PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3841194-4	1985	Pretreatment with either antisera did not affect basal plasma PRL levels, whereas plasma PRL rises after ether exposure were significantly lower in rats pretreated with AVS, APS or AVS plus APS than those with NRS.	nicaraven	169-172	prolactin	Rattus norvegicus	89-92
33356884-0	2021	Nicaraven inhibits TNFalpha-induced endothelial activation and inflammation through suppressing NF-kappaB signaling pathway.	nicaraven	0-9	tumor necrosis factor	Homo sapiens	19-27
3876209-3	1985	Anti-VIP serum (AVS) and anti-PHI serum (APS), each generated in rabbits against synthetic porcine VIP and natural porcine PHI, respectively, were highly potent [maximum binding capacity (Bmax): AVS, 55.5 nmol/ml; APS, 5.53 nmol/ml] and specific.	nicaraven	16-19	VIP peptides	Oryctolagus cuniculus	5-8
3876209-3	1985	Anti-VIP serum (AVS) and anti-PHI serum (APS), each generated in rabbits against synthetic porcine VIP and natural porcine PHI, respectively, were highly potent [maximum binding capacity (Bmax): AVS, 55.5 nmol/ml; APS, 5.53 nmol/ml] and specific.	nicaraven	16-19	VIP peptides	Oryctolagus cuniculus	99-102
33356884-0	2021	Nicaraven inhibits TNFalpha-induced endothelial activation and inflammation through suppressing NF-kappaB signaling pathway.	nicaraven	0-9	nuclear factor kappa B subunit 1	Homo sapiens	96-105
33356884-4	2021	Here we investigated the effects of Nicaraven on TNFalpha-induced inflammatory response in human umbilical vein endothelial cells (HUVECs) and explore the underlying mechanisms related to NF-kappaB signaling pathway.	nicaraven	36-45	tumor necrosis factor	Homo sapiens	49-57
33356884-5	2021	Our results showed that Nicaraven significantly reduced the reactive oxygen species production after TNFalpha stimulation.	nicaraven	24-33	tumor necrosis factor	Homo sapiens	101-109
33356884-6	2021	Nicaraven suppressed TNFalpha-induced mRNA expression of multiple adhesion molecules and pro-inflammatory cytokines, including VCAM-1, ICAM-1, E-selectin, MCP-1, TNFalpha, IL-1beta, IL-6 and IL-8.	nicaraven	0-9	tumor necrosis factor	Homo sapiens	21-29
33356884-6	2021	Nicaraven suppressed TNFalpha-induced mRNA expression of multiple adhesion molecules and pro-inflammatory cytokines, including VCAM-1, ICAM-1, E-selectin, MCP-1, TNFalpha, IL-1beta, IL-6 and IL-8.	nicaraven	0-9	vascular cell adhesion molecule 1	Homo sapiens	127-133
33356884-6	2021	Nicaraven suppressed TNFalpha-induced mRNA expression of multiple adhesion molecules and pro-inflammatory cytokines, including VCAM-1, ICAM-1, E-selectin, MCP-1, TNFalpha, IL-1beta, IL-6 and IL-8.	nicaraven	0-9	intercellular adhesion molecule 1	Homo sapiens	135-141
33356884-6	2021	Nicaraven suppressed TNFalpha-induced mRNA expression of multiple adhesion molecules and pro-inflammatory cytokines, including VCAM-1, ICAM-1, E-selectin, MCP-1, TNFalpha, IL-1beta, IL-6 and IL-8.	nicaraven	0-9	selectin E	Homo sapiens	143-153
33356884-6	2021	Nicaraven suppressed TNFalpha-induced mRNA expression of multiple adhesion molecules and pro-inflammatory cytokines, including VCAM-1, ICAM-1, E-selectin, MCP-1, TNFalpha, IL-1beta, IL-6 and IL-8.	nicaraven	0-9	C-C motif chemokine ligand 2	Homo sapiens	155-160
33356884-6	2021	Nicaraven suppressed TNFalpha-induced mRNA expression of multiple adhesion molecules and pro-inflammatory cytokines, including VCAM-1, ICAM-1, E-selectin, MCP-1, TNFalpha, IL-1beta, IL-6 and IL-8.	nicaraven	0-9	tumor necrosis factor	Homo sapiens	162-170
33356884-6	2021	Nicaraven suppressed TNFalpha-induced mRNA expression of multiple adhesion molecules and pro-inflammatory cytokines, including VCAM-1, ICAM-1, E-selectin, MCP-1, TNFalpha, IL-1beta, IL-6 and IL-8.	nicaraven	0-9	interleukin 1 alpha	Homo sapiens	172-180
33356884-6	2021	Nicaraven suppressed TNFalpha-induced mRNA expression of multiple adhesion molecules and pro-inflammatory cytokines, including VCAM-1, ICAM-1, E-selectin, MCP-1, TNFalpha, IL-1beta, IL-6 and IL-8.	nicaraven	0-9	interleukin 6	Homo sapiens	182-186
33356884-6	2021	Nicaraven suppressed TNFalpha-induced mRNA expression of multiple adhesion molecules and pro-inflammatory cytokines, including VCAM-1, ICAM-1, E-selectin, MCP-1, TNFalpha, IL-1beta, IL-6 and IL-8.	nicaraven	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
33356884-7	2021	In addition, Nicaraven inhibited monocyte adhesion and reduced the protein levels of VCAM-1 and ICAM-1.	nicaraven	13-22	vascular cell adhesion molecule 1	Homo sapiens	85-91
33356884-7	2021	In addition, Nicaraven inhibited monocyte adhesion and reduced the protein levels of VCAM-1 and ICAM-1.	nicaraven	13-22	intercellular adhesion molecule 1	Homo sapiens	96-102
33356884-8	2021	Mechanistically, Nicaraven prevented TNFalpha-induced activation of NF-kappaB signaling pathway by suppressing the phosphorylation of NF-kappaB p65, IkappaBalpha, and IKKalpha/beta, stabilizing IkappaBalpha, and inhibiting the translocation of p65 from cytosol to nucleus.	nicaraven	17-26	tumor necrosis factor	Homo sapiens	37-45
33356884-8	2021	Mechanistically, Nicaraven prevented TNFalpha-induced activation of NF-kappaB signaling pathway by suppressing the phosphorylation of NF-kappaB p65, IkappaBalpha, and IKKalpha/beta, stabilizing IkappaBalpha, and inhibiting the translocation of p65 from cytosol to nucleus.	nicaraven	17-26	nuclear factor kappa B subunit 1	Homo sapiens	68-77
33356884-8	2021	Mechanistically, Nicaraven prevented TNFalpha-induced activation of NF-kappaB signaling pathway by suppressing the phosphorylation of NF-kappaB p65, IkappaBalpha, and IKKalpha/beta, stabilizing IkappaBalpha, and inhibiting the translocation of p65 from cytosol to nucleus.	nicaraven	17-26	RELA proto-oncogene, NF-kB subunit	Homo sapiens	134-147
33356884-8	2021	Mechanistically, Nicaraven prevented TNFalpha-induced activation of NF-kappaB signaling pathway by suppressing the phosphorylation of NF-kappaB p65, IkappaBalpha, and IKKalpha/beta, stabilizing IkappaBalpha, and inhibiting the translocation of p65 from cytosol to nucleus.	nicaraven	17-26	NFKB inhibitor alpha	Homo sapiens	149-161
33356884-8	2021	Mechanistically, Nicaraven prevented TNFalpha-induced activation of NF-kappaB signaling pathway by suppressing the phosphorylation of NF-kappaB p65, IkappaBalpha, and IKKalpha/beta, stabilizing IkappaBalpha, and inhibiting the translocation of p65 from cytosol to nucleus.	nicaraven	17-26	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	167-180
33356884-8	2021	Mechanistically, Nicaraven prevented TNFalpha-induced activation of NF-kappaB signaling pathway by suppressing the phosphorylation of NF-kappaB p65, IkappaBalpha, and IKKalpha/beta, stabilizing IkappaBalpha, and inhibiting the translocation of p65 from cytosol to nucleus.	nicaraven	17-26	NFKB inhibitor alpha	Homo sapiens	194-206
33356884-8	2021	Mechanistically, Nicaraven prevented TNFalpha-induced activation of NF-kappaB signaling pathway by suppressing the phosphorylation of NF-kappaB p65, IkappaBalpha, and IKKalpha/beta, stabilizing IkappaBalpha, and inhibiting the translocation of p65 from cytosol to nucleus.	nicaraven	17-26	RELA proto-oncogene, NF-kB subunit	Homo sapiens	144-147
33356884-9	2021	Finally, we showed that Nicaraven improved the functions of endothelial cells, seen as the up-regulation of endothelial nitric oxide synthase and increased nitric oxide levels.	nicaraven	24-33	nitric oxide synthase 3	Homo sapiens	108-141
33356884-10	2021	Our findings indicated that Nicaraven effectively inhibits TNFalpha-induced endothelial activation and inflammatory response at least partly through inhibiting NF-kappaB signaling pathway.	nicaraven	28-37	tumor necrosis factor	Homo sapiens	59-67
33356884-10	2021	Our findings indicated that Nicaraven effectively inhibits TNFalpha-induced endothelial activation and inflammatory response at least partly through inhibiting NF-kappaB signaling pathway.	nicaraven	28-37	nuclear factor kappa B subunit 1	Homo sapiens	160-169
21325453-10	2011	Accordingly, only 53% of AVS were bilaterally selective using the selectivity index determined with ChA, as compared to 84% with selectivity index determined with cortisol (P = 0.0001).	nicaraven	25-28	chromogranin A	Homo sapiens	100-103
31873930-7	2020	Immunostaining indicated the increase of Ly6g-, CD206-, and CD11c-positive inflammatory cells in the lungs, but it was also attenuated by nicaraven administration.	nicaraven	138-147	integrin subunit alpha X	Homo sapiens	60-65
29339207-0	2018	Nicaraven reduces cancer metastasis to irradiated lungs by decreasing CCL8 and macrophage recruitment.	nicaraven	0-9	chemokine (C-C motif) ligand 8	Mus musculus	70-74
29339207-6	2018	Furthermore, nicaraven administration effectively inhibited CCL8 expression and macrophage recruitment in the lungs 1 day after thorax irradiation.	nicaraven	13-22	chemokine (C-C motif) ligand 8	Mus musculus	60-64
25529494-4	2015	In 3 weeks of bioremediation treatment, the injection of microemulsion and NO3 (-) seems to have delayed the autotrophic denitrification between NO3 (-) and acid volatile sulfide (AVS) in sediment compared to the control with NO3 (-) injection alone.	nicaraven	180-183	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
25173934-6	2014	Nicaraven increased the number of c-kit(+) stem/progenitor cells in bone marrow and peripheral blood, with a recovery rate around 60-90% of age-matched non-irradiated healthy mice.	nicaraven	0-9	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	34-39
25173934-8	2014	Furthermore, nicaraven treatment changed the expression of many genes associated to DNA repair, inflammatory response, and immunomodulation in c-kit(+) stem/progenitor cells.	nicaraven	13-22	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	143-148
23555869-7	2013	Interestingly, compared with the placebo treatment, the administration of nicaraven significantly decreased the levels of the inflammatory cytokines IL-6 and TNF-alpha in the plasma of mice.	nicaraven	74-83	interleukin 6	Mus musculus	149-153
23555869-7	2013	Interestingly, compared with the placebo treatment, the administration of nicaraven significantly decreased the levels of the inflammatory cytokines IL-6 and TNF-alpha in the plasma of mice.	nicaraven	74-83	tumor necrosis factor	Mus musculus	158-167
19686725-0	2009	Synergistic induction of heme oxygenase-1 by nicaraven after subarachnoid hemorrhage to prevent delayed cerebral vasospasm.	nicaraven	45-54	heme oxygenase 1	Homo sapiens	25-41
19686725-4	2009	of nicaraven (1 mg/kg/min, for 2 days after subarachnoid hemorrhage) ameliorated delayed cerebral vasospasm in rat subarachnoid hemorrhage models, marked synergistic induction of HO-1 protein (> 2.5-fold than "subarachnoid hemorrhage with saline i.v.	nicaraven	3-12	heme oxygenase 1	Rattus norvegicus	179-183
19686725-7	2009	Antisense HO-1 oligodeoxynucleotides abrogated this HO-1 induction and the antivasospastic effect of nicaraven.	nicaraven	101-110	heme oxygenase 1	Homo sapiens	10-14
19686725-8	2009	In vitro study using Hela cells, nicaraven enhanced the human HO-1 promoter (-4.5 kbp) activity, which was pre-activated with the blood component oxyhemoglobin to mimic the ability of subarachnoid hemorrhage.	nicaraven	33-42	heme oxygenase 1	Homo sapiens	62-66
17094462-4	2006	In addition to the hydroxyl radical scavenging effect, nicaraven also exhibits inhibitory action on poly (ADP-ribose) polymerase (PARP).	nicaraven	55-64	poly(ADP-ribose) polymerase 1	Homo sapiens	130-134
19746843-3	2009	Furthermore, we found that AVS-1357 induced prolonged activation of extracellular signal-regulated kinase (ERK) and Akt, while it downregulated microphthalmia-associated transcription factor (MITF) and tyrosinase.	nicaraven	27-30	mitogen-activated protein kinase 1	Homo sapiens	68-105
19746843-3	2009	Furthermore, we found that AVS-1357 induced prolonged activation of extracellular signal-regulated kinase (ERK) and Akt, while it downregulated microphthalmia-associated transcription factor (MITF) and tyrosinase.	nicaraven	27-30	mitogen-activated protein kinase 1	Homo sapiens	107-110
19746843-3	2009	Furthermore, we found that AVS-1357 induced prolonged activation of extracellular signal-regulated kinase (ERK) and Akt, while it downregulated microphthalmia-associated transcription factor (MITF) and tyrosinase.	nicaraven	27-30	AKT serine/threonine kinase 1	Homo sapiens	116-119
19746843-3	2009	Furthermore, we found that AVS-1357 induced prolonged activation of extracellular signal-regulated kinase (ERK) and Akt, while it downregulated microphthalmia-associated transcription factor (MITF) and tyrosinase.	nicaraven	27-30	melanocyte inducing transcription factor	Homo sapiens	144-190
19746843-3	2009	Furthermore, we found that AVS-1357 induced prolonged activation of extracellular signal-regulated kinase (ERK) and Akt, while it downregulated microphthalmia-associated transcription factor (MITF) and tyrosinase.	nicaraven	27-30	melanocyte inducing transcription factor	Homo sapiens	192-196
19746843-3	2009	Furthermore, we found that AVS-1357 induced prolonged activation of extracellular signal-regulated kinase (ERK) and Akt, while it downregulated microphthalmia-associated transcription factor (MITF) and tyrosinase.	nicaraven	27-30	tyrosinase	Homo sapiens	202-212
19746843-7	2009	Furthermore, PD98059 attenuated AVS-1357 induced ERK activation, as well as the downregulation of MITF and tyrosinase.	nicaraven	32-35	mitogen-activated protein kinase 1	Homo sapiens	49-52
19746843-8	2009	These findings suggest that the effects of AVS-1357 occur via downregulation of MITF and tyrosinase, which is caused by AVS-1357-induced prolonged ERK activation.	nicaraven	43-46	melanocyte inducing transcription factor	Homo sapiens	80-84
19746843-8	2009	These findings suggest that the effects of AVS-1357 occur via downregulation of MITF and tyrosinase, which is caused by AVS-1357-induced prolonged ERK activation.	nicaraven	43-46	tyrosinase	Homo sapiens	89-99
19746843-8	2009	These findings suggest that the effects of AVS-1357 occur via downregulation of MITF and tyrosinase, which is caused by AVS-1357-induced prolonged ERK activation.	nicaraven	43-46	mitogen-activated protein kinase 1	Homo sapiens	147-150
19746843-8	2009	These findings suggest that the effects of AVS-1357 occur via downregulation of MITF and tyrosinase, which is caused by AVS-1357-induced prolonged ERK activation.	nicaraven	120-123	melanocyte inducing transcription factor	Homo sapiens	80-84
19746843-8	2009	These findings suggest that the effects of AVS-1357 occur via downregulation of MITF and tyrosinase, which is caused by AVS-1357-induced prolonged ERK activation.	nicaraven	120-123	tyrosinase	Homo sapiens	89-99
19746843-8	2009	These findings suggest that the effects of AVS-1357 occur via downregulation of MITF and tyrosinase, which is caused by AVS-1357-induced prolonged ERK activation.	nicaraven	120-123	mitogen-activated protein kinase 1	Homo sapiens	147-150
17094462-0	2006	Inhibition of poly (ADP-ribose) polymerase as a protective effect of nicaraven in ionizing radiation- and ara-C-induced cell death.	nicaraven	69-78	poly(ADP-ribose) polymerase 1	Homo sapiens	14-42
17094462-4	2006	In addition to the hydroxyl radical scavenging effect, nicaraven also exhibits inhibitory action on poly (ADP-ribose) polymerase (PARP).	nicaraven	55-64	poly(ADP-ribose) polymerase 1	Homo sapiens	100-128
17094462-6	2006	MATERIALS AND METHODS: Human myeloid HL-525 cells were exposed to ionizing radiation or hydrogen peroxide and the effect of nicaraven on the activation of the Egr-1 promoter was measured.	nicaraven	124-133	early growth response 1	Homo sapiens	159-164
17094462-8	2006	Finally, direct inhibition of the PARP enzyme by nicaraven was measured.	nicaraven	49-58	poly(ADP-ribose) polymerase 1	Homo sapiens	34-38
17094462-11	2006	Nicaraven had a direct inhibitory effect on PARP.	nicaraven	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	44-48
17094462-12	2006	DISCUSSION: The effect of nicaraven on the Egr-1 promoter was different from that of another free-radical scavenger, N-acetyl cysteine.	nicaraven	26-35	early growth response 1	Homo sapiens	43-48
17094462-13	2006	Nicaraven demonstrated similar protection of the PARP inhibitors including 3-aminobenzamide.	nicaraven	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	49-53
17094462-14	2006	Since nicaraven directly inhibits the PARP enzyme, the drug might be useful in oncology as well as in studying tissue-damaging conditions characterized by increased PARP activity.	nicaraven	6-15	poly(ADP-ribose) polymerase 1	Homo sapiens	38-42
17094462-14	2006	Since nicaraven directly inhibits the PARP enzyme, the drug might be useful in oncology as well as in studying tissue-damaging conditions characterized by increased PARP activity.	nicaraven	6-15	poly(ADP-ribose) polymerase 1	Homo sapiens	165-169
10840362-9	2000	Nicaraven inhibited lipid peroxidation in the liver, improved hepatic and systemic hemodynamics and energy metabolism, and suppressed liver enzyme release, endothelin-1 elevation in hepatic venous blood, histologic damage, and neutrophil infiltration into the liver.	nicaraven	0-9	endothelin 1	Canis lupus familiaris	156-168
34999842-0	2022	Nicaraven mitigates radiation-induced lung injury by downregulating the NF-kappaB and TGF-beta/Smad pathways to suppress the inflammatory response.	nicaraven	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	72-81
34999842-0	2022	Nicaraven mitigates radiation-induced lung injury by downregulating the NF-kappaB and TGF-beta/Smad pathways to suppress the inflammatory response.	nicaraven	0-9	transforming growth factor alpha	Mus musculus	86-94
34999842-7	2022	Western blot analysis showed that nicaraven administration effectively attenuated the radiation-induced upregulation of NF-kappaB, TGF-beta, and pSmad2 in lungs.	nicaraven	34-43	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-129
34999842-7	2022	Western blot analysis showed that nicaraven administration effectively attenuated the radiation-induced upregulation of NF-kappaB, TGF-beta, and pSmad2 in lungs.	nicaraven	34-43	transforming growth factor alpha	Mus musculus	131-139
34999842-8	2022	Of the chronic phase, nicaraven administration effectively attenuated the radiation-induced enhancement of alpha-SMA expression and collagen deposition in lungs.	nicaraven	22-31	actin alpha 2, smooth muscle, aorta	Mus musculus	107-116
34999842-9	2022	In conclusion we find that nicaraven can effectively mitigate RILI by downregulating NF-kappaB and TGF-beta/pSmad2 pathways to suppress the inflammatory response in the irradiated lungs.	nicaraven	27-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	85-94
34999842-9	2022	In conclusion we find that nicaraven can effectively mitigate RILI by downregulating NF-kappaB and TGF-beta/pSmad2 pathways to suppress the inflammatory response in the irradiated lungs.	nicaraven	27-36	transforming growth factor alpha	Mus musculus	99-107
12897815-8	2003	Since nicaraven has an inhibitory effect in PARS, as well as a radical scavenging effect, these results suggest that inhibition of hippocampal cell death caused by NMDA may be attributable to PARS inhibition by nicaraven.	nicaraven	6-15	poly(ADP-ribose) polymerase 1	Homo sapiens	44-48
12897815-8	2003	Since nicaraven has an inhibitory effect in PARS, as well as a radical scavenging effect, these results suggest that inhibition of hippocampal cell death caused by NMDA may be attributable to PARS inhibition by nicaraven.	nicaraven	6-15	poly(ADP-ribose) polymerase 1	Homo sapiens	192-196
12897815-8	2003	Since nicaraven has an inhibitory effect in PARS, as well as a radical scavenging effect, these results suggest that inhibition of hippocampal cell death caused by NMDA may be attributable to PARS inhibition by nicaraven.	nicaraven	211-220	poly(ADP-ribose) polymerase 1	Homo sapiens	192-196
8337113-1	1993	In the present study, firstly the antioxidant effect of Nicaraven was observed by examining the direct free radical scavenging effect with ESR.	nicaraven	56-65	esterase 5 regulator	Mus musculus	139-142
34761342-5	2021	Cytokines/chemokines array indicated that nicaraven reduced the levels of CXCL10 and SDF-1 in the tumor as well as the levels of IL-2 and MIP-2 in serum.	nicaraven	42-51	chemokine (C-X-C motif) ligand 10	Mus musculus	74-80
34761342-5	2021	Cytokines/chemokines array indicated that nicaraven reduced the levels of CXCL10 and SDF-1 in the tumor as well as the levels of IL-2 and MIP-2 in serum.	nicaraven	42-51	chemokine (C-X-C motif) ligand 12	Mus musculus	85-90
34761342-5	2021	Cytokines/chemokines array indicated that nicaraven reduced the levels of CXCL10 and SDF-1 in the tumor as well as the levels of IL-2 and MIP-2 in serum.	nicaraven	42-51	interleukin 2	Mus musculus	129-133
34761342-5	2021	Cytokines/chemokines array indicated that nicaraven reduced the levels of CXCL10 and SDF-1 in the tumor as well as the levels of IL-2 and MIP-2 in serum.	nicaraven	42-51	chemokine (C-X-C motif) ligand 2	Mus musculus	138-143
34761342-7	2021	Interestingly, western blot indicated that the expression of CD86, CD206, and NIMP-R14 was especially enhanced in the three large-size tumors, suggesting the potential role of nicaraven in preventing the hyper-inflammatory tumor microenvironment.	nicaraven	176-185	CD86 antigen	Mus musculus	61-65
34761342-7	2021	Interestingly, western blot indicated that the expression of CD86, CD206, and NIMP-R14 was especially enhanced in the three large-size tumors, suggesting the potential role of nicaraven in preventing the hyper-inflammatory tumor microenvironment.	nicaraven	176-185	mannose receptor, C type 1	Mus musculus	67-72
34761342-8	2021	Moreover, the expression of PARP-1 was downregulated, but the expression of phospho-p38 MAPK, phospho-MKK-3/6, and phospho-MSK-1 was upregulated in the large-size tumors, suggesting the involvement of p38 MAPK pathway in the anti-inflammatory effect of nicaraven.	nicaraven	253-262	poly (ADP-ribose) polymerase family, member 1	Mus musculus	28-34
34761342-8	2021	Moreover, the expression of PARP-1 was downregulated, but the expression of phospho-p38 MAPK, phospho-MKK-3/6, and phospho-MSK-1 was upregulated in the large-size tumors, suggesting the involvement of p38 MAPK pathway in the anti-inflammatory effect of nicaraven.	nicaraven	253-262	mitogen-activated protein kinase 14	Mus musculus	84-92
34761342-8	2021	Moreover, the expression of PARP-1 was downregulated, but the expression of phospho-p38 MAPK, phospho-MKK-3/6, and phospho-MSK-1 was upregulated in the large-size tumors, suggesting the involvement of p38 MAPK pathway in the anti-inflammatory effect of nicaraven.	nicaraven	253-262	mitogen-activated protein kinase kinase 3	Mus musculus	102-109
34761342-8	2021	Moreover, the expression of PARP-1 was downregulated, but the expression of phospho-p38 MAPK, phospho-MKK-3/6, and phospho-MSK-1 was upregulated in the large-size tumors, suggesting the involvement of p38 MAPK pathway in the anti-inflammatory effect of nicaraven.	nicaraven	253-262	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	123-128
34761342-8	2021	Moreover, the expression of PARP-1 was downregulated, but the expression of phospho-p38 MAPK, phospho-MKK-3/6, and phospho-MSK-1 was upregulated in the large-size tumors, suggesting the involvement of p38 MAPK pathway in the anti-inflammatory effect of nicaraven.	nicaraven	253-262	mitogen-activated protein kinase 14	Mus musculus	201-209