PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
15187228-6	2004	The resulting mutant BsTrpRS-mutRNA(UCA)(Trp) pair allows the efficient and selective incorporation of 5-hydroxy-l-tryptophan into mammalian proteins in response to the codon, TGA.	5-Hydroxytryptophan	103-125	T-box transcription factor 1	Homo sapiens	176-179
15037515-6	2004	In both behavioural (potentiation of 5-hydroxytryptophan (5-HTP)-induced behaviour) and electrophysiological studies (inhibition of 5-HT-elicited ion currents in Xenopus oocytes expressing the human SERT (hSERT) R-citalopram inhibited the effects of S-citalopram in a dose-dependent manner.	5-Hydroxytryptophan	58-63	solute carrier family 6 member 4	Homo sapiens	199-203
15260907-2	2004	In the current study, we investigated the acute effects of 5-HT precursor l-5-hydroxytryptophan (5-HTP) on the response to panicogenic challenge with cholecystokinin-tetrapeptide (CCK-4) in healthy volunteers.	5-Hydroxytryptophan	74-95	protein tyrosine kinase 7 (inactive)	Homo sapiens	180-185
15260907-2	2004	In the current study, we investigated the acute effects of 5-HT precursor l-5-hydroxytryptophan (5-HTP) on the response to panicogenic challenge with cholecystokinin-tetrapeptide (CCK-4) in healthy volunteers.	5-Hydroxytryptophan	97-102	protein tyrosine kinase 7 (inactive)	Homo sapiens	180-185
15037515-6	2004	In both behavioural (potentiation of 5-hydroxytryptophan (5-HTP)-induced behaviour) and electrophysiological studies (inhibition of 5-HT-elicited ion currents in Xenopus oocytes expressing the human SERT (hSERT) R-citalopram inhibited the effects of S-citalopram in a dose-dependent manner.	5-Hydroxytryptophan	37-56	solute carrier family 6 member 4	Homo sapiens	199-203
14996410-4	2004	imipramine and venlafaxine (at the higher concentration), 5-HTP (at lower and higher concentrations) and a combination of 5-HTP and fluoxetine (both at the lower concentration) increased the production of IL-6; (2).	5-Hydroxytryptophan	58-63	interleukin 6	Homo sapiens	205-209
14996410-4	2004	imipramine and venlafaxine (at the higher concentration), 5-HTP (at lower and higher concentrations) and a combination of 5-HTP and fluoxetine (both at the lower concentration) increased the production of IL-6; (2).	5-Hydroxytryptophan	122-127	interleukin 6	Homo sapiens	205-209
14519961-0	2003	Effects of insulin and adrenalectomy on elevation of serum leptin levels induced by 5-hydroxytryptophan in mice.	5-Hydroxytryptophan	84-103	leptin	Mus musculus	59-65
14519961-1	2003	We previously reported that a serotonin precursor 5-hydroxytryptophan (5-HTP) increases serum leptin levels in mice.	5-Hydroxytryptophan	50-69	leptin	Mus musculus	94-100
14519961-1	2003	We previously reported that a serotonin precursor 5-hydroxytryptophan (5-HTP) increases serum leptin levels in mice.	5-Hydroxytryptophan	71-76	leptin	Mus musculus	94-100
12941435-2	2003	5-HTP elicited apparent increases in serum leptin levels of mice.	5-Hydroxytryptophan	0-5	leptin	Mus musculus	43-49
12892655-10	2003	Six hours after 5-HTP injection, IL-1beta mRNA increased in the hypothalamus.	5-Hydroxytryptophan	16-21	interleukin 1 beta	Rattus norvegicus	33-41
12941435-8	2003	These results suggest that hyperinsulinemia participates the elevation of serum leptin levels elicited by 5-HTP.	5-Hydroxytryptophan	106-111	leptin	Mus musculus	80-86
12972322-0	2003	Systemic 5-hydroxy-L-tryptophan down-regulates the arcuate CART mRNA level in rats.	5-Hydroxytryptophan	9-31	CART prepropeptide	Rattus norvegicus	59-63
11694540-2	2002	We produced a recombinant full-length chicken alpha-tropomyosin containing a 5-hydroxytryptophan residue at position 269 (formerly an alanine), 15 residues from the C terminus, and show that its fluorescence intensity specifically reports tropomyosin head-to-tail interactions.	5-Hydroxytryptophan	77-96	tropomyosin 1	Gallus gallus	46-63
12920190-6	2003	Tyrosine and the serotonin-precursor 5-hydroxytryptophan also activate AHR signaling in combination with aspartate aminotransferase, suggesting that 4-hydroxyphenylpyruvate and 5-hydroxyindolepyruvate also act as proagonists of AHR.	5-Hydroxytryptophan	37-56	aryl-hydrocarbon receptor	Mus musculus	71-74
12920190-6	2003	Tyrosine and the serotonin-precursor 5-hydroxytryptophan also activate AHR signaling in combination with aspartate aminotransferase, suggesting that 4-hydroxyphenylpyruvate and 5-hydroxyindolepyruvate also act as proagonists of AHR.	5-Hydroxytryptophan	37-56	aryl-hydrocarbon receptor	Mus musculus	228-231
12716407-3	2003	The 5-HT precursor, 5-hydroxytryptophan, injected in combination with the 5-HT reuptake inhibitor, fluoxetine, increased oxytocin mRNA expression in the PVN, and the concentration of vasopressin and oxytocin in plasma, whereas mRNA in the SON was not affected.	5-Hydroxytryptophan	20-39	arginine vasopressin	Rattus norvegicus	183-194
12716407-10	2003	We conclude that stimulation with 5-hydroxytryptophan or 5-HT agonists increases mRNA expression of oxytocin in the PVN and the SON via stimulation of at least 5-HT1A, 5-HT1B, 5-HT2A and 5-HT2C receptors.	5-Hydroxytryptophan	34-53	5-hydroxytryptamine receptor 1A	Rattus norvegicus	160-166
12716407-10	2003	We conclude that stimulation with 5-hydroxytryptophan or 5-HT agonists increases mRNA expression of oxytocin in the PVN and the SON via stimulation of at least 5-HT1A, 5-HT1B, 5-HT2A and 5-HT2C receptors.	5-Hydroxytryptophan	34-53	5-hydroxytryptamine receptor 1B	Rattus norvegicus	168-174
12716407-10	2003	We conclude that stimulation with 5-hydroxytryptophan or 5-HT agonists increases mRNA expression of oxytocin in the PVN and the SON via stimulation of at least 5-HT1A, 5-HT1B, 5-HT2A and 5-HT2C receptors.	5-Hydroxytryptophan	34-53	5-hydroxytryptamine receptor 2A	Rattus norvegicus	176-182
12372003-4	2002	Increased neuronal 5-HT content induced by systemic administration of the precursor 5-hydroxytryptophan (5-HTP) in combination with the 5-HT reuptake inhibitor fluoxetine raised CRH mRNA expression in the paraventricular nucleus (PVN) by 64%, increased pro-opiomelanocortin (POMC) mRNA in the anterior pituitary lobe by 17% and stimulated ACTH secretion five-fold.	5-Hydroxytryptophan	84-103	corticotropin releasing hormone	Rattus norvegicus	178-181
12372003-4	2002	Increased neuronal 5-HT content induced by systemic administration of the precursor 5-hydroxytryptophan (5-HTP) in combination with the 5-HT reuptake inhibitor fluoxetine raised CRH mRNA expression in the paraventricular nucleus (PVN) by 64%, increased pro-opiomelanocortin (POMC) mRNA in the anterior pituitary lobe by 17% and stimulated ACTH secretion five-fold.	5-Hydroxytryptophan	84-103	proopiomelanocortin	Rattus norvegicus	253-273
12372003-4	2002	Increased neuronal 5-HT content induced by systemic administration of the precursor 5-hydroxytryptophan (5-HTP) in combination with the 5-HT reuptake inhibitor fluoxetine raised CRH mRNA expression in the paraventricular nucleus (PVN) by 64%, increased pro-opiomelanocortin (POMC) mRNA in the anterior pituitary lobe by 17% and stimulated ACTH secretion five-fold.	5-Hydroxytryptophan	84-103	proopiomelanocortin	Rattus norvegicus	275-279
12372003-4	2002	Increased neuronal 5-HT content induced by systemic administration of the precursor 5-hydroxytryptophan (5-HTP) in combination with the 5-HT reuptake inhibitor fluoxetine raised CRH mRNA expression in the paraventricular nucleus (PVN) by 64%, increased pro-opiomelanocortin (POMC) mRNA in the anterior pituitary lobe by 17% and stimulated ACTH secretion five-fold.	5-Hydroxytryptophan	105-110	corticotropin releasing hormone	Rattus norvegicus	178-181
12372003-4	2002	Increased neuronal 5-HT content induced by systemic administration of the precursor 5-hydroxytryptophan (5-HTP) in combination with the 5-HT reuptake inhibitor fluoxetine raised CRH mRNA expression in the paraventricular nucleus (PVN) by 64%, increased pro-opiomelanocortin (POMC) mRNA in the anterior pituitary lobe by 17% and stimulated ACTH secretion five-fold.	5-Hydroxytryptophan	105-110	proopiomelanocortin	Rattus norvegicus	253-273
12372003-4	2002	Increased neuronal 5-HT content induced by systemic administration of the precursor 5-hydroxytryptophan (5-HTP) in combination with the 5-HT reuptake inhibitor fluoxetine raised CRH mRNA expression in the paraventricular nucleus (PVN) by 64%, increased pro-opiomelanocortin (POMC) mRNA in the anterior pituitary lobe by 17% and stimulated ACTH secretion five-fold.	5-Hydroxytryptophan	105-110	proopiomelanocortin	Rattus norvegicus	275-279
12372003-6	2002	Systemic administration of a specific anti-CRH antiserum inhibited the ACTH response to 5-HTP and fluoxetine and prevented the 5-HTP and fluoxetine-induced POMC mRNA response in the anterior pituitary lobe.	5-Hydroxytryptophan	88-93	corticotropin releasing hormone	Rattus norvegicus	43-46
12372003-6	2002	Systemic administration of a specific anti-CRH antiserum inhibited the ACTH response to 5-HTP and fluoxetine and prevented the 5-HTP and fluoxetine-induced POMC mRNA response in the anterior pituitary lobe.	5-Hydroxytryptophan	127-132	corticotropin releasing hormone	Rattus norvegicus	43-46
14527871-7	2003	RESULTS: Treatment with 5-HTP significantly delayed hindlimb weakness and mortality in SOD1 G93A mice in a dose-dependent manner.	5-Hydroxytryptophan	24-29	superoxide dismutase 1, soluble	Mus musculus	87-91
14527871-11	2003	CONCLUSIONS: Increased blood serotonin by administration of 5-HTP in SOD1 G93A mice led to improved locomotor function and survival.	5-Hydroxytryptophan	60-65	superoxide dismutase 1, soluble	Mus musculus	69-73
14501158-4	2003	The compound was as effective as SERT inhibitors such as fluoxetine and fluvoxamine in a 5-hydroxytryptophan-enhancing test in mice.	5-Hydroxytryptophan	89-108	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	33-37
12939046-1	2003	The intertidal sponge Hymeniacidon heliophila which survives under intense sunlight contains the antioxidant amino acid L-5-hydroxytryptophan (L-5-HTP) as major constituent.	5-Hydroxytryptophan	120-141	ribosomal protein L5	Homo sapiens	143-150
12686106-1	2003	Dopa decarboxylase (DDC) catalyzes as main reaction the stereospecific CO(2) abstraction from L-Dopa and L-5-hydroxytryptophan (5-HTP), generating the corresponding aromatic amines, dopamine and serotonin, respectively.	5-Hydroxytryptophan	105-126	dopa decarboxylase	Sus scrofa	0-18
12686106-1	2003	Dopa decarboxylase (DDC) catalyzes as main reaction the stereospecific CO(2) abstraction from L-Dopa and L-5-hydroxytryptophan (5-HTP), generating the corresponding aromatic amines, dopamine and serotonin, respectively.	5-Hydroxytryptophan	128-133	dopa decarboxylase	Sus scrofa	0-18
12588512-1	2003	Serotonin (5-HT), 5-HT agonists, the 5-HT precursor 5-hydroxytryptophan, 5-HT-releasers and -reuptake inhibitors stimulate the release of vasopressin and oxytocin.	5-Hydroxytryptophan	52-71	arginine vasopressin	Homo sapiens	138-149
12588512-1	2003	Serotonin (5-HT), 5-HT agonists, the 5-HT precursor 5-hydroxytryptophan, 5-HT-releasers and -reuptake inhibitors stimulate the release of vasopressin and oxytocin.	5-Hydroxytryptophan	52-71	oxytocin/neurophysin I prepropeptide	Homo sapiens	154-162
15206795-6	2003	We observed that both enzymes converted this substrate to melanin and that peroxidase, in the presence of hydrogen peroxide, was much more effective than tyrosinase in catalysing the oxidative polymerization of 5-hydroxytryptophan, with the formation of insoluble black melanin-like pigments.	5-Hydroxytryptophan	211-230	tyrosinase	Homo sapiens	154-164
12057843-1	2002	The in vivo sensitivity of presynaptic 5-HT(1A) receptors (autoreceptors and heteroreceptors) modulating the synthesis of 5-hydroxytryptophan/serotonin (5-HTP/5-HT) and 3,4-dihydroxyphenylalanine/dopamine (DOPA/DA) in rat brain was investigated after ethanol treatment and withdrawal.	5-Hydroxytryptophan	122-141	5-hydroxytryptamine receptor 1A	Rattus norvegicus	39-46
12057843-1	2002	The in vivo sensitivity of presynaptic 5-HT(1A) receptors (autoreceptors and heteroreceptors) modulating the synthesis of 5-hydroxytryptophan/serotonin (5-HTP/5-HT) and 3,4-dihydroxyphenylalanine/dopamine (DOPA/DA) in rat brain was investigated after ethanol treatment and withdrawal.	5-Hydroxytryptophan	153-158	5-hydroxytryptamine receptor 1A	Rattus norvegicus	39-46
12200739-7	2002	The AADC enzyme substrates L-dopa and 5-hydroxytryptophan (5-HTP) were elevated in CSF.	5-Hydroxytryptophan	38-57	dopa decarboxylase	Homo sapiens	4-8
12200739-7	2002	The AADC enzyme substrates L-dopa and 5-hydroxytryptophan (5-HTP) were elevated in CSF.	5-Hydroxytryptophan	38-57	colony stimulating factor 2	Homo sapiens	83-86
12200739-7	2002	The AADC enzyme substrates L-dopa and 5-hydroxytryptophan (5-HTP) were elevated in CSF.	5-Hydroxytryptophan	59-64	dopa decarboxylase	Homo sapiens	4-8
12200739-7	2002	The AADC enzyme substrates L-dopa and 5-hydroxytryptophan (5-HTP) were elevated in CSF.	5-Hydroxytryptophan	59-64	colony stimulating factor 2	Homo sapiens	83-86
12269391-3	2002	injection of nantenine (13.3, 20 and 30 mg/kg) as well as the 5-HT2A receptor antagonist ketanserin (0.0625, 0.25 and 1 mg/kg) inhibited the 5-hydroxy-L-tryptophan (l-5-HTP; 75 mg/kg, i.p.)	5-Hydroxytryptophan	165-172	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	62-77
12269391-10	2002	These results suggest that nantenine inhibits l-5-HTP plus clorgyline-induced head- twitch response by blocking 5-HT2A receptors in the central nervous system.	5-Hydroxytryptophan	46-53	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	112-118
11823896-4	2002	Brain 5-HT function was assessed by measuring the corticosterone/cortisol response to the 5-HT precursor, 5-hydroxytryptophan (5-HTP), a response believed to be mediated via indirect activation of 5-HT(2A) receptors.	5-Hydroxytryptophan	106-125	POU class 6 homeobox 1	Homo sapiens	0-7
11823896-4	2002	Brain 5-HT function was assessed by measuring the corticosterone/cortisol response to the 5-HT precursor, 5-hydroxytryptophan (5-HTP), a response believed to be mediated via indirect activation of 5-HT(2A) receptors.	5-Hydroxytryptophan	127-132	POU class 6 homeobox 1	Homo sapiens	0-7
10221360-1	1999	The study was undertaken to assess the long term effects of tryptophan (TRP) depletion through diet on the prolactin (PRL) responses to the serotonin (5-hydroxytryptophan, 5-HT) agonists m-chlorophenyl-piperazine (mCPP) and 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in the male rat.	5-Hydroxytryptophan	151-170	prolactin	Rattus norvegicus	107-116
11685243-1	2001	DOPA decarboxylase (DDC) is responsible for the synthesis of the key neurotransmitters dopamine and serotonin via decarboxylation of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan, respectively.	5-Hydroxytryptophan	175-196	dopa decarboxylase	Homo sapiens	0-18
11685243-1	2001	DOPA decarboxylase (DDC) is responsible for the synthesis of the key neurotransmitters dopamine and serotonin via decarboxylation of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan, respectively.	5-Hydroxytryptophan	175-196	dopa decarboxylase	Homo sapiens	20-23
11443526-1	2001	Dopa decarboxylase (DDC) is an enzyme which catalyses the decarboxylation of both dopa to dopamine and L-5 hydroxytryptophan to serotonin.	5-Hydroxytryptophan	103-124	dopa decarboxylase	Homo sapiens	0-18
11443526-1	2001	Dopa decarboxylase (DDC) is an enzyme which catalyses the decarboxylation of both dopa to dopamine and L-5 hydroxytryptophan to serotonin.	5-Hydroxytryptophan	103-124	dopa decarboxylase	Homo sapiens	20-23
11270917-2	2001	This study was carried out to examine the effects of antidepressive agents, i.e., imipramine, venlafaxine, L-5-hydroxytryptophan, and fluoxetine on the production of interferon-gamma (IFN-gamma), a proinflammatory cytokine, and interleukin-10 (IL-10), a negative immunoregulatory cytokine.	5-Hydroxytryptophan	107-128	interferon gamma	Homo sapiens	166-182
11270917-2	2001	This study was carried out to examine the effects of antidepressive agents, i.e., imipramine, venlafaxine, L-5-hydroxytryptophan, and fluoxetine on the production of interferon-gamma (IFN-gamma), a proinflammatory cytokine, and interleukin-10 (IL-10), a negative immunoregulatory cytokine.	5-Hydroxytryptophan	107-128	interferon gamma	Homo sapiens	184-193
11106878-3	2001	We show that pharmacological agents that increase brain 5-HT levels (fluoxetine or 5-hydoxytryptophan, 5-HTP) abolish the preference of chronically morphine-treated, withdrawn rats for a morphine-associated environment.	5-Hydroxytryptophan	103-108	POU class 6 homeobox 1	Rattus norvegicus	50-57
10980257-7	2000	Synthesis of 5-HT, estimated by the measurement of the accumulation of 5-hydroxytryptophan (5-HTP) ex vivo or in vitro, is modulated by the 5-HT(1B) autoreceptors.	5-Hydroxytryptophan	71-90	5-hydroxytryptamine receptor 1B	Homo sapiens	140-147
10980257-7	2000	Synthesis of 5-HT, estimated by the measurement of the accumulation of 5-hydroxytryptophan (5-HTP) ex vivo or in vitro, is modulated by the 5-HT(1B) autoreceptors.	5-Hydroxytryptophan	92-97	5-hydroxytryptamine receptor 1B	Homo sapiens	140-147
10899627-0	2000	Domain-specific spectroscopy of 5-hydroxytryptophan-containing variants of Escherichia coli DnaJ.	5-Hydroxytryptophan	32-51	DnaJ	Escherichia coli	92-96
10773222-4	2000	Both benserazide and L-5-hydroxytryptophan (L-5-HTP) were found to produce concentration dependent decreases in AADC activity with K(i) values in the microM range.	5-Hydroxytryptophan	21-42	dopa decarboxylase	Rattus norvegicus	112-116
10773222-4	2000	Both benserazide and L-5-hydroxytryptophan (L-5-HTP) were found to produce concentration dependent decreases in AADC activity with K(i) values in the microM range.	5-Hydroxytryptophan	44-51	dopa decarboxylase	Rattus norvegicus	112-116
10332097-8	1999	In pulse-chase labelling experiments, the conversion of the amidated gastrin G34 to G17 was inhibited by biogenic amine precursors (L-DOPA and 5-hydroxytryptophan).	5-Hydroxytryptophan	143-162	gastrin	Rattus norvegicus	69-76
10089382-1	1999	DOPA decarboxylase is responsible for the synthesis of the key neurotransmitters dopamine and serotonin via decarboxylation of L-3, 4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan, respectively.	5-Hydroxytryptophan	170-191	dopa decarboxylase	Sus scrofa	0-18
11902123-9	2002	The reduction of 5-hydroxytryptophan levels by 33-75% in both in vivo and in vitro studies suggests a decreased activity of TPH.	5-Hydroxytryptophan	17-36	tryptophan hydroxylase 1	Rattus norvegicus	124-127
11148450-2	2001	Aromatic L-amino acid decarboxylase (AADC) gene, the product of which catalyzes the synthesis of serotonin and dopamine from L-5-hydroxytryptophan and L-3,4-dihydroxyphenylalanine, respectively, was characterized.	5-Hydroxytryptophan	125-146	dopa decarboxylase	Homo sapiens	37-41
11011048-0	2000	Serum leptin levels after central and systemic injection of a serotonin precursor, 5-hydroxytryptophan, in mice.	5-Hydroxytryptophan	83-102	leptin	Mus musculus	6-12
11011048-1	2000	Effects of peripheral and central injections of a serotonin (5-hydroxytryptamine, 5-HT) precursor, 5-hydroxytryptophan (5-HTP), on serum leptin levels were studied in mice.	5-Hydroxytryptophan	99-118	leptin	Mus musculus	137-143
11011048-4	2000	The elevation of serum leptin levels in mice induced by the peripheral injection of 5-HTP was inhibited by pretreatment with the peripheral aromatic amino acid decarboxylase inhibitor, benserazide.	5-Hydroxytryptophan	84-89	leptin	Mus musculus	23-29
11019904-17	2000	5-HTP significantly increased PROL plasma levels, and this effect was modified neither by the GABAergic nor by the EAAs receptor antagonists.	5-Hydroxytryptophan	0-5	prolactin	Rattus norvegicus	30-34
10929085-4	2000	In ADX rats, administration of 5-HTP decreased hippocampal mineralocorticoid (MR) and glucocorticoid (GR) receptor numbers 24 h later, while their respective mRNAs were unchanged and these effects of 5-HTP were mediated by 5-HT2 receptors.	5-Hydroxytryptophan	31-36	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	86-114
10821639-4	1999	AADC neurons in the human ACC might transform L-DOPA to dopamine, droxidopa to noradrenaline, and/or 5-hydroxytryptophan to serotonin.	5-Hydroxytryptophan	101-120	dopa decarboxylase	Homo sapiens	0-4
9828005-6	1998	Structural analysis by mass spectrometry revealed that tryptophan 9 of alphaA- and tryptophan 60 of alphaB-crystallin were each converted into hydroxytryptophans (HTRP), N-formylkynurenine (NFK), and kynurenine (KYN).	5-Hydroxytryptophan	143-161	crystallin alpha B	Bos taurus	100-117
9926844-5	1998	The effect of 5-hydroxytryptophan is much greater at night, when TPH and AA-NAT activities are high, than during the day, when the enzyme activities are low.	5-Hydroxytryptophan	14-33	aralkylamine N-acetyltransferase	Gallus gallus	73-79
9926844-6	1998	Similarly, unexpected light exposure at night, which inactivates AA-NAT, significantly reduces the ability of 5-hydroxytryptophan to increase retinal melatonin levels.	5-Hydroxytryptophan	110-129	aralkylamine N-acetyltransferase	Gallus gallus	65-71
9692731-0	1998	D-amphetamine and L-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the alpha2C-adrenergic receptor subtype.	5-Hydroxytryptophan	18-39	adrenergic receptor, alpha 2c	Mus musculus	110-137
9862411-2	1998	The cortisol response to 5-HTP was significantly increased following clomipramine treatment, suggesting that clomipramine, like selective serotonin re-uptake inhibitors (SSRIs), enhances this 5-HT2 receptor mediated response.	5-Hydroxytryptophan	25-30	5-hydroxytryptamine receptor 2A	Homo sapiens	192-206
9692731-10	1998	However, the head twitches induced by L-5-hydroxytryptophan were effectively inhibited by dexmedetomidine in all studied mice, which suggests that alpha2A-adrenoceptors mediate the inhibition of the head twitch response.	5-Hydroxytryptophan	38-59	adrenergic receptor, alpha 2a	Mus musculus	147-154
9555017-5	1998	In response to NSD-1015 (an inhibitor of aromatic L-amino acid decarboxylase, AADC), 5-hydroxytryptophan (5-HTP) levels were substantially elevated in the SN grafted striata as compared with those in the sham grafted controls, which continued even after subsequent administration of L-3,4-dihydroxyphenylalanine (L-DOPA, 100 mg/kg i.p.).	5-Hydroxytryptophan	85-104	dopa decarboxylase	Rattus norvegicus	78-82
9754801-4	1998	administration increased the accumulation of 5-HTP as an index of in vivo TRH activity under the inhibition of aromatic L-amino acid decarboxylase by NSD-1015 in the striatum of both normal control and 6-hydroxydopamine lesioned rats with intrastriatal transplants of fetal ventral mesencephalon (VM).	5-Hydroxytryptophan	45-50	thyrotropin releasing hormone	Rattus norvegicus	74-77
9676898-0	1998	Evidence for an involvement of 5-HT1B receptors in the inhibition of male rat ejaculatory behavior produced by 5-HTP.	5-Hydroxytryptophan	111-116	5-hydroxytryptamine receptor 1B	Rattus norvegicus	31-37
9676898-4	1998	The increased ejaculation latency produced by 5-HTP was fully antagonized by treatment with the 5-HT1B receptor antagonist isamoltane (4 mg/kg s.c.), but not by ritanserin (2 mg/kg s.c.) treatment.	5-Hydroxytryptophan	46-51	5-hydroxytryptamine receptor 1B	Rattus norvegicus	96-102
9676898-5	1998	The selective 5-HT1A receptor antagonist WAY-100635 (0.15 mg/kg s.c.) enhanced the inhibitory actions of 5-HTP on the male rat ejaculatory behavior, and this dose of WAY-100635 fully antagonized 8-OH-DPAT-induced facilitation (0.25 mg/kg s.c.) of the ejaculatory behavior.	5-Hydroxytryptophan	105-110	5-hydroxytryptamine receptor 1A	Rattus norvegicus	14-20
9676898-7	1998	Taken together, the results suggest an inhibitory role for postsynaptic 5-HT1B receptors in the effects produced by 5-HTP on male rat ejaculatory behavior.	5-Hydroxytryptophan	116-121	5-hydroxytryptamine receptor 1B	Rattus norvegicus	72-78
9676898-8	1998	Furthermore, 5-HTP-induced inhibition of male rat ejaculatory behavior is partially controlled by stimulation of inhibitory 5-HT1A autoreceptors, since the effects of 5-HTP were accentuated by treatment with (-)-pindolol, as well as by the more selective 5-HT1A receptor antagonist WAY-100635.	5-Hydroxytryptophan	13-18	5-hydroxytryptamine receptor 1A	Rattus norvegicus	124-130
9676898-8	1998	Furthermore, 5-HTP-induced inhibition of male rat ejaculatory behavior is partially controlled by stimulation of inhibitory 5-HT1A autoreceptors, since the effects of 5-HTP were accentuated by treatment with (-)-pindolol, as well as by the more selective 5-HT1A receptor antagonist WAY-100635.	5-Hydroxytryptophan	13-18	5-hydroxytryptamine receptor 1A	Rattus norvegicus	255-261
9676898-8	1998	Furthermore, 5-HTP-induced inhibition of male rat ejaculatory behavior is partially controlled by stimulation of inhibitory 5-HT1A autoreceptors, since the effects of 5-HTP were accentuated by treatment with (-)-pindolol, as well as by the more selective 5-HT1A receptor antagonist WAY-100635.	5-Hydroxytryptophan	167-172	5-hydroxytryptamine receptor 1A	Rattus norvegicus	124-130
9545000-8	1998	Conventional treatment of BH4 deficiency, i.e. BH4, 5-hydroxytryptophan, and L-DOPA/carbidopa (the last named given in three doses per day), suppresses prolactin levels merely for a few hours.	5-Hydroxytryptophan	52-71	prolactin	Homo sapiens	152-161
9612848-0	1998	Lithium enhancement of the prolactin response to 5-hydroxytryptophan is not reversible by inositol.	5-Hydroxytryptophan	49-68	prolactin	Rattus norvegicus	27-36
9612848-2	1998	Two hundred male albino Sprague-Dawley rats were studied for the lithium and/or inositol effect on 5-HTP induced prolactin release.	5-Hydroxytryptophan	99-104	prolactin	Rattus norvegicus	113-122
9612848-4	1998	Lithium demonstrated a clear augmentation of 5-HTP induced prolactin levels, however no effect of inositol was demonstrated on lithium augmentation of 5-HTP induced prolactin release.	5-Hydroxytryptophan	45-50	prolactin	Rattus norvegicus	59-68
9255851-4	1997	Toward this end, the authors examined plasma cortisol responses to 200 mg (orally) L-5-hydroxy-tryptophan (L-5-HTP) in 10 manic patients both before and after subchronic treatment with valproate.	5-Hydroxytryptophan	83-105	ribosomal protein L5	Homo sapiens	107-114
10065930-6	1998	All of the drugs with a selective affinity at 5-HT1A receptors interacted significantly with 5-hydroxytryptophan.	5-Hydroxytryptophan	93-112	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	46-52
10065930-7	1998	The suppressant effect of 5-hydroxytryptophan was antagonized or reversed by buspirone, a partial agonist at postsynaptic 5-HT1A receptors, and also by the "silent" 5-HT1A receptor antagonist WAY 100635, but not by the full agonist 8-OH-DPAT.	5-Hydroxytryptophan	26-45	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	122-128
10065930-7	1998	The suppressant effect of 5-hydroxytryptophan was antagonized or reversed by buspirone, a partial agonist at postsynaptic 5-HT1A receptors, and also by the "silent" 5-HT1A receptor antagonist WAY 100635, but not by the full agonist 8-OH-DPAT.	5-Hydroxytryptophan	26-45	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	122-137
10065930-12	1998	Administration of 5-hydroxytryptophan may consequently represent a valid approach to analyse further the role of 5-HT agents, in particular those acting at 5-HT1A receptors, in animal models of anxiety.	5-Hydroxytryptophan	18-37	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	156-162
9194044-0	1997	Fluoxetine, but not tricyclic antidepressants, potentiates the 5-hydroxytryptophan-mediated increase in plasma cortisol and prolactin secretion in subjects with major depression or with obsessive compulsive disorder.	5-Hydroxytryptophan	63-82	prolactin	Homo sapiens	124-133
9194044-2	1997	The effects of chronic treatment with fluoxetine or tricyclic antidepressants on the L-5-hydroxytryptophan (200 mg, L-5-HTP; PO)-induced increases in plasma cortisol and prolactin (PRL) concentrations were studied in patients with major depression or obsessive compulsive disorder (OCD).	5-Hydroxytryptophan	85-106	prolactin	Homo sapiens	170-179
9194044-2	1997	The effects of chronic treatment with fluoxetine or tricyclic antidepressants on the L-5-hydroxytryptophan (200 mg, L-5-HTP; PO)-induced increases in plasma cortisol and prolactin (PRL) concentrations were studied in patients with major depression or obsessive compulsive disorder (OCD).	5-Hydroxytryptophan	85-106	prolactin	Homo sapiens	181-184
9194044-3	1997	Administration of L-5-HTP increased plasma cortisol and PRL levels in medicated and unmedicated patients with major depression or OCD.	5-Hydroxytryptophan	18-25	prolactin	Homo sapiens	56-59
9194044-4	1997	The L-5-HTP-induced cortisol and PRL responses were significantly higher in fluoxetine-treated than in tricyclic-treated or unmedicated major depressed patients.	5-Hydroxytryptophan	4-11	prolactin	Homo sapiens	33-36
9194044-6	1997	The L-5-HTP-induced increases in cortisol and PRL in fluoxetine-treated patients with major depression or OCD were not significantly different.	5-Hydroxytryptophan	4-11	prolactin	Homo sapiens	46-49
14655855-2	1997	In this study we tested whether the development of obesity in Wistar rats, given ad libitum cafeteria foods, could be predicted by a low prolactin (PRL) response to 5-hydroxytryptophan (5HTP), as an index of low hypothalamic serotoninergic tonus.	5-Hydroxytryptophan	165-184	prolactin	Rattus norvegicus	148-151
9176374-1	1997	The present study defined the kinetic characteristics of L-3,4-dihydroxyphenylalanine (L-dopa) and L-5-hydroxytryptophan (L-5-HTP) transport and their decarboxylation products, dopamine and 5-hydroxytryptamine (5-HT), respectively, in OK cells.	5-Hydroxytryptophan	99-120	ribosomal protein L5	Homo sapiens	122-129
14655855-2	1997	In this study we tested whether the development of obesity in Wistar rats, given ad libitum cafeteria foods, could be predicted by a low prolactin (PRL) response to 5-hydroxytryptophan (5HTP), as an index of low hypothalamic serotoninergic tonus.	5-Hydroxytryptophan	186-190	prolactin	Rattus norvegicus	148-151
14655855-5	1997	In the tested animals an increase of PRL between 4 and 56 times the basal value was observed 60 min after the 5HTP injection.	5-Hydroxytryptophan	110-114	prolactin	Rattus norvegicus	37-40
8887988-0	1996	Stimulatory effects of L-5-hydroxytryptophan on postdexamethasone beta-endorphin levels in major depression.	5-Hydroxytryptophan	23-44	proopiomelanocortin	Homo sapiens	66-80
8951980-0	1996	The stimulatory and inhibitory components of cocaine"s actions on the 5-HTP-induced 5-HT2A receptor response.	5-Hydroxytryptophan	70-75	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	84-99
8887988-1	1996	Recently it has been shown that acute administration of 200 mg L-5-hydroxytryptophan (L-5-HTP) PO may increase post-dexamethasone (DST) adrenocorticotropic hormone (ACTH) and cortisol levels in major, but not minor, depressed subjects.	5-Hydroxytryptophan	63-84	proopiomelanocortin	Homo sapiens	136-163
8887988-1	1996	Recently it has been shown that acute administration of 200 mg L-5-hydroxytryptophan (L-5-HTP) PO may increase post-dexamethasone (DST) adrenocorticotropic hormone (ACTH) and cortisol levels in major, but not minor, depressed subjects.	5-Hydroxytryptophan	63-84	proopiomelanocortin	Homo sapiens	165-169
8887988-1	1996	Recently it has been shown that acute administration of 200 mg L-5-hydroxytryptophan (L-5-HTP) PO may increase post-dexamethasone (DST) adrenocorticotropic hormone (ACTH) and cortisol levels in major, but not minor, depressed subjects.	5-Hydroxytryptophan	86-93	proopiomelanocortin	Homo sapiens	136-163
8887988-1	1996	Recently it has been shown that acute administration of 200 mg L-5-hydroxytryptophan (L-5-HTP) PO may increase post-dexamethasone (DST) adrenocorticotropic hormone (ACTH) and cortisol levels in major, but not minor, depressed subjects.	5-Hydroxytryptophan	86-93	proopiomelanocortin	Homo sapiens	165-169
8887988-3	1996	It was found that in major, but not minor, depressed subjects, L-5-HTP significantly increased post-DST beta-endorphin concentrations as compared to placebo.	5-Hydroxytryptophan	63-70	proopiomelanocortin	Homo sapiens	104-118
8887988-4	1996	The L-5-HTP-induced post-DST beta-endorphin responses were significantly higher in major than in minor depressed subjects.	5-Hydroxytryptophan	4-11	proopiomelanocortin	Homo sapiens	29-43
8887988-5	1996	There was a significant and positive relationship between L-5-HTP-induced post-DST beta-endorphin and ACTH or cortisol responses.	5-Hydroxytryptophan	58-65	proopiomelanocortin	Homo sapiens	83-97
8887988-5	1996	There was a significant and positive relationship between L-5-HTP-induced post-DST beta-endorphin and ACTH or cortisol responses.	5-Hydroxytryptophan	58-65	proopiomelanocortin	Homo sapiens	102-106
8887988-6	1996	There was a significant and positive relationship between L-5-HTP-induced post-DST beta-endorphin values and the Hamilton Depression Rating Scale (HDRS) score.	5-Hydroxytryptophan	58-65	proopiomelanocortin	Homo sapiens	83-97
8887988-7	1996	The results show that the acute administration of L-5-HTP may increase the escape of beta-endorphin secretion from suppression by dexamethasone in major, but not minor, depression.	5-Hydroxytryptophan	50-57	proopiomelanocortin	Homo sapiens	85-99
8880946-8	1996	5-HTP-induced head twitches (a 5-HT2A effect) were inhibited by repeated paroxetine or imipramine.	5-Hydroxytryptophan	0-5	5-hydroxytryptamine receptor 2A	Rattus norvegicus	31-37
8612503-5	1996	injection of 5-hydroxy-L-tryptophan (1 mg/100 g BW), a precursor of serotonin, was blunted by PACAP-(6-38) (1 nmol/100 g BW, i.v.	5-Hydroxytryptophan	13-35	adenylate cyclase activating polypeptide 1	Rattus norvegicus	94-99
8870031-9	1996	At low doses (0.06-0.25 mg/kg), the 5-HT2A selective agonist, 8-OH DPAT, significantly but partially inhibited 5-HTP-induced HTR.	5-Hydroxytryptophan	111-116	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	36-42
8778905-1	1996	Recently, our laboratory found a significant enhancing effect of L-5-hydroxy-tryptophan (L-5-HTP) on post-dexamethasone (DST) plasma adrenocorticotropic hormone (ACTH) and cortisol levels in major-but not in minor-depression.	5-Hydroxytryptophan	65-87	proopiomelanocortin	Homo sapiens	133-160
8742680-4	1996	After L-5-hydroxytryptophan treatment, serum serotonin and both plasma and mononuclear cell beta-endorphin levels tended to be higher, though not significantly so, than prior to treatment, and the clinical score (frequency x intensity of headache attacks) was significantly lower in both headache groups than at the baseline.	5-Hydroxytryptophan	6-27	proopiomelanocortin	Homo sapiens	92-106
8637392-2	1996	A variety of drugs including precursors of 5HT such as 5HTP, drugs which release 5HT such as fenfluramine and drugs which act directly on 5HT receptors such as ipsapirone increase cortisol and ACTH concentrations.	5-Hydroxytryptophan	55-59	proopiomelanocortin	Homo sapiens	193-197
8831798-1	1996	Using selective monoamine uptake blockers and appropriate selective monoamine receptor antagonists, we have previously shown that cocaine enhances the frequency of 5-HT2A receptor-mediated 5-hydroxytryptophan (5-HTP)-induced head-twitch response (HTR) in mice via inhibition of serotonin uptake.	5-Hydroxytryptophan	189-208	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	164-179
8738578-7	1996	Ketanserin (5-HT2A antagonist) and methysergide (5-HT2C antagonist) blocked 5-HTP-induced prolactin release, but did not block the LH or FSH responses.	5-Hydroxytryptophan	76-81	5-hydroxytryptamine receptor 2A	Rattus norvegicus	12-18
8738578-7	1996	Ketanserin (5-HT2A antagonist) and methysergide (5-HT2C antagonist) blocked 5-HTP-induced prolactin release, but did not block the LH or FSH responses.	5-Hydroxytryptophan	76-81	5-hydroxytryptamine receptor 2C	Rattus norvegicus	49-55
24643372-2	1996	In this study we tested whether the development of obesity in Wistar rats, given ad libitum cafeteria foods, could be predicted by a low prolactin (PRL) response to 5-hydroxytryptophan (5HTP), as an index of low hypothalamic serotoninergic tonus.	5-Hydroxytryptophan	165-184	prolactin	Rattus norvegicus	148-151
24643372-2	1996	In this study we tested whether the development of obesity in Wistar rats, given ad libitum cafeteria foods, could be predicted by a low prolactin (PRL) response to 5-hydroxytryptophan (5HTP), as an index of low hypothalamic serotoninergic tonus.	5-Hydroxytryptophan	186-190	prolactin	Rattus norvegicus	148-151
24643372-5	1996	In the tested animals an increase of PRL between 4 and 56 times the basal value was observed 60 min after the 5HTP injection.	5-Hydroxytryptophan	110-114	prolactin	Rattus norvegicus	37-40
8831798-1	1996	Using selective monoamine uptake blockers and appropriate selective monoamine receptor antagonists, we have previously shown that cocaine enhances the frequency of 5-HT2A receptor-mediated 5-hydroxytryptophan (5-HTP)-induced head-twitch response (HTR) in mice via inhibition of serotonin uptake.	5-Hydroxytryptophan	210-215	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	164-179
8778905-1	1996	Recently, our laboratory found a significant enhancing effect of L-5-hydroxy-tryptophan (L-5-HTP) on post-dexamethasone (DST) plasma adrenocorticotropic hormone (ACTH) and cortisol levels in major-but not in minor-depression.	5-Hydroxytryptophan	65-87	proopiomelanocortin	Homo sapiens	162-166
8778905-1	1996	Recently, our laboratory found a significant enhancing effect of L-5-hydroxy-tryptophan (L-5-HTP) on post-dexamethasone (DST) plasma adrenocorticotropic hormone (ACTH) and cortisol levels in major-but not in minor-depression.	5-Hydroxytryptophan	89-96	proopiomelanocortin	Homo sapiens	133-160
8778905-1	1996	Recently, our laboratory found a significant enhancing effect of L-5-hydroxy-tryptophan (L-5-HTP) on post-dexamethasone (DST) plasma adrenocorticotropic hormone (ACTH) and cortisol levels in major-but not in minor-depression.	5-Hydroxytryptophan	89-96	proopiomelanocortin	Homo sapiens	162-166
7595534-1	1995	Aromatic L-amino acid decarboxylase (AADC) is expressed in a wide variety of tissues, including those where it is known to convert L-DOPA and 5-hydroxytryptophan to dopamine and serotonin, respectively.	5-Hydroxytryptophan	142-161	dopa decarboxylase	Homo sapiens	0-35
8750741-0	1995	The role of 5-HT1D and 5-HT1A receptors in mediating 5-hydroxytryptophan induced myoclonic jerks in guinea pigs.	5-Hydroxytryptophan	53-72	5-hydroxytryptamine receptor 1D	Cavia porcellus	12-18
8750741-0	1995	The role of 5-HT1D and 5-HT1A receptors in mediating 5-hydroxytryptophan induced myoclonic jerks in guinea pigs.	5-Hydroxytryptophan	53-72	5-hydroxytryptamine receptor 1A	Cavia porcellus	23-29
8750741-11	1995	Our data therefore confirm previous reports concerning the effects of 5-HT2A/2C receptor blockade on 5-HTP induced myoclonic jerks and suggest that both 5-HT1D and 5-HT1A receptors play an important role in mediating this behavioural response.	5-Hydroxytryptophan	101-106	5-hydroxytryptamine receptor 1D	Cavia porcellus	153-159
8750741-11	1995	Our data therefore confirm previous reports concerning the effects of 5-HT2A/2C receptor blockade on 5-HTP induced myoclonic jerks and suggest that both 5-HT1D and 5-HT1A receptors play an important role in mediating this behavioural response.	5-Hydroxytryptophan	101-106	5-hydroxytryptamine receptor 1A	Cavia porcellus	164-170
7595534-1	1995	Aromatic L-amino acid decarboxylase (AADC) is expressed in a wide variety of tissues, including those where it is known to convert L-DOPA and 5-hydroxytryptophan to dopamine and serotonin, respectively.	5-Hydroxytryptophan	142-161	dopa decarboxylase	Homo sapiens	37-41
7567987-5	1995	Aromatic L-amino acid decarboxylase catalyzes the decarboxylation of L-5-hydroxytryptophan to serotonin and that of L-3,4-dihydroxyphenylalanine to dopamine.	5-Hydroxytryptophan	69-90	dopa decarboxylase	Homo sapiens	0-35
8545469-5	1995	These data demonstrate that central administration of 5-HT2A/2C antagonists potently attenuate operant response suppression induced with systemically administered 5-HTP or DOI and are in agreement with previous findings suggesting central mediation of 5-HTP-induced operant response suppression.	5-Hydroxytryptophan	163-168	5-hydroxytryptamine receptor 2A	Rattus norvegicus	54-60
8545469-5	1995	These data demonstrate that central administration of 5-HT2A/2C antagonists potently attenuate operant response suppression induced with systemically administered 5-HTP or DOI and are in agreement with previous findings suggesting central mediation of 5-HTP-induced operant response suppression.	5-Hydroxytryptophan	252-257	5-hydroxytryptamine receptor 2A	Rattus norvegicus	54-60
8786639-5	1995	The effects of MKC-242 on decarboxylase inhibitor-induced 5-hydroxytryptophan accumulation and rectal temperature were blocked by the 5-HT1A-receptor antagonist N-tert-butyl-3-(4-(2-methoxyphenyl)piperazin-1-yl)-2-phenylpropana mide.	5-Hydroxytryptophan	58-77	5-hydroxytryptamine receptor 1A	Rattus norvegicus	134-140
7720666-5	1995	When endogenous PRL secretion was stimulated for 7 days with injections of domperidone or 5-hydroxytryptophan, the splenocyte response increased by 48% and 64%, respectively, when injections were given at 9-10 HALO, but did not increase when they were given at 23-0 HALO.	5-Hydroxytryptophan	90-109	prolactin	Mus musculus	16-19
7662110-0	1995	5-Hydroxytryptophan: an absorption and fluorescence probe which is a conservative replacement for [A14 tyrosine] in insulin.	5-Hydroxytryptophan	0-19	insulin	Homo sapiens	116-123
7662110-2	1995	We describe the synthesis of an insulin analog where A14 tyrosine is replaced by a tryptophan analog, 5-hydroxytryptophan.	5-Hydroxytryptophan	102-121	insulin	Homo sapiens	32-39
7662110-3	1995	This insulin is spectrally enhanced since 5-hydroxytryptophan has an absorption band above 300 nm which is at lower energies than the absorption of tryptophan.	5-Hydroxytryptophan	42-61	insulin	Homo sapiens	5-12
7899535-6	1995	It is concluded that L-5-HTP loading may augment ACTH and, consequently, cortisol escape from suppression by dexamethasone in major but not in minor depressed subjects.	5-Hydroxytryptophan	21-28	proopiomelanocortin	Homo sapiens	49-53
8925676-6	1995	However, the anorectic effect of 5-HTP was also antagonized by propranolol (PROP 1mg/kg, i.p.)	5-Hydroxytryptophan	33-38	PROP paired-like homeobox 1	Rattus norvegicus	76-82
7619676-3	1995	Mean urinary excretion rate of 5-HT, which was < 0.7 nmol min-1 before dosing, rose to a peak value of 412 +/- 92 nmol min-1 at the end of 5-HTP infusion and 303 +/- 29 nmol min-1 after administration of glu-5-HTP.	5-Hydroxytryptophan	142-147	CD59 molecule (CD59 blood group)	Homo sapiens	122-127
7619676-3	1995	Mean urinary excretion rate of 5-HT, which was < 0.7 nmol min-1 before dosing, rose to a peak value of 412 +/- 92 nmol min-1 at the end of 5-HTP infusion and 303 +/- 29 nmol min-1 after administration of glu-5-HTP.	5-Hydroxytryptophan	142-147	CD59 molecule (CD59 blood group)	Homo sapiens	122-127
7712159-6	1995	The present findings suggest that (i) AADC in dopaminergic neurons of the SNC and in noradrenergic neurons of the LC can catalyze the in vivo decarboxylation of exogenous L-5HTP to produce 5HT, and (ii) most of the newly produced 5HT in the LC neurons is rapidly degraded by endogenous MAO.	5-Hydroxytryptophan	171-177	dopa decarboxylase	Rattus norvegicus	38-42
7899535-2	1995	L-5-HTP significantly enhanced post-DST ACTH and cortisol secretion in major--but not in minor--depressed subjects.	5-Hydroxytryptophan	0-7	proopiomelanocortin	Homo sapiens	40-44
7899535-4	1995	L-5-HTP administration converted some major depressed ACTH or cortisol suppressors into nonsuppressors.	5-Hydroxytryptophan	0-7	proopiomelanocortin	Homo sapiens	54-58
7899535-5	1995	L-5-HTP stimulated ACTH or cortisol secretion to the same extent in major depressed HPA-axis suppressors and nonsuppressors.	5-Hydroxytryptophan	0-7	proopiomelanocortin	Homo sapiens	19-23
7697371-4	1994	The present result suggests that AADC decarboxylating L-5-hydroxytryptophan to serotonin in physiological conditions is also able to catalyze the in vivo decarboxylation of exogenous L-DOPA.	5-Hydroxytryptophan	54-75	dopa decarboxylase	Rattus norvegicus	33-37
7699211-0	1994	5-Hydroxytryptophan-stimulated prolactin levels in cafeteria diet fed rats: an in vivo evaluation of the central serotonergic tonus.	5-Hydroxytryptophan	0-19	prolactin	Rattus norvegicus	31-40
7699627-1	1994	OBJECTIVE: To determine whether L-5-hydroxytryptophan (L-5-HTP) associated with eosinophiliamyalgia syndrome (EMS) like illness contains impurities in a fashion similar to that described in L-tryptophan associated with EMS.	5-Hydroxytryptophan	32-53	ribosomal protein L5	Homo sapiens	55-62
7699211-2	1994	In this study the central serotonergic tonus in adult male Wistar rats was evaluated in vivo after 6 weeks of feeding a cafeteria diet by the prolactin response to the administration of 5-hydroxytryptophan (5HTP), the immediate serotonin precursor.	5-Hydroxytryptophan	186-205	prolactin	Rattus norvegicus	142-151
7699211-2	1994	In this study the central serotonergic tonus in adult male Wistar rats was evaluated in vivo after 6 weeks of feeding a cafeteria diet by the prolactin response to the administration of 5-hydroxytryptophan (5HTP), the immediate serotonin precursor.	5-Hydroxytryptophan	207-211	prolactin	Rattus norvegicus	142-151
7699211-4	1994	The 5HTP-stimulated prolactin secretion in the cafeteria diet fed rats, determined by the peak value (95.8 +/- 17.2 vs 119.1 +/- 27.0 ng/ml) as well as by the integrated area under the curve (5478 +/- 774 vs 5916 +/- 2275 ng/ml.	5-Hydroxytryptophan	4-8	prolactin	Rattus norvegicus	20-29
8510830-1	1993	Aromatic L-amino acid decarboxylase (AADC) decarboxylates L-DOPA and 5-hydroxytryptophan into dopamine and serotonin, respectively.	5-Hydroxytryptophan	69-88	dopa decarboxylase	Rattus norvegicus	0-35
8229069-3	1993	Administration of 5-hydroxytryptophan and 2-methyl-5-hydroxytryptamine resulted in an increase of the spinal cord TRH content in C3H mice, but not in RMN.	5-Hydroxytryptophan	18-37	thyrotropin releasing hormone	Mus musculus	114-117
8237142-1	1993	Aromatic L-amino acid decarboxylase (AADC) decarboxylates both L-5-hydroxytryptophan to serotonin in serotonergic neurons and pineal cells, and L-dopa to dopamine in catecholaminergic neurons and adrenal medullary cells.	5-Hydroxytryptophan	63-84	dopa decarboxylase	Homo sapiens	0-35
8237142-1	1993	Aromatic L-amino acid decarboxylase (AADC) decarboxylates both L-5-hydroxytryptophan to serotonin in serotonergic neurons and pineal cells, and L-dopa to dopamine in catecholaminergic neurons and adrenal medullary cells.	5-Hydroxytryptophan	63-84	dopa decarboxylase	Homo sapiens	37-41
8237142-5	1993	We expressed a recombinant human AADC in COS cells and proved that the expressed enzyme decarboxylated both L-5-hydroxytryptophan to serotonin and L-dopa to dopamine.	5-Hydroxytryptophan	108-129	dopa decarboxylase	Homo sapiens	33-37
24233453-6	1994	The Trp analogue, 5-hydroxytryptophan (5HW), was incorporated into both oncomodulin mutants to produce Y75(5HW) and 5HW-CDOM33.	5-Hydroxytryptophan	18-37	oncomodulin	Homo sapiens	72-83
8206708-13	1994	The localization of AADC-immunoreactivity in the photoreceptor cell inner segments is possibly related to the biosynthetic pathway of melatonin from 5-hydroxytryptophan.	5-Hydroxytryptophan	149-168	dopa decarboxylase	Rattus norvegicus	20-24
8137917-4	1994	Therefore, the pH-dependent potential interaction of the intraluminal loop domains of the IP3 receptor with chromogranin A was studied by analytical ultracentrifugation utilizing synthetic intraluminal loop peptides of the IP3 receptor labeled with 5-hydroxy-tryptophan at the N-terminus as a chromophore.	5-Hydroxytryptophan	249-269	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	90-102
8510830-1	1993	Aromatic L-amino acid decarboxylase (AADC) decarboxylates L-DOPA and 5-hydroxytryptophan into dopamine and serotonin, respectively.	5-Hydroxytryptophan	69-88	dopa decarboxylase	Rattus norvegicus	37-41
8492290-0	1993	Polarographic and potentiometric investigation of Co(II) complexes with 5-hydroxytryptophan.	5-Hydroxytryptophan	72-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
8492290-1	1993	The formation of the complexes between Co(II) and 5-hydroxytryptophan has been studied by means of polarographic and potentiometric methods.	5-Hydroxytryptophan	50-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-45
8492290-2	1993	The real stability constants of mono and bis-chelato complexes of Co(II) with 5-hydroxytryptophan, obtained by polarographic method, in Britton-Robinson buffer were found to be, log beta 1 = 4.98 and log beta 2 = 8.45.	5-Hydroxytryptophan	78-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-72
8426360-2	1993	Aromatic L-amino acid decarboxylase (AADC) is the enzyme responsible for the final step in the biosynthesis of both dopamine and serotonin via decarboxylation of L-dopa and 5-hydroxy-L-tryptophan, respectively.	5-Hydroxytryptophan	173-195	dopa decarboxylase	Mus musculus	0-35
8426360-2	1993	Aromatic L-amino acid decarboxylase (AADC) is the enzyme responsible for the final step in the biosynthesis of both dopamine and serotonin via decarboxylation of L-dopa and 5-hydroxy-L-tryptophan, respectively.	5-Hydroxytryptophan	173-195	dopa decarboxylase	Mus musculus	37-41
8381907-7	1993	twice a day with 5-hydroxytryptophan (5-HTP; 50 mg/kg) experienced a partial reversal in the decline in the 1.7 kb VIP mRNA seen 24 h after the first pCPA injection.	5-Hydroxytryptophan	17-36	vasoactive intestinal peptide	Rattus norvegicus	115-118
8381907-7	1993	twice a day with 5-hydroxytryptophan (5-HTP; 50 mg/kg) experienced a partial reversal in the decline in the 1.7 kb VIP mRNA seen 24 h after the first pCPA injection.	5-Hydroxytryptophan	38-43	vasoactive intestinal peptide	Rattus norvegicus	115-118
8313393-2	1993	In psychopharmacologic investigations, the compound shows the properties expected of an MAO inhibitor, antagonizing the effects of reserpine, tetrabenazine, and 5-hydroxytryptophan in rats and mice, and suppressing rapid eye movement sleep in cats.	5-Hydroxytryptophan	161-180	monoamine oxidase A	Rattus norvegicus	88-91
8389993-5	1993	5-HTP stimulated GH secretion as early as day 2 postpartum via cholinergic mechanisms not involving GHRH; this pathway was also present in 10-day-old pups.	5-Hydroxytryptophan	0-5	gonadotropin releasing hormone receptor	Rattus norvegicus	17-19
7510111-5	1993	We found that: 1) serum follicle-stimulating hormone (FSH), luteinizing-hormone (LH) and prolactin concentrations increased after 5-HTP administration; 2) serum LH and prolactin concentrations and pituitary prolactin content increased after administration of 8-OH-DPAT.	5-Hydroxytryptophan	130-135	prolactin	Rattus norvegicus	89-98
7510111-5	1993	We found that: 1) serum follicle-stimulating hormone (FSH), luteinizing-hormone (LH) and prolactin concentrations increased after 5-HTP administration; 2) serum LH and prolactin concentrations and pituitary prolactin content increased after administration of 8-OH-DPAT.	5-Hydroxytryptophan	130-135	prolactin	Rattus norvegicus	168-177
7510111-5	1993	We found that: 1) serum follicle-stimulating hormone (FSH), luteinizing-hormone (LH) and prolactin concentrations increased after 5-HTP administration; 2) serum LH and prolactin concentrations and pituitary prolactin content increased after administration of 8-OH-DPAT.	5-Hydroxytryptophan	130-135	prolactin	Rattus norvegicus	168-177
1383030-1	1992	Biosynthetic incorporation of 5-hydroxytryptophan into oncomodulin.	5-Hydroxytryptophan	30-49	oncomodulin	Homo sapiens	55-66
1465439-1	1992	Aromatic L-amino acid decarboxylase (AADC, EC 4.1.1.28) catalyzes the decarboxylation of L-dopa to dopamine in catecholamine cells and 5-hydroxytryptophan to serotonin in serotonin-producing neurons.	5-Hydroxytryptophan	135-154	dopa decarboxylase	Rattus norvegicus	0-35
1465439-1	1992	Aromatic L-amino acid decarboxylase (AADC, EC 4.1.1.28) catalyzes the decarboxylation of L-dopa to dopamine in catecholamine cells and 5-hydroxytryptophan to serotonin in serotonin-producing neurons.	5-Hydroxytryptophan	135-154	dopa decarboxylase	Rattus norvegicus	37-41
1361570-10	1992	PD 118717 decreased the accumulation of 5-hydroxytryptophan in brain, an effect probably due to an agonist action at 5-HT1A receptors.	5-Hydroxytryptophan	40-59	5-hydroxytryptamine receptor 1A	Rattus norvegicus	117-123
1478263-5	1992	produced dose-dependent and significant inhibitory effects on head twitches induced by 5-hydroxytryptophan (5-HTP) plus pargyline, which is a 5-HT2 receptor-dependent behavior in mice.	5-Hydroxytryptophan	87-106	hypothermia due to alcohol sensitivity 2	Mus musculus	144-147
1478263-5	1992	produced dose-dependent and significant inhibitory effects on head twitches induced by 5-hydroxytryptophan (5-HTP) plus pargyline, which is a 5-HT2 receptor-dependent behavior in mice.	5-Hydroxytryptophan	108-113	hypothermia due to alcohol sensitivity 2	Mus musculus	144-147
1478263-6	1992	These results suggest that LS-121 inhibits 5-HTP plus pargyline-induced head twitches by blocking 5-HT2 receptors.	5-Hydroxytryptophan	43-48	hypothermia due to alcohol sensitivity 2	Mus musculus	100-103
1303156-2	1992	The expressed enzyme activity was stereoselective for L-5-hydroxytryptophan and L-DOPA and blocked by NSD-1015 an inhibitor of AADC.	5-Hydroxytryptophan	54-75	dopa decarboxylase	Bos taurus	127-131
1298871-0	1992	[Effect of 5-hydroxytryptophan on the secretion of PRL, GH, TSH and cortisol in obesity].	5-Hydroxytryptophan	11-30	prolactin	Homo sapiens	51-54
1356248-3	1992	Completely analogous effects were found at the somatodendritic 5-HT1A autoreceptor in the raphe nuclei, mediating inhibition of the synthesis of serotonin (5-HT); the full agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and the partial agonist, buspirone were utilized to inhibit the synthesis of 5-HT, as measured by changes in levels of L-5-hydroxytryptophan (5-HTP).	5-Hydroxytryptophan	351-372	5-hydroxytryptamine receptor 1A	Homo sapiens	63-69
1439079-5	1992	The ARP experimented remarkable rises in the normal and hypertensive rats, these values increasing after L-5HTP and falling after p-CPA and 5-6 DHT injections.	5-Hydroxytryptophan	105-111	kidney androgen regulated protein	Rattus norvegicus	4-7
1388251-6	1992	These results indicate that the 5-HTP-induced response suppression shows some pharmacological similarity to DOI-induced response suppression and may be mediated through 5-HT2 and/or 5-HT1C receptors.	5-Hydroxytryptophan	32-37	5-hydroxytryptamine receptor 2C	Rattus norvegicus	182-188
1356248-3	1992	Completely analogous effects were found at the somatodendritic 5-HT1A autoreceptor in the raphe nuclei, mediating inhibition of the synthesis of serotonin (5-HT); the full agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and the partial agonist, buspirone were utilized to inhibit the synthesis of 5-HT, as measured by changes in levels of L-5-hydroxytryptophan (5-HTP).	5-Hydroxytryptophan	374-379	5-hydroxytryptamine receptor 1A	Homo sapiens	63-69
1540578-1	1992	Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines.	5-Hydroxytryptophan	114-135	dopa decarboxylase	Homo sapiens	0-35
1540578-1	1992	Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines.	5-Hydroxytryptophan	114-135	dopa decarboxylase	Homo sapiens	37-41
1504760-12	1992	CONCLUSIONS: (1) chronic, but not acute, administration of PCP facilitates the 5-HTP-induced release of PRL, (2) acute exposure to PCP delays the suckling-induced rise in PRL and appears to inhibit oxytocin release.	5-Hydroxytryptophan	79-84	prolactin	Rattus norvegicus	104-107
1386914-0	1992	Involvement of 5-HT1, 5-HT2, and 5-HT3 receptors in the mediation of the prolactin response to serotonin and 5-hydroxytryptophan.	5-Hydroxytryptophan	109-128	prolactin	Rattus norvegicus	73-82
1727699-11	1992	Injection of Rcho cells 8 days earlier completely inhibited 5-hydroxytryptophan- or DOI-induced PRL release, but did not affect TRH-induced PRL release.	5-Hydroxytryptophan	60-79	prolactin	Rattus norvegicus	96-99
1504760-4	1992	In contrast, chronic administration of PCP facilitated the release of PRL induced by 5-HTP.	5-Hydroxytryptophan	85-90	prolactin	Rattus norvegicus	70-73
1851310-0	1991	Inhibitory effect of ritanserin on the 5-hydroxytryptophan-mediated cortisol, ACTH and prolactin secretion in humans.	5-Hydroxytryptophan	39-58	proopiomelanocortin	Homo sapiens	78-82
2028807-2	1991	At 0800 the postdexamethasone cortisol values were determined and 125 mg L-5-hydroxytryptophan (L-5-HTP) was administered.	5-Hydroxytryptophan	73-94	ribosomal protein L5	Homo sapiens	96-103
1732528-3	1992	The central 5-HT2 receptor antagonism was approximately 1/30 that of 2 when tested for the ability to block head twitches induced by 5-hydroxytryptophan.	5-Hydroxytryptophan	133-152	5-hydroxytryptamine receptor 2A	Homo sapiens	12-26
19215503-2	1991	The serotonin (5-HT) precursor 5-hydroxy-L-tryptophan (5-HTP) and the 5-HT receptor agonist quipazine maleate stimulated serum GH levels in 2-day-old rat pups separated from their mothers for 6 h. The increase in serum GH during suckling was further elevated by 5-HTP.	5-Hydroxytryptophan	31-53	gonadotropin releasing hormone receptor	Rattus norvegicus	127-129
19215503-2	1991	The serotonin (5-HT) precursor 5-hydroxy-L-tryptophan (5-HTP) and the 5-HT receptor agonist quipazine maleate stimulated serum GH levels in 2-day-old rat pups separated from their mothers for 6 h. The increase in serum GH during suckling was further elevated by 5-HTP.	5-Hydroxytryptophan	55-60	gonadotropin releasing hormone receptor	Rattus norvegicus	127-129
19215503-2	1991	The serotonin (5-HT) precursor 5-hydroxy-L-tryptophan (5-HTP) and the 5-HT receptor agonist quipazine maleate stimulated serum GH levels in 2-day-old rat pups separated from their mothers for 6 h. The increase in serum GH during suckling was further elevated by 5-HTP.	5-Hydroxytryptophan	55-60	gonadotropin releasing hormone receptor	Rattus norvegicus	219-221
19215503-5	1991	Moreover, in separated pups, ATR prevented the increase in serum GH induced by 5-HTP.	5-Hydroxytryptophan	79-84	gonadotropin releasing hormone receptor	Rattus norvegicus	65-67
1912990-7	1991	ID50 values of the ten antagonists against 5-hydroxytryptophan (5-HTP) + carbidopa-induced head shakes (a 5-HT2-mediated response) correlated significantly (r = 0.81, n = 10, P less than 0.01) with their affinities for 5-HT2 but not for 5-HT1A, 5-HT1B, 5-HT1C or 5-HT1D receptors.	5-Hydroxytryptophan	43-62	5-hydroxytryptamine receptor 1A	Rattus norvegicus	237-243
1912990-7	1991	ID50 values of the ten antagonists against 5-hydroxytryptophan (5-HTP) + carbidopa-induced head shakes (a 5-HT2-mediated response) correlated significantly (r = 0.81, n = 10, P less than 0.01) with their affinities for 5-HT2 but not for 5-HT1A, 5-HT1B, 5-HT1C or 5-HT1D receptors.	5-Hydroxytryptophan	43-62	5-hydroxytryptamine receptor 1B	Rattus norvegicus	245-251
1912990-7	1991	ID50 values of the ten antagonists against 5-hydroxytryptophan (5-HTP) + carbidopa-induced head shakes (a 5-HT2-mediated response) correlated significantly (r = 0.81, n = 10, P less than 0.01) with their affinities for 5-HT2 but not for 5-HT1A, 5-HT1B, 5-HT1C or 5-HT1D receptors.	5-Hydroxytryptophan	43-62	5-hydroxytryptamine receptor 2C	Rattus norvegicus	253-259
1912990-7	1991	ID50 values of the ten antagonists against 5-hydroxytryptophan (5-HTP) + carbidopa-induced head shakes (a 5-HT2-mediated response) correlated significantly (r = 0.81, n = 10, P less than 0.01) with their affinities for 5-HT2 but not for 5-HT1A, 5-HT1B, 5-HT1C or 5-HT1D receptors.	5-Hydroxytryptophan	43-62	5-hydroxytryptamine receptor 1D	Rattus norvegicus	263-269
1797228-1	1991	Aromatic L-amino acid decarboxylase (AADC) is responsible for the conversion of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are important neurotransmitters.	5-Hydroxytryptophan	122-143	dopa decarboxylase	Rattus norvegicus	0-35
1797228-1	1991	Aromatic L-amino acid decarboxylase (AADC) is responsible for the conversion of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are important neurotransmitters.	5-Hydroxytryptophan	122-143	dopa decarboxylase	Rattus norvegicus	37-41
1851310-3	1991	A borderline effect of 5-HTP on plasma ACTH levels was found.	5-Hydroxytryptophan	23-28	proopiomelanocortin	Homo sapiens	39-43
1851310-7	1991	These data are suggestive that 5-HTP stimulates cortisol secretion in man via 5-HT2/5-HT1c receptor mechanisms.	5-Hydroxytryptophan	31-36	5-hydroxytryptamine receptor 2C	Homo sapiens	84-90
1851310-0	1991	Inhibitory effect of ritanserin on the 5-hydroxytryptophan-mediated cortisol, ACTH and prolactin secretion in humans.	5-Hydroxytryptophan	39-58	prolactin	Homo sapiens	87-96
1708134-1	1990	In the present work we examined the effect of the neutralization of endogenous substance P by the administration of an anti-substance P serum (ASPS) on GABA concentration in the anterior pituitary in hyperprolactinemic conditions induced by 5-hydroxytryptophan or by grafting anterior pituitaries.	5-Hydroxytryptophan	241-260	casein kinase 1 delta	Homo sapiens	143-147
2081822-1	1990	By indirect immunohistochemistry, the present study examined the distribution of neuronal structures in the cat medulla oblongata, pons, and midbrain, showing immunoreactivity to aromatic L-amino acid decarboxylase (AADC), which catalyzes the conversion of L-3, 4-dihydroxyphenylalanine (L-DOPA) to dopamine, and 5-hydroxytryptophan to serotonin (5HT).	5-Hydroxytryptophan	313-332	dopa decarboxylase	Rattus norvegicus	188-214
2081822-1	1990	By indirect immunohistochemistry, the present study examined the distribution of neuronal structures in the cat medulla oblongata, pons, and midbrain, showing immunoreactivity to aromatic L-amino acid decarboxylase (AADC), which catalyzes the conversion of L-3, 4-dihydroxyphenylalanine (L-DOPA) to dopamine, and 5-hydroxytryptophan to serotonin (5HT).	5-Hydroxytryptophan	313-332	dopa decarboxylase	Rattus norvegicus	216-220
2207701-5	1990	Spinal 5-HT1C receptor upregulation may contribute to the behavioral supersensitivity to L-5-hydroxytryptophan (L-5-HTP) in rats with 5,7-DHT lesions.	5-Hydroxytryptophan	89-110	5-hydroxytryptamine receptor 2C	Rattus norvegicus	7-13
2243617-2	1990	Trp-P-2 inhibited the enzyme activity toward L-DOPA more markedly than that toward 5-hydroxytryptophan.	5-Hydroxytryptophan	83-102	polycystin 2, transient receptor potential cation channel	Homo sapiens	0-7
2224538-2	1990	The IP administration of 5-HTP produced a transient increase (only at 45 min after the injection) in glutamate decarboxylase activity (GAD) of MBH and in GABA concentration in anterior pituitary.	5-Hydroxytryptophan	25-30	glutamate-ammonia ligase	Rattus norvegicus	101-124
2207690-5	1990	Basal and KCl- (28 mM) stimulated LH-RH release by incubated hypothalamic fragments was significantly enhanced when 5-HTP was injected previously to 14-day-old animals.	5-Hydroxytryptophan	116-121	gonadotropin releasing hormone 1	Rattus norvegicus	34-39
2207690-6	1990	In 30-day-old rats, 5-HTP treatment did not modify basal LH-RH release, and decreased the KCl-stimulated LH-RH output.	5-Hydroxytryptophan	20-25	gonadotropin releasing hormone 1	Rattus norvegicus	105-110
2207701-5	1990	Spinal 5-HT1C receptor upregulation may contribute to the behavioral supersensitivity to L-5-hydroxytryptophan (L-5-HTP) in rats with 5,7-DHT lesions.	5-Hydroxytryptophan	112-119	5-hydroxytryptamine receptor 2C	Rattus norvegicus	7-13
2142615-6	1990	Behavioral supersensitivity to 5-HTP, which was attributable to 5-HT1A, 5-HT2,1C, and possibly to other 5-HT receptors, was orders of magnitude greater than that elicited by direct receptor agonists and more clearly differentiated between rats with 5,7-DHT lesions and their controls, and between routes of 5,7-DHT injections, than responses to 5-HT agonists at the dose studied.	5-Hydroxytryptophan	31-36	5-hydroxytryptamine receptor 1A	Rattus norvegicus	64-70
2139731-8	1990	In both patients and controls, the 5HTP infusion led to substantial increases in plasma cortisol and beta-endorphin levels, while the plasma MHPG level was unchanged.	5-Hydroxytryptophan	35-39	proopiomelanocortin	Homo sapiens	101-115
1697619-8	1990	The levels of 5HTP and 5HIAA were significantly suppressed by IFN-gamma, either alone or in combination with ISO.	5-Hydroxytryptophan	14-18	interferon gamma	Rattus norvegicus	62-71
2106098-1	1990	The administration of 5-hydroxytryptophan (5-HTP) induced a prolactin release in male and female prepubertal rats at 20 days of age.	5-Hydroxytryptophan	22-41	prolactin	Rattus norvegicus	60-69
2106098-1	1990	The administration of 5-hydroxytryptophan (5-HTP) induced a prolactin release in male and female prepubertal rats at 20 days of age.	5-Hydroxytryptophan	43-48	prolactin	Rattus norvegicus	60-69
2106098-3	1990	Neonatal androgenization of the females significantly increased the release of prolactin induced by 5-HTP treatment compared to the values observed in males; thus, the neonatal exposure to androgens seems to be responsible for the sexual differences in the prolactin response to 5-HTP.	5-Hydroxytryptophan	100-105	prolactin	Rattus norvegicus	79-88
2106098-3	1990	Neonatal androgenization of the females significantly increased the release of prolactin induced by 5-HTP treatment compared to the values observed in males; thus, the neonatal exposure to androgens seems to be responsible for the sexual differences in the prolactin response to 5-HTP.	5-Hydroxytryptophan	100-105	prolactin	Rattus norvegicus	257-266
2106098-3	1990	Neonatal androgenization of the females significantly increased the release of prolactin induced by 5-HTP treatment compared to the values observed in males; thus, the neonatal exposure to androgens seems to be responsible for the sexual differences in the prolactin response to 5-HTP.	5-Hydroxytryptophan	279-284	prolactin	Rattus norvegicus	79-88
2106098-3	1990	Neonatal androgenization of the females significantly increased the release of prolactin induced by 5-HTP treatment compared to the values observed in males; thus, the neonatal exposure to androgens seems to be responsible for the sexual differences in the prolactin response to 5-HTP.	5-Hydroxytryptophan	279-284	prolactin	Rattus norvegicus	257-266
2106098-6	1990	The administration of testosterone to castrated rats markedly increased the prolactin release response to 5-HTP.	5-Hydroxytryptophan	106-111	prolactin	Rattus norvegicus	76-85
2143059-6	1990	In rat, the serotonin receptor antagonist metergoline decreased basal concentrations of the opioid peptide and blocked the increase of beta-endorphin concentrations induced by the serotonin precursor 5-hydroxytryptophan and the tricyclic antidepressant chlorimipramine.	5-Hydroxytryptophan	200-219	proopiomelanocortin	Homo sapiens	135-149
2253486-8	1990	In the presence of 5-hydroxytryptophan (5-HTP) only the DDC activity from human kidney is remarkably reduced.	5-Hydroxytryptophan	19-38	dopa decarboxylase	Homo sapiens	56-59
2253486-8	1990	In the presence of 5-hydroxytryptophan (5-HTP) only the DDC activity from human kidney is remarkably reduced.	5-Hydroxytryptophan	40-45	dopa decarboxylase	Homo sapiens	56-59
10556680-0	1999	The serotonin precursor 5-hydroxytryptophan elevates serum leptin levels in mice.	5-Hydroxytryptophan	24-43	leptin	Mus musculus	59-65
33808712-1	2021	Aromatic amino acid decarboxylase (AADC) deficiency is a rare, autosomal recessive neurometabolic disorder caused by mutations in the DDC gene, leading to a deficit of AADC, a pyridoxal 5"-phosphate requiring enzyme that catalyzes the decarboxylation of L-Dopa and L-5-hydroxytryptophan in dopamine and serotonin, respectively.	5-Hydroxytryptophan	265-286	dopa decarboxylase	Homo sapiens	35-39
33808712-1	2021	Aromatic amino acid decarboxylase (AADC) deficiency is a rare, autosomal recessive neurometabolic disorder caused by mutations in the DDC gene, leading to a deficit of AADC, a pyridoxal 5"-phosphate requiring enzyme that catalyzes the decarboxylation of L-Dopa and L-5-hydroxytryptophan in dopamine and serotonin, respectively.	5-Hydroxytryptophan	265-286	dopa decarboxylase	Homo sapiens	168-172
10556680-1	1999	The effects of a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) on serum leptin levels were investigated in mice.	5-Hydroxytryptophan	44-63	leptin	Mus musculus	81-87
10556680-1	1999	The effects of a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) on serum leptin levels were investigated in mice.	5-Hydroxytryptophan	65-70	leptin	Mus musculus	81-87
10556680-2	1999	5-HTP dose dependently increased serum leptin levels in mice.	5-Hydroxytryptophan	0-5	leptin	Mus musculus	39-45
34952363-0	2022	Effect of process parameters and surfactant additives on the obtained activity of recombinant tryptophan hydroxylase (TPH1) for enzymatic synthesis of 5-hydroxytryptophan (5-HTP).	5-Hydroxytryptophan	151-170	tryptophan hydroxylase 1	Homo sapiens	118-122
34952363-0	2022	Effect of process parameters and surfactant additives on the obtained activity of recombinant tryptophan hydroxylase (TPH1) for enzymatic synthesis of 5-hydroxytryptophan (5-HTP).	5-Hydroxytryptophan	172-177	tryptophan hydroxylase 1	Homo sapiens	118-122
34952363-2	2022	In this work, we studied the heterologous production of Human tryptophan hydroxylase (TPH1) in Escherichia coli, for the synthesis of 5-hydroxytryptophan (5-HTP) from Tryptophan (Trp).	5-Hydroxytryptophan	134-153	tryptophan hydroxylase 1	Homo sapiens	86-90
34952363-2	2022	In this work, we studied the heterologous production of Human tryptophan hydroxylase (TPH1) in Escherichia coli, for the synthesis of 5-hydroxytryptophan (5-HTP) from Tryptophan (Trp).	5-Hydroxytryptophan	155-160	tryptophan hydroxylase 1	Homo sapiens	86-90
34952363-3	2022	To quantify TPH1 activity, a simple fluorescence-based microtiter plate assay was established, based on the changes in fluorescence emission at 340 nm between substrate and product when excited at 310 nm, allowing quick and reliable quantification of released 5-HTP.	5-Hydroxytryptophan	260-265	tryptophan hydroxylase 1	Homo sapiens	12-16
34952363-9	2022	Our results establish a base for a biocatalytic approach as a potential alternative process for the synthesis of 5-HTP using recombinant TPH1.	5-Hydroxytryptophan	113-118	tryptophan hydroxylase 1	Homo sapiens	137-141
34965441-6	2022	We detected PFC metabolite levels by liquid chromatography-tandem mass spectrometry and found significant upregulation of 5-hydroxyindoleacetic acid, kynurenine, 5-hydroxytryptamine, ornithine and glutamine, and downregulation of 5-hydroxytryptophan, glutamic acid and aspartic acid in PEDF-overexpressing mice compared with control mice, in which no such changes were detected.	5-Hydroxytryptophan	230-249	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	286-290
2559587-7	1989	The amplitudes of the cortisol, ACTH and PRL responses to L-5-HTP were significantly and positively correlated.	5-Hydroxytryptophan	58-65	proopiomelanocortin	Homo sapiens	32-36
34715572-1	2021	5-hydroxytryptophan (5HTP) and 3-O-methyldopa (3OMD) are CSF diagnostic biomarkers of the defect of aromatic L-amino acid decarboxylase (AADC), a rare inherited disorder of neurotransmitter synthesis which, if untreated, results in severely disabling neurological impairment.	5-Hydroxytryptophan	0-19	dopa decarboxylase	Homo sapiens	109-135
34715572-1	2021	5-hydroxytryptophan (5HTP) and 3-O-methyldopa (3OMD) are CSF diagnostic biomarkers of the defect of aromatic L-amino acid decarboxylase (AADC), a rare inherited disorder of neurotransmitter synthesis which, if untreated, results in severely disabling neurological impairment.	5-Hydroxytryptophan	0-19	dopa decarboxylase	Homo sapiens	137-141
34715572-1	2021	5-hydroxytryptophan (5HTP) and 3-O-methyldopa (3OMD) are CSF diagnostic biomarkers of the defect of aromatic L-amino acid decarboxylase (AADC), a rare inherited disorder of neurotransmitter synthesis which, if untreated, results in severely disabling neurological impairment.	5-Hydroxytryptophan	21-25	dopa decarboxylase	Homo sapiens	109-135
34715572-1	2021	5-hydroxytryptophan (5HTP) and 3-O-methyldopa (3OMD) are CSF diagnostic biomarkers of the defect of aromatic L-amino acid decarboxylase (AADC), a rare inherited disorder of neurotransmitter synthesis which, if untreated, results in severely disabling neurological impairment.	5-Hydroxytryptophan	21-25	dopa decarboxylase	Homo sapiens	137-141
34281987-7	2021	Metabolomics analysis indicated that GCH1 overexpression reprogrammed tryptophan metabolism, resulting in L-5-hydroxytryptophan (5-HTP) accumulation in the cytoplasm accompanied by kynurenine accumulation and tryptophan reduction in the supernatant.	5-Hydroxytryptophan	106-127	GTP cyclohydrolase 1	Homo sapiens	37-41
34281987-7	2021	Metabolomics analysis indicated that GCH1 overexpression reprogrammed tryptophan metabolism, resulting in L-5-hydroxytryptophan (5-HTP) accumulation in the cytoplasm accompanied by kynurenine accumulation and tryptophan reduction in the supernatant.	5-Hydroxytryptophan	129-134	GTP cyclohydrolase 1	Homo sapiens	37-41
34281987-8	2021	Subsequently, aryl hydrocarbon receptor, activated by 5-HTP, bound to the promoter of indoleamine 2,3-dioxygenase 1 (IDO1) and thus enhanced the transcription of IDO1.	5-Hydroxytryptophan	54-59	aryl hydrocarbon receptor	Homo sapiens	14-39
34281987-8	2021	Subsequently, aryl hydrocarbon receptor, activated by 5-HTP, bound to the promoter of indoleamine 2,3-dioxygenase 1 (IDO1) and thus enhanced the transcription of IDO1.	5-Hydroxytryptophan	54-59	indoleamine 2,3-dioxygenase 1	Homo sapiens	86-115
34281987-8	2021	Subsequently, aryl hydrocarbon receptor, activated by 5-HTP, bound to the promoter of indoleamine 2,3-dioxygenase 1 (IDO1) and thus enhanced the transcription of IDO1.	5-Hydroxytryptophan	54-59	indoleamine 2,3-dioxygenase 1	Homo sapiens	117-121
34281987-8	2021	Subsequently, aryl hydrocarbon receptor, activated by 5-HTP, bound to the promoter of indoleamine 2,3-dioxygenase 1 (IDO1) and thus enhanced the transcription of IDO1.	5-Hydroxytryptophan	54-59	indoleamine 2,3-dioxygenase 1	Homo sapiens	162-166
35235945-2	2022	Serotonin (5-hydroxytryphtamine, 5-HT), the product of 5-hydroxy-l-tryptophan (5-HTP) catalysed by tryptophan hydroxylase 1 (TPH1), is a multifunctional monoamine thought to be a homeostatic regulator of the animal.	5-Hydroxytryptophan	55-77	tryptophan 5-hydroxylase 1	Capra hircus	99-123
35235945-2	2022	Serotonin (5-hydroxytryphtamine, 5-HT), the product of 5-hydroxy-l-tryptophan (5-HTP) catalysed by tryptophan hydroxylase 1 (TPH1), is a multifunctional monoamine thought to be a homeostatic regulator of the animal.	5-Hydroxytryptophan	55-77	tryptophan 5-hydroxylase 1	Capra hircus	125-129
35235945-2	2022	Serotonin (5-hydroxytryphtamine, 5-HT), the product of 5-hydroxy-l-tryptophan (5-HTP) catalysed by tryptophan hydroxylase 1 (TPH1), is a multifunctional monoamine thought to be a homeostatic regulator of the animal.	5-Hydroxytryptophan	79-84	tryptophan 5-hydroxylase 1	Capra hircus	99-123
35235945-2	2022	Serotonin (5-hydroxytryphtamine, 5-HT), the product of 5-hydroxy-l-tryptophan (5-HTP) catalysed by tryptophan hydroxylase 1 (TPH1), is a multifunctional monoamine thought to be a homeostatic regulator of the animal.	5-Hydroxytryptophan	79-84	tryptophan 5-hydroxylase 1	Capra hircus	125-129
35235945-8	2022	The 5-HTP injection group had greater serum calcium concentration on d 4 and greater serum parathyroid hormone related protein (PTHrP) on d -5, -4, -1, 3, 4, and 5 compared to the saline injection group (P <0.05).	5-Hydroxytryptophan	4-9	parathyroid hormone-related protein	Capra hircus	91-126
35235945-8	2022	The 5-HTP injection group had greater serum calcium concentration on d 4 and greater serum parathyroid hormone related protein (PTHrP) on d -5, -4, -1, 3, 4, and 5 compared to the saline injection group (P <0.05).	5-Hydroxytryptophan	4-9	parathyroid hormone-related protein	Capra hircus	128-133
35111753-4	2021	Tph1 gene, which encodes the rate-limiting enzyme for peripheral 5-hydroxytryptophan (5-HT) synthesis, was knocked out in mice to simulate peripheral 5-HT deficiency.	5-Hydroxytryptophan	65-84	tryptophan hydroxylase 1	Mus musculus	0-4
35111753-4	2021	Tph1 gene, which encodes the rate-limiting enzyme for peripheral 5-hydroxytryptophan (5-HT) synthesis, was knocked out in mice to simulate peripheral 5-HT deficiency.	5-Hydroxytryptophan	86-90	tryptophan hydroxylase 1	Mus musculus	0-4
35111753-9	2021	Exogenous 5-HT intervention increased LPS-induced NET formation when Tph1 -/- platelets were co-cultured with WT neutrophils.	5-Hydroxytryptophan	10-14	tryptophan hydroxylase 1	Mus musculus	69-73
2559587-0	1989	Sex-linked differences in cortisol, ACTH and prolactin responses to 5-hydroxy-tryptophan in healthy controls and minor and major depressed patients.	5-Hydroxytryptophan	68-88	prolactin	Homo sapiens	45-54
34649169-10	2021	One other key gene was dopa decarboxylase (Ddc), which catalyzes conversion of L-5-hydroxytryptophan to 5-HT.	5-Hydroxytryptophan	79-100	dopa decarboxylase	Mus musculus	23-41
34649169-10	2021	One other key gene was dopa decarboxylase (Ddc), which catalyzes conversion of L-5-hydroxytryptophan to 5-HT.	5-Hydroxytryptophan	79-100	dopa decarboxylase	Mus musculus	43-46
34158618-6	2021	Strikingly, treatment of Cbln2 KO mice with the serotonin precursor 5-hydroxytryptophan or the serotonin reuptake-inhibitor fluoxetine alleviated compulsive behaviors.	5-Hydroxytryptophan	68-87	cerebellin 2 precursor protein	Mus musculus	25-30
34149997-6	2021	Guanosine dose-dependently reduced 5-HTP-induced wet dog shakes (WDS) and other serotonin syndromes (SS) behaviors, indicating that it might block serotonin 5-HT1A or 5-HT2A receptors.	5-Hydroxytryptophan	35-40	5-hydroxytryptamine receptor 2A	Canis lupus familiaris	167-173
35354689-7	2022	Furthermore, the serotonin content in the cortex and 5-hydroxytryptophan-induced head twitch response were both reduced in PRDX6-Tg mice.	5-Hydroxytryptophan	53-72	peroxiredoxin 6	Mus musculus	123-128
35006225-4	2022	The L. lactis strain WHH2078 increased to high levels the 5-HT precursor 5-hydroxytryptophan (5-HTP) and the expression of tryptophan hydroxylase 1 (Tph1), which converts tryptophan to 5-HTP in RIN14B cells.	5-Hydroxytryptophan	185-190	tryptophan hydroxylase 1	Mus musculus	149-153
2506582-0	1989	Chronic administration of thyrotropin-releasing hormone enhances the sensitivity of lumbar motoneurons to 5-hydroxytryptophan in the rat.	5-Hydroxytryptophan	106-125	thyrotropin releasing hormone	Rattus norvegicus	26-55
2789091-5	1989	DRN-ES produced a significant increase in 5-HTP accumulation in the medial preoptic (MPN) and paraventricular nuclei (PVN), but not in the suprachiasmatic nucleus (SCN), arcuate nucleus (ARC) or median eminence (ME).	5-Hydroxytryptophan	42-47	serine protease 27	Rattus norvegicus	85-88
2746511-3	1989	Direct 5-HT1A agonists 8-hydroxy-2-(di-n-propylamino)tetralin and 5-methoxy-N,N-dimethyltryptamine and the 5-HT precursor 5-hydroxytryptophan all increased the reinforcement rate.	5-Hydroxytryptophan	122-141	5-hydroxytryptamine receptor 1A	Rattus norvegicus	7-13
2506582-1	1989	The influence of a single intraperitoneal injection or of a three-week intrathecal infusion of thyrotropin-releasing hormone (TRH) was studied on the excitatory effect of DL-5-hydroxytryptophan (5-HTP) (20-100 mg/kg IP) on lumbar motoneurons.	5-Hydroxytryptophan	171-193	thyrotropin releasing hormone	Rattus norvegicus	126-129
2506582-4	1989	However, a three-week infusion of TRH in the lumbar subarachnoid space caused a 300% increase in the response to 5-HTP, while denervation alone caused only an increase of 160%.	5-Hydroxytryptophan	113-118	thyrotropin releasing hormone	Rattus norvegicus	34-37
2565817-8	1989	Control experiments indicate that inhibition of 5-HTP accumulation by EMD 49,980 is induced mainly via direct activation of 5-HT1A receptors, although some contribution due to 5-HT uptake inhibition is likely.	5-Hydroxytryptophan	48-53	5-hydroxytryptamine receptor 1A	Rattus norvegicus	124-130
3264239-8	1988	Injection of 5-hydroxytryptophan, a serotonin precursor, increased PRL levels at all times examined.	5-Hydroxytryptophan	13-32	prolactin	Rattus norvegicus	67-70
2788831-7	1989	It is possible that 5-hydroxytryptophan is decarboxylated to serotonin by aromatic L-amino acid decarboxylase but rapidly degraded by monoamine oxidase-A, the enzyme which preferentially deaminates serotonin.	5-Hydroxytryptophan	20-39	monoamine oxidase A	Felis catus	134-153
3141816-1	1988	The accumulation rates of 3,4"-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) after inhibition of aromatic amino acid decarboxylase (AADC) by 3-hydroxybenzylhydrazine (NSD 1015) or 1-(DL-seryl)-2- (2,3,4-trihydroxybenzyl)hydrazine (Ro 4-4602) have widely been used as measurements of the in vivo synthesis rates of monoamines.	5-Hydroxytryptophan	86-91	dopa decarboxylase	Rattus norvegicus	148-152
3151164-11	1988	Although dopa and 5-hydroxytryptophan are substrates for the same enzyme, aromatic L-amino-acid decarboxylase, simultaneous infusions of both amino acids at comparable rates gave no evidence of competitive inhibition of amine synthesis.	5-Hydroxytryptophan	18-37	dopa decarboxylase	Rattus norvegicus	74-109
2467272-2	1988	Administration of the serotonin precursor, 5-hydroxytryptophan (5-HTP; 250 mg/kg ip) or pargyline (5 mg/kg ip) with 5-HTP (100 mg/kg ip) significantly increased serum prolactin concentration.	5-Hydroxytryptophan	43-62	prolactin	Rattus norvegicus	167-176
3265988-1	1988	In an open study 25 depressed patients were treated with L-5-hydroxytryptophan (L-5-HTP) either alone or in combination with a peripheral decarboxylase inhibitor.	5-Hydroxytryptophan	57-78	ribosomal protein L5	Homo sapiens	80-87
2467272-2	1988	Administration of the serotonin precursor, 5-hydroxytryptophan (5-HTP; 250 mg/kg ip) or pargyline (5 mg/kg ip) with 5-HTP (100 mg/kg ip) significantly increased serum prolactin concentration.	5-Hydroxytryptophan	64-69	prolactin	Rattus norvegicus	167-176
2467272-2	1988	Administration of the serotonin precursor, 5-hydroxytryptophan (5-HTP; 250 mg/kg ip) or pargyline (5 mg/kg ip) with 5-HTP (100 mg/kg ip) significantly increased serum prolactin concentration.	5-Hydroxytryptophan	116-121	prolactin	Rattus norvegicus	167-176
2961582-2	1987	(-)-CM-11 and (+)-CM-12 inhibited dose dependently in all brain parts the accumulation of 5-hydroxytryptophan following decarboxylase inhibition.	5-Hydroxytryptophan	90-109	Cardiac mass QTL 11	Rattus norvegicus	4-9
3500688-1	1987	A double-blind random-ordered comparison of the effects of placebo and 5-hydroxytryptophan (200 mg, orally) in ten depressed patients with seasonal affective disorder (SAD) and ten controls disclosed slightly but significantly higher basal levels of serum prolactin and a trend toward higher basal levels of serum cortisol in the patients with SAD compared with controls.	5-Hydroxytryptophan	71-90	prolactin	Homo sapiens	256-265
3500688-2	1987	After administration of 5-HTP, the cortisol level significantly increased and the prolactin level significantly decreased in both patients and controls.	5-Hydroxytryptophan	24-29	prolactin	Homo sapiens	82-91
2961582-2	1987	(-)-CM-11 and (+)-CM-12 inhibited dose dependently in all brain parts the accumulation of 5-hydroxytryptophan following decarboxylase inhibition.	5-Hydroxytryptophan	90-109	Cardiac mass QTL 12	Rattus norvegicus	18-23
2963066-2	1987	The exaggerated dipsogenic response of DOCA-treated rats to administration of angiotensin II (AII, 50 and 100 micrograms/kg, s.c.) was also reduced by treatment with L-5-HTP (4.2 and 8.4 mg/day).	5-Hydroxytryptophan	166-173	angiotensinogen	Rattus norvegicus	78-92
2963066-2	1987	The exaggerated dipsogenic response of DOCA-treated rats to administration of angiotensin II (AII, 50 and 100 micrograms/kg, s.c.) was also reduced by treatment with L-5-HTP (4.2 and 8.4 mg/day).	5-Hydroxytryptophan	166-173	angiotensinogen	Rattus norvegicus	94-97
2963066-3	1987	The specific binding of AII to its receptors in membranes from the diencephalon of the brain was increased significantly above control level by chronic treatment with DOCA, but was returned to control level by concomitant treatment with L-5-HTP.	5-Hydroxytryptophan	237-244	angiotensinogen	Rattus norvegicus	24-27
3676757-0	1987	Prolactin secretion in posterior pituitary lobectomized rats: differential effects of 5-hydroxytryptophan and ether.	5-Hydroxytryptophan	86-105	prolactin	Rattus norvegicus	0-9
3676757-12	1987	of 5-HTP, also showed marked and similar elevations of plasma PRL levels 12 days after surgery.	5-Hydroxytryptophan	3-8	prolactin	Rattus norvegicus	62-65
3676757-15	1987	These results indicate that the 5-HTP-induced rise in plasma PRL levels is independent of the posterior pituitary, regardless of the sex, the route of drug administration or the length of time after surgery.	5-Hydroxytryptophan	32-37	prolactin	Rattus norvegicus	61-64
3676757-17	1987	The evidence that the PRL responses to 5-HTP and to ether might be mediated via different neuronal mechanisms is discussed.	5-Hydroxytryptophan	39-44	prolactin	Rattus norvegicus	22-25
2445457-9	1987	Substance P reduced by almost half the subsequent response to 5-HTP, 1 hour and 24 hours later.	5-Hydroxytryptophan	62-67	tachykinin precursor 1	Homo sapiens	0-11
2445457-10	1987	TRH given acutely did not modify the response to 5-HTP but given chronically for twenty one days by means of Alzet minipump, markedly increased the response to 5-HTP.	5-Hydroxytryptophan	160-165	thyrotropin releasing hormone	Homo sapiens	0-3
2437427-6	1987	These results indicate that serotonin may not be the only neurotransmitter active in the growth hormone response to 5-HTP.	5-Hydroxytryptophan	116-121	growth hormone 1	Homo sapiens	89-103
3496207-8	1987	Injections of alpha-methyl-para tyrosine, an inhibitor of tyrosine hydroxylase, and 5-hydroxytryptophan, a precursor of serotonin, caused 20- to 30-fold rises in plasma PRL levels in both LOBEX and SHAM rats.	5-Hydroxytryptophan	84-103	prolactin	Rattus norvegicus	169-172
3116560-8	1987	These data suggest that the 5-HT1B site mediates 5-HTP-evoked locomotor hyperactivity in the DHT model, that the 5-HT2 site participates in the transient hypoactivity seen with high doses of 5-HTP, and that 5-HT1 and 5-HT2 sites may be functionally linked.	5-Hydroxytryptophan	49-54	5-hydroxytryptamine receptor 1B	Rattus norvegicus	28-34
2437427-1	1987	To investigate the neurochemical mechanism of the response of growth hormone to 5-hydroxytryptophan (5-HTP), we administered 5-HTP (20 mg/kg) to 10 ovine fetuses (110 or 130 days old; term gestation 147 days).	5-Hydroxytryptophan	80-99	growth hormone 1	Homo sapiens	62-76
2435887-8	1987	In addition, the PRL response to 5-hydroxytryptophan was greatly potentiated, suggesting that functional supersensitivity developed in the 5,7-DHT-treated animals.	5-Hydroxytryptophan	33-52	prolactin	Rattus norvegicus	17-20
2437427-1	1987	To investigate the neurochemical mechanism of the response of growth hormone to 5-hydroxytryptophan (5-HTP), we administered 5-HTP (20 mg/kg) to 10 ovine fetuses (110 or 130 days old; term gestation 147 days).	5-Hydroxytryptophan	101-106	growth hormone 1	Homo sapiens	62-76
3496316-4	1987	Ten minutes after 5-HTP treatment a decrease was found in all parameter tests, except in IL-3 and in CSF secretion.	5-Hydroxytryptophan	18-23	interleukin 3	Homo sapiens	89-93
3496316-4	1987	Ten minutes after 5-HTP treatment a decrease was found in all parameter tests, except in IL-3 and in CSF secretion.	5-Hydroxytryptophan	18-23	colony stimulating factor 2	Homo sapiens	101-104
3542515-9	1987	The stimulatory effect on plasma PRL in sham and intact rats by one iv bolus injection of the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP; 10 mg/kg BW) was completely abolished in PVL animals (basal to peak: PVL, 3.7 +/- 0.6 to 5.2 +/- 1.4; sham, 6.7 +/- 0.6 to 36.0 +/- 0.5; intact, 4.1 +/- 1.2 to 33.3 +/- 3.2).	5-Hydroxytryptophan	114-136	prolactin	Rattus norvegicus	33-36
3497800-3	1987	In contrast, chronic treatment of rats with dexamethasone resulted in a potentiation of the PRL response to quipazine, 5-hydroxytryptophan and haloperidol.	5-Hydroxytryptophan	119-138	prolactin	Rattus norvegicus	92-95
3031276-5	1987	The PRL response to the serotonin precursor 5-hydroxytryptophan was potentiated by fluoxetine only in animals 15 days of age or older.	5-Hydroxytryptophan	44-63	prolactin	Rattus norvegicus	4-7
3031276-7	1987	Unlike PRL, corticosterone and growth hormone secretion were stimulated by quipazine and 5-hydroxytryptophan plus fluoxetine in both adult and neonatal rats.	5-Hydroxytryptophan	89-108	gonadotropin releasing hormone receptor	Rattus norvegicus	31-45
3497800-1	1987	Basal serum concentrations of prolactin (PRL) and the elevation of serum PRL concentrations induced by the serotonergic agents, quipazine and 5-hydroxytryptophan (5-HTP) were suppressed in rats treated acutely with dexamethasone.	5-Hydroxytryptophan	142-161	prolactin	Rattus norvegicus	73-76
3497800-1	1987	Basal serum concentrations of prolactin (PRL) and the elevation of serum PRL concentrations induced by the serotonergic agents, quipazine and 5-hydroxytryptophan (5-HTP) were suppressed in rats treated acutely with dexamethasone.	5-Hydroxytryptophan	163-168	prolactin	Rattus norvegicus	73-76
2435178-1	1987	To determine if the enhanced cortisol response to oral administration of the serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) that has been reported in unmedicated depressed and manic patients might be related to brain monoaminergic metabolism, the authors assessed correlations between 5-HTP-induced cortisol response and CSF in nine depressed patients.	5-Hydroxytryptophan	104-123	colony stimulating factor 2	Homo sapiens	329-332
2435178-1	1987	To determine if the enhanced cortisol response to oral administration of the serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) that has been reported in unmedicated depressed and manic patients might be related to brain monoaminergic metabolism, the authors assessed correlations between 5-HTP-induced cortisol response and CSF in nine depressed patients.	5-Hydroxytryptophan	125-130	colony stimulating factor 2	Homo sapiens	329-332
2882790-4	1987	Interestingly, the output of VP was stimulated by local activation of probable 5-hydroxytryptamine (5-HT) terminals with 5-hydroxytryptophan (5-HTP), a precursor of 5-HT synthesis.	5-Hydroxytryptophan	121-140	arginine vasopressin	Rattus norvegicus	29-31
2882790-4	1987	Interestingly, the output of VP was stimulated by local activation of probable 5-hydroxytryptamine (5-HT) terminals with 5-hydroxytryptophan (5-HTP), a precursor of 5-HT synthesis.	5-Hydroxytryptophan	142-147	arginine vasopressin	Rattus norvegicus	29-31
2886396-5	1987	The TRH (4 micrograms/kg) decreased 5-hydroxytryptophan and 3,4-dihydroxyphenylalanine accumulation after 10 min, and no effect on serotonin and noradrenaline concentrations was observed.	5-Hydroxytryptophan	36-55	thyrotropin releasing hormone	Rattus norvegicus	4-7
2945645-0	1986	Effects of L-5HTP with and without carbidopa on plasma beta-endorphin and pain perception: possible implications in migraine prophylaxis.	5-Hydroxytryptophan	11-17	proopiomelanocortin	Homo sapiens	55-69
3114804-0	1987	Effect of the selective 5-HT3 receptor antagonists ICS 205-930 and MDL 72222 on 5-HTP-induced head shaking and behavioral symptoms induced by 5-methoxy-N,N,dimethyltryptamine in rats: comparison with some other 5-HT receptor antagonists.	5-Hydroxytryptophan	80-85	5-hydroxytryptamine receptor 3A	Rattus norvegicus	24-38
3566833-1	1986	In psychopharmacological tests in rats and mice, 4-(5-chloro-benzofuranyl-2)-1-methylpiperidine HC1 (CGP 4718 A) was found to exert behavioral effects typical of both monoamine oxidase (MAO)-A and 5-hydroxytryptamine (5-HT) uptake inhibitors (reserpine antagonism, L-5-HTP potentiation, antiaggressive activity in isolated mice).	5-Hydroxytryptophan	265-272	heterochromatin, Chr 1	Mus musculus	96-99
2946344-10	1986	Chronic treatment with 8-OH-DPAT (5 mg kg-1, s.c.) produced a modest enhancement of the 5-HT2 receptor-mediated head-twitch behaviour initiated by 5-hydroxytryptophan injection while chronic isapirone decreased this behavioural response.	5-Hydroxytryptophan	147-166	hypothermia due to alcohol sensitivity 2	Mus musculus	90-93
3534635-0	1986	Adenosine deaminase-containing hypothalamic neurons accumulate 5-hydroxytryptophan: a dual-colour immunofluorescence procedure using a new fluorescence marker.	5-Hydroxytryptophan	63-82	adenosine deaminase	Rattus norvegicus	0-19
3089763-3	1986	Injection of rabbit antiserum specific for rat GRF (0.5 ml/rat, iv, 30 min previously) blunted the plasma GH increase induced by 5-hydroxy-L-tryptophan or serotonin in these animals.	5-Hydroxytryptophan	129-151	growth hormone releasing hormone	Rattus norvegicus	47-50
2948652-0	1986	Effects of L-5HTP with and without carbidopa on plasma beta-endorphin and pain perception.	5-Hydroxytryptophan	11-17	proopiomelanocortin	Homo sapiens	55-69
2948652-4	1986	In this study the effects of subchronic administration of L-5-hydroxy-tryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers.	5-Hydroxytryptophan	58-80	proopiomelanocortin	Homo sapiens	129-143
2948652-4	1986	In this study the effects of subchronic administration of L-5-hydroxy-tryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers.	5-Hydroxytryptophan	58-80	proopiomelanocortin	Homo sapiens	145-152
2948652-4	1986	In this study the effects of subchronic administration of L-5-hydroxy-tryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers.	5-Hydroxytryptophan	82-88	proopiomelanocortin	Homo sapiens	129-143
2948652-4	1986	In this study the effects of subchronic administration of L-5-hydroxy-tryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers.	5-Hydroxytryptophan	82-88	proopiomelanocortin	Homo sapiens	145-152
2948652-6	1986	L-5HTP treatment with and without carbidopa administration increased beta-EP levels significantly (p less than 0.05).	5-Hydroxytryptophan	0-6	proopiomelanocortin	Homo sapiens	69-76
2948652-7	1986	L-5HTP plus carbidopa induced an increase in beta-EP significantly (p less than 0.05) higher than that after L-5HTP alone.	5-Hydroxytryptophan	0-6	proopiomelanocortin	Homo sapiens	45-52
2948652-7	1986	L-5HTP plus carbidopa induced an increase in beta-EP significantly (p less than 0.05) higher than that after L-5HTP alone.	5-Hydroxytryptophan	109-115	proopiomelanocortin	Homo sapiens	45-52
2429741-7	1986	Approximately 20% of ADA-immunoreactive neurons represented nearly all cells having 5-HTP uptake capability.	5-Hydroxytryptophan	84-89	adenosine deaminase	Rattus norvegicus	21-24
2945645-3	1986	In this study the effects of subchronic administration of L-5-hydroxytryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers.	5-Hydroxytryptophan	58-79	proopiomelanocortin	Homo sapiens	128-142
2945645-3	1986	In this study the effects of subchronic administration of L-5-hydroxytryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers.	5-Hydroxytryptophan	58-79	proopiomelanocortin	Homo sapiens	144-151
3489504-9	1986	The combination of fluoxetine and 5-hydroxytryptophan (FLX/5-HTP) caused an initial increase in prolactin secretion with plasma values returning to basal levels by 4 h. When rats were pretreated with FLX/5-HTP instead of morphine, the prolactin response to an injection of morphine 4 h later was not attenuated.	5-Hydroxytryptophan	34-53	prolactin	Rattus norvegicus	96-105
2945645-3	1986	In this study the effects of subchronic administration of L-5-hydroxytryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers.	5-Hydroxytryptophan	81-87	proopiomelanocortin	Homo sapiens	128-142
3489504-9	1986	The combination of fluoxetine and 5-hydroxytryptophan (FLX/5-HTP) caused an initial increase in prolactin secretion with plasma values returning to basal levels by 4 h. When rats were pretreated with FLX/5-HTP instead of morphine, the prolactin response to an injection of morphine 4 h later was not attenuated.	5-Hydroxytryptophan	34-53	prolactin	Rattus norvegicus	235-244
2945645-3	1986	In this study the effects of subchronic administration of L-5-hydroxytryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers.	5-Hydroxytryptophan	81-87	proopiomelanocortin	Homo sapiens	144-151
3489504-9	1986	The combination of fluoxetine and 5-hydroxytryptophan (FLX/5-HTP) caused an initial increase in prolactin secretion with plasma values returning to basal levels by 4 h. When rats were pretreated with FLX/5-HTP instead of morphine, the prolactin response to an injection of morphine 4 h later was not attenuated.	5-Hydroxytryptophan	59-64	prolactin	Rattus norvegicus	96-105
2945645-5	1986	L-5HTP treatment with and without carbidopa administration increased beta-EP levels significantly (p less than 0.05).	5-Hydroxytryptophan	0-6	proopiomelanocortin	Homo sapiens	69-76
3489504-9	1986	The combination of fluoxetine and 5-hydroxytryptophan (FLX/5-HTP) caused an initial increase in prolactin secretion with plasma values returning to basal levels by 4 h. When rats were pretreated with FLX/5-HTP instead of morphine, the prolactin response to an injection of morphine 4 h later was not attenuated.	5-Hydroxytryptophan	59-64	prolactin	Rattus norvegicus	235-244
2945645-6	1986	L-5HTP plus carbidopa induced an increase in beta-EP significantly (p less than 0.05) greater than that induced by L-5HTP alone.	5-Hydroxytryptophan	0-6	proopiomelanocortin	Homo sapiens	45-52
2945645-6	1986	L-5HTP plus carbidopa induced an increase in beta-EP significantly (p less than 0.05) greater than that induced by L-5HTP alone.	5-Hydroxytryptophan	115-121	proopiomelanocortin	Homo sapiens	45-52
3490854-5	1986	PIR also facilitated the effect of L-dopa and L-5-HTP on the hind limb flexor reflex of the spinal rat.	5-Hydroxytryptophan	46-53	pirin	Rattus norvegicus	0-3
3484903-2	1986	This study was performed (1) to determine the minimal dose of 5-hydroxytryptophan that would produce a consistent and significant prolactin increase and (2) to establish the frequency of 5-hydroxytryptophan administration necessary to induce a persistent prolactin increase.	5-Hydroxytryptophan	187-206	prolactin	Homo sapiens	255-264
3484903-0	1986	Influence of sequential doses of 5-hydroxytryptophan on prolactin release.	5-Hydroxytryptophan	33-52	prolactin	Homo sapiens	56-65
3484903-2	1986	This study was performed (1) to determine the minimal dose of 5-hydroxytryptophan that would produce a consistent and significant prolactin increase and (2) to establish the frequency of 5-hydroxytryptophan administration necessary to induce a persistent prolactin increase.	5-Hydroxytryptophan	62-81	prolactin	Homo sapiens	130-139
2423604-6	1986	The concentration of 5-HTP producing the half-maximal effect = 4 X 10(-7) M. 5-HT suppression of IFN-gamma-induced Ia expression was antagonized by the 5-HT2 type receptor antagonists spiperone, ketanserin, and LY53857.	5-Hydroxytryptophan	21-26	interferon gamma	Mus musculus	97-106
3485291-1	1986	Intracerebroventricular (icv) injection of neurotensin (NT) (2 micrograms/rat) suppressed prolactin (PRL) release induced by L-5-hydroxytryptophan (1 mg/100 g body wt, iv), prostaglandin E2(1 microgram/rat, icv), and FK33-824 (10 micrograms/100 g body wt, iv), a Met5-enkephalin analog, in urethane-anesthetized or conscious rats.	5-Hydroxytryptophan	125-146	neurotensin	Rattus norvegicus	43-54
3485291-1	1986	Intracerebroventricular (icv) injection of neurotensin (NT) (2 micrograms/rat) suppressed prolactin (PRL) release induced by L-5-hydroxytryptophan (1 mg/100 g body wt, iv), prostaglandin E2(1 microgram/rat, icv), and FK33-824 (10 micrograms/100 g body wt, iv), a Met5-enkephalin analog, in urethane-anesthetized or conscious rats.	5-Hydroxytryptophan	125-146	prolactin	Rattus norvegicus	90-99
3485291-1	1986	Intracerebroventricular (icv) injection of neurotensin (NT) (2 micrograms/rat) suppressed prolactin (PRL) release induced by L-5-hydroxytryptophan (1 mg/100 g body wt, iv), prostaglandin E2(1 microgram/rat, icv), and FK33-824 (10 micrograms/100 g body wt, iv), a Met5-enkephalin analog, in urethane-anesthetized or conscious rats.	5-Hydroxytryptophan	125-146	prolactin	Rattus norvegicus	101-104
3484903-2	1986	This study was performed (1) to determine the minimal dose of 5-hydroxytryptophan that would produce a consistent and significant prolactin increase and (2) to establish the frequency of 5-hydroxytryptophan administration necessary to induce a persistent prolactin increase.	5-Hydroxytryptophan	62-81	prolactin	Homo sapiens	255-264
3484903-6	1986	5-Hydroxytryptophan at a dosage of 0.4 mg/kg/hr was the minimal amount to elicit a consistent and significant prolactin increase (p less than 0.01).	5-Hydroxytryptophan	0-19	prolactin	Homo sapiens	110-119
3484903-9	1986	With exception of the 12-hour interval a significantly smaller plasma prolactin increase was seen following the third dose of 5-hydroxytryptophan (p less than 0.05).	5-Hydroxytryptophan	126-145	prolactin	Homo sapiens	70-79
3484903-12	1986	In conclusion, this study has demonstrated a dose-related prolactin response to increasing doses of 5-hydroxytryptophan.	5-Hydroxytryptophan	100-119	prolactin	Homo sapiens	58-67
3484903-13	1986	The maximum down regulation of prolactin release occurred when 5-hydroxytryptophan was administered at 4-hour intervals.	5-Hydroxytryptophan	63-82	prolactin	Homo sapiens	31-40
2415092-6	1985	A compound behaving like partially oxidized 5-HTP was also observed in DAT CSF.	5-Hydroxytryptophan	44-49	solute carrier family 6 member 3	Homo sapiens	71-74
3002767-8	1986	Indirect stimulation of 5-HT neurons by administration of the amino acid precursor of 5-HT, 5-hydroxytryptophan, resulted in decreased DA synthesis in the ME of infantile animals and increased plasma PRL levels in that age group, indicating that this portion of the neurochemical connection is already present in infantile animals.	5-Hydroxytryptophan	92-111	prolactin	Rattus norvegicus	200-203
3002767-9	1986	Furthermore, the 5-hydroxytryptophan-induced increase in PRL was blocked by pretreatment with naloxone.	5-Hydroxytryptophan	17-36	prolactin	Rattus norvegicus	57-60
2870532-2	1986	All four agonists, dobutamine and prenalterol (beta 1-), and salbutamol and procaterol (beta 2-), potentiated the effect of L-5-HTP although they were ineffective in inducing the head-twitch when administered alone.	5-Hydroxytryptophan	124-131	hemoglobin, beta adult minor chain	Mus musculus	88-94
2415092-7	1985	Concentrations of 5-HTP, 5-HT, and 5-HIAA were lower in DAT CSF than in a corresponding fraction of control CSF.	5-Hydroxytryptophan	18-23	solute carrier family 6 member 3	Homo sapiens	56-59
2993947-5	1985	Administration of cholecystokinin against a background of phenamine and 5-hydroxy-tryptophan briefly entirely inhibited the behavioral effects induced by these substances.	5-Hydroxytryptophan	72-92	cholecystokinin	Rattus norvegicus	18-33
4091266-3	1985	Purified AADC showed a single band with an Mr of 50,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and decarboxylated L-3,4-dihydroxyphenylalanine, L-5-hydroxytryptophan, and L-threo-3,4-dihydroxyphenylserine (a synthetic precursor of natural norepinephrine).	5-Hydroxytryptophan	167-188	dopa decarboxylase	Homo sapiens	9-13
3876209-1	1985	The present study was aimed to clarify, by use of the passive immunization method, the involvement of endogenous vasoactive intestinal polypeptide (VIP) and peptide histidine isoleucine amide (PHI)-like peptides in the stimulation of PRL-like immunoreactive material release induced by 5-hydroxy-L-tryptophan (5HTP), a serotonin precursor.	5-Hydroxytryptophan	286-308	vasoactive intestinal peptide	Rattus norvegicus	113-146
3876209-1	1985	The present study was aimed to clarify, by use of the passive immunization method, the involvement of endogenous vasoactive intestinal polypeptide (VIP) and peptide histidine isoleucine amide (PHI)-like peptides in the stimulation of PRL-like immunoreactive material release induced by 5-hydroxy-L-tryptophan (5HTP), a serotonin precursor.	5-Hydroxytryptophan	310-314	vasoactive intestinal peptide	Rattus norvegicus	113-146
3876209-11	1985	These results suggest that endogenous VIP and PHI-like peptides are PRL-releasing factors, involved at least in the mechanism of 5HTP-induced PRL release, in which the dopaminergic control may be also involved.	5-Hydroxytryptophan	129-133	vasoactive intestinal peptide	Rattus norvegicus	38-41
6099203-7	1984	In both experimental models, a PRL secretagogue, e.g. 5-hydroxytryptophan (50 mg/kg i.p.	5-Hydroxytryptophan	54-73	prolactin	Rattus norvegicus	31-34
3875109-2	1985	The motor syndrome induced by L-5-HTP in rats is a simple test, allowing the identification of inhibitors of the 5-HT reuptake system and MAO-A.	5-Hydroxytryptophan	30-37	monoamine oxidase A	Rattus norvegicus	138-141
3872804-3	1985	injection of 5-hydroxytryptophan (5HTP), a precursor of 5HT, raised plasma prolactin (PRL) levels in urethane-anesthetized rats pretreated with normal rabbit serum.	5-Hydroxytryptophan	13-32	prolactin	Rattus norvegicus	75-84
3872804-3	1985	injection of 5-hydroxytryptophan (5HTP), a precursor of 5HT, raised plasma prolactin (PRL) levels in urethane-anesthetized rats pretreated with normal rabbit serum.	5-Hydroxytryptophan	13-32	prolactin	Rattus norvegicus	86-89
3872804-3	1985	injection of 5-hydroxytryptophan (5HTP), a precursor of 5HT, raised plasma prolactin (PRL) levels in urethane-anesthetized rats pretreated with normal rabbit serum.	5-Hydroxytryptophan	34-38	prolactin	Rattus norvegicus	75-84
3872804-3	1985	injection of 5-hydroxytryptophan (5HTP), a precursor of 5HT, raised plasma prolactin (PRL) levels in urethane-anesthetized rats pretreated with normal rabbit serum.	5-Hydroxytryptophan	34-38	prolactin	Rattus norvegicus	86-89
3872804-6	1985	with specific anti-VIP rabbit serum, the plasma PRL responses to 5HT and 5HTP were blunted.	5-Hydroxytryptophan	73-77	vasoactive intestinal peptide	Rattus norvegicus	19-22
3872804-6	1985	with specific anti-VIP rabbit serum, the plasma PRL responses to 5HT and 5HTP were blunted.	5-Hydroxytryptophan	73-77	prolactin	Rattus norvegicus	48-51
6150877-7	1984	5-HTP (20 mg/kg), the immediate serotonin precursor, increased both percentage PRL release and total PRL levels during subsequent incubation.	5-Hydroxytryptophan	0-5	prolactin	Oncorhynchus mykiss	79-82
6150877-7	1984	5-HTP (20 mg/kg), the immediate serotonin precursor, increased both percentage PRL release and total PRL levels during subsequent incubation.	5-Hydroxytryptophan	0-5	prolactin	Oncorhynchus mykiss	101-104
6375231-1	1984	We have previously shown that L-5-hydroxytryptophan (L-5-HTP) potentiates glucose-induced insulin release in islets isolated from ob/ob-mice.	5-Hydroxytryptophan	30-51	kinocilin	Mus musculus	53-60
6334429-1	1984	The concentration of L-5-hydroxytryptophan (5-HTP) was measured in plasma and whole brain tissue from mice by use of high pressure liquid chromatography with fluorimetric detection after reaction with phthaldialdehyde.	5-Hydroxytryptophan	44-49	kinocilin	Mus musculus	21-24
6205316-3	1984	It has been assumed, based on indirect evidence, that aromatic L-amino acid decarboxylase (L-AAD), the enzyme responsible for the conversion of L-5-hydroxytryptophan (5-HTP) to 5-HT as well as L-3,4-dihydroxyphenylalanine (L-dopa) to dopamine (DA), is ubiquitously distributed in most tissues of the body including the AP.	5-Hydroxytryptophan	144-165	dopa decarboxylase	Rattus norvegicus	54-89
6205316-3	1984	It has been assumed, based on indirect evidence, that aromatic L-amino acid decarboxylase (L-AAD), the enzyme responsible for the conversion of L-5-hydroxytryptophan (5-HTP) to 5-HT as well as L-3,4-dihydroxyphenylalanine (L-dopa) to dopamine (DA), is ubiquitously distributed in most tissues of the body including the AP.	5-Hydroxytryptophan	167-172	dopa decarboxylase	Rattus norvegicus	54-89
6468591-0	1984	Inhibition of pig kidney dopa decarboxylase by coenzyme-5-hydroxytryptophan adducts.	5-Hydroxytryptophan	58-75	dopa decarboxylase	Sus scrofa	25-43
6468591-2	1984	The different degree of inhibition exerted by these adducts has been interpreted on the basis of a different orientation of the 2 isomers of 5-HTP at the active of Dopa decarboxylase.	5-Hydroxytryptophan	141-146	dopa decarboxylase	Sus scrofa	164-182
6333583-4	1984	After this treatment AADC activities could be detected in the monkey serum by using both L-DOPA and L-5-HTP as substrates.	5-Hydroxytryptophan	100-107	dopa decarboxylase	Rattus norvegicus	21-25
6333583-6	1984	Serum AADC was partially purified from monkey and compared with that of rat using both L-DOPA and L-5-HTP as substrates, but the ratio of the activities for the two substrates did not change significantly in each fraction during purification from either monkey or rat serum.	5-Hydroxytryptophan	98-105	dopa decarboxylase	Rattus norvegicus	6-10
6628538-4	1983	It had a weak ability to antagonize the PRL-releasing effect of the 5-HT precursor, 5-hydroxytryptophan.	5-Hydroxytryptophan	84-103	prolactin	Rattus norvegicus	40-43
6610456-1	1984	Electrolytic lesions of the medial (MR) or dorsal (DR) raphe nucleus significantly antagonized serum prolactin elevations produced by 5-hydroxytryptophan (5-HTP) in rats pretreated with fluoxetine or citalopram, (serotonin (5-HT) uptake blockers).	5-Hydroxytryptophan	134-153	prolactin	Rattus norvegicus	101-110
6610456-1	1984	Electrolytic lesions of the medial (MR) or dorsal (DR) raphe nucleus significantly antagonized serum prolactin elevations produced by 5-hydroxytryptophan (5-HTP) in rats pretreated with fluoxetine or citalopram, (serotonin (5-HT) uptake blockers).	5-Hydroxytryptophan	155-160	prolactin	Rattus norvegicus	101-110
6141712-5	1984	Changes in AADC with L-DOPA or L-5-HTP as substrates varied in parkinsonian brains.	5-Hydroxytryptophan	31-38	dopa decarboxylase	Homo sapiens	11-15
6356172-1	1983	Subcutaneous administration of l-5-hydroxytryptophan (5-HTP), the precursor of serotonin, to female rats induces copious drinking accompanied by activation of the renin-angiotensin system.	5-Hydroxytryptophan	31-52	renin	Rattus norvegicus	163-168
6356172-1	1983	Subcutaneous administration of l-5-hydroxytryptophan (5-HTP), the precursor of serotonin, to female rats induces copious drinking accompanied by activation of the renin-angiotensin system.	5-Hydroxytryptophan	54-59	renin	Rattus norvegicus	163-168
6430673-10	1984	In 5-hydroxytryptophan pretreated group the stimulatory effect of VIP on TSH release was prevented, but not in that pretreated with para-chlorophenylalanine, L-DOPA or haloperidol.	5-Hydroxytryptophan	3-22	vasoactive intestinal peptide	Rattus norvegicus	66-69
6230284-3	1983	The 5-HT precursor, 5-hydroxytryptophan (5-HTP), at doses of 80 and 150 mg/kg produced over a twofold elevation in PRL level 1 hr after administration, though the 50 mg/kg dose failed to produce any change.	5-Hydroxytryptophan	20-39	prolactin	Meleagris gallopavo	115-118
6230284-3	1983	The 5-HT precursor, 5-hydroxytryptophan (5-HTP), at doses of 80 and 150 mg/kg produced over a twofold elevation in PRL level 1 hr after administration, though the 50 mg/kg dose failed to produce any change.	5-Hydroxytryptophan	41-46	prolactin	Meleagris gallopavo	115-118
6230284-5	1983	When fluoxetine injection preceded administration of a weakly stimulatory dose of 5-HTP, a prolonged elevation in PRL level was observed.	5-Hydroxytryptophan	82-87	prolactin	Meleagris gallopavo	114-117
6230284-7	1983	Prior injection of 20 mg/kg MES completely blocked the serum PRL rises induced by quipazine and 5-HTP.	5-Hydroxytryptophan	96-101	prolactin	Meleagris gallopavo	61-64
6983619-0	1982	Effect of pyridoxal phosphate deficiency on aromatic L-amino acid decarboxylase activity with L-DOPA and L-5-hydroxytryptophan as substrates in rats.	5-Hydroxytryptophan	105-126	dopa decarboxylase	Rattus norvegicus	53-79
6401334-8	1983	APO, RDS-127 and JMC-181 were active in inhibiting the accumulation of dopa in the caudate nucleus and olfactory tubercle using the in vivo gamma-butyrolactone procedure; 5-hydroxytryptophan accumulations were not altered significantly.	5-Hydroxytryptophan	171-190	peripherin 2	Rattus norvegicus	5-8
6983619-1	1982	This paper describes the distribution of aromatic L-amino acid decarboxylase (AADC) activities in fourteen tissues (eight peripheral tissues and six brain regions) of semicarbazide (SC)-treated rats, using both L-DOPA and L-5-hydroxytryptophan (L-5-HTP) as substrates.	5-Hydroxytryptophan	222-243	dopa decarboxylase	Rattus norvegicus	78-82
6983619-1	1982	This paper describes the distribution of aromatic L-amino acid decarboxylase (AADC) activities in fourteen tissues (eight peripheral tissues and six brain regions) of semicarbazide (SC)-treated rats, using both L-DOPA and L-5-hydroxytryptophan (L-5-HTP) as substrates.	5-Hydroxytryptophan	245-252	dopa decarboxylase	Rattus norvegicus	78-82
6134546-7	1983	potentiated the PRL-releasing effect of 5-hydroxytryptophan (30 mg/kg i.p.).	5-Hydroxytryptophan	40-59	prolactin	Rattus norvegicus	16-19
6979001-4	1982	Diazepam administration also blunted the release of prolactin induced by dopaminergic receptor blockade following haloperidol, or by serotonergic receptor activation produced by fluoxetine, a serotonergic reuptake inhibitor plus 5-hydroxytryptophan, a serotonin precursor.	5-Hydroxytryptophan	229-248	prolactin	Rattus norvegicus	52-61
7173435-2	1982	Cholecystokinin suppressing markedly dopamine and serotonin turnover in various brain structures, completely blocked the behavioral effects of amphetamine (2.5 mg/kg) and 5-hydroxytryptophan (150 mg/kg).	5-Hydroxytryptophan	171-190	cholecystokinin	Rattus norvegicus	0-15
7084118-5	1982	Intravenous injection of L-5-hydroxytryptophan (5-HTP, 1 mg/100 g BW), a precursor of 5-HT, also caused an increase in VIP concentrations in hypophysial portal plasma.	5-Hydroxytryptophan	25-46	vasoactive intestinal peptide	Rattus norvegicus	119-122
7084118-5	1982	Intravenous injection of L-5-hydroxytryptophan (5-HTP, 1 mg/100 g BW), a precursor of 5-HT, also caused an increase in VIP concentrations in hypophysial portal plasma.	5-Hydroxytryptophan	48-53	vasoactive intestinal peptide	Rattus norvegicus	119-122
7070582-1	1982	H13/04, an audiogenic seizure-inducing catecholamide, has previously been demonstrated to decrease the accumulation of 5-hydroxytryptophan (5-HTP), while increasing the accumulation of dihydroxyphenylalanine (DOPA) after aromatic acid decarboxylase inhibition in vivo.	5-Hydroxytryptophan	119-138	histocompatibility 13	Mus musculus	0-6
7070582-1	1982	H13/04, an audiogenic seizure-inducing catecholamide, has previously been demonstrated to decrease the accumulation of 5-hydroxytryptophan (5-HTP), while increasing the accumulation of dihydroxyphenylalanine (DOPA) after aromatic acid decarboxylase inhibition in vivo.	5-Hydroxytryptophan	140-145	histocompatibility 13	Mus musculus	0-6
6983619-4	1982	AADC activities towards L-DOPA and L-5-HTP as substrates were also decreased significantly in almost all tissues of SC-treated rats.	5-Hydroxytryptophan	35-42	dopa decarboxylase	Rattus norvegicus	0-4
6983619-7	1982	Serum AADC activities were decreased drastically using both L-DOPA and L-5-HTP as substrates.	5-Hydroxytryptophan	71-78	dopa decarboxylase	Rattus norvegicus	6-10
6276803-0	1982	Evidence that the effects of 5-hydroxytryptophan on the secretion of ACTH and growth hormone in dogs are not mediated by central release of serotonin.	5-Hydroxytryptophan	29-48	proopiomelanocortin	Canis lupus familiaris	69-73
6276803-0	1982	Evidence that the effects of 5-hydroxytryptophan on the secretion of ACTH and growth hormone in dogs are not mediated by central release of serotonin.	5-Hydroxytryptophan	29-48	somatotropin	Canis lupus familiaris	78-92
6276803-1	1982	5-Hydroxytryptophan (5-HTP) was found to lower plasma 11-oxycorticoids and increase plasma growth hormone in anesthetized dogs.	5-Hydroxytryptophan	0-19	somatotropin	Canis lupus familiaris	91-105
6276803-1	1982	5-Hydroxytryptophan (5-HTP) was found to lower plasma 11-oxycorticoids and increase plasma growth hormone in anesthetized dogs.	5-Hydroxytryptophan	21-26	somatotropin	Canis lupus familiaris	91-105
6276803-6	1982	The increase in plasma growth hormone produced by 5-HTP was potentiated by carbidopa and abolished by benserazide.	5-Hydroxytryptophan	50-55	somatotropin	Canis lupus familiaris	23-37
6276803-9	1982	The data indicate that the effects of 5-HTP on ACTH and growth hormone secretion are not due to central release of serotonin and suggest that they are due instead to serotonin-induced release of catecholamines from catecholamine-secreting neurons.	5-Hydroxytryptophan	38-43	proopiomelanocortin	Canis lupus familiaris	47-51
6276803-9	1982	The data indicate that the effects of 5-HTP on ACTH and growth hormone secretion are not due to central release of serotonin and suggest that they are due instead to serotonin-induced release of catecholamines from catecholamine-secreting neurons.	5-Hydroxytryptophan	38-43	somatotropin	Canis lupus familiaris	56-70
6457138-3	1981	p-Chlorophenylalanine decreased plasma renin activity and p-chlorophenylalanine plus 5-hydroxytryptophan increased plasma renin activity.	5-Hydroxytryptophan	85-104	renin	Rattus norvegicus	122-127
20487843-0	1982	Demonstration of aromatic l-amino acid decarboxylase activity in human brain with l-dopa and l-5-hydroxytryptophan as substrates by high-performance liquid chromatography with electrochemical detection.	5-Hydroxytryptophan	93-114	dopa decarboxylase	Homo sapiens	17-52
20487843-1	1982	The enzymatic decarboxylations of l-DOPA and l-5-hydroxytryptophan (l-5-HTP) by aromatic l-amino acid decarboxylase (AADC) were measured with homogenates from human brain regions, caduate nucleus and hypothalamus, using our new and highly sensitive methods for l-DOPA decarboxylase and l-5-HTP decarboxylase by high-performance liquid chromatography with electrochemical detection (HPLC-ED).	5-Hydroxytryptophan	45-66	dopa decarboxylase	Homo sapiens	89-115
20487843-1	1982	The enzymatic decarboxylations of l-DOPA and l-5-hydroxytryptophan (l-5-HTP) by aromatic l-amino acid decarboxylase (AADC) were measured with homogenates from human brain regions, caduate nucleus and hypothalamus, using our new and highly sensitive methods for l-DOPA decarboxylase and l-5-HTP decarboxylase by high-performance liquid chromatography with electrochemical detection (HPLC-ED).	5-Hydroxytryptophan	45-66	dopa decarboxylase	Homo sapiens	117-121
20487843-1	1982	The enzymatic decarboxylations of l-DOPA and l-5-hydroxytryptophan (l-5-HTP) by aromatic l-amino acid decarboxylase (AADC) were measured with homogenates from human brain regions, caduate nucleus and hypothalamus, using our new and highly sensitive methods for l-DOPA decarboxylase and l-5-HTP decarboxylase by high-performance liquid chromatography with electrochemical detection (HPLC-ED).	5-Hydroxytryptophan	68-75	dopa decarboxylase	Homo sapiens	89-115
20487843-1	1982	The enzymatic decarboxylations of l-DOPA and l-5-hydroxytryptophan (l-5-HTP) by aromatic l-amino acid decarboxylase (AADC) were measured with homogenates from human brain regions, caduate nucleus and hypothalamus, using our new and highly sensitive methods for l-DOPA decarboxylase and l-5-HTP decarboxylase by high-performance liquid chromatography with electrochemical detection (HPLC-ED).	5-Hydroxytryptophan	68-75	dopa decarboxylase	Homo sapiens	117-121
20487843-1	1982	The enzymatic decarboxylations of l-DOPA and l-5-hydroxytryptophan (l-5-HTP) by aromatic l-amino acid decarboxylase (AADC) were measured with homogenates from human brain regions, caduate nucleus and hypothalamus, using our new and highly sensitive methods for l-DOPA decarboxylase and l-5-HTP decarboxylase by high-performance liquid chromatography with electrochemical detection (HPLC-ED).	5-Hydroxytryptophan	68-75	dopa decarboxylase	Homo sapiens	263-281
20487843-6	1982	AADC activities in human brains were found to be widely variable for both l-DOPA and l-5-HTP as substrates.	5-Hydroxytryptophan	85-92	dopa decarboxylase	Homo sapiens	0-4
6985126-0	1981	The effect of DL-5-hydroxytryptophan (5-HTP) on plasma prolactin in pituitary stalk sectioned rats.	5-Hydroxytryptophan	38-43	prolactin	Rattus norvegicus	55-64
6974213-4	1981	Administration of 5-hydroxytryptophan led to a rise in plasma prolactin and a drop in plasma GH levels in untreated birds or in animals pretreated with pCPA.	5-Hydroxytryptophan	18-37	prolactin	Homo sapiens	62-71
6175178-1	1981	Single oral doses of L-5-hydroxytryptophan (5-HTP) were administered in combination with L-aromatic amino acid decarboxylase inhibitors.	5-Hydroxytryptophan	44-49	ribosomal protein L5	Homo sapiens	21-24
6113187-1	1981	The rat stomach was shown some years ago to contain numerous endocrine cells with APUD ability--cells that could take up the amino acids L-5-hydroxytryptophan (5-HTP) or L-dihydroxyphenylalanine (L-DOPA) and could decarboxylate them to their respective amines, 5-hydroxytryptamine (5-HT, serotonin) and dopamine, by means of the enzyme DOPA-decarboxylase.	5-Hydroxytryptophan	137-158	dopa decarboxylase	Rattus norvegicus	336-354
6985126-0	1981	The effect of DL-5-hydroxytryptophan (5-HTP) on plasma prolactin in pituitary stalk sectioned rats.	5-Hydroxytryptophan	14-36	prolactin	Rattus norvegicus	55-64
6985126-2	1981	Plasma prolactin levels were initially increased 30 and 60 min after the injection of 5-HTP and thereafter decreased.	5-Hydroxytryptophan	86-91	prolactin	Rattus norvegicus	7-16
6113187-1	1981	The rat stomach was shown some years ago to contain numerous endocrine cells with APUD ability--cells that could take up the amino acids L-5-hydroxytryptophan (5-HTP) or L-dihydroxyphenylalanine (L-DOPA) and could decarboxylate them to their respective amines, 5-hydroxytryptamine (5-HT, serotonin) and dopamine, by means of the enzyme DOPA-decarboxylase.	5-Hydroxytryptophan	160-165	dopa decarboxylase	Rattus norvegicus	336-354
6985126-4	1981	The treatment of 5-HTP induced a moderate increase in pituitary prolactin content in the stalk sectioned rats.	5-Hydroxytryptophan	17-22	prolactin	Rattus norvegicus	64-73
6971560-2	1981	Chlorimipramine, citalopram, fluoxetine, imipramine and zimelidine potentiated the low dose 5-hydroxytryptophan (5-HTP)-induced increase in prolactin secretion, suggesting inhibition of serotonin (5-HT) uptake by these drugs.	5-Hydroxytryptophan	92-111	prolactin	Rattus norvegicus	140-149
6973156-3	1981	l-5-Hydroxytryptophan (5-HTP), the precursor of serotonin, is also a potent dipsogen which induces drinking by way of the renin-angiotensin system.	5-Hydroxytryptophan	0-21	renin	Rattus norvegicus	122-127
6973156-3	1981	l-5-Hydroxytryptophan (5-HTP), the precursor of serotonin, is also a potent dipsogen which induces drinking by way of the renin-angiotensin system.	5-Hydroxytryptophan	23-28	renin	Rattus norvegicus	122-127
7019933-0	1981	Effects of serotonin and L-5-hydroxytryptophan on plasma renin activity in rats.	5-Hydroxytryptophan	25-46	renin	Rattus norvegicus	57-62
7019933-8	1981	The mechanism by which activation of the renin-angiotensin system occurs following peripheral administration of either 5-HTP or serotonin remains for further study.	5-Hydroxytryptophan	119-124	renin	Rattus norvegicus	41-46
6783444-5	1981	Destruction of CA3-4 blocks the ability of Met-enkephalin, ketocyclazocine, and 5-hydroxytryptophan, but not sodium valproate or ice water to induce withdrawal-like behaviors.	5-Hydroxytryptophan	80-99	carbonic anhydrase 3	Rattus norvegicus	15-20
6167271-0	1981	Inverse relation of substance P-like immunoreactivity in dorsal raphe nucleus to serotonin levels in pons-medulla following administration of cocaine and 5-hydroxytryptophan.	5-Hydroxytryptophan	154-173	tachykinin precursor 1	Homo sapiens	20-31
6973044-1	1981	An intraperitoneal administration of large doses of L-5-hydroxytryptophan (L-5HTP) induced dose-dependently a behaviour characterized by backward walking in mice.	5-Hydroxytryptophan	75-81	kinocilin	Mus musculus	52-55
6971560-2	1981	Chlorimipramine, citalopram, fluoxetine, imipramine and zimelidine potentiated the low dose 5-hydroxytryptophan (5-HTP)-induced increase in prolactin secretion, suggesting inhibition of serotonin (5-HT) uptake by these drugs.	5-Hydroxytryptophan	113-118	prolactin	Rattus norvegicus	140-149
6971560-3	1981	Amitriptyline, doxepin, iprindole, mianserin and trazadone inhibited the prolactin stimulating effects of high doses of 5-HTP and quipazine, suggesting that these drugs have 5-HT receptor blocking properties.	5-Hydroxytryptophan	120-125	prolactin	Rattus norvegicus	73-82
6971560-4	1981	Tandamine inhibited only 5-HTP-induced increase in prolactin secretion.	5-Hydroxytryptophan	25-30	prolactin	Rattus norvegicus	51-60
6971560-6	1981	Amitriptyline, produced similar inhibition of the 5-HTP-induced increase in prolactin secretion after both acute and chronic administration.	5-Hydroxytryptophan	50-55	prolactin	Rattus norvegicus	76-85
6785814-2	1981	The 5-HTP-induced changes include elevation of serum prolactin, decrease in operant responding, and the magnitude of the "serotonin behavioral syndrome" observed after 5-HTP administration.	5-Hydroxytryptophan	4-9	prolactin	Rattus norvegicus	53-62
6115443-3	1981	Maximal behavioral supersensitivity to L-5-HTP and 5-MeODMT was found as early as 24 h after injection of the neurotoxin, even in the presence of the specific 5-HT uptake inhibitor CGP 6085 A, or the MAO-A inhibitor clorgyline.	5-Hydroxytryptophan	39-46	monoamine oxidase A	Rattus norvegicus	200-205
6966764-3	1980	The potentiation of the L-5-HTP syndrome by the MAO inhibitors correlated with the inhibition of the A- but not of the B-form of the brain monoamine oxidase.	5-Hydroxytryptophan	24-31	monoamine oxidase A	Rattus norvegicus	48-51
44325-7	1979	MAO inhibitor resulted in a vast accumulation of L-dopa: e.g. (1) L-5HTP was more slowly eliminated, and (2) 5-HT blockers produced a decreased content of 5-HT after injection of L-5HTP, in contrast to the finding that DA-blockers produced an incresed content of DA after injection of L-dopa.	5-Hydroxytryptophan	66-72	monoamine oxidase A	Rattus norvegicus	0-3
37141-1	1979	Rat gastric oxyntic glands contain argyrophil "enterochromaffin-like" endocrine cells that synthesize and store histamine and also have APUD ability--they can take up exogenous L-5-hydroxytryptophan (5-HTP), can decarboxylate it to 5-hydroxytryptamine (5-HT, serotonin) by the enzyme DOPA-decarboxylase, and can store the amine.	5-Hydroxytryptophan	177-198	dopa decarboxylase	Rattus norvegicus	284-302
6986577-3	1980	5-Hydroxytryptophan (5-HTP) caused a significant increase (p less than 0.05) in arterial plasma renin activity (pra) that was abolished when peripheral and central aromatic amino acid decarboxylase activities were inhibited by administration of benserazide, but not reduced when only the peripheral decarboxylase activities were inhibited by administration of carbidopa.	5-Hydroxytryptophan	0-19	renin	Canis lupus familiaris	96-101
6986577-3	1980	5-Hydroxytryptophan (5-HTP) caused a significant increase (p less than 0.05) in arterial plasma renin activity (pra) that was abolished when peripheral and central aromatic amino acid decarboxylase activities were inhibited by administration of benserazide, but not reduced when only the peripheral decarboxylase activities were inhibited by administration of carbidopa.	5-Hydroxytryptophan	21-26	renin	Canis lupus familiaris	96-101
6986577-4	1980	The serotonin receptor blocking drug metergoline also abolished the renin response to 5-HTP.	5-Hydroxytryptophan	86-91	renin	Canis lupus familiaris	68-73
6986577-9	1980	These data indicate that 5-HTP and L-Tryptophan act on the central nervous system to produce an increase in renin secretion that is mediated via the renal nerves and occurs without a concomitant increase in sympathetic output to the heart or blood vessels.	5-Hydroxytryptophan	25-30	renin	Canis lupus familiaris	108-113
315250-0	1979	Does the hypoglycaemic effect of 5-hydroxytryptophan involve insulin? [proceedings].	5-Hydroxytryptophan	33-52	insulin	Homo sapiens	61-69
44325-7	1979	MAO inhibitor resulted in a vast accumulation of L-dopa: e.g. (1) L-5HTP was more slowly eliminated, and (2) 5-HT blockers produced a decreased content of 5-HT after injection of L-5HTP, in contrast to the finding that DA-blockers produced an incresed content of DA after injection of L-dopa.	5-Hydroxytryptophan	179-185	monoamine oxidase A	Rattus norvegicus	0-3
115227-5	1979	Some compounds known to activate the GABA system, including some benzodiazepines and the GABA-transaminase inhibitor amino-oxyacetic acid, also reduced the symptoms, as did the serotonin precursor L-5HTP.	5-Hydroxytryptophan	197-203	4-aminobutyrate aminotransferase	Homo sapiens	89-106
313988-2	1979	Injection of 5-HTP induces a melanodisperson ; MSH cells are markedly stimulated :hormone synthesis (development of Golgi area and endoplasmic reticulum) and release (reduction of secretory granules) are observed.	5-Hydroxytryptophan	13-18	msh homeobox 2	Homo sapiens	47-50
41406-2	1979	Tyrosine hydroxylase and tryptophan hydroxylase activity was studied in different brain regions (hemispheres, striatum, midbrain and brainstem in vivo by measuring the accumulation of dihydroxyphenylalanine (Dopa) and 5-hydroxytryptophan (5-HTP) respectively, after inhibition of aromatic L-amino acid decarobyxlase with NSD 1015.	5-Hydroxytryptophan	218-237	tyrosine hydroxylase	Rattus norvegicus	0-20
41406-2	1979	Tyrosine hydroxylase and tryptophan hydroxylase activity was studied in different brain regions (hemispheres, striatum, midbrain and brainstem in vivo by measuring the accumulation of dihydroxyphenylalanine (Dopa) and 5-hydroxytryptophan (5-HTP) respectively, after inhibition of aromatic L-amino acid decarobyxlase with NSD 1015.	5-Hydroxytryptophan	239-244	tyrosine hydroxylase	Rattus norvegicus	0-20
114870-3	1979	Fluoxetine, a serotonin reuptake inhibitor, plus 5-hydroxytryptophan, the immediate precursor of serotonin, markedly stimulated both plasma PRL and plasma PRF-like activity.	5-Hydroxytryptophan	49-68	prolactin	Rattus norvegicus	140-143
308387-0	1978	Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine.	5-Hydroxytryptophan	38-57	prolactin	Rattus norvegicus	15-24
23503-1	1977	In 10 day-old female and male rats, administration of 5-hydroxytryptophan (5-HTP) induced a prompt elevation in plasma prolactin (Prl) and growth hormone (GH) levels.	5-Hydroxytryptophan	54-73	gonadotropin releasing hormone receptor	Rattus norvegicus	139-153
313797-0	1978	[Simultaneous improvement of mood and release of growth hormone by L-5-hydroxytryptophan (Ro 3-5940) in normal subjects (author"s transl)].	5-Hydroxytryptophan	67-88	growth hormone 1	Homo sapiens	49-63
740049-5	1978	[Gln4]-neurotensin (100-200 microgram) following inhibition of the aromatic L-amino acid decarboxylase, increased the accumulation of 5-hydroxytryptophan in all brain regions by 30-60%.	5-Hydroxytryptophan	134-153	neurotensin	Rattus norvegicus	7-18
150951-5	1978	As injections of 5-hydroxytryptophan stimulate PRL cells, these findings suggest that a serotoninergic system may participate in the regulation of PRL cell activity.	5-Hydroxytryptophan	17-36	prolactin	Homo sapiens	47-50
150951-5	1978	As injections of 5-hydroxytryptophan stimulate PRL cells, these findings suggest that a serotoninergic system may participate in the regulation of PRL cell activity.	5-Hydroxytryptophan	17-36	prolactin	Homo sapiens	147-150
401022-2	1977	A highly significant increase in serum prolactin levels was observed after ip injection of 30 mg/kg of 5-hydroxytryptophan (5-HTP) in male or female rats pretreated with 10 mg/kg (ip) of fluoxetine.	5-Hydroxytryptophan	103-122	prolactin	Rattus norvegicus	39-48
401022-2	1977	A highly significant increase in serum prolactin levels was observed after ip injection of 30 mg/kg of 5-hydroxytryptophan (5-HTP) in male or female rats pretreated with 10 mg/kg (ip) of fluoxetine.	5-Hydroxytryptophan	124-129	prolactin	Rattus norvegicus	39-48
401022-6	1977	The results of this study strengthen the idea that 5-HTP is acting via serotonin-containing neurons that influence anterior pituitary prolactin release, and that serotonin receptor activation leads to prolactin release.	5-Hydroxytryptophan	51-56	prolactin	Rattus norvegicus	134-143
23503-1	1977	In 10 day-old female and male rats, administration of 5-hydroxytryptophan (5-HTP) induced a prompt elevation in plasma prolactin (Prl) and growth hormone (GH) levels.	5-Hydroxytryptophan	75-80	gonadotropin releasing hormone receptor	Rattus norvegicus	139-153
185101-13	1976	Using this method, it found that LVP, AVP, norepinephrine (100 ng/ml200 ng/ml) and 5-hydroxytryptophane (1 mug/ml) had ACTH releasing activities but LH-RH, TRH, glucagon, dopamine, phentolamine, propranolol, haloperidol, prostaglandin E1 and indomethacin did not affect the release of ACTH.	5-Hydroxytryptophan	83-103	proopiomelanocortin	Homo sapiens	119-123
11370231-5	1976	Responses of the vas deferens to transmural stimulation are depressed by pretreatment of rats with p-chlorophenylalanine, and the depression is reversed by incubation in vitro with 5-hydroxytryptophan or serotonin.	5-Hydroxytryptophan	181-200	arginine vasopressin	Rattus norvegicus	17-20
24271411-3	1976	In the P2 fraction isolated from the rat, either 55 mM K(+), 0.10 mML-5-HTP, or 0.03 mMalpha-MMTA significantly increased the release of [(3)H]5-HT above control levels, regardless of which MAO inhibitor was present in the medium.	5-Hydroxytryptophan	69-75	monoamine oxidase A	Rattus norvegicus	190-193
1088127-0	1976	Effect of hypothalamic surgery on prolactin release induced by 5-hydroxytryptophan (5-HTP) in rats.	5-Hydroxytryptophan	63-82	prolactin	Rattus norvegicus	34-43
1088127-0	1976	Effect of hypothalamic surgery on prolactin release induced by 5-hydroxytryptophan (5-HTP) in rats.	5-Hydroxytryptophan	84-89	prolactin	Rattus norvegicus	34-43
1088127-1	1976	Intravenous injections of varying doses of 5-HTP (1, 3 and 5 mg/100 g body wt), a precursor of serotonin, caused a significant and dose-related increase in plasma prolactin concentrations in urethane-anesthetized rats.	5-Hydroxytryptophan	43-48	prolactin	Rattus norvegicus	163-172
1088127-2	1976	Increases in plasma prolactin concentrations caused by 5-HTP (1 mg/100 g body wt iv) were abolished by the concomitant administration of L-DOPA (2 mg/100 g body wt iv).	5-Hydroxytryptophan	55-60	prolactin	Rattus norvegicus	20-29
8734-1	1976	The audiogenic seizure-inducing drug H13/04 was found to elicit opposing effects on the in vivo accumulation of 5-HTP (5-hydroxytryptophan) and DOPA (3,4-dihydroxyphenylalanine) in the brain following inhibition of L-amino acid decarboxylase.	5-Hydroxytryptophan	112-117	histocompatibility 13	Mus musculus	37-43
8734-1	1976	The audiogenic seizure-inducing drug H13/04 was found to elicit opposing effects on the in vivo accumulation of 5-HTP (5-hydroxytryptophan) and DOPA (3,4-dihydroxyphenylalanine) in the brain following inhibition of L-amino acid decarboxylase.	5-Hydroxytryptophan	119-138	histocompatibility 13	Mus musculus	37-43
185101-13	1976	Using this method, it found that LVP, AVP, norepinephrine (100 ng/ml200 ng/ml) and 5-hydroxytryptophane (1 mug/ml) had ACTH releasing activities but LH-RH, TRH, glucagon, dopamine, phentolamine, propranolol, haloperidol, prostaglandin E1 and indomethacin did not affect the release of ACTH.	5-Hydroxytryptophan	83-103	proopiomelanocortin	Homo sapiens	285-289
1087913-1	1976	L-5-hydroxytryptophan (L-5-HTP), an immediate serotonin precursor, was given to the hospitalized depressed patients in an open clinical trial of the Phase 2 study for antidepressive effects of the agent.	5-Hydroxytryptophan	0-21	ribosomal protein L5	Homo sapiens	23-30
1088138-1	1976	L-5-hydroxytryptophan (L-5-HTP), and immediate serotonin precursor, was given to the hospitalized depressed patients in an open clinical trial of the Phase 2 study for antidepressive effects of the agent.	5-Hydroxytryptophan	0-21	ribosomal protein L5	Homo sapiens	23-30
803259-2	1975	The precursor of serotonin, 5-hydroxytryptophan(5-HTP), produced a significant rise in serum prolactin and TSH, whereas para chloroamphetamine, a depletor of serotonin, elicited a fall in serum prolactin and TSH.	5-Hydroxytryptophan	28-47	prolactin	Rattus norvegicus	93-102
126790-1	1975	The effect of L-5-hydroxytryptophan (L-5-HTP) against the depression of tumor-resisting power in host animal, which is induced by a whole body x-irradiation of 500 R, was studied.	5-Hydroxytryptophan	14-35	kinocilin	Mus musculus	37-44
1087036-0	1976	Effect of apomorphine plus 5-hydroxytryptophan on plasma prolactin levels in male rats.	5-Hydroxytryptophan	27-46	prolactin	Rattus norvegicus	57-66
1087036-2	1976	5-Hydroxytryptophan (5-HTP), 100 mg/kg, i.p., the precursor of serotonin, produced a 6-11 fold increase in plasma prolactin.	5-Hydroxytryptophan	0-19	prolactin	Rattus norvegicus	114-123
1087036-2	1976	5-Hydroxytryptophan (5-HTP), 100 mg/kg, i.p., the precursor of serotonin, produced a 6-11 fold increase in plasma prolactin.	5-Hydroxytryptophan	21-26	prolactin	Rattus norvegicus	114-123
1087036-4	1976	However, when apomorphine was given with or before 5-HTP, it nearly completely blocked the increase in prolactin produced by 5-htp.	5-Hydroxytryptophan	125-130	prolactin	Rattus norvegicus	103-112
803259-2	1975	The precursor of serotonin, 5-hydroxytryptophan(5-HTP), produced a significant rise in serum prolactin and TSH, whereas para chloroamphetamine, a depletor of serotonin, elicited a fall in serum prolactin and TSH.	5-Hydroxytryptophan	28-47	prolactin	Rattus norvegicus	194-203
803259-2	1975	The precursor of serotonin, 5-hydroxytryptophan(5-HTP), produced a significant rise in serum prolactin and TSH, whereas para chloroamphetamine, a depletor of serotonin, elicited a fall in serum prolactin and TSH.	5-Hydroxytryptophan	48-53	prolactin	Rattus norvegicus	93-102
803259-2	1975	The precursor of serotonin, 5-hydroxytryptophan(5-HTP), produced a significant rise in serum prolactin and TSH, whereas para chloroamphetamine, a depletor of serotonin, elicited a fall in serum prolactin and TSH.	5-Hydroxytryptophan	48-53	prolactin	Rattus norvegicus	194-203
803259-4	1975	Injection of alpha-MMT or reserpine together with 5-HTP further elevated serum prolactin but prevented any significant change in serum TSH.	5-Hydroxytryptophan	50-55	prolactin	Rattus norvegicus	79-88
4544920-0	1974	Effect of 5-hydroxytryptophan (5-HTP) on plasma prolactin levels in man.	5-Hydroxytryptophan	10-29	prolactin	Homo sapiens	48-57
4295-11	1975	Preincubation of rabbit pancreas with the serotonin precursor 5-hydroxytryptophan (5-HTP) increases the beta cell serotonin content and inhibits glucose-stimulated insulin secretion.	5-Hydroxytryptophan	62-81	insulin	Oryctolagus cuniculus	164-171
4295-11	1975	Preincubation of rabbit pancreas with the serotonin precursor 5-hydroxytryptophan (5-HTP) increases the beta cell serotonin content and inhibits glucose-stimulated insulin secretion.	5-Hydroxytryptophan	83-88	insulin	Oryctolagus cuniculus	164-171
4544920-0	1974	Effect of 5-hydroxytryptophan (5-HTP) on plasma prolactin levels in man.	5-Hydroxytryptophan	31-36	prolactin	Homo sapiens	48-57
4541674-10	1973	Further studies relating to the possible mechanism of action of L-tryptophan indicated that infusion of 5-hydroxytryptophan represents a much more potent stimulus for the secretion of prolactin and that premedication with the serotonin antagonist, methysergide maleate, serves to blunt the effect of L-tryptophan on prolactin secretion.	5-Hydroxytryptophan	104-123	prolactin	Homo sapiens	184-193
4541674-10	1973	Further studies relating to the possible mechanism of action of L-tryptophan indicated that infusion of 5-hydroxytryptophan represents a much more potent stimulus for the secretion of prolactin and that premedication with the serotonin antagonist, methysergide maleate, serves to blunt the effect of L-tryptophan on prolactin secretion.	5-Hydroxytryptophan	104-123	prolactin	Homo sapiens	316-325
4541771-0	1973	Effect of L-5-HTP on the release of growth hormone, TSH and insulin.	5-Hydroxytryptophan	10-17	growth hormone 1	Homo sapiens	36-50
4541771-0	1973	Effect of L-5-HTP on the release of growth hormone, TSH and insulin.	5-Hydroxytryptophan	10-17	insulin	Homo sapiens	60-67
4257629-5	1971	Intraperitoneal injection of 5-hydroxytryptophan caused a hypothermia which could be reversed into hyperthermia when the rats were pretreated with a MAO inhibitor.5.	5-Hydroxytryptophan	29-48	monoamine oxidase A	Rattus norvegicus	149-152
4543104-0	1973	Growth hormone responses to administration of L-5-hydroxytryptophan (L-5-HTP) in manic-depressive psychoses.	5-Hydroxytryptophan	46-67	growth hormone 1	Homo sapiens	0-14
4543104-0	1973	Growth hormone responses to administration of L-5-hydroxytryptophan (L-5-HTP) in manic-depressive psychoses.	5-Hydroxytryptophan	69-76	growth hormone 1	Homo sapiens	0-14
4537396-0	1972	New degradative routes of 5-hydroxytryptophan and serotonin by intestinal tryptophan 2,3-dioxygenase.	5-Hydroxytryptophan	26-45	tryptophan 2,3-dioxygenase	Homo sapiens	74-100
4344307-0	1973	Effect of 5-hydroxytryptophan (5-HTP) on growth hormone and ACTH release in man.	5-Hydroxytryptophan	10-29	growth hormone 1	Homo sapiens	41-55
4344307-0	1973	Effect of 5-hydroxytryptophan (5-HTP) on growth hormone and ACTH release in man.	5-Hydroxytryptophan	10-29	proopiomelanocortin	Homo sapiens	60-64
4344307-0	1973	Effect of 5-hydroxytryptophan (5-HTP) on growth hormone and ACTH release in man.	5-Hydroxytryptophan	31-36	growth hormone 1	Homo sapiens	41-55
4344307-0	1973	Effect of 5-hydroxytryptophan (5-HTP) on growth hormone and ACTH release in man.	5-Hydroxytryptophan	31-36	proopiomelanocortin	Homo sapiens	60-64
14319307-0	1965	[DISTRIBUTION GND FATE OF 5-HYDROXYTRYPTOPHAN IN MICE].	5-Hydroxytryptophan	26-45	generalized neuroaxonal dystrophy	Mus musculus	14-17
5440301-0	1970	The effects of 5-HTP on para-Chlorophenylalanine (p-CPA) attenuation of "conflict" behavior.	5-Hydroxytryptophan	15-20	carboxypeptidase A1	Homo sapiens	52-55
4869211-4	1968	5-Hydroxytryptophan, by contrast, lowered tryptophan pyrrolase activity but did not sensitize mice to endotoxin.	5-Hydroxytryptophan	0-19	tryptophan 2,3-dioxygenase	Mus musculus	42-62
33835711-8	2021	Treatment with 5-HTP increased milk calcium concentrations (p = 0.02) and calcium release-activated channel protein 1 (ORAI1) mRNA at 56 h and protein at 48 h relative to termination of first infusion (p = 0.008 and p = 0.09, respectively).	5-Hydroxytryptophan	15-20	ORAI calcium release-activated calcium modulator 1	Bos taurus	119-124
13621173-0	1958	Alleviation of the psychological effects of LSD in man by 5-hydroxytryptophan.	5-Hydroxytryptophan	58-77	deoxyribonuclease 1 like 3	Homo sapiens	44-47
14491500-0	1961	Conversion of tryptopan to 5-hydroxytryptophan by phenylalanine hydroxylase.	5-Hydroxytryptophan	27-46	phenylalanine hydroxylase	Homo sapiens	50-75
33432230-4	2021	We find that a continuously high level of IL-2 leads to the persistent activation of STAT5 in CD8+ T cells, which in turn induces strong expression of tryptophan hydroxylase 1, thus catalyzing the conversion to tryptophan to 5-hydroxytryptophan (5-HTP).	5-Hydroxytryptophan	225-244	interleukin 2	Homo sapiens	42-46
33432230-4	2021	We find that a continuously high level of IL-2 leads to the persistent activation of STAT5 in CD8+ T cells, which in turn induces strong expression of tryptophan hydroxylase 1, thus catalyzing the conversion to tryptophan to 5-hydroxytryptophan (5-HTP).	5-Hydroxytryptophan	225-244	signal transducer and activator of transcription 5A	Homo sapiens	85-90
33432230-4	2021	We find that a continuously high level of IL-2 leads to the persistent activation of STAT5 in CD8+ T cells, which in turn induces strong expression of tryptophan hydroxylase 1, thus catalyzing the conversion to tryptophan to 5-hydroxytryptophan (5-HTP).	5-Hydroxytryptophan	225-244	CD8a molecule	Homo sapiens	94-97
33432230-4	2021	We find that a continuously high level of IL-2 leads to the persistent activation of STAT5 in CD8+ T cells, which in turn induces strong expression of tryptophan hydroxylase 1, thus catalyzing the conversion to tryptophan to 5-hydroxytryptophan (5-HTP).	5-Hydroxytryptophan	225-244	tryptophan hydroxylase 1	Homo sapiens	151-175
33432230-4	2021	We find that a continuously high level of IL-2 leads to the persistent activation of STAT5 in CD8+ T cells, which in turn induces strong expression of tryptophan hydroxylase 1, thus catalyzing the conversion to tryptophan to 5-hydroxytryptophan (5-HTP).	5-Hydroxytryptophan	246-251	interleukin 2	Homo sapiens	42-46
33432230-4	2021	We find that a continuously high level of IL-2 leads to the persistent activation of STAT5 in CD8+ T cells, which in turn induces strong expression of tryptophan hydroxylase 1, thus catalyzing the conversion to tryptophan to 5-hydroxytryptophan (5-HTP).	5-Hydroxytryptophan	246-251	signal transducer and activator of transcription 5A	Homo sapiens	85-90
33432230-4	2021	We find that a continuously high level of IL-2 leads to the persistent activation of STAT5 in CD8+ T cells, which in turn induces strong expression of tryptophan hydroxylase 1, thus catalyzing the conversion to tryptophan to 5-hydroxytryptophan (5-HTP).	5-Hydroxytryptophan	246-251	CD8a molecule	Homo sapiens	94-97
33432230-4	2021	We find that a continuously high level of IL-2 leads to the persistent activation of STAT5 in CD8+ T cells, which in turn induces strong expression of tryptophan hydroxylase 1, thus catalyzing the conversion to tryptophan to 5-hydroxytryptophan (5-HTP).	5-Hydroxytryptophan	246-251	tryptophan hydroxylase 1	Homo sapiens	151-175
33432230-5	2021	5-HTP subsequently activates AhR nuclear translocation, causing a coordinated upregulation of inhibitory receptors and downregulation of cytokine and effector-molecule production, thereby rendering T cells dysfunctional in the tumor microenvironment.	5-Hydroxytryptophan	0-5	aryl hydrocarbon receptor	Homo sapiens	29-32
32926198-6	2021	Treatment with 5-HTP (1 mM and above) induced developmental arrest, growth inhibition, and increased cell death in the early embryos without the trophoblasts (E2.5) and those with impaired trophoblasts and in early EBs, whereas later embryos and EBs were more resistant due to the protection of the extraembryonic tissues.	5-Hydroxytryptophan	15-20	integral membrane protein 2A	Mus musculus	159-163
33068678-0	2021	5-HTP Decreases Goat Mammary Epithelial Cells Apoptosis through MAPK/ERK/Bcl-3 pathway.	5-Hydroxytryptophan	0-5	mitogen-activated protein kinase 1	Homo sapiens	69-72
33068678-0	2021	5-HTP Decreases Goat Mammary Epithelial Cells Apoptosis through MAPK/ERK/Bcl-3 pathway.	5-Hydroxytryptophan	0-5	BCL3 transcription coactivator	Homo sapiens	73-78
33068678-6	2021	In this study, 5-HTP treatment decreased cell apoptosis and promoted phosphorylation of ERK1/2 in GMEC.	5-Hydroxytryptophan	15-20	mitogen-activated protein kinase 3	Homo sapiens	88-94
33068678-8	2021	The Annexin V-FITC/PI staining and western blotting results suggested that 5-HTP decreased GMEC apoptosis through ERK1/2 signaling pathway.	5-Hydroxytryptophan	75-80	annexin A5	Homo sapiens	4-13
33068678-8	2021	The Annexin V-FITC/PI staining and western blotting results suggested that 5-HTP decreased GMEC apoptosis through ERK1/2 signaling pathway.	5-Hydroxytryptophan	75-80	mitogen-activated protein kinase 3	Homo sapiens	114-120
33068678-9	2021	And the results of RT-qPCR and western blotting demonstrated that both 5-HTP and ERK1/2 positively regulated Bcl-3 expression.	5-Hydroxytryptophan	71-76	BCL3 transcription coactivator	Homo sapiens	109-114
33068678-10	2021	Sum up all the results, we could draw the conclusion that 5-HTP decreased GMEC apoptosis through MAPK/ERK/Bcl-3 pathway.	5-Hydroxytryptophan	58-63	mitogen-activated protein kinase 1	Homo sapiens	102-105
33068678-10	2021	Sum up all the results, we could draw the conclusion that 5-HTP decreased GMEC apoptosis through MAPK/ERK/Bcl-3 pathway.	5-Hydroxytryptophan	58-63	BCL3 transcription coactivator	Homo sapiens	106-111
32739765-6	2021	5-hydroxytryptophan increased circulating insulin concentrations during the supplementation period, whereas both treatments increased circulating glucose concentration during the withdrawal period.	5-Hydroxytryptophan	0-19	insulin	Bos taurus	42-49
32739765-10	2021	Supplementation of 5-hydroxytryptophan upregulated hepatic mRNA expression of serotonin receptors (ie, 5-HTR1B, -1D, -2A, and -2B), and downregulated pancreatic 5-HTR1F mRNA and insulin-related proteins (ie, Akt and pAkt).	5-Hydroxytryptophan	19-38	5-hydroxytryptamine receptor 1F	Bos taurus	161-168
32739765-10	2021	Supplementation of 5-hydroxytryptophan upregulated hepatic mRNA expression of serotonin receptors (ie, 5-HTR1B, -1D, -2A, and -2B), and downregulated pancreatic 5-HTR1F mRNA and insulin-related proteins (ie, Akt and pAkt).	5-Hydroxytryptophan	19-38	insulin	Bos taurus	178-185
32739765-10	2021	Supplementation of 5-hydroxytryptophan upregulated hepatic mRNA expression of serotonin receptors (ie, 5-HTR1B, -1D, -2A, and -2B), and downregulated pancreatic 5-HTR1F mRNA and insulin-related proteins (ie, Akt and pAkt).	5-Hydroxytryptophan	19-38	AKT serine/threonine kinase 1	Bos taurus	208-211
32739765-11	2021	Fluoxetine-supplemented calves had fewer pancreatic islets per microscopic field with reduced insulin intensity, whereas 5-hydroxytryptophan supplemented calves had increased islet number and area with greater insulin and serotonin and less glucagon intensities.	5-Hydroxytryptophan	121-140	insulin	Bos taurus	210-217
32595527-5	2020	5-HTP treatment tended to upregulate the mRNA level of adiponectin receptor 1 (ADP1R) and ADP2R in abdominal fat but had no significant influence on their protein levels (P > 0.05).	5-Hydroxytryptophan	0-5	adiponectin receptor 1	Gallus gallus	55-77
33375373-2	2020	5-HTP is produced from tryptophan by tryptophan hydroxylase (TPH), which is present in two isoforms (TPH1 and TPH2).	5-Hydroxytryptophan	0-5	tryptophan hydroxylase 1	Homo sapiens	101-105
33375373-2	2020	5-HTP is produced from tryptophan by tryptophan hydroxylase (TPH), which is present in two isoforms (TPH1 and TPH2).	5-Hydroxytryptophan	0-5	tryptophan hydroxylase 2	Homo sapiens	110-114
33095824-6	2020	Treatment with fluoxetine or 5-hydroxytryptophan significantly increased intracellular serotonin concentrations and subsequently increased PTHrP gene expression, which was reduced with transglutaminase inhibition.	5-Hydroxytryptophan	29-48	parathyroid hormone-like peptide	Mus musculus	139-144
32595527-7	2020	Expression of mRNA encoding interleukin (IL), tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor-beta (TGF-beta) decreased after 5-HTP treatment; however, LPS increased expression significantly in 5-HTP-treated chickens compared with CD chickens.	5-Hydroxytryptophan	150-155	lipopolysaccharide induced TNF factor	Gallus gallus	75-84
32595527-7	2020	Expression of mRNA encoding interleukin (IL), tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor-beta (TGF-beta) decreased after 5-HTP treatment; however, LPS increased expression significantly in 5-HTP-treated chickens compared with CD chickens.	5-Hydroxytryptophan	150-155	transforming growth factor alpha	Gallus gallus	124-132
32615731-5	2020	METHODS: Tryptophan hydroxylase 1 (TPH1) is the rate-limiting enzyme during 5-HT synthesis in non-neural peripheral tissues.	5-Hydroxytryptophan	76-80	tryptophan hydroxylase 1	Mus musculus	9-33
32615731-5	2020	METHODS: Tryptophan hydroxylase 1 (TPH1) is the rate-limiting enzyme during 5-HT synthesis in non-neural peripheral tissues.	5-Hydroxytryptophan	76-80	tryptophan hydroxylase 1	Mus musculus	35-39
31697833-6	2019	Sheep infused with 5-HTP and TRP increased blood and milk concentrations of 5-HT on days 3, 6, 9, and 30 of lactation and parathyroid hormone-related protein (PTHrP) on day 3 of prepartum and on days 3, 6, and 15 of lactation (P < 0.05).	5-Hydroxytryptophan	19-24	parathyroid hormone-related protein	Ovis aries	122-157
32098873-0	2020	Site-specific 5-hydroxytryptophan incorporation into apolipoprotein A-I impairs cholesterol efflux activity and high-density lipoprotein biogenesis.	5-Hydroxytryptophan	14-33	apolipoprotein A1	Homo sapiens	53-71
32054265-0	2020	5-Hydroxy-l-tryptophan Promotes the Milk Calcium Level via the miR-99a-3p/ATP2B1 Axis in Goat Mammary Epithelial Cells.	5-Hydroxytryptophan	0-22	plasma membrane calcium-transporting ATPase 1	Capra hircus	74-80
32054265-7	2020	Taken together, we draw the conclusion that 5-HTP promotes the calcium level in colostrum possibly by increasing intracellular calcium of mammary epithelial cells induced by the miR-99a-3p/ATP2B1 axis.	5-Hydroxytryptophan	44-49	plasma membrane calcium-transporting ATPase 1	Capra hircus	189-195
31874188-12	2020	Moreover, we concluded glutamine transaminase-K represents a predominant cytosolic enzyme in rat brain that"s capable of catalyzing in vitro transamination of p-tyrosine and other aromatic amino acids, including the neurotransmitter precursors L-dopa and 5-hydroxytryptophan.	5-Hydroxytryptophan	255-274	kynurenine aminotransferase 1	Rattus norvegicus	23-47
31697833-7	2019	In addition, compared to that of the control group, the TRP or 5-HTP infusion upregulated PTHrP, a sodium/calcium exchanger, plasma membrane Ca2+ ATPase 2, secretory pathway Ca2+ ATPase 1, and calcium sensing receptor mRNA expression in mammary gland and receptor-activated nuclear factor kappa-B ligand mRNA expression in the femur, but had no effect on receptor-activated nuclear factor kappa-B and osteoprotegerin mRNA expression in the femur (P < 0.05).	5-Hydroxytryptophan	63-68	parathyroid hormone-related protein	Ovis aries	90-95
31697833-7	2019	In addition, compared to that of the control group, the TRP or 5-HTP infusion upregulated PTHrP, a sodium/calcium exchanger, plasma membrane Ca2+ ATPase 2, secretory pathway Ca2+ ATPase 1, and calcium sensing receptor mRNA expression in mammary gland and receptor-activated nuclear factor kappa-B ligand mRNA expression in the femur, but had no effect on receptor-activated nuclear factor kappa-B and osteoprotegerin mRNA expression in the femur (P < 0.05).	5-Hydroxytryptophan	63-68	extracellular calcium-sensing receptor	Ovis aries	193-217
31697833-6	2019	Sheep infused with 5-HTP and TRP increased blood and milk concentrations of 5-HT on days 3, 6, 9, and 30 of lactation and parathyroid hormone-related protein (PTHrP) on day 3 of prepartum and on days 3, 6, and 15 of lactation (P < 0.05).	5-Hydroxytryptophan	19-24	parathyroid hormone-related protein	Ovis aries	159-164
31697833-7	2019	In addition, compared to that of the control group, the TRP or 5-HTP infusion upregulated PTHrP, a sodium/calcium exchanger, plasma membrane Ca2+ ATPase 2, secretory pathway Ca2+ ATPase 1, and calcium sensing receptor mRNA expression in mammary gland and receptor-activated nuclear factor kappa-B ligand mRNA expression in the femur, but had no effect on receptor-activated nuclear factor kappa-B and osteoprotegerin mRNA expression in the femur (P < 0.05).	5-Hydroxytryptophan	63-68	tumor necrosis factor receptor superfamily member 11B	Ovis aries	401-416
31038736-9	2019	Restoring 5-HT levels with 5-hydroxytryptophan treatment decreased levels of DNA damage and increased Atr expression.	5-Hydroxytryptophan	27-46	ataxia telangiectasia and Rad3 related	Mus musculus	102-105
28922379-10	2017	Immunofluorescence assays showed an increased number of CASP3- and Ki67-positive cells in Holstein cows infused with 5-HTP on d1 post-partum.	5-Hydroxytryptophan	117-122	caspase 3	Bos taurus	56-61
29935278-6	2019	Tryptophan hydroxylase 2 (TPH2) activity was measured following injection of the aromatic amino acid decarboxylase (AADC)-inhibitor, NSD-1015, and subsequent HPLC detection of 5-hydroxytryptophan (5-HTP) within subregions of the dorsal raphe nucleus (DR) and median raphe nucleus (MnR).	5-Hydroxytryptophan	176-195	tryptophan hydroxylase 2	Mus musculus	0-24
29935278-6	2019	Tryptophan hydroxylase 2 (TPH2) activity was measured following injection of the aromatic amino acid decarboxylase (AADC)-inhibitor, NSD-1015, and subsequent HPLC detection of 5-hydroxytryptophan (5-HTP) within subregions of the dorsal raphe nucleus (DR) and median raphe nucleus (MnR).	5-Hydroxytryptophan	176-195	tryptophan hydroxylase 2	Mus musculus	26-30
29935278-6	2019	Tryptophan hydroxylase 2 (TPH2) activity was measured following injection of the aromatic amino acid decarboxylase (AADC)-inhibitor, NSD-1015, and subsequent HPLC detection of 5-hydroxytryptophan (5-HTP) within subregions of the dorsal raphe nucleus (DR) and median raphe nucleus (MnR).	5-Hydroxytryptophan	197-202	tryptophan hydroxylase 2	Mus musculus	0-24
29935278-6	2019	Tryptophan hydroxylase 2 (TPH2) activity was measured following injection of the aromatic amino acid decarboxylase (AADC)-inhibitor, NSD-1015, and subsequent HPLC detection of 5-hydroxytryptophan (5-HTP) within subregions of the dorsal raphe nucleus (DR) and median raphe nucleus (MnR).	5-Hydroxytryptophan	197-202	tryptophan hydroxylase 2	Mus musculus	26-30
30534058-4	2018	First, we verified that the rate-limiting enzyme tryptophan hydroxylase (TPH2) responsible for converting L-tryptophan into the intermediate 5-hydroxy-L-tryptophan (5-HTP) is expressed in a subset of type II taste bud cells (TBCs) whereas the enzyme aromatic L-aromatic amino acid decarboxylase (AADC) capable of converting 5-HTP into 5-HT is found in type III TBCs.	5-Hydroxytryptophan	141-163	tryptophan hydroxylase 2	Homo sapiens	73-77
30534058-4	2018	First, we verified that the rate-limiting enzyme tryptophan hydroxylase (TPH2) responsible for converting L-tryptophan into the intermediate 5-hydroxy-L-tryptophan (5-HTP) is expressed in a subset of type II taste bud cells (TBCs) whereas the enzyme aromatic L-aromatic amino acid decarboxylase (AADC) capable of converting 5-HTP into 5-HT is found in type III TBCs.	5-Hydroxytryptophan	165-170	tryptophan hydroxylase 2	Homo sapiens	73-77
30534058-4	2018	First, we verified that the rate-limiting enzyme tryptophan hydroxylase (TPH2) responsible for converting L-tryptophan into the intermediate 5-hydroxy-L-tryptophan (5-HTP) is expressed in a subset of type II taste bud cells (TBCs) whereas the enzyme aromatic L-aromatic amino acid decarboxylase (AADC) capable of converting 5-HTP into 5-HT is found in type III TBCs.	5-Hydroxytryptophan	165-170	dopa decarboxylase	Homo sapiens	296-300
30534058-4	2018	First, we verified that the rate-limiting enzyme tryptophan hydroxylase (TPH2) responsible for converting L-tryptophan into the intermediate 5-hydroxy-L-tryptophan (5-HTP) is expressed in a subset of type II taste bud cells (TBCs) whereas the enzyme aromatic L-aromatic amino acid decarboxylase (AADC) capable of converting 5-HTP into 5-HT is found in type III TBCs.	5-Hydroxytryptophan	324-329	tryptophan hydroxylase 2	Homo sapiens	73-77
30221419-0	2018	5-hydroxytryptophan attenuates imiquimod-induced psoriasiform dermatitis probably through inhibition of IL-17A production and keratinocyte activation.	5-Hydroxytryptophan	0-19	interleukin 17A	Mus musculus	104-110
31283708-2	2019	Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme of central serotonin (5-hydroxytryptamine) synthesis which converts l-tryptophan to 5-hydroxytryptophan.	5-Hydroxytryptophan	144-163	tryptophan hydroxylase 2	Mus musculus	0-24
31283708-2	2019	Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme of central serotonin (5-hydroxytryptamine) synthesis which converts l-tryptophan to 5-hydroxytryptophan.	5-Hydroxytryptophan	144-163	tryptophan hydroxylase 2	Mus musculus	26-30
30796964-1	2019	L-Dopa decarboxylase (DDC) catalyzes the decarboxylation of L-Dopa to dopamine and 5-hydroxytryptophan (5-HTP) to serotonin.	5-Hydroxytryptophan	83-102	dopa decarboxylase	Homo sapiens	0-20
30796964-1	2019	L-Dopa decarboxylase (DDC) catalyzes the decarboxylation of L-Dopa to dopamine and 5-hydroxytryptophan (5-HTP) to serotonin.	5-Hydroxytryptophan	83-102	dopa decarboxylase	Homo sapiens	22-25
30796964-1	2019	L-Dopa decarboxylase (DDC) catalyzes the decarboxylation of L-Dopa to dopamine and 5-hydroxytryptophan (5-HTP) to serotonin.	5-Hydroxytryptophan	104-109	dopa decarboxylase	Homo sapiens	0-20
30796964-1	2019	L-Dopa decarboxylase (DDC) catalyzes the decarboxylation of L-Dopa to dopamine and 5-hydroxytryptophan (5-HTP) to serotonin.	5-Hydroxytryptophan	104-109	dopa decarboxylase	Homo sapiens	22-25
30756539-2	2019	Tryptophan hydroxylase (TRH) induces a highly specific catalytic reaction that converts L-tryptophan (tryptophan) to 5-hydroxy-L-tryptophan (5-HTP) that is subsequently used as a substrate by aromatic L-amino acid decarboxylase (DDC) to form 5-HT.	5-Hydroxytryptophan	117-139	tryptophan 5-hydroxylase 1	Bombyx mori	0-22
30756539-2	2019	Tryptophan hydroxylase (TRH) induces a highly specific catalytic reaction that converts L-tryptophan (tryptophan) to 5-hydroxy-L-tryptophan (5-HTP) that is subsequently used as a substrate by aromatic L-amino acid decarboxylase (DDC) to form 5-HT.	5-Hydroxytryptophan	117-139	tryptophan 5-hydroxylase 1	Bombyx mori	24-27
30756539-2	2019	Tryptophan hydroxylase (TRH) induces a highly specific catalytic reaction that converts L-tryptophan (tryptophan) to 5-hydroxy-L-tryptophan (5-HTP) that is subsequently used as a substrate by aromatic L-amino acid decarboxylase (DDC) to form 5-HT.	5-Hydroxytryptophan	141-146	tryptophan 5-hydroxylase 1	Bombyx mori	0-22
30756539-2	2019	Tryptophan hydroxylase (TRH) induces a highly specific catalytic reaction that converts L-tryptophan (tryptophan) to 5-hydroxy-L-tryptophan (5-HTP) that is subsequently used as a substrate by aromatic L-amino acid decarboxylase (DDC) to form 5-HT.	5-Hydroxytryptophan	141-146	tryptophan 5-hydroxylase 1	Bombyx mori	24-27
29933064-10	2018	By reducing the copy number of L-tryptophan module, replacing TPH1 with a more stable mutant form, and promoter regulation of the BH4 module, 5-HTP was produced at a final titer of 1.3 g/L in the shake flask and 5.1 g/L in a fed-batch fermenter with glycerol as the carbon source, both of which were the highest ever reported for microbial production of 5-HTP.	5-Hydroxytryptophan	142-147	tryptophan hydroxylase 1	Homo sapiens	62-66
29617866-8	2018	By knocking down tryptophan hydroxylase-1 (TPH1) or adding 5-hydroxytryptophan (5-HTP) to decrease or increase the levels of 5-HT in GMEC, we observed that 5-HTP increased PTHrP expression in a dose-dependent manner and siTPH1 decreased PTHrP protein expression.	5-Hydroxytryptophan	59-78	parathyroid hormone-related protein	Capra hircus	172-177
29617866-8	2018	By knocking down tryptophan hydroxylase-1 (TPH1) or adding 5-hydroxytryptophan (5-HTP) to decrease or increase the levels of 5-HT in GMEC, we observed that 5-HTP increased PTHrP expression in a dose-dependent manner and siTPH1 decreased PTHrP protein expression.	5-Hydroxytryptophan	80-85	parathyroid hormone-related protein	Capra hircus	172-177
29617866-8	2018	By knocking down tryptophan hydroxylase-1 (TPH1) or adding 5-hydroxytryptophan (5-HTP) to decrease or increase the levels of 5-HT in GMEC, we observed that 5-HTP increased PTHrP expression in a dose-dependent manner and siTPH1 decreased PTHrP protein expression.	5-Hydroxytryptophan	156-161	tryptophan 5-hydroxylase 1	Capra hircus	17-41
29617866-8	2018	By knocking down tryptophan hydroxylase-1 (TPH1) or adding 5-hydroxytryptophan (5-HTP) to decrease or increase the levels of 5-HT in GMEC, we observed that 5-HTP increased PTHrP expression in a dose-dependent manner and siTPH1 decreased PTHrP protein expression.	5-Hydroxytryptophan	156-161	tryptophan 5-hydroxylase 1	Capra hircus	43-47
29617866-8	2018	By knocking down tryptophan hydroxylase-1 (TPH1) or adding 5-hydroxytryptophan (5-HTP) to decrease or increase the levels of 5-HT in GMEC, we observed that 5-HTP increased PTHrP expression in a dose-dependent manner and siTPH1 decreased PTHrP protein expression.	5-Hydroxytryptophan	156-161	parathyroid hormone-related protein	Capra hircus	172-177
29617866-8	2018	By knocking down tryptophan hydroxylase-1 (TPH1) or adding 5-hydroxytryptophan (5-HTP) to decrease or increase the levels of 5-HT in GMEC, we observed that 5-HTP increased PTHrP expression in a dose-dependent manner and siTPH1 decreased PTHrP protein expression.	5-Hydroxytryptophan	156-161	parathyroid hormone-related protein	Capra hircus	237-242
28922379-11	2017	Given the elevated hepatic serotonin content and increased mRNA abundance of 5HTR2B, 5-HTP infusions may be stimulating an autocrine-paracrine adaptation to lactation in the Holstein cow liver.	5-Hydroxytryptophan	85-90	5-hydroxytryptamine receptor 2B	Bos taurus	77-83
27302625-3	2016	The tryptophan hydroxylase-2 (TPH2) enzyme converts L-tryptophan to 5-hydroxytryptophan (5-HTP), a precursor for central nervous system (CNS) serotonin (5-HT) synthesis; and DBA/1 mice have a polymorphism that decreases TPH2 activity.	5-Hydroxytryptophan	68-87	tryptophan hydroxylase 2	Mus musculus	4-28
28456683-12	2017	By comparison, up-regulation of IDO-1 and TPH-1 protein expression in DSS group was suppressed by PA, which was in line with the declined levels of kynurenine (Kyn) and 5-hydroxytryptophan (5-HTP) in plasma.	5-Hydroxytryptophan	169-188	indoleamine 2,3-dioxygenase 1	Mus musculus	32-37
28456683-12	2017	By comparison, up-regulation of IDO-1 and TPH-1 protein expression in DSS group was suppressed by PA, which was in line with the declined levels of kynurenine (Kyn) and 5-hydroxytryptophan (5-HTP) in plasma.	5-Hydroxytryptophan	169-188	tryptophan hydroxylase 1	Mus musculus	42-47
28456683-12	2017	By comparison, up-regulation of IDO-1 and TPH-1 protein expression in DSS group was suppressed by PA, which was in line with the declined levels of kynurenine (Kyn) and 5-hydroxytryptophan (5-HTP) in plasma.	5-Hydroxytryptophan	190-195	indoleamine 2,3-dioxygenase 1	Mus musculus	32-37
28456683-12	2017	By comparison, up-regulation of IDO-1 and TPH-1 protein expression in DSS group was suppressed by PA, which was in line with the declined levels of kynurenine (Kyn) and 5-hydroxytryptophan (5-HTP) in plasma.	5-Hydroxytryptophan	190-195	tryptophan hydroxylase 1	Mus musculus	42-47
28132689-4	2017	In these six affected individuals, whole-exome sequencing (WES) identified biallelic mutations in DNAJC12, which encodes a heat shock co-chaperone family member that interacts with phenylalanine, tyrosine, and tryptophan hydroxylases catalyzing the BH4-activated conversion of phenylalanine into tyrosine, tyrosine into L-dopa (the precursor of dopamine), and tryptophan into 5-hydroxytryptophan (the precursor of serotonin), respectively.	5-Hydroxytryptophan	376-395	DnaJ heat shock protein family (Hsp40) member C12	Homo sapiens	98-105
27692695-5	2016	Adjunctive administration of 5-hydroxytryptophan (5-HTP) safely elevates 5-HTExt beyond the SERT inhibitor effect in humans; however, 5-HTP cannot be a clinically viable drug because of its poor pharmacokinetics.	5-Hydroxytryptophan	29-48	solute carrier family 6 member 4	Homo sapiens	92-96
27692695-5	2016	Adjunctive administration of 5-hydroxytryptophan (5-HTP) safely elevates 5-HTExt beyond the SERT inhibitor effect in humans; however, 5-HTP cannot be a clinically viable drug because of its poor pharmacokinetics.	5-Hydroxytryptophan	50-55	solute carrier family 6 member 4	Homo sapiens	92-96
27302625-3	2016	The tryptophan hydroxylase-2 (TPH2) enzyme converts L-tryptophan to 5-hydroxytryptophan (5-HTP), a precursor for central nervous system (CNS) serotonin (5-HT) synthesis; and DBA/1 mice have a polymorphism that decreases TPH2 activity.	5-Hydroxytryptophan	68-87	tryptophan hydroxylase 2	Mus musculus	30-34
27302625-3	2016	The tryptophan hydroxylase-2 (TPH2) enzyme converts L-tryptophan to 5-hydroxytryptophan (5-HTP), a precursor for central nervous system (CNS) serotonin (5-HT) synthesis; and DBA/1 mice have a polymorphism that decreases TPH2 activity.	5-Hydroxytryptophan	68-87	tryptophan hydroxylase 2	Mus musculus	220-224
27302625-3	2016	The tryptophan hydroxylase-2 (TPH2) enzyme converts L-tryptophan to 5-hydroxytryptophan (5-HTP), a precursor for central nervous system (CNS) serotonin (5-HT) synthesis; and DBA/1 mice have a polymorphism that decreases TPH2 activity.	5-Hydroxytryptophan	89-94	tryptophan hydroxylase 2	Mus musculus	4-28
27302625-3	2016	The tryptophan hydroxylase-2 (TPH2) enzyme converts L-tryptophan to 5-hydroxytryptophan (5-HTP), a precursor for central nervous system (CNS) serotonin (5-HT) synthesis; and DBA/1 mice have a polymorphism that decreases TPH2 activity.	5-Hydroxytryptophan	89-94	tryptophan hydroxylase 2	Mus musculus	30-34
27302625-3	2016	The tryptophan hydroxylase-2 (TPH2) enzyme converts L-tryptophan to 5-hydroxytryptophan (5-HTP), a precursor for central nervous system (CNS) serotonin (5-HT) synthesis; and DBA/1 mice have a polymorphism that decreases TPH2 activity.	5-Hydroxytryptophan	89-94	tryptophan hydroxylase 2	Mus musculus	220-224
26869713-8	2016	Finally, DA(Tph2-/-) rats treated with the 5-HT precursor 5-hydroxytryptophan (5-HTP) partially restored CNS 5-HT and showed increased ventilation (P &lt; 0.05) at a developmental age when it was otherwise attenuated in the mutants.	5-Hydroxytryptophan	58-77	tryptophan hydroxylase 2	Rattus norvegicus	12-16
26830512-2	2016	We have previously found that AADC cells in the spinal cord could increase their ability to produce serotonin (5-hydroxytryptamine) from 5-hydroxytryptophan after spinal cord injury (SCI).	5-Hydroxytryptophan	137-156	dopa decarboxylase	Rattus norvegicus	30-34
26830512-3	2016	Because AADC is a common enzyme catalyzing 5-hydroxytryptophan to serotonin and l-3,4-dihydroxyphenylalanine (l-dopa) to dopamine (DA), it seems likely that the ability of AADC cells using l-dopa to synthesize DA is also increased.	5-Hydroxytryptophan	43-62	dopa decarboxylase	Rattus norvegicus	8-12
26830512-3	2016	Because AADC is a common enzyme catalyzing 5-hydroxytryptophan to serotonin and l-3,4-dihydroxyphenylalanine (l-dopa) to dopamine (DA), it seems likely that the ability of AADC cells using l-dopa to synthesize DA is also increased.	5-Hydroxytryptophan	43-62	dopa decarboxylase	Rattus norvegicus	172-176
26869713-8	2016	Finally, DA(Tph2-/-) rats treated with the 5-HT precursor 5-hydroxytryptophan (5-HTP) partially restored CNS 5-HT and showed increased ventilation (P &lt; 0.05) at a developmental age when it was otherwise attenuated in the mutants.	5-Hydroxytryptophan	79-84	tryptophan hydroxylase 2	Rattus norvegicus	12-16
26710093-1	2016	OBJECTIVE: The tryptophan hydroxylase 1 gene (TPH1) catalyzes the formation of 5-hydroxytryptophan, a precursor to the neurotransmitter serotonin.	5-Hydroxytryptophan	79-98	tryptophan hydroxylase 1	Homo sapiens	15-39
27008988-2	2016	The innate DFR1 gene in the folate synthesis pathway was found to play pivotal roles in 5-hydroxytryptophan synthesis.	5-Hydroxytryptophan	88-107	dihydrofolate reductase	Saccharomyces cerevisiae S288C	11-15
26710093-1	2016	OBJECTIVE: The tryptophan hydroxylase 1 gene (TPH1) catalyzes the formation of 5-hydroxytryptophan, a precursor to the neurotransmitter serotonin.	5-Hydroxytryptophan	79-98	tryptophan hydroxylase 1	Homo sapiens	46-50
26454419-5	2016	This allowed us to measure 5-HTP accumulation as a direct readout of basal versus stress-induced in vivo TPH2 activity.	5-Hydroxytryptophan	27-32	tryptophan hydroxylase 2	Rattus norvegicus	105-109
26623026-5	2015	FAE and QR significantly potentiated pentobarbital-induced [50 mg/kg, intraperitoneal (ip)] sleep (prolonged sleeping time; shortened sleep latency) in a dose-dependent manner, and these effects were augmented by administration of 5-hydroxytryptophan (5-HTP), a precursor of 5-hydroxytryptamine.	5-Hydroxytryptophan	231-250	Janus kinase 3	Mus musculus	0-3
26669765-5	2015	METHODS: Mouse splenocytes were pretreated with 5-HTP or 5-MTP and activated by anti-CD3 plus anti-CD28 antibodies in vitro.	5-Hydroxytryptophan	48-53	CD28 antigen	Mus musculus	99-103
26669765-10	2015	5-HTP administered before induction decreased the disease activities in CIA mice and suppressed the production of TNFalpha, IL-6 and cyclooxygenase-2 in arthritic joints.	5-Hydroxytryptophan	0-5	tumor necrosis factor	Mus musculus	114-122
26669765-10	2015	5-HTP administered before induction decreased the disease activities in CIA mice and suppressed the production of TNFalpha, IL-6 and cyclooxygenase-2 in arthritic joints.	5-Hydroxytryptophan	0-5	interleukin 6	Mus musculus	124-128
26669765-10	2015	5-HTP administered before induction decreased the disease activities in CIA mice and suppressed the production of TNFalpha, IL-6 and cyclooxygenase-2 in arthritic joints.	5-Hydroxytryptophan	0-5	prostaglandin-endoperoxide synthase 2	Mus musculus	133-149
26623026-5	2015	FAE and QR significantly potentiated pentobarbital-induced [50 mg/kg, intraperitoneal (ip)] sleep (prolonged sleeping time; shortened sleep latency) in a dose-dependent manner, and these effects were augmented by administration of 5-hydroxytryptophan (5-HTP), a precursor of 5-hydroxytryptamine.	5-Hydroxytryptophan	252-257	Janus kinase 3	Mus musculus	0-3
26259827-5	2015	The role of endogenous 5-HT in enhancing the effect of amphetamine was confirmed showing that treatment with the 5-HT precursor 5-hydroxytryptophan (10 mg/kg) restored tissue and extracellular levels of brain 5-HT and the effects of amphetamine on striatal NA release and motor activity in Tph2(-/-) mice.	5-Hydroxytryptophan	128-147	tryptophan hydroxylase 2	Mus musculus	290-294
26504602-2	2015	We have previously shown that in the rat spinal cord the activity of aromatic L-amino acid decarboxylase (AADC) cells to produce 5-HT from its precursor (5-hydroxytryptophan, 5-HTP) is dramatically increased following complete spinal cord transection.	5-Hydroxytryptophan	154-173	dopa decarboxylase	Rattus norvegicus	78-104
26053941-7	2015	Moreover, 5-HTP treatment significantly increased serum levels of 5-HT and decreased the expression of Mrp2 and glycoprotein P (P-gp), whereas treatment with pCPA markedly decreased serum levels of 5-HT and increased the expression of Mrp2 and P-gp.	5-Hydroxytryptophan	10-15	ATP binding cassette subfamily B member 4	Rattus norvegicus	103-107
26053941-7	2015	Moreover, 5-HTP treatment significantly increased serum levels of 5-HT and decreased the expression of Mrp2 and glycoprotein P (P-gp), whereas treatment with pCPA markedly decreased serum levels of 5-HT and increased the expression of Mrp2 and P-gp.	5-Hydroxytryptophan	10-15	phosphoglycolate phosphatase	Rattus norvegicus	128-132
26053941-7	2015	Moreover, 5-HTP treatment significantly increased serum levels of 5-HT and decreased the expression of Mrp2 and glycoprotein P (P-gp), whereas treatment with pCPA markedly decreased serum levels of 5-HT and increased the expression of Mrp2 and P-gp.	5-Hydroxytryptophan	10-15	ATP binding cassette subfamily B member 4	Rattus norvegicus	235-239
26053941-7	2015	Moreover, 5-HTP treatment significantly increased serum levels of 5-HT and decreased the expression of Mrp2 and glycoprotein P (P-gp), whereas treatment with pCPA markedly decreased serum levels of 5-HT and increased the expression of Mrp2 and P-gp.	5-Hydroxytryptophan	10-15	phosphoglycolate phosphatase	Rattus norvegicus	244-248
25766472-12	2015	5-HTP also stimulated osteoclastogenesis and increased RANKL/OPG ratio and the number of IL-6 positive osteocytes.	5-Hydroxytryptophan	0-5	TNF superfamily member 11	Rattus norvegicus	55-60
25766472-12	2015	5-HTP also stimulated osteoclastogenesis and increased RANKL/OPG ratio and the number of IL-6 positive osteocytes.	5-Hydroxytryptophan	0-5	TNF receptor superfamily member 11B	Rattus norvegicus	61-64
25766472-12	2015	5-HTP also stimulated osteoclastogenesis and increased RANKL/OPG ratio and the number of IL-6 positive osteocytes.	5-Hydroxytryptophan	0-5	interleukin 6	Rattus norvegicus	89-93
25637699-8	2015	In synuclein overexpressing PC12 cells, levodopa and 5-hydroxytryptophan elicited pargyline-sensitive alpha-synuclein oligomerization.	5-Hydroxytryptophan	53-72	synuclein alpha	Rattus norvegicus	102-117
24788355-4	2015	The increase of both 3-O-methyldopa and 5-hydroxytryptophan on CSF was the most relevant biochemical alteration denoting AADC defect in these subjects.	5-Hydroxytryptophan	40-59	dopa decarboxylase	Homo sapiens	121-125
26504602-2	2015	We have previously shown that in the rat spinal cord the activity of aromatic L-amino acid decarboxylase (AADC) cells to produce 5-HT from its precursor (5-hydroxytryptophan, 5-HTP) is dramatically increased following complete spinal cord transection.	5-Hydroxytryptophan	154-173	dopa decarboxylase	Rattus norvegicus	106-110
26504602-2	2015	We have previously shown that in the rat spinal cord the activity of aromatic L-amino acid decarboxylase (AADC) cells to produce 5-HT from its precursor (5-hydroxytryptophan, 5-HTP) is dramatically increased following complete spinal cord transection.	5-Hydroxytryptophan	175-180	dopa decarboxylase	Rattus norvegicus	78-104
26504602-2	2015	We have previously shown that in the rat spinal cord the activity of aromatic L-amino acid decarboxylase (AADC) cells to produce 5-HT from its precursor (5-hydroxytryptophan, 5-HTP) is dramatically increased following complete spinal cord transection.	5-Hydroxytryptophan	175-180	dopa decarboxylase	Rattus norvegicus	106-110
25089244-1	2014	Tryptophan hydroxylase (TPH) catalyses l-tryptophan into 5-hydroxy-l-tryptophan, which is the first and rate-limiting step of serotonin (5-HT) biosynthesis.	5-Hydroxytryptophan	57-79	tryptophan hydroxylase 1	Rattus norvegicus	0-22
25411059-7	2014	We further investigate the bioactivity of the confirmed metabolites, and identify two microbiota-generated metabolites (5-hydroxy-L-tryptophan and salicylate) as activators of the aryl hydrocarbon receptor.	5-Hydroxytryptophan	120-142	aryl-hydrocarbon receptor	Mus musculus	180-205
25540092-6	2014	Besides enterochromaffin and mast cells, tryptophan hydroxylase 1 (TPH1), primarily expressed in the gastrointestinal tract, is also found in 5-hydroxytryptophan-producing cells (5-HTP cells) in normal intestinal enterocytes, which are thought to essentially shunt 5-HT production in 5-HT-producing cells.	5-Hydroxytryptophan	144-161	tryptophan hydroxylase 1	Homo sapiens	41-65
25540092-6	2014	Besides enterochromaffin and mast cells, tryptophan hydroxylase 1 (TPH1), primarily expressed in the gastrointestinal tract, is also found in 5-hydroxytryptophan-producing cells (5-HTP cells) in normal intestinal enterocytes, which are thought to essentially shunt 5-HT production in 5-HT-producing cells.	5-Hydroxytryptophan	144-161	tryptophan hydroxylase 1	Homo sapiens	67-71
25299122-9	2014	In most cases, addition of exogenous 5-hydroxy-L-tryptophan to the Tph1 deficient mice rescued the phenotype.	5-Hydroxytryptophan	37-59	tryptophan hydroxylase 1	Mus musculus	67-71
25186745-5	2014	We show that, following complete transection of the rat spinal cord at S2 level, AADC cells distal to the lesion acquire the ability to produce 5-HT from its immediate precursor, 5-hydroxytryptophan.	5-Hydroxytryptophan	179-198	dopa decarboxylase	Rattus norvegicus	81-85
25089244-1	2014	Tryptophan hydroxylase (TPH) catalyses l-tryptophan into 5-hydroxy-l-tryptophan, which is the first and rate-limiting step of serotonin (5-HT) biosynthesis.	5-Hydroxytryptophan	57-79	tryptophan hydroxylase 1	Rattus norvegicus	24-27
24189046-4	2014	Accumulation of 5-hydroxytryptophan (5-HTP) after decarboxylase inhibition was used as a measure of the TPH-1 activity.	5-Hydroxytryptophan	16-35	tryptophan hydroxylase 1	Rattus norvegicus	104-109
24936877-0	2014	Engineering bacterial phenylalanine 4-hydroxylase for microbial synthesis of human neurotransmitter precursor 5-hydroxytryptophan.	5-Hydroxytryptophan	110-129	phenylalanine hydroxylase	Homo sapiens	22-49
25024584-1	2014	Aromatic L-amino acid decarboxylase (AADC), a vitamin B6-requiring enzyme that converts L-dopa to dopamine and 5-hydroxytryptophan to serotonin.	5-Hydroxytryptophan	111-130	dopa decarboxylase	Homo sapiens	37-41
24589238-12	2014	5-hydroxytryptophan inhibits COX-2 expression through conversion to 5-MTP.	5-Hydroxytryptophan	0-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
24589238-12	2014	5-hydroxytryptophan inhibits COX-2 expression through conversion to 5-MTP.	5-Hydroxytryptophan	0-19	metallothionein 1B	Homo sapiens	70-73
24971147-5	2014	The top two TCM candidates, 5-hydroxy-L-tryptophan and abrine, have an indole ring and carboxyl group to form the H-bonds with the key residues of PPAR-gamma protein, such as residues Ser289 and Lys367.	5-Hydroxytryptophan	28-50	peroxisome proliferator activated receptor gamma	Homo sapiens	147-157
24971147-8	2014	Hence, we propose 5-hydroxy-L-tryptophan and abrine as potential lead compounds for further study in drug development process with the PPAR-gamma protein.	5-Hydroxytryptophan	18-40	peroxisome proliferator activated receptor gamma	Homo sapiens	135-145
24084697-1	2014	The PET tracer [(11)C]5-hydroxytryptophan ([(11)C]5-HTP), which is converted to [(11)C]5-hydroxytryptamine ([(11)C]5-HT) by aromatic amino acid decarboxylase (AADC), is thought to measure 5-HT synthesis rates.	5-Hydroxytryptophan	22-41	dopa decarboxylase	Rattus norvegicus	159-163
24407024-1	2014	Mammalian Dopa decarboxylase catalyzes the conversion of L-Dopa and L-5-hydroxytryptophan to dopamine and serotonin, respectively.	5-Hydroxytryptophan	68-89	dopa decarboxylase	Homo sapiens	10-28
24589238-5	2014	5-MTP is produced by mesenchymal cells such as fibroblasts via 5-hydroxytryptophan (5-HTP).	5-Hydroxytryptophan	63-82	metallothionein 1B	Homo sapiens	2-5
24589238-5	2014	5-MTP is produced by mesenchymal cells such as fibroblasts via 5-hydroxytryptophan (5-HTP).	5-Hydroxytryptophan	84-89	metallothionein 1B	Homo sapiens	2-5
24523905-7	2014	Addition of 5-methoxytryptophan and its metabolic precursor, 5-hydroxytryptophan, to quiescent fibroblasts suppressed PMA-induced p300 histone acetyltransferase activity and cyclooxygenase-2 expression to the level of proliferative fibroblasts.	5-Hydroxytryptophan	61-80	E1A binding protein p300	Homo sapiens	130-134
24523905-7	2014	Addition of 5-methoxytryptophan and its metabolic precursor, 5-hydroxytryptophan, to quiescent fibroblasts suppressed PMA-induced p300 histone acetyltransferase activity and cyclooxygenase-2 expression to the level of proliferative fibroblasts.	5-Hydroxytryptophan	61-80	prostaglandin-endoperoxide synthase 2	Homo sapiens	174-190
24523905-8	2014	Silencing of tryptophan hydroxylase-1 or hydroxyindole O-methyltransferase in proliferative fibroblasts with siRNA resulted in elevation of PMA-induced p300 histone acetyltransferase activity to the level of that in quiescent fibroblasts, which was rescued by addition of 5-hydroxytryptophan or 5-methoxytryptophan.	5-Hydroxytryptophan	272-291	tryptophan hydroxylase 1	Homo sapiens	13-74
24523905-8	2014	Silencing of tryptophan hydroxylase-1 or hydroxyindole O-methyltransferase in proliferative fibroblasts with siRNA resulted in elevation of PMA-induced p300 histone acetyltransferase activity to the level of that in quiescent fibroblasts, which was rescued by addition of 5-hydroxytryptophan or 5-methoxytryptophan.	5-Hydroxytryptophan	272-291	E1A binding protein p300	Homo sapiens	152-156
24227628-5	2014	The 8.5 kb gene cluster encodes eight proteins (PsmA-H), seven of which are required for the synthesis of physostigmine from 5-hydroxytryptophan, as shown by in vitro total reconstitution.	5-Hydroxytryptophan	125-144	folate hydrolase 1	Homo sapiens	48-52
24068759-5	2014	In contrast, when we applied exogenous 5-HTP (in vitro or in vivo), AADC-containing vessels and neurons synthesized 5-HT, which contributed to increased motoneuron activity and muscle spasms (long-lasting reflexes, LLRs), by acting on 5-HT2 receptors (SB206553 sensitive) located on motoneurons (TTX resistant).	5-Hydroxytryptophan	39-44	dopa decarboxylase	Rattus norvegicus	68-72
24068759-6	2014	Blocking monoamine oxidase (MAO) markedly increased the sensitivity of the motoneurons (LLR) to 5-HTP, more than it increased the sensitivity of motoneurons to 5-HT, suggesting that 5-HT synthesized from AADC is largely metabolized in AADC-containing neurons and vessels.	5-Hydroxytryptophan	96-101	monoamine oxidase A	Rattus norvegicus	9-26
24068759-6	2014	Blocking monoamine oxidase (MAO) markedly increased the sensitivity of the motoneurons (LLR) to 5-HTP, more than it increased the sensitivity of motoneurons to 5-HT, suggesting that 5-HT synthesized from AADC is largely metabolized in AADC-containing neurons and vessels.	5-Hydroxytryptophan	96-101	monoamine oxidase A	Rattus norvegicus	28-31
23433710-9	2013	Supplemental 5-HTP also resulted in increased concentrations of mammary 5-HT and PTHrP, as well as increased mRNA expression of rate-limiting enzyme in 5-HT synthesis, tryptophan hydroxylase 1, and Pthrp mRNA on day 9 of lactation (P &lt; 0.028).	5-Hydroxytryptophan	13-18	parathyroid hormone-like hormone	Rattus norvegicus	81-86
24369991-6	2013	Additionally, the mechanisms involved in the antidepressant-like action of MAK were investigated by the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP)- or 5-HT2A agonist (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI)-induced head twitch responses.	5-Hydroxytryptophan	124-146	male germ cell-associated kinase	Rattus norvegicus	75-78
24369991-6	2013	Additionally, the mechanisms involved in the antidepressant-like action of MAK were investigated by the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP)- or 5-HT2A agonist (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI)-induced head twitch responses.	5-Hydroxytryptophan	148-153	male germ cell-associated kinase	Rattus norvegicus	75-78
24369991-7	2013	RESULTS: Treatment with MAK (1 g/kg) exhibited antidepressant-like effects in the forced swimming test, attenuated freezing behavior in the contextual fear-conditioning test, and decreased the number of head twitches induced by DOI, but not with 5-HTP.	5-Hydroxytryptophan	246-251	male germ cell-associated kinase	Rattus norvegicus	24-27
22964922-3	2013	MAOA/B-knockout (KO) mice displayed baseline serotonin syndrome behaviors, and these behavioral responses were highly exaggerated following 5-HTP or tramadol versus baseline and wild-type (WT) littermates.	5-Hydroxytryptophan	140-145	monoamine oxidase A	Mus musculus	0-4
22964922-5	2013	Following 5-HTP, serotonin levels were further increased ~4.5-6.2-fold in MAOA/B-KO mice.	5-Hydroxytryptophan	10-15	monoamine oxidase A	Mus musculus	74-78
23935583-7	2013	When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy-L-tryptophan (5-HTP), neurons from both Tph2-/- and Sert-/- mice decreased their firing rates at significantly lower concentrations of 5-HTP compared to wildtype controls.	5-Hydroxytryptophan	75-97	tryptophan hydroxylase 2	Mus musculus	9-13
23935583-7	2013	When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy-L-tryptophan (5-HTP), neurons from both Tph2-/- and Sert-/- mice decreased their firing rates at significantly lower concentrations of 5-HTP compared to wildtype controls.	5-Hydroxytryptophan	75-97	tryptophan hydroxylase 2	Mus musculus	125-129
23935583-7	2013	When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy-L-tryptophan (5-HTP), neurons from both Tph2-/- and Sert-/- mice decreased their firing rates at significantly lower concentrations of 5-HTP compared to wildtype controls.	5-Hydroxytryptophan	99-104	tryptophan hydroxylase 2	Mus musculus	9-13
23935583-7	2013	When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy-L-tryptophan (5-HTP), neurons from both Tph2-/- and Sert-/- mice decreased their firing rates at significantly lower concentrations of 5-HTP compared to wildtype controls.	5-Hydroxytryptophan	99-104	tryptophan hydroxylase 2	Mus musculus	125-129
23935583-7	2013	When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy-L-tryptophan (5-HTP), neurons from both Tph2-/- and Sert-/- mice decreased their firing rates at significantly lower concentrations of 5-HTP compared to wildtype controls.	5-Hydroxytryptophan	220-225	tryptophan hydroxylase 2	Mus musculus	9-13
23935583-7	2013	When the Tph2-dependent 5-HT synthesis step was bypassed by application of 5-hydroxy-L-tryptophan (5-HTP), neurons from both Tph2-/- and Sert-/- mice decreased their firing rates at significantly lower concentrations of 5-HTP compared to wildtype controls.	5-Hydroxytryptophan	220-225	tryptophan hydroxylase 2	Mus musculus	125-129
23558391-8	2013	Whereas 1-2 h of 5-HTP treatment improved the gasp latency and fB of P8-9 TPH2(-/-) pups, improved cardiorespiratory recovery and survival required 24 h of treatment.	5-Hydroxytryptophan	17-22	inner membrane protein, mitochondrial	Mus musculus	69-73
23558391-8	2013	Whereas 1-2 h of 5-HTP treatment improved the gasp latency and fB of P8-9 TPH2(-/-) pups, improved cardiorespiratory recovery and survival required 24 h of treatment.	5-Hydroxytryptophan	17-22	tryptophan hydroxylase 2	Mus musculus	74-78
23370601-7	2013	Nearly all of the DsRedT3/CCK-expressing neurones also expressed 5-hydroxytryptophan (5-HT).	5-Hydroxytryptophan	65-84	cholecystokinin	Mus musculus	26-29
23433710-9	2013	Supplemental 5-HTP also resulted in increased concentrations of mammary 5-HT and PTHrP, as well as increased mRNA expression of rate-limiting enzyme in 5-HT synthesis, tryptophan hydroxylase 1, and Pthrp mRNA on day 9 of lactation (P &lt; 0.028).	5-Hydroxytryptophan	13-18	parathyroid hormone-like hormone	Rattus norvegicus	198-203
22829864-9	2012	Incubation of cardiac homogenate with the AADC substrate (5-hydroxy-L-tryptophan) 5-HTP or intraperitoneal injection of 5-HTP in mice significantly increased cardiac 5-HT.	5-Hydroxytryptophan	58-80	dopa decarboxylase	Mus musculus	42-46
22443164-7	2012	Restoration of 5HT levels by treatment of Tph2-/- mice with its immediate precursor 5-hydroxytryptophan attenuated compulsive and impulsive-aggressive behaviors.	5-Hydroxytryptophan	84-103	tryptophan hydroxylase 2	Mus musculus	42-46
23430895-1	2012	Aromatic L-amino acid decarboxylase (AADC) decarboxylates 3,4-L-dihydroxylphenylalanine (L-dopa) to dopamine, and 5-hydroxytryptophan to serotonin.	5-Hydroxytryptophan	114-133	dopa decarboxylase	Homo sapiens	0-35
23430895-1	2012	Aromatic L-amino acid decarboxylase (AADC) decarboxylates 3,4-L-dihydroxylphenylalanine (L-dopa) to dopamine, and 5-hydroxytryptophan to serotonin.	5-Hydroxytryptophan	114-133	dopa decarboxylase	Homo sapiens	37-41
23264832-1	2012	Dopa decarboxylase (DDC) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that by catalyzing the decarboxylation of L-Dopa and L-5-hydroxytryptophan produces the neurotransmitters dopamine and serotonin.	5-Hydroxytryptophan	129-150	dopa decarboxylase	Homo sapiens	0-18
23264832-1	2012	Dopa decarboxylase (DDC) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that by catalyzing the decarboxylation of L-Dopa and L-5-hydroxytryptophan produces the neurotransmitters dopamine and serotonin.	5-Hydroxytryptophan	129-150	pyridoxal phosphatase	Homo sapiens	54-57
23469086-7	2013	Feeding 5-HTP resulted in increased mRNA expression of key gluconeogenic and glycolytic enzymes in liver and glucose transporters 1 and 8 (GLUT-1, -8) in the mammary gland.	5-Hydroxytryptophan	8-13	solute carrier family 2 member 1	Rattus norvegicus	139-145
23000748-16	2012	This observation offers perspectives for the development of a more selective PET tracer for beta-cell mass, based on an (11)C-hydroxytryptophan derivative with increased resistance toward degradation by MAO-A.	5-Hydroxytryptophan	126-143	monoamine oxidase A	Homo sapiens	203-208
22954188-4	2012	Here we report a novel MPO-sensing probe obtained by replacing the reducing substrate serotonin (5-HT) with 5-hydroxytryptophan (HTrp).	5-Hydroxytryptophan	108-127	myeloperoxidase	Mus musculus	23-26
22954188-4	2012	Here we report a novel MPO-sensing probe obtained by replacing the reducing substrate serotonin (5-HT) with 5-hydroxytryptophan (HTrp).	5-Hydroxytryptophan	129-133	myeloperoxidase	Mus musculus	23-26
22829864-9	2012	Incubation of cardiac homogenate with the AADC substrate (5-hydroxy-L-tryptophan) 5-HTP or intraperitoneal injection of 5-HTP in mice significantly increased cardiac 5-HT.	5-Hydroxytryptophan	82-87	dopa decarboxylase	Mus musculus	42-46
21130784-6	2011	TPH activity was assessed by accumulation of 5-hydroxytryptophan, a rapidly decarboxylated intermediate metabolite of tryptophan and precursor of 5-HT, using an enzyme inhibition strategy.	5-Hydroxytryptophan	45-64	tryptophan hydroxylase 1	Mus musculus	0-3
22115400-1	2011	Ziprasidone, a benzisothiazolyl piperazine derivative of tiospirone, is a second-generation antipsychotic with high-affinity antagonism for 5-hydroxytryptophan (5HT)(2A), 5HT(2C), 5HT(1D) and D(2) receptors, pre- and post-synaptic agonism for 5HT(1A) receptors, and inhibition of reuptake for serotonin and norepinephrine.	5-Hydroxytryptophan	161-164	5-hydroxytryptamine receptor 2C	Homo sapiens	171-177
22115400-1	2011	Ziprasidone, a benzisothiazolyl piperazine derivative of tiospirone, is a second-generation antipsychotic with high-affinity antagonism for 5-hydroxytryptophan (5HT)(2A), 5HT(2C), 5HT(1D) and D(2) receptors, pre- and post-synaptic agonism for 5HT(1A) receptors, and inhibition of reuptake for serotonin and norepinephrine.	5-Hydroxytryptophan	161-164	5-hydroxytryptamine receptor 1D	Homo sapiens	180-186
21699597-3	2011	Complementary DNA of tryptophan hydroxylase and phenylalanine-tryptophan hydroxylase, which convert tryptophan into 5-hydroxy-L-tryptophan (5-HTP), and that of aromatic L-amino acid decarboxylase, which converts 5-HTP into 5-HT, were isolated from a cricket brain cDNA library.	5-Hydroxytryptophan	116-138	Tryptophan hydroxylase	Drosophila melanogaster	21-43
21699597-3	2011	Complementary DNA of tryptophan hydroxylase and phenylalanine-tryptophan hydroxylase, which convert tryptophan into 5-hydroxy-L-tryptophan (5-HTP), and that of aromatic L-amino acid decarboxylase, which converts 5-HTP into 5-HT, were isolated from a cricket brain cDNA library.	5-Hydroxytryptophan	116-138	Tryptophan hydroxylase	Drosophila melanogaster	62-84
21699597-3	2011	Complementary DNA of tryptophan hydroxylase and phenylalanine-tryptophan hydroxylase, which convert tryptophan into 5-hydroxy-L-tryptophan (5-HTP), and that of aromatic L-amino acid decarboxylase, which converts 5-HTP into 5-HT, were isolated from a cricket brain cDNA library.	5-Hydroxytryptophan	140-145	Tryptophan hydroxylase	Drosophila melanogaster	21-43
21699597-3	2011	Complementary DNA of tryptophan hydroxylase and phenylalanine-tryptophan hydroxylase, which convert tryptophan into 5-hydroxy-L-tryptophan (5-HTP), and that of aromatic L-amino acid decarboxylase, which converts 5-HTP into 5-HT, were isolated from a cricket brain cDNA library.	5-Hydroxytryptophan	140-145	Tryptophan hydroxylase	Drosophila melanogaster	62-84
21699597-3	2011	Complementary DNA of tryptophan hydroxylase and phenylalanine-tryptophan hydroxylase, which convert tryptophan into 5-hydroxy-L-tryptophan (5-HTP), and that of aromatic L-amino acid decarboxylase, which converts 5-HTP into 5-HT, were isolated from a cricket brain cDNA library.	5-Hydroxytryptophan	212-217	Tryptophan hydroxylase	Drosophila melanogaster	21-43
21699597-3	2011	Complementary DNA of tryptophan hydroxylase and phenylalanine-tryptophan hydroxylase, which convert tryptophan into 5-hydroxy-L-tryptophan (5-HTP), and that of aromatic L-amino acid decarboxylase, which converts 5-HTP into 5-HT, were isolated from a cricket brain cDNA library.	5-Hydroxytryptophan	212-217	Tryptophan hydroxylase	Drosophila melanogaster	62-84
21441904-5	2011	Thirty-five minutes after the injection of the intermediate 5-hydroxytryptophan (5-HTP), which circumvented Tph2 to restore 5-HT to the wild-type level, adult Tph2 knockout mice also preferred females over males.	5-Hydroxytryptophan	60-79	tryptophan hydroxylase 2	Mus musculus	108-112
21441904-5	2011	Thirty-five minutes after the injection of the intermediate 5-hydroxytryptophan (5-HTP), which circumvented Tph2 to restore 5-HT to the wild-type level, adult Tph2 knockout mice also preferred females over males.	5-Hydroxytryptophan	60-79	tryptophan hydroxylase 2	Mus musculus	159-163
21441904-5	2011	Thirty-five minutes after the injection of the intermediate 5-hydroxytryptophan (5-HTP), which circumvented Tph2 to restore 5-HT to the wild-type level, adult Tph2 knockout mice also preferred females over males.	5-Hydroxytryptophan	81-86	tryptophan hydroxylase 2	Mus musculus	108-112
21441904-5	2011	Thirty-five minutes after the injection of the intermediate 5-hydroxytryptophan (5-HTP), which circumvented Tph2 to restore 5-HT to the wild-type level, adult Tph2 knockout mice also preferred females over males.	5-Hydroxytryptophan	81-86	tryptophan hydroxylase 2	Mus musculus	159-163
21156177-8	2011	Differential expression of tph2 was observed at mRNA and protein levels in the POA-HYP and OCT regions of male and female brains during development that further correlate with the 5-hydroxytryptophan (5-HTP) and 5-HT levels measured using HPLC method in these regions of male and female brains.	5-Hydroxytryptophan	180-199	tryptophan 5-hydroxylase 2	Cricetulus griseus	27-31
21156177-8	2011	Differential expression of tph2 was observed at mRNA and protein levels in the POA-HYP and OCT regions of male and female brains during development that further correlate with the 5-hydroxytryptophan (5-HTP) and 5-HT levels measured using HPLC method in these regions of male and female brains.	5-Hydroxytryptophan	201-206	tryptophan 5-hydroxylase 2	Cricetulus griseus	27-31
21475622-9	2011	RESULTS: When 5-HTP and l-dopa are administered in proper balance along with l-tyrosine, l-cysteine, and cofactors under the guidance of OCT assay interpretation, the long list of problems that can interfere with optimum administration of l-dopa becomes controllable and manageable or does not occur at all.	5-Hydroxytryptophan	14-19	plexin A2	Homo sapiens	137-140
20655180-6	2010	CRH release was induced by administering an oral 5-hydroxytryptophan (5-HTP) 200 mg function test.	5-Hydroxytryptophan	49-68	corticotropin releasing hormone	Homo sapiens	0-3
20813116-7	2011	The potentiation of HAL-induced EPS by 5-HTP (50mg/kg, i.p.)	5-Hydroxytryptophan	39-44	histidine ammonia lyase	Mus musculus	20-23
21224416-7	2011	Similarly, we reinvestigated a tryptophanyl AARS reported to allow the site-selective incorporation of 5-hydroxy tryptophan within mammalian cells.	5-Hydroxytryptophan	103-123	alanyl-tRNA synthetase 1	Homo sapiens	44-48
20655180-6	2010	CRH release was induced by administering an oral 5-hydroxytryptophan (5-HTP) 200 mg function test.	5-Hydroxytryptophan	70-75	corticotropin releasing hormone	Homo sapiens	0-3
20624941-7	2010	In addition, we show that these latter 5-hydroxytryptophan metabolites inhibit IL-17 production.	5-Hydroxytryptophan	39-58	interleukin 17A	Homo sapiens	79-84
22110352-4	2010	Neuropeptide Y (NPY) expression in the arcuate nucleus increased after 3 days of 5-HTP treatment, as high as in the pair-fed group.	5-Hydroxytryptophan	81-86	neuropeptide Y	Rattus norvegicus	0-14
22110352-4	2010	Neuropeptide Y (NPY) expression in the arcuate nucleus increased after 3 days of 5-HTP treatment, as high as in the pair-fed group.	5-Hydroxytryptophan	81-86	neuropeptide Y	Rattus norvegicus	16-19
22110352-7	2010	Results suggest that increased pERK1/2 in the PVN of 5-HTP injected rats may be a part of serotonergic anorectic signaling, perhaps blunting the orectic action of NPY; i.e., 5-HTP injected rats showed hypophagia despite of increased NPY expression in the arcuate nucleus.	5-Hydroxytryptophan	53-58	neuropeptide Y	Rattus norvegicus	163-166
22110352-7	2010	Results suggest that increased pERK1/2 in the PVN of 5-HTP injected rats may be a part of serotonergic anorectic signaling, perhaps blunting the orectic action of NPY; i.e., 5-HTP injected rats showed hypophagia despite of increased NPY expression in the arcuate nucleus.	5-Hydroxytryptophan	53-58	neuropeptide Y	Rattus norvegicus	233-236
22110352-7	2010	Results suggest that increased pERK1/2 in the PVN of 5-HTP injected rats may be a part of serotonergic anorectic signaling, perhaps blunting the orectic action of NPY; i.e., 5-HTP injected rats showed hypophagia despite of increased NPY expression in the arcuate nucleus.	5-Hydroxytryptophan	174-179	neuropeptide Y	Rattus norvegicus	163-166
20880398-7	2010	KEY RESULTS In SLC36A1-expressing oocytes, an inward current was induced by Gly-Sar, Gly-Gly, delta-aminolevulinic acid, beta-aminoethylglycine, delta-aminopentanoic acid, GABA, Gly and Pro, whereas Val, Leu, mannitol, 5-HTP and the dipeptides Gly-Ala, Gly-Pro and Gly-Phe did not evoke currents.	5-Hydroxytryptophan	219-224	solute carrier family 36 member 1	Homo sapiens	15-22
20687613-1	2010	Tryptophan hydroxylase (TrpH) uses a non-heme mononuclear iron center to catalyze the tetrahydropterin-dependent hydroxylation of tryptophan to 5-hydroxytryptophan.	5-Hydroxytryptophan	144-163	tryptophan hydroxylase 1	Homo sapiens	0-22
20687613-1	2010	Tryptophan hydroxylase (TrpH) uses a non-heme mononuclear iron center to catalyze the tetrahydropterin-dependent hydroxylation of tryptophan to 5-hydroxytryptophan.	5-Hydroxytryptophan	144-163	tryptophan hydroxylase 1	Homo sapiens	24-28
20138102-7	2010	5-HTP-induced significant ACTH release reaching an E(max) of 60.2ng/L at 80min followed by cortisol with an E(max) of 246.4ng/mL at 110min.	5-Hydroxytryptophan	0-5	proopiomelanocortin	Homo sapiens	26-30
20415419-3	2010	In this study, we tested the hypothesis that 5HTP exerts its antioxidative action against oxidative stress and inflammation by suppressing the activation of the key pro-inflammatory transcriptional pathways, p38 mitogen-activated protein kinase (p38MAPK) and nuclear factor-kappaB (NF-kappaB).	5-Hydroxytryptophan	45-49	mitogen-activated protein kinase 14	Homo sapiens	208-244
20415419-3	2010	In this study, we tested the hypothesis that 5HTP exerts its antioxidative action against oxidative stress and inflammation by suppressing the activation of the key pro-inflammatory transcriptional pathways, p38 mitogen-activated protein kinase (p38MAPK) and nuclear factor-kappaB (NF-kappaB).	5-Hydroxytryptophan	45-49	mitogen-activated protein kinase 14	Homo sapiens	246-253
20415419-8	2010	Western blot analysis revealed that 5HTP also markedly increased Bcl-2 expression and suppressed both p38MAPK and NF-kappaB activation in the t-BHP-treated human fibroblast cells.	5-Hydroxytryptophan	36-40	BCL2 apoptosis regulator	Homo sapiens	65-70
20415419-8	2010	Western blot analysis revealed that 5HTP also markedly increased Bcl-2 expression and suppressed both p38MAPK and NF-kappaB activation in the t-BHP-treated human fibroblast cells.	5-Hydroxytryptophan	36-40	mitogen-activated protein kinase 14	Homo sapiens	102-109
19892938-6	2010	PYY suppression of intraperitoneal 5-hydroxytryptophan induced FPO and diarrhea was blocked by the Y(2) antagonist, BIIE0246, injected intraperitoneally and mimicked by PYY(3-36), but not [Leu(31),Pro(34)]NPY.	5-Hydroxytryptophan	35-54	peptide YY	Mus musculus	0-3
19900542-2	2010	As both 5-HTP and gaboxadol bind to the human proton-coupled amino acid transporter, hPAT1, a drug-drug interaction at the level of intestinal absorption might occur.	5-Hydroxytryptophan	8-13	solute carrier family 36 member 1	Homo sapiens	85-90
19925800-6	2010	Tph activity of tilapia was confirmed by demonstrating the conversion of L-tryptophan to 5-hydroxy tryptophan by the recombinant protein after transient transfection of this cDNA clone in COS-7 cells.	5-Hydroxytryptophan	89-109	phenylalanine-4-hydroxylase	Oreochromis niloticus	0-3
20337188-10	2010	Supplementation with 5-hydroxytryptophan, but not with levodopa, normalized serotonin metabolism in the CSF, reduced sleep time to 540 min, normalized the eating disorder and the melatonin profile, restored a circadian sleep-wake rhythm (sleep occurred every 24 +/- 1.7 h, P &lt; 0.0001), and improved cognition.	5-Hydroxytryptophan	21-40	colony stimulating factor 2	Homo sapiens	104-107
20098687-2	2010	Physiologically, DDC is responsible for the production of dopamine and serotonin through the decarboxylation of 3,4-dihydroxyphenylalanine and 5-hydroxytryptophan, respectively.	5-Hydroxytryptophan	143-162	Dopa decarboxylase	Drosophila melanogaster	17-20
19892938-6	2010	PYY suppression of intraperitoneal 5-hydroxytryptophan induced FPO and diarrhea was blocked by the Y(2) antagonist, BIIE0246, injected intraperitoneally and mimicked by PYY(3-36), but not [Leu(31),Pro(34)]NPY.	5-Hydroxytryptophan	35-54	peptide YY	Mus musculus	169-172
19892938-6	2010	PYY suppression of intraperitoneal 5-hydroxytryptophan induced FPO and diarrhea was blocked by the Y(2) antagonist, BIIE0246, injected intraperitoneally and mimicked by PYY(3-36), but not [Leu(31),Pro(34)]NPY.	5-Hydroxytryptophan	35-54	neuropeptide Y	Mus musculus	205-208
19429102-4	2009	We measured 5-hydroxytryptophan (5-HTP) accumulation as an index of TPH activity following inhibition of aromatic amino acid decarboxylase (using NSD-1015).	5-Hydroxytryptophan	12-31	tryptophan hydroxylase 1	Rattus norvegicus	68-71
19752879-7	2009	Finally, the study tested whether a single administration of 5HTP-Nat Exts in fasting state has an effect on amino-acid profile and on appetite ratings and whether 5HTP-Nat Exts administered before a fixed test meal has any effect on satiety.	5-Hydroxytryptophan	61-65	bromodomain containing 2	Homo sapiens	66-69
19752879-10	2009	All the amino acids evaluated after a single administration of 5HTP-Nat Exts were found to be similar.	5-Hydroxytryptophan	63-67	bromodomain containing 2	Homo sapiens	68-71
19752879-13	2009	CONCLUSION: All these findings suggest that 5HTP-Nat Exts may be safely used to treat the problem of appetite control in overweight women during a weight loss program.	5-Hydroxytryptophan	44-48	bromodomain containing 2	Homo sapiens	49-52
19789362-5	2010	The selectivity of the nontransported inhibitors 5-hydroxytryptophan and 4-aminomethylbenzoic acid for, respectively, PAT1 and the H(+)-coupled di/tripeptide transporter PepT1 (SLC15A1) were examined.	5-Hydroxytryptophan	49-68	solute carrier family 36 member 1	Homo sapiens	118-122
19789362-5	2010	The selectivity of the nontransported inhibitors 5-hydroxytryptophan and 4-aminomethylbenzoic acid for, respectively, PAT1 and the H(+)-coupled di/tripeptide transporter PepT1 (SLC15A1) were examined.	5-Hydroxytryptophan	49-68	solute carrier family 15 member 1	Homo sapiens	170-175
19789362-5	2010	The selectivity of the nontransported inhibitors 5-hydroxytryptophan and 4-aminomethylbenzoic acid for, respectively, PAT1 and the H(+)-coupled di/tripeptide transporter PepT1 (SLC15A1) were examined.	5-Hydroxytryptophan	49-68	solute carrier family 15 member 1	Homo sapiens	177-184
19789362-6	2010	5-Hydroxytryptophan selectively inhibited PAT1-mediated amino acid uptake across the brush-border membrane of the human intestinal (Caco-2) epithelium whereas 4-aminomethylbenzoic acid selectively inhibited PepT1-mediated dipeptide uptake.	5-Hydroxytryptophan	0-19	solute carrier family 36 member 1	Homo sapiens	42-46
19789362-7	2010	The inhibitory effects of 5-hydroxytryptophan and 4-aminomethylbenzoic acid were additive, demonstrating that both PAT1 and PepT1 contribute to intestinal transport of ALA.	5-Hydroxytryptophan	26-45	solute carrier family 36 member 1	Homo sapiens	115-119
19789362-7	2010	The inhibitory effects of 5-hydroxytryptophan and 4-aminomethylbenzoic acid were additive, demonstrating that both PAT1 and PepT1 contribute to intestinal transport of ALA.	5-Hydroxytryptophan	26-45	solute carrier family 15 member 1	Homo sapiens	124-129
19706294-7	2009	Restoration of 5-HT levels in TPH1(-/-) mice by the 5-HT precursor 5-hydroxytryptophan increased the severity of DSS-induced colitis.	5-Hydroxytryptophan	67-86	tryptophan hydroxylase 1	Mus musculus	30-34
19275775-2	2009	We recently reported a genetic mouse model for the serotonin syndrome, as serotonin transporter (SERT)-deficient mice have exaggerated serotonin syndrome behavioural responses to the MAOI tranylcypromine and the serotonin precursor 5-hydroxy-l-tryptophan (5-HTP).	5-Hydroxytryptophan	232-254	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	74-95
19275775-2	2009	We recently reported a genetic mouse model for the serotonin syndrome, as serotonin transporter (SERT)-deficient mice have exaggerated serotonin syndrome behavioural responses to the MAOI tranylcypromine and the serotonin precursor 5-hydroxy-l-tryptophan (5-HTP).	5-Hydroxytryptophan	232-254	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	97-101
19275775-2	2009	We recently reported a genetic mouse model for the serotonin syndrome, as serotonin transporter (SERT)-deficient mice have exaggerated serotonin syndrome behavioural responses to the MAOI tranylcypromine and the serotonin precursor 5-hydroxy-l-tryptophan (5-HTP).	5-Hydroxytryptophan	256-261	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	74-95
19275775-2	2009	We recently reported a genetic mouse model for the serotonin syndrome, as serotonin transporter (SERT)-deficient mice have exaggerated serotonin syndrome behavioural responses to the MAOI tranylcypromine and the serotonin precursor 5-hydroxy-l-tryptophan (5-HTP).	5-Hydroxytryptophan	256-261	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	97-101
19429102-4	2009	We measured 5-hydroxytryptophan (5-HTP) accumulation as an index of TPH activity following inhibition of aromatic amino acid decarboxylase (using NSD-1015).	5-Hydroxytryptophan	33-38	tryptophan hydroxylase 1	Rattus norvegicus	68-71
19336883-0	2009	5-hydroxytryptophan acts on the mitogen-activated protein kinase extracellular-signal regulated protein kinase pathway to modulate cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 cells.	5-Hydroxytryptophan	0-19	mitogen-activated protein kinase 1	Mus musculus	65-110
19336883-0	2009	5-hydroxytryptophan acts on the mitogen-activated protein kinase extracellular-signal regulated protein kinase pathway to modulate cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 cells.	5-Hydroxytryptophan	0-19	prostaglandin-endoperoxide synthase 2	Mus musculus	131-147
19336883-0	2009	5-hydroxytryptophan acts on the mitogen-activated protein kinase extracellular-signal regulated protein kinase pathway to modulate cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 cells.	5-Hydroxytryptophan	0-19	nitric oxide synthase 2, inducible	Mus musculus	152-183
19336883-6	2009	Our results demonstrated that 5-hydroxytryptophan inhibited the lipopolysaccharide (LPS)-induced expression of NO and IL-6.	5-Hydroxytryptophan	30-49	interleukin 6	Mus musculus	118-122
19336883-7	2009	Furthermore, we found that 5-hydroxytryptophan played a role in LPS induced inducible nitric oxide synthase (iNOS), cyclo oxygenase-2 (COX-2) and extracellular-signal regulated protein kinase (ERK) activation.	5-Hydroxytryptophan	27-46	nitric oxide synthase 2, inducible	Mus musculus	76-107
19336883-7	2009	Furthermore, we found that 5-hydroxytryptophan played a role in LPS induced inducible nitric oxide synthase (iNOS), cyclo oxygenase-2 (COX-2) and extracellular-signal regulated protein kinase (ERK) activation.	5-Hydroxytryptophan	27-46	nitric oxide synthase 2, inducible	Mus musculus	109-113
19336883-7	2009	Furthermore, we found that 5-hydroxytryptophan played a role in LPS induced inducible nitric oxide synthase (iNOS), cyclo oxygenase-2 (COX-2) and extracellular-signal regulated protein kinase (ERK) activation.	5-Hydroxytryptophan	27-46	mitogen-activated protein kinase 1	Mus musculus	146-191
19336883-7	2009	Furthermore, we found that 5-hydroxytryptophan played a role in LPS induced inducible nitric oxide synthase (iNOS), cyclo oxygenase-2 (COX-2) and extracellular-signal regulated protein kinase (ERK) activation.	5-Hydroxytryptophan	27-46	mitogen-activated protein kinase 1	Mus musculus	193-196
19103311-0	2009	Incorporation of 5-hydroxytryptophan into transferrin and its receptor allows assignment of the pH induced changes in intrinsic fluorescence when iron is released.	5-Hydroxytryptophan	17-36	transferrin	Homo sapiens	42-53
18552871-3	2008	Here we used a pharmacokinetic/pharmacodynamic (PK/PD) modelling approach to evaluate the predictive validity of 5-hydroxytryptamine (5-HT; serotonin) transporter (SERT) occupancy and 5-hydroxytryptophan (5-HTP)-potentiated behavioral syndrome induced by 5-HT reuptake inhibitor (SRI) antidepressants in mice.	5-Hydroxytryptophan	184-203	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	164-168
19358813-4	2009	TH and AADC are enzymatically active in a substantial number of monoenzymatic neurons, where they are capable of converting L-tyrosine to L-3,4-dihydroxy-phenylalanine (L-DOPA) and L-DOPA to dopamine (DA) (or 5-hydroxy-tryptophan, 5-HTP to serotonin), respectively.	5-Hydroxytryptophan	209-229	dopa decarboxylase	Homo sapiens	7-11
19358813-4	2009	TH and AADC are enzymatically active in a substantial number of monoenzymatic neurons, where they are capable of converting L-tyrosine to L-3,4-dihydroxy-phenylalanine (L-DOPA) and L-DOPA to dopamine (DA) (or 5-hydroxy-tryptophan, 5-HTP to serotonin), respectively.	5-Hydroxytryptophan	231-236	dopa decarboxylase	Homo sapiens	7-11
18712364-2	2008	OBJECTIVES: To examine the effects of increases in serotonin following the administration of the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) in SERT wild-type (+/+), heterozygous (+/-), and -/- mice.	5-Hydroxytryptophan	117-139	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	151-155
18712364-2	2008	OBJECTIVES: To examine the effects of increases in serotonin following the administration of the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) in SERT wild-type (+/+), heterozygous (+/-), and -/- mice.	5-Hydroxytryptophan	141-146	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	151-155
18712364-4	2008	Behaviorally, 5-HTP induced exaggerated serotonin syndrome behaviors in SERT-/-, mice with similar effects in male and female mice.	5-Hydroxytryptophan	14-19	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	72-76
18712364-6	2008	Physiologically, 5-HTP induced exaggerated temperature effects in SERT-deficient mice.	5-Hydroxytryptophan	17-22	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	66-70
18712364-7	2008	The 5-HT1A antagonist WAY 100635 decreased 5-HTP-induced hypothermia in SERT+/+ and +/- mice with no effect in SERT-/- mice, whereas the 5-HT7 antagonist SB 269970 decreased this exaggerated response in SERT-/- mice only.	5-Hydroxytryptophan	43-48	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	4-10
18712364-7	2008	The 5-HT1A antagonist WAY 100635 decreased 5-HTP-induced hypothermia in SERT+/+ and +/- mice with no effect in SERT-/- mice, whereas the 5-HT7 antagonist SB 269970 decreased this exaggerated response in SERT-/- mice only.	5-Hydroxytryptophan	43-48	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	72-76
18552871-3	2008	Here we used a pharmacokinetic/pharmacodynamic (PK/PD) modelling approach to evaluate the predictive validity of 5-hydroxytryptamine (5-HT; serotonin) transporter (SERT) occupancy and 5-hydroxytryptophan (5-HTP)-potentiated behavioral syndrome induced by 5-HT reuptake inhibitor (SRI) antidepressants in mice.	5-Hydroxytryptophan	205-210	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	164-168
18445233-5	2008	We found that blood 5-HT levels showed a significant augmentation whenever brain 5-HT levels were significantly elevated after the administration of 5-HTP in those rats with the abdominal surgical procedures.	5-Hydroxytryptophan	149-154	POU class 6 homeobox 1	Rattus norvegicus	75-82
18580847-2	2008	The present study examines plasma dehydroepiandrosterone-sulphate (DHEA-S) and the cortisol/DHEA-S ratio following administration of L-5-hydroxytryptophan (5-HTP), the direct precursor of 5-HT, to autistic patients.	5-Hydroxytryptophan	133-154	sulfotransferase family 2A member 1	Homo sapiens	92-98
18580847-4	2008	RESULTS: The 5-HTP-induced DHEA-S responses were significantly higher in autistic patients than in controls.	5-Hydroxytryptophan	13-18	sulfotransferase family 2A member 1	Homo sapiens	27-33
18220075-0	2008	Effects of serotonergic activation by 5-hydroxytryptophan on sleep and body temperature of C57BL/6J and interleukin-6-deficient mice are dose and time related.	5-Hydroxytryptophan	38-57	interleukin 6	Mus musculus	104-117
18209781-5	2008	OBJECTIVES: To determine whether, and to what extent, oral 5-HTP increases urine 5-HIAA excretion and serum CgA levels in healthy volunteers.	5-Hydroxytryptophan	59-64	chromogranin A	Homo sapiens	108-111
18202184-6	2008	5-HTP specifically induced actin remodeling and decreased phosphorylation of extracellular signal-regulated kinase (ERK) in the gut, whereas serotonin stimulated actin remodeling and increased ERK phosphorylation in macrophages.	5-Hydroxytryptophan	0-5	mitogen-activated protein kinase 1	Homo sapiens	77-114
18202184-6	2008	5-HTP specifically induced actin remodeling and decreased phosphorylation of extracellular signal-regulated kinase (ERK) in the gut, whereas serotonin stimulated actin remodeling and increased ERK phosphorylation in macrophages.	5-Hydroxytryptophan	0-5	mitogen-activated protein kinase 1	Homo sapiens	116-119
17590551-5	2008	Combined treatment of BH4, L-Dopa/carbidopa, and 5HTP was started as the CSF neopterin/biopterin ratio (N/B ratio 7.54, control 0.46-1.59) and serum prolactin level (36.79 ng/ml, control &lt;15) were elevated.	5-Hydroxytryptophan	49-53	colony stimulating factor 2	Homo sapiens	73-76
17590551-5	2008	Combined treatment of BH4, L-Dopa/carbidopa, and 5HTP was started as the CSF neopterin/biopterin ratio (N/B ratio 7.54, control 0.46-1.59) and serum prolactin level (36.79 ng/ml, control &lt;15) were elevated.	5-Hydroxytryptophan	49-53	prolactin	Homo sapiens	149-158
17765930-5	2007	SERT +/+ mice developed significant serotonin syndrome behaviors only with the combination of the MAO-A/B inhibitor tranylcypromine (0.5 or 1 mg/kg) or the MAO-A-selective inhibitor clorgyline (1.2 mg/kg) plus 5-HTP.	5-Hydroxytryptophan	210-215	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	0-4
17376153-1	2007	In Drosophila, one enzyme (Drosophila tryptophan-phenylalanine hydroxylase, DTPHu) hydroxylates both tryptophan to yield 5-hydroxytryptophan, the first step in serotonin synthesis, and phenylalanine, to generate tyrosine.	5-Hydroxytryptophan	121-140	Tryptophan hydroxylase	Drosophila melanogaster	76-81
17492791-1	2007	The recent discovery of TPH-2, a new isoform of tryptophan hydroxylase, the enzyme that catalyses the transformation of tryptophan into 5-hydroxytryptophan and the rate-limiting step in brain serotonin (5-HT) biosynthesis, has boosted new interest in the many functions of 5-HT in the brain and non-nervous tissues.	5-Hydroxytryptophan	136-155	tryptophan hydroxylase 2	Mus musculus	24-29
17346140-7	2007	5-Hydroxytryptophan CSF content is higher in HIV-1 infection than in hydrocephalic controls in all districts examined.	5-Hydroxytryptophan	0-19	colony stimulating factor 2	Homo sapiens	20-23
17240182-4	2007	METHODS: We describe assays for plasma AADC enzyme activity using both of its substrates, 5-hydroxytryptophan (5-HTP) and 3,4-dihydroxyphenylalanine (L-dopa).	5-Hydroxytryptophan	90-109	dopa decarboxylase	Homo sapiens	39-43
17240182-4	2007	METHODS: We describe assays for plasma AADC enzyme activity using both of its substrates, 5-hydroxytryptophan (5-HTP) and 3,4-dihydroxyphenylalanine (L-dopa).	5-Hydroxytryptophan	111-116	dopa decarboxylase	Homo sapiens	39-43
17240182-6	2007	RESULTS: AADC enzyme activity in control plasma on average is a factor 8-12 higher with L-dopa as substrate than with 5-HTP.	5-Hydroxytryptophan	118-123	dopa decarboxylase	Homo sapiens	9-13
17240182-8	2007	In AADC deficient patients, the enzyme activity towards both substrates, L-dopa and 5-HTP, are equally decreased, as are the CSF concentrations of HVA, 5-HIAA and MHPG, whereas heterozygotes have intermediate AADC activity levels.	5-Hydroxytryptophan	84-89	dopa decarboxylase	Homo sapiens	3-7
16707241-10	2007	Plasma ghrelin levels at 20, 40 and 60min after infusion of tryptophan were higher than after saline and 5-hydroxytryptophan infusion, 5-hydroxytryptophan infusion induced lower food intake than saline infusion, and tryptophan infusion increased food intake 2, 8 and 24h after infusion.	5-Hydroxytryptophan	135-154	appetite-regulating hormone	Sus scrofa	7-14
18239778-2	2007	Administration of ultralow-dose antibodies to S-100 protein in combination with serotoninergic agents (ketanserin and 5-hydroxytryptophan) reduced the anxiolytic and antidepressant effects of antibodies.	5-Hydroxytryptophan	118-137	S100 calcium binding protein A1	Homo sapiens	46-51
17578016-5	2007	AADC is enzymatically active in all studied monoenzymatic neurons converting extracellular L-dihydroxyphenylalanine (L-DOPA) or 5-hydroxytryptophan captured from the extracellular space, to DA or serotonin, respectively.	5-Hydroxytryptophan	128-147	dopa decarboxylase	Homo sapiens	0-4
17541259-12	2007	We conclude that the 5-HTP-caused increase in brain serotonin contributed significantly to the dynamics of changes in the osmoregulatory response to the hypo-osmotic challenge due to stimulation of AVP secretion.	5-Hydroxytryptophan	21-26	arginine vasopressin	Rattus norvegicus	198-201
16990446-6	2007	5-HTP (0.5-10 mg/kg) dose dependently increased Fos expression in myenteric neurons, with a maximal response of 9.9 +/- 1.0 cells/ganglion [P &lt; 0.05 vs. vehicle-treated mice (2.3 +/- 0.6 cells/ganglion)].	5-Hydroxytryptophan	0-5	FBJ osteosarcoma oncogene	Mus musculus	48-51
16990446-8	2007	Of Fos-positive ganglionic cells, 40 +/- 4% were also pChAT positive and 21 +/- 5% were NADPH-diaphorase positive in response to 5-HTP, respectively.	5-Hydroxytryptophan	129-134	FBJ osteosarcoma oncogene	Mus musculus	3-6
16990446-10	2007	These results show that 5-HTP injected peripherally increases Fos expression in different populations of cholinergic and nitrergic myenteric neurons in the distal colon and stimulates propulsive colonic motor function through 5-HT4 receptors in conscious mice.	5-Hydroxytryptophan	24-29	FBJ osteosarcoma oncogene	Mus musculus	62-65
16508167-0	2006	Involvement of leptin in hypophagia induced by the serotonin precursor 5-hydroxytryptophan (5-HTP) in mice.	5-Hydroxytryptophan	71-90	leptin	Mus musculus	15-21
17100126-7	2006	For the detection of ectopic ACTH-secreting tumours new imaging techniques, such as somatostatin receptor scintigraphy and positron emission tomography with 5-hydroxytryptophan, have become available.	5-Hydroxytryptophan	157-176	proopiomelanocortin	Homo sapiens	29-33
16953590-1	2006	Phenylalanine hydroxylase (PheH) and tryptophan hydroxylase (TrpH) catalyze the aromatic hydroxylation of phenylalanine and tryptophan, forming tyrosine and 5-hydroxytryptophan, respectively.	5-Hydroxytryptophan	157-176	phenylalanine hydroxylase	Rattus norvegicus	0-25
16953590-1	2006	Phenylalanine hydroxylase (PheH) and tryptophan hydroxylase (TrpH) catalyze the aromatic hydroxylation of phenylalanine and tryptophan, forming tyrosine and 5-hydroxytryptophan, respectively.	5-Hydroxytryptophan	157-176	phenylalanine hydroxylase	Rattus norvegicus	27-31
16888223-3	2006	Here, we show that Adcyap1-/- mice manifest jumping behavior as early as at least 6 weeks of age when compared with wild-type mice and that the selective serotonin (5-HT) reuptake inhibitor, fluoxetine, as well as the serotonin precursor, 5-hydroxytryptophan, suppress jumping behavior.	5-Hydroxytryptophan	239-258	adenylate cyclase activating polypeptide 1	Mus musculus	19-26
16861147-13	2006	In fact, 5HT1A and 5HT2 receptor agonists have been shown to prevent glutamate-induced neurotoxicity in primary cortical cell cultures and the 5-HT precursor 5-hydroxytryptophan (5-HTP) improved locomotor function and survival of transgenic SOD1 G93A mice, an animal model of ALS.	5-Hydroxytryptophan	158-177	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	9-14
16861147-13	2006	In fact, 5HT1A and 5HT2 receptor agonists have been shown to prevent glutamate-induced neurotoxicity in primary cortical cell cultures and the 5-HT precursor 5-hydroxytryptophan (5-HTP) improved locomotor function and survival of transgenic SOD1 G93A mice, an animal model of ALS.	5-Hydroxytryptophan	158-177	superoxide dismutase 1, soluble	Mus musculus	241-245
16861147-13	2006	In fact, 5HT1A and 5HT2 receptor agonists have been shown to prevent glutamate-induced neurotoxicity in primary cortical cell cultures and the 5-HT precursor 5-hydroxytryptophan (5-HTP) improved locomotor function and survival of transgenic SOD1 G93A mice, an animal model of ALS.	5-Hydroxytryptophan	179-184	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	9-14
16861147-13	2006	In fact, 5HT1A and 5HT2 receptor agonists have been shown to prevent glutamate-induced neurotoxicity in primary cortical cell cultures and the 5-HT precursor 5-hydroxytryptophan (5-HTP) improved locomotor function and survival of transgenic SOD1 G93A mice, an animal model of ALS.	5-Hydroxytryptophan	179-184	superoxide dismutase 1, soluble	Mus musculus	241-245
16508167-0	2006	Involvement of leptin in hypophagia induced by the serotonin precursor 5-hydroxytryptophan (5-HTP) in mice.	5-Hydroxytryptophan	92-97	leptin	Mus musculus	15-21
16508167-1	2006	We previously demonstrated that a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) increases serum leptin levels in mice.	5-Hydroxytryptophan	61-80	leptin	Mus musculus	105-111
16508167-1	2006	We previously demonstrated that a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) increases serum leptin levels in mice.	5-Hydroxytryptophan	82-87	leptin	Mus musculus	105-111
16508167-5	2006	Serum leptin levels in fasted mice treated with 5-HTP were similar to those control mice after milk intake.	5-Hydroxytryptophan	48-53	leptin	Mus musculus	6-12
15893130-11	2005	We hypothesize that patients who become depressed on IFN will respond to the synergistic combination of SSRIs plus 5-HTP.	5-Hydroxytryptophan	115-120	interferon alpha 1	Homo sapiens	53-56
16023217-2	2006	In the absence of supplementation with exogenous 5-HTP, the amount of endogenous 5-HTP available for serotonin synthesis depends on the availability of tryptophan and on the activity of various enzymes, especially tryptophan hydroxylase, indoleamine 2,3-dioxygenase, and tryptophan 2,3-dioxygenase (TDO).	5-Hydroxytryptophan	81-86	tryptophan 2,3-dioxygenase	Homo sapiens	271-297
16023217-2	2006	In the absence of supplementation with exogenous 5-HTP, the amount of endogenous 5-HTP available for serotonin synthesis depends on the availability of tryptophan and on the activity of various enzymes, especially tryptophan hydroxylase, indoleamine 2,3-dioxygenase, and tryptophan 2,3-dioxygenase (TDO).	5-Hydroxytryptophan	81-86	tryptophan 2,3-dioxygenase	Homo sapiens	299-302
16488409-3	2006	Administration of the non-selective MAO inhibitor, pargyline, and the selective MAO-A inhibitor, clorgyline, resulted in 5-HT syndrome in 5-HTP-treated rats, and subchronic co-administration of fluvoxamine intensified the syndrome.	5-Hydroxytryptophan	138-143	monoamine oxidase A	Rattus norvegicus	36-39
16488409-3	2006	Administration of the non-selective MAO inhibitor, pargyline, and the selective MAO-A inhibitor, clorgyline, resulted in 5-HT syndrome in 5-HTP-treated rats, and subchronic co-administration of fluvoxamine intensified the syndrome.	5-Hydroxytryptophan	138-143	monoamine oxidase A	Rattus norvegicus	80-85
16032410-5	2005	In acute behavioural assays in mice, the orally administered compound potentiated the 5-hydroxy-tryptophan (5-HTP)-induced syndrome [minimal effective dose (MED) = 10 mg/kg], antagonized the hypothermia induced by a high dose of apomorphine (ED50 = 2 mg/kg) and reduced the immobility in the tail suspension test (MED = 10 mg/kg).	5-Hydroxytryptophan	86-106	mediator complex subunit 10	Mus musculus	314-322
16032410-5	2005	In acute behavioural assays in mice, the orally administered compound potentiated the 5-hydroxy-tryptophan (5-HTP)-induced syndrome [minimal effective dose (MED) = 10 mg/kg], antagonized the hypothermia induced by a high dose of apomorphine (ED50 = 2 mg/kg) and reduced the immobility in the tail suspension test (MED = 10 mg/kg).	5-Hydroxytryptophan	108-113	mediator complex subunit 10	Mus musculus	314-322
16126914-5	2005	When PAT1 was expressed in Xenopus laevis oocytes and analyzed by the two-electrode voltage clamp technique, glycine elicited high inward currents that were dependent on membrane potential but no currents were observed with l-tryptophan, tryptamine, 5-hydroxy-l-tryptophan, or serotonin.	5-Hydroxytryptophan	250-272	solute carrier family 36 member 1	Homo sapiens	5-9
16364672-4	2006	STUDY DESIGN: We reviewed the characteristics of 10 PTPS-deficient patients whose treatment onset with tetrahydrobiopterin, L-DOPA, and hydroxytryptophan had been delayed.	5-Hydroxytryptophan	136-153	6-pyruvoyltetrahydropterin synthase	Homo sapiens	52-56
15994374-10	2005	Intracerebroventricular pretreatment with the CRH receptor antagonist alpha-helical CRH does not alter the impact of 5-HTP on sleep-wake behavior but potentiates the hypothermic response to 50 mg/kg 5-HTP.	5-Hydroxytryptophan	199-204	corticotropin releasing hormone	Rattus norvegicus	46-49
15994374-10	2005	Intracerebroventricular pretreatment with the CRH receptor antagonist alpha-helical CRH does not alter the impact of 5-HTP on sleep-wake behavior but potentiates the hypothermic response to 50 mg/kg 5-HTP.	5-Hydroxytryptophan	199-204	corticotropin releasing hormone	Rattus norvegicus	84-87
15496296-2	2004	Previously, we have shown that 5-HT1B receptors mediate the monosynaptic reflex depression induced by exogenously applied 5-HT that was formed from the precursor L-5-hydroxytryptophan in spinalized rats.	5-Hydroxytryptophan	162-183	5-hydroxytryptamine receptor 1B	Rattus norvegicus	31-37