PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17506820-7	2007	These data reveal CEACAM3 as a specific innate immune receptor that mediates the opsonin-independent clearance of CEACAM-binding bacteria via Syk, a molecular trigger for functional immunoreceptor responses of both the adaptive (TCR, BCR, FcR) and innate (Dectin-1, CEACAM3) immune systems.	ceacam	18-24	spleen associated tyrosine kinase	Homo sapiens	142-145
22469950-5	2012	Compared to different well-studied phagocytic receptors, such as Fcgamma receptors and Dectin-1, CEACAM3 appears as an example of a hemITAM-containing innate immune receptor, which promotes rapid internalization and intracellular destruction of a diverse group of CEACAM-binding bacteria.	ceacam	97-103	C-type lectin domain containing 7A	Homo sapiens	87-95
22768164-3	2012	Uptake of Neisseria gonorrhoeae, a gram-negative human pathogen, via CEACAMs found on epithelial cells, such as CEACAM1, CEA or CEACAM6, differs mechanistically from phagocytosis mediated by CEACAM3, a CEACAM family member expressed selectively by human granulocytes.	ceacam	69-75	CEA cell adhesion molecule 1	Homo sapiens	112-119
22768164-3	2012	Uptake of Neisseria gonorrhoeae, a gram-negative human pathogen, via CEACAMs found on epithelial cells, such as CEACAM1, CEA or CEACAM6, differs mechanistically from phagocytosis mediated by CEACAM3, a CEACAM family member expressed selectively by human granulocytes.	ceacam	69-75	CEA cell adhesion molecule 3	Homo sapiens	191-198
20737948-1	2010	OBJECTIVE: To examine the expression of CEACAM-land CXCL-14 in the different stages of infantile hemangioma and to explore the role of CEACAM-1 and CXCL-14 in the occurrence and development of infantile hemangioma.	ceacam	40-46	C-X-C motif chemokine ligand 14	Homo sapiens	52-59
18606569-2	2008	In contrast to other members of the CEACAM family, CEACAM3 does not support cell-cell adhesion, but rather mediates the opsonin-independent recognition and elimination of a restricted set of human-specific Gram-negative bacterial pathogens including Neisseria gonorrhoeae, Haemophilus influenzae, and Moraxella catarrhalis.	ceacam	36-42	CEA cell adhesion molecule 3	Homo sapiens	51-58
18278069-6	2008	Moreover, we provide evidence that the naturally occurring CEACAM family member CEA is an inducer of CEACAM1-mediated apoptosis in HT29 colon cancer cells, an effect that depends on the abundance of CEACAM1 on the cell surface.	ceacam	59-65	CEA cell adhesion molecule 1	Homo sapiens	101-108
18278069-6	2008	Moreover, we provide evidence that the naturally occurring CEACAM family member CEA is an inducer of CEACAM1-mediated apoptosis in HT29 colon cancer cells, an effect that depends on the abundance of CEACAM1 on the cell surface.	ceacam	59-65	CEA cell adhesion molecule 1	Homo sapiens	199-206
17506820-7	2007	These data reveal CEACAM3 as a specific innate immune receptor that mediates the opsonin-independent clearance of CEACAM-binding bacteria via Syk, a molecular trigger for functional immunoreceptor responses of both the adaptive (TCR, BCR, FcR) and innate (Dectin-1, CEACAM3) immune systems.	ceacam	18-24	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	229-232
17506820-7	2007	These data reveal CEACAM3 as a specific innate immune receptor that mediates the opsonin-independent clearance of CEACAM-binding bacteria via Syk, a molecular trigger for functional immunoreceptor responses of both the adaptive (TCR, BCR, FcR) and innate (Dectin-1, CEACAM3) immune systems.	ceacam	18-24	C-type lectin domain containing 7A	Homo sapiens	256-264
17506820-7	2007	These data reveal CEACAM3 as a specific innate immune receptor that mediates the opsonin-independent clearance of CEACAM-binding bacteria via Syk, a molecular trigger for functional immunoreceptor responses of both the adaptive (TCR, BCR, FcR) and innate (Dectin-1, CEACAM3) immune systems.	ceacam	18-24	CEA cell adhesion molecule 3	Homo sapiens	266-273
17339478-8	2007	These data support the view that, different from canonical ITAM signaling, the CEACAM3 ITAM-like sequence short-wires bacterial recognition and Rac stimulation via a direct association with Vav to promote rapid phagocytosis and elimination of CEACAM-binding human pathogens.	ceacam	79-85	vav guanine nucleotide exchange factor 1	Homo sapiens	190-193
14707113-2	2004	Interestingly, human granulocytes express a specific isoform, CEACAM3, that participates together with CEACAM1 and CEACAM6 in the recognition of CEACAM-binding microorganisms.	ceacam	62-68	CEA cell adhesion molecule 1	Homo sapiens	103-110
16724098-3	2006	In this Review, we consider the evidence for CEACAM involvement in immunity, with a particular emphasis on CEACAM1, which functions as a regulatory co-receptor for both lymphoid and myeloid cell types.	ceacam	45-51	CEA cell adhesion molecule 1	Homo sapiens	107-114
16332726-6	2006	Studies of other members of the CEACAM family revealed that the re-expression in Hec1B carcinoma cells is restricted to CEACAM1 suggesting a cell type-specific and cell type-independent mechanism of CEACAM1 activation via the protein kinase C (PKC) pathway.	ceacam	32-38	NDC80 kinetochore complex component	Homo sapiens	81-85
16332726-6	2006	Studies of other members of the CEACAM family revealed that the re-expression in Hec1B carcinoma cells is restricted to CEACAM1 suggesting a cell type-specific and cell type-independent mechanism of CEACAM1 activation via the protein kinase C (PKC) pathway.	ceacam	32-38	CEA cell adhesion molecule 1	Homo sapiens	120-127
16332726-6	2006	Studies of other members of the CEACAM family revealed that the re-expression in Hec1B carcinoma cells is restricted to CEACAM1 suggesting a cell type-specific and cell type-independent mechanism of CEACAM1 activation via the protein kinase C (PKC) pathway.	ceacam	32-38	CEA cell adhesion molecule 1	Homo sapiens	199-206
15509546-6	2004	Treatment with anti-CEACAM monoclonal antibodies blocked CEACAM1-enhanced cell invasion and cell migration in a dose-dependent manner.	ceacam	20-26	CEA cell adhesion molecule 1	Homo sapiens	57-64
15130118-4	2004	We analysed the interactions of Afa/Dr DAEC with the CEACAMs using CEACAM-expressing CHO and HeLa cells.	ceacam	53-59	AFA	Homo sapiens	32-35
14707113-2	2004	Interestingly, human granulocytes express a specific isoform, CEACAM3, that participates together with CEACAM1 and CEACAM6 in the recognition of CEACAM-binding microorganisms.	ceacam	62-68	CEA cell adhesion molecule 6	Homo sapiens	115-122
11994468-10	2002	Support for the replacement hypothesis was obtained from experiments in which the extracellular signal-regulated kinases (Erk)1/2 were activated by anti-CEACAM Abs.	ceacam	153-159	mitogen-activated protein kinase 3	Homo sapiens	82-129
34442827-5	2021	Different gastric cancer cells were infected with the H. pylori wild type, or HopQ mutant strains, and the activation of non-canonical NF-kappaB was related to CEACAM expression levels.	ceacam	160-166	nuclear factor kappa B subunit 1	Homo sapiens	135-144
11751883-4	2002	We therefore characterized CEACAM expression in primary human ovarian surface epithelial (HOSE) cells and found that CEACAM1-3 (L, S) and CEACAM1-4 (L, S) splice variants mediate an increased Opa(52)-dependent gonoccocal binding to HOSE cells.	ceacam	27-33	CEA cell adhesion molecule 1	Homo sapiens	117-126
11751883-4	2002	We therefore characterized CEACAM expression in primary human ovarian surface epithelial (HOSE) cells and found that CEACAM1-3 (L, S) and CEACAM1-4 (L, S) splice variants mediate an increased Opa(52)-dependent gonoccocal binding to HOSE cells.	ceacam	27-33	CEA cell adhesion molecule 1	Homo sapiens	138-147
34442827-6	2021	The correlation between CEACAM levels and the activation of non-canonical NF-kappaB was confirmed in human gastric tissue samples.	ceacam	24-30	nuclear factor kappa B subunit 1	Homo sapiens	74-83
33361319-8	2020	These findings suggest that CEACAM upregulation could put patients at increased risk of lower respiratory tract infection by A. baumannii IMPORTANCE This work shows for the first time that Acinetobacter baumannii binds to carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), CEACAM5, and CEACAM6.	ceacam	28-34	CEA cell adhesion molecule 1	Homo sapiens	281-288
33361319-8	2020	These findings suggest that CEACAM upregulation could put patients at increased risk of lower respiratory tract infection by A. baumannii IMPORTANCE This work shows for the first time that Acinetobacter baumannii binds to carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), CEACAM5, and CEACAM6.	ceacam	28-34	CEA cell adhesion molecule 5	Homo sapiens	291-298
33361319-8	2020	These findings suggest that CEACAM upregulation could put patients at increased risk of lower respiratory tract infection by A. baumannii IMPORTANCE This work shows for the first time that Acinetobacter baumannii binds to carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), CEACAM5, and CEACAM6.	ceacam	28-34	CEA cell adhesion molecule 6	Homo sapiens	304-311
32019805-3	2020	Human and CEACAM-humanized mouse polymorphonuclear neutrophils (PMNs) allowed a specific HopQ-dependent interaction strongly enhancing CagA translocation.	ceacam	10-16	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	135-139
32019805-7	2020	Neutrophils, but not macrophages or DCs, from CEACAM-humanized mice, significantly upregulated the proinflammatory chemokine MIP-1alpha.	ceacam	46-52	chemokine (C-C motif) ligand 3	Mus musculus	125-135
32019805-17	2020	The H. pylori-CEACAM interaction modulates PMNs to reduce the H. pylori CagA translocation efficiency in vivo and to fine-tune the expression of CEACAM receptors on neutrophils to limit translocation of CagA and gastric pathology.	ceacam	14-20	S100 calcium binding protein A8	Homo sapiens	72-76
32019805-17	2020	The H. pylori-CEACAM interaction modulates PMNs to reduce the H. pylori CagA translocation efficiency in vivo and to fine-tune the expression of CEACAM receptors on neutrophils to limit translocation of CagA and gastric pathology.	ceacam	14-20	S100 calcium binding protein A8	Homo sapiens	203-207
32019805-8	2020	However, macrophages showed a significantly reduced amount of CXCL1 (KC) and CCL2 (MCP-1) secretion in CEACAM-humanized versus wt cells.	ceacam	103-109	C-X-C motif chemokine ligand 1	Homo sapiens	62-67
32019805-8	2020	However, macrophages showed a significantly reduced amount of CXCL1 (KC) and CCL2 (MCP-1) secretion in CEACAM-humanized versus wt cells.	ceacam	103-109	C-C motif chemokine ligand 2	Homo sapiens	77-81
32019805-8	2020	However, macrophages showed a significantly reduced amount of CXCL1 (KC) and CCL2 (MCP-1) secretion in CEACAM-humanized versus wt cells.	ceacam	103-109	C-C motif chemokine ligand 2	Homo sapiens	83-88
27171273-4	2016	The prototype of a CEACAM-binding pathogen, Neisseria gonorrhoeae, utilizes colony opacity associated (Opa) proteins to engage CEA, as well as the CEA-related cell adhesion molecules CEACAM1 and CEACAM6 on human epithelial cells.	ceacam	19-25	CEA cell adhesion molecule 3	Homo sapiens	127-130