PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 25037197-5 2014 DKK-1 levels were significantly lower in diabetic patients receiving compared with those not on aspirin treatment (P=0.008); in the latter, DKK-1 was significantly correlated with 11-dehydro-thromboxane B2, ADMA, and CD40L (rho=0.303. 11-dehydro-thromboxane B2 180-205 dickkopf WNT signaling pathway inhibitor 1 Homo sapiens 140-145 29258006-4 2018 RESULTS: The strongest associations were in PPARGC1B (rs4235745, rs32582, rs10515638) and CNTN4 (rs10510230, rs4684343), these 5 single nucleotide polymorphisms (SNPs) were independently associated with 11-dehydro TxB2 formation. 11-dehydro-thromboxane B2 203-218 PPARG coactivator 1 beta Homo sapiens 44-52 29258006-4 2018 RESULTS: The strongest associations were in PPARGC1B (rs4235745, rs32582, rs10515638) and CNTN4 (rs10510230, rs4684343), these 5 single nucleotide polymorphisms (SNPs) were independently associated with 11-dehydro TxB2 formation. 11-dehydro-thromboxane B2 203-218 contactin 4 Homo sapiens 90-95 28911508-3 2017 OBJECTIVES: This study investigated the association between PCSK9 and CVEs in AF as well as the relationship between PCSK9 and urinary 11-dehydro-thromboxane B2 (11-dh-TxB2), a marker of platelet activation. 11-dehydro-thromboxane B2 135-160 proprotein convertase subtilisin/kexin type 9 Homo sapiens 117-122 27609361-10 2016 GPx3 was inversely associated with urinary 11-dehydro-thromboxane B2 (B -0.337, P<0.001) and serum Nox2 (B: -0.423, P<0.001). 11-dehydro-thromboxane B2 43-68 glutathione peroxidase 3 Homo sapiens 0-4 27098431-5 2016 Residual cyclooxygenase (COX)-1 activity was assessed by measuring serum thromboxane (TX)B2 or urinary 11-dehydro TXB2. 11-dehydro-thromboxane B2 103-118 mitochondrially encoded cytochrome c oxidase I Homo sapiens 9-31 26632534-9 2016 Moreover, multiple regression analysis on pooled data showed that plasma PTX3 was an independent predictor of urinary 11-dehydro-TxB2. 11-dehydro-thromboxane B2 118-133 pentraxin 3 Homo sapiens 73-77 27069632-10 2016 Nevertheless, 11-dehydro-thromboxane B2 and 2,3-dinor-6-keto-PGF1alpha responses to bradykinin were statistically similar during ASA and NHP-554C. 11-dehydro-thromboxane B2 14-39 kininogen 1 Homo sapiens 84-94 15358033-4 2004 RESULTS: Similar to aspirin alone, NCX-4016 effectively inhibited platelet aggregation induced by 0.6 mmol/ arachidonic acid, clot-stimulated thromboxane (TX) B2 generation in whole blood, and urinary excretion of 11-dehydro-TXB2. 11-dehydro-thromboxane B2 214-229 T cell leukemia homeobox 2 Homo sapiens 35-38 15894964-10 2005 M-CSF remained related to 11-dehydro-TXB 2 excretion during both treatment phases (P < .01) suggesting that cytokine-mediated thromboxane A 2 production was not altered by aspirin. 11-dehydro-thromboxane B2 26-42 colony stimulating factor 1 Homo sapiens 0-5 21103664-7 2011 A significant direct correlation was also found between urinary 8-iso-PGF(2alpha) and 11-dehydro-TXB2 before and after iloprost treatment (Rho = 0.695, p < 0.0001). 11-dehydro-thromboxane B2 86-101 placental growth factor Homo sapiens 70-73 20608787-12 2010 Urine 11-dehydro-thromboxane B(2) levels were significantly lower in the ASA and NCX 4016 groups as compared to placebo (p < 0.05). 11-dehydro-thromboxane B2 6-33 T cell leukemia homeobox 2 Homo sapiens 81-84 15604423-11 2005 Moreover, the Cox-2 -765C variant displayed a slightly higher reduction in 11-dTxB2 level on treatment with aspirin. 11-dehydro-thromboxane B2 75-83 mitochondrially encoded cytochrome c oxidase II Homo sapiens 14-19 7749833-6 1995 The reduction in 11-dehydro-TXB2 associated with simvastatin was correlated with the reduction in total cholesterol (r = .81, P < .0001), LDL cholesterol (r = .79, P < .0001), and apolipoprotein B (r = .76, P < .0001) levels. 11-dehydro-thromboxane B2 17-32 apolipoprotein B Homo sapiens 186-202 12810609-8 2003 Statistically significant correlations between IL-6 and both 8-iso-PGF2alpha (r=0.63, P<0.001) and 11-dehydro-TXB2 (r=0.51, P<0.01) were observed. 11-dehydro-thromboxane B2 102-117 interleukin 6 Homo sapiens 47-51 12460234-2 2002 Urinary 11-dehydrothromboxane B2/creatinine (11-DTXB2/Cr) is a marker for platelet activation and vascular constriction, thrombin-antithrombin complex (TAT) for thrombin formation, serum thrombomodulin (TM) for endothelial damage, and beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) for platelet activation and releasing reaction. 11-dehydro-thromboxane B2 8-32 thrombomodulin Homo sapiens 203-205 12460234-2 2002 Urinary 11-dehydrothromboxane B2/creatinine (11-DTXB2/Cr) is a marker for platelet activation and vascular constriction, thrombin-antithrombin complex (TAT) for thrombin formation, serum thrombomodulin (TM) for endothelial damage, and beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) for platelet activation and releasing reaction. 11-dehydro-thromboxane B2 8-32 pro-platelet basic protein Homo sapiens 235-255 12460234-2 2002 Urinary 11-dehydrothromboxane B2/creatinine (11-DTXB2/Cr) is a marker for platelet activation and vascular constriction, thrombin-antithrombin complex (TAT) for thrombin formation, serum thrombomodulin (TM) for endothelial damage, and beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) for platelet activation and releasing reaction. 11-dehydro-thromboxane B2 8-32 pro-platelet basic protein Homo sapiens 257-264 12460234-2 2002 Urinary 11-dehydrothromboxane B2/creatinine (11-DTXB2/Cr) is a marker for platelet activation and vascular constriction, thrombin-antithrombin complex (TAT) for thrombin formation, serum thrombomodulin (TM) for endothelial damage, and beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) for platelet activation and releasing reaction. 11-dehydro-thromboxane B2 8-32 platelet factor 4 Homo sapiens 289-293 9459320-9 1998 In contrast, patients with anti-beta2GPI antibodies IgG at moderate/high titre (group A, n = 14) had higher levels of urinary 11-DH-TXB2 than those at low titre or negative (group B, n = 20) (p = 0.01). 11-dehydro-thromboxane B2 126-136 apolipoprotein H Homo sapiens 32-40 14668348-0 2004 11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils. 11-dehydro-thromboxane B2 0-25 prostaglandin D2 receptor 2 Homo sapiens 150-155 11260423-5 2001 Urinary 11-dehydro-TXB2 directly correlated with plasma vWF and cholesterol. 11-dehydro-thromboxane B2 8-23 von Willebrand factor Homo sapiens 56-59 2136814-2 1990 Its chemically stable hydration product, TXB2, is extensively metabolized through dehydrogenation of the hemiacetal alcohol group at C-11 and beta-oxidation, resulting in the formation of two main enzymatic derivatives (i.e., 11-dehydro-TXB2 and 2,3-dinor-TXB2). 11-dehydro-thromboxane B2 226-241 RNA polymerase III subunit K Homo sapiens 133-137 1506726-4 1992 In this communication, we determined the urinary 11-dehydro TXB2 and 6-keto-PGF1 alpha, which are major metabolites of TXA2 and PGI2, respectively, from early to late pregnancy of normal pregnant women and of women complicated with PIH. 11-dehydro-thromboxane B2 49-64 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 232-235 30605918-6 2019 A direct correlation between urinary excretion of 11-dehydro-thromboxane-B2, a marker of in vivo platelet activation, and circulating PCSK9 levels was reported in patients with atrial fibrillation. 11-dehydro-thromboxane B2 50-75 proprotein convertase subtilisin/kexin type 9 Homo sapiens 134-139 31833075-2 2020 Except for a single oxygen atom, PGD2 is structurally identical to 11-dehydro thromboxane B2 (11d-TxB2 ), a urinary metabolite of the pro-aggregatory platelet activator, thromboxane A2 . 11-dehydro-thromboxane B2 67-92 prostaglandin D2 synthase Homo sapiens 33-37 31833075-2 2020 Except for a single oxygen atom, PGD2 is structurally identical to 11-dehydro thromboxane B2 (11d-TxB2 ), a urinary metabolite of the pro-aggregatory platelet activator, thromboxane A2 . 11-dehydro-thromboxane B2 94-102 prostaglandin D2 synthase Homo sapiens 33-37 31833075-4 2020 Accordingly, we tested whether the cyclopentanone of PGD2 can be expanded to the delta-lactone of 11d-TxB2 in a Baeyer-Villiger oxidation. 11-dehydro-thromboxane B2 98-106 prostaglandin D2 synthase Homo sapiens 53-57 31833075-5 2020 Oxidation of PGD2 with two standard oxidants showed that 11d-TxB2 was formed only with H2 O2 but not with peracetic acid. 11-dehydro-thromboxane B2 57-65 prostaglandin D2 synthase Homo sapiens 13-17 31833075-7 2020 Chemical oxidation of PGD2 to 11d-TxB2 may be a model for an equivalent enzymatic transformation, suggesting a possible link in the metabolism of PGD2 and thromboxane A2 . 11-dehydro-thromboxane B2 30-38 prostaglandin D2 synthase Homo sapiens 22-26 31833075-7 2020 Chemical oxidation of PGD2 to 11d-TxB2 may be a model for an equivalent enzymatic transformation, suggesting a possible link in the metabolism of PGD2 and thromboxane A2 . 11-dehydro-thromboxane B2 30-38 prostaglandin D2 synthase Homo sapiens 146-150 35068281-2 2022 While TxA2 stimulates thromboxane prostanoid (TP) receptors, 11-dehydro-TxB2 is a full agonist of the DP2 (formerly known as the CRTh2) receptors for PGD2. 11-dehydro-thromboxane B2 61-76 prostaglandin D2 receptor 2 Homo sapiens 102-105 35068281-2 2022 While TxA2 stimulates thromboxane prostanoid (TP) receptors, 11-dehydro-TxB2 is a full agonist of the DP2 (formerly known as the CRTh2) receptors for PGD2. 11-dehydro-thromboxane B2 61-76 prostaglandin D2 receptor 2 Homo sapiens 129-134