PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32278162-8	2020	Moreover, our results indicated that CTN exposure increased the expression of LAMP2, indicating the induction of lysosomal damage.	Citrinin	37-40	lysosomal-associated membrane protein 2	Mus musculus	78-83
30558162-1	2018	The sensitive detection of the mycotoxin citrinin (CIT) utilizing its fluorescence requires approaches to enhance the emission.	Citrinin	41-49	citron rho-interacting serine/threonine kinase	Homo sapiens	51-54
31077037-1	2019	The present study investigated the effects of citrinin (CIT) on a yeast-transformed human DNA methyltransferase (DNMT) associated with flocculation that can be inhibited by epigenetic mutagens.	Citrinin	46-54	DNA methyltransferase 1	Homo sapiens	90-111
31077037-1	2019	The present study investigated the effects of citrinin (CIT) on a yeast-transformed human DNA methyltransferase (DNMT) associated with flocculation that can be inhibited by epigenetic mutagens.	Citrinin	46-54	DNA methyltransferase 1	Homo sapiens	113-117
31077037-1	2019	The present study investigated the effects of citrinin (CIT) on a yeast-transformed human DNA methyltransferase (DNMT) associated with flocculation that can be inhibited by epigenetic mutagens.	Citrinin	56-59	DNA methyltransferase 1	Homo sapiens	90-111
31077037-1	2019	The present study investigated the effects of citrinin (CIT) on a yeast-transformed human DNA methyltransferase (DNMT) associated with flocculation that can be inhibited by epigenetic mutagens.	Citrinin	56-59	DNA methyltransferase 1	Homo sapiens	113-117
31077037-3	2019	In contrast, the same concentrations of CIT had little effect on reporter activity under the control of a less methylation-sensitive FLO1 promoter.	Citrinin	40-43	flocculin FLO1	Saccharomyces cerevisiae S288C	133-137
31077037-4	2019	It was also shown that bacterial DNMT activity could be inhibited in the presence of CIT (4 and 40 mumol/L).	Citrinin	85-88	DNA methyltransferase 1	Homo sapiens	33-37
31204482-0	2019	Combined Inhibitory Effects of Citrinin, Ochratoxin-A, and T-2 Toxin on Aquaporin-2.	Citrinin	31-39	aquaporin 2	Mus musculus	72-83
29230174-4	2017	The cytotoxicity of CTN was evaluated by treating HepG2 (Human hepatocellular carcinoma) cells with CTN (0-150 muM) in a dose dependent manner for 24 h, and the IC50 was determined to be 96.16 muM.	Citrinin	20-23	latexin	Homo sapiens	111-114
29673704-10	2018	Phosphorylation of ERK1/2 was increased by CIT, OTA alone and the mycotoxin combination.	Citrinin	43-46	mitogen-activated protein kinase 3	Homo sapiens	19-25
29474583-0	2018	Ochratoxin A, citrinin and deoxynivalenol decrease claudin-2 expression in mouse rectum CMT93-II cells.	Citrinin	14-22	claudin 2	Mus musculus	51-60
29474583-6	2018	In this study, we examined whether ochratoxin A, citrinin and deoxynivalenol affect claudin-2 expression and ERK1/2 phosphorylation in CMT93-II cells.	Citrinin	49-57	claudin 2	Homo sapiens	84-93
29186930-7	2017	CTN-induced damage processes directly promoted reactive oxygen species (ROS) generation, loss of mitochondrial membrane potential (MMP) and activation of caspase-9 and caspase-3, which were effectively blocked by LQ.	Citrinin	0-3	caspase 9	Mus musculus	154-163
29186930-7	2017	CTN-induced damage processes directly promoted reactive oxygen species (ROS) generation, loss of mitochondrial membrane potential (MMP) and activation of caspase-9 and caspase-3, which were effectively blocked by LQ.	Citrinin	0-3	caspase 3	Mus musculus	168-177
29673704-4	2018	Only concurrent but not individual exposure to OTA and CIT at nanomolar concentrations led to (i) an increase of TNF protein and mRNA, (ii) a decrease of COX-2 protein and mRNA, (iii) a decrease of E-cadherin protein and (iv) an increase of vimentin and alpha-SMA protein.	Citrinin	55-58	tumor necrosis factor	Homo sapiens	113-116
29673704-4	2018	Only concurrent but not individual exposure to OTA and CIT at nanomolar concentrations led to (i) an increase of TNF protein and mRNA, (ii) a decrease of COX-2 protein and mRNA, (iii) a decrease of E-cadherin protein and (iv) an increase of vimentin and alpha-SMA protein.	Citrinin	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
29673704-4	2018	Only concurrent but not individual exposure to OTA and CIT at nanomolar concentrations led to (i) an increase of TNF protein and mRNA, (ii) a decrease of COX-2 protein and mRNA, (iii) a decrease of E-cadherin protein and (iv) an increase of vimentin and alpha-SMA protein.	Citrinin	55-58	cadherin 1	Homo sapiens	198-208
29673704-4	2018	Only concurrent but not individual exposure to OTA and CIT at nanomolar concentrations led to (i) an increase of TNF protein and mRNA, (ii) a decrease of COX-2 protein and mRNA, (iii) a decrease of E-cadherin protein and (iv) an increase of vimentin and alpha-SMA protein.	Citrinin	55-58	vimentin	Homo sapiens	241-249
29524438-8	2018	The hOGG1 modified comet assay revealed kidneys and liver oxidative DNA damage in OTA + CTN treated animals, which was not reversed by RSV.	Citrinin	88-91	8-oxoguanine DNA glycosylase	Homo sapiens	4-9
29230174-4	2017	The cytotoxicity of CTN was evaluated by treating HepG2 (Human hepatocellular carcinoma) cells with CTN (0-150 muM) in a dose dependent manner for 24 h, and the IC50 was determined to be 96.16 muM.	Citrinin	20-23	latexin	Homo sapiens	193-196
29230174-4	2017	The cytotoxicity of CTN was evaluated by treating HepG2 (Human hepatocellular carcinoma) cells with CTN (0-150 muM) in a dose dependent manner for 24 h, and the IC50 was determined to be 96.16 muM.	Citrinin	100-103	latexin	Homo sapiens	111-114
28404941-8	2017	We also examined the ROS level and early apoptosis marker Annexin signals, and the results showed that both levels increased, indicating that citrinin induced oxidative stress and further resulted in oocyte early apoptosis.	Citrinin	142-150	annexin A11, opposite strand	Mus musculus	58-65
28304351-4	2017	Thus, CTN was conjugated to bovine serum albumin (BSA) and ovalbumin (OVA), respectively, by amide bonds using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS).	Citrinin	6-9	albumin	Mus musculus	35-54
28238725-5	2017	Domain dissection and reconstitution of PksCT, the fungal non-reducing PKS (NR-PKS) responsible for the first isolable intermediate in citrinin biosynthesis, demonstrates the role of CMeT-catalyzed methylation in precursor elongation and pentaketide formation.	Citrinin	135-143	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	183-187
27669300-3	2016	Both CIT and OTA cause highly transient transcriptional activation of different stress genes, which is greatly enhanced by the disruption of the multidrug exporter Pdr5.	Citrinin	5-8	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	164-168
29165056-6	2017	Further, the genetic deficiency of the pro-apoptotic protein Bax protected cells against CTN-induced apoptosis, indicating that Bax is required for CTN-mediated toxicity.	Citrinin	89-92	BCL2 associated X, apoptosis regulator	Homo sapiens	61-64
29165056-6	2017	Further, the genetic deficiency of the pro-apoptotic protein Bax protected cells against CTN-induced apoptosis, indicating that Bax is required for CTN-mediated toxicity.	Citrinin	89-92	BCL2 associated X, apoptosis regulator	Homo sapiens	128-131
29165056-6	2017	Further, the genetic deficiency of the pro-apoptotic protein Bax protected cells against CTN-induced apoptosis, indicating that Bax is required for CTN-mediated toxicity.	Citrinin	148-151	BCL2 associated X, apoptosis regulator	Homo sapiens	61-64
29165056-6	2017	Further, the genetic deficiency of the pro-apoptotic protein Bax protected cells against CTN-induced apoptosis, indicating that Bax is required for CTN-mediated toxicity.	Citrinin	148-151	BCL2 associated X, apoptosis regulator	Homo sapiens	128-131
28304351-4	2017	Thus, CTN was conjugated to bovine serum albumin (BSA) and ovalbumin (OVA), respectively, by amide bonds using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS).	Citrinin	6-9	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	59-68
28304351-7	2017	The 21H27 anti-CTN mcAb was the IgG2a antibody subclass, and cross-reactivity results indicated that anti-CTN mcAb is specific to CTN with high affinity (2.0 x 108 L/mol).	Citrinin	15-18	immunoglobulin heavy variable V1-9	Mus musculus	32-37
27669300-4	2016	Therefore, we performed genome-wide transcription profiling experiments with the pdr5 mutant in response to acute CIT, OTA, or combined CIT/OTA exposure.	Citrinin	114-117	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	81-85
27669300-4	2016	Therefore, we performed genome-wide transcription profiling experiments with the pdr5 mutant in response to acute CIT, OTA, or combined CIT/OTA exposure.	Citrinin	136-139	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	81-85
24858409-4	2014	We find that citrinin triggers a fast and dose dependent activation of stress responsive promoters such as GRE2 or SOD2.	Citrinin	13-21	methylglyoxal reductase (NADPH-dependent) GRE2	Saccharomyces cerevisiae S288C	107-111
24930758-0	2014	Disturbed Hsp70 and Hsp27 expression and thiol redox status in porcine kidney PK15 cells provoked by individual and combined ochratoxin A and citrinin treatments.	Citrinin	142-150	heat shock 70 kDa protein 6	Sus scrofa	10-15
24930758-0	2014	Disturbed Hsp70 and Hsp27 expression and thiol redox status in porcine kidney PK15 cells provoked by individual and combined ochratoxin A and citrinin treatments.	Citrinin	142-150	heat shock protein beta-1	Sus scrofa	20-25
26633504-10	2015	Finally, the complex formations of CIT with bovine, porcine, and rat serum albumin were investigated, in order to test the potential species differences of CIT-albumin interactions.	Citrinin	35-38	albumin	Bos taurus	69-82
24858409-5	2014	More specifically, oxidative stress responsive pathways via the transcription factors Yap1 and Skn7 are critically implied in the response to citrinin.	Citrinin	142-150	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	86-90
24858409-4	2014	We find that citrinin triggers a fast and dose dependent activation of stress responsive promoters such as GRE2 or SOD2.	Citrinin	13-21	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	115-119
24858409-5	2014	More specifically, oxidative stress responsive pathways via the transcription factors Yap1 and Skn7 are critically implied in the response to citrinin.	Citrinin	142-150	kinase-regulated stress-responsive transcription factor SKN7	Saccharomyces cerevisiae S288C	95-99
24577378-7	2014	The cytotoxic potency of DH-CIT (IC50 of 320/200 muM) was distinctly lower compared with CIT (IC50 of 70/62 muM) after treatment of V79 cells for 24 and 48 h. Whereas CIT induced a concentration-dependent increase in micronucleus frequencies at concentrations >=30 muM, DH-CIT showed no genotoxic effect up to 300 muM.	Citrinin	28-31	latexin	Homo sapiens	49-52
24577378-10	2014	The effect of CIT and OTA mixtures on induction of micronuclei varied dependent on the used concentrations between additive for low muM concentrations and more-than-additive for high muM concentrations.	Citrinin	14-17	latexin	Homo sapiens	132-135
24577378-10	2014	The effect of CIT and OTA mixtures on induction of micronuclei varied dependent on the used concentrations between additive for low muM concentrations and more-than-additive for high muM concentrations.	Citrinin	14-17	latexin	Homo sapiens	183-186
18767140-0	2009	Activation of JNK and PAK2 is essential for citrinin-induced apoptosis in a human osteoblast cell line.	Citrinin	44-52	mitogen-activated protein kinase 8	Homo sapiens	14-17
24597149-2	2014	The graded doses of citrinin (1, 3 and 5 ppm CIT in feed) in female Wistar rats 10 weeks prior to mating, during mating and during organogenesis resulted in resorptions and post implantation losses, decreased fetal body weights and crown-rump lengths in fetuses of all groups.	Citrinin	20-28	citron rho-interacting serine/threonine kinase	Rattus norvegicus	45-48
24597149-4	2014	The results suggest that CIT has adverse effects on fetal development which may be due to the longer bioavailability of citrinin in the animals.	Citrinin	120-128	citron rho-interacting serine/threonine kinase	Rattus norvegicus	25-28
24052562-7	2013	Furthermore, the heart areas of CTN-exposed embryos demonstrated an elevated levels of aldh1a2 and cspg2 messenger RNA; these 2 cardiac-related genes are known to be involved in retinoic acid (RA) pathway as well as downstream targets of microRNA-138 (miR-138) in zebrafish.	Citrinin	32-35	aldehyde dehydrogenase 1 family, member A2	Danio rerio	87-94
24052562-7	2013	Furthermore, the heart areas of CTN-exposed embryos demonstrated an elevated levels of aldh1a2 and cspg2 messenger RNA; these 2 cardiac-related genes are known to be involved in retinoic acid (RA) pathway as well as downstream targets of microRNA-138 (miR-138) in zebrafish.	Citrinin	32-35	versican a	Danio rerio	99-104
24052562-7	2013	Furthermore, the heart areas of CTN-exposed embryos demonstrated an elevated levels of aldh1a2 and cspg2 messenger RNA; these 2 cardiac-related genes are known to be involved in retinoic acid (RA) pathway as well as downstream targets of microRNA-138 (miR-138) in zebrafish.	Citrinin	32-35	microRNA 138	Danio rerio	238-250
24052562-7	2013	Furthermore, the heart areas of CTN-exposed embryos demonstrated an elevated levels of aldh1a2 and cspg2 messenger RNA; these 2 cardiac-related genes are known to be involved in retinoic acid (RA) pathway as well as downstream targets of microRNA-138 (miR-138) in zebrafish.	Citrinin	32-35	microRNA 138	Danio rerio	252-259
24052562-9	2013	Moreover, overexpression of miR-138 was able to rescue the heart defects generated by CTN.	Citrinin	86-89	microRNA 138	Danio rerio	28-35
24052562-10	2013	These results support the notion that CTN exposure has a severe impact on heart development, affecting heart morphogenesis through the dysregulation of miR-138, RA signaling, and tbx2a.	Citrinin	38-41	microRNA 138	Danio rerio	152-159
24052562-10	2013	These results support the notion that CTN exposure has a severe impact on heart development, affecting heart morphogenesis through the dysregulation of miR-138, RA signaling, and tbx2a.	Citrinin	38-41	T-box transcription factor 2a	Danio rerio	179-184
23893597-5	2013	The combination of CIT + OTA also synergistically suppressed the expression of DNMT-3a and DNMT-3b.	Citrinin	19-22	DNA methyltransferase 3 alpha	Bos taurus	79-86
23893597-5	2013	The combination of CIT + OTA also synergistically suppressed the expression of DNMT-3a and DNMT-3b.	Citrinin	19-22	DNA methyltransferase 3 beta	Bos taurus	91-98
23893597-7	2013	Lastly, MPA and PA slightly reduced HDAC-3 expression, while OTA in combination with CIT, PAT, MPA or PA synergistically suppressed HDAC-3 expression.	Citrinin	85-88	histone deacetylase 3	Bos taurus	132-138
23897301-4	2013	Moreover, the transcription and expression of inducible NO synthase (iNOS) by LPS was suppressed by CIT.	Citrinin	100-103	nitric oxide synthase 2, inducible	Mus musculus	46-67
23897301-4	2013	Moreover, the transcription and expression of inducible NO synthase (iNOS) by LPS was suppressed by CIT.	Citrinin	100-103	nitric oxide synthase 2, inducible	Mus musculus	69-73
23897301-5	2013	These results show that CIT suppressed the LPS-induced NO production and iNOS expression, which contribute to the host protection against invading pathogens.	Citrinin	24-27	nitric oxide synthase 2, inducible	Mus musculus	73-77
23856526-6	2013	In the kidney cortex of gpt delta rats, significant increases in the labeling indices of proliferating cell nuclear antigen (PCNA)-positive cells were observed at all doses of CTN.	Citrinin	176-179	proliferating cell nuclear antigen	Rattus norvegicus	89-123
23856526-6	2013	In the kidney cortex of gpt delta rats, significant increases in the labeling indices of proliferating cell nuclear antigen (PCNA)-positive cells were observed at all doses of CTN.	Citrinin	176-179	proliferating cell nuclear antigen	Rattus norvegicus	125-129
23856526-8	2013	However, histopathological changes were found only in rats treated with the higher dose of CTN, which was consistent with increases in the mRNA expression levels of mitogenic factors associated with tissue damage/regeneration, such as Hgf and Lcn2, at the same dose.	Citrinin	91-94	hepatocyte growth factor	Rattus norvegicus	235-238
23856526-8	2013	However, histopathological changes were found only in rats treated with the higher dose of CTN, which was consistent with increases in the mRNA expression levels of mitogenic factors associated with tissue damage/regeneration, such as Hgf and Lcn2, at the same dose.	Citrinin	91-94	lipocalin 2	Rattus norvegicus	243-247
22564900-4	2012	Western blotting results showed that CTN induced formation of processed p53, caspase-9, and caspase-3 proteins in a dose-dependent manner; CTN also induced a dose-dependent increase in caspase-3 catalytic activity.	Citrinin	37-40	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	72-75
22564900-4	2012	Western blotting results showed that CTN induced formation of processed p53, caspase-9, and caspase-3 proteins in a dose-dependent manner; CTN also induced a dose-dependent increase in caspase-3 catalytic activity.	Citrinin	37-40	caspase 9	Rattus norvegicus	77-86
22564900-4	2012	Western blotting results showed that CTN induced formation of processed p53, caspase-9, and caspase-3 proteins in a dose-dependent manner; CTN also induced a dose-dependent increase in caspase-3 catalytic activity.	Citrinin	37-40	caspase 3	Rattus norvegicus	92-101
22564900-4	2012	Western blotting results showed that CTN induced formation of processed p53, caspase-9, and caspase-3 proteins in a dose-dependent manner; CTN also induced a dose-dependent increase in caspase-3 catalytic activity.	Citrinin	37-40	caspase 3	Rattus norvegicus	185-194
22564900-4	2012	Western blotting results showed that CTN induced formation of processed p53, caspase-9, and caspase-3 proteins in a dose-dependent manner; CTN also induced a dose-dependent increase in caspase-3 catalytic activity.	Citrinin	139-142	caspase 3	Rattus norvegicus	185-194
22564900-6	2012	Taken together, these results suggested that CTN reduced testosterone secretion by inducing apoptosis in rat Leydig cells, a mechanism that might account for CTN stimulation of p53 expression followed by activation of multiple caspases.	Citrinin	45-48	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	177-180
22564900-6	2012	Taken together, these results suggested that CTN reduced testosterone secretion by inducing apoptosis in rat Leydig cells, a mechanism that might account for CTN stimulation of p53 expression followed by activation of multiple caspases.	Citrinin	45-48	caspase 9	Rattus norvegicus	227-235
20937400-6	2010	Herein, we report that CTN significantly suppressed lipopolysaccharide (LPS)/interferon (IFN)-gamma-induced NO production in MES-13 cells, a glomerular mesangial cell line.	Citrinin	23-26	toll-like receptor 4	Mus musculus	72-75
20937400-6	2010	Herein, we report that CTN significantly suppressed lipopolysaccharide (LPS)/interferon (IFN)-gamma-induced NO production in MES-13 cells, a glomerular mesangial cell line.	Citrinin	23-26	interferon gamma	Mus musculus	77-99
20937400-12	2010	Taken together, our data indicated that CTN significantly suppressed NO and iNOS expressions in MES-13 cells via inhibition of the JAK/STAT-1alpha and NF-kappaB signaling pathways.	Citrinin	40-43	nitric oxide synthase 2, inducible	Mus musculus	76-80
20937400-12	2010	Taken together, our data indicated that CTN significantly suppressed NO and iNOS expressions in MES-13 cells via inhibition of the JAK/STAT-1alpha and NF-kappaB signaling pathways.	Citrinin	40-43	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	151-160
18767140-0	2009	Activation of JNK and PAK2 is essential for citrinin-induced apoptosis in a human osteoblast cell line.	Citrinin	44-52	p21 (RAC1) activated kinase 2	Homo sapiens	22-26
18767140-5	2009	CTN induced apoptotic biochemical changes in a human osteoblast cell line, including activation of c-Jun N-terminal kinase (JNK), loss of mitochondrial membrane potential, and caspase-3 and p21-activated protein kinase 2 (PAK2) activation.	Citrinin	0-3	mitogen-activated protein kinase 8	Homo sapiens	99-122
18767140-5	2009	CTN induced apoptotic biochemical changes in a human osteoblast cell line, including activation of c-Jun N-terminal kinase (JNK), loss of mitochondrial membrane potential, and caspase-3 and p21-activated protein kinase 2 (PAK2) activation.	Citrinin	0-3	mitogen-activated protein kinase 8	Homo sapiens	124-127
18767140-5	2009	CTN induced apoptotic biochemical changes in a human osteoblast cell line, including activation of c-Jun N-terminal kinase (JNK), loss of mitochondrial membrane potential, and caspase-3 and p21-activated protein kinase 2 (PAK2) activation.	Citrinin	0-3	caspase 3	Homo sapiens	176-185
18767140-5	2009	CTN induced apoptotic biochemical changes in a human osteoblast cell line, including activation of c-Jun N-terminal kinase (JNK), loss of mitochondrial membrane potential, and caspase-3 and p21-activated protein kinase 2 (PAK2) activation.	Citrinin	0-3	p21 (RAC1) activated kinase 2	Homo sapiens	190-220
18767140-5	2009	CTN induced apoptotic biochemical changes in a human osteoblast cell line, including activation of c-Jun N-terminal kinase (JNK), loss of mitochondrial membrane potential, and caspase-3 and p21-activated protein kinase 2 (PAK2) activation.	Citrinin	0-3	p21 (RAC1) activated kinase 2	Homo sapiens	222-226
18767140-6	2009	Experiments using a JNK-specific inhibitor, SP600125, and antisense oligonucleotides against JNK reduced CTN-induced activation of both JNK and caspase-3 in osteoblasts, indicating that JNK is required for caspase activation in this apoptotic pathway.	Citrinin	105-108	mitogen-activated protein kinase 8	Homo sapiens	20-23
18767140-6	2009	Experiments using a JNK-specific inhibitor, SP600125, and antisense oligonucleotides against JNK reduced CTN-induced activation of both JNK and caspase-3 in osteoblasts, indicating that JNK is required for caspase activation in this apoptotic pathway.	Citrinin	105-108	mitogen-activated protein kinase 8	Homo sapiens	93-96
18767140-6	2009	Experiments using a JNK-specific inhibitor, SP600125, and antisense oligonucleotides against JNK reduced CTN-induced activation of both JNK and caspase-3 in osteoblasts, indicating that JNK is required for caspase activation in this apoptotic pathway.	Citrinin	105-108	mitogen-activated protein kinase 8	Homo sapiens	93-96
18767140-6	2009	Experiments using a JNK-specific inhibitor, SP600125, and antisense oligonucleotides against JNK reduced CTN-induced activation of both JNK and caspase-3 in osteoblasts, indicating that JNK is required for caspase activation in this apoptotic pathway.	Citrinin	105-108	caspase 3	Homo sapiens	144-153
18767140-6	2009	Experiments using a JNK-specific inhibitor, SP600125, and antisense oligonucleotides against JNK reduced CTN-induced activation of both JNK and caspase-3 in osteoblasts, indicating that JNK is required for caspase activation in this apoptotic pathway.	Citrinin	105-108	mitogen-activated protein kinase 8	Homo sapiens	93-96
18767140-8	2009	Moreover, both caspase-3 and PAK2 require activation for CTN-induced apoptosis of osteoblasts.	Citrinin	57-60	caspase 3	Homo sapiens	15-24
18767140-8	2009	Moreover, both caspase-3 and PAK2 require activation for CTN-induced apoptosis of osteoblasts.	Citrinin	57-60	p21 (RAC1) activated kinase 2	Homo sapiens	29-33
18767140-11	2009	On the basis of these results, we propose a signaling cascade model for CTN-induced apoptosis in human osteoblasts involving ROS, JNK, caspases, and PAK2.	Citrinin	72-75	mitogen-activated protein kinase 8	Homo sapiens	130-133
18767140-11	2009	On the basis of these results, we propose a signaling cascade model for CTN-induced apoptosis in human osteoblasts involving ROS, JNK, caspases, and PAK2.	Citrinin	72-75	p21 (RAC1) activated kinase 2	Homo sapiens	149-153
16183218-5	2006	Results of Western blotting showed that CTN induced the formation of processed caspase-3, -6, -7, -9, but not caspase-8, in a dose-dependent manner; CTN also induced a time-dependent increase in caspase-3 catalytic activity.	Citrinin	40-43	caspase 3	Homo sapiens	79-100
18380009-5	2008	Experiments with the embryonic stem cell line, ESC-B5, disclose that CTN induces apoptosis via several mechanisms, including ROS generation, increased cytoplasmic free calcium levels, intracellular nitric oxide production, enhanced Bax/Bcl-2 ratio, loss of mitochondrial membrane potential, cytochrome c release, activation of caspase-9 and caspase-3, and p21-activated protein kinase 2 and c-Jun N-terminal protein kinase activation.	Citrinin	69-72	BCL2-associated X protein	Mus musculus	232-235
18380009-5	2008	Experiments with the embryonic stem cell line, ESC-B5, disclose that CTN induces apoptosis via several mechanisms, including ROS generation, increased cytoplasmic free calcium levels, intracellular nitric oxide production, enhanced Bax/Bcl-2 ratio, loss of mitochondrial membrane potential, cytochrome c release, activation of caspase-9 and caspase-3, and p21-activated protein kinase 2 and c-Jun N-terminal protein kinase activation.	Citrinin	69-72	B cell leukemia/lymphoma 2	Mus musculus	236-241
18380009-5	2008	Experiments with the embryonic stem cell line, ESC-B5, disclose that CTN induces apoptosis via several mechanisms, including ROS generation, increased cytoplasmic free calcium levels, intracellular nitric oxide production, enhanced Bax/Bcl-2 ratio, loss of mitochondrial membrane potential, cytochrome c release, activation of caspase-9 and caspase-3, and p21-activated protein kinase 2 and c-Jun N-terminal protein kinase activation.	Citrinin	69-72	caspase 9	Mus musculus	327-336
18380009-5	2008	Experiments with the embryonic stem cell line, ESC-B5, disclose that CTN induces apoptosis via several mechanisms, including ROS generation, increased cytoplasmic free calcium levels, intracellular nitric oxide production, enhanced Bax/Bcl-2 ratio, loss of mitochondrial membrane potential, cytochrome c release, activation of caspase-9 and caspase-3, and p21-activated protein kinase 2 and c-Jun N-terminal protein kinase activation.	Citrinin	69-72	caspase 3	Mus musculus	341-350
18380009-5	2008	Experiments with the embryonic stem cell line, ESC-B5, disclose that CTN induces apoptosis via several mechanisms, including ROS generation, increased cytoplasmic free calcium levels, intracellular nitric oxide production, enhanced Bax/Bcl-2 ratio, loss of mitochondrial membrane potential, cytochrome c release, activation of caspase-9 and caspase-3, and p21-activated protein kinase 2 and c-Jun N-terminal protein kinase activation.	Citrinin	69-72	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	356-359
18380009-6	2008	Additional studies show that CTN promotes cell death via inactivation of the HSP90/multi-chaperone complex and subsequent degradation of Ras and Raf-1, further inhibiting anti-apoptotic processes such as the Ras-->ERK signal transduction pathway.	Citrinin	29-32	heat shock protein 86, pseudogene 2	Mus musculus	77-82
18380009-6	2008	Additional studies show that CTN promotes cell death via inactivation of the HSP90/multi-chaperone complex and subsequent degradation of Ras and Raf-1, further inhibiting anti-apoptotic processes such as the Ras-->ERK signal transduction pathway.	Citrinin	29-32	v-raf-leukemia viral oncogene 1	Mus musculus	145-150
20111678-5	2009	Resveratrol inhibited CTN-induced ROS generation, activation of JNK, loss of mitochondrial membrane potential (MMP), as well as activation of caspase-9, caspase-3 and PAK2.	Citrinin	22-25	mitogen-activated protein kinase 8	Homo sapiens	64-67
20111678-5	2009	Resveratrol inhibited CTN-induced ROS generation, activation of JNK, loss of mitochondrial membrane potential (MMP), as well as activation of caspase-9, caspase-3 and PAK2.	Citrinin	22-25	p21 (RAC1) activated kinase 2	Homo sapiens	167-171
20111678-6	2009	Moreover, resveratrol and the ROS scavengers, NAC and alpha-tocopherol, abolished CTN-stimulated intracellular oxidative stress and apoptosis.	Citrinin	82-85	X-linked Kx blood group	Homo sapiens	46-49
20111678-7	2009	Active JNK was required for CTN-induced mitochondria-dependent apoptotic biochemical changes, including loss of MMP, and activation of caspases and PAK2.	Citrinin	28-31	mitogen-activated protein kinase 8	Homo sapiens	7-10
20111678-7	2009	Active JNK was required for CTN-induced mitochondria-dependent apoptotic biochemical changes, including loss of MMP, and activation of caspases and PAK2.	Citrinin	28-31	caspase 9	Homo sapiens	135-143
20111678-7	2009	Active JNK was required for CTN-induced mitochondria-dependent apoptotic biochemical changes, including loss of MMP, and activation of caspases and PAK2.	Citrinin	28-31	p21 (RAC1) activated kinase 2	Homo sapiens	148-152
20111678-8	2009	Activation of PAK2 was essential for apoptosis triggered by CTN.	Citrinin	60-63	p21 (RAC1) activated kinase 2	Homo sapiens	14-18
20111678-9	2009	These results collectively demonstrate that CTN stimulates ROS generation and JNK activation for mitochondria-dependent apoptotic signaling in Hep G2 cells, and these apoptotic biochemical events are blocked by pretreatment with resveratrol, which exerts antioxidant effects.	Citrinin	44-47	mitogen-activated protein kinase 8	Homo sapiens	78-81
19594491-10	2009	However, non-toxic doses of citrinin reduced LPS-induced IL-10 production while LPS-induced TNF-alpha production was not similarly reduced by citrinin.	Citrinin	28-36	interleukin 10	Homo sapiens	57-62
19361540-0	2009	Activation of ERK and JNK signaling pathways by mycotoxin citrinin in human cells.	Citrinin	58-66	mitogen-activated protein kinase 3	Homo sapiens	14-17
19361540-0	2009	Activation of ERK and JNK signaling pathways by mycotoxin citrinin in human cells.	Citrinin	58-66	mitogen-activated protein kinase 8	Homo sapiens	22-25
19361540-2	2009	The exposure of human embryonic kidney (HEK293) and HeLa cells to CTN resulted in a dose-dependent increase in the phosphorylation of two major mitogen-activated protein kinases (MAPKs), ERK1/2 and JNK.	Citrinin	66-69	mitogen-activated protein kinase 3	Homo sapiens	187-193
19361540-2	2009	The exposure of human embryonic kidney (HEK293) and HeLa cells to CTN resulted in a dose-dependent increase in the phosphorylation of two major mitogen-activated protein kinases (MAPKs), ERK1/2 and JNK.	Citrinin	66-69	mitogen-activated protein kinase 8	Homo sapiens	198-201
19361540-6	2009	Furthermore, co-exposure of HEK293 cells to CTN and MAPK pathway inhibitors demonstrated that CTN increased the levels of Gadd45 beta mRNA through ERK1/2 signaling pathway and up-regulated the MMP3 transcripts majorly via JNK pathway.	Citrinin	44-47	growth arrest and DNA damage inducible beta	Homo sapiens	122-133
19361540-6	2009	Furthermore, co-exposure of HEK293 cells to CTN and MAPK pathway inhibitors demonstrated that CTN increased the levels of Gadd45 beta mRNA through ERK1/2 signaling pathway and up-regulated the MMP3 transcripts majorly via JNK pathway.	Citrinin	44-47	matrix metallopeptidase 3	Homo sapiens	193-197
19361540-6	2009	Furthermore, co-exposure of HEK293 cells to CTN and MAPK pathway inhibitors demonstrated that CTN increased the levels of Gadd45 beta mRNA through ERK1/2 signaling pathway and up-regulated the MMP3 transcripts majorly via JNK pathway.	Citrinin	94-97	growth arrest and DNA damage inducible beta	Homo sapiens	122-133
19361540-6	2009	Furthermore, co-exposure of HEK293 cells to CTN and MAPK pathway inhibitors demonstrated that CTN increased the levels of Gadd45 beta mRNA through ERK1/2 signaling pathway and up-regulated the MMP3 transcripts majorly via JNK pathway.	Citrinin	94-97	mitogen-activated protein kinase 3	Homo sapiens	147-153
19361540-6	2009	Furthermore, co-exposure of HEK293 cells to CTN and MAPK pathway inhibitors demonstrated that CTN increased the levels of Gadd45 beta mRNA through ERK1/2 signaling pathway and up-regulated the MMP3 transcripts majorly via JNK pathway.	Citrinin	94-97	matrix metallopeptidase 3	Homo sapiens	193-197
19361540-6	2009	Furthermore, co-exposure of HEK293 cells to CTN and MAPK pathway inhibitors demonstrated that CTN increased the levels of Gadd45 beta mRNA through ERK1/2 signaling pathway and up-regulated the MMP3 transcripts majorly via JNK pathway.	Citrinin	94-97	mitogen-activated protein kinase 8	Homo sapiens	222-225
19361540-8	2009	Our results suggest that CTN positively regulates ERK1/2 and JNK pathways as well as their downstream effectors in human cells; activated MAPK pathways are also involved in CTN-induced apoptosis.	Citrinin	25-28	mitogen-activated protein kinase 3	Homo sapiens	50-56
19361540-8	2009	Our results suggest that CTN positively regulates ERK1/2 and JNK pathways as well as their downstream effectors in human cells; activated MAPK pathways are also involved in CTN-induced apoptosis.	Citrinin	25-28	mitogen-activated protein kinase 8	Homo sapiens	61-64
17331071-4	2007	Experiments in embryonic stem cells (ESC-B5) showed that CTN induces apoptosis via ROS (reactive oxygen species) generation, increased Bax/Bcl-2 ratio, loss of MMP (mitochondrial membrane potential), induction of cytochrome c release, and activation of caspase 3.	Citrinin	57-60	BCL2-associated X protein	Mus musculus	135-138
17331071-4	2007	Experiments in embryonic stem cells (ESC-B5) showed that CTN induces apoptosis via ROS (reactive oxygen species) generation, increased Bax/Bcl-2 ratio, loss of MMP (mitochondrial membrane potential), induction of cytochrome c release, and activation of caspase 3.	Citrinin	57-60	B cell leukemia/lymphoma 2	Mus musculus	139-144
17331071-4	2007	Experiments in embryonic stem cells (ESC-B5) showed that CTN induces apoptosis via ROS (reactive oxygen species) generation, increased Bax/Bcl-2 ratio, loss of MMP (mitochondrial membrane potential), induction of cytochrome c release, and activation of caspase 3.	Citrinin	57-60	caspase 3	Mus musculus	253-262
17331071-8	2007	Collectively, these findings show for the first time that CTN induces ROS and mitochondria-dependent apoptotic processes, inhibits Ras-->ERK survival signalling via inactivation of the HSP90/multichaperone complex, and causes developmental injury in vivo.	Citrinin	58-61	mitogen-activated protein kinase 1	Mus musculus	140-143
17331071-8	2007	Collectively, these findings show for the first time that CTN induces ROS and mitochondria-dependent apoptotic processes, inhibits Ras-->ERK survival signalling via inactivation of the HSP90/multichaperone complex, and causes developmental injury in vivo.	Citrinin	58-61	heat shock protein, 3	Mus musculus	188-193
16183218-5	2006	Results of Western blotting showed that CTN induced the formation of processed caspase-3, -6, -7, -9, but not caspase-8, in a dose-dependent manner; CTN also induced a time-dependent increase in caspase-3 catalytic activity.	Citrinin	40-43	caspase 3	Homo sapiens	79-88
16183218-5	2006	Results of Western blotting showed that CTN induced the formation of processed caspase-3, -6, -7, -9, but not caspase-8, in a dose-dependent manner; CTN also induced a time-dependent increase in caspase-3 catalytic activity.	Citrinin	149-152	caspase 3	Homo sapiens	79-88
16183218-8	2006	These findings suggest that CTN induces apoptosis in HL-60 cells by stimulating cytochrome c release followed by activation of multiple caspases, but oxidative stress may not play a role in the apoptotic process.	Citrinin	28-31	cytochrome c, somatic	Homo sapiens	80-92
16183218-8	2006	These findings suggest that CTN induces apoptosis in HL-60 cells by stimulating cytochrome c release followed by activation of multiple caspases, but oxidative stress may not play a role in the apoptotic process.	Citrinin	28-31	caspase 6	Homo sapiens	136-144
34314561-8	2021	This could be confirmed by the enhanced lysosome function, since higher accumulated lysosome distribution were found and LAMP2 was also increased under CTN exposure.	Citrinin	152-155	lysosomal-associated membrane protein 2	Mus musculus	121-126
23605336-6	2005	The results show that citrinin had an antagonistic effect on ochratoxin A induced caspase 3-activation in concentrations of 2.5 and 5 mumol/l.	Citrinin	22-30	caspase 3	Homo sapiens	82-91
23605336-8	2005	The observed decrease in caspase 3-activity was specific for the combination with OTA, since the combination of citrinin with cisplatin did not show any effect.	Citrinin	112-120	caspase 3	Homo sapiens	25-34
15969670-0	2005	The mycotoxins citrinin and gliotoxin differentially affect production of the pro-inflammatory cytokines tumour necrosis factor-alpha and interleukin-6, and the anti-inflammatory cytokine interleukin-10.	Citrinin	15-23	interleukin 6	Homo sapiens	138-151
15969670-0	2005	The mycotoxins citrinin and gliotoxin differentially affect production of the pro-inflammatory cytokines tumour necrosis factor-alpha and interleukin-6, and the anti-inflammatory cytokine interleukin-10.	Citrinin	15-23	interleukin 10	Homo sapiens	188-202
15969670-13	2005	We suggest that low exposure doses of citrinin and gliotoxin (corresponding to less than 100 ng/mL gliotoxin and less than 10 mug/mL citrinin) may inhibit IL-10 and lead to increased risk of an inflammatory response with relative overproduction of TNF-alpha and IL-6.	Citrinin	38-46	interleukin 10	Homo sapiens	155-160
15969670-13	2005	We suggest that low exposure doses of citrinin and gliotoxin (corresponding to less than 100 ng/mL gliotoxin and less than 10 mug/mL citrinin) may inhibit IL-10 and lead to increased risk of an inflammatory response with relative overproduction of TNF-alpha and IL-6.	Citrinin	38-46	tumor necrosis factor	Homo sapiens	248-257
15969670-13	2005	We suggest that low exposure doses of citrinin and gliotoxin (corresponding to less than 100 ng/mL gliotoxin and less than 10 mug/mL citrinin) may inhibit IL-10 and lead to increased risk of an inflammatory response with relative overproduction of TNF-alpha and IL-6.	Citrinin	38-46	interleukin 6	Homo sapiens	262-266
1284957-3	1992	The fungal metabolites, citrinin (4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6- oxo-3H-2-benzopyran-7-carboxylic acid) and DHMI (3,4-dihydro-6-methoxy-3,7-dimethyl-1H-2-benzopyran-8-ol), as well as certain synthetic derivatives, have been evaluated for aldose reductase inhibitory activity using a rat lens enzyme preparation.	Citrinin	24-32	aldo-keto reductase family 1 member B1	Rattus norvegicus	248-264
34153678-6	2021	When (Fe(CN)6) 3-/4- was adopted as indicating probe, the resulting sensor demonstrated a wide linear detection range (i.e. 1 x 10-3-10 ng mL-1) and a low detection limit (i.e. 1 x 10-4 ng mL-1).The sensor was applied to the detection of spiked citrinin in real samples, and satisfactory recovery (i.e. 97% - 110%) was obtained.	Citrinin	245-253	L1 cell adhesion molecule	Mus musculus	139-143
34153678-6	2021	When (Fe(CN)6) 3-/4- was adopted as indicating probe, the resulting sensor demonstrated a wide linear detection range (i.e. 1 x 10-3-10 ng mL-1) and a low detection limit (i.e. 1 x 10-4 ng mL-1).The sensor was applied to the detection of spiked citrinin in real samples, and satisfactory recovery (i.e. 97% - 110%) was obtained.	Citrinin	245-253	L1 cell adhesion molecule	Mus musculus	189-193
12063169-6	2002	Probenecid, piroxicam, octanoate and citrinin inhibited OTA uptake by hOAT4 in a competitive manner (K(i)=44.4-336.4 microM), with the following order of potency: probenecid > piroxicam > octanoate >citrinin.	Citrinin	37-45	solute carrier family 22 member 11	Homo sapiens	70-75
12063169-6	2002	Probenecid, piroxicam, octanoate and citrinin inhibited OTA uptake by hOAT4 in a competitive manner (K(i)=44.4-336.4 microM), with the following order of potency: probenecid > piroxicam > octanoate >citrinin.	Citrinin	208-216	solute carrier family 22 member 11	Homo sapiens	70-75
12112629-0	2002	The mycotoxins citrinin, gliotoxin, and patulin affect interferon-gamma rather than interleukin-4 production in human blood cells.	Citrinin	15-23	interferon gamma	Homo sapiens	55-71
12112629-0	2002	The mycotoxins citrinin, gliotoxin, and patulin affect interferon-gamma rather than interleukin-4 production in human blood cells.	Citrinin	15-23	interleukin 4	Homo sapiens	84-97
12112629-7	2002	The strongest inhibition of cytokine expression was found for IFN-gamma: 8.3 microg/mL citrinin, 34.2 ng/mL gliotoxin, and 64.8 ng/mL patulin caused a 50% inhibition of the IFN-gamma release (50% inhibitory dose, ID(50)).	Citrinin	87-95	interferon gamma	Homo sapiens	62-71
12112629-7	2002	The strongest inhibition of cytokine expression was found for IFN-gamma: 8.3 microg/mL citrinin, 34.2 ng/mL gliotoxin, and 64.8 ng/mL patulin caused a 50% inhibition of the IFN-gamma release (50% inhibitory dose, ID(50)).	Citrinin	87-95	interferon gamma	Homo sapiens	173-182
12112629-8	2002	For IL-4 release the corresponding ID(50) values were 21.6 microg/mL citrinin, 82.8 ng/mL gliotoxin, and 243.2 ng/mL patulin.	Citrinin	69-77	interleukin 4	Homo sapiens	4-8
34322792-4	2022	Therefore, in this study, we aimed to examine the ability of BBP to remove other 12 mycotoxins (including aflatoxin B1, aflatoxin M1, citrinin, dihydrocitrinone, cyclopiazonic acid, deoxynivalenol, ochratoxin A, patulin, sterigmatocystin, zearalanone, alpha-zearalanol, and beta-zearalanol) from different buffers (pH 3.0, 5.0, and 7.0).	Citrinin	134-142	TM2 domain containing 1	Homo sapiens	61-64
34322792-5	2022	Our results showed that BBP can effectively extract citrinin, dihydrocitrinone, sterigmatocystin, zearalanone, alpha-zearalanol, and beta-zearalanol at each pH tested.	Citrinin	52-60	TM2 domain containing 1	Homo sapiens	24-27
35483142-3	2022	Firstly, citrinin mades L02 cell cycle arrest in G2/M phase by inhibition of cyclin B1, cyclin D1, cyclin-dependent kinases 2 (CDK2), and CDK4 expression.	Citrinin	9-17	cyclin dependent kinase 2	Homo sapiens	99-125
35483142-3	2022	Firstly, citrinin mades L02 cell cycle arrest in G2/M phase by inhibition of cyclin B1, cyclin D1, cyclin-dependent kinases 2 (CDK2), and CDK4 expression.	Citrinin	9-17	cyclin dependent kinase 2	Homo sapiens	127-131
35483142-0	2022	The role of ER stress and ATP/AMPK in oxidative stress meditated hepatotoxicity induced by citrinin.	Citrinin	91-99	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	30-34
35483142-3	2022	Firstly, citrinin mades L02 cell cycle arrest in G2/M phase by inhibition of cyclin B1, cyclin D1, cyclin-dependent kinases 2 (CDK2), and CDK4 expression.	Citrinin	9-17	cyclin dependent kinase 4	Homo sapiens	138-142
35483142-3	2022	Firstly, citrinin mades L02 cell cycle arrest in G2/M phase by inhibition of cyclin B1, cyclin D1, cyclin-dependent kinases 2 (CDK2), and CDK4 expression.	Citrinin	9-17	cyclin B1	Homo sapiens	77-86
35483142-4	2022	Secondly, citrinin inhibits proliferation and promotes apoptosis of L02 cells via disruption of mitochondria membrane potential, increase Bax/Bcl-2 ration, activation of caspase-3, 9, and enhance lactate dehydrogenase (LDH) release.	Citrinin	10-18	BCL2 associated X, apoptosis regulator	Homo sapiens	138-141
35483142-3	2022	Firstly, citrinin mades L02 cell cycle arrest in G2/M phase by inhibition of cyclin B1, cyclin D1, cyclin-dependent kinases 2 (CDK2), and CDK4 expression.	Citrinin	9-17	cyclin D1	Homo sapiens	88-97
35483142-4	2022	Secondly, citrinin inhibits proliferation and promotes apoptosis of L02 cells via disruption of mitochondria membrane potential, increase Bax/Bcl-2 ration, activation of caspase-3, 9, and enhance lactate dehydrogenase (LDH) release.	Citrinin	10-18	BCL2 apoptosis regulator	Homo sapiens	142-147
35483142-4	2022	Secondly, citrinin inhibits proliferation and promotes apoptosis of L02 cells via disruption of mitochondria membrane potential, increase Bax/Bcl-2 ration, activation of caspase-3, 9, and enhance lactate dehydrogenase (LDH) release.	Citrinin	10-18	caspase 3	Homo sapiens	170-179
35483142-6	2022	Eventually, pretreatment with NAC, an ROS inhibitor, alleviates citrinin-induced cell cycle G2/M arrest and apoptosis by inhibiting ROS-mediated ER stress; pretreatment with 4-PBA, an ER stress inhibitor, reversed ER stress and p-AMPK; pretreatment with dorsomorphin, an AMPK inhibitor, decreases citrinin-induced cell cycle G2/M arrest and apoptosis.	Citrinin	64-72	synuclein alpha	Homo sapiens	30-33
35483142-6	2022	Eventually, pretreatment with NAC, an ROS inhibitor, alleviates citrinin-induced cell cycle G2/M arrest and apoptosis by inhibiting ROS-mediated ER stress; pretreatment with 4-PBA, an ER stress inhibitor, reversed ER stress and p-AMPK; pretreatment with dorsomorphin, an AMPK inhibitor, decreases citrinin-induced cell cycle G2/M arrest and apoptosis.	Citrinin	64-72	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	230-234
35483142-6	2022	Eventually, pretreatment with NAC, an ROS inhibitor, alleviates citrinin-induced cell cycle G2/M arrest and apoptosis by inhibiting ROS-mediated ER stress; pretreatment with 4-PBA, an ER stress inhibitor, reversed ER stress and p-AMPK; pretreatment with dorsomorphin, an AMPK inhibitor, decreases citrinin-induced cell cycle G2/M arrest and apoptosis.	Citrinin	64-72	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	271-275
35483142-6	2022	Eventually, pretreatment with NAC, an ROS inhibitor, alleviates citrinin-induced cell cycle G2/M arrest and apoptosis by inhibiting ROS-mediated ER stress; pretreatment with 4-PBA, an ER stress inhibitor, reversed ER stress and p-AMPK; pretreatment with dorsomorphin, an AMPK inhibitor, decreases citrinin-induced cell cycle G2/M arrest and apoptosis.	Citrinin	297-305	synuclein alpha	Homo sapiens	30-33
35483142-7	2022	In summary, citrinin induces cell cycle arrest and apoptosis to aggravate liver injury by activating ROS-ER stress-AMPK signaling pathway.	Citrinin	12-20	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	115-119
35448868-4	2022	Treatment with CTN could induce nitric oxide (NO), malondialdehyde (MDA), and reactive oxygen species (ROS) accumulation in mice, accompanied with losses of activities of superoxide dismutase (SOD) and catalase (CAT), levels of glutathione (GSH), and capacities of total antioxidant (T-AOC), resulting in oxidative stress in mice.	Citrinin	15-18	catalase	Mus musculus	212-215
35448868-5	2022	Furthermore, CTN treatment significantly increased Ca2+ accumulation, upregulated protein expressions of ER stress-mediated apoptosis signal protein (glucose regulated protein 78 (GRP78/BIP), C/EBP-homologous protein (CHOP), Caspase-12, and Caspase-3), and induced hepatocyte apoptosis.	Citrinin	13-16	heat shock protein 5	Mus musculus	180-185
35448868-5	2022	Furthermore, CTN treatment significantly increased Ca2+ accumulation, upregulated protein expressions of ER stress-mediated apoptosis signal protein (glucose regulated protein 78 (GRP78/BIP), C/EBP-homologous protein (CHOP), Caspase-12, and Caspase-3), and induced hepatocyte apoptosis.	Citrinin	13-16	heat shock protein 5	Mus musculus	186-189
35448868-5	2022	Furthermore, CTN treatment significantly increased Ca2+ accumulation, upregulated protein expressions of ER stress-mediated apoptosis signal protein (glucose regulated protein 78 (GRP78/BIP), C/EBP-homologous protein (CHOP), Caspase-12, and Caspase-3), and induced hepatocyte apoptosis.	Citrinin	13-16	DNA-damage inducible transcript 3	Mus musculus	192-216
35448868-5	2022	Furthermore, CTN treatment significantly increased Ca2+ accumulation, upregulated protein expressions of ER stress-mediated apoptosis signal protein (glucose regulated protein 78 (GRP78/BIP), C/EBP-homologous protein (CHOP), Caspase-12, and Caspase-3), and induced hepatocyte apoptosis.	Citrinin	13-16	DNA-damage inducible transcript 3	Mus musculus	218-222
35448868-5	2022	Furthermore, CTN treatment significantly increased Ca2+ accumulation, upregulated protein expressions of ER stress-mediated apoptosis signal protein (glucose regulated protein 78 (GRP78/BIP), C/EBP-homologous protein (CHOP), Caspase-12, and Caspase-3), and induced hepatocyte apoptosis.	Citrinin	13-16	caspase 12	Mus musculus	225-235
35448868-5	2022	Furthermore, CTN treatment significantly increased Ca2+ accumulation, upregulated protein expressions of ER stress-mediated apoptosis signal protein (glucose regulated protein 78 (GRP78/BIP), C/EBP-homologous protein (CHOP), Caspase-12, and Caspase-3), and induced hepatocyte apoptosis.	Citrinin	13-16	caspase 3	Mus musculus	241-250
35390240-8	2022	Our findings point to the competition between CTN and OTA for organic anion transporters 1 and 3.	Citrinin	46-49	solute carrier family 22 member 6	Rattus norvegicus	62-96