PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26631141-8	2016	UMR106 cell Fgf23 transcripts were increased by stimulation of SOCE and Ca(2+) ionophore ionomycin and decreased by Orai inhibitors 2-APB, YM58483 and SK&F96365, by Orai1 silencing, as well as by NFkappaB inhibitors wogonin, withaferin A, and CAS 545380-34-5.	amicloral	151-157	fibroblast growth factor 23	Rattus norvegicus	12-17
26631141-8	2016	UMR106 cell Fgf23 transcripts were increased by stimulation of SOCE and Ca(2+) ionophore ionomycin and decreased by Orai inhibitors 2-APB, YM58483 and SK&F96365, by Orai1 silencing, as well as by NFkappaB inhibitors wogonin, withaferin A, and CAS 545380-34-5.	amicloral	151-157	ORAI calcium release-activated calcium modulator 1	Rattus norvegicus	169-174
24630903-6	2014	[Ca(2+)]i and secretory responses to 2-APB at pH 6.5 were inhibited by the removal of extracellular Ca(2+) and SOC channel blockers such as SK&F96365, La(3+) and Gd(3+).	amicloral	140-146	arginyl aminopeptidase	Rattus norvegicus	39-42
25218985-10	2014	Only nifedipine and SK&F 96365 relaxed the arteries pre-contracted with endothelin-1.	amicloral	20-26	endothelin 1	Rattus norvegicus	76-88
21767581-0	2011	SK&F 96365 induces apoptosis and autophagy by inhibiting Akt-mTOR signaling in A7r5 cells.	amicloral	0-6	AKT serine/threonine kinase 1	Rattus norvegicus	61-64
23347013-5	2013	M-3M3FBS-induced Ca2 + influx was inhibited by nifedipine, econazole, SK&F96365, aristolochic acid, and GF109203X.	amicloral	70-76	carbonic anhydrase 2	Homo sapiens	17-20
22212354-0	2012	Calcium influx blocked by SK&F 96365 modulates the LPS plus IFN-gamma-induced inflammatory response in murine peritoneal macrophages.	amicloral	26-32	toll-like receptor 4	Mus musculus	55-58
22212354-0	2012	Calcium influx blocked by SK&F 96365 modulates the LPS plus IFN-gamma-induced inflammatory response in murine peritoneal macrophages.	amicloral	26-32	interferon gamma	Mus musculus	64-73
22212354-4	2012	Phagocytosis analyzing results showed that SK&F 96365 efficiently diminished the uptake of nonopsonized 1 muM yellow-green beads or pHrodo -labeled Escherichia coli bacteria both on the resting and LPS plus IFN-gamma-stimulated macrophages.	amicloral	43-49	toll-like receptor 4	Mus musculus	202-205
22212354-4	2012	Phagocytosis analyzing results showed that SK&F 96365 efficiently diminished the uptake of nonopsonized 1 muM yellow-green beads or pHrodo -labeled Escherichia coli bacteria both on the resting and LPS plus IFN-gamma-stimulated macrophages.	amicloral	43-49	interferon gamma	Mus musculus	211-220
22212354-6	2012	The CBA analyzing results showed that SK&F 96365 pretreatment efficiently inhibited the production of LPS plus IFN-gamma-induced inflammatory cytokines of IL-6, MCP-1, TNF, INF-gamma, and IL-10.	amicloral	38-44	toll-like receptor 4	Mus musculus	106-109
22212354-6	2012	The CBA analyzing results showed that SK&F 96365 pretreatment efficiently inhibited the production of LPS plus IFN-gamma-induced inflammatory cytokines of IL-6, MCP-1, TNF, INF-gamma, and IL-10.	amicloral	38-44	interferon gamma	Mus musculus	115-124
22212354-6	2012	The CBA analyzing results showed that SK&F 96365 pretreatment efficiently inhibited the production of LPS plus IFN-gamma-induced inflammatory cytokines of IL-6, MCP-1, TNF, INF-gamma, and IL-10.	amicloral	38-44	interleukin 6	Mus musculus	159-163
22212354-6	2012	The CBA analyzing results showed that SK&F 96365 pretreatment efficiently inhibited the production of LPS plus IFN-gamma-induced inflammatory cytokines of IL-6, MCP-1, TNF, INF-gamma, and IL-10.	amicloral	38-44	mast cell protease 1	Mus musculus	165-170
22212354-6	2012	The CBA analyzing results showed that SK&F 96365 pretreatment efficiently inhibited the production of LPS plus IFN-gamma-induced inflammatory cytokines of IL-6, MCP-1, TNF, INF-gamma, and IL-10.	amicloral	38-44	tumor necrosis factor	Mus musculus	172-175
22212354-6	2012	The CBA analyzing results showed that SK&F 96365 pretreatment efficiently inhibited the production of LPS plus IFN-gamma-induced inflammatory cytokines of IL-6, MCP-1, TNF, INF-gamma, and IL-10.	amicloral	38-44	interleukin 10	Mus musculus	177-197
22212354-8	2012	Furthermore, SK&F 96365 pretreatment inhibited the LPS plus IFN-gamma-induced translocation of NF-kappaB to the nucleus, and induced a decrease in mitochondrial membrane potential (DeltaPsim) in LPS plus IFN-gamma-activated macrophages.	amicloral	13-19	toll-like receptor 4	Mus musculus	55-58
22212354-8	2012	Furthermore, SK&F 96365 pretreatment inhibited the LPS plus IFN-gamma-induced translocation of NF-kappaB to the nucleus, and induced a decrease in mitochondrial membrane potential (DeltaPsim) in LPS plus IFN-gamma-activated macrophages.	amicloral	13-19	interferon gamma	Mus musculus	64-73
22212354-8	2012	Furthermore, SK&F 96365 pretreatment inhibited the LPS plus IFN-gamma-induced translocation of NF-kappaB to the nucleus, and induced a decrease in mitochondrial membrane potential (DeltaPsim) in LPS plus IFN-gamma-activated macrophages.	amicloral	13-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
22212354-8	2012	Furthermore, SK&F 96365 pretreatment inhibited the LPS plus IFN-gamma-induced translocation of NF-kappaB to the nucleus, and induced a decrease in mitochondrial membrane potential (DeltaPsim) in LPS plus IFN-gamma-activated macrophages.	amicloral	13-19	toll-like receptor 4	Mus musculus	199-202
22212354-8	2012	Furthermore, SK&F 96365 pretreatment inhibited the LPS plus IFN-gamma-induced translocation of NF-kappaB to the nucleus, and induced a decrease in mitochondrial membrane potential (DeltaPsim) in LPS plus IFN-gamma-activated macrophages.	amicloral	13-19	interferon gamma	Mus musculus	208-217
22474110-7	2012	Coadministration of SOC inhibitors SK&F96365 or Gd3+ with E2/P4 also suppressed the up-regulation of IGFBP-1 and hESC size increase.	amicloral	35-41	insulin like growth factor binding protein 1	Homo sapiens	105-112
21767581-0	2011	SK&F 96365 induces apoptosis and autophagy by inhibiting Akt-mTOR signaling in A7r5 cells.	amicloral	0-6	mechanistic target of rapamycin kinase	Rattus norvegicus	65-69
21767581-5	2011	In addition, we found that SK&F 96365 inhibits Akt-mTOR signaling pathways, which is comparable with the efficacy of other known Akt inhibitors.	amicloral	27-33	AKT serine/threonine kinase 1	Rattus norvegicus	51-54
21767581-5	2011	In addition, we found that SK&F 96365 inhibits Akt-mTOR signaling pathways, which is comparable with the efficacy of other known Akt inhibitors.	amicloral	27-33	mechanistic target of rapamycin kinase	Rattus norvegicus	55-59
21767581-5	2011	In addition, we found that SK&F 96365 inhibits Akt-mTOR signaling pathways, which is comparable with the efficacy of other known Akt inhibitors.	amicloral	27-33	AKT serine/threonine kinase 1	Rattus norvegicus	133-136
21470712-6	2011	Upon the same stimulation, SK&F 96365 inhibited the expression of CD69 and CD25 on CD3+ T lymphocytes in a dose-dependent manner.	amicloral	27-33	CD69 antigen	Mus musculus	70-74
22135909-5	2011	Paroxetine-induced Ca2+ influx was inhibited by the store-operated Ca2+ channel blockers nifedipine, econazole and SK&F96365, and protein kinase C modulators.	amicloral	115-121	carbonic anhydrase 2	Homo sapiens	19-22
22135909-5	2011	Paroxetine-induced Ca2+ influx was inhibited by the store-operated Ca2+ channel blockers nifedipine, econazole and SK&F96365, and protein kinase C modulators.	amicloral	115-121	carbonic anhydrase 2	Homo sapiens	67-70
21770746-6	2011	This Ca(2+) influx was inhibited by phospholipase A2 inhibitor aristolochic acid, store-operated Ca(2+) channel blockers nifedipine and SK&F96365, and protein kinase C inhibitor GF109203X.	amicloral	136-142	phospholipase A2 group IB	Canis lupus familiaris	36-52
21470712-6	2011	Upon the same stimulation, SK&F 96365 inhibited the expression of CD69 and CD25 on CD3+ T lymphocytes in a dose-dependent manner.	amicloral	27-33	interleukin 2 receptor, alpha chain	Mus musculus	79-83
21470712-9	2011	Furthermore, SK&F 96365 significantly inhibited the production of proinflammatory cytokines (interferon (IFN)-gamma and tumor necrosis factor (TNF)), and the anti-inflammatory cytokine (IL-10) on both Con A- and PMA/ionomycin-activated lymphocytes.	amicloral	13-19	interferon gamma	Mus musculus	97-119
21470712-9	2011	Furthermore, SK&F 96365 significantly inhibited the production of proinflammatory cytokines (interferon (IFN)-gamma and tumor necrosis factor (TNF)), and the anti-inflammatory cytokine (IL-10) on both Con A- and PMA/ionomycin-activated lymphocytes.	amicloral	13-19	tumor necrosis factor	Mus musculus	124-145
21470712-9	2011	Furthermore, SK&F 96365 significantly inhibited the production of proinflammatory cytokines (interferon (IFN)-gamma and tumor necrosis factor (TNF)), and the anti-inflammatory cytokine (IL-10) on both Con A- and PMA/ionomycin-activated lymphocytes.	amicloral	13-19	tumor necrosis factor	Mus musculus	147-150
21470712-9	2011	Furthermore, SK&F 96365 significantly inhibited the production of proinflammatory cytokines (interferon (IFN)-gamma and tumor necrosis factor (TNF)), and the anti-inflammatory cytokine (IL-10) on both Con A- and PMA/ionomycin-activated lymphocytes.	amicloral	13-19	interleukin 10	Mus musculus	190-195
18436303-8	2008	2-APB and SK&F 96365 were able to amplify the reduction of fMLF-stimulated Ca(2+) entry and H(2)O(2) production observed in cells transfected by TRPC3 siRNA.	amicloral	10-16	transient receptor potential cation channel subfamily C member 3	Homo sapiens	149-154
21778596-6	2011	SK&F96365, a TRPC channel blocker, decreased the number of PVC and prevented VT in anesthetized Galpha(q)-TG mice (P<0.05).	amicloral	0-6	guanine nucleotide binding protein, alpha q polypeptide	Mus musculus	100-109
21778596-8	2011	SK&F96365 decreased the number of PVC and prevented VT in isolated Galpha(q)-TG hearts (P<0.01) even in the presence of OAG.	amicloral	0-6	guanine nucleotide binding protein, alpha q polypeptide	Mus musculus	71-80
20584631-6	2010	Interestingly, selective inhibition of p38 by either SB203580 or SK&F 86002 resulted in augmented IL-2 production by DN32.D3 cells after stimulation with alpha GC.	amicloral	65-71	mitogen-activated protein kinase 14	Mus musculus	39-42
20584631-6	2010	Interestingly, selective inhibition of p38 by either SB203580 or SK&F 86002 resulted in augmented IL-2 production by DN32.D3 cells after stimulation with alpha GC.	amicloral	65-71	interleukin 2	Mus musculus	102-106
21793331-3	2010	This Ca2+ influx was inhibited by phospholipase A2 inhibitor aristolochic acid but not by Ca2+ channel blockers such as nifedipine, nimodipine, nicardipine, diltiazem, verapamil, econazole and SK&F96365.	amicloral	193-199	phospholipase A2 group IB	Canis lupus familiaris	34-50
19317445-1	2009	3-(1H-Imidazol-4-yl)propylguanidine (SK&F 91486, 4) was identified as a potent partial agonist at the human histamine H(3) receptor (hH(3)R) and human histamine H(4) receptor (hH(4)R).	amicloral	37-43	histamine receptor H3	Homo sapiens	112-135
19317445-1	2009	3-(1H-Imidazol-4-yl)propylguanidine (SK&F 91486, 4) was identified as a potent partial agonist at the human histamine H(3) receptor (hH(3)R) and human histamine H(4) receptor (hH(4)R).	amicloral	37-43	histamine receptor H3	Homo sapiens	137-144
19317445-1	2009	3-(1H-Imidazol-4-yl)propylguanidine (SK&F 91486, 4) was identified as a potent partial agonist at the human histamine H(3) receptor (hH(3)R) and human histamine H(4) receptor (hH(4)R).	amicloral	37-43	histamine receptor H4	Homo sapiens	155-178
19317445-1	2009	3-(1H-Imidazol-4-yl)propylguanidine (SK&F 91486, 4) was identified as a potent partial agonist at the human histamine H(3) receptor (hH(3)R) and human histamine H(4) receptor (hH(4)R).	amicloral	37-43	histamine receptor H4	Homo sapiens	180-186
17845018-4	2007	These large inhibitors are not predicted to bind in that they protrude through the accessible surface calculated from a PNMT/7-aminosulfonyl-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) crystal structure, yet they are potent inhibitors of PNMT.	amicloral	173-179	phenylethanolamine N-methyltransferase	Homo sapiens	120-124
18243160-6	2008	The FcepsilonRIbeta ITAM was essential for overall calcium response upon weak FcepsilonRI stimulation (at low antigen concentration), while upon strong stimulation (at high antigen concentration) it appeared necessary selectively to an immediate calcium response that was sensitive to the dihydropyridine receptor (DHPR) antagonist nifedipine and wortmannin but not to the store-operated calcium entry (SOCE) antagonists such as 2-aminoethoxyphenyl borate and SK&F96365.	amicloral	460-466	Fc epsilon receptor Ia	Homo sapiens	4-15
18243160-6	2008	The FcepsilonRIbeta ITAM was essential for overall calcium response upon weak FcepsilonRI stimulation (at low antigen concentration), while upon strong stimulation (at high antigen concentration) it appeared necessary selectively to an immediate calcium response that was sensitive to the dihydropyridine receptor (DHPR) antagonist nifedipine and wortmannin but not to the store-operated calcium entry (SOCE) antagonists such as 2-aminoethoxyphenyl borate and SK&F96365.	amicloral	460-466	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	289-313
17845018-4	2007	These large inhibitors are not predicted to bind in that they protrude through the accessible surface calculated from a PNMT/7-aminosulfonyl-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) crystal structure, yet they are potent inhibitors of PNMT.	amicloral	173-179	phenylethanolamine N-methyltransferase	Homo sapiens	242-246
16279783-1	2005	The X-ray structure of human phenylethanolamine N-methyltransferase (hPNMT) complexed with its product, S-adenosyl-L-homocysteine (4), and the most potent inhibitor reported to date, SK&F 64139 (7), was used to identify the residues involved in inhibitor binding.	amicloral	183-189	phenylethanolamine N-methyltransferase	Homo sapiens	29-67
16838106-4	2007	TRPC7-transfected HEK293 cells showed an augmentation of carbachol-induced intracellular Ca2+ transient, which was attenuated under a Ca2+-free condition or in the presence of SK&F96365 (a Ca2+-permeable channel blocker).	amicloral	176-182	transient receptor potential cation channel subfamily C member 7	Homo sapiens	0-5
16838106-4	2007	TRPC7-transfected HEK293 cells showed an augmentation of carbachol-induced intracellular Ca2+ transient, which was attenuated under a Ca2+-free condition or in the presence of SK&F96365 (a Ca2+-permeable channel blocker).	amicloral	176-182	carbonic anhydrase 2	Homo sapiens	89-92
16838106-6	2007	Ang II-induced apoptosis was inhibited by CV-11974 (Candesartan; Ang II type 1 [AT1] receptor blocker), SK&F96365, and FK506 (calcineurin inhibitor).	amicloral	104-110	angiotensinogen	Rattus norvegicus	0-6
16778360-6	2006	IL-6 mRNA induction by CA-G alpha13 was suppressed by SK&F96365 (1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole hydrochloride), an inhibitor of receptor-activated nonselective cation channels, and the expression of CA-G alpha13 increased basal Ca2+ influx.	amicloral	54-60	interleukin 6	Rattus norvegicus	0-4
16778360-6	2006	IL-6 mRNA induction by CA-G alpha13 was suppressed by SK&F96365 (1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole hydrochloride), an inhibitor of receptor-activated nonselective cation channels, and the expression of CA-G alpha13 increased basal Ca2+ influx.	amicloral	54-60	G protein subunit alpha 13	Rattus norvegicus	26-35
16778360-6	2006	IL-6 mRNA induction by CA-G alpha13 was suppressed by SK&F96365 (1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole hydrochloride), an inhibitor of receptor-activated nonselective cation channels, and the expression of CA-G alpha13 increased basal Ca2+ influx.	amicloral	54-60	G protein subunit alpha 13	Rattus norvegicus	245-254
16519936-4	2006	Approximately 25% of the measured CaMKII autophosphorylation in DRG neurons in culture can be regulated by Ca(2+) flux from intracellular stores caused by manipulating [Ca(2+)](O), as shown by blocking refilling of store-operated Ca(2+)-channels with SK&F 96365, Ruthenium Red, and a partial block with Ni(2+).	amicloral	251-257	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	34-40
16622014-6	2006	Furthermore, the expression of p12(I) in Jurkat T cells using lentiviral vectors enhanced LFA-1-mediated cell adhesion, which was inhibited by the calcium chelator BAPTA-AM, the calcium channel blocker SK&F 96365, and calpeptin, an inhibitor of the calcium-dependent protease calpain.	amicloral	202-208	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	31-34
16622014-6	2006	Furthermore, the expression of p12(I) in Jurkat T cells using lentiviral vectors enhanced LFA-1-mediated cell adhesion, which was inhibited by the calcium chelator BAPTA-AM, the calcium channel blocker SK&F 96365, and calpeptin, an inhibitor of the calcium-dependent protease calpain.	amicloral	202-208	integrin subunit alpha L	Homo sapiens	90-95
16539844-4	2006	A combination of DIDS (1 micromol/L) and SK&F96365 (1 micromol/L) significantly diminished ConA-induced ClC-3 mRNA expression by 64%, whereas DIDS(1 micromol/L) or SK&F96365 (1 micromol/L) alone decreased ConA-induced ClC-3 mRNA expression by only 16% and 9%, respectively.	amicloral	41-47	chloride voltage-gated channel 3	Homo sapiens	108-113
16539844-4	2006	A combination of DIDS (1 micromol/L) and SK&F96365 (1 micromol/L) significantly diminished ConA-induced ClC-3 mRNA expression by 64%, whereas DIDS(1 micromol/L) or SK&F96365 (1 micromol/L) alone decreased ConA-induced ClC-3 mRNA expression by only 16% and 9%, respectively.	amicloral	41-47	chloride voltage-gated channel 3	Homo sapiens	226-231
16279783-1	2005	The X-ray structure of human phenylethanolamine N-methyltransferase (hPNMT) complexed with its product, S-adenosyl-L-homocysteine (4), and the most potent inhibitor reported to date, SK&F 64139 (7), was used to identify the residues involved in inhibitor binding.	amicloral	183-189	phenylethanolamine N-methyltransferase	Homo sapiens	69-74
15953564-6	2005	The stimulation by bupleuran 2IIc/PG-1 of cyclin D2 expression was significantly decreased by inhibitors, PI 3-kinase (LY294002 and Wortmannin), PLCgamma (U73122), PKC (H-7), receptor-operated calcium entry inhibitor (SK&F 96365), and calcineurin (FK506).	amicloral	218-224	cyclin D2	Mus musculus	42-51
15936930-5	2005	Pretreatment of the cells with calcium inhibitor SK&F96365 inhibited the LXA4-induced apoptosis, levels of [Ca2+]i, expression of calpain 10 and Smac.	amicloral	49-55	calpain 10	Rattus norvegicus	134-144
15936930-5	2005	Pretreatment of the cells with calcium inhibitor SK&F96365 inhibited the LXA4-induced apoptosis, levels of [Ca2+]i, expression of calpain 10 and Smac.	amicloral	49-55	diablo, IAP-binding mitochondrial protein	Rattus norvegicus	149-153
15358810-10	2004	Pharmacological studies using the imidazole derivatives SK&F96365 (30 microM) and LOE 908 (10 microM) partially inhibited the ET1-evoked Ca2+ response, thus providing evidence for the presence of both store-operated Ca2+ channels and non-selective cationic channels in the human ST.	amicloral	56-62	endothelin 1	Homo sapiens	130-133
15946532-5	2005	As compared with the control group, DIDS, SK&F96365 and Nifedipine could significantly reduce the PAG, Ca2+ release and Ca2+ influx in thrombin activated platelet (P < 0.05).	amicloral	42-48	coagulation factor II, thrombin	Homo sapiens	139-147
15946532-8	2005	The combination of NFA and SK&F96365 weakened each other"s effect on Ca2+ release (P < 0.05), while NFA and nifedipine weakened each other"s effects on PAG, Ca2+ release and Ca2+ influx in thrombin activated platelet (P < 0.05).	amicloral	27-33	coagulation factor II, thrombin	Homo sapiens	196-204
15358810-10	2004	Pharmacological studies using the imidazole derivatives SK&F96365 (30 microM) and LOE 908 (10 microM) partially inhibited the ET1-evoked Ca2+ response, thus providing evidence for the presence of both store-operated Ca2+ channels and non-selective cationic channels in the human ST.	amicloral	56-62	carbonic anhydrase 2	Homo sapiens	141-144
12847111-7	2003	Moreover, LPA-induced increases in Ca2+ transients and/or iNOS expression in highly purified rat liver nuclei were prevented by pertussis toxin, phosphoinositide 3-kinase/Akt inhibitor wortmannin and Ca2+ chelator and channel blockers EGTA and SK&F96365, respectively.	amicloral	244-250	nitric oxide synthase 2	Rattus norvegicus	58-62
12922939-8	2003	Both SK&F 96365 and LOE 908 inhibited ET-1-induced arachidonic acid release with the IC(50) values correlated to those of ET-1-induced Ca(2+) influx.	amicloral	5-11	endothelin 1	Homo sapiens	42-46
12920205-5	2003	Both SK&F 96365 and LOE 908 inhibited ET-1-induced AA release with the IC50 values correlated to those of ET-1-induced Ca2+ influx.	amicloral	5-11	endothelin-1	Cricetulus griseus	42-46
12920205-5	2003	Both SK&F 96365 and LOE 908 inhibited ET-1-induced AA release with the IC50 values correlated to those of ET-1-induced Ca2+ influx.	amicloral	5-11	endothelin-1	Cricetulus griseus	110-114
12922939-8	2003	Both SK&F 96365 and LOE 908 inhibited ET-1-induced arachidonic acid release with the IC(50) values correlated to those of ET-1-induced Ca(2+) influx.	amicloral	5-11	endothelin 1	Homo sapiens	126-130
12496270-9	2003	5) The constitutive expression of TGF-beta1 as well as up-regulation of the PA system observed in HRA cells was inhibited by preinoculation of the cells with bikunin or calcium channel blocker SK&F 96365 but not with nifedipine or verapamil, with an IC(50) of approximately 100 nm for bikunin or approximately 30 microm for SK&F 96365, respectively, as measured by enzyme-linked immunosorbent assay.	amicloral	193-199	transforming growth factor beta 1	Homo sapiens	34-43
12496270-9	2003	5) The constitutive expression of TGF-beta1 as well as up-regulation of the PA system observed in HRA cells was inhibited by preinoculation of the cells with bikunin or calcium channel blocker SK&F 96365 but not with nifedipine or verapamil, with an IC(50) of approximately 100 nm for bikunin or approximately 30 microm for SK&F 96365, respectively, as measured by enzyme-linked immunosorbent assay.	amicloral	193-199	alpha-1-microglobulin/bikunin precursor	Homo sapiens	289-296
12496270-9	2003	5) The constitutive expression of TGF-beta1 as well as up-regulation of the PA system observed in HRA cells was inhibited by preinoculation of the cells with bikunin or calcium channel blocker SK&F 96365 but not with nifedipine or verapamil, with an IC(50) of approximately 100 nm for bikunin or approximately 30 microm for SK&F 96365, respectively, as measured by enzyme-linked immunosorbent assay.	amicloral	328-334	transforming growth factor beta 1	Homo sapiens	34-43
12496270-9	2003	5) The constitutive expression of TGF-beta1 as well as up-regulation of the PA system observed in HRA cells was inhibited by preinoculation of the cells with bikunin or calcium channel blocker SK&F 96365 but not with nifedipine or verapamil, with an IC(50) of approximately 100 nm for bikunin or approximately 30 microm for SK&F 96365, respectively, as measured by enzyme-linked immunosorbent assay.	amicloral	328-334	alpha-1-microglobulin/bikunin precursor	Homo sapiens	158-165
12529253-7	2003	The Ca(2+) channels activated by ET-1 in wortmannin- or LY-294002-treated CHO-ET(B)R were sensitive to LOE 908 and resistant to SK&F 96365.	amicloral	128-134	endothelin-1	Cricetulus griseus	33-37
12568361-6	2003	SK&F96365 blocked vasopressin-induced Ca2+ influx in a dose-dependent manner.	amicloral	0-6	arginine vasopressin	Rattus norvegicus	22-33
11827704-8	2002	Furthermore, p38 MAPK inhibitors SB203580 or SK&F86002 markedly reduced oxLDL-induced CXCR2 expression.	amicloral	45-51	mitogen-activated protein kinase 14	Homo sapiens	13-16
12427604-1	2002	The purpose of this study was to demonstrate the involvement of Ca(2+) influx through voltage-independent Ca(2+) channels (VICCs) in endothelin-1 (ET-1)-induced transactivation of epidermal growth factor receptor protein tyrosine kinase (EGFR PTK) using the Ca(2+) channel blockers LOE-908 and SK&F-96365 in rabbit internal carotid artery vascular smooth muscle cells.	amicloral	294-300	endothelin-1	Oryctolagus cuniculus	133-145
12427604-1	2002	The purpose of this study was to demonstrate the involvement of Ca(2+) influx through voltage-independent Ca(2+) channels (VICCs) in endothelin-1 (ET-1)-induced transactivation of epidermal growth factor receptor protein tyrosine kinase (EGFR PTK) using the Ca(2+) channel blockers LOE-908 and SK&F-96365 in rabbit internal carotid artery vascular smooth muscle cells.	amicloral	294-300	endothelin-1	Oryctolagus cuniculus	147-151
12427604-1	2002	The purpose of this study was to demonstrate the involvement of Ca(2+) influx through voltage-independent Ca(2+) channels (VICCs) in endothelin-1 (ET-1)-induced transactivation of epidermal growth factor receptor protein tyrosine kinase (EGFR PTK) using the Ca(2+) channel blockers LOE-908 and SK&F-96365 in rabbit internal carotid artery vascular smooth muscle cells.	amicloral	294-300	epidermal growth factor receptor	Oryctolagus cuniculus	180-212
12198330-7	2002	Both LOE 908 and SK&F 96365 inhibit endothelin-1-induced contraction in a concentration-dependent manner, and their combination abolished it.	amicloral	17-23	endothelin-1	Oryctolagus cuniculus	40-52
12183654-8	2002	SK&F 96365 and econazole but not GdCl(3) inhibited PACAP-induced CA release.	amicloral	0-6	adenylate cyclase activating polypeptide 1	Bos taurus	55-60
12131556-1	2002	Endothelin-1 (ET-1) has been shown to activate three types of Ca2+ channel, namely two Ca2+-permeable nonselective cation channels (designated NSCC-1 and NSCC-2) and a store-operated Ca2+ channel (SOCC), and that these channels can be discriminated by Ca2+ channel blockers such as LOE 908 (a blocker of NSCC-1 and NSCC-2) and SK&F 96365 (a blocker of NSCC-2 and SOCC).	amicloral	327-333	endothelin 1	Rattus norvegicus	0-12
12131556-1	2002	Endothelin-1 (ET-1) has been shown to activate three types of Ca2+ channel, namely two Ca2+-permeable nonselective cation channels (designated NSCC-1 and NSCC-2) and a store-operated Ca2+ channel (SOCC), and that these channels can be discriminated by Ca2+ channel blockers such as LOE 908 (a blocker of NSCC-1 and NSCC-2) and SK&F 96365 (a blocker of NSCC-2 and SOCC).	amicloral	327-333	endothelin 1	Rattus norvegicus	14-18
12088864-10	2002	Both SK&F 96365, a receptor-operated Ca(2+) channel (ROC) blocker and nimodipine, an L-type Ca(2+) channel blocker, reduced BK-induced [Ca(2+)](i) increase and glucagon release.	amicloral	5-11	kininogen 1	Homo sapiens	128-130
12069846-5	2002	The thapsigargin-induced activation of NF-kappaB was inhibited by the PAF synthesis inhibitor SK&F 98625 and the PAF antagonist E6123.	amicloral	94-100	PCNA clamp associated factor	Rattus norvegicus	70-73
12005183-3	2002	Both nifedipine and SK&F96365 inhibited 10 nM ET-1-induced [3H]-thymidine incorporation into VSMC with the maximal inhibitory concentrations of 1 and 10 microM, respectively.	amicloral	20-26	endothelin 1	Rattus norvegicus	50-54
12005183-6	2002	Pretreatment of VSMC with 1 microM nifedipine completely inhibited the DIDS effect on 10 nM ET-1-induced [3H]-thymidine incorporation into VSMC and sustained increase in [Ca2+]i, whereas pretreatment with 10 microM SK&F96365 did not completely block these effects of DIDS.	amicloral	215-221	endothelin 1	Rattus norvegicus	92-96
11827704-8	2002	Furthermore, p38 MAPK inhibitors SB203580 or SK&F86002 markedly reduced oxLDL-induced CXCR2 expression.	amicloral	45-51	C-X-C motif chemokine receptor 2	Homo sapiens	90-95
11600432-2	2001	In both CHO-ET(A) and CHO-ET(B), ET-1 at 0.1 nM activated the Ca(2+)-permeable nonselective cation channel-1 (NSCC-1), which was sensitive to LOE-908 and resistant to SK&F-96365.	amicloral	167-173	endothelin-1	Cricetulus griseus	33-37
11779582-6	2002	The SK&F 98625-induced suppression of interleukin-6 mRNA accumulation and interleukin-6 production was partially restored by addition of exogenous prostaglandin E2.	amicloral	4-10	interleukin 6	Rattus norvegicus	42-55
11779582-6	2002	The SK&F 98625-induced suppression of interleukin-6 mRNA accumulation and interleukin-6 production was partially restored by addition of exogenous prostaglandin E2.	amicloral	4-10	interleukin 6	Rattus norvegicus	78-91
11786495-16	2002	The ET-1-induced hyperpolarisation was insensitive to nifedipine but was attenuated by SK&F 96365 (1 - [beta-[3-(4 - methoxy - phenyl)propoxy] - 4 - methoxyphenethyl] - 1H-imidazole hydrochloride, 50 microM), an inhibitor of receptor-mediated Ca(2+) entry.	amicloral	87-93	endothelin-1	Cavia porcellus	4-8
11600432-4	2001	ET-1 at 10 nM activated the same channels as 1 nM ET-1 in both cell types, but in CHO-ET(A), it additionally activated the store-operated Ca(2+) channel (SOCC), which was resistant to LOE-908 and sensitive to SK&F-96365.	amicloral	209-215	endothelin-1	Cricetulus griseus	0-4
11494311-5	2001	SK&F 96365 inhibited capacitative Ca2+ entry in a dose-dependent manner (I50: 1-5 microM).	amicloral	0-6	carbonic anhydrase 2	Mus musculus	38-41
11494311-11	2001	These results indicate that the inhibitory effects of SK&F 96365 and DBHQ on cell proliferation were due to the inhibition of capacitative Ca2+ entry and Ca2+ mobilization suggesting the importance of capacitative Ca2+ entry and Ca2+ mobilization in the control of EGF-induced cell cycle progression in mouse mammary epithelial cells.	amicloral	54-60	carbonic anhydrase 2	Mus musculus	143-146
11494311-11	2001	These results indicate that the inhibitory effects of SK&F 96365 and DBHQ on cell proliferation were due to the inhibition of capacitative Ca2+ entry and Ca2+ mobilization suggesting the importance of capacitative Ca2+ entry and Ca2+ mobilization in the control of EGF-induced cell cycle progression in mouse mammary epithelial cells.	amicloral	54-60	carbonic anhydrase 2	Mus musculus	158-161
11494311-11	2001	These results indicate that the inhibitory effects of SK&F 96365 and DBHQ on cell proliferation were due to the inhibition of capacitative Ca2+ entry and Ca2+ mobilization suggesting the importance of capacitative Ca2+ entry and Ca2+ mobilization in the control of EGF-induced cell cycle progression in mouse mammary epithelial cells.	amicloral	54-60	carbonic anhydrase 2	Mus musculus	158-161
11494311-11	2001	These results indicate that the inhibitory effects of SK&F 96365 and DBHQ on cell proliferation were due to the inhibition of capacitative Ca2+ entry and Ca2+ mobilization suggesting the importance of capacitative Ca2+ entry and Ca2+ mobilization in the control of EGF-induced cell cycle progression in mouse mammary epithelial cells.	amicloral	54-60	carbonic anhydrase 2	Mus musculus	158-161
11494311-11	2001	These results indicate that the inhibitory effects of SK&F 96365 and DBHQ on cell proliferation were due to the inhibition of capacitative Ca2+ entry and Ca2+ mobilization suggesting the importance of capacitative Ca2+ entry and Ca2+ mobilization in the control of EGF-induced cell cycle progression in mouse mammary epithelial cells.	amicloral	54-60	epidermal growth factor	Mus musculus	269-272
11522324-1	2001	Ca(2+) channels activated by endothelin-1 (ET-1) in C6 glioma cells (C6 cells) were characterized using whole-cell patch-clamps and by monitoring the intracellular free Ca(2+) concentration ([Ca(2+)](i)), when administering Ca(2+) channel blockers such as LOE 908 and SK&F 96365.	amicloral	268-274	endothelin 1	Homo sapiens	29-41
11522324-1	2001	Ca(2+) channels activated by endothelin-1 (ET-1) in C6 glioma cells (C6 cells) were characterized using whole-cell patch-clamps and by monitoring the intracellular free Ca(2+) concentration ([Ca(2+)](i)), when administering Ca(2+) channel blockers such as LOE 908 and SK&F 96365.	amicloral	268-274	endothelin 1	Homo sapiens	43-47
11065174-3	2000	Removal of extracellular Ca2+ as well as SK&F96365 reduced the contraction due to the PAR-1 agonist TFLLR-NH2 (TFp-NH2) by 60-80% that was similar to the extent of the inhibition by nifedipine.	amicloral	41-47	coagulation factor II (thrombin) receptor	Rattus norvegicus	90-95
11444496-2	2001	In cultured porcine aortic endothelial cells, the sustained increases in the intracellular Ca2+ concentration ([Ca2+]i) elicited by bradykinin and cyclopiazonic acid, which were strongly dependent on the presence of extracellular Ca2+, were suppressed by the NSCC blockers, SK&F 96365 and mefenamic acid.	amicloral	274-280	kininogen 1	Homo sapiens	132-142
11444496-4	2001	In the presence of SK&F 96365 or mefenamic acid, the peak amplitude was severely reduced and the decay phase of hyperpolarization to bradykinin was greatly accelerated, which was apparently similar to the response obtained in Ca2+-free medium.	amicloral	19-25	kininogen 1	Homo sapiens	137-147
11282120-6	2001	The contractile response to vasopressin was partly inhibited by nifedipine, SK&F 96365 (1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole) and niflumic acid.	amicloral	76-82	arginine vasopressin	Rattus norvegicus	28-39
11082111-13	2000	Ang II-induced contraction was insensitive to inhibition by nifedipine (0.1 microM), an antagonist of L-type voltage-gated Ca(2+) channels, and SK&F96365 (10 microM), which blocks non-selective cation channels, whereas that to ET-1 was inhibited by SK&F69365.	amicloral	144-150	angiotensinogen	Rattus norvegicus	0-6
11082111-13	2000	Ang II-induced contraction was insensitive to inhibition by nifedipine (0.1 microM), an antagonist of L-type voltage-gated Ca(2+) channels, and SK&F96365 (10 microM), which blocks non-selective cation channels, whereas that to ET-1 was inhibited by SK&F69365.	amicloral	253-259	angiotensinogen	Rattus norvegicus	0-6
11034409-11	2000	Both capsaicin and SK&F96365 also inhibited PAF-induced cytosolic superoxide generation in HL-60 cells differentiated by all-trans-retinoic acid.	amicloral	19-25	PCNA clamp associated factor	Homo sapiens	48-51
10496327-8	1999	The responses to lower concentrations of ET-1 (< or = 0.1 nM) were abolished by either SK&F 96365 or LOE 908 alone.	amicloral	90-96	endothelin 1	Rattus norvegicus	41-45
11078350-4	2000	Our results show that the response to lower concentrations of ET-1 involves only one Ca2+ channel which is sensitive to SK&F 96365 and LOE 908 (NSCC-2).	amicloral	120-126	endothelin 1	Rattus norvegicus	62-66
11078350-5	2000	In contrast, the response to higher concentrations of ET-1 involves two types of Ca2+ channel in addition to NSCC-2: one is sensitive to SK&F 96365 but resistant to LOE 908 (SOCC), and the other is resistant to SK&F 96365 but sensitive to LOE 908 (NSCC-1).	amicloral	137-143	endothelin 1	Rattus norvegicus	54-58
11078350-5	2000	In contrast, the response to higher concentrations of ET-1 involves two types of Ca2+ channel in addition to NSCC-2: one is sensitive to SK&F 96365 but resistant to LOE 908 (SOCC), and the other is resistant to SK&F 96365 but sensitive to LOE 908 (NSCC-1).	amicloral	215-221	endothelin 1	Rattus norvegicus	54-58
11078351-7	2000	In contrast, the increase caused by higher concentrations of ET-1 (> or = 1 nM) was suppressed by SK&F 96365 or LOE 908 to about 35% of controls, and abolished by combined treatment with SK&F 96365 and LOE 908.	amicloral	101-107	endothelin 1	Rattus norvegicus	61-65
11078351-7	2000	In contrast, the increase caused by higher concentrations of ET-1 (> or = 1 nM) was suppressed by SK&F 96365 or LOE 908 to about 35% of controls, and abolished by combined treatment with SK&F 96365 and LOE 908.	amicloral	194-200	endothelin 1	Rattus norvegicus	61-65
10619177-6	1999	These results indicate that ET-1 augments the release of catecholamines from adrenal chromaffin cells through ET(A) receptors, by activating two types of Ca2+ entry channels in addition to L-type VOCC: one (nonselective cation channel-1; NSCC-1) is sensitive to LOE 908 but resistant to SK&F 96365, whereas the other (NSCC-2) is sensitive to both LOE 908 and SK&F 96365.	amicloral	287-293	endothelin 1	Bos taurus	28-32
10619177-6	1999	These results indicate that ET-1 augments the release of catecholamines from adrenal chromaffin cells through ET(A) receptors, by activating two types of Ca2+ entry channels in addition to L-type VOCC: one (nonselective cation channel-1; NSCC-1) is sensitive to LOE 908 but resistant to SK&F 96365, whereas the other (NSCC-2) is sensitive to both LOE 908 and SK&F 96365.	amicloral	363-369	endothelin 1	Bos taurus	28-32
10629863-8	1999	In contrast, the increase in [Ca2+]i induced by higher concentrations of ET-1 was partially suppressed to approximately 30% of controls by either SK&F 96365 or LOE 908 alone, and it was abolished by their combination.	amicloral	146-152	endothelin 1	Rattus norvegicus	73-77
10629864-6	1999	The responses to lower concentrations (< or = 0.1 nM) of ET-1 were abolished by either SK&F 96365 or LOE 908.	amicloral	90-96	endothelin 1	Rattus norvegicus	60-64
10629864-8	1999	4) These results show that the contractions and increases in [Ca2+]i of rat aortic smooth muscles at lower concentrations of ET-1 involve only one Ca2+ entry channel which is sensitive to SK&F 96365 and LOE 908 (NSCC-2), whereas those at higher concentrations of ET-1 involve another Ca2+ entry channel which is sensitive to SK&F 96365 but resistant to LOE 908 (SOCC) in addition to the former channel.	amicloral	188-194	endothelin 1	Rattus norvegicus	125-129
10629864-8	1999	4) These results show that the contractions and increases in [Ca2+]i of rat aortic smooth muscles at lower concentrations of ET-1 involve only one Ca2+ entry channel which is sensitive to SK&F 96365 and LOE 908 (NSCC-2), whereas those at higher concentrations of ET-1 involve another Ca2+ entry channel which is sensitive to SK&F 96365 but resistant to LOE 908 (SOCC) in addition to the former channel.	amicloral	188-194	endothelin 1	Rattus norvegicus	267-271
10629864-8	1999	4) These results show that the contractions and increases in [Ca2+]i of rat aortic smooth muscles at lower concentrations of ET-1 involve only one Ca2+ entry channel which is sensitive to SK&F 96365 and LOE 908 (NSCC-2), whereas those at higher concentrations of ET-1 involve another Ca2+ entry channel which is sensitive to SK&F 96365 but resistant to LOE 908 (SOCC) in addition to the former channel.	amicloral	329-335	endothelin 1	Rattus norvegicus	125-129
10496327-9	1999	In contrast, the responses to higher concentrations of ET-1 (> or = 1 nM) were suppressed by SK&F 96365 or LOE 908 to about 10% and 35% of controls, respectively, and abolished by combined treatment with SK&F 96365 and LOE 908.	amicloral	96-102	endothelin 1	Rattus norvegicus	55-59
10496327-9	1999	In contrast, the responses to higher concentrations of ET-1 (> or = 1 nM) were suppressed by SK&F 96365 or LOE 908 to about 10% and 35% of controls, respectively, and abolished by combined treatment with SK&F 96365 and LOE 908.	amicloral	211-217	endothelin 1	Rattus norvegicus	55-59
10496327-10	1999	These results show that the responses of rat aorta to lower concentrations of ET-1 involve only one Ca2+ channel that is sensitive to SK&F 96365 and LOE 908 (NSCC-2), whereas those to higher concentrations of ET-1 involve NSCC-1, NSCC-2 and SOCC, contributing 10%, 55% and 35%, respectively, to total Ca2+ entry.	amicloral	134-140	endothelin 1	Rattus norvegicus	78-82
10448892-4	1999	SNP (10 microM), NOC-9 (10 microM) and BNP (1 microM) all increased intracellular cyclic GMP to similar levels (2- to 2.5-fold above basal) and caused significant enhancement of CGRP (10 nM)-induced cyclic AMP accumulation similar to that caused by 10 microM SK&F 94120.	amicloral	259-265	natriuretic peptide B	Rattus norvegicus	39-42
10448892-4	1999	SNP (10 microM), NOC-9 (10 microM) and BNP (1 microM) all increased intracellular cyclic GMP to similar levels (2- to 2.5-fold above basal) and caused significant enhancement of CGRP (10 nM)-induced cyclic AMP accumulation similar to that caused by 10 microM SK&F 94120.	amicloral	259-265	calcitonin-related polypeptide alpha	Rattus norvegicus	178-182
10455288-6	1999	The responses to lower concentrations (< or =0.1 nM) of ET-1 were abolished by either SK&F 96365 or LOE 908.	amicloral	89-95	endothelin 1	Rattus norvegicus	59-63
10443571-4	1999	(2) Endothelin-1-induced vasoconstriction is mediated by Ca2+ influx through a non-selective cation channel sensitive to 1-[beta-[3-(4-methoxyphenyl) propoxyl]-4-methoxyphenethyl]-1H-imidazole HCl (SK & F96365).	amicloral	198-205	endothelin 1	Homo sapiens	4-16
10354406-7	1999	Remarkably, 7-aminosulfonyl-3-hydroxymethyl-THIQ (12; PNMT Ki = 0.34 microM, alpha2 Ki = 1400 microM, selectivity = 4100) displayed a 23-680-fold enhanced selectivity over the parent compounds 27 (SK&F 29661; PNMT Ki = 0.55 microM, alpha2 Ki = 100 microM, selectivity = 180) and 4 (selectivity = 6.0) and is thus the most selective PNMT inhibitor yet reported.	amicloral	197-203	phenylethanolamine N-methyltransferase	Homo sapiens	54-58
10354406-7	1999	Remarkably, 7-aminosulfonyl-3-hydroxymethyl-THIQ (12; PNMT Ki = 0.34 microM, alpha2 Ki = 1400 microM, selectivity = 4100) displayed a 23-680-fold enhanced selectivity over the parent compounds 27 (SK&F 29661; PNMT Ki = 0.55 microM, alpha2 Ki = 100 microM, selectivity = 180) and 4 (selectivity = 6.0) and is thus the most selective PNMT inhibitor yet reported.	amicloral	197-203	phenylethanolamine N-methyltransferase	Homo sapiens	213-217
10354406-7	1999	Remarkably, 7-aminosulfonyl-3-hydroxymethyl-THIQ (12; PNMT Ki = 0.34 microM, alpha2 Ki = 1400 microM, selectivity = 4100) displayed a 23-680-fold enhanced selectivity over the parent compounds 27 (SK&F 29661; PNMT Ki = 0.55 microM, alpha2 Ki = 100 microM, selectivity = 180) and 4 (selectivity = 6.0) and is thus the most selective PNMT inhibitor yet reported.	amicloral	197-203	phenylethanolamine N-methyltransferase	Homo sapiens	213-217
10455288-8	1999	SK&F 96365 inhibited the LOE 908-resistant contractions induced by higher concentrations of ET-1 with IC50 values similar to those for contractions induced by thapsigargin or ionomycin.	amicloral	0-6	endothelin 1	Rattus norvegicus	96-100
10455288-9	1999	These results show that the contractions and increases in [Ca2+]i of rat aortic smooth muscles at lower concentrations of ET-1 involve only one Ca2+ entry channel which is sensitive to SK&F 96365 and LOE 908 (NSCC-2), whereas those at higher concentrations of ET-1 involve another Ca2+ entry channel which is sensitive to SK&F 96365 but resistant to LOE 908 (SOCC) in addition to the former channel.	amicloral	185-191	endothelin 1	Rattus norvegicus	122-126
10455288-9	1999	These results show that the contractions and increases in [Ca2+]i of rat aortic smooth muscles at lower concentrations of ET-1 involve only one Ca2+ entry channel which is sensitive to SK&F 96365 and LOE 908 (NSCC-2), whereas those at higher concentrations of ET-1 involve another Ca2+ entry channel which is sensitive to SK&F 96365 but resistant to LOE 908 (SOCC) in addition to the former channel.	amicloral	185-191	endothelin 1	Rattus norvegicus	264-268
10463102-7	1999	SK&F 96365 had a stimulatory effect on PAF-induced [Ca2+]i rise and on fMLP-induced O2- production, this phenomenon was not observed with extracellular Ca2+ removal or chelation.	amicloral	0-6	PCNA clamp associated factor	Homo sapiens	43-46
10463102-7	1999	SK&F 96365 had a stimulatory effect on PAF-induced [Ca2+]i rise and on fMLP-induced O2- production, this phenomenon was not observed with extracellular Ca2+ removal or chelation.	amicloral	0-6	formyl peptide receptor 1	Homo sapiens	75-79
10204997-13	1999	The sustained increases by lower and higher [ET-1] were abolished by removal of extracellular Ca2+, and they were suppressed by LOE 908 to 0 and 35%, respectively, with the LOE 908-resistant part being abolished by SK&F 96365.	amicloral	215-221	endothelin 1	Rattus norvegicus	45-49
9873525-1	1998	A series of amidine substituted phenyl-, benzyl-, and phenethylimidazoles based on the known H3 agonist SK&F 91606 (4) has been synthesized and tested as ligands for the histamine H3 receptor.	amicloral	104-110	histamine receptor H3	Homo sapiens	174-195
9795163-10	1998	SK&F 96365 inhibited VIP-induced secretion completely and rises in [Ca2+]i by 75%.	amicloral	0-6	vasoactive intestinal peptide	Rattus norvegicus	25-28
9776313-1	1998	SK&F 96365 (1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenylethyl]-1H-imi dazole hydrochloride) stimulated the accumulation of [3H]inositol monophosphates ([3H]IP1) in human U373 MG astrocytoma cells prelabelled with [3H]inositol (EC50 15 +/- 1 microM, Hill coefficient 3.8 +/- 0.4).	amicloral	0-6	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	168-171
9776313-2	1998	SK&F 96365-induced accumulation of [3H]IP1 increased linearly with time, but there was no initial rapid formation of [3H]IP3.	amicloral	0-6	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	43-46
9776313-4	1998	SK&F 96365-induced accumulation of [3H]IP1 in U373 MG cells increased as extracellular Ca2+ was increased from nominally zero to 4 mM, but there was no evidence that SK&F 96365 induced any marked entry of Ca2+ into cells; only an inhibition of store-refilling-induced Ca2+ entry was apparent.	amicloral	0-6	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	43-46
9809851-9	1998	The significant increases in sniffing, grooming and intense grooming and the significant decrease in stillness induced by the DA D1 agonist, SK&F 38393 [(+/-)-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrochloride], were not altered by concomitant pre-treatment with NDL-249.	amicloral	141-147	defender against cell death 1	Rattus norvegicus	126-131
9834082-2	1998	Here, we report that inhibitors of the p38 mitogen-activated kinase (p38 MAPK), SK&F 86002 or the more selective inhibitor, SB 203580, reduce the levels of soluble CD23 formed by IL-4-stimulated human monocytes or the human monocytic cell line, U937.	amicloral	80-86	mitogen-activated protein kinase 14	Homo sapiens	39-42
9834082-2	1998	Here, we report that inhibitors of the p38 mitogen-activated kinase (p38 MAPK), SK&F 86002 or the more selective inhibitor, SB 203580, reduce the levels of soluble CD23 formed by IL-4-stimulated human monocytes or the human monocytic cell line, U937.	amicloral	80-86	Fc epsilon receptor II	Homo sapiens	168-172
9834082-2	1998	Here, we report that inhibitors of the p38 mitogen-activated kinase (p38 MAPK), SK&F 86002 or the more selective inhibitor, SB 203580, reduce the levels of soluble CD23 formed by IL-4-stimulated human monocytes or the human monocytic cell line, U937.	amicloral	80-86	interleukin 4	Homo sapiens	183-187
9834082-4	1998	Further, evaluation of surface intact CD23 (iCD23) by flow cytometry demonstrated that SK&F 86002 and SB 203580 reduced the surface expression of iCD23 in a concentration-dependent fashion, while batimastat increased the surface expression of iCD23.	amicloral	87-93	Fc epsilon receptor II	Homo sapiens	38-42
9723969-14	1998	The current at lower [ET-1] was resistant to SK&F 96365 but was abolished by replacement of Ca2+ in the bath solution with Mn2+.	amicloral	45-51	endothelin 1	Rattus norvegicus	22-26
9723969-15	1998	The current at higher [ET-1] was abolished by the replacement plus SK&F 96365.	amicloral	67-73	endothelin 1	Rattus norvegicus	23-27
9723969-17	1998	In a bath solution containing only Ca2+ as a movable cation, ET-1 evoked currents: the current at lower [ET-1] was sensitive to Mn2+, whereas that at higher [ET-1] was partly sensitive to SK&F 96365.	amicloral	188-194	endothelin 1	Rattus norvegicus	61-65
9600332-0	1998	Inhibition of tumor necrosis factor-alpha production by SK&F 98625, a CoA-independent transacylase inhibitor, in cultured rat peritoneal macrophages.	amicloral	56-62	tumor necrosis factor	Rattus norvegicus	14-41
9716353-13	1998	Finally, increasing doses of alnespirone or 8-OH-DPAT weakly increased sniffing induced by apomorphine (0.75 mg/kg, s.c.) in mice and decreased grooming induced by the dopamine D1 receptor agonist SK&F 39393 ((+/-)-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol, 1.87 mg/kg, s.c.), whereas buspirone decreased both apomorphine-induced sniffing and SK&F 39393-induced grooming.	amicloral	197-203	dopamine receptor D1	Mus musculus	168-188
9716360-5	1998	HCl(SK&F 96365) suppressed the endothelin-1-induced contraction and increase in [Ca2+]i to the level similar to that after removal of extracellular Ca2+.	amicloral	4-10	endothelin 1	Homo sapiens	35-47
9600332-2	1998	In the presence of SK&F 98625, a CoA-independent transacylase inhibitor, the thapsigargin-induced TNF-alpha production was inhibited dose-dependently.	amicloral	19-25	tumor necrosis factor	Rattus norvegicus	102-111
9600332-3	1998	Platelet-activating factor (PAF) and prostaglandin E2 (PGE2) production were also inhibited by SK&F 98625.	amicloral	95-101	PCNA clamp associated factor	Rattus norvegicus	0-26
9600332-3	1998	Platelet-activating factor (PAF) and prostaglandin E2 (PGE2) production were also inhibited by SK&F 98625.	amicloral	95-101	PCNA clamp associated factor	Rattus norvegicus	28-31
9600332-4	1998	The SK&F 98625-induced inhibition of TNF-alpha production was not prevented by addition of PGE2.	amicloral	4-10	tumor necrosis factor	Rattus norvegicus	41-50
9600332-6	1998	The inhibition by SK&F 98625 of thapsigargin-induced TNF-alpha production might be partly due to the inhibition of PAF production.	amicloral	18-24	tumor necrosis factor	Rattus norvegicus	57-66
9600332-6	1998	The inhibition by SK&F 98625 of thapsigargin-induced TNF-alpha production might be partly due to the inhibition of PAF production.	amicloral	18-24	PCNA clamp associated factor	Rattus norvegicus	119-122
9698043-6	1998	It indicated that SK&F 108566 is a high affinity competitive antagonist at AT1 receptors in the proximal tubule.	amicloral	18-24	angiotensin II receptor, type 1a	Rattus norvegicus	79-82
9406590-0	1997	Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the alpha 2-adrenoceptor.	amicloral	125-131	phenylethanolamine N-methyltransferase	Homo sapiens	162-200
9406590-1	1997	7-(Aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661, 1) is a potent inhibitor of the enzyme phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28).	amicloral	50-56	phenylethanolamine N-methyltransferase	Homo sapiens	105-143
9406590-1	1997	7-(Aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661, 1) is a potent inhibitor of the enzyme phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28).	amicloral	50-56	phenylethanolamine N-methyltransferase	Homo sapiens	145-149
9406818-4	1997	Removal of extracellular Ca2+ or addition of Ca2+-entry blocker La3+ or SK&F 96365 inhibited Ca(i) oscillations, suggesting that Ca(i) oscillations in ras-transfected HaCaT keratinocytes were dependent on Ca2+ influx across the plasma membrane.	amicloral	72-78	carbonic anhydrase 1	Homo sapiens	97-102
9406818-4	1997	Removal of extracellular Ca2+ or addition of Ca2+-entry blocker La3+ or SK&F 96365 inhibited Ca(i) oscillations, suggesting that Ca(i) oscillations in ras-transfected HaCaT keratinocytes were dependent on Ca2+ influx across the plasma membrane.	amicloral	72-78	carbonic anhydrase 1	Homo sapiens	133-138
9309381-2	1997	IL6 is another cytokine important in the mechanisms of bone resorption and could be a target for the actions of SK&F 86002.	amicloral	112-118	interleukin 6	Homo sapiens	0-3
9259410-4	1997	PC-6/SN2-5 cells were resistant to SN-38 (32-fold) and SK&F 104864 (topotecan; 14-fold), but barely resistant to CPT-11 (3-fold) and DX-8951f (2-fold).	amicloral	55-61	proprotein convertase subtilisin/kexin type 5	Homo sapiens	0-4
9276129-11	1997	Pretreatment of cells with SK&F 96365 resulted in an inhibition of greater than 60% of the BK response.	amicloral	27-33	kininogen 1	Canis lupus familiaris	95-97
9144511-3	1997	Using freshly elutriated human monocytes, we examined the effect on PGHS-2 expression of certain cytokine-suppressive anti-inflammatory drugs such as SK&F 86002.	amicloral	150-156	prostaglandin-endoperoxide synthase 2	Homo sapiens	68-74
9144511-5	1997	SK&F 86002 dose-dependently inhibited this STZ-induced expression of PGHS-2 protein, which correlated with a decrease in prostaglandin E2 and thromboxane A2 production.	amicloral	0-6	prostaglandin-endoperoxide synthase 2	Homo sapiens	73-79
9144511-6	1997	However, suppression of PGHS-2 expression is not the result of suppressed cytokine production, because SK&F 86002 suppressed PGHS-2 expression initiated by IL-1beta and TNF-alpha, in addition to other stimuli.	amicloral	103-109	prostaglandin-endoperoxide synthase 2	Homo sapiens	24-30
9144511-6	1997	However, suppression of PGHS-2 expression is not the result of suppressed cytokine production, because SK&F 86002 suppressed PGHS-2 expression initiated by IL-1beta and TNF-alpha, in addition to other stimuli.	amicloral	103-109	prostaglandin-endoperoxide synthase 2	Homo sapiens	129-135
9144511-6	1997	However, suppression of PGHS-2 expression is not the result of suppressed cytokine production, because SK&F 86002 suppressed PGHS-2 expression initiated by IL-1beta and TNF-alpha, in addition to other stimuli.	amicloral	103-109	interleukin 1 beta	Homo sapiens	160-168
9144511-6	1997	However, suppression of PGHS-2 expression is not the result of suppressed cytokine production, because SK&F 86002 suppressed PGHS-2 expression initiated by IL-1beta and TNF-alpha, in addition to other stimuli.	amicloral	103-109	tumor necrosis factor	Homo sapiens	173-182
9144511-9	1997	These results indicate a new and potentially important anti-inflammatory property of SK&F 86002, namely the specific suppression of PGHS-2 induction.	amicloral	85-91	prostaglandin-endoperoxide synthase 2	Homo sapiens	136-142
9113376-17	1997	The ET-1-induced current was reversibly and completely inhibited by 30 microM SK&F 96365 or 500 microM Cd2+.	amicloral	78-84	endothelin 1	Rattus norvegicus	4-8
9150842-5	1997	Results from clinical studies using receptor antagonists, such as LY-171883, SK&F-104353, ICI-204219, ONO-1078, MK-751, MK-0679, demonstrate beneficial effects, with improvement in symptoms and forced expiratory volume in one second (FEV1), and a reduction in the use of beta 2-adrenergic relief medication.	amicloral	77-83	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	275-281
9335411-5	1997	Mefenamic acid and SK&F 96365 inhibited the ET-1-induced contraction with 50% inhibitory concentration (IC50) values of 10(-4) M and 2 x 10(-5) M, respectively, and abolished it at 10(-3) M and 10(-4) M. By contrast, nifedipine, mefenamic acid, or SK&F 96365 had little effect on the contraction by a high concentration of ET-1.	amicloral	19-25	endothelin-1	Oryctolagus cuniculus	48-52
9335411-5	1997	Mefenamic acid and SK&F 96365 inhibited the ET-1-induced contraction with 50% inhibitory concentration (IC50) values of 10(-4) M and 2 x 10(-5) M, respectively, and abolished it at 10(-3) M and 10(-4) M. By contrast, nifedipine, mefenamic acid, or SK&F 96365 had little effect on the contraction by a high concentration of ET-1.	amicloral	19-25	endothelin-1	Oryctolagus cuniculus	331-335
9335411-5	1997	Mefenamic acid and SK&F 96365 inhibited the ET-1-induced contraction with 50% inhibitory concentration (IC50) values of 10(-4) M and 2 x 10(-5) M, respectively, and abolished it at 10(-3) M and 10(-4) M. By contrast, nifedipine, mefenamic acid, or SK&F 96365 had little effect on the contraction by a high concentration of ET-1.	amicloral	252-258	endothelin-1	Oryctolagus cuniculus	48-52
9298542-11	1997	The relaxant effects induced by SK&F 94120 and rolipram were inhibited by Rp-8-Br-cyclic GMPS with no significant effect of H-89.	amicloral	32-38	guanine monophosphate synthase	Rattus norvegicus	93-97
9309381-4	1997	Both indomethacin (5 x 10(-8)-5 x 10(-6) M) and SK&F 86002 (5 x 10(-7)-10(-5) M) markedly inhibited the IL6 release and totally inhibited resorption at all concentrations tested.	amicloral	48-54	interleukin 6	Homo sapiens	108-111
9309381-6	1997	In human osteoblastic cells (SaOS2) both basal and TNF alpha-stimulated IL6 production were inhibited in a concentration-related manner by SK&F 86002 but not by indomethacin.	amicloral	139-145	interleukin 6	Homo sapiens	72-75
9309381-7	1997	The effect of SK&F 86002 was greatest in 6 h cultures where relatively low levels of IL6 are produced and progressively less in 24 and 48 h cultures which produce higher levels of IL6.	amicloral	14-20	interleukin 6	Homo sapiens	89-92
9309381-7	1997	The effect of SK&F 86002 was greatest in 6 h cultures where relatively low levels of IL6 are produced and progressively less in 24 and 48 h cultures which produce higher levels of IL6.	amicloral	14-20	interleukin 6	Homo sapiens	184-187
9309381-9	1997	Therefore, SK&F 86002 may inhibit IL6 production in osteoblastic cells via a more direct mechanism, possibly involving inhibition of the p38 MAP kinase, the mechanism proposed for its inhibition of IL 1 beta and TNF alpha release.	amicloral	11-17	interleukin 6	Homo sapiens	38-41
9309381-9	1997	Therefore, SK&F 86002 may inhibit IL6 production in osteoblastic cells via a more direct mechanism, possibly involving inhibition of the p38 MAP kinase, the mechanism proposed for its inhibition of IL 1 beta and TNF alpha release.	amicloral	11-17	mitogen-activated protein kinase 14	Homo sapiens	141-144
9309381-9	1997	Therefore, SK&F 86002 may inhibit IL6 production in osteoblastic cells via a more direct mechanism, possibly involving inhibition of the p38 MAP kinase, the mechanism proposed for its inhibition of IL 1 beta and TNF alpha release.	amicloral	11-17	interleukin 1 beta	Homo sapiens	202-211
8946652-9	1996	SK&F 86002 blocked the LPS-induced increase in myeloperoxidase activity, indicating a reduction in pulmonary neutrophil infiltration, but had no effect on systemic leukopenia.	amicloral	0-6	myeloperoxidase	Sus scrofa	51-66
8985595-6	1996	Pretreatment with SK&F 96365 prevented thapsigargin from increasing [Ca2+]i, NO production and vWF secretion.	amicloral	18-24	von Willebrand factor	Homo sapiens	99-102
8946652-10	1996	Pretreatment with SK&F 86002 significantly attenuated LPS-induced increases in plasma thromboxane B2 and tumor necrosis factor-alpha.	amicloral	18-24	tumor necrosis factor	Sus scrofa	83-136
7632163-8	1995	The action of fenamates resembled that of the inhibitor of receptor-mediated calcium entry, SK&F 96365, especially when A23187, fMLP or PMA were used to stimulate the cells.	amicloral	92-98	formyl peptide receptor 1	Homo sapiens	132-136
8773410-9	1996	This route of Ca2+ entry is also sensitive to blockade by SK&F 96365.	amicloral	58-64	carbonic anhydrase 2	Canis lupus familiaris	14-17
8991541-2	1996	In this study, we describe the effects of SK&F108636 on highly enriched Lin-Sca1+ hematopoietic stem cells.	amicloral	42-48	caspase 3	Mus musculus	80-84
8991541-5	1996	SK&F108636 significantly inhibited proliferation of high proliferative potential (HPP)-CFC in semisolid agar cultures stimulated by stem cell factor + interleukin 3 (IL-3) + IL-1, but had no effect in cultures stimulated with M-CSF + IL-3 + IL-1.	amicloral	0-6	colony stimulating factor 1 (macrophage)	Mus musculus	230-235
8991541-5	1996	SK&F108636 significantly inhibited proliferation of high proliferative potential (HPP)-CFC in semisolid agar cultures stimulated by stem cell factor + interleukin 3 (IL-3) + IL-1, but had no effect in cultures stimulated with M-CSF + IL-3 + IL-1.	amicloral	0-6	interleukin 3	Mus musculus	170-174
8991541-5	1996	SK&F108636 significantly inhibited proliferation of high proliferative potential (HPP)-CFC in semisolid agar cultures stimulated by stem cell factor + interleukin 3 (IL-3) + IL-1, but had no effect in cultures stimulated with M-CSF + IL-3 + IL-1.	amicloral	0-6	interleukin 1 complex	Mus musculus	245-249
8991541-6	1996	SK&F108636 was shown to act directly on the stem cells since SK&F108636 inhibited proliferation of Lin-Sca1+ cells in single cell assays.	amicloral	0-6	caspase 3	Mus musculus	111-115
8991541-6	1996	SK&F108636 was shown to act directly on the stem cells since SK&F108636 inhibited proliferation of Lin-Sca1+ cells in single cell assays.	amicloral	65-71	caspase 3	Mus musculus	111-115
8991541-7	1996	Administration of SK&F108636 to lethally irradiated mice transplanted with 2000 Lin-Sca1+ cells significantly inhibited proliferation/differentiation of cells developing into colony forming units-spleen (CFU-S) (preCFU-S) and the reconstitution of HPP-CFC and GM-CFC.	amicloral	18-24	caspase 3	Mus musculus	88-92
7503756-10	1995	These data indicate that the duration of action of SK&F 97574 is longer than that of the histamine H2 receptor antagonists such as cimetidine, but shorter than that of covalent (H+/K+)-inhibitors such as omeprazole.	amicloral	51-57	histamine receptor H 2	Rattus norvegicus	93-114
8894140-7	1996	SK&F 96365, an inhibitor of receptor-operated Ca2+ entry, significantly inhibited the choline formation induced by FCS.	amicloral	0-6	carbonic anhydrase 2	Mus musculus	50-53
8702797-5	1996	Of these two chemokines, only Gro-alpha induced an influx of calcium in neutrophils as judged by the sensitivity of the mobilization of calcium to the extracellular calcium chelator EGTA and to the nonselective divalent cation channel inhibitor SK&F 96365, as well as by manganese quenching experiments.	amicloral	245-251	C-X-C motif chemokine ligand 1	Homo sapiens	30-39
8864528-4	1996	In lysates prepared from both subsets, SK&F 95654 (PDE3 inhibitor) and rolipram (PDE4 inhibitor) suppressed cyclic AMP hydrolysis indicating the presence of PDE3 and PDE4 isoenzymes in these cells.	amicloral	39-45	phosphodiesterase 4A	Homo sapiens	170-174
8864528-14	1996	Although inactive alone, SK&F 95654 potentiated the ability of rolipram to suppress PHA- and anti-CD3-induced T-cell proliferation, and PHA-induced IL-2 release.	amicloral	25-31	interleukin 2	Homo sapiens	152-156
9812726-0	1996	SK&F 105494, a V2-vasopressin receptor antagonist, blocks oxytocin receptors in porcine myometrium.	amicloral	0-6	oxytocin/neurophysin I prepropeptide	Homo sapiens	62-70
9812726-1	1996	AIM: To study the effects of SK & F 105494 (SK & F), a V2-vasopressin receptor antagonist, on lypressin (Lyp)- and oxytocin (Oxy)-induced increases in myometrial contractility.	amicloral	29-36	oxytocin/neurophysin I prepropeptide	Homo sapiens	133-136
9812726-5	1996	SK & F 30-300 nmol.L-1 antagonized the contractile effects of Lyp and Oxy in a concentration-dependent manner.	amicloral	0-7	oxytocin/neurophysin I prepropeptide	Homo sapiens	74-77
9812726-6	1996	When the concentration-dependent inhibition of [3H] Oxy binding by SK & F was compared with Lyp and L-366948 [(cyclo-(L-Pro-D-2-naphthyl-Ala-L-lle-D-pipecolic acid-L-pipecolic acid-D-His)], a potent antagonist specific for Oxy receptors, the Ki values for SK & F, Lyp, and L-366948 were 1.73 +/- 0.32, 14.36 +/- 1.73, and 1.79 +/- 0.35 nmol.L-1, respectively.	amicloral	67-74	oxytocin/neurophysin I prepropeptide	Homo sapiens	52-55
9812726-7	1996	CONCLUSION: SK & F has a potent Oxy receptor blocking activity in addition to its known V2-receptor blocking activity.	amicloral	12-19	oxytocin/neurophysin I prepropeptide	Homo sapiens	36-39
7498963-6	1995	Depletion of extracellular Ca2+ or addition of Ca2+ channel blockers (nifedipine, verapamil, SK&F 96365) attenuated ET-1-mediated 6-keto-PGF1 alpha synthesis, while a Ca2+ channel agonist, S(-)-Bay K 8644, potentiated this effect of ET-1.	amicloral	93-99	endothelin 1	Rattus norvegicus	120-124
7498963-6	1995	Depletion of extracellular Ca2+ or addition of Ca2+ channel blockers (nifedipine, verapamil, SK&F 96365) attenuated ET-1-mediated 6-keto-PGF1 alpha synthesis, while a Ca2+ channel agonist, S(-)-Bay K 8644, potentiated this effect of ET-1.	amicloral	93-99	endothelin 1	Rattus norvegicus	237-241
7883027-1	1994	When acetylcholinesterase was inhibited by neostigmine, SK&F 96365 (1-(beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl)-1H-imidazole hydrochloride) at 10 microM caused no effect on the amplitude of single endplate potentials (e.p.p.s) but shortened the decay time in mouse phrenic nerve-diaphragm preparations.	amicloral	56-62	acetylcholinesterase	Mus musculus	5-25
7539326-4	1995	Pretreatment with the PDE IV inhibitors rolipram or Ro 20-1724 or the nonselective PDE inhibitor theophylline 1 h before intratracheal injection of IL-5 significantly reduced the number of eosinophils in the BAL fluid at 48 h. In contrast, the selective PDE III inhibitors milrinone and SK&F 94-836 and the PDE I/V inhibitor zaprinast did not inhibit the airway eosinophil infiltration induced by IL-5.	amicloral	287-293	interleukin 5	Homo sapiens	148-152
7773223-4	1995	Both the marrow GM-CFC progenitor cell population and Mac-1 positive cells in blood were shown to recover faster in recipients of SK&F107647 treated donors.	amicloral	130-136	integrin alpha M	Mus musculus	54-59
7583362-3	1995	Levels of TNF protein were lowered by SK&F 86002 under conditions where TNF mRNA accumulation was unaffected, suggesting a post-transcriptional action.	amicloral	38-44	tumor necrosis factor	Homo sapiens	10-13
7583362-3	1995	Levels of TNF protein were lowered by SK&F 86002 under conditions where TNF mRNA accumulation was unaffected, suggesting a post-transcriptional action.	amicloral	38-44	tumor necrosis factor	Homo sapiens	76-79
7583362-5	1995	The kinetics of SK&F 86002 inhibition of TNF protein synthesis coincided with those of anisomycin, not with actinomycin, suggesting an effect of SK&F 86002 on TNF mRNA translation.	amicloral	16-22	tumor necrosis factor	Homo sapiens	45-48
7583362-5	1995	The kinetics of SK&F 86002 inhibition of TNF protein synthesis coincided with those of anisomycin, not with actinomycin, suggesting an effect of SK&F 86002 on TNF mRNA translation.	amicloral	149-155	tumor necrosis factor	Homo sapiens	167-170
7583362-8	1995	Treatment with lipopolysaccharide plus SK&F 86002 led to a marked accumulation of TNF mRNA in the 43S complex-containing fractions and a concomitant reduction of polysome-associated TNF message.	amicloral	39-45	tumor necrosis factor	Homo sapiens	86-89
7583362-8	1995	Treatment with lipopolysaccharide plus SK&F 86002 led to a marked accumulation of TNF mRNA in the 43S complex-containing fractions and a concomitant reduction of polysome-associated TNF message.	amicloral	39-45	tumor necrosis factor	Homo sapiens	186-189
7947609-5	1994	Autacoids released by histamine-stimulated endothelial cells caused the phosphorylation of rap1B and VASP in platelets, which was only partly inhibited by either indomethacin or NG-monomethyl-L-arginine but was almost completely suppressed by SK&F 96365.	amicloral	243-249	RAP1B, member of RAS oncogene family	Homo sapiens	91-96
7947609-7	1994	The results demonstrate that blockade of receptor-mediated calcium entry by SK&F 96365 markedly reduced the release of biologically active prostacyclin and EDRF from endothelial cells.	amicloral	76-82	alpha hemoglobin stabilizing protein	Homo sapiens	160-164
7858878-0	1994	Inhibition by SK&F 96365 of Ca2+ current, IL-2 production and activation in T lymphocytes.	amicloral	14-20	interleukin 2	Homo sapiens	46-50
7858878-9	1994	The ability of SK&F 96365 to inhibit IL-2 synthesis and cell proliferation suggests that a new class of related Ca2+ channel blockers can be developed as immunosuppressive agents.	amicloral	15-21	interleukin 2	Homo sapiens	41-45
7521569-2	1994	Mediators released from mast cells in immune animals challenged with beta-lactoglobulin evoked an increase in short-circuit current that was reduced by SK&F 102922, a peptidoleukotriene antagonist.	amicloral	152-158	beta-lactoglobulin	Bos taurus	69-87
7705461-7	1994	Both endothelin-1- and endothelin-3-induced 45Ca2+ uptake were inhibited by receptor operated Ca2+ channel blocker SK&F 96365, whereas they were insensitive to dihydropyridine derivatives nifedipine and nitrendipine.	amicloral	115-121	endothelin 1	Rattus norvegicus	5-17
7705461-7	1994	Both endothelin-1- and endothelin-3-induced 45Ca2+ uptake were inhibited by receptor operated Ca2+ channel blocker SK&F 96365, whereas they were insensitive to dihydropyridine derivatives nifedipine and nitrendipine.	amicloral	115-121	endothelin 3	Rattus norvegicus	23-35
7705461-8	1994	The release of arachidonic acid from rat brain endothelial cells observed in response to endothelin-1 was inhibited by ryanodine or SK&F 96365, implicating participation of both intra- and extra- cellular components of Ca2+ signaling in activating endothelial secretion of vasoactive substances.	amicloral	132-138	endothelin 1	Rattus norvegicus	89-101
7980964-3	1994	In the present study, SK&F 86002 inhibited fetal rat long bone (FRLB) resorption induced by parathyroid hormone (PTH), 1,25-dihydroxy-vitamin D3, tumor necrosis factor alpha, and Escherichia coli lipopolysaccharide in a dose-dependent (IC50 of 0.5-1 microM) and reversible manner.	amicloral	22-28	parathyroid hormone	Rattus norvegicus	96-115
7980964-3	1994	In the present study, SK&F 86002 inhibited fetal rat long bone (FRLB) resorption induced by parathyroid hormone (PTH), 1,25-dihydroxy-vitamin D3, tumor necrosis factor alpha, and Escherichia coli lipopolysaccharide in a dose-dependent (IC50 of 0.5-1 microM) and reversible manner.	amicloral	22-28	tumor necrosis factor	Rattus norvegicus	150-177
8063786-11	1994	As an independent verification of specificity, a marked reduction in MMP-2 gelatinase activity by zymogram was shown after treatment of A2058 cells with SK&F 96365, an unrelated inhibitor of receptor-operated calcium influx.	amicloral	153-159	matrix metallopeptidase 2	Homo sapiens	69-74
8057281-3	1994	We have shown that known GABA uptake inhibitors such as SK&F 89976-A, CI-966, and Tiagabine exhibit high affinity and selectivity for GAT-1.	amicloral	56-62	solute carrier family 6 member 1	Homo sapiens	138-143
8072241-4	1994	In a second series of experiments, a selective 5-lipoxygenase (5-LO) inhibitor, SK&F 107649, was used to investigate the involvement of 5-LO products in the pathophysiology of anti-GBM antibody-induced glomerulonephritis.	amicloral	80-86	arachidonate 5-lipoxygenase	Rattus norvegicus	47-61
7851497-0	1994	Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.	amicloral	11-17	solute carrier family 6 member 1	Homo sapiens	95-100
7965744-4	1994	AII-stimulated endothelin (ET)-1 gene expression was antagonized by SK&F 108566 (50% at 1 microM), but not by selective AT2 receptor antagonists.	amicloral	68-74	angiotensinogen	Rattus norvegicus	0-3
7965744-5	1994	Similarly, AII stimulated the release of immunoreactive ET (irET) from cultured VSM cells that was antagonized by 1 microM SK&F 108566 (72%) and DuP 753 (66%), but not by AT2 receptor antagonists.	amicloral	123-129	angiotensinogen	Rattus norvegicus	11-14
7965744-7	1994	AII (1-100 nM) markedly (6- to 10-fold) stimulated mitogen-activated protein kinase, an enzyme believed to be involved in the pathway for cell proliferation, and this stimulation was blocked (50-75%) by SK&F 108566 (1 nM-1 microM).	amicloral	203-209	angiotensinogen	Rattus norvegicus	0-3
7980964-2	1994	SK&F 86002 [5-(4-pyridyl)-6(4-fluorophenyl)-2,3-dihydroimidazo(2,1-b) thiazole], a potent cytokine-suppressive anti-inflammatory agent, has been shown to inhibit cyclooxygenase (CO) and 5-lipoxygenase (LO) activity and to inhibit the production of cytokines both in vitro and in vivo.	amicloral	0-6	arachidonate 5-lipoxygenase	Rattus norvegicus	190-204
8038206-2	1994	Gd3+ and SK&F 96365 inhibited Ca2+ and Mn2+ inflow stimulated by vasopressin, angiotensin II or phenylephrine.	amicloral	9-15	arginine vasopressin	Homo sapiens	69-80
8038206-2	1994	Gd3+ and SK&F 96365 inhibited Ca2+ and Mn2+ inflow stimulated by vasopressin, angiotensin II or phenylephrine.	amicloral	9-15	angiotensinogen	Homo sapiens	82-96
8038206-3	1994	The concentrations of Gd3+ and SK&F 96365 which gave half-maximal inhibition of vasopressin-stimulated Ca2+ inflow were 2 x 10(-7) M and 16 x 10(-6) M, respectively.	amicloral	31-37	arginine vasopressin	Homo sapiens	84-95
7974388-5	1994	SK&F 106760 inhibited biotinylated fibrinogen binding to purified human GPIIb/IIIa immobilized on plastic microtitre plates with a Ki of 477 +/- 57 pM.	amicloral	0-6	fibrinogen beta chain	Homo sapiens	39-49
7974388-5	1994	SK&F 106760 inhibited biotinylated fibrinogen binding to purified human GPIIb/IIIa immobilized on plastic microtitre plates with a Ki of 477 +/- 57 pM.	amicloral	0-6	integrin subunit alpha 2b	Homo sapiens	76-81
7974388-9	1994	SK&F 106760 produced insurmountable inhibition of adenosine diphosphate-induced platelet aggregation in the presence of constant fibrinogen concentrations, but produced competitive inhibition of the concentration-response curve to fibrinogen in adenosine diphosphate-activated platelets with a Kb of 8.0 +/- 1.0 nM.	amicloral	0-6	fibrinogen beta chain	Homo sapiens	235-245
7915128-1	1994	SK&F 87516 is a potent DA1 receptor agonist with demonstrated renal vasodilator activity.	amicloral	0-6	RT1 class II, locus Da	Rattus norvegicus	27-30
8183249-8	1994	SK&F104856 was found to be 6-fold more potent at the alpha 1a/d receptor subtype than at alpha 1b- or alpha 1c-adrenergic receptors.	amicloral	0-6	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	57-65
8012704-10	1994	Concentrations of SK&F 103829 causing greater than threshold constrictions enhanced vasoconstrictor responses of sympathetic nerve stimulation, noradrenaline, angiotensin II, methoxamine and alpha, beta-methylene ATP in the mesenteric arterial bed.	amicloral	18-24	angiotensinogen	Rattus norvegicus	163-200
8012704-13	1994	Ketanserin prevented both the constrictor effect of SK&F 103829 and the SK&F 103829-evoked potentiation of the responses to noradrenaline and angiotensin II in the mesenteric arterial bed.	amicloral	76-82	angiotensinogen	Rattus norvegicus	150-164
7915128-2	1994	SK&F 87516 is the 6-fluoro analog of another DA1 agonist/renal vasodilator agent, fenoldopam.	amicloral	0-6	RT1 class II, locus Da	Rattus norvegicus	49-52
8149896-0	1994	Disposition of growth hormone-releasing peptide (SK&F 110679) in rat and dog following intravenous or subcutaneous administration.	amicloral	49-55	ghrelin and obestatin prepropeptide	Rattus norvegicus	15-47
8035652-6	1994	The secondary phase of aggregation produced by human laminin in "responsive" individuals was abolished by aspirin, SQ 29,548, a selective thromboxane antagonist, and SK&F 106760, an RGD-derived platelet fibrinogen receptor (GPIIb/IIIa) antagonist.	amicloral	166-172	integrin subunit alpha 2b	Homo sapiens	228-233
8264564-7	1993	The idea that CYP2B1 was involved in the one-electron reduction of ADR in PB microsomes and in reconstituted systems of purified CYP2B1 and purified NADPH-CYP reductase (RED) under anaerobic conditions could be concluded from inhibition studies using SK&F 525-A and antibodies (KO1) against CYP2B enzymes.	amicloral	251-257	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	14-20
7507780-5	1993	The combination of the peptidoleukotriene receptor antagonist, SK&F 104353 (10 microM) and the H1-histamine receptor antagonist, mepyramine (10 microM), which abolishes antigen-induced contraction in guinea-pig trachea, was without effect on ET-1 concentration-response curves.	amicloral	63-69	endothelin-1	Cavia porcellus	246-250
8516808-6	1993	SK&F 105685 therapy diminished the immunohistological features of acute rejection, with the cellular infiltrate suppressed and the induction of IL-2/transferrin receptors, and elaboration of IL-2/IFN-gamma essentially abolished, as compared with the grafts in untreated hosts.	amicloral	0-6	interleukin 2	Rattus norvegicus	148-152
8402579-1	1993	SK&F 96365, a reported receptor-operated Ca2+ channel blocker, inhibited the growth of U-373 MG human astrocytoma and SK-N-MC human neuroblastoma cell lines in a dose-dependent manner.	amicloral	0-6	carbonic anhydrase 2	Homo sapiens	45-48
8402579-4	1993	These results suggest that SK&F 96365 is a potent inhibitor of brain tumor cell growth and that its effect may be mediated by the inhibition of agonist-induced intracellular Ca2+ mobilization.	amicloral	27-33	carbonic anhydrase 2	Homo sapiens	178-181
8516808-6	1993	SK&F 105685 therapy diminished the immunohistological features of acute rejection, with the cellular infiltrate suppressed and the induction of IL-2/transferrin receptors, and elaboration of IL-2/IFN-gamma essentially abolished, as compared with the grafts in untreated hosts.	amicloral	0-6	interleukin 2	Rattus norvegicus	195-199
8516808-6	1993	SK&F 105685 therapy diminished the immunohistological features of acute rejection, with the cellular infiltrate suppressed and the induction of IL-2/transferrin receptors, and elaboration of IL-2/IFN-gamma essentially abolished, as compared with the grafts in untreated hosts.	amicloral	0-6	interferon gamma	Rattus norvegicus	200-209
8435086-17	1993	Finally, use of fura-2 and SK&F 96365 to manipulate the fMLP-stimulated rise in [Ca2+]i showed that when fMLP was able to evoke its normal rise in [Ca2+]i (to a peak of 700-900 nM), O2-.	amicloral	27-33	formyl peptide receptor 1	Homo sapiens	60-64
8097163-2	1993	This compound induced the same intense grooming behaviour identified previously as a characteristic response to typical dopamine D1 receptor agonists such as SK&F 77434 that stimulate adenylyl cyclase; it also induced vacuous chewing.	amicloral	158-164	dopamine receptor D1	Homo sapiens	120-140
8435086-17	1993	Finally, use of fura-2 and SK&F 96365 to manipulate the fMLP-stimulated rise in [Ca2+]i showed that when fMLP was able to evoke its normal rise in [Ca2+]i (to a peak of 700-900 nM), O2-.	amicloral	27-33	formyl peptide receptor 1	Homo sapiens	109-113
7682199-0	1993	Inhibition of CD44, CD45 and LFA-3 mediated cytokine release from human monocytes by SK&F 86002 and pentoxifylline.	amicloral	85-91	CD44 molecule (Indian blood group)	Homo sapiens	14-18
7682199-0	1993	Inhibition of CD44, CD45 and LFA-3 mediated cytokine release from human monocytes by SK&F 86002 and pentoxifylline.	amicloral	85-91	protein tyrosine phosphatase receptor type C	Homo sapiens	20-24
7682199-0	1993	Inhibition of CD44, CD45 and LFA-3 mediated cytokine release from human monocytes by SK&F 86002 and pentoxifylline.	amicloral	85-91	CD58 molecule	Homo sapiens	29-34
7682199-1	1993	Compounds from two distinct pharmacological classes namely, SK&F 86002 and pentoxifylline, were examined for their effects on TNF alpha and IL-1 beta release by human monocytes stimulated with LPS or monoclonal antibodies to three cell surface glycoproteins, CD44, CD45 and LFA-3 (LFA-3 is also known as CD58).	amicloral	60-66	tumor necrosis factor	Homo sapiens	130-139
7682199-1	1993	Compounds from two distinct pharmacological classes namely, SK&F 86002 and pentoxifylline, were examined for their effects on TNF alpha and IL-1 beta release by human monocytes stimulated with LPS or monoclonal antibodies to three cell surface glycoproteins, CD44, CD45 and LFA-3 (LFA-3 is also known as CD58).	amicloral	60-66	interleukin 1 beta	Homo sapiens	144-153
7682199-2	1993	SK&F 86002, an inhibitor of 5-LO and CO in arachidonic acid metabolism, inhibited LPS-induced release of TNF alpha and IL-1 beta with an IC50 of 1 microM.	amicloral	0-6	tumor necrosis factor	Homo sapiens	109-118
7682199-2	1993	SK&F 86002, an inhibitor of 5-LO and CO in arachidonic acid metabolism, inhibited LPS-induced release of TNF alpha and IL-1 beta with an IC50 of 1 microM.	amicloral	0-6	interleukin 1 beta	Homo sapiens	123-132
7682199-6	1993	These results suggest that (a) LPS induced cytokine release shares a common step with the physiologically relevant stimuli (involving cross-linking of cell surface receptors), and that this pathway is sensitive to inhibition by SK&F 86002 and, (b) SK&F 86002 is more potent than pentoxifylline in inhibiting TNF alpha and IL-1 beta release induced by both stimuli.	amicloral	228-234	tumor necrosis factor	Homo sapiens	316-325
7682199-6	1993	These results suggest that (a) LPS induced cytokine release shares a common step with the physiologically relevant stimuli (involving cross-linking of cell surface receptors), and that this pathway is sensitive to inhibition by SK&F 86002 and, (b) SK&F 86002 is more potent than pentoxifylline in inhibiting TNF alpha and IL-1 beta release induced by both stimuli.	amicloral	228-234	interleukin 1 beta	Homo sapiens	330-339
7682199-6	1993	These results suggest that (a) LPS induced cytokine release shares a common step with the physiologically relevant stimuli (involving cross-linking of cell surface receptors), and that this pathway is sensitive to inhibition by SK&F 86002 and, (b) SK&F 86002 is more potent than pentoxifylline in inhibiting TNF alpha and IL-1 beta release induced by both stimuli.	amicloral	252-258	tumor necrosis factor	Homo sapiens	316-325
7682199-6	1993	These results suggest that (a) LPS induced cytokine release shares a common step with the physiologically relevant stimuli (involving cross-linking of cell surface receptors), and that this pathway is sensitive to inhibition by SK&F 86002 and, (b) SK&F 86002 is more potent than pentoxifylline in inhibiting TNF alpha and IL-1 beta release induced by both stimuli.	amicloral	252-258	interleukin 1 beta	Homo sapiens	330-339
8273586-2	1993	In vitro, SK&F 86002 inhibited LPS stimulated TNF-alpha production by the RAW 264.7 cell line and by oil elicited peritoneal macrophages with an IC50 of 5 microM.	amicloral	10-16	tumor necrosis factor	Mus musculus	50-59
8273586-5	1993	Following oral administration, SK&F 86002 and its analogs reduced serum TNF-alpha levels by > 80% and afforded 100% protection from lethality.	amicloral	31-37	tumor necrosis factor	Mus musculus	76-85
8273589-1	1993	The mechanism by which SK&F 86002 and other pyridinyl imidazoles inhibit the production of IL-1 and TNF from LPS-stimulated human monocytes was examined.	amicloral	23-29	interleukin 1 beta	Homo sapiens	95-99
8273589-1	1993	The mechanism by which SK&F 86002 and other pyridinyl imidazoles inhibit the production of IL-1 and TNF from LPS-stimulated human monocytes was examined.	amicloral	23-29	tumor necrosis factor	Homo sapiens	104-107
8273589-2	1993	Inhibition of IL-1 and TNF production was found to depend on the time of addition of SK&F 86002, with diminishing effect when added more than 2 h after LPS stimulation.	amicloral	85-91	interleukin 1 beta	Homo sapiens	14-26
8273589-3	1993	Analysis of Western blots confirmed that both intracellular IL-1 beta and extracellular TNF were significantly reduced in response to SK&F 86002, but these reductions were not paralleled by changes in IL-1 and TNF mRNA.	amicloral	134-140	interleukin 1 beta	Homo sapiens	60-69
8273589-3	1993	Analysis of Western blots confirmed that both intracellular IL-1 beta and extracellular TNF were significantly reduced in response to SK&F 86002, but these reductions were not paralleled by changes in IL-1 and TNF mRNA.	amicloral	134-140	tumor necrosis factor	Homo sapiens	88-91
8273589-3	1993	Analysis of Western blots confirmed that both intracellular IL-1 beta and extracellular TNF were significantly reduced in response to SK&F 86002, but these reductions were not paralleled by changes in IL-1 and TNF mRNA.	amicloral	134-140	interleukin 1 beta	Homo sapiens	60-64
8273589-4	1993	35S methionine pulse and pulse-chase studies on IL-1 biosynthesis suggest that significant inhibition by SK&F 86002 and related compounds occurs at the translational level.	amicloral	105-111	interleukin 1 beta	Homo sapiens	48-52
1281979-10	1992	SK&F 96365 inhibited fMLP- and ATP-stimulated currents with a half-maximal effect at about 3 microM.	amicloral	0-6	formyl peptide receptor 1	Homo sapiens	25-29
8275798-4	1993	In contrast, SK&F 96365, which is an inhibitor of receptor-operated calcium channel, blocked the PAF-elicited Ca(2+)-response dose-dependently.	amicloral	13-19	patchy fur	Mus musculus	101-104
8013267-7	1993	The CSAID (exemplified by SK&F 86002, SK&F 105809 and SK&F 104351), strongly inhibited TNF alpha production in this model system (ED50s of 32, 48, and 34 mg/kg p.o., respectively).	amicloral	26-32	tumor necrosis factor	Mus musculus	99-108
1281979-18	1992	SK&F 96365 inhibited fMLP-induced beta-glucuronidase release and O2- production in the presence of both Ca2+ and Na+, and in the presence of Ca2+ or Na+ alone.	amicloral	0-6	formyl peptide receptor 1	Homo sapiens	25-29
1281979-18	1992	SK&F 96365 inhibited fMLP-induced beta-glucuronidase release and O2- production in the presence of both Ca2+ and Na+, and in the presence of Ca2+ or Na+ alone.	amicloral	0-6	glucuronidase beta	Homo sapiens	38-56
1326953-4	1992	In contrast, SK&F 96365 a purported receptor operated calcium channel (ROCC) inhibitor, and its parent compound SC 32849, attenuated LTB4 induced [Ca++]i.	amicloral	13-19	prostaglandin reductase 1	Cavia porcellus	137-141
1422592-2	1992	SK&F 95654 inhibited the guanosine 3":5"-cyclic monophosphate (cyclic GMP)-inhibited phosphodiesterase (cGI-PDE) with an IC50 value of 0.7 microM.	amicloral	0-6	phosphodiesterase 3A	Homo sapiens	108-115
1422592-4	1992	The R-enantiomer of SK&F 95654 (IC50 = 0.35 microM) was a more potent inhibitor of cGI-PDE than was the S-enantiomer (IC50 = 5.3 microM).	amicloral	20-26	phosphodiesterase 3A	Homo sapiens	87-94
1422592-12	1992	SK&F 95654 caused a potent inhibition of U46619-induced aggregation in both a human washed platelet suspension (WPS) (IC50 = 70 nM) and in human platelet-rich plasma (PRP) (IC50 = 60 nM), indicating that the compound shows negligible plasma binding.	amicloral	0-6	proline rich protein 2-like 1	Rattus norvegicus	171-174
1422592-15	1992	The similarity of this ratio to that obtained on the cGI-PDE suggests that SK&F 95654 inhibits platelet aggregation via its effects on cGI-PDE.	amicloral	75-81	phosphodiesterase 3A	Homo sapiens	53-60
1422592-15	1992	The similarity of this ratio to that obtained on the cGI-PDE suggests that SK&F 95654 inhibits platelet aggregation via its effects on cGI-PDE.	amicloral	75-81	phosphodiesterase 3A	Homo sapiens	139-146
1422592-18	1992	Collagen-induced aggregation of rat PRP was also inhibited by SK&F 95654 (ICso = 65 nM).	amicloral	62-68	proline rich protein 2-like 1	Rattus norvegicus	36-39
1330154-14	1992	Preincubation of the cells with EGTA, verapamil, or the receptor-operated calcium channel antagonist, SK&F 96365, reduced vasopressin-stimulated [3H]-PtdBuOH accumulation by approximately 30%, suggesting that influx of calcium has a significant role to play in the regulation of vasopressinstimulated PLD activity.	amicloral	102-108	arginine vasopressin	Homo sapiens	126-137
1330154-14	1992	Preincubation of the cells with EGTA, verapamil, or the receptor-operated calcium channel antagonist, SK&F 96365, reduced vasopressin-stimulated [3H]-PtdBuOH accumulation by approximately 30%, suggesting that influx of calcium has a significant role to play in the regulation of vasopressinstimulated PLD activity.	amicloral	102-108	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	305-308
1510680-5	1992	Thus biosynthesis and release of EDRF from human umbilical vein endothelial cells significantly depend on agonist-induced Ca2+ entry involving receptor-operated Ca(2+)-permeable channels which can be blocked by SK&F 96365.	amicloral	211-217	alpha hemoglobin stabilizing protein	Homo sapiens	33-37
1446388-3	1992	We report here that in vitro SK&F 105561 also blocks the production of tumor necrosis factor (TNF) from human monocytes (IC50 0.8-3 microM).	amicloral	29-35	tumor necrosis factor	Homo sapiens	75-96
1446388-3	1992	We report here that in vitro SK&F 105561 also blocks the production of tumor necrosis factor (TNF) from human monocytes (IC50 0.8-3 microM).	amicloral	29-35	tumor necrosis factor	Homo sapiens	98-101
1355296-1	1992	The effects of dynorphin A(1-13) on the D1 dopamine agonist SK&F 38393- and the D2 dopamine agonist RU 24213-induced behavioral alterations in the mouse were determined by using multidimensional behavioral analyses based upon a capacitance system.	amicloral	60-66	prodynorphin	Mus musculus	15-31
1356721-10	1992	These data indicate that M3a and M3b are nonglycosidic isomers of M2 that were formed by a nonenzymic reaction involving migration of the aglycone (SK&F 102922) from C-1 to C-2, C-3, or C-4 of glucuronic acid.	amicloral	148-154	complement C2	Cavia porcellus	170-185
1635591-2	1992	SK&F 108566 produced dose-dependent decreases in blood pressure in renin-dependent hypertensive rats.	amicloral	0-6	renin	Rattus norvegicus	71-76
1348448-0	1992	Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue.	amicloral	87-93	ATP binding cassette subfamily B member 1	Homo sapiens	10-24
1591653-1	1992	The purpose of this study was to determine if a structurally novel dual inhibitor of arachidonic acid metabolism, SK & F 86002, would inhibit the endotoxin-induced production of tumor necrosis factor (TNF) activity by equine peritoneal macrophages.	amicloral	114-121	tumor necrosis factor	Equus caballus	182-203
1591653-1	1992	The purpose of this study was to determine if a structurally novel dual inhibitor of arachidonic acid metabolism, SK & F 86002, would inhibit the endotoxin-induced production of tumor necrosis factor (TNF) activity by equine peritoneal macrophages.	amicloral	114-121	tumor necrosis factor	Equus caballus	205-208
1591653-7	1992	Coincubation of macrophages with SK & F 86002 significantly decreased the subsequent supernatant TNF activity.	amicloral	33-40	tumor necrosis factor	Equus caballus	101-104
1591653-8	1992	Concentrations of SK & F 86002 from 10(-7) to 10(-4) molar effectively reduced TNF production when added to macrophages 0 and 0.5 h prior to endotoxin.	amicloral	18-25	tumor necrosis factor	Equus caballus	83-86
1591653-9	1992	After 2 h of preincubation, SK & F 86002 significantly reduced supernatant TNF activity at 10(-5) and 10(-4) M concentrations.	amicloral	28-35	tumor necrosis factor	Equus caballus	79-82
1560388-2	1992	We therefore investigated the effect of inhibition of the renin-angiotensin system by SK&F 108566, a novel, nonpeptide angiotensin II (AII) receptor antagonist, or by enalapril, an angiotensin converting enzyme inhibitor, on glycine-induced hyperfiltration.	amicloral	86-92	renin	Rattus norvegicus	58-63
1312215-13	1992	SK&F 96365 at 30 microM inhibited MTX-induced insulin release by 75%, whereas nifedipine, even at 30 microM, inhibited release by only 10%.	amicloral	0-6	insulin	Homo sapiens	50-57
2050194-6	1991	PCP, (+)-SK&F 10047 and (+/-)-pentazocine probably enhance neurogenic contractions in rat vas deferens primarily by inhibition of the neuronal uptake of noradrenaline.	amicloral	5-15	arginine vasopressin	Rattus norvegicus	94-97
1683559-2	1991	Ropinirole, SK&F 101468 has been characterized preclinically as a specific dopamine D2-receptor agonist.	amicloral	12-18	dopamine receptor D2	Homo sapiens	79-99
1907824-0	1991	Pharmacology of the pyrroloimidazole, SK&F 105809--I. Inhibition of inflammatory cytokine production and of 5-lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.	amicloral	38-44	arachidonate 5-lipoxygenase	Homo sapiens	112-126
1907825-8	1991	The impact of inhibition of both 5-lipoxygenase (5-LO) and CO was seen with platelet-activating factor-induced vascular permeability which was inhibited markedly by SK&F 105809.	amicloral	165-171	arachidonate 5-lipoxygenase	Mus musculus	33-47
1292522-5	1992	However, SK&F 95587 reduced mesenteric vasoconstrictor responses to PGD2.	amicloral	9-15	prostaglandin D2 synthase	Homo sapiens	72-76
1292522-6	1992	Results of the present study indicate that SK&F 95587 blocks TX-receptor-mediated responses in the hindquarters circulation of the cat in a competitive and selective manner and reduces mesenteric vascular responses to the TXA2 mimics, as well as PGD2.	amicloral	43-49	prostaglandin D2 synthase	Homo sapiens	250-254
1309870-0	1992	Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566.	amicloral	87-93	angiotensinogen	Rattus norvegicus	51-65
1309870-9	1992	administration of SK&F 108566 (0.01-0.3 mg/kg) produced dose-dependent parallel shifts in the AII pressor dose-response curve.	amicloral	18-24	angiotensinogen	Rattus norvegicus	98-101
1309870-10	1992	Administration of SK&F 108566 (3-10 mg/kg) intraduodenally or intragastrically to conscious normotensive rats resulted in a dose-dependent inhibition of the pressor response to AII (250 ng/kg, i.v.).	amicloral	18-24	angiotensinogen	Rattus norvegicus	181-184
1309870-13	1992	The data demonstrate that SK&F 108566 is a potent, highly selective, competitive nonpeptide AII antagonist.	amicloral	26-32	angiotensinogen	Rattus norvegicus	96-99
1684820-6	1991	Administration of the vasopressin receptor antagonist, SK&F 105494, to either dogs or cynomolgus monkeys demonstrated that antagonism of the vasopressin V2 receptor could result in a brisk water diuresis in both species.	amicloral	55-61	arginine vasopressin	Rattus norvegicus	22-33
1684820-6	1991	Administration of the vasopressin receptor antagonist, SK&F 105494, to either dogs or cynomolgus monkeys demonstrated that antagonism of the vasopressin V2 receptor could result in a brisk water diuresis in both species.	amicloral	55-61	arginine vasopressin	Rattus norvegicus	145-156
2059205-0	1991	SK&F 96365, a receptor-mediated calcium entry inhibitor, inhibits calcium responses to endothelin-1 in NG108-15 cells.	amicloral	0-6	endothelin 1	Mus musculus	91-103
2059205-2	1991	Since SK&F 96365 has recently been reported to inhibit receptor-mediated Ca2+ entry in other systems, we examined its effect on intracellular Ca2+ responses to endothelin-1, measured with the fluorescent Ca2+ indicator fura-2, in NG108-15 cells.	amicloral	6-12	endothelin 1	Mus musculus	164-176
2263673-1	1990	The acute and chronic effects of a potent and selective dopamine beta-hydroxylase inhibitor, SK&F 102698 [1-(3,5-difluorobenzyl)imidazole-2-thiol], on systemic hemodynamic variables were assessed in chronically instrumented spontaneously hypertensive and normotensive Wistar rats.	amicloral	93-99	dopamine beta-hydroxylase	Rattus norvegicus	56-81
1663380-7	1991	In pigs pretreated with SK & F104353 the MAP and RABF were transiently improved (P less than 0.05), and the decrease in arterial PO2 was delayed.	amicloral	24-31	PO2	Sus scrofa	133-136
1775514-0	1991	Effect of the dopamine beta-hydroxylase inhibitor, SK&F 102698, on blood pressure in the 1-kidney, 1-clip hypertensive dog.	amicloral	51-57	dopamine beta-hydroxylase	Canis lupus familiaris	14-39
1775514-1	1991	The acute and chronic effects of a potent selective dopamine beta-hydroxylase inhibitor, SK&F 102698, were assessed in chronically instrumented 1-kidney, 1-clip Goldblatt hypertensive dogs.	amicloral	89-95	dopamine beta-hydroxylase	Canis lupus familiaris	52-77
1663268-1	1991	This study characterized the induction of the rat hepatic cytochrome P-450-dependent mixed function oxidase system by SK&F 86002 [6-(4"-fluorophenyl)-5-(4"-pyridyl)-2,3-dihydroimidazo-(2,1-b)thia zole], an inhibitor of both the cyclooxygenase and 5-lipoxygenase pathways of arachidonic acid metabolism.	amicloral	118-124	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	58-74
1663268-1	1991	This study characterized the induction of the rat hepatic cytochrome P-450-dependent mixed function oxidase system by SK&F 86002 [6-(4"-fluorophenyl)-5-(4"-pyridyl)-2,3-dihydroimidazo-(2,1-b)thia zole], an inhibitor of both the cyclooxygenase and 5-lipoxygenase pathways of arachidonic acid metabolism.	amicloral	118-124	arachidonate 5-lipoxygenase	Rattus norvegicus	251-265
2081508-8	1990	Pretreatment with an aerosol of the specific LTD4 receptor antagonist SK&F 104353-Z2 produced a dose-dependent inhibition of the changes in both the airway resistance and GFV.	amicloral	70-76	cysteinyl leukotriene receptor 1	Cavia porcellus	45-58
2173565-5	1990	producing 50% inhibition) for inhibition of RMCE by SK&F 96365 in platelets stimulated with ADP or thrombin was 8.5 microM or 11.7 microM respectively; these concentrations of SK&F 96365 did not affect internal Ca2+ release.	amicloral	52-58	prothrombin	Oryctolagus cuniculus	103-111
1982058-1	1990	Fenoldopam (SK&F 82526) is a potent and selective dopamine DA-1 agonist with demonstrated renal vasodilator and antihypertensive activities in experimental animals and humans.	amicloral	12-18	immunoglobulin heavy diversity 4-11 (non-functional)	Homo sapiens	63-67
1982058-6	1990	The renal and systemic vasodilator properties of SK&F R-82526 are antagonized in a competitive fashion by the DA-1 antagonist, SK&F R-83566, but not the DA-2 antagonist, domperidone.	amicloral	49-55	immunoglobulin heavy diversity 4-11 (non-functional)	Homo sapiens	114-118
1982058-6	1990	The renal and systemic vasodilator properties of SK&F R-82526 are antagonized in a competitive fashion by the DA-1 antagonist, SK&F R-83566, but not the DA-2 antagonist, domperidone.	amicloral	131-137	immunoglobulin heavy diversity 4-11 (non-functional)	Homo sapiens	114-118
1982058-8	1990	Thus, the mechanism of SK&F R-82526-associated vasodilation, like that previously established for fenoldopam, is via stimulation of postganglionic DA-1 receptors.	amicloral	23-29	immunoglobulin heavy diversity 4-11 (non-functional)	Homo sapiens	151-155
2083145-0	1990	Calmodulin discriminates between the two enantiomers of the receptor-operated calcium channel blocker SK&F 96365: a study using 1H-NMR and chiral HPLC.	amicloral	102-108	calmodulin 1	Homo sapiens	0-10
2083145-1	1990	1H nuclear magnetic resonance at 360 MHz shows that SK&F 96365 (1-(beta-[3-(p-methoxyphenyl)-propyloxy]-p-methoxyphenethyl)-1H- imidazole hydrochloride), an antagonist of mammalian receptor-operated calcium channels, interacts with the calcium-binding regulatory protein calmodulin (CaM).	amicloral	52-58	calmodulin 1	Homo sapiens	275-285
2083145-1	1990	1H nuclear magnetic resonance at 360 MHz shows that SK&F 96365 (1-(beta-[3-(p-methoxyphenyl)-propyloxy]-p-methoxyphenethyl)-1H- imidazole hydrochloride), an antagonist of mammalian receptor-operated calcium channels, interacts with the calcium-binding regulatory protein calmodulin (CaM).	amicloral	52-58	calmodulin 1	Homo sapiens	287-290
2405151-11	1990	The pressor effects of ET-1 were reduced by diltiazem, nitrendipine, verapamil or cromakalim and unchanged after BW 755c, desipramine, enalapril, indomethacin, methysergide, phentolamine or SK&F 100273.	amicloral	190-196	endothelin 1	Rattus norvegicus	23-27
2306207-9	1990	Similarly, blockade of the early phase of Ca2+ entry by SK&F 96365 further delays the second phase.	amicloral	56-62	carbonic anhydrase 2	Homo sapiens	42-45
2153809-2	1990	SK&F 94120 (1-10 microM) potentiated relaxation induced by isoproterenol, vasoactive intestinal peptide (VIP) and electrical field stimulation (EFS) in the presence of atropine and propranolol but had no effect on relaxation induced by sodium nitroprusside.	amicloral	0-6	VIP peptides	Cavia porcellus	109-112
1688665-1	1990	SK&F 101926, a synthetic peptide, is a potent antagonist of vasopressin at both the V2 and the V1 receptors.	amicloral	0-6	arginine vasopressin	Rattus norvegicus	64-75
2577500-3	1989	There was also a sustained and significant 80% rise in median 24-h integrated plasma-gastrin concentration during dosing with SK&F 94482 (364 pmol h/L) when compared with placebo (202 pmol h/L; P = 0.003).	amicloral	126-132	gastrin	Homo sapiens	85-92
2559032-7	1989	The 5-lipoxygenase inhibitors, SK&F 86002, SK&F 104493, and phenidone inhibited LTB4 production in vivo as well as inflammatory cell infiltration induced by arachidonic acid.	amicloral	31-37	arachidonate 5-lipoxygenase	Mus musculus	4-18
2574051-2	1989	SK&F 101468, a non phenolic indolone derivative, has been characterised preclinically as a novel, potent and specific dopamine D2-receptor agonist.	amicloral	0-6	dopamine receptor D2	Homo sapiens	122-142
2571297-8	1989	SK&F 83566-C, a selective DA1 dopaminergic receptor antagonist, prevented the induction of FM and dopamine-induced hemorrhagic lesions of large caliber arteries.	amicloral	0-6	RT1 class II, locus Da	Rattus norvegicus	30-33
2571511-0	1989	The alpha 2-adrenoceptor antagonist SK&F 104078 has high affinity for 5-HT1A and 5-HT2 receptors.	amicloral	36-42	5-hydroxytryptamine receptor 1A	Rattus norvegicus	74-86
2571511-1	1989	The affinity of SK&F 104078, a putative selective postjunctional alpha 2-adrenoceptor antagonist, was determined at 5-HT1A and 5-HT2 receptors in rat brain.	amicloral	16-22	5-hydroxytryptamine receptor 1A	Rattus norvegicus	120-132
2570079-0	1989	Application of thermospray liquid chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry for the identification of cynomolgus monkey and human metabolites of SK & F 101468, a dopamine D2 receptor agonist.	amicloral	187-194	dopamine receptor D2	Homo sapiens	208-228
2543692-1	1989	Growth hormone-releasing peptide (GHRP, SK&F 110679) is a hexapeptide (His-DTrp-Ala-Trp-DPhe-LysNH2) that selectively stimulates the release of growth hormone (GH) but not other pituitary hormones in vitro and in vivo in a variety of animal species.	amicloral	40-46	ghrelin and obestatin prepropeptide	Homo sapiens	0-32
2543692-1	1989	Growth hormone-releasing peptide (GHRP, SK&F 110679) is a hexapeptide (His-DTrp-Ala-Trp-DPhe-LysNH2) that selectively stimulates the release of growth hormone (GH) but not other pituitary hormones in vitro and in vivo in a variety of animal species.	amicloral	40-46	ghrelin and obestatin prepropeptide	Homo sapiens	34-38
2543692-1	1989	Growth hormone-releasing peptide (GHRP, SK&F 110679) is a hexapeptide (His-DTrp-Ala-Trp-DPhe-LysNH2) that selectively stimulates the release of growth hormone (GH) but not other pituitary hormones in vitro and in vivo in a variety of animal species.	amicloral	40-46	growth hormone 1	Homo sapiens	148-162
2559032-7	1989	The 5-lipoxygenase inhibitors, SK&F 86002, SK&F 104493, and phenidone inhibited LTB4 production in vivo as well as inflammatory cell infiltration induced by arachidonic acid.	amicloral	47-53	arachidonate 5-lipoxygenase	Mus musculus	4-18
2678952-2	1989	SK&F 86002, a dual inhibitor of the arachidonate metabolism, has been shown to inhibit LPS induced IL-1 production in human monocytes.	amicloral	0-6	interleukin 1 alpha	Homo sapiens	103-107
2678952-4	1989	The IC50 of SK&F 86002 for the TNF production was 5-8 microM, and greater than 20 microM for the other three cytokines.	amicloral	12-18	tumor necrosis factor	Homo sapiens	35-38
2678952-6	1989	Taken together these data indicate that the inhibitory effect of SK&F 86002 on IL-1 production is selective and the production of cytokines in drug treated monocytes can be differentially affected.	amicloral	65-71	interleukin 1 alpha	Homo sapiens	83-87
2801311-0	1989	Inhibitory effect of SK&F 86002 on monocyte IL-1 production.	amicloral	21-27	interleukin 1 alpha	Homo sapiens	48-52
2801311-2	1989	SK&F 86002-A2 was shown to be a potent inhibitor of IL-1 production with a 50% inhibitory concentration (IC50) of 1.3 +/- 0.5 microM.	amicloral	0-6	interleukin 1 alpha	Homo sapiens	56-60
2801311-6	1989	Thus, SK&F 86002 may serve as a useful reagent in the understanding of the synthetic, processing and/or secretory pathways of interleukin-1, and may provide important insight into the treatment of disease states where aberrant IL-1 production is implicated.	amicloral	6-12	interleukin 1 alpha	Homo sapiens	231-235
2524585-0	1989	Cyclooxygenase inhibition unmasks the full antidiuretic agonist activity of the vasopressin antagonist, SK&F 101926, in dogs.	amicloral	104-110	prostaglandin-endoperoxide synthase 1	Canis lupus familiaris	0-14
2524585-0	1989	Cyclooxygenase inhibition unmasks the full antidiuretic agonist activity of the vasopressin antagonist, SK&F 101926, in dogs.	amicloral	104-110	arginine vasopressin	Rattus norvegicus	80-91
2566992-4	1989	Two mixed DA D1/D2 antagonists (cis(Z)-flupentixol and zuclopenthixol) inhibited the effects of both SK&F 38393 and pergolide on the spinal reflex, while the neuroleptically inactive isomer of clopenthixol (trans(E)-clopenthixol) was also inactive in this context.	amicloral	101-107	defender against cell death 1	Rattus norvegicus	10-15
2522994-2	1989	A new animal model for vasopressin activity has been developed in dogs that duplicates the clinical agonist findings exhibited with SK&F 101926.	amicloral	132-138	arginine vasopressin	Homo sapiens	23-34
2568682-7	1989	The presence of DA1 receptors was confirmed in isolated perfused mesenteric arteries by standard pharmacologic techniques; stimulation by FM resulted in vasodilation which was inhibited by the DA1 receptor antagonist SK&F 83566-C.	amicloral	217-223	RT1 class II, locus Da	Rattus norvegicus	16-19
2492908-8	1989	The administration of SK&F 86002 to P. acnes/LPS-treated mice decreased serum levels of tumor necrosis factor (TNF), which was not observed following naproxen or indomethacin treatment.	amicloral	22-28	tumor necrosis factor	Mus musculus	92-113
2492908-8	1989	The administration of SK&F 86002 to P. acnes/LPS-treated mice decreased serum levels of tumor necrosis factor (TNF), which was not observed following naproxen or indomethacin treatment.	amicloral	22-28	tumor necrosis factor	Mus musculus	115-118
2560662-15	1989	The 5-lipoxygenase/cyclooxygenase inhibitors, SK & F 86002 and BW 775C, also attenuated the endotoxin-induced increase in hematocrit, whereas indomethacin, heparin, daltroban, or the selective V1 vasopressin receptor antagonist [d(CH2)5Tyr(Me)]AVP did not significantly affect the endotoxin-induced hemoconcentration.	amicloral	46-53	arachidonate 5-lipoxygenase	Rattus norvegicus	4-18
2469790-0	1989	SK&F 93574, a histamine H2-receptor antagonist, releases histamine in the dog.	amicloral	0-6	histamine receptor H2	Canis lupus familiaris	18-39
2568682-7	1989	The presence of DA1 receptors was confirmed in isolated perfused mesenteric arteries by standard pharmacologic techniques; stimulation by FM resulted in vasodilation which was inhibited by the DA1 receptor antagonist SK&F 83566-C.	amicloral	217-223	RT1 class II, locus Da	Rattus norvegicus	193-196
3142488-4	1988	Treatment with SK&F 86002, SK&F 104351, phenidone, or dexamethasone significantly reduced disease severity, as judged by clinical score (55%, 72%, 41%, and 45% inhibition, respectively) and SAP levels (62%, 94%, 52%, and 94% inhibition, respectively) in arthritic mice.	amicloral	15-21	amyloid P component, serum	Mus musculus	198-201
3142488-4	1988	Treatment with SK&F 86002, SK&F 104351, phenidone, or dexamethasone significantly reduced disease severity, as judged by clinical score (55%, 72%, 41%, and 45% inhibition, respectively) and SAP levels (62%, 94%, 52%, and 94% inhibition, respectively) in arthritic mice.	amicloral	31-37	amyloid P component, serum	Mus musculus	198-201
3572812-2	1987	SK&F 102698 [1-(3,5-difluorobenzyl)imidazole-2-thiol] is the prototype molecule of this class of substituted 1-benzylimidazole-2-thiols and is one of the most potent inhibitors of DBH yet described.	amicloral	0-6	dopamine beta-hydroxylase	Rattus norvegicus	184-187
2898333-1	1988	The pharmacokinetics of SK&F recombinant two-chain tissue-type plasminogen activator (tPA) following intravenous (iv) infusion were characterized in anesthetized, open chested mongrel dogs in which artificial intracoronary thrombi were formed.	amicloral	24-30	tissue-type plasminogen activator	Canis lupus familiaris	90-93
2828915-9	1988	Lysine vasopressin, the selective V2 agonist dDAVP, and the V1-selective agonist SK&F 105349 were at least 10- to 100-fold less potent than oxytocin and exhibited only partial agonist activity.	amicloral	81-87	oxytocin/neurophysin I prepropeptide	Sus scrofa	144-152
2894879-0	1988	Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist.	amicloral	13-19	histamine receptor H 2	Rattus norvegicus	69-90
3148560-0	1988	Inhibition of monocyte IL-1 production by the anti-inflammatory compound, SK&F 86002.	amicloral	74-80	interleukin 1 alpha	Homo sapiens	23-27
3148560-2	1988	SK&F 86002, a novel dihydroimidazo thiazoline which inhibits both 5-lipoxygenase- and cyclooxygenase-mediated arachidonate metabolism was shown to be a potent inhibitor of IL-1 production by LPS-stimulated human monocytes.	amicloral	0-6	arachidonate 5-lipoxygenase	Homo sapiens	70-84
3148560-2	1988	SK&F 86002, a novel dihydroimidazo thiazoline which inhibits both 5-lipoxygenase- and cyclooxygenase-mediated arachidonate metabolism was shown to be a potent inhibitor of IL-1 production by LPS-stimulated human monocytes.	amicloral	0-6	interleukin 1 alpha	Homo sapiens	176-180
3148560-7	1988	The inhibition of IL-1 production by SK&F 86002 adds another facet of drug action contributing to its spectrum of anti-inflammatory activities.	amicloral	37-43	interleukin 1 alpha	Homo sapiens	18-22
2963185-1	1988	The dopamine D-1 agonist SK&F 38393 (10 mg/kg) the D-2 agonist (-)-NPA (0.04 mg/kg) and d-amphetamine (1.0 mg/kg) were established as discriminative stimuli versus saline in rats.	amicloral	25-31	solute carrier family 3 member 1	Rattus norvegicus	55-58
2522994-3	1989	In this model we have discovered that substitution of a cis-4"-methyl group on the Pmp moiety at residue 1 of vasopressin antagonists results in substantially reduced agonist activity compared to the unsubstituted molecule (SK&F 101926).	amicloral	224-230	arginine vasopressin	Homo sapiens	110-121
3050029-0	1988	Further characterization of the cardiovascular effects of the dopamine beta-hydroxylase inhibitor SK&F 102698 in conscious hypertensive rats.	amicloral	98-104	dopamine beta-hydroxylase	Rattus norvegicus	62-87
3050029-1	1988	The dopamine beta-hydroxylase inhibitor SK&F 102698 was characterized by studying its cardiovascular effects in hypertensive rats.	amicloral	40-46	dopamine beta-hydroxylase	Rattus norvegicus	4-29
3050029-6	1988	The antihypertensive mechanism of action of dopamine beta-hydroxylase inhibition was probed with the selective DA1-receptor antagonist SCH 23390, which produced an attenuation of the antihypertensive effects of SK&F 102698.	amicloral	211-217	dopamine beta-hydroxylase	Rattus norvegicus	44-69
3050029-13	1988	These data indicate that inhibition of dopamine beta-hydroxylase with SK&F 102698 results in both peripherally and centrally mediated cardiovascular effects and suggest that central dopamine receptors contribute to the control of systemic blood pressure in hypertensive models associated with an increased sympathetic outflow.	amicloral	70-76	dopamine beta-hydroxylase	Rattus norvegicus	39-64
3388423-1	1988	The purpose of this study was to determine whether a 30-day administration of SK&F 86002-A2, an inhibitor of cyclooxygenase and 5-lipoxygenase pathways of arachidonate metabolism, adversely affected reproductive cycles, ovarian structure, and/or pituitary/ovarian hormone secretion.	amicloral	78-84	arachidonate 5-lipoxygenase	Rattus norvegicus	132-146
3385645-0	1988	Effects of the novel dopamine beta-hydroxylase inhibitor SK&F 102698 on catecholamines and blood pressure in spontaneously hypertensive rats.	amicloral	57-63	dopamine beta-hydroxylase	Rattus norvegicus	21-46
3385645-1	1988	The novel dopamine beta-hydroxylase (D beta H) inhibitor SK&F 102698 was characterized in vitro with soluble enzyme from bovine adrenal medulla and in vivo by measuring the dopamine/norepinephrine (DA/NE) ratio in the mesenteric artery, heart and brains of spontaneously hypertensive rats (SHR).	amicloral	57-63	dopamine beta-hydroxylase	Bos taurus	10-35
3361442-1	1988	The vasopressin analog desGly(CH2)5D-Tyr(Et)VAVP (SK&F 101926) is a potent antagonist of the antidiuretic action of vasopressin in rats, dogs, and squirrel monkeys, demonstrating minimal agonist activity in these species.	amicloral	50-56	arginine vasopressin	Rattus norvegicus	4-15
3361442-1	1988	The vasopressin analog desGly(CH2)5D-Tyr(Et)VAVP (SK&F 101926) is a potent antagonist of the antidiuretic action of vasopressin in rats, dogs, and squirrel monkeys, demonstrating minimal agonist activity in these species.	amicloral	50-56	arginine vasopressin	Rattus norvegicus	120-131
2837395-9	1988	The ability of SK&F 104353 to block LTD4-induced activation of PKC further suggests that stimulation of PKC might be an important intermediate step in the signal transduction mechanism of the LTD4 receptor in RBL-1 cells.	amicloral	15-21	RB transcriptional corepressor like 1	Rattus norvegicus	213-218
2963816-3	1988	These responses to vasopressin were inhibited by the V1-specific antagonist SK&F 100273, indicating that these were receptor-mediated phenomena.	amicloral	76-82	arginine vasopressin	Rattus norvegicus	19-30
2906470-3	1988	Furthermore, toxicologic problems of unsurmountable and/or or long-acting histamine H2-receptor antagonists (tiotidine, loxtidine, and SK&F 93479) are discussed.	amicloral	135-141	histamine receptor H2	Homo sapiens	74-95
2823821-3	1987	In addition, SK&F 86002 inhibited the generation of dihydroxyeicosatetraenoic acid (diHETE) and 5-hydroxyeicosatetraenoic acid (5-HETE) by a high speed supernatant fraction of RBL-1 cells (IC50 10 microM).	amicloral	13-19	RB transcriptional corepressor like 1	Homo sapiens	180-185
2823821-4	1987	Cellular production of 5-lipoxygenase products was inhibited by SK&F 86002 as measured by leukotriene B4 (LTB4) generation from human neutrophils (IC50 20 microM), leukotriene C4 (LTC4) generation by human monocytes (IC50 20 microM), and 5-HETE production by RBL-1 cells (IC50 40 microM).	amicloral	64-70	arachidonate 5-lipoxygenase	Homo sapiens	23-37
2823821-4	1987	Cellular production of 5-lipoxygenase products was inhibited by SK&F 86002 as measured by leukotriene B4 (LTB4) generation from human neutrophils (IC50 20 microM), leukotriene C4 (LTC4) generation by human monocytes (IC50 20 microM), and 5-HETE production by RBL-1 cells (IC50 40 microM).	amicloral	64-70	RB transcriptional corepressor like 1	Homo sapiens	263-268
3039684-2	1987	SK&F 88046 inhibited platelet aggregation and secretion induced by AA, U46619, EP171 and thrombin at low (0.05 U/ml) but not at a high (1 U/ml) concentrations.	amicloral	0-6	coagulation factor II, thrombin	Homo sapiens	93-101
3572812-7	1987	SK&F 102698 inhibited DBH in vivo as demonstrated by its ability to increase vascular levels of dopamine (DA) while concomitantly decreasing vascular levels of norepinephrine (NE), thus increasing the overall DA/NE ratio.	amicloral	0-6	dopamine beta-hydroxylase	Rattus norvegicus	26-29
2882972-8	1987	These studies indicate that the omega- and (omega-1)-hydroxylations of SK&F 102,081 are probably carried out by different isozymes of hepatic cytochrome P-450 in the rat.	amicloral	71-77	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	146-162
2963185-13	1988	It is concluded that the cues induced by SK&F 38393 and (-)-NPA are mediated by separate D-1 and D-2 sites, whereas both sites contribute to the effect of d-amphetamine.	amicloral	41-47	solute carrier family 3 member 1	Rattus norvegicus	101-104
2951585-2	1987	We chose to radiolabel SK&F 101926 because this vasopressin analog is a potent antagonist of vascular V1 and renal V2 vasopressin receptors in all species studied.	amicloral	23-29	arginine vasopressin	Rattus norvegicus	52-63
2886338-1	1987	Temelastine (SK&F 93944) is a novel histamine H1-receptor antagonist with a high degree of protein binding and predominant hepatic elimination.	amicloral	13-19	histamine receptor H1	Homo sapiens	40-61
2949991-6	1987	The maximal effects of SK & F 38393 plus quinpirole were effectively blocked by either a D-1 antagonist (SCH 23390) or a D-2 antagonist (YM 09151-2) confirming the close relation between D-1 and D-2 receptor sites in the brain.	amicloral	23-30	solute carrier family 3 member 1	Rattus norvegicus	125-128
2949991-6	1987	The maximal effects of SK & F 38393 plus quinpirole were effectively blocked by either a D-1 antagonist (SCH 23390) or a D-2 antagonist (YM 09151-2) confirming the close relation between D-1 and D-2 receptor sites in the brain.	amicloral	23-30	solute carrier family 3 member 1	Rattus norvegicus	199-202
2887313-2	1987	Fenoldopam (SK&F 82526) is a potent agonist at DA1 receptors, with much less agonist activity at the DA2 subtype or at alpha and beta adrenoceptors.	amicloral	12-18	RT1 class II, locus Da	Rattus norvegicus	51-54
2887313-4	1987	SK&F 85174, the N-allyl derivative of fenoldopam, retains potent DA1 agonist activity but also has moderately potent agonist activity at the DA2 receptor.	amicloral	0-6	RT1 class II, locus Da	Rattus norvegicus	69-72
2875234-9	1986	Thus, SK&F 93944 is a highly potent, selective histamine H1-receptor antagonist which is efficacious vs. pharmacologic and antigen-induced bronchoconstriction.	amicloral	6-12	histamine receptor H1	Canis lupus familiaris	51-72
3490631-0	1986	Stereotyped behaviour in response to the selective D-2 dopamine receptor agonist RU 24213 is enhanced by pretreatment with the selective D-1 agonist SK&F 38393.	amicloral	149-155	dopamine receptor D2	Homo sapiens	51-72
2879585-10	1986	SK&F 93944 may have an advantage over classical histamine H1-receptor antagonists in that it is likely to be devoid of untoward effects on the central nervous system.	amicloral	0-6	histamine H1 receptor	Cavia porcellus	52-73
2873965-3	1986	This stimulation was blocked by the selective DA1 receptor antagonist SK&F 83566, but not by the beta-receptor antagonist propranolol.	amicloral	70-76	immunoglobulin heavy diversity 4-11 (non-functional)	Homo sapiens	46-49
3594004-3	1986	When SK&F 64 139 was administered (40 mg/kg, ip) to male rats or to female rats during diestrus or proestrus, plasma prolactin levels were not different from those of control groups.	amicloral	5-11	prolactin	Rattus norvegicus	121-130
3594004-4	1986	Lactating and ovariectomized rats, however, responded to the same SK&F 64 139 dose with an increase in plasma prolactin levels: 210.02 +/- 22.72 vs 378.66 +/- 42.57 (mean +/- SEM) for control of lactating rats, and 4.35 +/- 0.52 vs 6.21 +/- 0.60 ng/ml for control ovariectomized rat.	amicloral	66-72	prolactin	Rattus norvegicus	114-123
2434770-5	1986	A selective vasopressin pressor (V1) antagonist (SK&F 100273) was inactive as a diuretic agent in these tests.	amicloral	49-55	arginine vasopressin	Rattus norvegicus	12-23
2434770-6	1986	SK&F 101926 antagonized, in a competitive fashion, exogenous vasopressin-stimulated antidiuresis in conscious water-loaded rats.	amicloral	0-6	arginine vasopressin	Rattus norvegicus	65-76
6352246-7	1983	However, selective EPI synthesis inhibition with SK&F 64139 only partially prevented this increase in LHRH.	amicloral	49-55	gonadotropin releasing hormone 1	Rattus norvegicus	106-110
6152747-0	1984	Pathology of the forestomach in rats treated for 1 year with a new histamine H2-receptor antagonist, SK&F 93479 trihydrochloride.	amicloral	101-107	histamine receptor H 2	Rattus norvegicus	67-88
2860689-0	1985	Differential involvement of dopamine D-1 and D-2 receptors in the circling behaviour induced by apomorphine, SK & F 38393, pergolide and LY 171555 in 6-hydroxydopamine-lesioned rats.	amicloral	109-116	solute carrier family 3 member 1	Rattus norvegicus	0-48
6151803-5	1984	These findings suggest that SK&F 93479 lacks non-specific antiarrhythmic activity and that its protective effects against coronary artery ligation may be mediated by its histamine H2-receptor antagonizing action.	amicloral	28-34	histamine receptor H 2	Rattus norvegicus	174-195
6147403-2	1984	Two centrally active PNMT inhibitors (SK&F 64139 and LY134046) were administered over a 6-day treatment period to cause prolonged reductions in epinephrine formation.	amicloral	38-44	phenylethanolamine N-methyltransferase	Homo sapiens	21-25
6144180-0	1984	Repeated pentagastrin-stimulated gastric acid secretory tests carried out in the evaluation of the pharmacodynamics of a new histamine H2-receptor antagonist, SK&F 93479.	amicloral	159-165	histamine receptor H2	Homo sapiens	125-146
6144180-1	1984	Single doses of 10 mg or 20 mg intravenously or 25 mg or 40 mg orally of a new histamine H2-receptor antagonist, SK&F 93479, have been administered to 31 patients with peptic ulcer disease.	amicloral	113-119	histamine receptor H2	Homo sapiens	79-100
6195482-5	1983	Although SK&F 64139 is a potent inhibitor of phenylethanolamine N-methyltransferase (PNMT), the time course of blood pressure reduction is not consistent with PNMT inhibition as a mechanism for its antihypertensive action.	amicloral	9-15	phenylethanolamine-N-methyltransferase	Rattus norvegicus	49-87
6195482-5	1983	Although SK&F 64139 is a potent inhibitor of phenylethanolamine N-methyltransferase (PNMT), the time course of blood pressure reduction is not consistent with PNMT inhibition as a mechanism for its antihypertensive action.	amicloral	9-15	phenylethanolamine-N-methyltransferase	Rattus norvegicus	89-93
6132343-11	1982	In pithed rats the pressor responses to both methoxamine and clonidine were antagonized by SK & F 64139 suggesting blockade of vascular alpha 1-and alpha 2-adrenoceptors by the PNMT inhibitor.	amicloral	91-98	phenylethanolamine-N-methyltransferase	Rattus norvegicus	181-185
6838886-4	1983	Phenylethanolamine-N-methyltransferase inhibitors S-adenosyl-homocysteine and SK & F 64139 can block this photoactivated cross-linkage.	amicloral	78-85	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
6752375-9	1982	RNa rats treated with SK&F 64139 were found to have decreased phenylethanolamine N-methyltransferase activity by an average 80% in selected brain stem nuclei when compared with nontreated rats.	amicloral	22-28	phenylethanolamine-N-methyltransferase	Rattus norvegicus	66-104
6223952-0	1982	Short-term toxicological studies with impromidine (SK&F 92676): a specific histamine H2-receptor agonist.	amicloral	51-57	histamine receptor H2	Canis lupus familiaris	79-100
6125896-1	1982	SK&F 29661 (1,2,3,4-tetrahydro-7-isoquinoline-sulfonamide) is a potent and selective in vitro and in vivo inhibitor of adrenal phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28).	amicloral	0-6	phenylethanolamine-N-methyltransferase	Rattus norvegicus	131-169
6125896-1	1982	SK&F 29661 (1,2,3,4-tetrahydro-7-isoquinoline-sulfonamide) is a potent and selective in vitro and in vivo inhibitor of adrenal phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28).	amicloral	0-6	phenylethanolamine-N-methyltransferase	Rattus norvegicus	171-175
7202481-1	1980	After 7 day dosing with SK & F 64139, an inhibitor of adrenal and CNS PNMT, a stoichiometric relationship is observed between epinephrine decrease and norepinephrine increase in adrenal tissue.	amicloral	24-31	phenylethanolamine-N-methyltransferase	Rattus norvegicus	74-78
7252985-3	1981	7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (SK&F 64139) is a potent inhibitor of phenylethanolamine N-methyltransferase (IC50 = 10 muM) that may have therapeutic utility in man.	amicloral	45-51	phenylethanolamine N-methyltransferase	Homo sapiens	86-124
7252985-3	1981	7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (SK&F 64139) is a potent inhibitor of phenylethanolamine N-methyltransferase (IC50 = 10 muM) that may have therapeutic utility in man.	amicloral	45-51	latexin	Homo sapiens	136-139
6119751-2	1981	The parent compound, SK&F 64139, inhibits PNMT in the nanomolar range and also has moderate affinity as an alpha 2-adrenoceptor antagonist.	amicloral	21-27	phenylethanolamine N-methyltransferase	Homo sapiens	46-50
6119751-6	1981	It was also possible to substantially enhance the PNMT inhibitory activity of a highly polar compound (SK&UF 29661) without decreasing its receptor specificity, although the resulting analogue contains an additional lipophilic chloro substituent and does, unlike SK&F 29661, penetrate into the CNS.	amicloral	103-109	phenylethanolamine N-methyltransferase	Homo sapiens	50-54
6108034-1	1980	We have compared the effects of cimetidine and SK&F 92994, a new more potent histamine H2 receptor antagonist, on serum prolactin, and also assessed the effect of the H2 receptor agonist impromidine on the response to cimetidine.	amicloral	47-53	prolactin	Homo sapiens	124-133
6109637-0	1980	The blockade of alpha 2-adrenoceptors by the PNMT inhibitaor SK&F 64139.	amicloral	61-67	phenylethanolamine-N-methyltransferase	Rattus norvegicus	45-49
7432557-3	1980	The former but not the latter enzyme is markedly inhibited by micromolar concentrations of the PNMT antagonist, SK & F 64139.	amicloral	112-119	phenylethanolamine N-methyltransferase	Homo sapiens	95-99
445951-1	1979	DCTQ (SK&F 64139) is a potent inhibitor of both adrenal and central nervous system (CNS) phenylethanolamine N-methyltransferase (PNMT).	amicloral	6-12	phenylethanolamine N-methyltransferase	Homo sapiens	93-131
445951-1	1979	DCTQ (SK&F 64139) is a potent inhibitor of both adrenal and central nervous system (CNS) phenylethanolamine N-methyltransferase (PNMT).	amicloral	6-12	phenylethanolamine N-methyltransferase	Homo sapiens	133-137
444372-0	1979	Impromidine (SK&F 92676)--a potent and highly selective histamine H2-receptor agonist in man [proceedings].	amicloral	13-19	histamine receptor H2	Homo sapiens	60-81
215747-0	1979	Studies on SK&F 29661, an organ-specific inhibitor of phenylethanolamine N-methyltransferase.	amicloral	11-17	phenylethanolamine-N-methyltransferase	Rattus norvegicus	58-96
683413-7	1978	Kinetic studies showed that the type of inhibition of PNMT from rat brain and rat adrenals by SK&F 7698 was the same as described for PNMT from rabbit adrenals.	amicloral	94-100	phenylethanolamine-N-methyltransferase	Rattus norvegicus	54-58
683413-7	1978	Kinetic studies showed that the type of inhibition of PNMT from rat brain and rat adrenals by SK&F 7698 was the same as described for PNMT from rabbit adrenals.	amicloral	94-100	phenylethanolamine-N-methyltransferase	Rattus norvegicus	138-142
7202481-3	1980	SK & F 64139 was found to possess significant adrenal MAO inhibitory activity, but SK & F 29661 does not.	amicloral	0-7	monoamine oxidase A	Rattus norvegicus	58-61
7408955-2	1980	The bradycardia, which is abolished by vagotomy and partially antagonized by atropine, was significantly prolonged by pretreatment with SK&F 64139, a potent in vivo inhibitor of peripheral and central (CNS) phenylethanolamine N-methyltransferase (PNMT).	amicloral	136-142	phenylethanolamine-N-methyltransferase	Rattus norvegicus	211-249
7408955-2	1980	The bradycardia, which is abolished by vagotomy and partially antagonized by atropine, was significantly prolonged by pretreatment with SK&F 64139, a potent in vivo inhibitor of peripheral and central (CNS) phenylethanolamine N-methyltransferase (PNMT).	amicloral	136-142	phenylethanolamine-N-methyltransferase	Rattus norvegicus	251-255
7408955-4	1980	These data suggest that the effects of SK&F 64139 are a result of inhibition of central PNMT and that epinephrine may function as a central neurotransmitter mediating cardiovascular responses to hemorrhage, at least under the conditions of these studies.	amicloral	39-45	phenylethanolamine-N-methyltransferase	Rattus norvegicus	92-96
6153165-0	1980	Gastric secretory studies in humans with impromidine (SK&F 92676)--a specific histamine H2 receptor agonist.	amicloral	54-60	histamine receptor H2	Homo sapiens	82-103
406652-0	1977	The effect of phenylethanolamine n-methyltransferase concentration and species difference on the inhibitory potency of SK&F 64139.	amicloral	119-125	phenylethanolamine N-methyltransferase	Homo sapiens	14-52
406652-1	1977	We have found that the potency of SK&F 64139 in inhibiting rabbit adrenal phenylethanolamine N-methyltransferase (PNMT) is a function of protein concentration when high concentrations of the latter are employed.	amicloral	34-40	phenylethanolamine N-methyltransferase	Oryctolagus cuniculus	78-116
406652-1	1977	We have found that the potency of SK&F 64139 in inhibiting rabbit adrenal phenylethanolamine N-methyltransferase (PNMT) is a function of protein concentration when high concentrations of the latter are employed.	amicloral	34-40	phenylethanolamine N-methyltransferase	Oryctolagus cuniculus	118-122
406652-5	1977	These data provide evidence that the PNMT receptor sites for SK&F 64139 do not differ substantially from species to species and suggest the general utility of this drug as an inhibitor of adrenal epinephrine biosynthesis.	amicloral	61-67	phenylethanolamine N-methyltransferase	Homo sapiens	37-41
876399-1	1977	SK&F 64139, an inhibitor of adrenal phenylethanolamine N-methyltransferase (PNMT), was found to significantly decrease 2-deoxy-D-glucose (2-DG) induced epinephrine excretion in the conscious rat under conditions where the former agent was administered chromically at 50 and 200 mg/kg/day over a 12-day period and 2-DG was administered after 3, 7 and 11 days of treatment.	amicloral	0-6	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-78
876399-1	1977	SK&F 64139, an inhibitor of adrenal phenylethanolamine N-methyltransferase (PNMT), was found to significantly decrease 2-deoxy-D-glucose (2-DG) induced epinephrine excretion in the conscious rat under conditions where the former agent was administered chromically at 50 and 200 mg/kg/day over a 12-day period and 2-DG was administered after 3, 7 and 11 days of treatment.	amicloral	0-6	phenylethanolamine-N-methyltransferase	Rattus norvegicus	80-84
590238-8	1977	A potent and selective competitive inhibitor, SK&F 64139, when added to tissue cultures, prevented increase of PNMT activity by prolonged stimulation.	amicloral	46-52	phenylethanolamine-N-methyltransferase	Rattus norvegicus	115-119
1047087-3	1976	Cefamandole and SK&F 59962 were highly active against both large and small inocula of staphylococci and were resistant to staphylococcal beta-lactamase.	amicloral	16-22	beta-lactamase	Staphylococcus aureus	141-155
825786-1	1976	Chronic administration of SK&F 64139, an inhibitor of phenylethanolamine N-methyltransferase (PNMT), initially resulted in a lowered adrenal epinephrine content in both the rat and squirrel monkey adrenal gland.	amicloral	26-32	phenylethanolamine-N-methyltransferase	Rattus norvegicus	58-96
825786-1	1976	Chronic administration of SK&F 64139, an inhibitor of phenylethanolamine N-methyltransferase (PNMT), initially resulted in a lowered adrenal epinephrine content in both the rat and squirrel monkey adrenal gland.	amicloral	26-32	phenylethanolamine-N-methyltransferase	Rattus norvegicus	98-102
6786-1	1976	SK&F 64139 is a potent, reversible inhibitor of phenylethanolamine N-methyltransferase; its IC50 concentration in our standard assay system was 1 X 10(-7) M. Kinetically, the compound is a competitive inhibitor with respect to norepinephrine but is uncompetitive when S-adenosylmethionine is the variable substrate.	amicloral	0-6	phenylethanolamine-N-methyltransferase	Rattus norvegicus	52-90