PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19627118-1	2009	Chiral trans-cyclohexanediamine-benzimidazole organocatalysts promote the conjugate addition of a wide variety of 1,3-dicarbonyl compounds such as malonates, ketoesters, and 1,3-diketones to nitroolefins in the presence of TFA as cocatalyst in toluene as solvent at rt or 0 degrees C. The Michael adducts are obtained in high yield and enantioselectivity, using the chiral 2-aminobenzimidazole 7b as hydrogen-bond-mediated chiral organocatalyst.	1,3-dicarbonyl compounds	114-138	coagulation factor III, tissue factor	Homo sapiens	223-226
18491943-2	2008	Treatment of 1,3-dicarbonyl compounds 1 with CS2 in the presence of K2CO3 in DMF at room temperature, followed by stepwise addition of alkyl bromides 2 and methylene active bromides 3, provided via intramolecular cyclization 2,3,4,5-tetrasubstituted thiophenes 4 in yields of 77-94%.	1,3-dicarbonyl compounds	13-37	chorionic somatomammotropin hormone 2	Homo sapiens	45-48
28332678-0	2017	Tandem SN2" nucleophilic substitution/oxidative radical cyclization of aryl substituted allylic alcohols with 1,3-dicarbonyl compounds.	1,3-dicarbonyl compounds	110-134	solute carrier family 38 member 5	Homo sapiens	7-10
12375975-1	2002	Lewis acid Mg(ClO4)2, combined with NBS, in CH3CN or EtOAc provided mild and fast bromination of 1,3-dicarbonyl compounds.	1,3-dicarbonyl compounds	97-121	nibrin	Homo sapiens	36-39
28000372-4	2017	ADMC and ADMP reacted with 1,3-dicarbonyl compounds under mild basic conditions to give 2-diazo-1,3-dicarbonyl compounds in high yields, which were easily isolated in virtue of the high water solubility of the by-products.	1,3-dicarbonyl compounds	27-51	serine palmitoyltransferase small subunit B	Homo sapiens	9-13
18302398-0	2008	Stereoselective synthesis of trisubstituted E-iodoalkenes by indium-catalyzed syn-addition of 1,3-dicarbonyl compounds to 1-iodoalkynes.	1,3-dicarbonyl compounds	94-118	synemin	Homo sapiens	16-19
18302398-1	2008	Indium-catalyzed addition of 1,3-dicarbonyl compounds to 1-iodo-1-alkynes takes place exclusively in a syn-fashion to produce E-iodoalkenes.	1,3-dicarbonyl compounds	29-53	synemin	Homo sapiens	103-106
16887353-0	2006	Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARgamma agonists.	1,3-dicarbonyl compounds	6-30	peroxisome proliferator activated receptor gamma	Mus musculus	73-82
16887353-1	2006	A series of 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles has been synthesized and tested for PPARgamma agonist activity.	1,3-dicarbonyl compounds	12-36	peroxisome proliferator activated receptor gamma	Mus musculus	112-121
15177462-0	2004	Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators.	1,3-dicarbonyl compounds	62-86	peroxisome proliferator activated receptor alpha	Mus musculus	90-99
33253567-0	2021	Synthesis of 1-(Difluoromethyl)alk-1-enes via Palladium-Catalyzed SN2"-Type Substitution Reaction of Difluoromethylated Allylic Phosphates with 1,3-Dicarbonyl Compounds and Imides.	1,3-dicarbonyl compounds	144-168	secretory leukocyte peptidase inhibitor	Homo sapiens	31-36
31525523-1	2019	As restricted CA-4 analogues, a novel series of [1,2,4]triazolo[1,5-a]pyrimidines possessing 3,4,5-trimethoxylphenyl groups has been achieved successfully via an efficient one-pot three-component reaction of 3-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazol-5-amine, 1,3-dicarbonyl compounds and aldehydes.	1,3-dicarbonyl compounds	261-285	carbonic anhydrase 4	Homo sapiens	14-18
31305832-3	2019	The MOF was applied as an efficient bifunctional hydrogen-bonding catalyst for Michael additions of 1,3-dicarbonyl compounds to nitroalkenes in pure water, boosting the catalytic efficiency by up to approximately five times the value afforded by the homogeneous control and exhibiting a highly size-selective catalytic performance and good renewability.	1,3-dicarbonyl compounds	100-124	lysine acetyltransferase 8	Homo sapiens	4-7
30653296-6	2019	In 2013, we developed a unified strategy for the enantioselective synthesis of dihydropyranones and dihydropyridinones by the NHC-catalyzed formal [3 + 3] annulation of 2-bromoenals with readily available 1,3-dicarbonyl compounds or primary vinylogous amides.	1,3-dicarbonyl compounds	205-229	high mobility group nucleosomal binding domain 4	Homo sapiens	126-129
23614840-0	2013	Sc(OTf)3-catalyzed three-component cyclization of arylamines, beta,gamma-unsaturated alpha-ketoesters, and 1,3-dicarbonyl compounds for the synthesis of highly substituted 1,4-dihydropyridines and tetrahydropyridines.	1,3-dicarbonyl compounds	107-131	POU class 5 homeobox 1	Homo sapiens	0-8
23614840-1	2013	A Sc(OTf)3-catalyzed three-component cyclization reaction of arylamines, beta,gamma-unsaturated alpha-ketoesters and 1,3-dicarbonyl compounds was developed to synthesize highly substituted 1,4-dihydropyridines and fused bicyclic tetrahydropyridines carrying a quaternary all-carbon center.	1,3-dicarbonyl compounds	117-141	POU class 5 homeobox 1	Homo sapiens	2-10
22890890-1	2012	A method to prepare alpha,alpha-acyl amino acid derivatives efficiently by Cu(OTf)(2)+1,10-phenanthroline (1,10-phen)-catalyzed amination of 1,3-dicarbonyl compounds with PhI=NSO(2) Ar is described.	1,3-dicarbonyl compounds	141-165	POU class 2 homeobox 2	Homo sapiens	75-84
22890964-1	2012	Reverse regioselectivity: The first catalytic asymmetric C-1 functionalization of 1,3-dicarbonyl compounds by an aldol reaction is described, which regioselectively affords 6-hydroxyhexane-2,4-dione derivatives as the only product with high optical purity of up to 93 % ee.	1,3-dicarbonyl compounds	82-106	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	57-60
22053949-1	2011	beta-1,3-Dicarbonyl aldehydes were synthesized by iron-catalyzed oxidative reactions between 1,3-dicarbonyl compounds and two molecules of tertiary amines in the presence of tert-butyl hydroperoxide (TBHP).	1,3-dicarbonyl compounds	93-117	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	0-8
22428614-1	2012	A novel silver-mediated highly selective oxidative C-H/C-H functionalization of 1,3-dicarbonyl compounds with terminal alkynes for the creation of polysubstituted furans and pyrroles in one step has been demonstrated.	1,3-dicarbonyl compounds	80-104	churchill domain containing 1	Homo sapiens	51-58