PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32764870-14	2020	The expression levels of Nfatc, c-fos, RANK, and MMP9 were significantly decreased in N-Ac-L-Leu-PEI/ODN complex group.	odn	101-104	FBJ osteosarcoma oncogene	Mus musculus	32-37
32827132-1	2021	CpG Oligonucleotides (ODN) are immunomodulatory synthetic oligonucleotides specifically designed to stimulate Toll-like receptor 9.	odn	22-25	toll like receptor 9	Homo sapiens	110-130
33683038-3	2021	This study aimed to show the therapeutic effects of TLR9 antagonist oligonucleotide (ODN) 2088 on liver fibrogenesis.	odn	85-88	toll-like receptor 9	Mus musculus	52-56
33116588-2	2020	The primary ligands for TLR9 receptors are unmethylated cytidine phosphate guanosine (CpG) oligodinucleotides (ODN).	odn	111-114	toll like receptor 9	Homo sapiens	24-28
32764870-14	2020	The expression levels of Nfatc, c-fos, RANK, and MMP9 were significantly decreased in N-Ac-L-Leu-PEI/ODN complex group.	odn	101-104	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	25-30
32764870-14	2020	The expression levels of Nfatc, c-fos, RANK, and MMP9 were significantly decreased in N-Ac-L-Leu-PEI/ODN complex group.	odn	101-104	matrix metallopeptidase 9	Mus musculus	49-53
28888664-3	2019	Interestingly, co-administration of a TLR9 agonist (CpG-deoxyoligonucleotide, ODN) but not of lipopolysaccharide, caused a transient anti-hFIX response.	odn	78-81	toll like receptor 9	Homo sapiens	38-42
28888664-3	2019	Interestingly, co-administration of a TLR9 agonist (CpG-deoxyoligonucleotide, ODN) but not of lipopolysaccharide, caused a transient anti-hFIX response.	odn	78-81	coagulation factor IX	Homo sapiens	138-142
28807725-7	2017	Depletion of maternal Rnf146 using an antisense oligodeoxynucleic acid (ODN) leads to ventralized development and diminished expression of organizer genes.	odn	72-75	ring finger protein 146 S homeolog	Xenopus laevis	22-28
30104216-3	2018	The purified rCpa1 was encapsulated into four types of yeast cell wall particles containing beta-glucan, mannan, and chitin in various proportions or was mixed with an oligonucleotide (ODN) containing two methylated dinucleotide CpG motifs.	odn	185-188	carboxypeptidase A1	Rattus norvegicus	13-18
29291159-2	2018	Despite early promising results, a reliable systemic delivery system for STAT3- targeted oligonucleotide (ODN) drugs is still needed for future clinical translation of anti-STAT3 therapies.	odn	106-109	signal transducer and activator of transcription 3	Homo sapiens	73-78
29291159-2	2018	Despite early promising results, a reliable systemic delivery system for STAT3- targeted oligonucleotide (ODN) drugs is still needed for future clinical translation of anti-STAT3 therapies.	odn	106-109	signal transducer and activator of transcription 3	Homo sapiens	173-178
25799543-5	2015	RESULTS: SHP-1 knock-down by specific antisense oligodesoxynucleotides (AS-Odn) increased cell growth as well as VEGF synthesis and secretion during 24 hours of hypoxia compared to control AS-Odn.	odn	75-78	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	9-14
25820759-2	2015	This study aimed to verify that a single intraoperative transfection of early growth response gene-1 (Egr-1) decoy oligonucleotide (ODN) can suppress vein graft proliferation of VSMCs and intimal hyperplasia.	odn	132-135	early growth response protein 1	Oryctolagus cuniculus	72-100
25820759-2	2015	This study aimed to verify that a single intraoperative transfection of early growth response gene-1 (Egr-1) decoy oligonucleotide (ODN) can suppress vein graft proliferation of VSMCs and intimal hyperplasia.	odn	132-135	early growth response protein 1	Oryctolagus cuniculus	102-107
26003847-2	2015	Here, we report changes in several miRNA regulators of cholinesterases (ChEs) and correspondingly modified ChE activities in intestine, splenocytes and the circulation of mice exposed to both stress and canonical or alternative Toll-Like Receptor 9 (TLR9) oligonucleotide (ODN) aptamer activators or blockers.	odn	273-276	toll-like receptor 9	Mus musculus	250-254
25799543-5	2015	RESULTS: SHP-1 knock-down by specific antisense oligodesoxynucleotides (AS-Odn) increased cell growth as well as VEGF synthesis and secretion during 24 hours of hypoxia compared to control AS-Odn.	odn	75-78	vascular endothelial growth factor A	Homo sapiens	113-117
20665951-2	2010	Phosphorylation of JNK2 was increased in murine B cells following stimulation with either anti-IgM or CpG-1826 oligonucleotide (ODN) alone, with a further increase by a combined stimulation with anti-IgM and CpG-1826 ODN.	odn	128-131	mitogen-activated protein kinase 9	Mus musculus	19-23
25664020-4	2014	This study is to investigate the role and mechanism of CREB antisense oligonucleotide (ODN) in neuropathic pain induced by chronic constriction injury (CCI) in mice.	odn	87-90	cAMP responsive element binding protein 1	Mus musculus	55-59
23475790-1	2013	CpG-oligonucleotide (ODN)-induced TLR9 activation exerts anti-inflammatory effects.	odn	21-24	toll-like receptor 9	Mus musculus	34-38
23052839-4	2013	An inhibition assay using Tbeta4 antisense sulfur-substituted oligodeoxynucleotide (AS S-ODN) in cultured embryonic day 11.0 (E11.0) mandibles showed a significant growth inhibition of the tooth germ.	odn	89-92	thymosin, beta 4, X chromosome	Mus musculus	26-32
23358828-5	2013	In this study, we aimed to suppress STAT-5A and -5B genes in K562 CML cells by siRNA transfection and antisense oligonucleotides (ODN) targeting and then to evaluate apoptosis rate.	odn	130-133	signal transducer and activator of transcription 5A	Homo sapiens	36-51
20945385-5	2011	Leptin-mediated migration and increased integrin expression were attenuated by OBRl receptor antisense oligonucleotide (ODN).	odn	120-123	leptin	Homo sapiens	0-6
25640057-1	2015	AIMS: To test the immobilization of vascular endothelial growth factor (VEGF165 ) on the surface of titanium implants using DNA oligonucleotide (ODN) anchor strands for the ability to enhance periimplant bone formation.	odn	145-148	myotrophin	Rattus norvegicus	57-70
25472474-5	2014	Infection of RAW264.7 cells with B. anthracis spores induced TNF-alpha expression in a multiplicity of infection (MOI)-dependent manner, and this enhancement was attenuated by the toll-like receptor (TLR) 9 inhibitor oligodeoxynucleotide (ODN)2088.	odn	239-242	tumor necrosis factor	Mus musculus	61-70
23460536-5	2013	We have recently developed a new class of inhibitory (CTLA-4) and agonistic (4-1BB and OX-40) ligands composed of short oligonucleotide (ODN) aptamers that exhibited bioactivities comparable or superior to that of antibodies.	odn	137-140	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	54-60
23460536-5	2013	We have recently developed a new class of inhibitory (CTLA-4) and agonistic (4-1BB and OX-40) ligands composed of short oligonucleotide (ODN) aptamers that exhibited bioactivities comparable or superior to that of antibodies.	odn	137-140	TNF receptor superfamily member 9	Homo sapiens	77-82
21745520-2	2011	In the present study, we aimed to evaluate the immune responses of peptide-specific CD8(+) T cells induced by HLA-A*0201 restricted severe acute respiratory syndrome-associated coronavirus (SARS-CoV) S epitopes plus CpG oligodeoxynucleotide (CpG ODN), PolyI:C and R848 as adjuvants.	odn	246-249	CD8a molecule	Homo sapiens	84-87
21745520-2	2011	In the present study, we aimed to evaluate the immune responses of peptide-specific CD8(+) T cells induced by HLA-A*0201 restricted severe acute respiratory syndrome-associated coronavirus (SARS-CoV) S epitopes plus CpG oligodeoxynucleotide (CpG ODN), PolyI:C and R848 as adjuvants.	odn	246-249	major histocompatibility complex, class I, A	Homo sapiens	110-115
21248261-8	2011	TLR 9 agonist CpG deoxyoligonucleotide (ODN) was able to reverse the MCPS-mediated transmembrane activator and calcium-modulator and cyclophilin ligand interactor suppression but could not rescue the Ig secretion in BAFF- or APRIL-stimulated B cells.	odn	40-43	toll-like receptor 9	Mus musculus	0-5
21248261-8	2011	TLR 9 agonist CpG deoxyoligonucleotide (ODN) was able to reverse the MCPS-mediated transmembrane activator and calcium-modulator and cyclophilin ligand interactor suppression but could not rescue the Ig secretion in BAFF- or APRIL-stimulated B cells.	odn	40-43	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	216-220
21248261-8	2011	TLR 9 agonist CpG deoxyoligonucleotide (ODN) was able to reverse the MCPS-mediated transmembrane activator and calcium-modulator and cyclophilin ligand interactor suppression but could not rescue the Ig secretion in BAFF- or APRIL-stimulated B cells.	odn	40-43	tumor necrosis factor (ligand) superfamily, member 13	Mus musculus	225-230
20702733-5	2010	Further, PTO-CpG-ODN counteracted BMP-2- and BMP-6-induced apoptosis of the human myeloma cell lines IH-1 and INA-6, respectively.	odn	17-20	bone morphogenetic protein 2	Homo sapiens	34-39
20702733-5	2010	Further, PTO-CpG-ODN counteracted BMP-2- and BMP-6-induced apoptosis of the human myeloma cell lines IH-1 and INA-6, respectively.	odn	17-20	bone morphogenetic protein 6	Homo sapiens	45-50
20490286-7	2010	In this review, we describe recent achievements in the development of oligonucleotide-(ODN)-based inhibitors of TLR9 and/or TLR7 signaling.	odn	87-90	toll like receptor 9	Homo sapiens	112-116
20490286-7	2010	In this review, we describe recent achievements in the development of oligonucleotide-(ODN)-based inhibitors of TLR9 and/or TLR7 signaling.	odn	87-90	toll like receptor 7	Homo sapiens	124-128
19245434-1	2009	Unmethylated cytosine-phosphorothioate-guanine containing oligodeoxynucleotides (CpG-ODN) is known as a ligand of toll-like receptor 9 (TLR9), which selectively activates type-1 immunity.	odn	85-88	toll-like receptor 9	Mus musculus	114-134
19874040-1	2009	Oxidizing polyazaaromatic Ru(II) complexes containing two TAP ligands (TAP = 1,4,5,8-tetraazaphenanthrene) are able under illumination to cross-link irreversibly the two strands of an oligonucleotide (ODN) duplex by covalent bond formation.	odn	201-204	nuclear RNA export factor 1	Homo sapiens	58-61
19386618-9	2009	By testing this hypothesis we found an increase of apoptosis markers (caspase 3/7, 8, 9, cytosolic cytochrome c, histone associated DNA fragments, apoptotic bodies) when cells were treated with ODN in combination with low doses of staurosporin, a well-known pro-apoptotic stimulus.	odn	194-197	caspase 3	Homo sapiens	70-87
19386618-9	2009	By testing this hypothesis we found an increase of apoptosis markers (caspase 3/7, 8, 9, cytosolic cytochrome c, histone associated DNA fragments, apoptotic bodies) when cells were treated with ODN in combination with low doses of staurosporin, a well-known pro-apoptotic stimulus.	odn	194-197	cytochrome c, somatic	Homo sapiens	99-111
19053028-8	2009	The blockade of MIOX by antisense oligonucleotide (ODN) inhibits high glucose-induced production of alpha-SMA and fibronectin in normal NRK-52E cells.	odn	51-54	myo-inositol oxygenase	Rattus norvegicus	16-20
19053028-8	2009	The blockade of MIOX by antisense oligonucleotide (ODN) inhibits high glucose-induced production of alpha-SMA and fibronectin in normal NRK-52E cells.	odn	51-54	actin gamma 2, smooth muscle	Rattus norvegicus	100-109
19053028-8	2009	The blockade of MIOX by antisense oligonucleotide (ODN) inhibits high glucose-induced production of alpha-SMA and fibronectin in normal NRK-52E cells.	odn	51-54	fibronectin 1	Rattus norvegicus	114-125
19245434-1	2009	Unmethylated cytosine-phosphorothioate-guanine containing oligodeoxynucleotides (CpG-ODN) is known as a ligand of toll-like receptor 9 (TLR9), which selectively activates type-1 immunity.	odn	85-88	toll-like receptor 9	Mus musculus	136-140
18482831-2	2008	Pro-inflammatory genes expression can be down-regulated by using an oligonucleotide (ODN) decoy to NF-kappaB.	odn	85-88	nuclear factor kappa B subunit 1	Homo sapiens	99-108
18985008-9	2008	When synthesized cRNA of hOAT4 along with scrambled- or antisense-oligodeoxynucleotide (ODN) of Xenopus caveolin-1 were co-injected to Xenopus oocytes, the [3H]estrone sulfate uptake was significantly decreased by the co-injection of antisense ODN but not by scrambled ODN.	odn	88-91	caveolin 1 S homeolog	Xenopus laevis	104-114
18985008-9	2008	When synthesized cRNA of hOAT4 along with scrambled- or antisense-oligodeoxynucleotide (ODN) of Xenopus caveolin-1 were co-injected to Xenopus oocytes, the [3H]estrone sulfate uptake was significantly decreased by the co-injection of antisense ODN but not by scrambled ODN.	odn	244-247	solute carrier family 22 member 11	Homo sapiens	25-30
18985008-9	2008	When synthesized cRNA of hOAT4 along with scrambled- or antisense-oligodeoxynucleotide (ODN) of Xenopus caveolin-1 were co-injected to Xenopus oocytes, the [3H]estrone sulfate uptake was significantly decreased by the co-injection of antisense ODN but not by scrambled ODN.	odn	244-247	solute carrier family 22 member 11	Homo sapiens	25-30
18699740-1	2008	Two types of reporters for optical sensing of NF-kappaB p50 protein-oligodeoxyribonucleotide (ODN) duplex interactions were designed and compared in vitro.	odn	94-97	nuclear factor kappa B subunit 1	Homo sapiens	46-59
17890327-5	2007	Decoy oligonucleotides (ODN) studies further demonstrate that AP-1, SP-1, and Smad ODNs abrogate the inhibitory effect of GSH on TGF-beta-induced PAI-1 promoter activity and inhibit TGF-beta-induced expression of endogenous PAI-1.	odn	24-27	transforming growth factor, beta 1	Mus musculus	129-137
18299430-8	2008	Migration of EPCs toward the decidua was retarded when antisense Dkk1 oligonucleotide (ODN) was administered via intrauterine injection in vivo.	odn	87-90	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	65-69
18393256-1	2008	OBJECTIVE: To investigate the inhibitory effect of antisense oligonucleotides (ODN) on dopamine transporter (DAT) in rats and observe the response of the rats to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	odn	79-82	solute carrier family 6 member 3	Rattus norvegicus	87-107
18393256-1	2008	OBJECTIVE: To investigate the inhibitory effect of antisense oligonucleotides (ODN) on dopamine transporter (DAT) in rats and observe the response of the rats to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	odn	79-82	solute carrier family 6 member 3	Rattus norvegicus	109-112
17285590-6	2007	Antisense oligonucleotide (ODN) experiments confirmed that the inhibition of Class III beta-tubulin could at least partially increase paclitaxel-chemosensitivity.	odn	27-30	tubulin beta 3 class III	Homo sapiens	77-99
16737697-1	2006	We describe inhibition of HIV replication by a partially double-stranded 54mer oligodeoxynucleotide, ODN, which consists of an antisense strand targeting the highly conserved polypurine tract, PPT, of HIV, and a second strand, compatible with triple-helix formation.	odn	101-104	tachykinin precursor 1	Homo sapiens	193-196
17371961-4	2007	Our experiments revealed that both synthetic (resiquimod and loxoribine) and natural (ssRNA40) TLR7 ligands abrogate CpG-A- and CpG-C-oligodeoxynucleotide (ODN)-induced IFN-alpha production by human leukocytes.	odn	156-159	toll like receptor 7	Homo sapiens	95-99
16780951-6	2007	BMS-345541, an IKK-2 inhibitor also inhibited the expression of MMP-9 gene induced by CpG-ODN.	odn	90-93	inhibitor of kappaB kinase beta	Mus musculus	15-20
16780951-6	2007	BMS-345541, an IKK-2 inhibitor also inhibited the expression of MMP-9 gene induced by CpG-ODN.	odn	90-93	matrix metallopeptidase 9	Mus musculus	64-69
16650483-3	2006	NC/Nga mouse macrophages produced significantly less TNF-alpha than did BALB/c mouse macrophages in response to CpG oligonucleotide (ODN).	odn	133-136	tumor necrosis factor	Mus musculus	53-62
17593797-3	2007	The SK-Hep-1 HCC cells were transfected with the antisense oligonucleotide (ODN) of MZF-1.	odn	76-79	myeloid zinc finger 1	Homo sapiens	84-89
17593797-7	2007	The growth of SK-Hep-1 HCC cells was inhibited by the 2-5 microM doses of the antisense ODN MZF-1, whereas the control reagent, the sense ODN MZF-1, showed no effects.	odn	88-91	myeloid zinc finger 1	Homo sapiens	92-97
16081598-3	2005	To determine whether CpG DNA can also induce HMGB1 release, the effects of a synthetic CpG oligonucleotide (ODN) on HMGB1 release from RAW 264.7 and J774A.1 cells were assessed by Western blotting of culture supernatants.	odn	108-111	high mobility group box 1	Mus musculus	116-121
16556548-1	2006	G3139 is an antisense oligonucleotide (ODN) that can down-regulate bcl-2, thus potentially acting as a potent anticancer drug.	odn	39-42	BCL2 apoptosis regulator	Homo sapiens	67-72
15806297-6	2005	We found that C6 glioma cells express Ets 1 and can efficiently be transfected with an Ets 1-specific decoy oligodesoxynucleotide (ODN).	odn	131-134	ETS proto-oncogene 1, transcription factor	Rattus norvegicus	38-43
16051514-6	2005	Tca8113 cells displayed significant growth inhibition during the 9-day exposure to ATRA/As-ODN, especially to a combination of As-ODN-hTR and 5muM ATRA, correlating with the inhibition of telomerase expression.	odn	91-94	telomerase RNA component	Homo sapiens	134-137
16180119-1	2005	PURPOSE: CpG-oligodeoxynucleotide (CpG-ODN) plays a critical role in immunity via the augmentation of Th1 and the suppression of Th2 responses.	odn	39-42	negative elongation factor complex member C/D, Th1l	Mus musculus	102-105
16180119-1	2005	PURPOSE: CpG-oligodeoxynucleotide (CpG-ODN) plays a critical role in immunity via the augmentation of Th1 and the suppression of Th2 responses.	odn	39-42	heart and neural crest derivatives expressed 2	Mus musculus	129-132
15806297-6	2005	We found that C6 glioma cells express Ets 1 and can efficiently be transfected with an Ets 1-specific decoy oligodesoxynucleotide (ODN).	odn	131-134	ETS proto-oncogene 1, transcription factor	Rattus norvegicus	87-92
16291254-4	2005	This chapter focuses on the application of iNOS-specific AS-oligodeoxynucleotide (ODN) and highlights some of the pitfalls that must be considered to use this technique effectively.	odn	82-85	nitric oxide synthase 2	Homo sapiens	43-47
15731459-5	2005	Disrupting caveolar structures with beta-cyclodextrin or transfection of VSMC with caveolin-1 antisense oligonucleotides (ODN) prevented PI3-K and Akt activation and cell cycle entry.	odn	122-125	caveolin 1, caveolae protein	Mus musculus	83-93
15731459-5	2005	Disrupting caveolar structures with beta-cyclodextrin or transfection of VSMC with caveolin-1 antisense oligonucleotides (ODN) prevented PI3-K and Akt activation and cell cycle entry.	odn	122-125	thymoma viral proto-oncogene 1	Mus musculus	147-150
15591506-4	2005	AIMS: An alternative approach to blocking CD154/CD40 interactions by employing a CD40 antisense oligonucleotide (ODN) was explored.	odn	113-116	CD40 ligand	Homo sapiens	42-47
15591506-4	2005	AIMS: An alternative approach to blocking CD154/CD40 interactions by employing a CD40 antisense oligonucleotide (ODN) was explored.	odn	113-116	CD40 molecule	Rattus norvegicus	48-52
15591506-4	2005	AIMS: An alternative approach to blocking CD154/CD40 interactions by employing a CD40 antisense oligonucleotide (ODN) was explored.	odn	113-116	CD40 molecule	Rattus norvegicus	81-85
15530647-6	2004	These increases in NF-kappaB p65 protein levels and NF-kappaB DNA binding activity were totally abolished by simultaneous injection of NF-kappaB p65 antisense oligodeoxynucleotide (AS ODN).	odn	184-187	synaptotagmin 1	Rattus norvegicus	29-32
15631802-3	2004	Survivin oligonucleotide (ODN) was transfected into the PANC-1 cells mediated by Lip reagent.	odn	26-29	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	81-84
15530647-6	2004	These increases in NF-kappaB p65 protein levels and NF-kappaB DNA binding activity were totally abolished by simultaneous injection of NF-kappaB p65 antisense oligodeoxynucleotide (AS ODN).	odn	184-187	synaptotagmin 1	Rattus norvegicus	145-148
15449049-1	2004	PURPOSE: The feasibility of intracellular mdr1 mRNA expression detection with radiolabeled antisense oligonucleotide (ODN) was investigated in the murine leukemia cell line, P388/S, and its subclonal, adriamycin-resistant cell line, P388/R.	odn	118-121	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	42-46
15456958-3	2004	We tested this hypothesis by cotransfecting an oligonucleotide (ODN) decoy for CRYBP1 and a luciferase-based reporter vector under the transcriptional control of the Col2a1 promoter linked to the 100-bp enhancer in chondrogenic ATDC5 cells.	odn	64-67	human immunodeficiency virus type I enhancer binding protein 1	Mus musculus	79-85
15610608-5	2004	VLP was able to package and deliver an antisense oligodeoxynucleotide (AS-ODN) against simian virus 40 (SV40) large tumor antigen (LT) into SV40-transformed human fetal glial (SVG) cells in order to inhibit expression of the oncoprotein.	odn	74-77	VHL like	Homo sapiens	0-3
15281085-11	2004	Antisense oligodeoxynucleotides (as-ODN) complementary to c-Fos mRNA at 1 microM significantly inhibited T(3)-induced osteoclast-like cell formation from osteoclast precursors in the absence of stromal cells while sense-ODN did not affect T(3)-induced osteoclast-like cell formation.	odn	36-39	FBJ osteosarcoma oncogene	Mus musculus	58-63
15316505-4	2004	Decoy oligonucleotide (ODN) specific for STAT-1 was applied once locally to the airways of sensitized animals before allergen airway challenges.	odn	23-26	signal transducer and activator of transcription 1	Mus musculus	41-47
14980780-5	2004	Delivery of EGFR antisense ODN via FR-targeted lipid vesicles resulted in a significant down-regulation of EGFR expression in KB cells and cell growth inhibition, far more efficient than that with free ODN or ODN encapsulated in ligand-free lipid vesicles.	odn	27-30	epidermal growth factor receptor	Homo sapiens	12-16
15153554-2	2004	It was shown previously that the blockade of CTGF by antisense oligonucleotide (ODN) inhibits TGF-beta-induced production of fibronectin and type I collagen in cultured renal fibroblasts.	odn	80-83	cellular communication network factor 2	Rattus norvegicus	45-49
15153554-2	2004	It was shown previously that the blockade of CTGF by antisense oligonucleotide (ODN) inhibits TGF-beta-induced production of fibronectin and type I collagen in cultured renal fibroblasts.	odn	80-83	transforming growth factor, beta 1	Rattus norvegicus	94-102
15153554-2	2004	It was shown previously that the blockade of CTGF by antisense oligonucleotide (ODN) inhibits TGF-beta-induced production of fibronectin and type I collagen in cultured renal fibroblasts.	odn	80-83	fibronectin 1	Rattus norvegicus	125-136
15153554-7	2004	CTGF antisense ODN treatment, by contrast, markedly attenuated the induction of CTGF, fibronectin, fibronectin ED-A, and alpha1(I) collagen genes, whereas TGF-beta gene upregulation was not affected.	odn	15-18	cellular communication network factor 2	Rattus norvegicus	0-4
15153554-7	2004	CTGF antisense ODN treatment, by contrast, markedly attenuated the induction of CTGF, fibronectin, fibronectin ED-A, and alpha1(I) collagen genes, whereas TGF-beta gene upregulation was not affected.	odn	15-18	cellular communication network factor 2	Rattus norvegicus	80-84
15153554-7	2004	CTGF antisense ODN treatment, by contrast, markedly attenuated the induction of CTGF, fibronectin, fibronectin ED-A, and alpha1(I) collagen genes, whereas TGF-beta gene upregulation was not affected.	odn	15-18	fibronectin 1	Rattus norvegicus	86-97
15153554-7	2004	CTGF antisense ODN treatment, by contrast, markedly attenuated the induction of CTGF, fibronectin, fibronectin ED-A, and alpha1(I) collagen genes, whereas TGF-beta gene upregulation was not affected.	odn	15-18	fibronectin 1	Rattus norvegicus	99-110
14980780-5	2004	Delivery of EGFR antisense ODN via FR-targeted lipid vesicles resulted in a significant down-regulation of EGFR expression in KB cells and cell growth inhibition, far more efficient than that with free ODN or ODN encapsulated in ligand-free lipid vesicles.	odn	27-30	epidermal growth factor receptor	Homo sapiens	107-111
14980780-5	2004	Delivery of EGFR antisense ODN via FR-targeted lipid vesicles resulted in a significant down-regulation of EGFR expression in KB cells and cell growth inhibition, far more efficient than that with free ODN or ODN encapsulated in ligand-free lipid vesicles.	odn	202-205	epidermal growth factor receptor	Homo sapiens	12-16
15088873-11	2004	Proliferation of an HGF cell line was inhibited by 4 microM c-myc antisense ODN (14% decrease; P < or = 0.006) and 8 microM c-myc antisense ODN (approximately 80% decrease; P < or = 0.0001), but generally not by c-myc sense ODN.	odn	76-79	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	60-65
14704121-1	2004	AIM: To explore the inhibitory effect of antisense oligonucleotide (ODN) to mitogen activated protein kinase(MAPK) on cardiomyocyte hypertrophy induced by angiotensin II (Ang II).	odn	68-71	angiotensinogen	Rattus norvegicus	155-169
14704121-1	2004	AIM: To explore the inhibitory effect of antisense oligonucleotide (ODN) to mitogen activated protein kinase(MAPK) on cardiomyocyte hypertrophy induced by angiotensin II (Ang II).	odn	68-71	angiotensinogen	Rattus norvegicus	171-177
14636724-1	2003	The conjugate of antisense c-raf oligonucleotide (ODN) and poly(ethylene glycol) (PEG) was synthesized for intracellular ODN delivery.	odn	50-53	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	27-32
15088873-11	2004	Proliferation of an HGF cell line was inhibited by 4 microM c-myc antisense ODN (14% decrease; P < or = 0.006) and 8 microM c-myc antisense ODN (approximately 80% decrease; P < or = 0.0001), but generally not by c-myc sense ODN.	odn	143-146	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	127-132
15088873-11	2004	Proliferation of an HGF cell line was inhibited by 4 microM c-myc antisense ODN (14% decrease; P < or = 0.006) and 8 microM c-myc antisense ODN (approximately 80% decrease; P < or = 0.0001), but generally not by c-myc sense ODN.	odn	143-146	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	127-132
12397375-6	2002	Treatment of tooth germ explants of lower incisors with antisense oligodeoxinucleotide (ODN) against dHAND prevented the differentiation of tooth germ cells, including ameloblasts and odontoblasts, the formation of dentin and enamel, and the proliferation of tooth germ cells and increased the apoptosis of tooth germ cells, suggesting that dHAND is essential for these cells during development.	odn	88-91	hand	Drosophila melanogaster	101-106
14596298-2	2003	A P-32 labeled oligonucleotide (ODN) loaded on a polymer coated stent is slowly released in the arterial wall to deliver a therapeutic dose to the target tissue.	odn	32-35	inhibitor of growth family member 2	Homo sapiens	2-6
12917261-2	2003	Inhibition of the synthesis of PKCalpha and beta by specific phosphorothioate-modified antisense oligonucleotides (ODN) resulted in suppression of phosphorylation and activation of Raf-1, mitogen-activated extracellular-regulated kinase kinases and extracellular-regulated kinases in stimulated Jurkat T cells.	odn	115-118	protein kinase C alpha	Homo sapiens	31-39
12917261-2	2003	Inhibition of the synthesis of PKCalpha and beta by specific phosphorothioate-modified antisense oligonucleotides (ODN) resulted in suppression of phosphorylation and activation of Raf-1, mitogen-activated extracellular-regulated kinase kinases and extracellular-regulated kinases in stimulated Jurkat T cells.	odn	115-118	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	181-186
12917261-5	2003	Significant inhibition of high-affinity NF-AT binding and transactivation, IL-2 gene expression, reduction of IL-2 mRNA synthesis, and, most impressively, a complete suppression of IL-2 secretion were observed in PKCbeta antisense ODN-treated cells.	odn	231-234	protein kinase C beta	Homo sapiens	213-220
12891627-1	2003	We have shown recently that inhibition of androgen receptor (AR) expression with an antisense AR oligonucleotide (ODN) inhibits LNCaP prostate tumor cells in vitro as well as in vivo.	odn	114-117	androgen receptor	Homo sapiens	42-59
12891627-1	2003	We have shown recently that inhibition of androgen receptor (AR) expression with an antisense AR oligonucleotide (ODN) inhibits LNCaP prostate tumor cells in vitro as well as in vivo.	odn	114-117	androgen receptor	Homo sapiens	61-63
12891627-1	2003	We have shown recently that inhibition of androgen receptor (AR) expression with an antisense AR oligonucleotide (ODN) inhibits LNCaP prostate tumor cells in vitro as well as in vivo.	odn	114-117	androgen receptor	Homo sapiens	94-96
12594815-9	2003	Antisense oligonucleotide (ODN) complementary to VEGF that inhibited VEGF and VEGF-C expression simultaneously specifically inhibited mesothelioma cell growth.	odn	27-30	vascular endothelial growth factor A	Homo sapiens	49-53
12594815-9	2003	Antisense oligonucleotide (ODN) complementary to VEGF that inhibited VEGF and VEGF-C expression simultaneously specifically inhibited mesothelioma cell growth.	odn	27-30	vascular endothelial growth factor A	Homo sapiens	69-73
12594815-9	2003	Antisense oligonucleotide (ODN) complementary to VEGF that inhibited VEGF and VEGF-C expression simultaneously specifically inhibited mesothelioma cell growth.	odn	27-30	vascular endothelial growth factor C	Homo sapiens	78-84
14581088-1	2003	PURPOSE: Intramural delivery of a P-32 radiolabeled oligonucleotide (ODN) using an infiltrating catheter has been proposed recently to potentially reduce restenosis in coronary arteries and tested on a limited number of human subjects.	odn	69-72	inhibitor of growth family member 2	Homo sapiens	34-38
12643759-1	2003	An antisense oligonucleotide (ODN), c-myb, was covalently conjugated to poly(ethylene glycol) (PEG) via an acid-cleavable phosphoramidate linkage to form a diblock copolymer-like structure.	odn	30-33	MYB proto-oncogene, transcription factor	Homo sapiens	36-41
12691536-1	2003	ISIS 2302, an antisense phosphorothioate oligonucleotide (ODN) targeting human intercellular adhesion molecule-1 (ICAM-1) mRNA, is currently being evaluated for treatment of patients with Crohn"s disease.	odn	58-61	intercellular adhesion molecule 1	Homo sapiens	79-112
12691536-1	2003	ISIS 2302, an antisense phosphorothioate oligonucleotide (ODN) targeting human intercellular adhesion molecule-1 (ICAM-1) mRNA, is currently being evaluated for treatment of patients with Crohn"s disease.	odn	58-61	intercellular adhesion molecule 1	Homo sapiens	114-120
12535162-7	2003	ODN at the dose of 0.1 microg/kg induced a significant decrease of 17.4% in NPY mRNA expression, while the depressing effect was more marked (31.4%) with the highest dose of ODN (1 microg/kg).	odn	0-3	neuropeptide Y	Rattus norvegicus	76-79
12535162-7	2003	ODN at the dose of 0.1 microg/kg induced a significant decrease of 17.4% in NPY mRNA expression, while the depressing effect was more marked (31.4%) with the highest dose of ODN (1 microg/kg).	odn	174-177	neuropeptide Y	Rattus norvegicus	76-79
12397375-6	2002	Treatment of tooth germ explants of lower incisors with antisense oligodeoxinucleotide (ODN) against dHAND prevented the differentiation of tooth germ cells, including ameloblasts and odontoblasts, the formation of dentin and enamel, and the proliferation of tooth germ cells and increased the apoptosis of tooth germ cells, suggesting that dHAND is essential for these cells during development.	odn	88-91	hand	Drosophila melanogaster	341-346
12059028-1	2002	The objectives of this study were to investigate a nuclear factor-kappa B (NFkappaB) decoy oligonucleotide (ODN) strategy on the inhibition of glioblastoma (GBM) cell line growth and to evaluate a poly(DL-lactic-co-glycolic acid) (PLGA) microparticle delivery system for the NFKB decoy ODNs in vitro.	odn	108-111	nuclear factor kappa B subunit 1	Homo sapiens	51-73
12039983-9	2002	In the present experiments, NF-kappaB and AP-1 were involved in the MCP-1-mediated induction of IL-6, as demonstrated by cis element double-stranded (decoy) oligonucleotides (ODN).	odn	175-178	nuclear factor kappa B subunit 1	Homo sapiens	28-37
12039983-9	2002	In the present experiments, NF-kappaB and AP-1 were involved in the MCP-1-mediated induction of IL-6, as demonstrated by cis element double-stranded (decoy) oligonucleotides (ODN).	odn	175-178	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	42-46
12039983-9	2002	In the present experiments, NF-kappaB and AP-1 were involved in the MCP-1-mediated induction of IL-6, as demonstrated by cis element double-stranded (decoy) oligonucleotides (ODN).	odn	175-178	C-C motif chemokine ligand 2	Homo sapiens	68-73
12039983-9	2002	In the present experiments, NF-kappaB and AP-1 were involved in the MCP-1-mediated induction of IL-6, as demonstrated by cis element double-stranded (decoy) oligonucleotides (ODN).	odn	175-178	interleukin 6	Homo sapiens	96-100
12105209-4	2002	Antisense (AS) c-Src oligonucleotide (ODN) treatment reduced IL-18-induced ERK1/2 expression by 32% compared with control, suggesting an upstream role of Src in ERK1/2 activation.	odn	38-41	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	17-20
12105209-4	2002	Antisense (AS) c-Src oligonucleotide (ODN) treatment reduced IL-18-induced ERK1/2 expression by 32% compared with control, suggesting an upstream role of Src in ERK1/2 activation.	odn	38-41	interleukin 18	Homo sapiens	61-66
12105209-4	2002	Antisense (AS) c-Src oligonucleotide (ODN) treatment reduced IL-18-induced ERK1/2 expression by 32% compared with control, suggesting an upstream role of Src in ERK1/2 activation.	odn	38-41	mitogen-activated protein kinase 3	Homo sapiens	75-81
12105209-4	2002	Antisense (AS) c-Src oligonucleotide (ODN) treatment reduced IL-18-induced ERK1/2 expression by 32% compared with control, suggesting an upstream role of Src in ERK1/2 activation.	odn	38-41	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	154-157
12105209-4	2002	Antisense (AS) c-Src oligonucleotide (ODN) treatment reduced IL-18-induced ERK1/2 expression by 32% compared with control, suggesting an upstream role of Src in ERK1/2 activation.	odn	38-41	mitogen-activated protein kinase 3	Homo sapiens	161-167
12059028-1	2002	The objectives of this study were to investigate a nuclear factor-kappa B (NFkappaB) decoy oligonucleotide (ODN) strategy on the inhibition of glioblastoma (GBM) cell line growth and to evaluate a poly(DL-lactic-co-glycolic acid) (PLGA) microparticle delivery system for the NFKB decoy ODNs in vitro.	odn	108-111	nuclear factor kappa B subunit 1	Homo sapiens	75-83
11502877-3	2001	In this work, a phosphorothioated antisense oligonucleotide (ODN), designated ATS-2, was used to suppress cellular synthesis of TS.	odn	61-64	thymidylate synthetase	Homo sapiens	79-81
12022686-1	2002	Previously, we have shown that a phosphorothioate antisense oligonucleotide (ODN) targeted against c-raf RNA (ISIS5132; cRaf-AS) induces apoptosis in human tumor cells.	odn	77-80	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	99-104
11332197-5	2001	In the present study, we found that CD14 antisense oligonucleotide (ODN) can prevent lethal LPS shock in D-galactosamine-sensitized mice.	odn	68-71	CD14 antigen	Mus musculus	36-40
11407478-6	2001	When MeET-4 was treated with antisense TGF-beta1 oligonucleotide (ODN), a significant decrease in both anchorage-dependent and -independent growth was observed.	odn	66-69	transforming growth factor, beta 1	Rattus norvegicus	39-48
11454908-3	2001	Treatment of HeLa cells in vitro with an antisense oligodeoxynucleotide (ODN 83) targeting human TS mRNA reduces TS mRNA and protein levels, inhibits cell proliferation, and sensitizes cells to TS-targeting drugs (Ferguson et al., 1999).	odn	73-76	thymidylate synthetase	Homo sapiens	97-99
11454908-3	2001	Treatment of HeLa cells in vitro with an antisense oligodeoxynucleotide (ODN 83) targeting human TS mRNA reduces TS mRNA and protein levels, inhibits cell proliferation, and sensitizes cells to TS-targeting drugs (Ferguson et al., 1999).	odn	73-76	thymidylate synthetase	Homo sapiens	113-115
11454908-3	2001	Treatment of HeLa cells in vitro with an antisense oligodeoxynucleotide (ODN 83) targeting human TS mRNA reduces TS mRNA and protein levels, inhibits cell proliferation, and sensitizes cells to TS-targeting drugs (Ferguson et al., 1999).	odn	73-76	thymidylate synthetase	Homo sapiens	113-115
11181403-13	2001	AS-ODNs to NHE3 significantly reduced alpha(1)-AR stimulated Na uptake and increases in pH(i); no effect was observed in sense-ODN-treated cells.	odn	3-6	solute carrier family 9 member A3	Homo sapiens	11-15
11247813-4	2001	Furthermore, Y-79 cell uptake of a GRK3 antisense oligonucleotide (ODN), but not of a random or mismatched ODN, reduced GRK3 mRNA expression by approximately 50% without altering GRK2 mRNA expression and inhibited homologous desensitization of CRF1 receptors by approximately 55%.	odn	67-70	G protein-coupled receptor kinase 3	Homo sapiens	35-39
11247813-4	2001	Furthermore, Y-79 cell uptake of a GRK3 antisense oligonucleotide (ODN), but not of a random or mismatched ODN, reduced GRK3 mRNA expression by approximately 50% without altering GRK2 mRNA expression and inhibited homologous desensitization of CRF1 receptors by approximately 55%.	odn	67-70	G protein-coupled receptor kinase 3	Homo sapiens	120-124
11247813-4	2001	Furthermore, Y-79 cell uptake of a GRK3 antisense oligonucleotide (ODN), but not of a random or mismatched ODN, reduced GRK3 mRNA expression by approximately 50% without altering GRK2 mRNA expression and inhibited homologous desensitization of CRF1 receptors by approximately 55%.	odn	67-70	corticotropin releasing hormone receptor 1	Homo sapiens	244-248
11230302-7	2001	Intracerebroventricular injection of AS-ODN-AGT (200 microgram/kg, n=5) significantly decreased SBP (-22+/-6 mm Hg, P<0.05) compared with the sense ODN (n=5) and saline (n=3) groups.	odn	40-43	angiotensinogen	Rattus norvegicus	44-47
12516397-2	2000	METHODS: On the basis of the sequence of c-fos mRNA, two 15-mer phosphorothioated oligodeoxynucleotide(ODN) were synthesized.	odn	103-106	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	41-46
11776656-1	2000	OBJECTIVE: To investigate the thermosensitizing effect of HSP70 antisense oligodeoxynucleolides (ODN) on cervical and ovarian cancer cells.	odn	97-100	heat shock protein family A (Hsp70) member 4	Homo sapiens	58-63
11059864-5	2000	METHODS: Antisense oligonucleotide (ODN) was applied to suppress the production of PKC-alpha in GP7TB cells in vitro and in vivo.	odn	36-39	protein kinase C, alpha	Rattus norvegicus	83-92
10620190-4	2000	METHODS: We used a novel technique, namely, blockade of cytosolic IRF-1 activity with a triethyleneglycol-bridged decoy DNA oligonucleotide (ODN) containing the IRF-1 consensus binding sequences present in the iNOS promoter to inhibit iNOS gene expression.	odn	141-144	interferon regulatory factor 1	Mus musculus	66-71
10620190-4	2000	METHODS: We used a novel technique, namely, blockade of cytosolic IRF-1 activity with a triethyleneglycol-bridged decoy DNA oligonucleotide (ODN) containing the IRF-1 consensus binding sequences present in the iNOS promoter to inhibit iNOS gene expression.	odn	141-144	interferon regulatory factor 1	Mus musculus	161-166
10620190-4	2000	METHODS: We used a novel technique, namely, blockade of cytosolic IRF-1 activity with a triethyleneglycol-bridged decoy DNA oligonucleotide (ODN) containing the IRF-1 consensus binding sequences present in the iNOS promoter to inhibit iNOS gene expression.	odn	141-144	nitric oxide synthase 2, inducible	Mus musculus	210-214
10620190-4	2000	METHODS: We used a novel technique, namely, blockade of cytosolic IRF-1 activity with a triethyleneglycol-bridged decoy DNA oligonucleotide (ODN) containing the IRF-1 consensus binding sequences present in the iNOS promoter to inhibit iNOS gene expression.	odn	141-144	nitric oxide synthase 2, inducible	Mus musculus	235-239
9583688-3	1998	An anti-sense phosphorothioate oligonucleotide (ODN) specifically targeted against c-raf mRNA (Monia et al., 1996a) was used to block c-Raf protein expression in four different cell lines derived from lung, cervical, prostate and colon carcinomas.	odn	48-51	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	83-88
10213872-6	1999	The functional importance of ICAM-1 and its beta2 integrin ligands in ischemia-reperfusion of the kidney has been demonstrated by monoclonal antibody blockade studies, in knockout mice and by treatment with antisense oligodeoxynulceotides (ODN).	odn	240-243	intercellular adhesion molecule 1	Mus musculus	29-35
9920673-2	1999	To investigate whether the rapid induction of mPer1 after light exposure is necessary for light-induced phase shifting, we injected an antisense phosphotioate oligonucleotide (ODN) to mPer1 mRNA into the cerebral ventricle.	odn	176-179	period circadian clock 1	Mus musculus	46-51
9920673-2	1999	To investigate whether the rapid induction of mPer1 after light exposure is necessary for light-induced phase shifting, we injected an antisense phosphotioate oligonucleotide (ODN) to mPer1 mRNA into the cerebral ventricle.	odn	176-179	period circadian clock 1	Mus musculus	184-189
10559476-1	1999	We used an antisense oligonucleotide (ODN) to inhibit laminin (LM) beta1 chain synthesis in mouse embryonic lung explants and cell cultures.	odn	38-41	hemoglobin, beta adult major chain	Mus musculus	67-72
10515383-1	1999	BACKGROUND: We hypothesized that ex vivo donor allograft transfection with antisense oligodeoxynucleotide (AS ODN) would inhibit the expression of intercellular adhesion molecule (ICAM)-1, an important mediator of T-cell adhesion and costimulation, and therefore suppress acute cardiac rejection.	odn	110-113	intercellular adhesion molecule 1	Homo sapiens	147-187
10714212-3	1999	We therefore investigated whether an Ets 1 antisense oligodesoxynucleotide (ODN) blockade effectively inhibits in vivo angiogenesis in the chicken chorioallantois membrane-assay.	odn	76-79	v-ets avian erythroblastosis virus E26 oncogene homolog 1	Gallus gallus	37-42
9583688-3	1998	An anti-sense phosphorothioate oligonucleotide (ODN) specifically targeted against c-raf mRNA (Monia et al., 1996a) was used to block c-Raf protein expression in four different cell lines derived from lung, cervical, prostate and colon carcinomas.	odn	48-51	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	134-139
9659233-2	1998	Synthetic antisense Fc epsilon RI alpha ODN dose-dependently inhibited passive cutaneous anaphylaxis and histamine release from the mouse peritoneal mast cells (MPMC) activated by anti-dinitrophenyl (DNP) IgE.	odn	40-43	Fc receptor, IgE, high affinity I, alpha polypeptide	Mus musculus	20-39
9077539-4	1997	Rabbit vein grafts transfected with AS ODN against proliferating cell nuclear antigen (PCNA) and cell division cycle 2 (cdc2) kinase elaborated significantly more nitric oxide and exhibited greater vasorelaxation to both calcium ionophore and acetylcholine than did untreated or control ODN-treated grafts.	odn	39-42	proliferating cell nuclear antigen	Oryctolagus cuniculus	51-85
9225761-3	1997	Myoblasts were transfected with an anti-sense oligonucleotide (ODN) targeted to the translation initiation site of DM mRNA which resulted in about 76% reduction in the levels of Mt-PK protein.	odn	63-66	DM1 protein kinase	Homo sapiens	178-183
9077539-4	1997	Rabbit vein grafts transfected with AS ODN against proliferating cell nuclear antigen (PCNA) and cell division cycle 2 (cdc2) kinase elaborated significantly more nitric oxide and exhibited greater vasorelaxation to both calcium ionophore and acetylcholine than did untreated or control ODN-treated grafts.	odn	39-42	proliferating cell nuclear antigen	Oryctolagus cuniculus	87-91
9077539-4	1997	Rabbit vein grafts transfected with AS ODN against proliferating cell nuclear antigen (PCNA) and cell division cycle 2 (cdc2) kinase elaborated significantly more nitric oxide and exhibited greater vasorelaxation to both calcium ionophore and acetylcholine than did untreated or control ODN-treated grafts.	odn	39-42	cyclin-dependent kinase 1	Oryctolagus cuniculus	120-124
21544432-1	1996	A 24-mer (antisense) phosphorothioate oligonucleotide (ODN) corresponding to the codons 2-9 of the c-myb gene was evaluated for its effects on the growth of a human Burkitt lymphoma cell line (Raji) in vitro.	odn	55-58	MYB proto-oncogene, transcription factor	Homo sapiens	99-104
8822942-6	1996	Importantly, culture of MM cells with RB antisense, but not RB sense, oligonucleotide (ODN) triggered IL-6 secretion and proliferation in MM cells; however, proliferation was only partially inhibited by neutralizing anti-IL-6 monoclonal antibody (MoAb).	odn	87-90	interleukin 6	Homo sapiens	102-106
8822942-6	1996	Importantly, culture of MM cells with RB antisense, but not RB sense, oligonucleotide (ODN) triggered IL-6 secretion and proliferation in MM cells; however, proliferation was only partially inhibited by neutralizing anti-IL-6 monoclonal antibody (MoAb).	odn	87-90	interleukin 6	Homo sapiens	221-225
8573565-2	1996	A purine-rich triplex-forming oligonucleotide (ODN) forms a stable intermolecular triple helix (triplex) with a homopurine (PR):homopyrimidine (PY) motif in the human c-Ki-ras promoter which contains a 22bp PR:PY region (-328 to -307).	odn	47-50	KRAS proto-oncogene, GTPase	Homo sapiens	167-175
7544471-5	1995	Moreover, ODN inhibited insulin release induced by 0.01 or 1 microM glibenclamide with a similar IC50 (8 to 10 nM) in both isolated pancreatic islets and in HIT-T15 beta-cells.	odn	10-13	insulin	Mesocricetus auratus	24-31
34448456-6	2021	The results indicate that using of TF-antisense (TF-AS) deoxyoligonucleotide (ODN) injection (6 mg/kg), to block TF protein synthesis, significantly restores the elevated level of ALT and WBCs and corrects thrombocytopenia in mice injected with APAP.	odn	78-81	coagulation factor III	Mus musculus	113-115
34785775-9	2022	These in vitro results were confirmed by in mouse xenograft model, combined treatment with ODN and oxaliplatin significantly reduced tumor size and induced Bax upregulation.	odn	91-94	BCL2-associated X protein	Mus musculus	156-159
8390677-4	1993	In contrast, Chol-odN sense to DBI did not affect its expression.	odn	18-21	diazepam binding inhibitor	Mus musculus	31-34
1678655-0	1991	Endogenous anxiogenic peptide, ODN-diazepam-binding inhibitor, and benzodiazepines enhance the production of interleukin-1 and tumor necrosis factor by human monocytes.	odn	31-34	interleukin 1 alpha	Homo sapiens	109-148
33806080-4	2021	In this study, we use synthesized STAT3 decoy oligonucleotides (ODN), which were injected into the tail veins of unilateral ureteral obstruction (UUO) mice, to explore the regulation of autophagy in UUO-induced renal fibrosis.	odn	64-67	signal transducer and activator of transcription 3	Mus musculus	34-39
35584569-13	2022	BAP1 downregulation by siRNA inhibited apoptosis induced by the combined treatment of ODN and oxaliplatin/etoposide.	odn	86-89	BRCA1 associated protein 1	Homo sapiens	0-4