	signal transducer and activator of transcription 3	Mus musculus	0-5
25216522-7	2014	Over-expression of STAT3 or treatment with IL-6 not only increased anoikis resistance, but also protected the cancer cells from PL-induced anoikis.	piplartine	128-130	signal transducer and activator of transcription 3	Mus musculus	19-24
25216522-7	2014	Over-expression of STAT3 or treatment with IL-6 not only increased anoikis resistance, but also protected the cancer cells from PL-induced anoikis.	piplartine	128-130	interleukin 6	Mus musculus	43-47
16751987-7	2006	The antitumor activity of piplartine was related to inhibition of the tumor proliferation rate, as observed by reduction of Ki67 staining, a nuclear antigen associated with G1, S, G2, and M cell cycle phases, in tumors from treated animals.	piplartine	26-36	antigen identified by monoclonal antibody Ki 67	Mus musculus	124-128
23124161-1	2012	As a continuation of our efforts directed towards the development of anti-diabetic agents from natural sources, piplartine was isolated from Piper chaba, and was found to inhibit recombinant human ALR2 with an IC(50) of 160 muM.	piplartine	112-122	aldo-keto reductase family 1 member B	Homo sapiens	197-201
19501152-7	2009	In PCC4 cells, piplartine inhibited the cell cycle progression by inactivating cdk2 and destabilizing cyclin D1, whereas diferuloylmethane combination inhibited the ERK1/2 and Raf-1 signaling in addition to the inhibition of cell cycle progression.	piplartine	15-25	cyclin-dependent kinase 2	Mus musculus	79-83
19298699-3	2009	METHODS: We evaluated the in-vitro antiplatelet effect of piplartine isolated from the roots of P. tuberculatum, on human platelet aggregation induced in platelet-rich plasma by the agonists collagen, adenosine 5"-diphosphate (ADP), arachidonic acid (AA) and thrombin.	piplartine	58-68	coagulation factor II, thrombin	Homo sapiens	259-267
19298699-6	2009	The highest concentration of piplartine (300 mug/ml) inhibited thrombin- (37%), ADP- (71%) and collagen- (98%) induced aggregation.	piplartine	29-39	coagulation factor II, thrombin	Homo sapiens	63-71
18813819-8	2008	Higher concentrations (24-30 microM) of piplartine modulated apoptosis-related protein expression by down-regulating cdc-2 expression and up-regulating PARP/procaspase-3 cleavage.	piplartine	40-50	cyclin dependent kinase 1	Homo sapiens	117-122
18813819-8	2008	Higher concentrations (24-30 microM) of piplartine modulated apoptosis-related protein expression by down-regulating cdc-2 expression and up-regulating PARP/procaspase-3 cleavage.	piplartine	40-50	collagen type XI alpha 2 chain	Homo sapiens	152-156
18813819-8	2008	Higher concentrations (24-30 microM) of piplartine modulated apoptosis-related protein expression by down-regulating cdc-2 expression and up-regulating PARP/procaspase-3 cleavage.	piplartine	40-50	caspase 3	Homo sapiens	157-169
18813819-9	2008	Also, PC-3 cells treated with piplartine demonstrated caspase-3 activation, as observed with an in vitro caspase-3 colorimetric assay kit.	piplartine	30-40	caspase 3	Homo sapiens	54-63
18813819-9	2008	Also, PC-3 cells treated with piplartine demonstrated caspase-3 activation, as observed with an in vitro caspase-3 colorimetric assay kit.	piplartine	30-40	caspase 3	Homo sapiens	105-114
18813819-10	2008	Taken together, these results demonstrated that high concentrations of piplartine exhibited anti-proliferative and anti-cancer effects on PC-3 cells and that caspase-3-mediated PARP cleavage and cell cycle arrest at G2/M phase are involved in the underlying cellular mechanism of the apoptosis process.	piplartine	71-81	caspase 3	Homo sapiens	158-167
18813819-10	2008	Taken together, these results demonstrated that high concentrations of piplartine exhibited anti-proliferative and anti-cancer effects on PC-3 cells and that caspase-3-mediated PARP cleavage and cell cycle arrest at G2/M phase are involved in the underlying cellular mechanism of the apoptosis process.	piplartine	71-81	collagen type XI alpha 2 chain	Homo sapiens	177-181
19501152-7	2009	In PCC4 cells, piplartine inhibited the cell cycle progression by inactivating cdk2 and destabilizing cyclin D1, whereas diferuloylmethane combination inhibited the ERK1/2 and Raf-1 signaling in addition to the inhibition of cell cycle progression.	piplartine	15-25	cyclin D1	Mus musculus	102-111
19501152-8	2009	The over expression of heat shock protein 70, Hsp70 in rat histiocytic tumor cells interfered with piplartine induced cytotoxicity, hence, a cross talk between stress response and anticancer agents is presented.	piplartine	99-109	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	23-44
19501152-8	2009	The over expression of heat shock protein 70, Hsp70 in rat histiocytic tumor cells interfered with piplartine induced cytotoxicity, hence, a cross talk between stress response and anticancer agents is presented.	piplartine	99-109	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	46-51
16971088-7	2007	The increase in caspase-3 activity was also observed in lysates of piplartine-treated cells (2.5 microg/ml).	piplartine	67-77	caspase 3	Homo sapiens	16-25
30359932-0	2019	A novel platinum complex containing a piplartine derivative exhibits enhanced cytotoxicity, causes oxidative stress and triggers apoptotic cell death by ERK/p38 pathway in human acute promyelocytic leukemia HL-60 cells.	piplartine	38-48	mitogen-activated protein kinase 3	Homo sapiens	153-156
31207322-0	2019	Piplartine suppresses proliferation and invasion of hepatocellular carcinoma by LINC01391-modulated Wnt/beta-catenin pathway inactivation through ICAT.	piplartine	0-10	long intergenic non-protein coding RNA 1391	Homo sapiens	80-89
31207322-0	2019	Piplartine suppresses proliferation and invasion of hepatocellular carcinoma by LINC01391-modulated Wnt/beta-catenin pathway inactivation through ICAT.	piplartine	0-10	catenin beta 1	Homo sapiens	104-116
31136859-0	2019	An investigation into the interaction between piplartine (piperlongumine) and human serum albumin.	piplartine	46-56	albumin	Rattus norvegicus	84-97
34207356-0	2021	Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-kappaB Signaling Pathway and NLRP3 Inflammasome Activation.	piplartine	21-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	89-98
34207356-0	2021	Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-kappaB Signaling Pathway and NLRP3 Inflammasome Activation.	piplartine	21-31	NLR family, pyrin domain containing 3	Mus musculus	121-126
34207356-3	2021	The results demonstrated that piplartine suppresses iNOS and COX-2 expression, reduces PGE2, TNF-alpha and IL-6 production, decreases the phosphorylation of MAPKs and NF-kappaB and attenuates NF-kappaB activity by LPS-activated macrophages.	piplartine	30-40	nitric oxide synthase 2, inducible	Mus musculus	52-56
34207356-3	2021	The results demonstrated that piplartine suppresses iNOS and COX-2 expression, reduces PGE2, TNF-alpha and IL-6 production, decreases the phosphorylation of MAPKs and NF-kappaB and attenuates NF-kappaB activity by LPS-activated macrophages.	piplartine	30-40	cytochrome c oxidase II, mitochondrial	Mus musculus	61-66
34207356-3	2021	The results demonstrated that piplartine suppresses iNOS and COX-2 expression, reduces PGE2, TNF-alpha and IL-6 production, decreases the phosphorylation of MAPKs and NF-kappaB and attenuates NF-kappaB activity by LPS-activated macrophages.	piplartine	30-40	tumor necrosis factor	Mus musculus	93-102
34207356-3	2021	The results demonstrated that piplartine suppresses iNOS and COX-2 expression, reduces PGE2, TNF-alpha and IL-6 production, decreases the phosphorylation of MAPKs and NF-kappaB and attenuates NF-kappaB activity by LPS-activated macrophages.	piplartine	30-40	interleukin 6	Mus musculus	107-111
34207356-3	2021	The results demonstrated that piplartine suppresses iNOS and COX-2 expression, reduces PGE2, TNF-alpha and IL-6 production, decreases the phosphorylation of MAPKs and NF-kappaB and attenuates NF-kappaB activity by LPS-activated macrophages.	piplartine	30-40	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	167-176
34207356-3	2021	The results demonstrated that piplartine suppresses iNOS and COX-2 expression, reduces PGE2, TNF-alpha and IL-6 production, decreases the phosphorylation of MAPKs and NF-kappaB and attenuates NF-kappaB activity by LPS-activated macrophages.	piplartine	30-40	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	192-201
34207356-4	2021	Piplartine also inhibits IL-1beta production and suppresses NLRP3 inflammasome activation by LPS/ATP- and LPS/nigericin-activated macrophages.	piplartine	0-10	interleukin 1 alpha	Mus musculus	25-33
34207356-4	2021	Piplartine also inhibits IL-1beta production and suppresses NLRP3 inflammasome activation by LPS/ATP- and LPS/nigericin-activated macrophages.	piplartine	0-10	NLR family, pyrin domain containing 3	Mus musculus	60-65
34207356-5	2021	Moreover, piplartine reduces the production of nitric oxide (NO) and TNF-alpha, IL-6 and IL-1beta, decreases LPS-induced tissue damage, attenuates infiltration of inflammatory cells and enhances the survival rate.	piplartine	10-20	tumor necrosis factor	Mus musculus	69-78
34207356-5	2021	Moreover, piplartine reduces the production of nitric oxide (NO) and TNF-alpha, IL-6 and IL-1beta, decreases LPS-induced tissue damage, attenuates infiltration of inflammatory cells and enhances the survival rate.	piplartine	10-20	interleukin 6	Mus musculus	80-84
34207356-5	2021	Moreover, piplartine reduces the production of nitric oxide (NO) and TNF-alpha, IL-6 and IL-1beta, decreases LPS-induced tissue damage, attenuates infiltration of inflammatory cells and enhances the survival rate.	piplartine	10-20	interleukin 1 alpha	Mus musculus	89-97
33335138-4	2020	Molecular docking data and physicochemical analysis suggested that PL shows potential interactions with a peptide of annexin A1 (ANXA1), an endogenous anti-inflammatory mediator with therapeutic potential in cancer.	piplartine	67-69	annexin A1	Homo sapiens	117-127
33335138-4	2020	Molecular docking data and physicochemical analysis suggested that PL shows potential interactions with a peptide of annexin A1 (ANXA1), an endogenous anti-inflammatory mediator with therapeutic potential in cancer.	piplartine	67-69	annexin A1	Homo sapiens	129-134
33335138-5	2020	Treatment of neoplastic cells with PL alone or with annexin A1 mimic peptide reduced cell proliferation and viability and modulated the expression of MCP-1 chemokine, IL-8 cytokine and genes involved in inflammatory processes.	piplartine	35-37	annexin A1	Homo sapiens	52-62
33335138-5	2020	Treatment of neoplastic cells with PL alone or with annexin A1 mimic peptide reduced cell proliferation and viability and modulated the expression of MCP-1 chemokine, IL-8 cytokine and genes involved in inflammatory processes.	piplartine	35-37	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
31207322-0	2019	Piplartine suppresses proliferation and invasion of hepatocellular carcinoma by LINC01391-modulated Wnt/beta-catenin pathway inactivation through ICAT.	piplartine	0-10	catenin beta interacting protein 1	Homo sapiens	146-150
31207322-6	2019	Upregulation of LINC01391 induced by piplartine inhibited HCC cell proliferation, invasion in vitro, and tumor growth in vivo.	piplartine	37-47	long intergenic non-protein coding RNA 1391	Homo sapiens	16-25
31136859-3	2019	The present study investigated the interaction between piplartine and human serum albumin (HSA) the predominant protein in blood plasma.	piplartine	55-65	albumin	Rattus norvegicus	76-89
31334116-0	2019	Ruthenium Complexes With Piplartine Cause Apoptosis Through MAPK Signaling by a p53-Dependent Pathway in Human Colon Carcinoma Cells and Inhibit Tumor Development in a Xenograft Model.	piplartine	25-35	tumor protein p53	Homo sapiens	80-83
30359932-2	2019	In the present study, we synthesized a novel platinum complex containing a piplartine derivative cis-[PtCl(PIP-OH)(PPh3)2]PF6 (where, PIP-OH = piplartine demethylated derivative; and PPh3 = triphenylphosphine) with enhanced cytotoxicity in different cancer cells, and investigated its apoptotic action in human promyelocytic leukemia HL-60 cells.	piplartine	75-85	prolactin induced protein	Homo sapiens	107-110
30359932-2	2019	In the present study, we synthesized a novel platinum complex containing a piplartine derivative cis-[PtCl(PIP-OH)(PPh3)2]PF6 (where, PIP-OH = piplartine demethylated derivative; and PPh3 = triphenylphosphine) with enhanced cytotoxicity in different cancer cells, and investigated its apoptotic action in human promyelocytic leukemia HL-60 cells.	piplartine	75-85	caveolin 1	Homo sapiens	115-119
30359932-2	2019	In the present study, we synthesized a novel platinum complex containing a piplartine derivative cis-[PtCl(PIP-OH)(PPh3)2]PF6 (where, PIP-OH = piplartine demethylated derivative; and PPh3 = triphenylphosphine) with enhanced cytotoxicity in different cancer cells, and investigated its apoptotic action in human promyelocytic leukemia HL-60 cells.	piplartine	75-85	sperm associated antigen 17	Homo sapiens	122-125
30359932-2	2019	In the present study, we synthesized a novel platinum complex containing a piplartine derivative cis-[PtCl(PIP-OH)(PPh3)2]PF6 (where, PIP-OH = piplartine demethylated derivative; and PPh3 = triphenylphosphine) with enhanced cytotoxicity in different cancer cells, and investigated its apoptotic action in human promyelocytic leukemia HL-60 cells.	piplartine	75-85	prolactin induced protein	Homo sapiens	134-137
30359932-2	2019	In the present study, we synthesized a novel platinum complex containing a piplartine derivative cis-[PtCl(PIP-OH)(PPh3)2]PF6 (where, PIP-OH = piplartine demethylated derivative; and PPh3 = triphenylphosphine) with enhanced cytotoxicity in different cancer cells, and investigated its apoptotic action in human promyelocytic leukemia HL-60 cells.	piplartine	75-85	caveolin 1	Homo sapiens	183-187
30359932-2	2019	In the present study, we synthesized a novel platinum complex containing a piplartine derivative cis-[PtCl(PIP-OH)(PPh3)2]PF6 (where, PIP-OH = piplartine demethylated derivative; and PPh3 = triphenylphosphine) with enhanced cytotoxicity in different cancer cells, and investigated its apoptotic action in human promyelocytic leukemia HL-60 cells.	piplartine	143-153	prolactin induced protein	Homo sapiens	107-110
30359932-2	2019	In the present study, we synthesized a novel platinum complex containing a piplartine derivative cis-[PtCl(PIP-OH)(PPh3)2]PF6 (where, PIP-OH = piplartine demethylated derivative; and PPh3 = triphenylphosphine) with enhanced cytotoxicity in different cancer cells, and investigated its apoptotic action in human promyelocytic leukemia HL-60 cells.	piplartine	143-153	caveolin 1	Homo sapiens	115-119
30359932-2	2019	In the present study, we synthesized a novel platinum complex containing a piplartine derivative cis-[PtCl(PIP-OH)(PPh3)2]PF6 (where, PIP-OH = piplartine demethylated derivative; and PPh3 = triphenylphosphine) with enhanced cytotoxicity in different cancer cells, and investigated its apoptotic action in human promyelocytic leukemia HL-60 cells.	piplartine	143-153	sperm associated antigen 17	Homo sapiens	122-125
30359932-9	2019	In conclusion, the complex exhibits more potent cytotoxicity than piplartine in a panel of different cancer cells and triggers ROS/ERK/p38-mediated apoptosis in HL-60 cells.	piplartine	66-76	mitogen-activated protein kinase 3	Homo sapiens	131-134
30359932-9	2019	In conclusion, the complex exhibits more potent cytotoxicity than piplartine in a panel of different cancer cells and triggers ROS/ERK/p38-mediated apoptosis in HL-60 cells.	piplartine	66-76	mitogen-activated protein kinase 1	Homo sapiens	135-138
30359932-0	2019	A novel platinum complex containing a piplartine derivative exhibits enhanced cytotoxicity, causes oxidative stress and triggers apoptotic cell death by ERK/p38 pathway in human acute promyelocytic leukemia HL-60 cells.	piplartine	38-48	mitogen-activated protein kinase 1	Homo sapiens	157-160
25411359-8	2015	Interleukin-6 treatment and overexpression of STAT3 enhanced anoikis resistance and protected the cells from PL-induced anoikis.	piplartine	109-111	interleukin 6	Mus musculus	0-13
29921756-7	2018	In contrast, based on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry assays, piplartine exhibited toxicity in mammalian cells at 785 microM, while its analogues 19A and 6B did not reduce cell viability at the same concentrations.	piplartine	116-126	SLAM family member 7	Homo sapiens	200-210
25411359-8	2015	Interleukin-6 treatment and overexpression of STAT3 enhanced anoikis resistance and protected the cells from PL-induced anoikis.	piplartine	109-111	signal transducer and activator of transcription 3	Mus musculus	46-51