PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2827377-2 1988 Identification of the dissociation products of the isolated oligomer and comparison of the number of N-linked glycans in native and denatured NS1 is consistent with the idea that the high-molecular-weight form of NS1 is a homodimer. n-linked glycans 101-117 influenza virus NS1A binding protein Homo sapiens 213-216 3143729-9 1988 The mature form of MGA (MGAm) bears in addition to N-linked glycans also O-glycosidically linked oligosaccharides. n-linked glycans 51-67 maltase-glucoamylase Homo sapiens 19-22 3143729-9 1988 The mature form of MGA (MGAm) bears in addition to N-linked glycans also O-glycosidically linked oligosaccharides. n-linked glycans 51-67 maltase-glucoamylase Homo sapiens 24-28 3346246-15 1988 Our data on the biosynthesis show that the early MAM-6 precursors contain N-linked glycans, suggesting the presence of N-linked glycans on the mature MAM-6 molecule. n-linked glycans 74-90 mucin 1, cell surface associated Homo sapiens 49-54 3346246-15 1988 Our data on the biosynthesis show that the early MAM-6 precursors contain N-linked glycans, suggesting the presence of N-linked glycans on the mature MAM-6 molecule. n-linked glycans 74-90 mucin 1, cell surface associated Homo sapiens 150-155 3346246-15 1988 Our data on the biosynthesis show that the early MAM-6 precursors contain N-linked glycans, suggesting the presence of N-linked glycans on the mature MAM-6 molecule. n-linked glycans 119-135 mucin 1, cell surface associated Homo sapiens 49-54 3346246-15 1988 Our data on the biosynthesis show that the early MAM-6 precursors contain N-linked glycans, suggesting the presence of N-linked glycans on the mature MAM-6 molecule. n-linked glycans 119-135 mucin 1, cell surface associated Homo sapiens 150-155 2523254-1 1989 Our earlier studies revealed that N-acetylglucosaminyltransferase III (GnTase III), which catalyzes the insertion of a bisecting N-acetylglucosamine (bi-Gn) in the complex-type N-linked glycans of cellular glycoproteins, is present in hepatic nodules promoted by the orotic acid model. n-linked glycans 177-193 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Rattus norvegicus 34-69 2538547-0 1989 Role of N-linked glycans in the interaction between the envelope glycoprotein of human immunodeficiency virus and its CD4 cellular receptor. n-linked glycans 8-24 CD4 molecule Homo sapiens 118-121 3084653-9 1986 This considerable charge heterogeneity is consistent with the possibility that other posttranslational modifications to the mouse IL 2 receptor occur besides addition of complex N-linked glycans. n-linked glycans 178-194 interleukin 2 Mus musculus 130-134 3301835-8 1987 The N-linked glycans on human and mouse glycoprotein IIa are all of the complex type. n-linked glycans 4-20 ATPase, class II, type 9A Mus musculus 53-56 6098655-10 1984 Neither Mr = 33,000 and 24,000 fragment appear to be substrates for endo-beta-N-acetylglucosaminidase F. These data allow us to conclude that the hepatic glucagon receptor in the membrane is a dimer of approximately 60,000 dalton hormone binding subunit which is a glycoprotein containing at least four N-linked glycans accounting for 18,000 daltons of its mass. n-linked glycans 303-319 glucagon receptor Homo sapiens 154-171 2870429-6 1986 Digestion of Thy-1 with endo-beta-galactosidase suggested that the complex type N-linked glycans in thymocytes, but not in lymph node T-cells, contained increased levels of polylactosamine. n-linked glycans 80-96 thymus cell antigen 1, theta Mus musculus 13-18 2870429-6 1986 Digestion of Thy-1 with endo-beta-galactosidase suggested that the complex type N-linked glycans in thymocytes, but not in lymph node T-cells, contained increased levels of polylactosamine. n-linked glycans 80-96 galactosidase, beta 1 Mus musculus 29-47 34012659-11 2021 We also observed the increased ER degradation-enhancing alpha-mannosidase-like protein 3 (EDEM3), which is trimming of N-linked glycans by sequential removal of mannose residues, might result in more non-N-glycosylated form of BST-2. n-linked glycans 119-135 ER degradation enhancing alpha-mannosidase like protein 3 Homo sapiens 31-88 34013301-2 2021 Cross-reactive antibodies specifically recognized the sialic acid moiety on N-linked glycans of the Spike protein and do not neutralize in vitro SARS-CoV-2. n-linked glycans 76-92 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 100-105 34012659-11 2021 We also observed the increased ER degradation-enhancing alpha-mannosidase-like protein 3 (EDEM3), which is trimming of N-linked glycans by sequential removal of mannose residues, might result in more non-N-glycosylated form of BST-2. n-linked glycans 119-135 ER degradation enhancing alpha-mannosidase like protein 3 Homo sapiens 90-95 34012659-11 2021 We also observed the increased ER degradation-enhancing alpha-mannosidase-like protein 3 (EDEM3), which is trimming of N-linked glycans by sequential removal of mannose residues, might result in more non-N-glycosylated form of BST-2. n-linked glycans 119-135 bone marrow stromal cell antigen 2 Homo sapiens 227-232 33607086-12 2021 After removing N-linked glycans on ACE2, its mechanical binding strength with CoV-2 RBD decreases to a similar level of the CoV-1 RBD-ACE2 interaction. n-linked glycans 15-31 angiotensin converting enzyme 2 Homo sapiens 35-39 33669676-4 2021 While the envelope (Env) protein is the only viral protein present on the surface of virions, it exists in a complex trimeric conformation and is decorated with an array of variable N-linked glycans, making it an important but difficult target for vaccine design. n-linked glycans 182-198 endogenous retrovirus group K member 20 Homo sapiens 20-23 33758835-2 2021 The abundance of N-linked glycans across the SARS-CoV-2 spike protein is a potential source of heterogeneity between the many different vaccine candidates under investigation. n-linked glycans 17-33 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 56-61 33134321-6 2020 We used structural modeling to test this idea, and show that N-linked glycans appear to restrict torsinA"s ability to form closed homohexameric ring assemblies, and instead promote an open hexameric conformation that allows torsinA interaction with key cofactors required for ATP hydrolysis. n-linked glycans 61-77 torsin family 1 member A Homo sapiens 97-104 33301684-4 2021 Herein, we introduce a radically simplified sample preparation workflow, with direct ESI-MS analysis, enabling the quantification of N-linked glycans that originate from uromodulin. n-linked glycans 133-149 uromodulin Homo sapiens 170-180 32915505-0 2020 Structural characterization of the N-linked glycans in the receptor binding domain of the SARS-CoV-2 spike protein and their interactions with human lectins using NMR spectroscopy. n-linked glycans 35-51 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 101-106 33292056-0 2022 Sensing the interactions between carbohydrate-binding agents and N-linked glycans of SARS-CoV-2 spike glycoprotein using molecular docking and simulation studies. n-linked glycans 65-81 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 96-101 33292056-2 2022 The homotrimeric transmembrane spike (S) glycoprotein of coronaviruses which facilitates virus entry into the host cells is covered with N-linked glycans having oligomannose and complex sugars. n-linked glycans 137-153 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 31-36 33093196-1 2020 The dense array of N-linked glycans on the HIV-1 envelope glycoprotein (Env), known as the "glycan shield," is a key determinant of immunogenicity, yet intrinsic heterogeneity confounds typical structure-function analysis. n-linked glycans 19-35 endogenous retrovirus group K member 20 Homo sapiens 49-70 33093196-1 2020 The dense array of N-linked glycans on the HIV-1 envelope glycoprotein (Env), known as the "glycan shield," is a key determinant of immunogenicity, yet intrinsic heterogeneity confounds typical structure-function analysis. n-linked glycans 19-35 endogenous retrovirus group K member 20 Homo sapiens 72-75 33134321-6 2020 We used structural modeling to test this idea, and show that N-linked glycans appear to restrict torsinA"s ability to form closed homohexameric ring assemblies, and instead promote an open hexameric conformation that allows torsinA interaction with key cofactors required for ATP hydrolysis. n-linked glycans 61-77 torsin family 1 member A Homo sapiens 224-231 32675574-1 2020 PURPOSE OF REVIEW: The surface of the HIV-1 Env glycoprotein, the target of neutralizing antibodies, is extensively covered by N-linked glycans that create a glycan shield. n-linked glycans 127-143 endogenous retrovirus group K member 20 Homo sapiens 44-47 32699088-2 2020 For enveloped viruses such as the influenza A virus (IAV), the addition of large N-linked glycans can also prevent access to epitopes on the surface antigens hemagglutinin (HA or H) and neuraminidase (NA or N). n-linked glycans 81-97 neuraminidase 1 Homo sapiens 186-199 32356523-2 2020 It has been demonstrated that the carbohydrate-recognition domain (CRD) of ERGIC-53 (ERGIC-53CRD) interacts with N-linked glycans on cargo glycoproteins, whereas MCFD2 recognizes polypeptide segments of cargo glycoproteins. n-linked glycans 113-129 lectin, mannose binding 1 Homo sapiens 75-83 32454127-3 2020 In prion disease, the N-linked glycans and GPI-anchor on the prion protein (PrP) impair fibril assembly. n-linked glycans 22-38 prion protein Mus musculus 76-79 32766576-12 2020 After the removal of N-linked glycans on ACE2, its mechanical binding strength with CoV-2 RBD decreases to a similar level of the CoV-1 RBD-ACE2 interaction. n-linked glycans 21-37 angiotensin converting enzyme 2 Homo sapiens 41-45 32766576-12 2020 After the removal of N-linked glycans on ACE2, its mechanical binding strength with CoV-2 RBD decreases to a similar level of the CoV-1 RBD-ACE2 interaction. n-linked glycans 21-37 angiotensin converting enzyme 2 Homo sapiens 140-144 32108991-3 2020 Furthermore, N-linked glycans within the A2-domain have been shown to protect VWF against premature LRP1-mediated clearance. n-linked glycans 13-29 Von Willebrand factor Mus musculus 78-81 32108991-3 2020 Furthermore, N-linked glycans within the A2-domain have been shown to protect VWF against premature LRP1-mediated clearance. n-linked glycans 13-29 low density lipoprotein receptor-related protein 1 Mus musculus 100-104 32203567-5 2020 Genomic and structural analyses reveal that beta-catenin/CBP signaling represses fucosylation on the antennae of N-linked glycans on EGFR. n-linked glycans 113-129 catenin beta 1 Homo sapiens 44-56 32203567-5 2020 Genomic and structural analyses reveal that beta-catenin/CBP signaling represses fucosylation on the antennae of N-linked glycans on EGFR. n-linked glycans 113-129 CREB binding protein Homo sapiens 57-60 32203567-5 2020 Genomic and structural analyses reveal that beta-catenin/CBP signaling represses fucosylation on the antennae of N-linked glycans on EGFR. n-linked glycans 113-129 epidermal growth factor receptor Homo sapiens 133-137 32356523-2 2020 It has been demonstrated that the carbohydrate-recognition domain (CRD) of ERGIC-53 (ERGIC-53CRD) interacts with N-linked glycans on cargo glycoproteins, whereas MCFD2 recognizes polypeptide segments of cargo glycoproteins. n-linked glycans 113-129 lectin, mannose binding 1 Homo sapiens 85-96 32157792-5 2020 Mechanistically, we showed that GLT1D1 transferred N-linked glycans to PD-L1, thus promoting the immunosuppressive function of glycosylated PD-L1. n-linked glycans 51-67 glycosyltransferase 1 domain containing 1 Mus musculus 32-38 32157792-5 2020 Mechanistically, we showed that GLT1D1 transferred N-linked glycans to PD-L1, thus promoting the immunosuppressive function of glycosylated PD-L1. n-linked glycans 51-67 CD274 antigen Mus musculus 71-76 32157792-5 2020 Mechanistically, we showed that GLT1D1 transferred N-linked glycans to PD-L1, thus promoting the immunosuppressive function of glycosylated PD-L1. n-linked glycans 51-67 CD274 antigen Mus musculus 140-145 31471298-1 2019 OBJECTIVE: Anti-citrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA) patients display a unique feature defined by the abundant presence of N-linked glycans within the variable domains (V-domains). n-linked glycans 155-171 proteinase 3 Homo sapiens 50-54 31996426-7 2020 Pretreatment of EHV1 virions with eBD2 and -3 increased the subsequent infection of rabbit kidney (RK13) cells, which was dependent on viral N-linked glycans. n-linked glycans 141-157 ebd2 and -3 None 34-45 31636418-8 2019 In contrast, polymorphic sites and N-linked glycans are preferentially found in exposed positions on the receptor surface, not contacting transferrin, suggesting that transferrin receptor diversification is driven by a need for antigenic variation in the receptor to prolong survival in a host. n-linked glycans 35-51 transferrin receptor Homo sapiens 167-187 30973186-1 2019 The biological activity of the glycoprotein hormone erythropoietin (EPO) is dependent mainly on the structure of its N-linked glycans. n-linked glycans 117-133 erythropoietin Homo sapiens 52-66 31266804-8 2019 Deletion of the mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (MGAT1), necessary for the generation of complex N-linked glycans, abrogated TRPC6 gain-of-function variant-mediated Ca2+ influx and extracellular signal-regulated kinase activation in HEK cells, but failed to diminish cytotoxicity in cultured podocytes. n-linked glycans 141-157 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Homo sapiens 93-98 31266804-8 2019 Deletion of the mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (MGAT1), necessary for the generation of complex N-linked glycans, abrogated TRPC6 gain-of-function variant-mediated Ca2+ influx and extracellular signal-regulated kinase activation in HEK cells, but failed to diminish cytotoxicity in cultured podocytes. n-linked glycans 141-157 transient receptor potential cation channel subfamily C member 6 Homo sapiens 169-174 31667130-5 2019 Selective DPAGT1 inhibitors have the promising therapeutic potential for certain solid cancers that require increased branching of N-linked glycans in their growth progressions. n-linked glycans 131-147 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 Rattus norvegicus 10-16 31336133-6 2019 The aim of the present study was to compare the influence of ANITVNITV peptide fusion on the physicochemical, biological and pharmacokinetic properties of native hIFN-alpha2b (IFNwt), which contains a single O-glycosylation site, and a hyperglycosylated variant (IFN4N), that bears, in addition, 4 N-linked glycans. n-linked glycans 298-314 interferon alpha 2 Homo sapiens 162-174 31364612-4 2019 For a standard protein ovalbumin digest, 26 N-linked glycans were identified with good repeatability, and the detection limit was as low as 0.25 ng muL-1 with the identification of 13 N-linked glycans (S/N > 10). n-linked glycans 184-200 mitochondrial E3 ubiquitin protein ligase 1 Homo sapiens 148-153 31308178-4 2019 Here, using glycoside hydrolase and kinase assays and immunoprecipitation and MS-based analyses, we demonstrate that N-linked glycans at the Asn-247 site in VEGFR2 hinder VEGF ligand-mediated receptor activation and signaling in endothelial cells. n-linked glycans 117-133 kinase insert domain receptor Homo sapiens 157-163 31308178-4 2019 Here, using glycoside hydrolase and kinase assays and immunoprecipitation and MS-based analyses, we demonstrate that N-linked glycans at the Asn-247 site in VEGFR2 hinder VEGF ligand-mediated receptor activation and signaling in endothelial cells. n-linked glycans 117-133 vascular endothelial growth factor A Homo sapiens 157-161 30973186-1 2019 The biological activity of the glycoprotein hormone erythropoietin (EPO) is dependent mainly on the structure of its N-linked glycans. n-linked glycans 117-133 erythropoietin Homo sapiens 68-71 30842877-4 2019 Detailed mass spectrometric structural analysis showed an increase in disialo-biantennary N-linked glycans on IgA1 from BCa patients (p < 0.0001: non-core fucosylated; p = 0.0345: core fucosylated) and increased asialo-Thomsen-Friedenreich antigen (TF) and disialo-TF antigens in the O-linked glycan preparations from IgA1 of cancer patients compared with healthy control individuals. n-linked glycans 90-106 immunoglobulin heavy constant alpha 1 Homo sapiens 110-114 31311973-4 2019 Using structures as a guide, we show that the N-linked glycans at the interface of GluK3 ATD and LBD likely mediate inter-domain interactions and attune receptor-gating properties. n-linked glycans 46-62 glutamate ionotropic receptor kainate type subunit 3 Homo sapiens 83-88 31211781-0 2019 Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated alpha-Synuclein. n-linked glycans 18-34 synuclein alpha Homo sapiens 90-105 30842877-4 2019 Detailed mass spectrometric structural analysis showed an increase in disialo-biantennary N-linked glycans on IgA1 from BCa patients (p < 0.0001: non-core fucosylated; p = 0.0345: core fucosylated) and increased asialo-Thomsen-Friedenreich antigen (TF) and disialo-TF antigens in the O-linked glycan preparations from IgA1 of cancer patients compared with healthy control individuals. n-linked glycans 90-106 immunoglobulin heavy constant alpha 1 Homo sapiens 321-325 30476078-7 2019 Interestingly, Lewisx was mainly carried by N-linked glycans in both MC38-FUT4 and MC38-FUT9 cells, despite pronounced differences in the biosynthetic properties and the expression stability of the induced enzymes. n-linked glycans 44-60 fucosyltransferase 4 Mus musculus 15-21 30737276-3 2019 The structures of the four N-linked glycans from the PBCV-1 MCP consist of nonasaccharides, and similar glycans are not found elsewhere in the three domains of life. n-linked glycans 27-43 Major capsid protein Paramecium bursaria Chlorella virus 1 60-63 30740857-13 2019 CLEC4M binding to recombinant FVIII was dependent on mannose-exposed N-linked glycans. n-linked glycans 69-85 C-type lectin domain family 4 member M Homo sapiens 0-6 30740857-13 2019 CLEC4M binding to recombinant FVIII was dependent on mannose-exposed N-linked glycans. n-linked glycans 69-85 coagulation factor VIII Homo sapiens 30-35 30476078-7 2019 Interestingly, Lewisx was mainly carried by N-linked glycans in both MC38-FUT4 and MC38-FUT9 cells, despite pronounced differences in the biosynthetic properties and the expression stability of the induced enzymes. n-linked glycans 44-60 fucosyltransferase 9 Mus musculus 88-92 30375453-9 2018 Systems with N-linked glycans encountered higher energy barriers for full unfolding and even for unfolding up to the point of ADAMTS13 cleavage site exposure. n-linked glycans 13-29 ADAM metallopeptidase with thrombospondin type 1 motif 13 Homo sapiens 126-134 30355496-1 2018 Densely arranged N-linked glycans shield the HIV-1 envelope (Env) trimer from antibody recognition. n-linked glycans 17-33 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 51-59 30355496-1 2018 Densely arranged N-linked glycans shield the HIV-1 envelope (Env) trimer from antibody recognition. n-linked glycans 17-33 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 61-64 30054538-9 2018 To test whether the microglial response is mediated by carbohydrate epitopes on PrPSc surface, the levels of sialylation of PrPSc N-linked glycans was altered by treatment of purified PrPSc with neuraminidase. n-linked glycans 130-146 prion protein Mus musculus 124-129 30021839-1 2018 Endoplasmic reticulum (ER) degradation-enhancing alpha-mannosidase-like 1 protein (EDEM1) is a protein quality control factor that was initially proposed to recognize N-linked glycans on misfolded proteins through its mannosidase-like domain (MLD). n-linked glycans 167-183 ER degradation enhancing alpha-mannosidase like protein 1 Homo sapiens 0-73 30021839-1 2018 Endoplasmic reticulum (ER) degradation-enhancing alpha-mannosidase-like 1 protein (EDEM1) is a protein quality control factor that was initially proposed to recognize N-linked glycans on misfolded proteins through its mannosidase-like domain (MLD). n-linked glycans 167-183 ER degradation enhancing alpha-mannosidase like protein 1 Homo sapiens 83-88 29983388-2 2018 We have found an unexplored mechanism, by which basic fibroblast growth factor (FGF2) induces expression of fucosyltransferase 8 (FUT8) to increase core fucosylations of N-linked glycans of membrane-associated proteins, including several integrin subunits. n-linked glycans 170-186 fibroblast growth factor 2 Homo sapiens 80-84 29983388-2 2018 We have found an unexplored mechanism, by which basic fibroblast growth factor (FGF2) induces expression of fucosyltransferase 8 (FUT8) to increase core fucosylations of N-linked glycans of membrane-associated proteins, including several integrin subunits. n-linked glycans 170-186 fucosyltransferase 8 Homo sapiens 108-128 29983388-2 2018 We have found an unexplored mechanism, by which basic fibroblast growth factor (FGF2) induces expression of fucosyltransferase 8 (FUT8) to increase core fucosylations of N-linked glycans of membrane-associated proteins, including several integrin subunits. n-linked glycans 170-186 fucosyltransferase 8 Homo sapiens 130-134 30054538-9 2018 To test whether the microglial response is mediated by carbohydrate epitopes on PrPSc surface, the levels of sialylation of PrPSc N-linked glycans was altered by treatment of purified PrPSc with neuraminidase. n-linked glycans 130-146 prion protein Mus musculus 124-129 29575162-4 2018 N-linked glycans are first released from glycoproteins by enzymatic digestion, then labeled with fluorescence dyes for subsequent CE or LC separation, and LIF or MS detection. n-linked glycans 0-16 LIF interleukin 6 family cytokine Homo sapiens 155-158 29575162-8 2018 CONCLUSIONS: This on-line CE/LIF/MS method using Teal fluorescent dye and electrokinetic pump-based nanospray sheath liquid CE/MS coupling technology holds promise for on-line quantitation and identification of N-linked glycans on recombinant therapeutic proteins. n-linked glycans 212-228 LIF interleukin 6 family cytokine Homo sapiens 29-32 29858715-6 2018 PIP carries unusual highly fucosylated N-linked glycans with multiple Lewisy (Ley) epitopes on bi-, tri- and tetraantennary structures resulting in up to nine fucosyl residues on a tetraantennary glycan. n-linked glycans 39-55 prolactin induced protein Homo sapiens 0-3 29760474-0 2018 Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S. Endoglycosidase S (EndoS) is a bacterial endo-beta-N-acetylglucosaminidase that specifically catalyzes the hydrolysis of the beta-1,4 linkage between the first two N-acetylglucosamine residues of the biantennary complex-type N-linked glycans of IgG Fc regions. n-linked glycans 310-326 O-GlcNAcase Homo sapiens 131-159 29579062-11 2018 Overall, our data demonstrate that HIV-1 isolates display differential sensitivity to lectins, in part due to the microheterogeneity of N-linked glycans expressed on the surface of the virus Env glycoprotein. n-linked glycans 136-152 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 191-194 29273674-0 2018 Alternative routes for synthesis of N-linked glycans by Alg2 mannosyltransferase. n-linked glycans 36-52 GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase Saccharomyces cerevisiae S288C 56-60 29706962-1 2018 Immunoglobulin G (IgG) can contain N-linked glycans in the variable domains, the so-called Fab glycans, in addition to the Fc glycans in the CH2 domains. n-linked glycans 35-51 FA complementation group B Homo sapiens 91-94 29187368-0 2018 N-linked glycans are required on epithelial Na+ channel subunits for maturation and surface expression. n-linked glycans 0-16 sodium channel epithelial 1 subunit gamma Rattus norvegicus 33-55 29548671-3 2018 The crystal structure of the antigen-binding fragment of VRC-PG05 in complex with gp120 revealed an epitope comprised primarily of N-linked glycans from N262, N295, and N448 at the silent face center. n-linked glycans 131-147 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 82-87 29187368-4 2018 Heterologous expression in Xenopus oocytes or Fischer rat thyroid cells with alphabetagamma-ENaC lacking N-linked glycans on a single subunit reduced ENaC activity as well as the inhibitory response to extracellular Na+. n-linked glycans 105-121 sodium channel epithelial 1 subunit gamma Rattus norvegicus 92-96 29187368-4 2018 Heterologous expression in Xenopus oocytes or Fischer rat thyroid cells with alphabetagamma-ENaC lacking N-linked glycans on a single subunit reduced ENaC activity as well as the inhibitory response to extracellular Na+. n-linked glycans 105-121 sodium channel epithelial 1 subunit gamma Rattus norvegicus 150-154 28632942-1 2017 N-linked glycans such as 234 and 276 gp120 glycans are vital components of HIV evasion from humoral immunity and important for HIV-1 neutralization of many broadly neutralizing antibodies (bNAbs). n-linked glycans 0-16 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 37-42 29324290-2 2018 As MBL binds to carbohydrates, we hypothesized that N-linked glycans on the RRV envelope glycoproteins act as ligands for MBL. n-linked glycans 52-68 mannose binding lectin 2 Homo sapiens 3-6 29324290-2 2018 As MBL binds to carbohydrates, we hypothesized that N-linked glycans on the RRV envelope glycoproteins act as ligands for MBL. n-linked glycans 52-68 mannose binding lectin 2 Homo sapiens 122-125 29324290-3 2018 Using a panel of RRV mutants lacking the envelope N-linked glycans, we found that MBL deposition onto infected cells was dependent on the E2 glycans. n-linked glycans 50-66 mannose binding lectin 2 Homo sapiens 82-85 29324290-6 2018 These results demonstrate that the viral N-linked glycans promote MBL deposition and complement activation onto RRV-infected cells, contributing to the development of RRV-induced myositis. n-linked glycans 41-57 mannose binding lectin 2 Homo sapiens 66-69 28472687-5 2017 Glycan array analysis of DBL revealed its affinity toward high mannose N-linked glycans with enhanced affinity for terminal mannose including N-linked glycans of HIV envelope glycoprotein gp120 and has strong anti-reverse transcriptase activity. n-linked glycans 71-87 MCF.2 cell line derived transforming sequence Homo sapiens 25-28 28803068-4 2017 Hydrophilic Interaction Liquid Chromatography determined the structure of N-linked glycans present in HEK293-expressed hIFNgamma (hIFNgamma-HEK). n-linked glycans 74-90 interferon gamma Homo sapiens 119-128 28803068-4 2017 Hydrophilic Interaction Liquid Chromatography determined the structure of N-linked glycans present in HEK293-expressed hIFNgamma (hIFNgamma-HEK). n-linked glycans 74-90 interferon gamma Homo sapiens 130-139 28679530-1 2017 To study how the interaction between N-linked glycans and the surrounding amino acids influences oligosaccharide processing, we used protein disulfide isomerase (PDI), a glycoprotein bearing 5 N-glycosylation sites, as a model system and expressed it transiently in a Chinese hamster ovary (CHO)-S cell line. n-linked glycans 37-53 protein disulfide-isomerase Cricetulus griseus 162-165 28389847-8 2017 Our data provide pivotal information to distinguish between HBV-associated hepatitis, cirrhosis and HCC, and facilitate the discovery of biomarkers for HCC during its early stages based on precise alterations of N-linked glycans in saliva. n-linked glycans 212-228 HCC Homo sapiens 152-155 28160363-1 2017 Plant-produced glycoproteins contain N-linked glycans with plant-specific residues of beta(1,2)-xylose and core alpha(1,3)-fucose, which do not exist in mammalian-derived proteins. n-linked glycans 37-53 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 86-94 28364041-7 2017 Moreover, galectin-3 bound to N-linked glycans on CD146 and induced CD146 dimerization and subsequent activation of AKT signaling. n-linked glycans 30-46 galectin 3 Homo sapiens 10-20 28370891-6 2017 ADAMTS-13 contains 10 N-linked glycans, with four sites present in theTSP2 through to CUB domains that may contribute to its conformation. n-linked glycans 22-38 ADAM metallopeptidase with thrombospondin type 1 motif 13 Homo sapiens 0-9 28370891-15 2017 Immunoprecipitation experiments confirmed that loss of N-linked glycans in the CUB domains significantly reduced the interaction with the spacer domain and enhanced binding to the 6A6 anti-ADAMTS-13 antibody, which recognizes a cryptic epitope in the metalloprotease domain. n-linked glycans 55-71 ADAM metallopeptidase with thrombospondin type 1 motif 13 Homo sapiens 189-198 28370891-16 2017 Conclusions Together, these data demonstrate that the N-linked glycans of ADAMTS-13 play a crucial role in regulating ADAMTS-13 activity. n-linked glycans 54-70 ADAM metallopeptidase with thrombospondin type 1 motif 13 Homo sapiens 74-83 28370891-16 2017 Conclusions Together, these data demonstrate that the N-linked glycans of ADAMTS-13 play a crucial role in regulating ADAMTS-13 activity. n-linked glycans 54-70 ADAM metallopeptidase with thrombospondin type 1 motif 13 Homo sapiens 118-127 28424265-11 2017 Notably, N-linked glycans produced by GNE-deficient cells displayed enhanced binding to galectin-1, indicating that changes in GNE activity can alter affinity of cell-surface glycoproteins for the galectin lattice. n-linked glycans 9-25 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Homo sapiens 38-41 28424265-11 2017 Notably, N-linked glycans produced by GNE-deficient cells displayed enhanced binding to galectin-1, indicating that changes in GNE activity can alter affinity of cell-surface glycoproteins for the galectin lattice. n-linked glycans 9-25 galectin 1 Homo sapiens 88-98 28424265-11 2017 Notably, N-linked glycans produced by GNE-deficient cells displayed enhanced binding to galectin-1, indicating that changes in GNE activity can alter affinity of cell-surface glycoproteins for the galectin lattice. n-linked glycans 9-25 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Homo sapiens 127-130 28364041-7 2017 Moreover, galectin-3 bound to N-linked glycans on CD146 and induced CD146 dimerization and subsequent activation of AKT signaling. n-linked glycans 30-46 melanoma cell adhesion molecule Homo sapiens 50-55 28323990-9 2017 Results: We analyzed N-linked glycans and glycolipids in knockout TMEM165 HEK293 cells, revealing severe hypogalactosylation and GalNAc transfer defects. n-linked glycans 21-37 transmembrane protein 165 Homo sapiens 66-73 27888602-6 2017 Moreover, treatment with the alpha(1,3)-fucosyltransferase-FTVII also generated expression of HCELL on both BM-hMSCs and A-hMSCs, with sLeX decorations created on N-linked glycans of the "standard" CD44 (CD44s) isoform. n-linked glycans 163-179 fucosyltransferase 7 Homo sapiens 29-58 28207759-3 2017 Supplementing storage cells with lacking enzyme is accomplished via chronic intravenous administration of recombinant GBA containing mannose-terminated N-linked glycans, mediating the selective uptake by macrophages expressing mannose-binding lectin(s). n-linked glycans 152-168 glucosylceramidase beta Homo sapiens 118-121 28207759-3 2017 Supplementing storage cells with lacking enzyme is accomplished via chronic intravenous administration of recombinant GBA containing mannose-terminated N-linked glycans, mediating the selective uptake by macrophages expressing mannose-binding lectin(s). n-linked glycans 152-168 mannose binding lectin 2 Homo sapiens 227-249 28207759-4 2017 Two recombinant GBA preparations with distinct N-linked glycans are registered in Europe for treatment of type I GD: imiglucerase (Genzyme), contains predominantly Man(3) glycans, and velaglucerase (Shire PLC) Man(9) glycans. n-linked glycans 47-63 glucosylceramidase beta Homo sapiens 16-19 28031460-4 2017 We found that a gene encoding beta-galactoside alpha2,6-sialyltransferase-1 (St6gal1), a key enzyme responsible for the biosynthesis of alpha2,6-linked sialic acid in N-linked glycans, was most down-regulated in VATs from obese mice. n-linked glycans 167-183 beta galactoside alpha 2,6 sialyltransferase 1 Mus musculus 30-75 27956708-1 2017 Recently, we showed the unexpectedly high abundance of N-linked glycans on the Fab-domain of Anti-Citrullinated Protein Antibodies (ACPA). n-linked glycans 55-71 FA complementation group B Homo sapiens 79-82 28148964-5 2017 Mitochondrial PrPC was fully processed with mature N-linked glycans and did not require the GPI anchor for localization. n-linked glycans 51-67 prion protein Mus musculus 14-18 27490136-2 2017 Owing to their alpha-1,2 mannosidase activity, the EDEM1-3 proteins are able to process the N-linked glycans of misfolded or incompletely folded proteins, providing the recognition signal for their subsequent degradation. n-linked glycans 92-108 mannosidase alpha class 1A member 2 Homo sapiens 15-36 27490136-2 2017 Owing to their alpha-1,2 mannosidase activity, the EDEM1-3 proteins are able to process the N-linked glycans of misfolded or incompletely folded proteins, providing the recognition signal for their subsequent degradation. n-linked glycans 92-108 ER degradation enhancing alpha-mannosidase like protein 1 Homo sapiens 51-56 28031460-4 2017 We found that a gene encoding beta-galactoside alpha2,6-sialyltransferase-1 (St6gal1), a key enzyme responsible for the biosynthesis of alpha2,6-linked sialic acid in N-linked glycans, was most down-regulated in VATs from obese mice. n-linked glycans 167-183 beta galactoside alpha 2,6 sialyltransferase 1 Mus musculus 77-84 28031460-4 2017 We found that a gene encoding beta-galactoside alpha2,6-sialyltransferase-1 (St6gal1), a key enzyme responsible for the biosynthesis of alpha2,6-linked sialic acid in N-linked glycans, was most down-regulated in VATs from obese mice. n-linked glycans 167-183 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6 Mus musculus 47-55 27956708-1 2017 Recently, we showed the unexpectedly high abundance of N-linked glycans on the Fab-domain of Anti-Citrullinated Protein Antibodies (ACPA). n-linked glycans 55-71 proteinase 3 Homo sapiens 93-130 27956708-1 2017 Recently, we showed the unexpectedly high abundance of N-linked glycans on the Fab-domain of Anti-Citrullinated Protein Antibodies (ACPA). n-linked glycans 55-71 proteinase 3 Homo sapiens 132-136 27956708-2 2017 As N-linked glycans can mediate a variety of biological functions, we now aimed at investigating the structural composition of the Fab-glycans of ACPA-IgG to better understand their mediated biological effects. n-linked glycans 3-19 proteinase 3 Homo sapiens 146-150 27707925-1 2016 The HIV envelope glycoprotein (Env) is extensively modified with host-derived N-linked glycans. n-linked glycans 78-94 endogenous retrovirus group K member 20 Homo sapiens 8-29 27561202-1 2016 The hormone - specific FSHbeta subunit of the human FSH heterodimer consists of N-linked glycans at Asn7 and Asn24 residues that are co-translationally attached early during subunit biosynthesis. n-linked glycans 80-96 follicle stimulating hormone subunit beta Homo sapiens 23-30 27834568-6 2017 Removal of the Fab N-glycosylation site by single amino acid substitution, or removal of N-linked glycans by enzymatic digestion, drastically reduced the antibody"s ability to inhibit latency-associated peptide (LAP) and alphavbeta8 association, and TGF-beta activation in an alphavbeta8-mediated TGF-beta signaling reporter assay. n-linked glycans 89-105 transforming growth factor beta 1 Homo sapiens 184-210 27834568-6 2017 Removal of the Fab N-glycosylation site by single amino acid substitution, or removal of N-linked glycans by enzymatic digestion, drastically reduced the antibody"s ability to inhibit latency-associated peptide (LAP) and alphavbeta8 association, and TGF-beta activation in an alphavbeta8-mediated TGF-beta signaling reporter assay. n-linked glycans 89-105 transforming growth factor beta 1 Homo sapiens 212-215 27707925-1 2016 The HIV envelope glycoprotein (Env) is extensively modified with host-derived N-linked glycans. n-linked glycans 78-94 endogenous retrovirus group K member 20 Homo sapiens 31-34 27707925-11 2016 The HIV envelope glycoprotein (Env) is covered in an array of host-derived N-linked glycans often referred to as the glycan shield. n-linked glycans 75-91 endogenous retrovirus group K member 20 Homo sapiens 8-29 27707925-11 2016 The HIV envelope glycoprotein (Env) is covered in an array of host-derived N-linked glycans often referred to as the glycan shield. n-linked glycans 75-91 endogenous retrovirus group K member 20 Homo sapiens 31-34 27554083-0 2016 N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance. n-linked glycans 0-16 von Willebrand factor Homo sapiens 41-62 26960182-6 2016 Binding of Abs to epithelial cells was diminished following MUC16 knockdown, and the MUC16 N-linked glycans were critical for binding. n-linked glycans 91-107 mucin 16, cell surface associated Homo sapiens 85-90 27798151-5 2016 Unlike mammalian cell-derived NS1, which displays both high mannose and complex type N-linked glycans, soluble NS1 secreted from DENV-infected insect cells contains only high mannose glycans. n-linked glycans 85-101 influenza virus NS1A binding protein Homo sapiens 30-33 27554083-6 2016 Previous studies have demonstrated that the N-linked glycans within the A2 domain play an important role in modulating susceptibility to ADAMTS13 proteolysis. n-linked glycans 44-60 ADAM metallopeptidase with thrombospondin type 1 motif 13 Homo sapiens 137-145 27316967-7 2016 The findings indicate that the growth of S. gordonii DL1 in saliva depends to a significant extent on the sequential actions of first BgaA and then StrH and EndoD on N-linked glycans of PRG. n-linked glycans 166-182 Galactose-specific C-type lectin Drosophila melanogaster 53-56 27607237-3 2016 Here, we identified and characterized MoGls2 in Magnaporthe oryzae, which is a yeast glucosidase II homolog Gls2 and is required for trimming the final glucose in N-linked glycans and normal cell wall synthesis. n-linked glycans 163-179 glucan 1,3-alpha-glucosidase ROT2 Saccharomyces cerevisiae S288C 40-44 26829466-6 2016 Tsg has a high proportion of N-linked glycans, in relation to its molecular weight, which supports a role in solubilising BMPs. n-linked glycans 29-45 twisted gastrulation BMP signaling modulator 1 Homo sapiens 0-3 27489265-11 2016 IMPORTANCE: The HIV-1 Env glycoprotein presents a dense patchwork of host cell-derived N-linked glycans. n-linked glycans 87-103 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 22-25 27316967-12 2016 The results indicate that the growth of S. gordonii DL1 depends to a significant extent on sequential action of these cell surface GHs on N-linked glycans of basic proline-rich salivary glycoproteins, which appears to be an essential first step in salivary glycan foraging. n-linked glycans 138-154 Galactose-specific C-type lectin Drosophila melanogaster 52-55 27006333-1 2016 Whether the two N-linked glycans are important in prion, PrP, biology is unresolved. n-linked glycans 16-32 major prion protein Cricetulus griseus 57-60 27317661-1 2016 Prions or PrP(Sc) are proteinaceous infectious agents that consist of misfolded, self-replicating states of the prion protein or PrP(C) PrP(C) is posttranslationally modified with N-linked glycans and a sialylated glycosylphosphatidylinositol (GPI) anchor. n-linked glycans 180-196 prion protein Mus musculus 10-13 27281343-3 2016 We have previously reported that mature ABCC11 is a glycoprotein containing two N-linked glycans at Asn838 and Asn844. n-linked glycans 80-96 ATP binding cassette subfamily C member 11 Homo sapiens 40-46 27222580-9 2016 N-linked glycans and carbohydrate-binding molecular chaperones contribute to the efficient folding and secretion of functional ATIII. n-linked glycans 0-16 serpin family C member 1 Homo sapiens 127-132 26911932-11 2016 Our genetic approach provides direct in vivo evidence that N-linked glycans on FSHbeta subunit are essential for its efficient assembly with the alpha-subunit to form FSH heterodimer in pituitary. n-linked glycans 59-75 follicle stimulating hormone beta Mus musculus 79-86 27084007-3 2016 Recently, a cell wall-associated endo-beta-N-acetylglucosaminidase (EndoBI-1) found in various infant-borne bifidobacteria was shown to remove a range of intact N-linked glycans. n-linked glycans 161-177 O-GlcNAcase Homo sapiens 38-66 27013611-4 2016 Exoglycosidase removal of FVIII N-linked glycans significantly reduced binding to both Gal-1 and Gal-3. n-linked glycans 32-48 coagulation factor VIII Homo sapiens 26-31 27013611-4 2016 Exoglycosidase removal of FVIII N-linked glycans significantly reduced binding to both Gal-1 and Gal-3. n-linked glycans 32-48 galectin 1 Homo sapiens 87-92 27013611-4 2016 Exoglycosidase removal of FVIII N-linked glycans significantly reduced binding to both Gal-1 and Gal-3. n-linked glycans 32-48 galectin 3 Homo sapiens 97-102 26503547-1 2016 The acquisition of mannose 6-phosphate (Man6P) on N-linked glycans of lysosomal enzymes is a structural requirement for their transport from the Golgi apparatus to lysosomes mediated by the mannose 6-phosphate receptors, 300 kDa cation-independent mannose 6-phosphate receptor (MPR300) and 46 kDa cation-dependent mannose 6-phosphate receptor (MPR46). n-linked glycans 50-66 insulin like growth factor 2 receptor Homo sapiens 278-284 26773038-4 2016 We investigated how the N-linked glycans of the VWF A2 domain affect thermostability and regulate both the exposure of the ADAMTS13 binding sites and the scissile bond. n-linked glycans 24-40 von Willebrand factor Homo sapiens 48-51 26773038-4 2016 We investigated how the N-linked glycans of the VWF A2 domain affect thermostability and regulate both the exposure of the ADAMTS13 binding sites and the scissile bond. n-linked glycans 24-40 ADAM metallopeptidase with thrombospondin type 1 motif 13 Homo sapiens 123-131 26773038-5 2016 We show by differential scanning fluorimetry that the N-linked glycans thermodynamically stabilize the VWF A2 domain. n-linked glycans 54-70 von Willebrand factor Homo sapiens 103-106 26972002-1 2016 The HIV-1 envelope glycoprotein trimer is covered by an array of N-linked glycans that shield it from immune surveillance. n-linked glycans 65-81 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 10-31 26503547-1 2016 The acquisition of mannose 6-phosphate (Man6P) on N-linked glycans of lysosomal enzymes is a structural requirement for their transport from the Golgi apparatus to lysosomes mediated by the mannose 6-phosphate receptors, 300 kDa cation-independent mannose 6-phosphate receptor (MPR300) and 46 kDa cation-dependent mannose 6-phosphate receptor (MPR46). n-linked glycans 50-66 mannose-6-phosphate receptor, cation dependent Homo sapiens 297-342 26503547-1 2016 The acquisition of mannose 6-phosphate (Man6P) on N-linked glycans of lysosomal enzymes is a structural requirement for their transport from the Golgi apparatus to lysosomes mediated by the mannose 6-phosphate receptors, 300 kDa cation-independent mannose 6-phosphate receptor (MPR300) and 46 kDa cation-dependent mannose 6-phosphate receptor (MPR46). n-linked glycans 50-66 mannose-6-phosphate receptor, cation dependent Homo sapiens 344-349 26630650-6 2015 Two complex N-linked glycans akin to honey bee hyaluronidase glycosylations, were identified by tandem mass spectrometry. n-linked glycans 12-28 hyaluronidase Apis mellifera 47-60 26411545-2 2015 HIV Env is one of the most heavily glycosylated proteins known, with approximately half of its mass consisting of host-derived N-linked glycans. n-linked glycans 127-143 endogenous retrovirus group K member 20 Homo sapiens 4-7 26039217-10 2015 These data identify roles for ankyrin domain-4, cell surface N-linked glycans, and selected pore-loop domain residues in the activation of TRPA1 by insoluble particles. n-linked glycans 61-77 transient receptor potential cation channel subfamily A member 1 Homo sapiens 139-144 26296369-5 2015 In agreement, the glycomics analysis determines the glycosylation site and the N-glycan composition of CD69, and terminal removal of sialic acid from that N-linked glycans reverses the generation of forkhead box P3-positive Treg cells (23.21%; P < 0.05). n-linked glycans 155-171 CD69 molecule Homo sapiens 103-107 26085151-1 2015 UNLABELLED: The gp120/gp41 HIV-1 envelope glycoprotein (Env) is highly glycosylated, with up to 50% of its mass consisting of N-linked glycans. n-linked glycans 126-142 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 16-21 25630622-1 2015 PURPOSE: beta1,6-N-acetylglucosaminyltransferase V (MGAT5), which is required for the biosynthesis of beta1,6GlcNAc-branched N-linked glycans attached to cell surface and secreted glycoproteins, accounts for oncogenic growth signal transduction during the development and progression of various malignancies. n-linked glycans 125-141 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B Homo sapiens 9-50 25630622-1 2015 PURPOSE: beta1,6-N-acetylglucosaminyltransferase V (MGAT5), which is required for the biosynthesis of beta1,6GlcNAc-branched N-linked glycans attached to cell surface and secreted glycoproteins, accounts for oncogenic growth signal transduction during the development and progression of various malignancies. n-linked glycans 125-141 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Homo sapiens 52-57 26277072-1 2015 The glycan shield on the human immunodeficiency virus 1 (HIV-1) envelope (Env) glycoprotein has drawn attention as a target for HIV-1 vaccine design given that an increasing number of potent and broadly neutralizing antibodies (bNAbs) recognize epitopes entirely or partially comprised of high mannose type N-linked glycans. n-linked glycans 307-323 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 74-77 26203194-3 2015 The two N-linked glycans and the C-terminal domain that attach the core protein to the cell membrane are not resolved in the Gpc1 crystal structure. n-linked glycans 8-24 glypican 1 Homo sapiens 125-129 26148749-0 2015 Lectins as probes for assessing the accessibility of N-linked glycans in relation to the conformational changes of fibronectin. n-linked glycans 53-69 fibronectin 1 Homo sapiens 115-126 26085151-1 2015 UNLABELLED: The gp120/gp41 HIV-1 envelope glycoprotein (Env) is highly glycosylated, with up to 50% of its mass consisting of N-linked glycans. n-linked glycans 126-142 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 33-54 26085151-1 2015 UNLABELLED: The gp120/gp41 HIV-1 envelope glycoprotein (Env) is highly glycosylated, with up to 50% of its mass consisting of N-linked glycans. n-linked glycans 126-142 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 56-59 26085151-11 2015 Increasingly, HIV bnAbs are being identified that bind to the N-linked glycans coating the HIV envelope glycoproteins gp120 and gp41, highlighting them as important targets for vaccine design. n-linked glycans 62-78 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 118-123 26271046-3 2015 To date, a unique trisaccharide (HSO3-3GlcAbeta1-3Galbeta1-4GlcNAc), human natural killer-1 (HNK-1) carbohydrate, was found expressed specifically on N-linked glycans of GluA2 and regulated the cell surface expression of AMPAR and the spine maturation process. n-linked glycans 150-166 beta-1,3-glucuronyltransferase 1 Homo sapiens 93-98 26291458-7 2015 Smo proteins in Drosophila and vertebrate systems harbor N-linked glycans, but their role in Smo signaling has not been established. n-linked glycans 57-73 smoothened Drosophila melanogaster 0-3 26291458-8 2015 Herein, we present a comprehensive analysis of Drosophila and murine Smo glycosylation that supports a functional divergence in the contribution of N-linked glycans to signaling. n-linked glycans 148-164 smoothened, frizzled class receptor Mus musculus 69-72 25995448-3 2015 The C-type carbohydrate recognition domain in the extracellular portion of BDCA-2 contains a signature motif typical of C-type animal lectins that bind mannose, glucose, or GlcNAc, yet it has been reported that BDCA-2 binds selectively to galactose-terminated, biantennary N-linked glycans. n-linked glycans 273-289 C-type lectin domain family 4 member C Homo sapiens 75-81 25995448-3 2015 The C-type carbohydrate recognition domain in the extracellular portion of BDCA-2 contains a signature motif typical of C-type animal lectins that bind mannose, glucose, or GlcNAc, yet it has been reported that BDCA-2 binds selectively to galactose-terminated, biantennary N-linked glycans. n-linked glycans 273-289 C-type lectin domain family 4 member C Homo sapiens 211-217 25827571-9 2015 Importantly, most of the novel Sppl3 substrates catalyze the modification of N-linked glycans. n-linked glycans 77-93 signal peptide peptidase like 3 Homo sapiens 31-36 26121645-1 2015 The HIV envelope glycoprotein gp120 contains nine disulphide bridges and is highly glycosylated, carrying on average 24 N-linked glycans. n-linked glycans 120-136 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 30-35 26121645-2 2015 Using a probability calculation, we here demonstrate that there is a co-localization of disulphide bridges and N-linked glycans in HIV-1 gp120, with a predominance of N-linked glycans in close proximity to disulphide bridges, at the C-terminal side of the involved cysteines. n-linked glycans 111-127 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 137-142 26121645-2 2015 Using a probability calculation, we here demonstrate that there is a co-localization of disulphide bridges and N-linked glycans in HIV-1 gp120, with a predominance of N-linked glycans in close proximity to disulphide bridges, at the C-terminal side of the involved cysteines. n-linked glycans 167-183 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 137-142 25546301-1 2015 The crystal structure of a fully glycosylated HIV-1 gp120 core in complex with CD4 receptor and Fab 17b at 4.5-A resolution reveals 9 of the 15 N-linked glycans of core gp120 to be partially ordered. n-linked glycans 144-160 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 52-57 25546301-1 2015 The crystal structure of a fully glycosylated HIV-1 gp120 core in complex with CD4 receptor and Fab 17b at 4.5-A resolution reveals 9 of the 15 N-linked glycans of core gp120 to be partially ordered. n-linked glycans 144-160 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 169-174 25293322-5 2015 Upon deglycosylation to remove N-linked glycans by PNGase F (but not Endo H), the MOPR became a dense and sharp band with Mr of ~43 kDa, close to the theoretical Mr of its deduced amino acid sequences. n-linked glycans 31-47 opioid receptor, mu 1 Mus musculus 82-86 25304981-4 2015 N-linked glycans in the IGF receptor, IGF1R, influence its presentation at the cell surface. n-linked glycans 0-16 insulin like growth factor 1 receptor Homo sapiens 38-43 25304981-7 2015 Decreased binding of Phaseolus vulgaris lectin and phytohaemagglutinin to IGF1R immunoprecipitated from treated explants demonstrated reduced levels of complex N-linked glycans. n-linked glycans 160-176 insulin like growth factor 1 receptor Homo sapiens 74-79 25499264-2 2014 The development of phenotypic resistance to CBAs by the virus is accompanied by the deletion of multiple N-linked glycans of the surface envelope glycoprotein gp120. n-linked glycans 105-121 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 159-164 24967714-1 2014 N-linked glycans covering the surface of the HIV-1 glycoprotein gp120 are of major importance for the correct folding of this glycoprotein. n-linked glycans 0-16 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 64-69 25658012-0 2014 Retraction notice to NKR-P1A protein, an activating receptor of rat natural killer cells, binds to the chitobiose core of uncompletely glycosylated N-linked glycans, and to linear chitooligomers [Biochem. n-linked glycans 148-164 killer cell lectin-like receptor subfamily B, member 1A Rattus norvegicus 21-28 25658013-0 2014 Retraction notice to RETRACTED: NKR-P1A protein, an activating receptor of rat natural killer cells, binds to the chitobiose core of uncompletely glycosylated N-linked glycans, and to linear chitooligomers [Biochem. n-linked glycans 159-175 killer cell lectin-like receptor subfamily B, member 1A Rattus norvegicus 32-39 24965454-2 2014 2G12 is a unique, domain-exchanged antibody that binds exclusively to conserved N-linked glycans that form the high-mannose patch on the gp120 outer domain centered on a glycan at position N332. n-linked glycans 80-96 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 137-142 24992528-9 2014 Essential elements of the glycan V3 supersite, embodied by as few as 3 N-linked glycans and ~ 25 Env residues, can be segregated into acceptor scaffolds away from the immune-evading capabilities of the rest of HIV-1 Env, thereby providing a means to focus the immune response on the scaffolded supersite. n-linked glycans 71-87 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 216-219 24934233-4 2014 Additionally, mouse interleukin-3 expressed by a recombinant BmNPV was normally secreted and modified with N-linked glycans in BmN-SFM cells. n-linked glycans 107-123 interleukin 3 Mus musculus 20-33 25014350-2 2014 Previous studies have demonstrated that the native GP5 glycoprotein is poorly immunogenic and not able to induce robust protective responses, probably due to the presence of a non-neutralizing decoy epitope and shielding N-linked glycans close to its neutralizing epitope. n-linked glycans 221-237 glycoprotein V platelet Homo sapiens 51-54 24884609-9 2014 Site N274 contained high-mannose N-linked glycans in both serum and recombinant ITIH4. n-linked glycans 33-49 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 80-85 24967714-2 2014 Of the, on average, 24 N-linked glycans present on gp120, the glycan at Asn260 was reported to be essential for the correct expression of gp120 and gp41 in the virus particle and deletion of the N260 glycan in gp120 heavily compromised virus infectivity. n-linked glycans 23-39 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 51-56 24303005-0 2013 The influence of N-linked glycans on the molecular dynamics of the HIV-1 gp120 V3 loop. n-linked glycans 17-33 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 73-78 24213971-0 2014 Co-expression of gamma2 subunits hinders processing of N-linked glycans attached to the N104 glycosylation sites of GABAA receptor beta2 subunits. n-linked glycans 55-71 tryptophanyl-tRNA synthetase 1 Homo sapiens 17-23 24213971-0 2014 Co-expression of gamma2 subunits hinders processing of N-linked glycans attached to the N104 glycosylation sites of GABAA receptor beta2 subunits. n-linked glycans 55-71 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 131-136 24336949-3 2014 In this study, we examined the role that N-linked glycans (NLG) play in the secretion of BMP-2. n-linked glycans 41-57 bone morphogenetic protein 2 Homo sapiens 89-94 24473128-0 2014 Comprehensive functional analysis of N-linked glycans on Ebola virus GP1. n-linked glycans 37-53 GTP binding protein 1 Mus musculus 69-72 24473128-8 2014 The effects of the loss of GP1 N-linked glycans on Ca(2+)-dependent (C-type) lectin (CLEC)-dependent transduction were complex, and the effect was unique for each of the CLECs tested. n-linked glycans 31-47 GTP binding protein 1 Mus musculus 27-30 24473128-11 2014 In total, our results provide evidence that the conserved N-linked glycans on the EBOV GP1 core protect GP from antibody neutralization despite the negative impact the glycans have on viral entry efficiency. n-linked glycans 58-74 GTP binding protein 1 Mus musculus 87-90 24628331-4 2014 A total of 14 unique N-linked glycans corresponding to 27 unique N-linked glycopeptides were characterized at three N-linked sites (Asn-86, -169, and -242) present in VTN. n-linked glycans 21-37 vitronectin Homo sapiens 167-170 24608122-3 2014 The identified endo-beta-N-acetylglucosaminidase EndoE has activity on the N-linked glycans of the human immunoglobulin G (IgG). n-linked glycans 75-91 O-GlcNAcase Homo sapiens 20-48 24357164-1 2014 Human glycodelin consists of 162 amino acid residues and two N-linked glycans at Asn(28) and Asn(63) . n-linked glycans 61-77 progestagen associated endometrial protein Homo sapiens 6-16 24282309-4 2013 The cystine knot of Spz binds the concave face of the Toll leucine-rich repeat solenoid in an area delineated by N-linked glycans and induces a conformational change. n-linked glycans 113-129 spatzle Drosophila melanogaster 20-23 24282309-4 2013 The cystine knot of Spz binds the concave face of the Toll leucine-rich repeat solenoid in an area delineated by N-linked glycans and induces a conformational change. n-linked glycans 113-129 Toll Drosophila melanogaster 54-58 24115046-4 2013 Almost all of the N-linked glycans in human LCAT are fucosylated and sialylated. n-linked glycans 18-34 lecithin-cholesterol acyltransferase Homo sapiens 44-48 24224757-2 2013 Interactions of SP-D with highly branched viral N-linked glycans on hemagglutinin (HA), an abundant IAV envelope protein and critical virulence factor, promote viral aggregation and neutralization through as yet unknown molecular mechanisms. n-linked glycans 48-64 surfactant protein D Homo sapiens 16-20 24303005-1 2013 N-linked glycans attached to specific amino acids of the gp120 envelope trimer of a HIV virion can modulate the binding affinity of gp120 to CD4, influence coreceptor tropism, and play an important role in neutralising antibody responses. n-linked glycans 0-16 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 57-62 24303005-1 2013 N-linked glycans attached to specific amino acids of the gp120 envelope trimer of a HIV virion can modulate the binding affinity of gp120 to CD4, influence coreceptor tropism, and play an important role in neutralising antibody responses. n-linked glycans 0-16 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 132-137 24303005-1 2013 N-linked glycans attached to specific amino acids of the gp120 envelope trimer of a HIV virion can modulate the binding affinity of gp120 to CD4, influence coreceptor tropism, and play an important role in neutralising antibody responses. n-linked glycans 0-16 CD4 molecule Homo sapiens 141-144 24303005-3 2013 Here, we use a computational approach to determine the influence of N-linked glycans on the dynamics of the HIV-1 gp120 protein and, in particular, the V3 loop. n-linked glycans 68-84 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 114-119 24010128-8 2013 The proposed derivatization technique is successfully applied to the profiling of N-linked glycans derived from chicken ovalbumin. n-linked glycans 82-98 ovalbumin (SERPINB14) Gallus gallus 120-129 24036269-2 2013 However, factor IX (FIX) variants with additional N-linked glycans ("HG" variants) that were expressed in HKB11 cells showed increased clearance in rat in vivo pharmacokinetic studies relative to FIX variants with no additional glycans. n-linked glycans 50-66 coagulation factor IX Homo sapiens 9-18 24130780-1 2013 Fucosyltransferase 8 (FUT8) catalyzes the transfer of alpha1,6-linked fucose to the first N-acetylglucosamine in N-linked glycans (core fucosylation). n-linked glycans 113-129 fucosyltransferase 8 Homo sapiens 0-20 24130780-1 2013 Fucosyltransferase 8 (FUT8) catalyzes the transfer of alpha1,6-linked fucose to the first N-acetylglucosamine in N-linked glycans (core fucosylation). n-linked glycans 113-129 fucosyltransferase 8 Homo sapiens 22-26 24033743-7 2013 GGTA1/CMAH knockout pig samples had increased relative amounts of high-mannose, incomplete, and xylosylated N-linked glycans. n-linked glycans 108-124 N-acetyllactosaminide alpha-1,3-galactosyltransferase Sus scrofa 0-5 23852824-9 2013 FV and FVIII likely bind LMAN1 through the high-mannose N-linked glycans under the higher Ca2+ conditions in the ER and dissociate in the lower Ca2+ environment of the ER-Golgi intermediate compartment. n-linked glycans 56-72 coagulation factor VIII Homo sapiens 7-12 23852824-9 2013 FV and FVIII likely bind LMAN1 through the high-mannose N-linked glycans under the higher Ca2+ conditions in the ER and dissociate in the lower Ca2+ environment of the ER-Golgi intermediate compartment. n-linked glycans 56-72 lectin, mannose binding 1 Homo sapiens 25-30 23738536-5 2013 BTN was concentrated in the apical membrane in all species examined and contained mature N-linked glycans. n-linked glycans 89-105 butyrophilin, subfamily 1, member A1 Mus musculus 0-3 24033743-7 2013 GGTA1/CMAH knockout pig samples had increased relative amounts of high-mannose, incomplete, and xylosylated N-linked glycans. n-linked glycans 108-124 cytidine monophospho-N-acetylneuraminic acid hydroxylase Sus scrofa 6-10 22610315-6 2012 The interaction between ganglioside GM3, and multi (>3) GlcNAc termini of N-linked glycans of epidermal growth factor receptor (EGFR), has been indicated as the molecular mechanism for the inhibitory effect of GM3 on EGFR activation. n-linked glycans 77-93 granulocyte macrophage antigen 3 Mus musculus 36-39 23536670-1 2013 Griffithsin, which binds N-linked glycans on gp120 to prevent HIV entry, has the most potent HIV-1 inhibitory activity described for any antiviral lectin and is being developed for topical preexposure prophylaxis. n-linked glycans 25-41 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 45-50 23274891-2 2013 We hypothesized that loss-of-function HNF1A mutations causal for maturity-onset diabetes of the young (MODY) would display altered fucosylation of N-linked glycans on plasma proteins and that glycan biomarkers could improve the efficiency of a diagnosis of HNF1A-MODY. n-linked glycans 147-163 HNF1 homeobox A Homo sapiens 38-43 22544341-3 2013 We analysed the N-linked glycans of L1CAM from different stages of melanoma progression, using high-performance liquid chromatography combined with exoglycosidase sequencing, matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry, and lectin probes. n-linked glycans 16-32 L1 cell adhesion molecule Homo sapiens 36-41 23777450-10 2013 Here, we present data for the N-linked glycans present on FcgammaRs produced in NS0 cells, namely, FcgammaRIa, FcgammaRIIa, FcgammaRIIB, FcgammaRIIIa, and FcgammaRIIIb. n-linked glycans 30-46 Fc receptor, IgG, low affinity IIb Mus musculus 124-135 23416198-2 2013 The immunosuppressive effects of IVIg are, in part, attributed to terminal alpha2,6-linked sialic acid residues on the N-linked glycans of the IgG Fc (fragment crystallizable) domain. n-linked glycans 119-135 immunoglobulin heavy variable V1-62 Mus musculus 143-146 22610315-6 2012 The interaction between ganglioside GM3, and multi (>3) GlcNAc termini of N-linked glycans of epidermal growth factor receptor (EGFR), has been indicated as the molecular mechanism for the inhibitory effect of GM3 on EGFR activation. n-linked glycans 77-93 epidermal growth factor receptor Mus musculus 97-129 22610315-6 2012 The interaction between ganglioside GM3, and multi (>3) GlcNAc termini of N-linked glycans of epidermal growth factor receptor (EGFR), has been indicated as the molecular mechanism for the inhibitory effect of GM3 on EGFR activation. n-linked glycans 77-93 epidermal growth factor receptor Mus musculus 131-135 22610315-6 2012 The interaction between ganglioside GM3, and multi (>3) GlcNAc termini of N-linked glycans of epidermal growth factor receptor (EGFR), has been indicated as the molecular mechanism for the inhibitory effect of GM3 on EGFR activation. n-linked glycans 77-93 granulocyte macrophage antigen 3 Mus musculus 213-216 22610315-6 2012 The interaction between ganglioside GM3, and multi (>3) GlcNAc termini of N-linked glycans of epidermal growth factor receptor (EGFR), has been indicated as the molecular mechanism for the inhibitory effect of GM3 on EGFR activation. n-linked glycans 77-93 epidermal growth factor receptor Mus musculus 220-224 22722937-0 2012 Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4. n-linked glycans 74-90 beta-1,4-N-acetyl-galactosaminyltransferase 3 Homo sapiens 119-179 22855528-0 2012 Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9-dependent mechanism. n-linked glycans 15-31 CD164 molecule Rattus norvegicus 60-67 22855528-0 2012 Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9-dependent mechanism. n-linked glycans 15-31 galectin-9 Canis lupus familiaris 88-98 22715095-4 2012 A paralog of GnT-Vb, N-acetylglucosaminyltransferase (GnT-V), is expressed in many tissues and brain, synthesizing N-linked, beta1,6-branched glycans, but its ability to synthesize O-mannosyl-branched glycans is unknown; conversely, although GnT-Vb can synthesize N-linked glycans in vitro, its contribution to their synthesis in vivo is unknown. n-linked glycans 264-280 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B Homo sapiens 13-19 22715095-4 2012 A paralog of GnT-Vb, N-acetylglucosaminyltransferase (GnT-V), is expressed in many tissues and brain, synthesizing N-linked, beta1,6-branched glycans, but its ability to synthesize O-mannosyl-branched glycans is unknown; conversely, although GnT-Vb can synthesize N-linked glycans in vitro, its contribution to their synthesis in vivo is unknown. n-linked glycans 264-280 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Homo sapiens 13-18 22715095-4 2012 A paralog of GnT-Vb, N-acetylglucosaminyltransferase (GnT-V), is expressed in many tissues and brain, synthesizing N-linked, beta1,6-branched glycans, but its ability to synthesize O-mannosyl-branched glycans is unknown; conversely, although GnT-Vb can synthesize N-linked glycans in vitro, its contribution to their synthesis in vivo is unknown. n-linked glycans 264-280 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B Homo sapiens 242-248 23023295-5 2012 Moreover, it became evident that the type of linkage of Sia on N-linked glycans was dramatically changed from alpha-2-3 to alpha-2-6, and the expression of alpha-1-2 fucose and type 1 LacNAc structures became clearly apparent, while no such glycan epitopes were detected in fibroblasts. n-linked glycans 63-79 immunoglobulin binding protein 1 Homo sapiens 123-132 22261557-5 2012 The lectin binding pattern indicates a massive presence of fucose alpha1,2 linked to galactose in O-glycans and smaller quantities of fucose linked alpha1,6 to N-acetylglucosamine in the core of N-linked glycans. n-linked glycans 195-211 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6 Mus musculus 148-156 22298023-6 2012 In contrast to O-linked glycans of ZP3 in mice, N-linked glycans of human ZP3 and ZP4 are more relevant for induction of the acrosome reaction. n-linked glycans 48-64 zona pellucida glycoprotein 3 Homo sapiens 74-77 22722937-0 2012 Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4. n-linked glycans 74-90 beta-1,4-N-acetyl-galactosaminyltransferase 4 Homo sapiens 185-199 22836271-7 2012 Moreover, the IGF-1-mediated mitogenic microglia response was reduced by N-glycosylation inhibitor tunicamycine while coimmunoprecipitation experiments revealed galectin-3 binding to IGF-receptor 1 (R1), thus suggesting that interaction of galectin-3 with the N-linked glycans of receptors for growth factors is involved in IGF-R1 signaling. n-linked glycans 260-276 insulin-like growth factor 1 Mus musculus 14-19 22836271-7 2012 Moreover, the IGF-1-mediated mitogenic microglia response was reduced by N-glycosylation inhibitor tunicamycine while coimmunoprecipitation experiments revealed galectin-3 binding to IGF-receptor 1 (R1), thus suggesting that interaction of galectin-3 with the N-linked glycans of receptors for growth factors is involved in IGF-R1 signaling. n-linked glycans 260-276 lectin, galactose binding, soluble 3 Mus musculus 161-171 22891160-8 2012 Further improvement of V3 immunogenicity is attainable by forming immune complexes with gp120 mutants lacking site-specific N-linked glycans. n-linked glycans 124-140 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 88-93 22443713-5 2012 The structural model of AtDIR6 was supported experimentally by confirmation of a predicted disulfide bridge and by the characterization of two N-linked glycans at the solvent-exposed protein surface. n-linked glycans 143-159 Disease resistance-responsive (dirigent-like protein) family protein Arabidopsis thaliana 24-30 22505413-3 2012 Human p19 and p40 subunits were cloned and coexpressed in N-acetylglucosaminyltransferase I-negative 293S cells, which produce high-mannose-type glycosylated proteins in order to diminish the heterogeneity of modified N-linked glycans. n-linked glycans 218-234 interleukin 23 subunit alpha Homo sapiens 6-9 22505413-3 2012 Human p19 and p40 subunits were cloned and coexpressed in N-acetylglucosaminyltransferase I-negative 293S cells, which produce high-mannose-type glycosylated proteins in order to diminish the heterogeneity of modified N-linked glycans. n-linked glycans 218-234 interleukin 9 Homo sapiens 14-17 22267483-6 2012 Binding studies using purified proteins confirmed that VWF could directly interact with both galectins, predominantly via its N-linked glycans. n-linked glycans 126-142 Von Willebrand factor Mus musculus 55-58 22645128-2 2012 N-Linked glycans, which constitute almost half of the molecular mass of the external Env domains, produce considerable structural heterogeneity and are a major impediment to crystallization studies. n-linked glycans 0-16 endogenous retrovirus group K member 20 Homo sapiens 85-88 22584580-1 2012 Porcine pancreatic alpha-amylase (PPA) binds to N-linked glycans of glycoproteins (Matsushita, H., Takenaka, M., and Ogawa, H. (2002) J. Biol Chem., 277, 4680-4686). n-linked glycans 48-64 amylase alpha 2A Homo sapiens 8-32 22628288-1 2012 The human immunodeficiency virus type-1 (HIV-1) is able to shield immunogenic peptide epitopes on its envelope spike (a trimer of two glycoproteins, gp120 and gp41) by presenting numerous host-derived N-linked glycans. n-linked glycans 201-217 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 149-154 22551306-9 2012 Moreover, PTx is able to activate signaling by binding either N-linked or O-linked glycan-modified receptors as the TCR displays N-linked glycans while CD8zeta displays O-linked glycans. n-linked glycans 129-145 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 116-119 22531441-1 2012 The presence or absence of core fucose in the Fc region N-linked glycans of antibodies affects their binding affinity toward FcgammaRIIIa as well as their antibody-dependent cell-mediated cytotoxicity (ADCC) activity. n-linked glycans 56-72 Fc gamma receptor IIIa Homo sapiens 125-137 21932778-9 2011 In summary, we have found that the potential N-glycosylation sites in glypican-1 are invariably occupied and that the N-linked glycans on glypican-1 affect protein expression and heparan sulfate substitution but that correct folding can be obtained in the absence of N-linked glycans. n-linked glycans 118-134 glypican 1 Homo sapiens 138-148 22792360-4 2012 In this study, we evaluated the effect of modifying N-linked glycans on recombinant human TPP1 on its pharmacokinetic properties after administration via tail vein injection to a mouse model of LINCL. n-linked glycans 52-68 tripeptidyl peptidase 1 Homo sapiens 90-94 22191536-0 2012 Analysis of folate binding protein N-linked glycans by mass spectrometry. n-linked glycans 35-51 folate receptor alpha Homo sapiens 12-34 22191536-8 2012 It was found that FBP from human milk contains putative structures that have composition consistent with high-mannose (Hex(5-6)HexNAc(2)) as well as hybrid and complex N-linked glycans (NeuAc(0-1)Fuc(0-3)Hex(3-6)HexNAc(3-5)). n-linked glycans 168-184 folate receptor alpha Homo sapiens 18-21 22191536-9 2012 The FBP from bovine milk contains putative structures corresponding to high-mannose (Hex(4-9)HexNAc(2)) as well as hybrid and complex N-linked glycans (Hex(3-6)HexNAc(3-6)), but these glycans mostly do not contain fucose and sialic acid. n-linked glycans 134-150 folate receptor alpha Bos taurus 4-7 22438913-10 2012 In particular, mass spectrometry showed that IGF1R had N-linked glycans at N913 in three figitumumab-sensitive cell lines. n-linked glycans 55-71 insulin-like growth factor I receptor Mus musculus 45-50 22093069-4 2011 EF2863 hydrolyzes the glycosidic bond between two N-acetylglucosamines (GlcNAc) in N-linked glycans of the high-mannose and hybrid type, releasing the glycan and leaving one GlcNAc attached to the protein. n-linked glycans 83-99 chitinase Enterococcus faecalis V583 0-6 21932778-0 2011 The structural role of N-linked glycans on human glypican-1. n-linked glycans 23-39 glypican 1 Homo sapiens 49-59 21932778-9 2011 In summary, we have found that the potential N-glycosylation sites in glypican-1 are invariably occupied and that the N-linked glycans on glypican-1 affect protein expression and heparan sulfate substitution but that correct folding can be obtained in the absence of N-linked glycans. n-linked glycans 267-283 glypican 1 Homo sapiens 70-80 21932778-9 2011 In summary, we have found that the potential N-glycosylation sites in glypican-1 are invariably occupied and that the N-linked glycans on glypican-1 affect protein expression and heparan sulfate substitution but that correct folding can be obtained in the absence of N-linked glycans. n-linked glycans 267-283 glypican 1 Homo sapiens 138-148 21880749-5 2011 We show here that galectin-1 directly binds to HIV-1 in a beta-galactoside-dependent fashion through recognition of clusters of N-linked glycans on the viral envelope gp120. n-linked glycans 128-144 galectin 1 Homo sapiens 18-28 21957147-4 2011 The interaction of DCs with HIV-1 involves C-type lectin receptors, such as DC-specific ICAM-3-grabbing nonintegrin, which bind to the envelope glycoprotein complex (Env), which is decorated heavily with N-linked glycans. n-linked glycans 204-220 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 166-169 21880749-5 2011 We show here that galectin-1 directly binds to HIV-1 in a beta-galactoside-dependent fashion through recognition of clusters of N-linked glycans on the viral envelope gp120. n-linked glycans 128-144 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 167-172 21697506-5 2011 Partial redistribution of the modified ERManI was observed along with an accelerated rate at which N-linked glycans of misfolded alpha1-antitrypsin variant NHK were trimmed. n-linked glycans 99-115 serpin family A member 1 Homo sapiens 129-147 21203834-1 2011 We investigated interaction of GM3 with N-acetylglucosamine (GlcNAc) termini of N-linked glycans of epidermal growth factor receptor (EGFR), as the underlying mechanism for inhibitory effect of GM3 on EGFR activation, using ldlD cells transfected with EGFR gene. n-linked glycans 80-96 Epidermal growth factor receptor Drosophila melanogaster 100-132 21203834-1 2011 We investigated interaction of GM3 with N-acetylglucosamine (GlcNAc) termini of N-linked glycans of epidermal growth factor receptor (EGFR), as the underlying mechanism for inhibitory effect of GM3 on EGFR activation, using ldlD cells transfected with EGFR gene. n-linked glycans 80-96 Epidermal growth factor receptor Drosophila melanogaster 134-138 21715597-0 2011 Removal of two high-mannose N-linked glycans on gp120 renders human immunodeficiency virus 1 largely resistant to the carbohydrate-binding agent griffithsin. n-linked glycans 28-44 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 48-53 21220208-1 2011 Human CMP-N-acetylneuraminic acid (NeuAc) synthase (hCSS) and alpha2,6-sialyltransferase (hST) participate in the sialylation of N-linked glycans in mammalian cells. n-linked glycans 129-145 cytidine monophosphate N-acetylneuraminic acid synthetase Homo sapiens 6-50 21217149-1 2011 Cytoplasmic alpha-mannosidase (Man2C1) has been implicated in non-lysosomal catabolism of free oligosaccharides derived from N-linked glycans accumulated in the cytosol. n-linked glycans 125-141 mannosidase alpha class 2C member 1 Homo sapiens 31-37 21689651-3 2011 TMEM114 and TMEM235 differed from claudins in terms of localisation in polarised epithelial cells and by the presence of N-linked glycans. n-linked glycans 121-137 transmembrane protein 114 Xenopus tropicalis 0-7 21220208-1 2011 Human CMP-N-acetylneuraminic acid (NeuAc) synthase (hCSS) and alpha2,6-sialyltransferase (hST) participate in the sialylation of N-linked glycans in mammalian cells. n-linked glycans 129-145 sulfotransferase family 2A member 1 Homo sapiens 90-93 21220208-2 2011 hCSS synthesizes CMP-NeuAc, which hST uses as a donor substrate to transfer NeuAc to the terminal position of N-linked glycans. n-linked glycans 110-126 sulfotransferase family 2A member 1 Homo sapiens 34-37 21220208-9 2011 Here, we demonstrate that the in vitro sialylation of N-linked glycans on mammalian proteins can be achieved using plant cell extracts stably expressing hCSS and hST, providing proof-of-principle that a sialylated human therapeutic protein can be produced in plants. n-linked glycans 54-70 sulfotransferase family 2A member 1 Homo sapiens 162-165 21173156-4 2011 ST6Gal-I adds an alpha2,6-linked sialic acid to the terminal galactose of N-linked glycans, and this modification blocks galectin binding to beta-galactosides. n-linked glycans 74-90 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 Homo sapiens 0-8 21104290-4 2011 The present review addresses molecular aspects related to E-cadherin N-glycosylation and evidence is presented showing that the modification of N-linked glycans on E-cadherin can affect the adhesive function of this adhesion molecule. n-linked glycans 144-160 cadherin 1 Homo sapiens 58-68 21104290-4 2011 The present review addresses molecular aspects related to E-cadherin N-glycosylation and evidence is presented showing that the modification of N-linked glycans on E-cadherin can affect the adhesive function of this adhesion molecule. n-linked glycans 144-160 cadherin 1 Homo sapiens 164-174 21030537-3 2011 In this study, a detailed structure analysis of the N-linked glycans from total glycoproteins from the SKOV3 ovarian carcinoma cell line and from a recombinantly expressed secretory glycoprotein, erythropoietin (EPO), produced from the same cells has been performed using high-performance anion exchange chromatography with pulsed amperometric detection and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. n-linked glycans 52-68 erythropoietin Homo sapiens 196-210 21030537-3 2011 In this study, a detailed structure analysis of the N-linked glycans from total glycoproteins from the SKOV3 ovarian carcinoma cell line and from a recombinantly expressed secretory glycoprotein, erythropoietin (EPO), produced from the same cells has been performed using high-performance anion exchange chromatography with pulsed amperometric detection and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. n-linked glycans 52-68 erythropoietin Homo sapiens 212-215 21044954-2 2011 In this study, the role of N-linked glycans in modulating APC endothelial cytoprotective signaling via endothelial cell protein C receptor/protease-activated receptor 1 (PAR1) was investigated. n-linked glycans 27-43 coagulation factor II thrombin receptor Homo sapiens 170-174 21044954-3 2011 Enzymatic digestion of APC N-linked glycans (PNG-APC) decreased the APC concentration required to achieve half-maximal inhibition of thrombin-induced endothelial cell barrier permeability by 6-fold. n-linked glycans 27-43 coagulation factor II, thrombin Homo sapiens 133-141 21042299-7 2011 However, N-linked glycans of human ZP1, ZP3 and ZP4 have important roles in the induction of the AR. n-linked glycans 9-25 zona pellucida glycoprotein 1 Homo sapiens 35-38 21042299-7 2011 However, N-linked glycans of human ZP1, ZP3 and ZP4 have important roles in the induction of the AR. n-linked glycans 9-25 zona pellucida glycoprotein 4 Homo sapiens 48-51 20709295-3 2010 Mannose-binding lectin (MBL) recognized N-linked glycans on the structural proteins of WNV and Dengue virus (DENV), resulting in neutralization through a C3- and C4-dependent mechanism that utilized both the canonical and bypass lectin activation pathways. n-linked glycans 40-56 mannose binding lectin 2 Homo sapiens 0-22 21179548-7 2010 Like its parent protein, GRFN-1 bound viral glycoproteins gp41 and gp120 via the N-linked glycans on their surface. n-linked glycans 81-97 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 67-72 21218342-7 2011 Biochemical and mass spectrometry analyses in combination with the generation of bovine clusterin subunit-specific antibodies enabled us to demonstrate that it was beta-subunits of clusterin possessing N-linked glycans of complex structure that exhibited differential abundance in response to BSE infection. n-linked glycans 202-218 clusterin Bos taurus 181-190 20709295-3 2010 Mannose-binding lectin (MBL) recognized N-linked glycans on the structural proteins of WNV and Dengue virus (DENV), resulting in neutralization through a C3- and C4-dependent mechanism that utilized both the canonical and bypass lectin activation pathways. n-linked glycans 40-56 mannose binding lectin 2 Homo sapiens 24-27 20709295-6 2010 Experiments in mice showed an MBL-dependent accelerated intravascular clearance of DENV or a WNV mutant with two N-linked glycans on its E protein, but not with wild-type WNV. n-linked glycans 113-129 mannose-binding lectin (protein C) 2 Mus musculus 30-33 20418283-1 2010 We examined the role that N-linked glycans play in the synthesis and expression of von Willebrand Factor (VWF). n-linked glycans 26-42 von Willebrand factor Homo sapiens 83-104 20418283-1 2010 We examined the role that N-linked glycans play in the synthesis and expression of von Willebrand Factor (VWF). n-linked glycans 26-42 von Willebrand factor Homo sapiens 106-109 20418283-2 2010 Blocking the addition of N-linked glycans (NLGs) or inhibiting initial glycan processing prevented secretion of VWF. n-linked glycans 25-41 von Willebrand factor Homo sapiens 112-115 20418283-9 2010 These data provide further evidence of the critical role that individual N-linked glycans play in determining VWF synthesis and expression. n-linked glycans 73-89 von Willebrand factor Homo sapiens 110-113 20210927-2 2010 Expression of ABH antigens on N-linked glycans of VWF protects plasma VWF from proteolysis and clearance. n-linked glycans 30-46 alkB homolog 1, histone H2A dioxygenase Homo sapiens 14-17 20379804-3 2010 The terminal sialic acid in the N-linked glycans of FVIII is required for maximal circulatory half life. n-linked glycans 32-48 coagulation factor VIII Homo sapiens 52-57 20210927-2 2010 Expression of ABH antigens on N-linked glycans of VWF protects plasma VWF from proteolysis and clearance. n-linked glycans 30-46 von Willebrand factor Homo sapiens 50-53 20210927-2 2010 Expression of ABH antigens on N-linked glycans of VWF protects plasma VWF from proteolysis and clearance. n-linked glycans 30-46 von Willebrand factor Homo sapiens 70-73 19681908-7 2009 In addition, interleukin-6 production by human dendritic cells was enhanced by C. jejuni lacking N-linked glycans compared with wild-type bacteria. n-linked glycans 97-113 interleukin 6 Homo sapiens 13-26 20479940-1 2010 BACKGROUND: Peptide:N-glycanase (PNGase) is an enzyme which releases N-linked glycans from glycopeptides/glycoproteins. n-linked glycans 69-85 PNGase-like Drosophila melanogaster 12-31 20479940-1 2010 BACKGROUND: Peptide:N-glycanase (PNGase) is an enzyme which releases N-linked glycans from glycopeptides/glycoproteins. n-linked glycans 69-85 PNGase-like Drosophila melanogaster 33-39 20306342-5 2010 Interestingly, the lectin showed high affinity for glycans which are part of ovarian cancer marker CA125, a high molecular weight mucin containing high mannose and complex bisecting type N-linked glycans as well core 1 and 2 type O-glycans. n-linked glycans 187-203 LOC100508689 Homo sapiens 130-135 19884343-1 2010 Alpha-mannosidosis is caused by the genetic defect of the lysosomal alpha-d-mannosidase (LAMAN), which is involved in the breakdown of free alpha-linked mannose-containing oligosaccharides originating from glycoproteins with N-linked glycans, and thus manifests itself in an extensive storage of mannose-containing oligosaccharides. n-linked glycans 225-241 mannosidase 2, alpha B1 Mus musculus 89-94 19920089-1 2010 Design of an envelope glycoprotein (Env)-based vaccine against human immunodeficiency virus type-1 (HIV-1) is complicated by the large number of N-linked glycans that coat the protein and serve as a barrier to antibody-mediated neutralization. n-linked glycans 145-161 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 13-34 19920089-1 2010 Design of an envelope glycoprotein (Env)-based vaccine against human immunodeficiency virus type-1 (HIV-1) is complicated by the large number of N-linked glycans that coat the protein and serve as a barrier to antibody-mediated neutralization. n-linked glycans 145-161 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 36-39 19551866-8 2010 N-linked glycans of serum haptoglobin from colon cancer patients vs. healthy subjects were released by N-glycanase, fluorescence-labeled, and subjected to normal-phase high performance liquid chromatography (NP-HPLC). n-linked glycans 0-16 haptoglobin Homo sapiens 26-37 19542522-0 2009 A novel role for Gtb1p in glucose trimming of N-linked glycans. n-linked glycans 46-62 Gtb1p Saccharomyces cerevisiae S288C 17-22 19542522-2 2009 It trims the middle and innermost glucose residues (Glc2 and Glc1) from N-linked glycans. n-linked glycans 72-88 GTPase-activating protein IRA1 Saccharomyces cerevisiae S288C 61-65 19726492-6 2009 N-Linked glycans, released from plasma proteins, were separated using hydrophilic interaction high-performance liquid chromatography into 16 groups (GP1-GP16) and quantified. n-linked glycans 0-16 GTP binding protein 1 Homo sapiens 149-157 19683346-9 2009 We demonstrate that GdA selectively recognizes complex-type N-linked glycans on T cell surface glycoproteins, and propose that the galectin-1 glycoprotein receptor CD7 maybe a novel target for GdA on T cells. n-linked glycans 60-76 progestagen associated endometrial protein Homo sapiens 20-23 19690161-0 2009 Complex N-linked glycans on Asn-89 of Kaposi sarcoma herpes virus-encoded interleukin-6 mediate optimal function by affecting cytokine protein conformation. n-linked glycans 8-24 interleukin 6 Homo sapiens 74-87 19903263-5 2009 These findings suggest that CD63 interacts with CXCR4 through the N-linked glycans-portion of the CD63 protein and that the complex induces direction of CXCR4 trafficking to the endosomes/lysosomes, rather than to the plasma membrane. n-linked glycans 66-82 CD63 molecule Homo sapiens 28-32 19903263-5 2009 These findings suggest that CD63 interacts with CXCR4 through the N-linked glycans-portion of the CD63 protein and that the complex induces direction of CXCR4 trafficking to the endosomes/lysosomes, rather than to the plasma membrane. n-linked glycans 66-82 C-X-C motif chemokine receptor 4 Homo sapiens 48-53 19903263-5 2009 These findings suggest that CD63 interacts with CXCR4 through the N-linked glycans-portion of the CD63 protein and that the complex induces direction of CXCR4 trafficking to the endosomes/lysosomes, rather than to the plasma membrane. n-linked glycans 66-82 CD63 molecule Homo sapiens 98-102 19903263-5 2009 These findings suggest that CD63 interacts with CXCR4 through the N-linked glycans-portion of the CD63 protein and that the complex induces direction of CXCR4 trafficking to the endosomes/lysosomes, rather than to the plasma membrane. n-linked glycans 66-82 C-X-C motif chemokine receptor 4 Homo sapiens 153-158 19571171-2 2009 Here, we report the sites at which GlcNAc6ST-1 is modified with N-linked glycans and the effects that each glycan has on enzyme activity, specificity, and localization. n-linked glycans 64-80 carbohydrate sulfotransferase 2 Homo sapiens 35-46 19595807-5 2009 X-ray analysis has shown that each TLR3-ECD of a dimer binds dsRNA at two sites located at opposite ends of the TLR3 "horseshoe" on the one lateral face that lacks N-linked glycans. n-linked glycans 164-180 toll like receptor 3 Homo sapiens 35-39 19595807-5 2009 X-ray analysis has shown that each TLR3-ECD of a dimer binds dsRNA at two sites located at opposite ends of the TLR3 "horseshoe" on the one lateral face that lacks N-linked glycans. n-linked glycans 164-180 toll like receptor 3 Homo sapiens 112-116 19443639-6 2009 Bsg isolated from HL-60 cells bound to E-selectin, and tunicamycin treatment to abolish N-linked glycans from Bsg abrogated this binding. n-linked glycans 88-104 basigin (Ok blood group) Homo sapiens 0-3 19284292-3 2009 Distinct from these examples, the beta4-GalNAc modification of N-linked glycans on a selected panel of proteins, such as carbonic anhydrase or glycodelin, was demonstrated recently to require specific protein (sequence) determinants proximal to the glycosylation site that function as cis-regulatory elements. n-linked glycans 63-79 progestagen associated endometrial protein Homo sapiens 143-153 19415334-10 2009 Lung RAGE appeared to contain two N-linked glycans. n-linked glycans 34-50 advanced glycosylation end product-specific receptor Mus musculus 5-9 19465480-4 2009 Negative ion nano-electrospray ionization mass spectra of the 19A N-linked glycans from HEK 293T Lec36 and swainsonine-treated HEK 293T cells were qualitatively indistinguishable and, as shown by collision-induced dissociation spectra, were dominated by hybrid-type glycosylation. n-linked glycans 66-82 SLAM family member 7 Homo sapiens 62-65 19443639-6 2009 Bsg isolated from HL-60 cells bound to E-selectin, and tunicamycin treatment to abolish N-linked glycans from Bsg abrogated this binding. n-linked glycans 88-104 selectin E Homo sapiens 39-49 19443639-6 2009 Bsg isolated from HL-60 cells bound to E-selectin, and tunicamycin treatment to abolish N-linked glycans from Bsg abrogated this binding. n-linked glycans 88-104 basigin (Ok blood group) Homo sapiens 110-113 18778316-1 2009 Plant N-linked glycans differ substantially from their mammalian counterparts, mainly with respect to modifications of the core glycan, which typically contains a beta(1,2)-xylose and an alpha(1,3)-fucose. n-linked glycans 6-22 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 163-171 19303396-2 2009 We investigated whether NK group 2D (NKG2D) and CD94 can bind to sialylated N-linked glycans, using recombinant glutathione S-transferase-fused extracellular lectin-like domains of NKG2D (rNKG2Dlec) and CD94 (rCD94lec). n-linked glycans 76-92 killer cell lectin like receptor K1 Homo sapiens 24-35 19303396-2 2009 We investigated whether NK group 2D (NKG2D) and CD94 can bind to sialylated N-linked glycans, using recombinant glutathione S-transferase-fused extracellular lectin-like domains of NKG2D (rNKG2Dlec) and CD94 (rCD94lec). n-linked glycans 76-92 killer cell lectin like receptor K1 Homo sapiens 37-42 19303396-2 2009 We investigated whether NK group 2D (NKG2D) and CD94 can bind to sialylated N-linked glycans, using recombinant glutathione S-transferase-fused extracellular lectin-like domains of NKG2D (rNKG2Dlec) and CD94 (rCD94lec). n-linked glycans 76-92 killer cell lectin like receptor D1 Homo sapiens 48-52 19053835-3 2009 Applying a highly sensitive glycomics approach which included matrix-assisted laser-desorption ionization and electrospray ionization ion trap mass spectrometry, we have performed a detailed analysis of the N-linked glycans of CD24. n-linked glycans 207-223 CD24a antigen Mus musculus 227-231 18778316-1 2009 Plant N-linked glycans differ substantially from their mammalian counterparts, mainly with respect to modifications of the core glycan, which typically contains a beta(1,2)-xylose and an alpha(1,3)-fucose. n-linked glycans 6-22 adrenoceptor alpha 1D Homo sapiens 187-196 18922878-6 2008 Additionally, a panel of mutant viruses lacking either individual or multiple N-linked glycosylation sites was used to demonstrate that N-linked glycans were essential for high-level IFN-alpha/beta induction by the mammalian-cell-derived virus. n-linked glycans 136-152 interferon alpha 1 Homo sapiens 183-192 18632981-3 2008 To better understand the mechanisms regulating protein biogenesis in the mammalian ER, we determined the fate of five variants of soluble BACE with 4, 3, 2, 1, or 0 N-linked glycans. n-linked glycans 165-181 beta-secretase 1 Homo sapiens 138-142 18606998-4 2008 Klotho treatment increases cell-surface abundance of the renal epithelial Ca(2+) channel TRPV5 by modifying its N-linked glycans. n-linked glycans 112-128 klotho Homo sapiens 0-6 18606998-4 2008 Klotho treatment increases cell-surface abundance of the renal epithelial Ca(2+) channel TRPV5 by modifying its N-linked glycans. n-linked glycans 112-128 transient receptor potential cation channel subfamily V member 5 Homo sapiens 89-94 18426228-2 2008 The primary assay for characterization and lot release of N-linked glycans on glycoprotein products at Genentech, Inc., is a capillary electrophoresis (CE) based assay, wherein PNGase F-released, APTS-labeled glycans are separated by CE with laser induced fluorescence (LIF) detection. n-linked glycans 58-74 N-glycanase 1 Homo sapiens 177-183 18434410-5 2008 These yeast proteins, like HIV-1 gp120, contain a large number and high density of N-linked glycans, with glycosidase digestion abrogating 2G12 cross-reactivity. n-linked glycans 83-99 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 33-38 18381078-9 2008 Here, a fraction of ADAM10 from exosomes was found to contain more processed N-linked glycans than the cellular enzyme. n-linked glycans 77-93 ADAM metallopeptidase domain 10 Homo sapiens 20-26 18426978-5 2008 GT1 reglucosylated N-linked glycans in the slow-folding stem domain of HA once the nascent chain was released from the ribosome. n-linked glycans 19-35 beta-1,4-galactosyltransferase 1 Homo sapiens 0-3 18385798-5 2008 Cell surface beta1-6 branched N-oligosaccharides were measured by their specific binding to PHA-L followed by flow cytometry, and the fibronectin receptors bearing beta1-6 GlcNAc branched N-linked glycans were identified. n-linked glycans 188-204 fibronectin 1 Homo sapiens 134-145 17957771-0 2008 N-linked glycans of the human insulin receptor and their distribution over the crystal structure. n-linked glycans 0-16 insulin receptor Homo sapiens 30-46 17983356-7 2008 Endo H (endoglycosidase H) treatment and cell culture with alpha-glucosidase inhibitors demonstrated that N-linked glycans are of the complex mature type in the 170 kDa form and of the high-mannose type in the 130 kDa form. n-linked glycans 106-122 sucrase-isomaltase Homo sapiens 59-76 17983356-11 2008 Our findings show that N-linked glycans within Ig and/or FNIII domains regulate Ob-R function, but are not involved in essential interactions with the ligand. n-linked glycans 23-39 leptin receptor Homo sapiens 80-84 18854874-1 2008 alpha1,6-fucosyltransferase (FUT8) attaches fucose residues via an alpha1,6 linkage to the innermost N-acetylglucosamine residue of N-linked glycans. n-linked glycans 132-148 fucosyltransferase 8 Homo sapiens 0-27 17975018-10 2008 These data demonstrate that the N-linked glycans of VWF have a modulatory effect on the interaction with ADAMTS13. n-linked glycans 32-48 von Willebrand factor Homo sapiens 52-55 17975018-10 2008 These data demonstrate that the N-linked glycans of VWF have a modulatory effect on the interaction with ADAMTS13. n-linked glycans 32-48 ADAM metallopeptidase with thrombospondin type 1 motif 13 Homo sapiens 105-113 18322210-9 2008 Hence, N-linked glycans are critical determinants that can profoundly influence CD4 T cell recognition of HIV-1 gp120. n-linked glycans 7-23 CD4 molecule Homo sapiens 80-83 18322210-9 2008 Hence, N-linked glycans are critical determinants that can profoundly influence CD4 T cell recognition of HIV-1 gp120. n-linked glycans 7-23 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 112-117 18854874-1 2008 alpha1,6-fucosyltransferase (FUT8) attaches fucose residues via an alpha1,6 linkage to the innermost N-acetylglucosamine residue of N-linked glycans. n-linked glycans 132-148 fucosyltransferase 8 Homo sapiens 29-33 17634239-4 2007 Here we show that N-linked glycans in addition to the one at position 295 are important in the formation of the 2G12 epitope in subtype C gp120. n-linked glycans 18-34 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 138-143 17640971-1 2007 CD52 is composed of a 12 amino acid peptide with N-linked glycans bound to the single potential glycosylation site at position 3, and a glycosylphosphatidylinositol-anchor attached at the C-terminus. n-linked glycans 49-65 CD52 molecule Homo sapiens 0-4 17356011-8 2007 Studies with PNGase F and tunicamycin reveal the Slc37a2 protein is posttranslationally modified by addition of N-linked glycans. n-linked glycans 112-128 solute carrier family 37 (glycerol-3-phosphate transporter), member 2 Mus musculus 49-56 17545692-9 2007 These data show that individual N-linked glycans have unique and important effects on the phospholipase activity and substrate specificity of EL. n-linked glycans 32-48 lipase G, endothelial type Homo sapiens 142-144 18062249-12 2007 These results indicated that disruptions of MNN1 and OCH1 eliminated the hypermannosylation of the N-linked glycans, and glycoproteins were glycosylated with a single core type glycan, Man8 GlcNAc2, in the mnn1 och1 mutant. n-linked glycans 99-115 alpha-1,3-mannosyltransferase MNN1 Saccharomyces cerevisiae S288C 44-48 18062249-12 2007 These results indicated that disruptions of MNN1 and OCH1 eliminated the hypermannosylation of the N-linked glycans, and glycoproteins were glycosylated with a single core type glycan, Man8 GlcNAc2, in the mnn1 och1 mutant. n-linked glycans 99-115 initiation-specific alpha-1,6-mannosyltransferase Saccharomyces cerevisiae S288C 53-57 17678502-3 2007 A major concern is the presence of beta1,2-xylose and core alpha1,3-fucose residues on complex N-linked glycans, as these N-glycan epitopes are immunogenic in mammals. n-linked glycans 95-111 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 35-42 17678502-3 2007 A major concern is the presence of beta1,2-xylose and core alpha1,3-fucose residues on complex N-linked glycans, as these N-glycan epitopes are immunogenic in mammals. n-linked glycans 95-111 adrenoceptor alpha 1D Homo sapiens 59-67 17082223-0 2007 Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells. n-linked glycans 4-20 ATP binding cassette subfamily B member 11 Canis lupus familiaris 99-105 17481579-4 2007 N-linked glycans with the plant-specific sugars beta(1,2)-xylose and alpha(1,3)-fucose comprised 9.8%. n-linked glycans 0-16 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 48-56 17375095-0 2007 Rolling on N-linked glycans: a new way to present L-selectin binding sites. n-linked glycans 11-27 selectin L Homo sapiens 50-60 17384119-6 2007 This procedure was used to analyze N-linked glycans released from various mixtures of glycoproteins, such as alpha-1 acid glycoprotein, human transferrin, and bovine fetuin, using MS techniques that included matrix assisted laser desorption ionization-time of flight MS and electrospray ionization with ion cyclotron resonance-Fourier transformation MS. n-linked glycans 35-51 transferrin Homo sapiens 142-153 17493577-5 2007 Mass spectrometric analysis of cellular N-linked glycans revealed that depletion of VCP decreases the level of high-mannose glycoproteins, increases the levels of truncated low-mannose glycoproteins and induces changes in the abundance of complex glycans assembled in post-ER compartments. n-linked glycans 40-56 valosin containing protein Homo sapiens 84-87 17293352-6 2007 The N-linked glycans of recombinant human GAA (rhAGLU), isolated from the rabbit milk, were released by peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase F. The N-glycan pool was fractionated and purified into individual components by a combination of anion-exchange, normal-phase, and Sambucus nigra agglutinin-affinity chromatography. n-linked glycans 4-20 alpha glucosidase Homo sapiens 42-45 17264077-10 2007 Therefore, tollo/toll-8 signaling influences flux through several processing steps that affect the maturation of N-linked glycans. n-linked glycans 113-129 tollo Drosophila melanogaster 11-23 17082223-9 2007 In conclusion, at least two N-linked glycans are required for Bsep protein stability, intracellular trafficking, and function in the apical membrane. n-linked glycans 28-44 ATP binding cassette subfamily B member 11 Rattus norvegicus 62-66 17653303-4 2007 Our results show that N-linked glycans may play a role in proper azurocidin folding and subsequent secretion by insect cells. n-linked glycans 22-38 azurocidin 1 Homo sapiens 65-75 17212372-5 2007 Purified recombinant nephrin was subjected to peptide-N-glycosidase F (PNGase F) to enzymatically remove all the N-linked glycans. n-linked glycans 113-129 NPHS1 adhesion molecule, nephrin Homo sapiens 21-28 17152094-6 2007 On the other hand, in Trf, a glycoprotein with only two glycosylation sites, mainly biantennary complex-type-N-linked glycans are bound. n-linked glycans 109-125 transferrin Homo sapiens 22-25 17214553-2 2007 Within its cellular pathway, PrP(C) undergoes several posttranslational modifications, i.e., the attachment of two N-linked glycans and a glycosyl phosphatidyl inositol (GPI) anchor, by which it is linked to the plasma membrane on the exterior cell surface. n-linked glycans 115-131 major prion protein Cricetulus griseus 29-32 17244731-10 2007 These results indicate that N-linked glycans on ZP1 play an important role in triggering the AR in Japanese quail. n-linked glycans 28-44 zona pellucida sperm-binding protein 1 Coturnix japonica 48-51 16888005-0 2006 Activation of murine CD4+ and CD8+ T lymphocytes leads to dramatic remodeling of N-linked glycans. n-linked glycans 81-97 CD4 antigen Mus musculus 21-24 17071611-4 2006 There are four N-linked glycans on the CD1d heavy chain, and we mutated them individually to ascertain their importance for the assembly and function of CD1d-beta(2)m heterodimers. n-linked glycans 15-31 CD1d molecule Homo sapiens 39-43 17071611-4 2006 There are four N-linked glycans on the CD1d heavy chain, and we mutated them individually to ascertain their importance for the assembly and function of CD1d-beta(2)m heterodimers. n-linked glycans 15-31 CD1d molecule Homo sapiens 153-157 17071611-4 2006 There are four N-linked glycans on the CD1d heavy chain, and we mutated them individually to ascertain their importance for the assembly and function of CD1d-beta(2)m heterodimers. n-linked glycans 15-31 beta-2-microglobulin Homo sapiens 158-166 16919392-7 2006 We conclude that individual N-linked glycans are required for optimal transport of PLB1 to the cell surface and optimal secretion of both PLB1 and PLB1(GPI-). n-linked glycans 28-44 lysophospholipase Saccharomyces cerevisiae S288C 83-87 16919392-7 2006 We conclude that individual N-linked glycans are required for optimal transport of PLB1 to the cell surface and optimal secretion of both PLB1 and PLB1(GPI-). n-linked glycans 28-44 lysophospholipase Saccharomyces cerevisiae S288C 138-142 16919392-7 2006 We conclude that individual N-linked glycans are required for optimal transport of PLB1 to the cell surface and optimal secretion of both PLB1 and PLB1(GPI-). n-linked glycans 28-44 lysophospholipase Saccharomyces cerevisiae S288C 138-142 17165854-1 2006 N-Linked glycans derived from human and bovine alpha1-acid glycoprotein, as well as chicken egg white albumin, were analyzed by MALDI-TOF mass spectrometry using a novel MALDI matrix consisting of 2,5-dihydroxybenzoic acid (DHB) and aniline. n-linked glycans 0-16 alpha-1-acid glycoprotein Bos taurus 47-71 17067392-15 2006 The demonstration that N-linked glycans are essential for mediating mesothlein-MUC16 binding may lead to novel therapeutic targets to control the spread of ovarian carcinoma. n-linked glycans 23-39 mucin 16, cell surface associated Homo sapiens 79-84 16919392-2 2006 We demonstrated that removal of N-linked glycans from secreted cryptococcal PLB1 leads to loss of enzyme activity. n-linked glycans 32-48 lysophospholipase Saccharomyces cerevisiae S288C 76-80 16920935-2 2006 Its preferred ligand is the sequence Sia alpha2-6Gal that is abundantly expressed on N-linked glycans of B cell glycoproteins, and by binding to CD22 in cis causes CD22 to appear "masked" from binding to synthetic sialoside probes. n-linked glycans 85-101 CD22 molecule Homo sapiens 145-149 16920935-2 2006 Its preferred ligand is the sequence Sia alpha2-6Gal that is abundantly expressed on N-linked glycans of B cell glycoproteins, and by binding to CD22 in cis causes CD22 to appear "masked" from binding to synthetic sialoside probes. n-linked glycans 85-101 CD22 molecule Homo sapiens 164-168 16335978-2 2005 We have utilized micro-solution isoelectric focusing and affinity chromatography, prior to gel electrophoresis to enable site-specific structural determination of the N-linked glycans in apolipoprotein J with the use of FT-ICR MS. n-linked glycans 167-183 clusterin Homo sapiens 187-203 16819971-0 2006 Roles of N-linked glycans in the recognition of microbial lipopeptides and lipoproteins by TLR2. n-linked glycans 9-25 toll like receptor 2 Homo sapiens 91-95 16819971-8 2006 TLR2(N114A,N199A), TLR2(N114A,N414A) and, to a lesser extent, TLR2(N114A,N442A), in which two N-linked glycans are speculated to be exposed to the concave surface of TLR2 solenoid, not only induce NF-kappaB activation but also are associated with wild-type TLR2 and TLR6. n-linked glycans 94-110 toll like receptor 2 Homo sapiens 0-4 16819971-8 2006 TLR2(N114A,N199A), TLR2(N114A,N414A) and, to a lesser extent, TLR2(N114A,N442A), in which two N-linked glycans are speculated to be exposed to the concave surface of TLR2 solenoid, not only induce NF-kappaB activation but also are associated with wild-type TLR2 and TLR6. n-linked glycans 94-110 toll like receptor 2 Homo sapiens 19-23 16819971-8 2006 TLR2(N114A,N199A), TLR2(N114A,N414A) and, to a lesser extent, TLR2(N114A,N442A), in which two N-linked glycans are speculated to be exposed to the concave surface of TLR2 solenoid, not only induce NF-kappaB activation but also are associated with wild-type TLR2 and TLR6. n-linked glycans 94-110 toll like receptor 2 Homo sapiens 19-23 16819971-8 2006 TLR2(N114A,N199A), TLR2(N114A,N414A) and, to a lesser extent, TLR2(N114A,N442A), in which two N-linked glycans are speculated to be exposed to the concave surface of TLR2 solenoid, not only induce NF-kappaB activation but also are associated with wild-type TLR2 and TLR6. n-linked glycans 94-110 toll like receptor 2 Homo sapiens 19-23 16819971-8 2006 TLR2(N114A,N199A), TLR2(N114A,N414A) and, to a lesser extent, TLR2(N114A,N442A), in which two N-linked glycans are speculated to be exposed to the concave surface of TLR2 solenoid, not only induce NF-kappaB activation but also are associated with wild-type TLR2 and TLR6. n-linked glycans 94-110 toll like receptor 2 Homo sapiens 19-23 16819971-8 2006 TLR2(N114A,N199A), TLR2(N114A,N414A) and, to a lesser extent, TLR2(N114A,N442A), in which two N-linked glycans are speculated to be exposed to the concave surface of TLR2 solenoid, not only induce NF-kappaB activation but also are associated with wild-type TLR2 and TLR6. n-linked glycans 94-110 toll like receptor 6 Homo sapiens 266-270 16819971-9 2006 These results suggest that the glycan at Asn442 and at least two N-linked glycans speculated to be exposed to the concave surface of TLR2 solenoid are involved in the recognition of ligands by TLR2 and/or in formation or maturation of a functional TLR2 receptor complex. n-linked glycans 65-81 toll like receptor 2 Homo sapiens 133-137 16819971-9 2006 These results suggest that the glycan at Asn442 and at least two N-linked glycans speculated to be exposed to the concave surface of TLR2 solenoid are involved in the recognition of ligands by TLR2 and/or in formation or maturation of a functional TLR2 receptor complex. n-linked glycans 65-81 toll like receptor 2 Homo sapiens 193-197 16819971-9 2006 These results suggest that the glycan at Asn442 and at least two N-linked glycans speculated to be exposed to the concave surface of TLR2 solenoid are involved in the recognition of ligands by TLR2 and/or in formation or maturation of a functional TLR2 receptor complex. n-linked glycans 65-81 toll like receptor 2 Homo sapiens 193-197 16484342-5 2006 beta3Gal-T1, -T2, and -T5 could synthesize type 1 chains on N-linked glycans, but only beta3Gal-T5 worked on O-linked glycans. n-linked glycans 60-76 beta-1,3-galactosyltransferase 1 Homo sapiens 0-11 16291658-2 2006 We further define the nature of the epitope recognized by the 6C10 antibody to be a subset of Thy-1 bearing incompletely sialylated N-linked glycans, and furthermore, we demonstrate that tolerant CD4+ T cells have an increased degree of cell-surface sialylation. n-linked glycans 132-148 thymus cell antigen 1, theta Mus musculus 94-99 16414019-3 2006 While there is only little sequence homology to mammalian PrP, PrP-related fish proteins were predicted to be modified with N-linked glycans and a C-terminal glycosylphosphatidylinositol (GPI) anchor. n-linked glycans 124-140 prion protein Homo sapiens 63-66 16476981-2 2006 Loss of N-linked glycans and increased net charge of the third variable loop (V3) of the gp120 envelope glycoprotein have been observed to be important steps towards CXCR4 use. n-linked glycans 8-24 C-X-C motif chemokine receptor 4 Homo sapiens 166-171 16219759-1 2005 N-Linked glycans have been shown to have an important role in the cell biology of a variety of cell surface glycoproteins, including PrP protein. n-linked glycans 0-16 prion protein Mus musculus 133-136 16769084-1 2006 The Golgi-resident glycosyltransferase, UDP-N-acetyl-d-glucosamine:alpha-3-d-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I), initiates the conversion of high-mannose oligosaccharides to complex and hybrid structures in the biosynthesis of N-linked glycans. n-linked glycans 253-269 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Homo sapiens 40-129 16769084-1 2006 The Golgi-resident glycosyltransferase, UDP-N-acetyl-d-glucosamine:alpha-3-d-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I), initiates the conversion of high-mannose oligosaccharides to complex and hybrid structures in the biosynthesis of N-linked glycans. n-linked glycans 253-269 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Homo sapiens 131-136 16240719-7 2005 They were MNN9 which encodes protein involved in formation of outer chains of the N-linked glycans of secretory proteins and GWT1, encoding the protein of the endoplasmic reticulum involved in the glycosylphosphatidylinositol biosynthesis. n-linked glycans 82-98 mannosyltransferase complex subunit MNN9 Saccharomyces cerevisiae S288C 10-14 16014566-2 2005 In COS-7 cells transiently transfected with GPVI, deglycosylation with peptide-N-glycosidase F (PNGase F; specific for complex N-linked glycans) or tunicamycin decreases the molecular weight of GPVI and reduces transfected COS-7 cell binding to both CRP and CVX. n-linked glycans 127-143 glycoprotein VI platelet Homo sapiens 44-48 16014566-2 2005 In COS-7 cells transiently transfected with GPVI, deglycosylation with peptide-N-glycosidase F (PNGase F; specific for complex N-linked glycans) or tunicamycin decreases the molecular weight of GPVI and reduces transfected COS-7 cell binding to both CRP and CVX. n-linked glycans 127-143 glycoprotein VI platelet Homo sapiens 194-198 16091366-4 2005 Because the chaperone calnexin (CN) associates with N-linked glycans, we examined CN interactions with AChR subunits. n-linked glycans 52-68 calnexin Homo sapiens 22-30 16091366-4 2005 Because the chaperone calnexin (CN) associates with N-linked glycans, we examined CN interactions with AChR subunits. n-linked glycans 52-68 calnexin Homo sapiens 32-34 16091366-7 2005 Additionally, CN associations with subunits lacking N-linked glycans occurred without subunit aggregation or misfolding. n-linked glycans 52-68 calnexin Homo sapiens 14-16 15161941-7 2004 Based on these studies, we propose a model of tyrosinase degradation in which interactions between N-linked glycans and lectin chaperones help to minimize tyrosinase aggregation and also target non-native substrates for retro-translocation and subsequent degradation. n-linked glycans 99-115 tyrosinase Homo sapiens 46-56 16039588-1 2005 Nascent and newly synthesized glycoproteins enter the calnexin (Cnx)/calreticulin (Crt) cycle when two out of three glucoses in the core N-linked glycans have been trimmed sequentially by endoplasmic reticulum (ER) glucosidases I (GI) and II (GII). n-linked glycans 137-153 calnexin Homo sapiens 54-62 16039588-1 2005 Nascent and newly synthesized glycoproteins enter the calnexin (Cnx)/calreticulin (Crt) cycle when two out of three glucoses in the core N-linked glycans have been trimmed sequentially by endoplasmic reticulum (ER) glucosidases I (GI) and II (GII). n-linked glycans 137-153 calnexin Homo sapiens 64-67 16039588-1 2005 Nascent and newly synthesized glycoproteins enter the calnexin (Cnx)/calreticulin (Crt) cycle when two out of three glucoses in the core N-linked glycans have been trimmed sequentially by endoplasmic reticulum (ER) glucosidases I (GI) and II (GII). n-linked glycans 137-153 calreticulin Homo sapiens 69-81 15728736-7 2005 However, the transfection of GlcNAc6ST-1 resulted in significant sulfate incorporation into CD44 and generated the 6-sulfo LacNAc/Lewis x epitope on CD44, which was present largely on N-linked glycans. n-linked glycans 184-200 carbohydrate sulfotransferase 2 Homo sapiens 29-40 15728736-7 2005 However, the transfection of GlcNAc6ST-1 resulted in significant sulfate incorporation into CD44 and generated the 6-sulfo LacNAc/Lewis x epitope on CD44, which was present largely on N-linked glycans. n-linked glycans 184-200 CD44 molecule (Indian blood group) Homo sapiens 149-153 15919930-4 2005 Both resistant strains exhibited a variety of mutations eliminating N-linked glycans within gp120. n-linked glycans 68-84 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 92-97 15604092-0 2005 Analysis of N-linked glycans of porcine zona pellucida glycoprotein ZPA by MALDI-TOF MS: a contribution to understanding zona pellucida structure. n-linked glycans 12-28 zona pellucida glycoprotein 2 Homo sapiens 68-71 15824084-5 2005 PMN-derived CD44 binding activity is mediated by sialylated, alpha(1,3) fucosylated, N-linked glycans. n-linked glycans 85-101 CD44 molecule (Indian blood group) Homo sapiens 12-16 16201406-5 2005 Even though rhLF contains oligomannose- and hybrid-type N-linked glycans next to complex-type glycans, which are the only glycans found on natural hLF, the structures are identical within the experimental error (r.m.s. n-linked glycans 56-72 HLF transcription factor, PAR bZIP family member Homo sapiens 13-16 15751107-1 2005 N-Linked glycans from bovine ribonuclease B, chicken ovalbumin, bovine fetuin, porcine thyroglobulin and human alpha(1)-acid glycoprotein were derivatized with 2-aminobenzoic acid by reductive amination and their tandem mass spectra were recorded by negative ion electrospray ionization with a quadrupole time-of-flight mass spectrometer. n-linked glycans 0-16 ovalbumin (SERPINB14) Gallus gallus 53-62 15657052-7 2005 Both tissue-derived and recombinant testican-2 carried N-linked glycans. n-linked glycans 55-71 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 Mus musculus 36-46 11960993-10 2002 It has previously been proposed that labeling of the Drosophila neural system by anti-horseradish peroxidase antibodies is a result of the presence of difucosylated N-linked glycans. n-linked glycans 165-181 Peroxidase Drosophila melanogaster 98-108 14967486-9 2004 These experiments provide direct evidence that the presence of multiple N-linked glycans is required for the proper folding of the E2 protein in the ER and secretory pathway as well as for formation of its antigenic structure. n-linked glycans 72-88 ubiquitin conjugating enzyme E2 B Homo sapiens 131-141 12970565-4 2003 We document that alphaMbeta2 is a lectin that recognizes exposed beta-N-acetylglucosamine residues of N-linked glycans on GPIbalpha. n-linked glycans 102-118 glycoprotein Ib platelet subunit alpha Homo sapiens 122-131 12734200-6 2003 CA125 is also N-glycosylated, expressing primarily high mannose and complex bisecting type N-linked glycans. n-linked glycans 91-107 mucin 16, cell surface associated Homo sapiens 0-5 12489987-3 2002 Here we investigated the influence of the N-linked glycans g1 and g2 present on CXCR4 for HIV-1 infection. n-linked glycans 42-58 C-X-C motif chemokine receptor 4 Homo sapiens 80-85 12239218-6 2002 Here we show that CD1d associates in the ER with both calnexin and calreticulin and with the thiol oxidoreductase ERp57 in a manner dependent on glucose trimming of its N-linked glycans. n-linked glycans 169-185 CD1d molecule Homo sapiens 18-22 12239218-6 2002 Here we show that CD1d associates in the ER with both calnexin and calreticulin and with the thiol oxidoreductase ERp57 in a manner dependent on glucose trimming of its N-linked glycans. n-linked glycans 169-185 protein disulfide isomerase family A member 3 Homo sapiens 114-119 14707488-1 2002 The glycoprotein UDP-N-acetylglucosamine: beta-D-mannoside-1,4-N-acetylglucosaminyltransferase-III (GnT-III) catalyzes the addition of N-acetylglucosamine via a beta-1, 4-linkage to the beta-linked mannose of the trimannosyl core of N-linked glycans. n-linked glycans 233-249 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Homo sapiens 4-98 14707488-1 2002 The glycoprotein UDP-N-acetylglucosamine: beta-D-mannoside-1,4-N-acetylglucosaminyltransferase-III (GnT-III) catalyzes the addition of N-acetylglucosamine via a beta-1, 4-linkage to the beta-linked mannose of the trimannosyl core of N-linked glycans. n-linked glycans 233-249 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Homo sapiens 100-107 15056662-0 2004 Major histocompatibility complex class I molecules expressed with monoglucosylated N-linked glycans bind calreticulin independently of their assembly status. n-linked glycans 83-99 calreticulin Homo sapiens 105-117 15056662-4 2004 In vitro analysis of the assembly process has been limited by the specificity of calreticulin for monoglucosylated N-linked glycans, which are transient biosynthetic intermediates. n-linked glycans 115-131 calreticulin Homo sapiens 81-93 12952521-0 2003 Processing of N-linked glycans during endoplasmic-reticulum-associated degradation of a short-lived variant of ribophorin I. n-linked glycans 14-30 ribophorin I Homo sapiens 111-123 12904308-6 2003 However, the ZPA N-linked glycans were composed of acidic-complex and high-mannose oligosaccharides, ZPX had only high-mannose oligosaccharides, and ZPB lacked N-linked oligosaccharides. n-linked glycans 17-33 zzona pellucida glycoprotein 2 L homeolog Xenopus laevis 13-16 14623122-1 2003 UDP-N-acetylglucosamine:alpha(1,6)-D-mannoside beta(1,6)-N-acetylglucosaminyltransferase (GnT-V, Mgat5) functions in the biosynthesis of N-linked glycans and is transcriptionally upregulated by oncogene signaling. n-linked glycans 137-153 glucosaminyl (N-acetyl) transferase 1 Homo sapiens 47-88 14623122-1 2003 UDP-N-acetylglucosamine:alpha(1,6)-D-mannoside beta(1,6)-N-acetylglucosaminyltransferase (GnT-V, Mgat5) functions in the biosynthesis of N-linked glycans and is transcriptionally upregulated by oncogene signaling. n-linked glycans 137-153 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Homo sapiens 90-95 14623122-1 2003 UDP-N-acetylglucosamine:alpha(1,6)-D-mannoside beta(1,6)-N-acetylglucosaminyltransferase (GnT-V, Mgat5) functions in the biosynthesis of N-linked glycans and is transcriptionally upregulated by oncogene signaling. n-linked glycans 137-153 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Homo sapiens 97-102 12270713-2 2002 Similar to its membrane-bound homolog calnexin (CNX), it is a lectin that promotes the folding of proteins carrying N-linked glycans. n-linked glycans 116-132 calnexin Homo sapiens 48-51 12042249-2 2002 N-Linked glycans were released with peptide-N-glycosidase F (PNGase F) within gel from SDS-PAGE-isolated soluble and glycosylphosphatidylinositol (GPI)-anchored human CD59 expressed in CHO cells. n-linked glycans 0-16 CD59 molecule (CD59 blood group) Homo sapiens 167-171 11952786-6 2002 Trimming of the N-linked glycans gave rise to glycosylated Ac45-forms of approximately 61 and approximately 63 kDa that are cleaved to a C-terminal fragment of 42-44 kDa (the deglycosylated form is approximately 23 kDa), and a previously not detected approximately 22-kDa N-terminal cleavage fragment (the deglycosylated form is approximately 20 kDa). n-linked glycans 16-32 ATPase H+ transporting accessory protein 1 Homo sapiens 59-63 11590221-2 2001 We show that human macrophages synthesize PAF-AH as a premedial Golgi precursor containing high mannose N-linked glycans. n-linked glycans 104-120 phospholipase A2 group VII Homo sapiens 42-48 11901167-5 2002 The strongly reduced cellulose content of knf mutants indicates that N-linked glycans are required for cellulose biosynthesis. n-linked glycans 69-85 glucosidase 1 Arabidopsis thaliana 42-45 11834538-1 2002 To investigate whether the effect of ABO blood group on plasma von Willebrand factor (vWF) levels is mediated by the ABH antigenic determinants carried on N-linked glycans of vWF, we studied 158 group A and group O healthy volunteers. n-linked glycans 155-171 von Willebrand factor Homo sapiens 175-178 11754484-1 2002 The Saccharomyces cerevisiae OCH1 gene encodes an alpha-1,6-mannosyltransferase that initiates the polymannose outer chain elongation of N-linked glycans. n-linked glycans 137-153 initiation-specific alpha-1,6-mannosyltransferase Saccharomyces cerevisiae S288C 29-33 11754484-1 2002 The Saccharomyces cerevisiae OCH1 gene encodes an alpha-1,6-mannosyltransferase that initiates the polymannose outer chain elongation of N-linked glycans. n-linked glycans 137-153 alpha-1,6-mannosyltransferase Saccharomyces cerevisiae S288C 50-79 11583570-1 2001 The N-linked glycans on transferrin and alpha(1)-antitrypsin from patients with congenital disorders of glycosylation type I have increased fucosylation and branching relative to normal controls. n-linked glycans 4-20 transferrin Homo sapiens 24-35 11868814-7 2002 Removal of the N-linked glycans from PH-20 with N-glycosidase F shifted the molecular weight from 64 kd to approximately 54 kd, its deduced molecular weight based on sequence analysis, suggesting that most if not all, of the potential N-glycosylation sites are linked to oligosaccharides. n-linked glycans 15-31 sperm adhesion molecule 1 Homo sapiens 37-42 11672902-2 2001 DNA encoding HIV-1 env is a poorly efficient B-cell immunogen and one probable explanation is that the numerous gp120 N-linked glycans gp120 may interfere with B-cell epitope presentation. n-linked glycans 118-134 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 19-22 11672902-2 2001 DNA encoding HIV-1 env is a poorly efficient B-cell immunogen and one probable explanation is that the numerous gp120 N-linked glycans gp120 may interfere with B-cell epitope presentation. n-linked glycans 118-134 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 112-117 11672902-2 2001 DNA encoding HIV-1 env is a poorly efficient B-cell immunogen and one probable explanation is that the numerous gp120 N-linked glycans gp120 may interfere with B-cell epitope presentation. n-linked glycans 118-134 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 135-140 11676606-8 2001 Together, these results indicate that the presence of varied types of N-linked glycans on asparagine 240 of CD154 does not play a significant role in the CD40-CD154 interactions. n-linked glycans 70-86 CD40 ligand Homo sapiens 108-113 11590221-3 2001 Secreted PAF-AH possesses a molecular mass of approximately 55 kDa and contains mature N-linked glycans. n-linked glycans 87-103 phospholipase A2 group VII Homo sapiens 9-15 11467936-2 2001 A key enzyme in regulating the maturation of N-linked glycans is UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GlcNAc-TI, EC 2.4.1.101). n-linked glycans 45-61 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Oryctolagus cuniculus 65-151 11501752-12 2001 CONCLUSIONS: (1) The highest elevation of GnT-III and the close relationship between the WGA binding of BCa Fn with the pathological stage and grade of BCa indicate that the increase of bisecting GlcNAc in N-linked glycans contributes more to the malignant behavior of BCa than the increase of GnT-IV, GnT-V, and the antennary number. n-linked glycans 206-222 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Homo sapiens 42-49 11501752-12 2001 CONCLUSIONS: (1) The highest elevation of GnT-III and the close relationship between the WGA binding of BCa Fn with the pathological stage and grade of BCa indicate that the increase of bisecting GlcNAc in N-linked glycans contributes more to the malignant behavior of BCa than the increase of GnT-IV, GnT-V, and the antennary number. n-linked glycans 206-222 fibronectin 1 Homo sapiens 108-110 11467936-2 2001 A key enzyme in regulating the maturation of N-linked glycans is UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GlcNAc-TI, EC 2.4.1.101). n-linked glycans 45-61 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Oryctolagus cuniculus 153-162 11485624-2 2001 Here, we determined whether N-linked glycans of other gp120 domains were also involved in protection of V3 neutralization epitopes. n-linked glycans 28-44 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 54-59 11485624-4 2001 gp120 from both mutated viral clones had higher electrophoretic mobilities than gp120 from wild-type virus, confirming loss of N-linked glycans. n-linked glycans 127-143 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 0-5 11485624-9 2001 In conclusion, one or more N-linked glycans of gp120 V1 is engaged in protection of the V3 region from potential neutralizing antibodies, and this effect is dependent on the oligomeric organization of gp120/gp41. n-linked glycans 27-43 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 47-52 11485624-9 2001 In conclusion, one or more N-linked glycans of gp120 V1 is engaged in protection of the V3 region from potential neutralizing antibodies, and this effect is dependent on the oligomeric organization of gp120/gp41. n-linked glycans 27-43 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 201-206 11677785-7 2001 Profiles of the N-linked glycans of the individual isoforms of alpha 1-antitrypsin were obtained by MALDI-TOF. n-linked glycans 16-32 serpin family A member 1 Homo sapiens 63-82 11376005-7 2001 Mapping studies using CD2 point mutation, deletion, and chimeric molecules suggest that conformational change in the CD2 ectodomain participates in inducible raft association and excludes the membrane-proximal N-linked glycans, the transmembrane segment, and the CD2 cytoplasmic region (residues 8-117) as necessary for translocation. n-linked glycans 210-226 CD2 molecule Homo sapiens 117-120 11376005-7 2001 Mapping studies using CD2 point mutation, deletion, and chimeric molecules suggest that conformational change in the CD2 ectodomain participates in inducible raft association and excludes the membrane-proximal N-linked glycans, the transmembrane segment, and the CD2 cytoplasmic region (residues 8-117) as necessary for translocation. n-linked glycans 210-226 CD2 molecule Homo sapiens 117-120 11256998-4 2001 We demonstrate a major difference in the galactosylation of N-linked glycans isolated from neuronal (i.e. brain-derived) SIRP alpha as compared to myeloid (i.e. spleen-derived) SIRP alpha, with neuronal SIRP alpha almost completely lacking galactose. n-linked glycans 60-76 signal regulatory protein alpha Homo sapiens 121-131 11298743-4 2001 We first targeted a cluster of three N-linked glycans in the LHR (N295, N303, N317) in a region corresponding to the primary TSHR cleavage site, which has only one N-linked glycan. n-linked glycans 37-53 thyroid stimulating hormone receptor Homo sapiens 125-129 11287403-1 2001 The alpha1,6 fucosyltransferase (alpha1,6 FucT) catalyzes the transfer of a fucose from GDP-fucose to the innermost GlcNAc residue of N-linked glycans via an alpha1,6 linkage. n-linked glycans 134-150 fucosyltransferase 8 Mus musculus 4-31 11315257-8 2001 In contrast, GnT-V-AS/7721 cells showed reduction of both GnT-V activity and content of the beta 1,6 branch in N-linked glycans, elevation of cell attachment to Fn or Ln, and decline of cell migration and invasion through matrigel. n-linked glycans 111-127 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Homo sapiens 13-18 11315257-11 2001 The product of GnT-V, the beta 1,6 GlcNAc branch in N-linked glycans, is a structural factor of adhesion inhibition and invasion promotion. n-linked glycans 52-68 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Homo sapiens 15-20 11287403-1 2001 The alpha1,6 fucosyltransferase (alpha1,6 FucT) catalyzes the transfer of a fucose from GDP-fucose to the innermost GlcNAc residue of N-linked glycans via an alpha1,6 linkage. n-linked glycans 134-150 fucosyltransferase 8 Mus musculus 33-46 11181557-0 2001 Loss of N-linked glycans in the V3-loop region of gp120 is correlated to an enhanced infectivity of HIV-1. n-linked glycans 8-24 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 50-55 11161453-4 2001 Immunoblotting studies revealed that the PrP(C) glycoforms and the composition of the N-linked glycans on PrP(C) in human PBMC are different from those of the brain or the neuroblastoma cells. n-linked glycans 86-102 prion protein Homo sapiens 106-112 11159917-2 2000 The HSV-1 glycoprotein gC-1 is highly glycosylated and contains not only N-linked glycans but also a large number of O-linked glycans, some of which are clustered into two pronase-resistant arrays in the vicinity of the HSV-1 receptor-binding domain of gC-1. n-linked glycans 73-89 solute carrier family 25 member 22 Homo sapiens 23-27 11095749-3 2000 This L-selectin ligand activity of CD44 requires sialofucosylated N-linked glycans and is sulfation-independent. n-linked glycans 66-82 selectin L Homo sapiens 5-15 11095749-3 2000 This L-selectin ligand activity of CD44 requires sialofucosylated N-linked glycans and is sulfation-independent. n-linked glycans 66-82 CD44 molecule (Indian blood group) Homo sapiens 35-39 11030742-2 2000 To investigate the influence of both the two N-linked glycans, Asn181 and Asn197, and of the GPI anchor attached to Ser230, on the structural, dynamical and electrostatic behavior of PrP, we have undertaken molecular dynamics simulations on the C-terminal region of human prion protein HU:PrP(90-230), with and without the three glycans. n-linked glycans 45-61 prion protein Homo sapiens 183-186 10814701-1 2000 UDP-GlcNAc: Manalpha1-6Manbeta-R beta1-6 N-acetylglucosaminyltransferase V (EC 2.4.1.155, GlcNAc-TV) is a Golgi enzyme that substitutes the trimannosyl core in the biosynthetic pathway for complex-type N-linked glycans. n-linked glycans 202-218 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Homo sapiens 41-74 10908805-1 2000 The major cationic peanut (Arachis hypogaea) peroxidase, secreted into the extracellular space, is a glycoprotein with three N-linked glycans (polysaccharides) which are connected to the peptide backbone at Asn-60, Asn-144 and Asn-185. n-linked glycans 125-141 peroxidase N1-like Nicotiana tabacum 45-55 10913312-5 2000 Trapping of apo(a) N-linked glycans in their monoglucosylated form, by posttranslational inhibition of ER glucosidase activity with castanospermine (CST), enhanced apo(a)-CNX/CRT interaction and prevented both apo(a) secretion and ERAD. n-linked glycans 19-35 calnexin Homo sapiens 171-174 10913312-5 2000 Trapping of apo(a) N-linked glycans in their monoglucosylated form, by posttranslational inhibition of ER glucosidase activity with castanospermine (CST), enhanced apo(a)-CNX/CRT interaction and prevented both apo(a) secretion and ERAD. n-linked glycans 19-35 calreticulin Homo sapiens 175-178 10814701-1 2000 UDP-GlcNAc: Manalpha1-6Manbeta-R beta1-6 N-acetylglucosaminyltransferase V (EC 2.4.1.155, GlcNAc-TV) is a Golgi enzyme that substitutes the trimannosyl core in the biosynthetic pathway for complex-type N-linked glycans. n-linked glycans 202-218 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Homo sapiens 90-99 10782293-1 2000 Structures of the N-linked glycans released from porcine kidney diamine oxidase (DAO) were characterized utilizing various analytical techniques, including matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI/TOF-MS), high-performance capillary electrophoresis (HPCE), and high-pH anion-exchange chromatography with pulsed amperometric detection (HPAEC-PAD). n-linked glycans 18-34 amine oxidase copper containing 1 Homo sapiens 64-79 10700233-1 2000 Golgi beta1,6N-acetylglucosaminyltransferase V (MGAT5) is required in the biosynthesis of beta1,6GlcNAc-branched N-linked glycans attached to cell surface and secreted glycoproteins. n-linked glycans 113-129 mannoside acetylglucosaminyltransferase 5 Mus musculus 6-46 10700233-1 2000 Golgi beta1,6N-acetylglucosaminyltransferase V (MGAT5) is required in the biosynthesis of beta1,6GlcNAc-branched N-linked glycans attached to cell surface and secreted glycoproteins. n-linked glycans 113-129 mannoside acetylglucosaminyltransferase 5 Mus musculus 48-53 10782293-1 2000 Structures of the N-linked glycans released from porcine kidney diamine oxidase (DAO) were characterized utilizing various analytical techniques, including matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI/TOF-MS), high-performance capillary electrophoresis (HPCE), and high-pH anion-exchange chromatography with pulsed amperometric detection (HPAEC-PAD). n-linked glycans 18-34 amine oxidase copper containing 1 Homo sapiens 81-84 10518544-1 1999 One function of N-linked glycans is to assist in the folding of glycoproteins by mediating interactions of the lectin-like chaperone proteins calnexin and calreticulin with nascent glycoproteins. n-linked glycans 16-32 calnexin Homo sapiens 142-150 11114021-8 2000 The technique was applied to the structural determination of N-linked glycans from human secretory IgA and Apo-B 100 from human low-density lipoprotein. n-linked glycans 61-77 apolipoprotein B Homo sapiens 107-116 10529240-6 1999 More than 95% of the N-linked glycans attached to both gelatinase B and NGAL were partially sialylated, core-fucosylated biantennary structures with and without outer arm fucose. n-linked glycans 21-37 lipocalin 2 Homo sapiens 72-76 10514467-14 1999 These data confirm that male genital tract CD52 is distinct from the lymphocyte form by both N-linked glycans and COOH-terminal attached lipid anchor. n-linked glycans 93-109 CD52 molecule Homo sapiens 43-47 10617625-7 2000 Its N-linked glycans helped regulate the thermal stability of mMCP-7. n-linked glycans 4-20 tryptase alpha/beta 1 Mus musculus 62-68 10518544-1 1999 One function of N-linked glycans is to assist in the folding of glycoproteins by mediating interactions of the lectin-like chaperone proteins calnexin and calreticulin with nascent glycoproteins. n-linked glycans 16-32 calreticulin Homo sapiens 155-167 10486256-3 1999 Treatment of rats with this unphysiological precursor resulted in an incorporation of N-propanoylneuraminic acid into N-linked glycans of dipeptidyl peptidase IV. n-linked glycans 118-134 dipeptidylpeptidase 4 Rattus norvegicus 138-161 10548047-0 1999 Structure and function of the N-linked glycans of HBP/CAP37/azurocidin: crystal structure determination and biological characterization of nonglycosylated HBP. n-linked glycans 30-46 azurocidin 1 Homo sapiens 50-53 10548047-0 1999 Structure and function of the N-linked glycans of HBP/CAP37/azurocidin: crystal structure determination and biological characterization of nonglycosylated HBP. n-linked glycans 30-46 azurocidin 1 Homo sapiens 54-59 10548047-0 1999 Structure and function of the N-linked glycans of HBP/CAP37/azurocidin: crystal structure determination and biological characterization of nonglycosylated HBP. n-linked glycans 30-46 azurocidin 1 Homo sapiens 60-70 10548047-0 1999 Structure and function of the N-linked glycans of HBP/CAP37/azurocidin: crystal structure determination and biological characterization of nonglycosylated HBP. n-linked glycans 30-46 azurocidin 1 Homo sapiens 155-158 10484609-1 1999 The addition and endoplasmic reticulum (ER) glucosidase processing of N-linked glycans is essential for the secretion of rat hepatic lipase (HL). n-linked glycans 70-86 lipase C, hepatic type Rattus norvegicus 125-139 10484609-1 1999 The addition and endoplasmic reticulum (ER) glucosidase processing of N-linked glycans is essential for the secretion of rat hepatic lipase (HL). n-linked glycans 70-86 lipase C, hepatic type Rattus norvegicus 141-143 10484609-4 1999 Steady-state and pulse-chase labeling experiments established that human HL was synthesized as an ER-associated precursor containing high mannose N-linked glycans. n-linked glycans 146-162 lipase C, hepatic type Homo sapiens 73-75 10441510-1 1999 N-Acetylglucosaminyltransferase I (GlcNAcT-I, EC 2.4.1.101) is the enzyme which initiates the formation of complex N-linked glycans in eukaryotes by transforming GlcNAc to the oligo-mannosyl acceptor Man(5)GlcNAc(2)-Asn. n-linked glycans 115-131 alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase Arabidopsis thaliana 0-33 10441510-1 1999 N-Acetylglucosaminyltransferase I (GlcNAcT-I, EC 2.4.1.101) is the enzyme which initiates the formation of complex N-linked glycans in eukaryotes by transforming GlcNAc to the oligo-mannosyl acceptor Man(5)GlcNAc(2)-Asn. n-linked glycans 115-131 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Homo sapiens 35-44 10225975-8 1999 A novel glycoprotein ligand of 240 kDa carrying N-linked glycans was isolated from B-cell membranes by an E-selectin immunoadhesin. n-linked glycans 48-64 selectin E Homo sapiens 106-116 10350067-1 1999 In the present study we show that the H (0) blood group determinant Fuc alpha1-2Gal beta1-4GlcNAc beta1-R is present on N-linked glycans of soluble human L-selectin recombinantly expressed in baby hamster kidney (BHK) cells. n-linked glycans 120-136 selectin L Homo sapiens 154-164 10645146-2 1999 THP is heavily glycosylated by N-linked glycans, which are responsible for most of its properties. n-linked glycans 31-47 uromodulin Homo sapiens 0-3 9799111-11 1998 Carbohydrate analysis identified N-linked glycans on CD5 domains 1 and 2, and sialylated O-linked glycans on the linker peptide between domains 1 and 2. n-linked glycans 33-49 T-cell surface glycoprotein CD5 Cricetulus griseus 53-56 9820138-1 1998 The three flavivirus glycoproteins prM, E and NS1 are formed by post-translational cleavage and are glycosylated by the addition of N-linked glycans. n-linked glycans 132-148 influenza virus NS1A binding protein Homo sapiens 46-49 9859110-3 1998 Such tyrosine-based motifs have also been shown to act as basolateral targeting signals, whilst N-linked glycans (as occur on the extracytosolic domain of TGN38) can act as apical targeting signals. n-linked glycans 96-112 trans-golgi network protein 2 Homo sapiens 155-160 9637923-6 1998 Recently, the thiol oxidoreductase ERp57--also known as GRP58, ERp61, ER60, Q2, HIP-70, and CPT and first misidentified as phospholipase C-alpha--has been shown to bind in conjunction with calnexin or calreticulin to a number of newly synthesized ER glycoproteins when their N-linked glycans are trimmed by glucosidases I and II. n-linked glycans 275-291 protein disulfide isomerase family A member 3 Homo sapiens 35-40 9497314-3 1998 The type I membrane-protein calnexin and its soluble homologue calreticulin are constituents of this system that recognize monoglucosylated N-linked glycans that are present on unfolded glycoproteins. n-linked glycans 140-156 calnexin Homo sapiens 28-36 9555945-4 1998 The data from the combination of FAB spectrometry and linkage analysis show that the N-linked glycans present on recombinant LCAT (rLCAT) were composed primarily of triantennary and tetraantennary structures with and without core fucosylation. n-linked glycans 85-101 FA complementation group B Homo sapiens 33-36 9555945-4 1998 The data from the combination of FAB spectrometry and linkage analysis show that the N-linked glycans present on recombinant LCAT (rLCAT) were composed primarily of triantennary and tetraantennary structures with and without core fucosylation. n-linked glycans 85-101 lecithin-cholesterol acyltransferase Homo sapiens 125-129 9497314-3 1998 The type I membrane-protein calnexin and its soluble homologue calreticulin are constituents of this system that recognize monoglucosylated N-linked glycans that are present on unfolded glycoproteins. n-linked glycans 140-156 calreticulin Homo sapiens 63-75 9357103-1 1997 The N-linked glycans assembled in Pichia pastoris on the recombinant kringle 2 domain of human tissue-type plasminogen activator (r-[K2tPA]) are composed of approx. n-linked glycans 4-20 plasminogen activator, tissue type Homo sapiens 95-128 9442118-7 1998 Four distinct oligosaccharide structures were found to effect CD44-mediated HA binding: (a) the terminal alpha2,3-linked sialic acid on N-linked oligosaccharides inhibited binding; (b) the first N-linked N-acetylglucosamine residue enhanced binding; (c) O-linked glycans on N-deglycosylated CD44 enhanced binding; and (d) N-acetylgalactosamine incorporation into non-N-linked glycans augmented HA binding by cell surface CD44. n-linked glycans 367-383 CD44 antigen Cricetulus griseus 62-66 9299469-0 1997 NKR-P1A protein, an activating receptor of rat natural killer cells, binds to the chitobiose core of uncompletely glycosylated N-linked glycans, and to linear chitooligomers. n-linked glycans 127-143 killer cell lectin-like receptor subfamily B, member 1A Rattus norvegicus 0-7 9383252-7 1997 Its N-terminal and internal sequences, N-linked glycans, and enzymatic activity indicated that this allergen is a seed-specific peroxidase. n-linked glycans 39-55 peroxidase-like Triticum aestivum 128-138 9003768-4 1996 When expressed with two N-linked glycans in the presence of micromolar concentrations of deoxynojirimycin, this small soluble protein was found to bind firmly to both calnexin and calreticulin. n-linked glycans 24-40 calreticulin Bos taurus 180-192 9147064-1 1997 ST6Gal I (beta-galactoside alpha 2,6-sialyltransferase, SiaT-1, ST6N, EC 2.4.99.1) mediates the attachment of the alpha 2,6-sialyl linkage common on N-linked glycans. n-linked glycans 149-165 beta galactoside alpha 2,6 sialyltransferase 1 Mus musculus 0-8 9147064-1 1997 ST6Gal I (beta-galactoside alpha 2,6-sialyltransferase, SiaT-1, ST6N, EC 2.4.99.1) mediates the attachment of the alpha 2,6-sialyl linkage common on N-linked glycans. n-linked glycans 149-165 beta galactoside alpha 2,6 sialyltransferase 1 Mus musculus 56-62 9020131-0 1997 Reglucosylation of N-linked glycans is critical for calnexin assembly with T cell receptor (TCR) alpha proteins but not TCRbeta proteins. n-linked glycans 19-35 calnexin Homo sapiens 52-60 9672607-3 1997 In the present report we determined whether fucose units also were linked to the distal GlcNAc via alpha(1-3) or alpha(1-4) linkages in N-linked glycans of gp 120. n-linked glycans 136-152 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 156-162 9672607-4 1997 [3H]-fucose labelled gp 120 was subjected to endoglycosidase F digestion, releasing diantennary complex type N-linked glycans, but leaving the inner polypeptide-bound carbohydrates, GlcNAc and possibly associated fucose units, intact. n-linked glycans 109-125 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 21-27 9672607-7 1997 Altogether the results indicated presence of fucose units linked to peripheral GlcNAc of gp 120 N-linked glycans. n-linked glycans 96-112 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 89-95 9672607-8 1997 We have earlier shown that other peripheral carbohydrate determinants, i.e. beta(1-4)-galactose on N-linked glycans, maintain a correct antigenic conformation of gp 120. n-linked glycans 99-115 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 76-84 9672607-8 1997 We have earlier shown that other peripheral carbohydrate determinants, i.e. beta(1-4)-galactose on N-linked glycans, maintain a correct antigenic conformation of gp 120. n-linked glycans 99-115 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 162-168 9672607-9 1997 Using a coupled ELISA system, where changes in antigenic behaviour of a viral glycoprotein were correlated to stepwise elimination of peripheral monosaccharides from N-linked glycans, we found that treatment of gp 120 with a pan-specific alpha-fucosidase as well as an enzyme specific for alpha(1-3)- or alpha(1-4)-linked fucose disclosed a hidden linear epitope situated in the gp 120 C2 region. n-linked glycans 166-182 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 211-217 9003768-4 1996 When expressed with two N-linked glycans in the presence of micromolar concentrations of deoxynojirimycin, this small soluble protein was found to bind firmly to both calnexin and calreticulin. n-linked glycans 24-40 calnexin Bos taurus 167-175 9228058-2 1997 When human soluble FasL (sFasL, containing the extracellular portion) was expressed in human embryo kidney 293 cells, the three N-linked glycans of each FasL monomer were found to be essential for efficient secretion. n-linked glycans 128-144 Fas ligand Homo sapiens 19-23 9228058-2 1997 When human soluble FasL (sFasL, containing the extracellular portion) was expressed in human embryo kidney 293 cells, the three N-linked glycans of each FasL monomer were found to be essential for efficient secretion. n-linked glycans 128-144 Fas ligand Homo sapiens 26-30 9153399-8 1997 A bend between domains 1 and 2 of ICAM-2 and a tripod-like arrangement of N-linked glycans in the membrane-proximal region of domain 2 may be important for presenting the recognition surface to LFA-1. n-linked glycans 74-90 integrin subunit alpha L Homo sapiens 194-199 9013598-3 1997 The mass spectra of the glycopeptides exhibit characteristic clusters of peaks which indicate the N-linked glycans in tACE to be mostly of the biantennary, fucosylated complex type. n-linked glycans 98-114 ADAM metallopeptidase domain 17 Homo sapiens 118-122 9672607-0 1997 Demonstration of peripheral fucose units in N-linked glycans of human immunodeficiency virus type 1 gp 120: effects on glycoprotein conformation. n-linked glycans 44-60 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 100-106 8955372-0 1996 Calnexin can interact with N-linked glycans located close to the endoplasmic reticulum membrane. n-linked glycans 27-43 calnexin Homo sapiens 0-8 8943049-0 1996 Deglucosylation of N-linked glycans is an important step in the dissociation of calreticulin-class I-TAP complexes. n-linked glycans 19-35 calreticulin Mus musculus 80-92 8943049-4 1996 Finally, these studies show that deglucosylation of N-linked glycans is important for dissociation of class I proteins from both calreticulin and TAP and that the vast majority of newly synthesized class I proteins associated with calreticulin are simultaneously assembled with TAP. n-linked glycans 52-68 calreticulin Mus musculus 129-141 8910328-1 1996 The Lec4A and Lec4 Chinese hamster ovary glycosylation mutants lack N-linked glycans with GlcNAcbeta(1,6)Manalpha(1,6) branches that are initiated by the transferase termed GlcNAc-TV. n-linked glycans 68-84 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A Cricetulus griseus 173-182 8687384-4 1996 Further we show that Bowes t-PA expresses glucuronic acid/sulphate containing N-linked glycans and is recognized by anti-carbohydrate L2/HNK-1 monoclonal antibodies. n-linked glycans 78-94 chromosome 20 open reading frame 181 Homo sapiens 27-31 8673525-2 1996 The aim of the present study was to explore the possibility to obtain a more broadly neutralizing immune response by immunizing guinea pigs with gp160 depleted of three N-linked glycans in the CD4-binding domain by site-directed mutagenesis. n-linked glycans 169-185 glutamyl aminopeptidase Homo sapiens 145-150 8673525-8 1996 These data indicated that elimination of the three N-linked glycans from gp160 resulted in an altered local antigenic conformation but did not uncover hidden neutralization epitopes, broadening the immune response. n-linked glycans 51-67 glutamyl aminopeptidase Homo sapiens 73-78 8888624-2 1996 In Arabidopsis seedlings, accumulation of transcripts for BiP was induced not only by inhibition of the N-glycosylation of proteins by tunicamycin but also by inhibition of the processing of N-linked glycans by castanospermine. n-linked glycans 191-207 Heat shock protein 70 (Hsp 70) family protein Arabidopsis thaliana 58-61 8673525-0 1996 Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response. n-linked glycans 13-29 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 98-103 8687384-2 1996 This study clarified an earlier discrepancy in the literature and confirmed that the major complex N-linked glycans on Bowes t-PA that carry sialic acid as their sole charged group are bi-antennary, core fucosylated, with terminal N-acetylgalactosamine residues. n-linked glycans 99-115 chromosome 20 open reading frame 181 Homo sapiens 125-129 8560759-0 1996 N-linked glycans in the CD4-binding domain of human immunodeficiency virus type 1 envelope glycoprotein gp160 are essential for the in vivo priming of T cells recognizing an epitope located in their vicinity. n-linked glycans 0-16 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 104-109 8973529-1 1996 We have constructed a mutated infectious HIV variant lacking the signals for addition of three N-linked glycans situated in the V4, C4 and V5 regions of HIV gp120. n-linked glycans 95-111 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 157-162 8950359-8 1996 In contrast, only high mannose-type N-linked glycans are present on the PSMA from LNCaP cells. n-linked glycans 36-52 folate hydrolase 1 Homo sapiens 72-76 8950359-10 1996 N-linked glycans of PSMA derived from in vivo sources were found to be complex type, lacking polylactosamine structures. n-linked glycans 0-16 folate hydrolase 1 Homo sapiens 20-24 7538125-4 1995 The inefficient folding of hCG-beta lacking both N-linked glycans correlated with the slow formation of the last three disulfide bonds (i.e. disulfides 23-72, 93-100, and 26-110) to form in the hCG-beta-folding pathway. n-linked glycans 49-65 chorionic gonadotropin subunit beta 3 Homo sapiens 27-35 8524845-1 1995 Golgi alpha-mannosidase II (alpha-MII) is an enzyme involved in the processing of N-linked glycans. n-linked glycans 82-98 mannosidase alpha class 2A member 1 Homo sapiens 0-26 7500048-3 1995 Although calnexin association with several membrane glycoproteins depends on interactions involving N-linked glycans, we previously reported that a truncation mutant of mouse Ii (mIi1-107) lacking both N-glycosylation sites was highly effective in associating with MHC class II heterodimers and escorting these dimers through the secretory pathway. n-linked glycans 100-116 calnexin Mus musculus 9-17 7538125-6 1995 However, coexpression of the hCG-alpha gene enhanced folding and formation of disulfide bonds 23-72, 93-100, and 26-110 of hCG-beta lacking N-linked glycans. n-linked glycans 140-156 chromogranin A Homo sapiens 29-38 7795417-4 1995 The bulk of the N-linked glycans of hyaluronidase consisted of small oligosaccharides (Man1-3GlcNAc2), most of which were either alpha 1,3-monofucosylated or alpha 1,3-(alpha 1,6-)difucosylated at the innermost GlcNAc residue. n-linked glycans 16-32 hyaluronidase Apis mellifera 36-49 7867650-6 1995 The decrease in bioactivity caused by desialylation of hCG was only restored upon alpha 6-sialylation of the Gal beta 1-->4GlcNAc beta 1-->-2Man alpha 1-->3Man branch of the N-linked glycans. n-linked glycans 183-199 chorionic gonadotropin subunit beta 5 Homo sapiens 55-58 7929059-10 1994 In addition to the O-linked glycans, both components in the sAP complex contained N-linked glycans. n-linked glycans 82-98 SH2 domain containing 1A Homo sapiens 60-63 7523139-0 1994 Induction of HIV-1 envelope (gp120)-specific cytotoxic T lymphocyte responses in mice by recombinant CHO cell-derived gp120 is enhanced by enzymatic removal of N-linked glycans. n-linked glycans 160-176 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 29-34 7523139-0 1994 Induction of HIV-1 envelope (gp120)-specific cytotoxic T lymphocyte responses in mice by recombinant CHO cell-derived gp120 is enhanced by enzymatic removal of N-linked glycans. n-linked glycans 160-176 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 118-123 7523139-9 1994 However, envelope-specific CD8+ CTL activity was elicited when N-linked glycans were removed by treatment with an endoglycosidase. n-linked glycans 63-79 CD8a molecule Homo sapiens 27-30 7530195-8 1995 These data thus show that N-linked glycans play their most important role in the folding component of the folding and assembly pathway for hCG-beta. n-linked glycans 26-42 chorionic gonadotropin subunit beta 3 Homo sapiens 139-147 7927504-5 1994 Myeloma IgA1 and IgA2 proteins and secretory IgA had higher C3b-binding activity than normal serum IgA, and this was further increased by removal of sialic acid and N-linked glycans. n-linked glycans 165-181 immunoglobulin heavy constant alpha 1 Homo sapiens 8-12 7927504-5 1994 Myeloma IgA1 and IgA2 proteins and secretory IgA had higher C3b-binding activity than normal serum IgA, and this was further increased by removal of sialic acid and N-linked glycans. n-linked glycans 165-181 complement C3 Homo sapiens 60-63 1385399-3 1992 We have defined an important role for the N-linked glycans attached to Asn65 of this domain in mediating CD2-CD58 interactions and also characterize its N-glycotype structure. n-linked glycans 42-58 CD2 molecule Homo sapiens 105-108 8129620-0 1994 Identification of three N-linked glycans in the V4-V5 region of HIV-1 gp 120, dispensable for CD4-binding and fusion activity of gp 120. n-linked glycans 24-40 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 70-76 8129620-0 1994 Identification of three N-linked glycans in the V4-V5 region of HIV-1 gp 120, dispensable for CD4-binding and fusion activity of gp 120. n-linked glycans 24-40 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 129-135 8129620-1 1994 Site-directed mutagenesis was used to study the biological significance of three N-linked glycans (linked to Asn406, Asn448, and Asn463), situated in the CD4-binding region of gp120. n-linked glycans 81-97 CD4 molecule Homo sapiens 154-157 8129620-1 1994 Site-directed mutagenesis was used to study the biological significance of three N-linked glycans (linked to Asn406, Asn448, and Asn463), situated in the CD4-binding region of gp120. n-linked glycans 81-97 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 176-181 8129620-6 1994 All mutated gp120 species had the expected electrophoretical mobility as anticipated from elimination of one, two, and three N-linked glycans, respectively. n-linked glycans 125-141 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 12-17 8382038-3 1993 The PdU-induced changes in N-linked glycans, released by pronase digestion of the HSV-specified glycoprotein gC-1, were investigated by using lectin affinity chromatography and Bio-Gel P6 gel filtration of glycans, radiolabelled with [3H]galactose or [3H]glucosamine. n-linked glycans 27-43 guanylate cyclase 2e Mus musculus 109-113 7832633-1 1994 Glycosylation is necessary for HIV-1 gp120 to attain a functional conformation, and individual N-linked glycans of gp120 are important, but not essential, for replication of HIV-1 in cell culture. n-linked glycans 95-111 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 115-120 7937345-2 1994 Treatment of the receptor with glycopeptidase F generated a protein with a M(r) of 51,000, indicating that the GLP-1 receptor contains N-linked glycans. n-linked glycans 135-151 glucagon-like peptide 1 receptor Rattus norvegicus 111-125 8497042-1 1993 The role of three N-linked glycans which are conserved among various hemagglutinin (HA) subtypes of influenza A viruses was investigated by eliminating the conserved glycosylation (cg) sites at asparagine residues 12 (cg1), 28 (cg2), and 478 (cg3) by site-directed mutagenesis. n-linked glycans 18-34 transmembrane protein 245 Homo sapiens 228-231 1281869-0 1992 Carbohydrate determinant NeuAc-Gal beta (1-4) of N-linked glycans modulates the antigenic activity of human immunodeficiency virus type 1 glycoprotein gp120. n-linked glycans 49-65 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 151-156 1281869-1 1992 In the present study we investigated to what extent the peripheral carbohydrate structure of N-linked glycans influences the antigenic properties of human immunodeficiency virus type 1 glycoprotein 120 (gp120). n-linked glycans 93-109 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 203-208 1429599-4 1992 Analysis on IEF was combined with a neuraminidase protection assay, in which sialic acid modification of the N-linked glycans present on Tfr and Class I molecules is used as a reporter group for cell surface expression. n-linked glycans 109-125 transferrin receptor Homo sapiens 137-140 1385399-3 1992 We have defined an important role for the N-linked glycans attached to Asn65 of this domain in mediating CD2-CD58 interactions and also characterize its N-glycotype structure. n-linked glycans 42-58 CD58 molecule Homo sapiens 109-113 1721027-6 1991 Complex-type N-linked glycans are not required for ELAM-1 mediated adhesion, and therefore the ligand for ELAM-1 is most likely a glycolipid, or a glycoprotein carrying O-linked oligosaccharides. n-linked glycans 13-29 selectin E Homo sapiens 106-112 1396689-4 1992 Porcine thyroglobulin was shown to carry the mannose 6-phosphate-(Man6P)-recognition marker on its N-linked glycans. n-linked glycans 99-115 thyroglobulin Homo sapiens 8-21 1627608-5 1992 The results showed that N-linked glycans on placental syncytiotrophoblast and cytotrophoblast, kidney and platelet MCP are similar in binding to concanavalin A and Lens culinaris lectins, but are not bound by leucophytohemagglutinin. n-linked glycans 24-40 CD46 molecule Homo sapiens 115-118 1371154-0 1992 Detection of multisulphated N-linked glycans in the L2/HNK-1 carbohydrate epitope expressing neural adhesion molecule P0. n-linked glycans 28-44 beta-1,3-glucuronyltransferase 1 Homo sapiens 55-60 1744125-3 1991 Purified betaglycan has properties similar to betaglycan affinity-labeled in intact cells: it binds TGF-beta 1 and TGF-beta 2 with KD approximately 0.2 nM, contains heparan sulfate and chondroitin sulfate glycosaminoglycan (GAG) chains and N-linked glycans attached to a 110-kDa core protein, and can spontaneously associate with phosphatidylcholine liposomes. n-linked glycans 240-256 transforming growth factor beta receptor 3 Rattus norvegicus 9-19 1710649-11 1991 Two recombinant NS1 forms were detected in insect cells: a major one with an apparent Mr of 48K and a minor one of 47K in which N-linked glycans were probably processed to a trimannosyl core without further elongation. n-linked glycans 128-144 influenza virus NS1A binding protein Homo sapiens 16-19 1895386-6 1991 The gs3- mutation affected a second posttranslational modification of unknown type, which was manifested as production of gp70 that remained smaller than wild-type gp70 after removal of all N-linked glycans by peptide N-glycosidase F. The gs4- mutation decreased processing of gPr80 to gPr90, completely inhibited proteolytic processing of gPr90 to gp70 and Pr15(E), and prevented incorporation of envelope products into virus particles. n-linked glycans 190-206 DnaJ heat shock protein family (Hsp40) member C21 Homo sapiens 4-7 1895386-6 1991 The gs3- mutation affected a second posttranslational modification of unknown type, which was manifested as production of gp70 that remained smaller than wild-type gp70 after removal of all N-linked glycans by peptide N-glycosidase F. The gs4- mutation decreased processing of gPr80 to gPr90, completely inhibited proteolytic processing of gPr90 to gp70 and Pr15(E), and prevented incorporation of envelope products into virus particles. n-linked glycans 190-206 embigin Homo sapiens 122-126 2335819-1 1990 We have shown that enzymatic removal of N-linked glycans from human immunodeficiency virus type 1 (HIV-1) recombinant envelope glycoproteins gp160 and gp120 produced in BHK-21 cells did not significantly reduce their ability to bind to CD4, the cellular receptor for the virus. n-linked glycans 40-56 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 141-146 2335819-1 1990 We have shown that enzymatic removal of N-linked glycans from human immunodeficiency virus type 1 (HIV-1) recombinant envelope glycoproteins gp160 and gp120 produced in BHK-21 cells did not significantly reduce their ability to bind to CD4, the cellular receptor for the virus. n-linked glycans 40-56 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 151-156 2335819-1 1990 We have shown that enzymatic removal of N-linked glycans from human immunodeficiency virus type 1 (HIV-1) recombinant envelope glycoproteins gp160 and gp120 produced in BHK-21 cells did not significantly reduce their ability to bind to CD4, the cellular receptor for the virus. n-linked glycans 40-56 T-cell surface glycoprotein CD4 Mesocricetus auratus 236-239 34806177-2 2022 N-acetylglucosaminyltransferase V (GnT-V) is the Golgi enzyme, and it has been reported that the beta1,6GlcNAc-branched N-linked glycans are associated with various cell behaviors. n-linked glycans 120-136 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Homo sapiens 0-33 34860526-6 2022 A formalin-fixed paraffin-embedded human prostate tissue was analyzed in negative ionization mode after tissue washing, antigen retrieval, and pneumatic application of PNGase F for enzymatic digestion of N-linked glycans. n-linked glycans 204-220 N-glycanase 1 Homo sapiens 168-174 34863021-0 2022 Removal of single-site N-linked glycans on factor VIII alters binding of domain-specific monoclonal antibodies. n-linked glycans 23-39 coagulation factor VIII Mus musculus 43-54 34863021-10 2022 CONCLUSIONS: Modifications of FVIII N-linked glycans reduced FVIII endocytosis by BMDCs and binding of domain-specific FVIII MAbs, but did not alter de novo antibody production in hemophilia A mice suggesting that N-glycans do not significantly contribute to inhibitor formation. n-linked glycans 36-52 coagulation factor VIII Mus musculus 61-66 34863021-10 2022 CONCLUSIONS: Modifications of FVIII N-linked glycans reduced FVIII endocytosis by BMDCs and binding of domain-specific FVIII MAbs, but did not alter de novo antibody production in hemophilia A mice suggesting that N-glycans do not significantly contribute to inhibitor formation. n-linked glycans 36-52 coagulation factor VIII Mus musculus 119-124 34806177-2 2022 N-acetylglucosaminyltransferase V (GnT-V) is the Golgi enzyme, and it has been reported that the beta1,6GlcNAc-branched N-linked glycans are associated with various cell behaviors. n-linked glycans 120-136 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Homo sapiens 35-40 34995415-1 2022 The pan-caspase inhibitor Z-VAD-fmk acts as an inhibitor of peptide:N-glycanase (NGLY1); an endoglycosidase which cleaves N-linked glycans from glycoproteins exported from the endoplasmic reticulum (ER) during ER-associated degradation (ERAD). n-linked glycans 122-138 N-glycanase 1 Homo sapiens 81-86 34494876-3 2021 Previous work has demonstrated the presence of N-linked glycans in ACE2. n-linked glycans 47-63 angiotensin converting enzyme 2 Homo sapiens 67-71 34213308-2 2021 The abundance of N-linked glycans across the SARS-CoV-2 spike protein is a potential source of heterogeneity among the many different vaccine candidates under investigation. n-linked glycans 17-33 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 56-61 35470665-1 2022 Dense glycosylation and the trimeric conformation of the human immunodeficiency virus-1 (HIV-1) envelope protein limit the accessibility of some cellular glycan processing enzymes and end up with high-mannose-type N-linked glycans on the envelope spike, among which the Man5GlcNAc2 structure occupies a certain proportion. n-linked glycans 214-230 endogenous retrovirus group K member 6, envelope Homo sapiens 96-112 35188715-2 2022 A remarkable feature of ACPA-IgG is the abundant expression of N-linked glycans in the variable domain. n-linked glycans 63-79 proteinase 3 Homo sapiens 24-28 35467485-1 2022 Dolichyl-phosphate N-acetylglucosaminephosphotransferase (dpagt1) inhibition is reported to kill tumor cells whose growth progression requires increased branching of N-linked glycans. n-linked glycans 166-182 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 Homo sapiens 58-64 35311117-5 2022 Mechanistically, we showed that STT3A transferred N-linked glycans to PD-L1, and TGF-beta1 could positively regulate STT3A expression through activating c-Jun to bind to STT3A promoter. n-linked glycans 50-66 STT3 oligosaccharyltransferase complex catalytic subunit A Homo sapiens 32-37 35311117-5 2022 Mechanistically, we showed that STT3A transferred N-linked glycans to PD-L1, and TGF-beta1 could positively regulate STT3A expression through activating c-Jun to bind to STT3A promoter. n-linked glycans 50-66 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 153-158 35509261-2 2022 A single alpha-(1,6)-fucosyltransferase (FUT8) is responsible for catalyzing the addition of an alpha-1,6-linked fucose residue to the first GlcNAc residue of the N-linked glycans. n-linked glycans 163-179 alpha-(1,6)-fucosyltransferase Cricetulus griseus 9-39 35509261-2 2022 A single alpha-(1,6)-fucosyltransferase (FUT8) is responsible for catalyzing the addition of an alpha-1,6-linked fucose residue to the first GlcNAc residue of the N-linked glycans. n-linked glycans 163-179 alpha-(1,6)-fucosyltransferase Cricetulus griseus 41-45 35406718-1 2022 N-Glycanase 1 (NGLY1) is a cytosolic enzyme involved in removing N-linked glycans of misfolded N-glycoproteins and is considered to be a component of endoplasmic reticulum-associated degradation (ERAD). n-linked glycans 65-81 N-glycanase 1 Homo sapiens 0-13 35406718-1 2022 N-Glycanase 1 (NGLY1) is a cytosolic enzyme involved in removing N-linked glycans of misfolded N-glycoproteins and is considered to be a component of endoplasmic reticulum-associated degradation (ERAD). n-linked glycans 65-81 N-glycanase 1 Homo sapiens 15-20 35178035-4 2021 We show that YadA from Y. enterocolitica serotype O:9 does not interact with the vitronectin protein itself but exclusively with its N-linked glycans. n-linked glycans 133-149 Adhesin Yersinia enterocolitica 13-17