PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29723743-0	2018	Spiropyrrolidine/spiroindolizino[6,7-b]indole heterocyclic hybrids: Stereoselective synthesis, cholinesterase inhibitory activity and their molecular docking study.	spiropyrrolidine	0-16	butyrylcholinesterase	Homo sapiens	95-109
33424364-0	2021	Cholinesterase inhibitory activity of highly functionalized fluorinated spiropyrrolidine heterocyclic hybrids.	spiropyrrolidine	72-88	butyrylcholinesterase	Homo sapiens	0-14
33424364-2	2021	Among the spiropyrrolidine heterocyclic hybrids, the indole based fluorinated compound with a methoxy substituent at the meta- position of the aryl ring exhibited the utmost potent AChE and BChE inhibitory activities with an IC50 of 1.97 +- 0.19 microM and 7.08 +- 0.20 microM respectively.	spiropyrrolidine	10-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	181-185
33424364-2	2021	Among the spiropyrrolidine heterocyclic hybrids, the indole based fluorinated compound with a methoxy substituent at the meta- position of the aryl ring exhibited the utmost potent AChE and BChE inhibitory activities with an IC50 of 1.97 +- 0.19 microM and 7.08 +- 0.20 microM respectively.	spiropyrrolidine	10-26	butyrylcholinesterase	Homo sapiens	190-194
32340203-0	2020	Three-Component Access to Functionalized Spiropyrrolidine Heterocyclic Scaffolds and Their Cholinesterase Inhibitory Activity.	spiropyrrolidine	41-57	butyrylcholinesterase	Homo sapiens	91-105
31753696-0	2020	Design, synthesis and cholinesterase inhibitory activity of novel spiropyrrolidine tethered imidazole heterocyclic hybrids.	spiropyrrolidine	66-82	butyrylcholinesterase	Homo sapiens	22-36
22468999-0	2012	Discovery and optimization of a novel spiropyrrolidine inhibitor of beta-secretase (BACE1) through fragment-based drug design.	spiropyrrolidine	38-54	beta-secretase 1	Homo sapiens	84-89
22468999-2	2012	An X-ray-based fragment screen of Pfizer"s proprietary fragment collection has resulted in the identification of a novel BACE binder featuring spiropyrrolidine framework.	spiropyrrolidine	143-159	beta-secretase 1	Homo sapiens	121-125
28487071-0	2017	Diversity-oriented sustainable synthesis of antimicrobial spiropyrrolidine/thiapyrrolizidine oxindole derivatives: New ligands for a metallo-beta-lactamase from Klebsiella pneumonia.	spiropyrrolidine	58-74	beta-lactamase	Klebsiella pneumoniae	141-155