PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
15358033-4	2004	RESULTS: Similar to aspirin alone, NCX-4016 effectively inhibited platelet aggregation induced by 0.6 mmol/ arachidonic acid, clot-stimulated thromboxane (TX) B2 generation in whole blood, and urinary excretion of 11-dehydro-TXB2.	11-dehydro-thromboxane B2	214-229	T cell leukemia homeobox 2	Homo sapiens	35-38
15604423-11	2005	Moreover, the Cox-2 -765C variant displayed a slightly higher reduction in 11-dTxB2 level on treatment with aspirin.	11-dehydro-thromboxane B2	75-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
12810609-8	2003	Statistically significant correlations between IL-6 and both 8-iso-PGF2alpha (r=0.63, P<0.001) and 11-dehydro-TXB2 (r=0.51, P<0.01) were observed.	11-dehydro-thromboxane B2	102-117	interleukin 6	Homo sapiens	47-51
14668348-0	2004	11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils.	11-dehydro-thromboxane B2	0-25	prostaglandin D2 receptor 2	Homo sapiens	150-155
7749833-6	1995	The reduction in 11-dehydro-TXB2 associated with simvastatin was correlated with the reduction in total cholesterol (r = .81, P < .0001), LDL cholesterol (r = .79, P < .0001), and apolipoprotein B (r = .76, P < .0001) levels.	11-dehydro-thromboxane B2	17-32	apolipoprotein B	Homo sapiens	186-202
12460234-2	2002	Urinary 11-dehydrothromboxane B2/creatinine (11-DTXB2/Cr) is a marker for platelet activation and vascular constriction, thrombin-antithrombin complex (TAT) for thrombin formation, serum thrombomodulin (TM) for endothelial damage, and beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) for platelet activation and releasing reaction.	11-dehydro-thromboxane B2	8-32	thrombomodulin	Homo sapiens	203-205
12460234-2	2002	Urinary 11-dehydrothromboxane B2/creatinine (11-DTXB2/Cr) is a marker for platelet activation and vascular constriction, thrombin-antithrombin complex (TAT) for thrombin formation, serum thrombomodulin (TM) for endothelial damage, and beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) for platelet activation and releasing reaction.	11-dehydro-thromboxane B2	8-32	pro-platelet basic protein	Homo sapiens	235-255
12460234-2	2002	Urinary 11-dehydrothromboxane B2/creatinine (11-DTXB2/Cr) is a marker for platelet activation and vascular constriction, thrombin-antithrombin complex (TAT) for thrombin formation, serum thrombomodulin (TM) for endothelial damage, and beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) for platelet activation and releasing reaction.	11-dehydro-thromboxane B2	8-32	pro-platelet basic protein	Homo sapiens	257-264
12460234-2	2002	Urinary 11-dehydrothromboxane B2/creatinine (11-DTXB2/Cr) is a marker for platelet activation and vascular constriction, thrombin-antithrombin complex (TAT) for thrombin formation, serum thrombomodulin (TM) for endothelial damage, and beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) for platelet activation and releasing reaction.	11-dehydro-thromboxane B2	8-32	platelet factor 4	Homo sapiens	289-293
11260423-5	2001	Urinary 11-dehydro-TXB2 directly correlated with plasma vWF and cholesterol.	11-dehydro-thromboxane B2	8-23	von Willebrand factor	Homo sapiens	56-59
9459320-9	1998	In contrast, patients with anti-beta2GPI antibodies IgG at moderate/high titre (group A, n = 14) had higher levels of urinary 11-DH-TXB2 than those at low titre or negative (group B, n = 20) (p = 0.01).	11-dehydro-thromboxane B2	126-136	apolipoprotein H	Homo sapiens	32-40
31833075-2	2020	Except for a single oxygen atom, PGD2 is structurally identical to 11-dehydro thromboxane B2 (11d-TxB2 ), a urinary metabolite of the pro-aggregatory platelet activator, thromboxane A2 .	11-dehydro-thromboxane B2	67-92	prostaglandin D2 synthase	Homo sapiens	33-37
2136814-2	1990	Its chemically stable hydration product, TXB2, is extensively metabolized through dehydrogenation of the hemiacetal alcohol group at C-11 and beta-oxidation, resulting in the formation of two main enzymatic derivatives (i.e., 11-dehydro-TXB2 and 2,3-dinor-TXB2).	11-dehydro-thromboxane B2	226-241	RNA polymerase III subunit K	Homo sapiens	133-137
1506726-4	1992	In this communication, we determined the urinary 11-dehydro TXB2 and 6-keto-PGF1 alpha, which are major metabolites of TXA2 and PGI2, respectively, from early to late pregnancy of normal pregnant women and of women complicated with PIH.	11-dehydro-thromboxane B2	49-64	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	232-235
35068281-2	2022	While TxA2 stimulates thromboxane prostanoid (TP) receptors, 11-dehydro-TxB2 is a full agonist of the DP2 (formerly known as the CRTh2) receptors for PGD2.	11-dehydro-thromboxane B2	61-76	prostaglandin D2 receptor 2	Homo sapiens	102-105
35068281-2	2022	While TxA2 stimulates thromboxane prostanoid (TP) receptors, 11-dehydro-TxB2 is a full agonist of the DP2 (formerly known as the CRTh2) receptors for PGD2.	11-dehydro-thromboxane B2	61-76	prostaglandin D2 receptor 2	Homo sapiens	129-134
31833075-2	2020	Except for a single oxygen atom, PGD2 is structurally identical to 11-dehydro thromboxane B2 (11d-TxB2 ), a urinary metabolite of the pro-aggregatory platelet activator, thromboxane A2 .	11-dehydro-thromboxane B2	94-102	prostaglandin D2 synthase	Homo sapiens	33-37
31833075-4	2020	Accordingly, we tested whether the cyclopentanone of PGD2 can be expanded to the delta-lactone of 11d-TxB2 in a Baeyer-Villiger oxidation.	11-dehydro-thromboxane B2	98-106	prostaglandin D2 synthase	Homo sapiens	53-57
31833075-5	2020	Oxidation of PGD2 with two standard oxidants showed that 11d-TxB2 was formed only with H2 O2 but not with peracetic acid.	11-dehydro-thromboxane B2	57-65	prostaglandin D2 synthase	Homo sapiens	13-17
31833075-7	2020	Chemical oxidation of PGD2 to 11d-TxB2 may be a model for an equivalent enzymatic transformation, suggesting a possible link in the metabolism of PGD2 and thromboxane A2 .	11-dehydro-thromboxane B2	30-38	prostaglandin D2 synthase	Homo sapiens	22-26
31833075-7	2020	Chemical oxidation of PGD2 to 11d-TxB2 may be a model for an equivalent enzymatic transformation, suggesting a possible link in the metabolism of PGD2 and thromboxane A2 .	11-dehydro-thromboxane B2	30-38	prostaglandin D2 synthase	Homo sapiens	146-150
29258006-4	2018	RESULTS: The strongest associations were in PPARGC1B (rs4235745, rs32582, rs10515638) and CNTN4 (rs10510230, rs4684343), these 5 single nucleotide polymorphisms (SNPs) were independently associated with 11-dehydro TxB2 formation.	11-dehydro-thromboxane B2	203-218	PPARG coactivator 1 beta	Homo sapiens	44-52
30605918-6	2019	A direct correlation between urinary excretion of 11-dehydro-thromboxane-B2, a marker of in vivo platelet activation, and circulating PCSK9 levels was reported in patients with atrial fibrillation.	11-dehydro-thromboxane B2	50-75	proprotein convertase subtilisin/kexin type 9	Homo sapiens	134-139
29258006-4	2018	RESULTS: The strongest associations were in PPARGC1B (rs4235745, rs32582, rs10515638) and CNTN4 (rs10510230, rs4684343), these 5 single nucleotide polymorphisms (SNPs) were independently associated with 11-dehydro TxB2 formation.	11-dehydro-thromboxane B2	203-218	contactin 4	Homo sapiens	90-95
28911508-3	2017	OBJECTIVES: This study investigated the association between PCSK9 and CVEs in AF as well as the relationship between PCSK9 and urinary 11-dehydro-thromboxane B2 (11-dh-TxB2), a marker of platelet activation.	11-dehydro-thromboxane B2	135-160	proprotein convertase subtilisin/kexin type 9	Homo sapiens	117-122
26632534-9	2016	Moreover, multiple regression analysis on pooled data showed that plasma PTX3 was an independent predictor of urinary 11-dehydro-TxB2.	11-dehydro-thromboxane B2	118-133	pentraxin 3	Homo sapiens	73-77
27609361-10	2016	GPx3 was inversely associated with urinary 11-dehydro-thromboxane B2 (B -0.337, P<0.001) and serum Nox2 (B: -0.423, P<0.001).	11-dehydro-thromboxane B2	43-68	glutathione peroxidase 3	Homo sapiens	0-4
27098431-5	2016	Residual cyclooxygenase (COX)-1 activity was assessed by measuring serum thromboxane (TX)B2 or urinary 11-dehydro TXB2.	11-dehydro-thromboxane B2	103-118	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	9-31
27069632-10	2016	Nevertheless, 11-dehydro-thromboxane B2 and 2,3-dinor-6-keto-PGF1alpha responses to bradykinin were statistically similar during ASA and NHP-554C.	11-dehydro-thromboxane B2	14-39	kininogen 1	Homo sapiens	84-94
21103664-7	2011	A significant direct correlation was also found between urinary 8-iso-PGF(2alpha) and 11-dehydro-TXB2 before and after iloprost treatment (Rho = 0.695, p < 0.0001).	11-dehydro-thromboxane B2	86-101	placental growth factor	Homo sapiens	70-73
25037197-5	2014	DKK-1 levels were significantly lower in diabetic patients receiving compared with those not on aspirin treatment (P=0.008); in the latter, DKK-1 was significantly correlated with 11-dehydro-thromboxane B2, ADMA, and CD40L (rho=0.303.	11-dehydro-thromboxane B2	180-205	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	140-145
20608787-12	2010	Urine 11-dehydro-thromboxane B(2) levels were significantly lower in the ASA and NCX 4016 groups as compared to placebo (p < 0.05).	11-dehydro-thromboxane B2	6-33	T cell leukemia homeobox 2	Homo sapiens	81-84
15894964-10	2005	M-CSF remained related to 11-dehydro-TXB 2 excretion during both treatment phases (P < .01) suggesting that cytokine-mediated thromboxane A 2 production was not altered by aspirin.	11-dehydro-thromboxane B2	26-42	colony stimulating factor 1	Homo sapiens	0-5