PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25466967-4	2015	Affinity of TC to the uptake transporters OATP1A2, -1B1, -1B3, -2B1, OCT1, -2, -3, OCTN2, NTCP, and ASBT and the efflux carriers P-gp, MRP2 and MRP3 transfected in HEK293 and MDCK2 cells was measured.	trospium chloride	12-14	solute carrier organic anion transporter family member 1A2	Homo sapiens	42-49
28747995-1	2017	BACKGROUND: The objective of this study was to examine the inhibitory potential of darifenacin, fesoterodine, oxybutynin, propiverine, solifenacin, tolterodine and trospium chloride on the seven major human cytochrome P450 enzymes (CYP) by using a standardized and validated seven-in-one cytochrome P450 cocktail inhibition assay.	trospium chloride	164-181	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	207-222
28747995-1	2017	BACKGROUND: The objective of this study was to examine the inhibitory potential of darifenacin, fesoterodine, oxybutynin, propiverine, solifenacin, tolterodine and trospium chloride on the seven major human cytochrome P450 enzymes (CYP) by using a standardized and validated seven-in-one cytochrome P450 cocktail inhibition assay.	trospium chloride	164-181	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	288-303
25466967-4	2015	Affinity of TC to the uptake transporters OATP1A2, -1B1, -1B3, -2B1, OCT1, -2, -3, OCTN2, NTCP, and ASBT and the efflux carriers P-gp, MRP2 and MRP3 transfected in HEK293 and MDCK2 cells was measured.	trospium chloride	12-14	solute carrier family 22 member 1	Homo sapiens	69-73
25466967-4	2015	Affinity of TC to the uptake transporters OATP1A2, -1B1, -1B3, -2B1, OCT1, -2, -3, OCTN2, NTCP, and ASBT and the efflux carriers P-gp, MRP2 and MRP3 transfected in HEK293 and MDCK2 cells was measured.	trospium chloride	12-14	solute carrier family 22 member 5	Homo sapiens	83-88
25466967-4	2015	Affinity of TC to the uptake transporters OATP1A2, -1B1, -1B3, -2B1, OCT1, -2, -3, OCTN2, NTCP, and ASBT and the efflux carriers P-gp, MRP2 and MRP3 transfected in HEK293 and MDCK2 cells was measured.	trospium chloride	12-14	solute carrier family 10 member 1	Homo sapiens	90-94
25466967-4	2015	Affinity of TC to the uptake transporters OATP1A2, -1B1, -1B3, -2B1, OCT1, -2, -3, OCTN2, NTCP, and ASBT and the efflux carriers P-gp, MRP2 and MRP3 transfected in HEK293 and MDCK2 cells was measured.	trospium chloride	12-14	solute carrier family 10 member 2	Homo sapiens	100-104
25466967-4	2015	Affinity of TC to the uptake transporters OATP1A2, -1B1, -1B3, -2B1, OCT1, -2, -3, OCTN2, NTCP, and ASBT and the efflux carriers P-gp, MRP2 and MRP3 transfected in HEK293 and MDCK2 cells was measured.	trospium chloride	12-14	phosphoglycolate phosphatase	Homo sapiens	129-133
25466967-4	2015	Affinity of TC to the uptake transporters OATP1A2, -1B1, -1B3, -2B1, OCT1, -2, -3, OCTN2, NTCP, and ASBT and the efflux carriers P-gp, MRP2 and MRP3 transfected in HEK293 and MDCK2 cells was measured.	trospium chloride	12-14	ATP binding cassette subfamily C member 2	Homo sapiens	135-139
25466967-4	2015	Affinity of TC to the uptake transporters OATP1A2, -1B1, -1B3, -2B1, OCT1, -2, -3, OCTN2, NTCP, and ASBT and the efflux carriers P-gp, MRP2 and MRP3 transfected in HEK293 and MDCK2 cells was measured.	trospium chloride	12-14	ATP binding cassette subfamily C member 3	Homo sapiens	144-148
25466967-6	2015	TC was shown to be a substrate of OATP1A2 (Km = 6.9 +- 1.3 mumol/L; Vmax = 41.6 +- 1.8 pmol/mg min), OCT1 (Km = 106 +- 16 mumol/L; Vmax = 269 +- 18 pmol/mg min), and P-gp (Km = 34.9 +- 7.5 mumol/L; Vmax = 105 +- 9.1 pmol/mg min, lipovesicle assay).	trospium chloride	0-2	solute carrier organic anion transporter family member 1A2	Homo sapiens	34-41
25466967-6	2015	TC was shown to be a substrate of OATP1A2 (Km = 6.9 +- 1.3 mumol/L; Vmax = 41.6 +- 1.8 pmol/mg min), OCT1 (Km = 106 +- 16 mumol/L; Vmax = 269 +- 18 pmol/mg min), and P-gp (Km = 34.9 +- 7.5 mumol/L; Vmax = 105 +- 9.1 pmol/mg min, lipovesicle assay).	trospium chloride	0-2	solute carrier family 22 member 1	Homo sapiens	101-105
25466967-6	2015	TC was shown to be a substrate of OATP1A2 (Km = 6.9 +- 1.3 mumol/L; Vmax = 41.6 +- 1.8 pmol/mg min), OCT1 (Km = 106 +- 16 mumol/L; Vmax = 269 +- 18 pmol/mg min), and P-gp (Km = 34.9 +- 7.5 mumol/L; Vmax = 105 +- 9.1 pmol/mg min, lipovesicle assay).	trospium chloride	0-2	phosphoglycolate phosphatase	Homo sapiens	166-170
25466967-7	2015	The genetic OATP1A2 variants *2 and *3 were loss-of-function transporters for TC.	trospium chloride	78-80	solute carrier organic anion transporter family member 1A2	Homo sapiens	12-19
25466967-11	2015	TC was taken up into HBU cells (Km = 18.5 +- 4.8 mumol/L; Vmax = 106 +- 11.3 pmol/mg min) by mechanisms that could be synergistically inhibited by naringin (IC50 = 10.8 (8.4; 13.8) mumol/L) and verapamil (IC50 = 4.6 (2.8; 7.5) mumol/L), inhibitors of OATP1A2 and OCT1, respectively.	trospium chloride	0-2	solute carrier organic anion transporter family member 1A2	Homo sapiens	251-258
25466967-11	2015	TC was taken up into HBU cells (Km = 18.5 +- 4.8 mumol/L; Vmax = 106 +- 11.3 pmol/mg min) by mechanisms that could be synergistically inhibited by naringin (IC50 = 10.8 (8.4; 13.8) mumol/L) and verapamil (IC50 = 4.6 (2.8; 7.5) mumol/L), inhibitors of OATP1A2 and OCT1, respectively.	trospium chloride	0-2	solute carrier family 22 member 1	Homo sapiens	263-267
25466967-12	2015	Affinity of TC to OCT1 and P-glycoprotein may be the reason for incomplete oral absorption, wide distribution into liver and kidneys, and substantial intestinal and renal secretions.	trospium chloride	12-14	solute carrier family 22 member 1	Homo sapiens	18-22
25466967-12	2015	Affinity of TC to OCT1 and P-glycoprotein may be the reason for incomplete oral absorption, wide distribution into liver and kidneys, and substantial intestinal and renal secretions.	trospium chloride	12-14	ATP binding cassette subfamily B member 1	Homo sapiens	27-41
19389858-0	2009	The role of p-glycoprotein in limiting brain penetration of the peripherally acting anticholinergic overactive bladder drug trospium chloride.	trospium chloride	124-141	phosphoglycolate phosphatase	Mus musculus	12-26
19389858-1	2009	The aim of the present study was to characterize the role of the drug-efflux transporter P-glycoprotein (P-gp) for the disposition of trospium chloride, a widely used anticholinergic drug for the treatment of overactive bladder.	trospium chloride	134-151	phosphoglycolate phosphatase	Mus musculus	89-103
19389858-1	2009	The aim of the present study was to characterize the role of the drug-efflux transporter P-glycoprotein (P-gp) for the disposition of trospium chloride, a widely used anticholinergic drug for the treatment of overactive bladder.	trospium chloride	134-151	phosphoglycolate phosphatase	Mus musculus	105-109
19389858-3	2009	The concentrations of trospium chloride in the brain were up to 7 times higher in the mdr1a,b(-/-) knockout mice compared with wild-type mice (p < 0.05), making P-gp a limiting factor for the blood-brain barrier penetration of this drug.	trospium chloride	22-39	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	86-91
19389858-3	2009	The concentrations of trospium chloride in the brain were up to 7 times higher in the mdr1a,b(-/-) knockout mice compared with wild-type mice (p < 0.05), making P-gp a limiting factor for the blood-brain barrier penetration of this drug.	trospium chloride	22-39	phosphoglycolate phosphatase	Mus musculus	164-168
19389858-5	2009	Apart from the blood-brain barrier, P-gp also had significant effects on the overall pharmacokinetics of trospium chloride.	trospium chloride	105-122	phosphoglycolate phosphatase	Mus musculus	36-40
19389858-7	2009	Our study indicates that the multidrug resistance transporter P-gp is a major determinant for the distribution of trospium chloride in the body and highly restricts its entry into the brain.	trospium chloride	114-131	phosphoglycolate phosphatase	Mus musculus	62-66
16809803-3	2006	The effect of trospium chloride on human P-glycoprotein-mediated transport of [3H]-digoxin was determined in vitro.	trospium chloride	14-31	ATP binding cassette subfamily B member 1	Homo sapiens	41-55
10628907-10	1999	Thus, trospium chloride has negligible inhibitory effects on CYP3A4, CYP1A2, CYP2E1, CYP2C19, CYP2C9 and CYP2A6 activity but is a reasonably potent inhibitor of CYP2D6 in vitro.	trospium chloride	6-23	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	161-167
10628907-11	1999	Compared to therapeutic trospium chloride peak plasma concentrations below 50 nM, the 1000-times higher competitive inhibition constant Ki however suggests that inhibition of CYP2D6 by trospium chloride is without any clinical relevance.	trospium chloride	185-202	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	175-181
22120415-3	2013	METHODS: Trospium chloride at 1 mg/kg was intravenously administered to adult, middle-aged, and aged mice at 6, 12, and 24 months of age, respectively, and the absolute drug concentrations in the brain were analysed after 2 h. Furthermore, mRNA expression levels of relevant markers of blood-brain barrier integrity (occludin, claudin-5, and the drug efflux carrier P-glycoprotein) were analysed in brain samples from adult and aged mice.	trospium chloride	9-26	occludin	Mus musculus	317-325
22120415-3	2013	METHODS: Trospium chloride at 1 mg/kg was intravenously administered to adult, middle-aged, and aged mice at 6, 12, and 24 months of age, respectively, and the absolute drug concentrations in the brain were analysed after 2 h. Furthermore, mRNA expression levels of relevant markers of blood-brain barrier integrity (occludin, claudin-5, and the drug efflux carrier P-glycoprotein) were analysed in brain samples from adult and aged mice.	trospium chloride	9-26	claudin 5	Mus musculus	327-336
22120415-7	2013	CONCLUSION: Based on our in vivo data in a mouse model, we conclude that trospium chloride permeation across the BBB is not increased in ageing per se, and therefore, the occurrence of adverse CNS drug effects is also not expected to increase with ageing.	trospium chloride	73-90	ALMS1, centrosome and basal body associated	Mus musculus	113-116
33375004-4	2020	In humans, the organic cation transporters OCT1 and OCT2 and the multidrug and toxin extrusion MATE1 and MATE2-K carriers showed TCl transport.	trospium chloride	129-132	solute carrier family 22 member 1	Homo sapiens	43-47
33375004-4	2020	In humans, the organic cation transporters OCT1 and OCT2 and the multidrug and toxin extrusion MATE1 and MATE2-K carriers showed TCl transport.	trospium chloride	129-132	solute carrier family 22 member 2	Homo sapiens	52-56
33375004-4	2020	In humans, the organic cation transporters OCT1 and OCT2 and the multidrug and toxin extrusion MATE1 and MATE2-K carriers showed TCl transport.	trospium chloride	129-132	solute carrier family 47 member 1	Homo sapiens	95-100
33375004-4	2020	In humans, the organic cation transporters OCT1 and OCT2 and the multidrug and toxin extrusion MATE1 and MATE2-K carriers showed TCl transport.	trospium chloride	129-132	solute carrier family 47 member 2	Homo sapiens	105-112
33375004-6	2020	Knockout mouse models lacking mOct1/mOct2 or mMate1 might help to clarify their role for the overall pharmacokinetics of TCl.	trospium chloride	121-124	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	30-35
33375004-6	2020	Knockout mouse models lacking mOct1/mOct2 or mMate1 might help to clarify their role for the overall pharmacokinetics of TCl.	trospium chloride	121-124	solute carrier family 22 (organic cation transporter), member 2	Mus musculus	36-41
33375004-6	2020	Knockout mouse models lacking mOct1/mOct2 or mMate1 might help to clarify their role for the overall pharmacokinetics of TCl.	trospium chloride	121-124	solute carrier family 47, member 1	Mus musculus	45-51
33375004-7	2020	METHOD: In preparation of such experiments, TCl transport was analyzed in HEK293 cells stably transfected with the mouse carriers mOct1, mOct2, mMate1, and mMate2, respectively.	trospium chloride	44-47	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	130-135
33375004-7	2020	METHOD: In preparation of such experiments, TCl transport was analyzed in HEK293 cells stably transfected with the mouse carriers mOct1, mOct2, mMate1, and mMate2, respectively.	trospium chloride	44-47	solute carrier family 22 (organic cation transporter), member 2	Mus musculus	137-142
33375004-8	2020	RESULTS: Mouse mOct1, mOct2, and mMate1 showed significant TCl transport with Km values of 58.7, 78.5, and 29.3 microM, respectively.	trospium chloride	59-62	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	15-20
33375004-8	2020	RESULTS: Mouse mOct1, mOct2, and mMate1 showed significant TCl transport with Km values of 58.7, 78.5, and 29.3 microM, respectively.	trospium chloride	59-62	solute carrier family 22 (organic cation transporter), member 2	Mus musculus	22-27
33375004-8	2020	RESULTS: Mouse mOct1, mOct2, and mMate1 showed significant TCl transport with Km values of 58.7, 78.5, and 29.3 microM, respectively.	trospium chloride	59-62	solute carrier family 47, member 1	Mus musculus	33-39
33375004-9	2020	In contrast, mMate2 did not transport TCl but showed MPP+ transport with Km of 60.0 microM that was inhibited by the drugs topotecan, acyclovir, and levofloxacin.	trospium chloride	38-41	solute carrier family 47, member 2	Mus musculus	13-19