PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32057845-0	2020	BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activities in vitro and in vivo.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	0-3	poly(ADP-ribose) polymerase 1	Homo sapiens	15-45
33073913-7	2021	Consistently, the fold-reduction in CMV(Y) coat protein accumulation by BTH pretreatment was lower in ago2 than in wild type, pointing to reduced capacity of ago2 to activate BTH-induced CMV(Y) resistance.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	72-75	Argonaute family protein	Arabidopsis thaliana	102-106
33073913-7	2021	Consistently, the fold-reduction in CMV(Y) coat protein accumulation by BTH pretreatment was lower in ago2 than in wild type, pointing to reduced capacity of ago2 to activate BTH-induced CMV(Y) resistance.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	175-178	Argonaute family protein	Arabidopsis thaliana	102-106
33073913-7	2021	Consistently, the fold-reduction in CMV(Y) coat protein accumulation by BTH pretreatment was lower in ago2 than in wild type, pointing to reduced capacity of ago2 to activate BTH-induced CMV(Y) resistance.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	175-178	Argonaute family protein	Arabidopsis thaliana	158-162
32057845-0	2020	BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activities in vitro and in vivo.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	0-3	poly(ADP-ribose) polymerase 1	Homo sapiens	47-53
32057845-2	2020	We designed 2-(2,3,6-tribromo-4,5-dimethoxybenzylidene) hydrazinecarbothioamide (BTH-8) as a novel human PARP (PARP-1) inhibitor with anticancer activities in vitro and in vivo.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	81-86	poly(ADP-ribose) polymerase 1	Homo sapiens	105-109
32057845-2	2020	We designed 2-(2,3,6-tribromo-4,5-dimethoxybenzylidene) hydrazinecarbothioamide (BTH-8) as a novel human PARP (PARP-1) inhibitor with anticancer activities in vitro and in vivo.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	81-86	poly(ADP-ribose) polymerase 1	Homo sapiens	111-117
32057845-4	2020	BTH-8 could bind to PARP-1 with the target affinity [KD (equilibrium dissociation constant) value] of 1.372 muM.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	0-5	poly(ADP-ribose) polymerase 1	Homo sapiens	20-26
32057845-7	2020	BTH-8 also exhibited antitumor activity in vivo, which was achieved by the inhibition of PARP-1.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	0-5	poly(ADP-ribose) polymerase 1	Homo sapiens	89-95
32057845-8	2020	In sum, our study indicates that BTH-8 might be a novel suitable PARP-1 inhibitor to treat human breast cancer.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	33-38	poly(ADP-ribose) polymerase 1	Homo sapiens	65-71
32140425-4	2020	The product BION-50 WG , that contains Acibenzolar-S-methyl (ASM) and silica particles did not present any cytotoxicity but induced a significant increase in the production of the inflammatory cytokine IL-1 beta.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	39-59	interleukin 1 alpha	Homo sapiens	202-211
32140425-4	2020	The product BION-50 WG , that contains Acibenzolar-S-methyl (ASM) and silica particles did not present any cytotoxicity but induced a significant increase in the production of the inflammatory cytokine IL-1 beta.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	61-64	interleukin 1 alpha	Homo sapiens	202-211
31298967-1	2019	Plant activators, including acibenzolar-S-methyl (ASM), are chemical compounds that stimulate plant defense responses to pathogens.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	28-48	H19 imprinted maternally expressed transcript	Homo sapiens	50-53
24755512-6	2014	The genes encoding AED1, a predicted aspartyl protease, and another AED, LEGUME LECTIN-LIKE PROTEIN1 (LLP1), were induced locally and systemically during SAR signaling and locally by salicylic acid (SA) or its functional analog, benzo 1,2,3-thiadiazole-7-carbothioic acid S-methyl ester.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	229-286	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	19-23
28724770-9	2017	Further analysis using a combination of the salicylic acid analogue benzo-(1,2,3)-thiadiazole-7-carbothioic acid S-methyl ester (BTH) and the Ca2+ ionophore A23187 revealed that rgs-CaM functions as an immune receptor that induces salicylic acid signaling by simultaneously perceiving both viral RSS and Ca2+ influx as infection cues, implying its autoactivation.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	68-127	calmodulin 3	Homo sapiens	182-185
18248595-4	2008	High DMR6 transcript levels were also observed in constitutive defense mutants and after treatment with salicylic acid analog BTH, suggesting that DMR6 has a role during plant defense.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	126-129	2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein	Arabidopsis thaliana	5-9
21640586-4	2011	WbiB(Bth) alone produced dTDP-Rha when incubated with dTDP-6dTal.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	5-8	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	25-29
21640586-4	2011	WbiB(Bth) alone produced dTDP-Rha when incubated with dTDP-6dTal.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	5-8	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	54-58
21726155-1	2011	A simple and accurate method for the analysis of acibenzolar-S-methyl (benzo[1,2,3]thiadiazole-7-carbothioic acid-S-methyl ester; CGA 245 704; ASM) and its major conversion product, benzo[1,2,3]thiadiazole-7-carboxylic acid (CGA 210 007; BTC), in soils is presented.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	71-128	H19 imprinted maternally expressed transcript	Homo sapiens	143-146
20109664-19	2009	Synthetic compounds, as for example, acibenzolar-S-methyl (ASM) were developed for use in a novel strategy for crop protection through abiotic induction of SAR.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	37-57	sarcosine dehydrogenase	Homo sapiens	156-159
20109664-19	2009	Synthetic compounds, as for example, acibenzolar-S-methyl (ASM) were developed for use in a novel strategy for crop protection through abiotic induction of SAR.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	59-62	sarcosine dehydrogenase	Homo sapiens	156-159
18248595-4	2008	High DMR6 transcript levels were also observed in constitutive defense mutants and after treatment with salicylic acid analog BTH, suggesting that DMR6 has a role during plant defense.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	126-129	2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein	Arabidopsis thaliana	147-151
11551076-7	2001	This hypothesis is supported by the heightened responsiveness that NIM1 lines exhibited to the SAR-inducing compound benzo(1,2,3)-thiadiazole-7-car-bothioic acid S-methyl ester.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	117-176	regulatory protein (NPR1)	Arabidopsis thaliana	67-71
10394634-2	1999	Resistance against scab (pathogen: Cladosporium cucumerinum) and the accumulation of chitinase were rapidly induced in cucumber plants after treatment with acibenzolar-S-methyl.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	156-176	acidic endochitinase	Cucumis sativus	85-94
34868121-0	2021	The Interaction Between StCDPK14 and StRbohB Contributes to Benzo-(1, 2, 3)-Thiadiazole-7-Carbothioic Acid S-Methyl Ester-Induced Wound Healing of Potato Tubers by Regulating Reactive Oxygen Species Generation.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	60-121	respiratory burst oxidase homolog protein B	Solanum tuberosum	37-44
17619222-4	2007	We found that BTH application significantly increased foliar peroxidase activity, condensed tannin levels, and total phenolic levels but did not alter dihydroxyphenolic levels.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	14-17	peroxidase 42-like	Gossypium hirsutum	61-71
9612947-5	1998	Moreover, the up-regulation of the 32-kDa basic chitinase gene expression in tobacco roots by (1,2,3)-thiadiazole-7-carbothioic acid S-methyl ester (BTH) was less effective in mycorrhizal roots than in nonmycorrhizal controls.	S-methyl benzo(1,2,3)thiadiazole-7-carbothioate	149-152	endochitinase A	Nicotiana tabacum	48-57