PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32464330-0	2020	Chelidonine Selectively Inhibits the Growth of Gefitinib-resistant Non-small Cell Lung Cancer Cells through the EGFR-AMPK Pathway.	chelidonine	0-11	epidermal growth factor receptor	Homo sapiens	112-116
33884928-0	2021	Chelidonine Induces Apoptosis via GADD45a-p53 Regulation in Human Pancreatic Cancer Cells.	chelidonine	0-11	growth arrest and DNA damage inducible alpha	Homo sapiens	34-41
33884928-0	2021	Chelidonine Induces Apoptosis via GADD45a-p53 Regulation in Human Pancreatic Cancer Cells.	chelidonine	0-11	tumor protein p53	Homo sapiens	42-45
33884928-4	2021	Annexin-V/propidium iodide staining assay showed that this growth inhibitory effect of chelidonine was induced through apoptosis.	chelidonine	87-98	annexin A5	Homo sapiens	0-9
33884928-7	2021	These results suggest that chelidonine induces pancreatic cancer apoptosis through the p53 and GADD45A pathways.	chelidonine	27-38	tumor protein p53	Homo sapiens	87-90
33884928-7	2021	These results suggest that chelidonine induces pancreatic cancer apoptosis through the p53 and GADD45A pathways.	chelidonine	27-38	growth arrest and DNA damage inducible alpha	Homo sapiens	95-102
32464330-0	2020	Chelidonine Selectively Inhibits the Growth of Gefitinib-resistant Non-small Cell Lung Cancer Cells through the EGFR-AMPK Pathway.	chelidonine	0-11	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	117-121
32464330-4	2020	Chelidonine, extracted from the roots of chelidonium majus, was proved to effectively suppress the growth of NSCLC cells with EGFR double mutation.	chelidonine	0-11	epidermal growth factor receptor	Homo sapiens	126-130
32464330-5	2020	Proteomics analysis indicated that mitochondrial respiratory chain was significantly inhibited by chelidonine, and inhibitor of AMPK effectively blocked the apoptosis induced by chelidonine.	chelidonine	178-189	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	128-132
32464330-6	2020	Molecular dynamics simulations indicated that chelidonine could directly bind to EGFR and showed a much higher binding affinity to EGFRL858R/T790M than EGFRWT, which demonstrated that chelidonine could selectively inhibit the phosphorylation of EGFR in cells with EGFR double-mutantion.	chelidonine	46-57	epidermal growth factor receptor	Homo sapiens	81-85
32464330-6	2020	Molecular dynamics simulations indicated that chelidonine could directly bind to EGFR and showed a much higher binding affinity to EGFRL858R/T790M than EGFRWT, which demonstrated that chelidonine could selectively inhibit the phosphorylation of EGFR in cells with EGFR double-mutantion.	chelidonine	46-57	epidermal growth factor receptor	Homo sapiens	131-135
32464330-6	2020	Molecular dynamics simulations indicated that chelidonine could directly bind to EGFR and showed a much higher binding affinity to EGFRL858R/T790M than EGFRWT, which demonstrated that chelidonine could selectively inhibit the phosphorylation of EGFR in cells with EGFR double-mutantion.	chelidonine	46-57	epidermal growth factor receptor	Homo sapiens	131-135
32464330-6	2020	Molecular dynamics simulations indicated that chelidonine could directly bind to EGFR and showed a much higher binding affinity to EGFRL858R/T790M than EGFRWT, which demonstrated that chelidonine could selectively inhibit the phosphorylation of EGFR in cells with EGFR double-mutantion.	chelidonine	184-195	epidermal growth factor receptor	Homo sapiens	81-85
32464330-6	2020	Molecular dynamics simulations indicated that chelidonine could directly bind to EGFR and showed a much higher binding affinity to EGFRL858R/T790M than EGFRWT, which demonstrated that chelidonine could selectively inhibit the phosphorylation of EGFR in cells with EGFR double-mutantion.	chelidonine	184-195	epidermal growth factor receptor	Homo sapiens	131-135
32464330-6	2020	Molecular dynamics simulations indicated that chelidonine could directly bind to EGFR and showed a much higher binding affinity to EGFRL858R/T790M than EGFRWT, which demonstrated that chelidonine could selectively inhibit the phosphorylation of EGFR in cells with EGFR double-mutantion.	chelidonine	184-195	epidermal growth factor receptor	Homo sapiens	131-135
32156748-0	2020	Targeting NRAS-Mutant Cancers with the Selective STK19 Kinase Inhibitor Chelidonine.	chelidonine	72-83	neuroblastoma ras oncogene	Mus musculus	10-14
32156748-0	2020	Targeting NRAS-Mutant Cancers with the Selective STK19 Kinase Inhibitor Chelidonine.	chelidonine	72-83	serine/threonine kinase 19	Mus musculus	49-54
32156748-10	2020	CONCLUSIONS: Chelidonine suppresses NRAS-mutant cancer cell growth and could have utility as a new treatment for such malignancies.	chelidonine	13-24	neuroblastoma ras oncogene	Mus musculus	36-40
32156748-6	2020	The anti-tumor potency of chelidonine was investigated in vitro and in vivo using a panel of NRAS-mutant and NRAS wild-type cancer cells.	chelidonine	26-37	neuroblastoma ras oncogene	Mus musculus	93-97
32156748-6	2020	The anti-tumor potency of chelidonine was investigated in vitro and in vivo using a panel of NRAS-mutant and NRAS wild-type cancer cells.	chelidonine	26-37	neuroblastoma ras oncogene	Mus musculus	109-113
32156748-7	2020	RESULTS: Chelidonine was identified as a potent and selective inhibitor of STK19 kinase activity.	chelidonine	9-20	serine/threonine kinase 19	Mus musculus	75-80
32156748-8	2020	In vitro, chelidonine treatment inhibited NRAS signaling, leading to reduced cell proliferation and induction of apoptosis in a panel of NRAS-mutant cancer cell lines, including melanoma, liver, lung, and gastric cancer.	chelidonine	10-21	neuroblastoma ras oncogene	Mus musculus	42-46
32156748-8	2020	In vitro, chelidonine treatment inhibited NRAS signaling, leading to reduced cell proliferation and induction of apoptosis in a panel of NRAS-mutant cancer cell lines, including melanoma, liver, lung, and gastric cancer.	chelidonine	10-21	neuroblastoma ras oncogene	Mus musculus	137-141
32156748-9	2020	In vivo, chelidonine suppressed the growth of NRAS-driven tumor cells in nude mice while exhibiting minimal toxicity.	chelidonine	9-20	neuroblastoma ras oncogene	Mus musculus	46-50
31102647-2	2019	Chelidonine (CHE) is a major constituent of the herb and has been reported to be an inhibitor of the cytochrome P450 enzymes (CYP).	chelidonine	0-11	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	101-124
31695406-8	2019	Mechanistically, treatment with chelidonine increased the expression of epithelial indicator E-cadherin, whereas it decreased the expression of mesenchymal indicators N-cadherin and Vimentin.	chelidonine	32-43	cadherin 1	Mus musculus	93-103
31695406-8	2019	Mechanistically, treatment with chelidonine increased the expression of epithelial indicator E-cadherin, whereas it decreased the expression of mesenchymal indicators N-cadherin and Vimentin.	chelidonine	32-43	vimentin	Mus musculus	182-190
32075082-5	2020	Berberine, chelidonine, and chelerythrine significantly decreased the secretion of TNF-alpha in a concentration-dependent manner.	chelidonine	11-22	tumor necrosis factor	Homo sapiens	83-92
31102647-2	2019	Chelidonine (CHE) is a major constituent of the herb and has been reported to be an inhibitor of the cytochrome P450 enzymes (CYP).	chelidonine	0-11	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	126-129
31102647-2	2019	Chelidonine (CHE) is a major constituent of the herb and has been reported to be an inhibitor of the cytochrome P450 enzymes (CYP).	chelidonine	13-16	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	101-124
31102647-2	2019	Chelidonine (CHE) is a major constituent of the herb and has been reported to be an inhibitor of the cytochrome P450 enzymes (CYP).	chelidonine	13-16	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	126-129
25890994-0	2015	Chelidonine suppresses migration and invasion of MDA-MB-231 cells by inhibiting formation of the integrin-linked kinase/PINCH/alpha-parvin complex.	chelidonine	0-11	LIM zinc finger domain containing 1	Homo sapiens	120-125
30368994-10	2019	These findings indicate that CHE acted as a mechanism-based inactivator of CYP2D6 and the observed effects may induce potential drug-drug interactions.	chelidonine	29-32	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	75-81
30257328-5	2018	In addition, pro-inflammatory cytokines induced by LPS, such as TNFalpha and IL-6 were also attenuated by chelidonine.	chelidonine	106-117	tumor necrosis factor	Mus musculus	64-72
30257328-5	2018	In addition, pro-inflammatory cytokines induced by LPS, such as TNFalpha and IL-6 were also attenuated by chelidonine.	chelidonine	106-117	interleukin 6	Mus musculus	77-81
30257328-6	2018	What"s more, LPS-induced activation and degradation of IkappaBalpha followed by translocation of the p65 from the cytoplasm to the nucleus were attenuated by chelidonine.	chelidonine	158-169	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	55-67
30257328-6	2018	What"s more, LPS-induced activation and degradation of IkappaBalpha followed by translocation of the p65 from the cytoplasm to the nucleus were attenuated by chelidonine.	chelidonine	158-169	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	101-104
30257328-7	2018	Furthermore, chelidonine even significantly inhibited TLR4 expression induced by LPS.	chelidonine	13-24	toll-like receptor 4	Mus musculus	54-58
30257328-8	2018	Finally, we verified that chelidonine striking ly decreased serum TNFalpha, IL-6 and PGE2 levels in LPS stimulated mice.	chelidonine	26-37	tumor necrosis factor	Mus musculus	66-74
30257328-8	2018	Finally, we verified that chelidonine striking ly decreased serum TNFalpha, IL-6 and PGE2 levels in LPS stimulated mice.	chelidonine	26-37	interleukin 6	Mus musculus	76-80
30257328-9	2018	Taken together, this study demonstrated that chelidonine may suppressed the LPS-induced inflammatory response both in vitro and in vivo, which was relating to TLR4/NF-kappaB signaling pathway disturbed by chelidonine.	chelidonine	45-56	toll-like receptor 4	Mus musculus	159-163
30257328-9	2018	Taken together, this study demonstrated that chelidonine may suppressed the LPS-induced inflammatory response both in vitro and in vivo, which was relating to TLR4/NF-kappaB signaling pathway disturbed by chelidonine.	chelidonine	45-56	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	164-173
30257328-9	2018	Taken together, this study demonstrated that chelidonine may suppressed the LPS-induced inflammatory response both in vitro and in vivo, which was relating to TLR4/NF-kappaB signaling pathway disturbed by chelidonine.	chelidonine	205-216	toll-like receptor 4	Mus musculus	159-163
30257328-9	2018	Taken together, this study demonstrated that chelidonine may suppressed the LPS-induced inflammatory response both in vitro and in vivo, which was relating to TLR4/NF-kappaB signaling pathway disturbed by chelidonine.	chelidonine	205-216	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	164-173
30281650-9	2018	MCF7 cell growth was arrested completely after three sequential treatments with 0.1 muM chelidonine, each ending after 48 h, while telomere length was reduced to almost 10% of the untreated control.	chelidonine	88-99	latexin	Homo sapiens	84-87
30281650-10	2018	However, treatment with 0.01 muM chelidonine did not have any apparent consequence.	chelidonine	33-44	latexin	Homo sapiens	29-32
29044876-0	2018	Chelidonine inhibits TNF-alpha-induced inflammation by suppressing the NF-kappaB pathways in HCT116 cells.	chelidonine	0-11	tumor necrosis factor	Homo sapiens	21-30
29044876-0	2018	Chelidonine inhibits TNF-alpha-induced inflammation by suppressing the NF-kappaB pathways in HCT116 cells.	chelidonine	0-11	nuclear factor kappa B subunit 1	Homo sapiens	71-80
29044876-4	2018	In this work, we explored the effect of chelidonine on TNF-induced NF-kappaB activation in HCT116 cells.	chelidonine	40-51	tumor necrosis factor	Homo sapiens	55-58
29044876-4	2018	In this work, we explored the effect of chelidonine on TNF-induced NF-kappaB activation in HCT116 cells.	chelidonine	40-51	nuclear factor kappa B subunit 1	Homo sapiens	67-76
29044876-5	2018	We found chelidonine inhibited the phosphorylation and degradation of the inhibitor of NF-kappaB alpha and nuclear translocation of RELA.	chelidonine	9-20	nuclear factor kappa B subunit 1	Homo sapiens	87-96
29044876-5	2018	We found chelidonine inhibited the phosphorylation and degradation of the inhibitor of NF-kappaB alpha and nuclear translocation of RELA.	chelidonine	9-20	RELA proto-oncogene, NF-kB subunit	Homo sapiens	132-136
29044876-6	2018	Furthermore, by inhibiting the activation of NF-kappaB, chelidonine downregulated target genes involved in inflammation, proliferation, and apoptosis.	chelidonine	56-67	nuclear factor kappa B subunit 1	Homo sapiens	45-54
29044876-7	2018	Chelidonine also inhibited mitogen-activated protein kinase pathway activation by blocking c-Jun N-terminal kinase and p38 phosphorylation.	chelidonine	0-11	mitogen-activated protein kinase 14	Homo sapiens	119-122
29044876-8	2018	These results suggest that chelidonine may be a potential therapeutic agent against inflammatory diseases in which inhibition of NF-kappaB activity plays an important role.	chelidonine	27-38	nuclear factor kappa B subunit 1	Homo sapiens	129-138
28479277-10	2017	In comparison, chelidonine and papaverine had no significant interaction with the telomeric quadruplex, while they strongly inhibited telomerase at transcription level of hTERT.	chelidonine	15-26	telomerase reverse transcriptase	Homo sapiens	171-176
26677104-0	2016	Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells.	chelidonine	0-11	sarcoglycan beta	Homo sapiens	65-68
26677104-1	2016	The aim of the present study was to investigate the effect of chelidonine on mitotic slippage and apoptotic-like death in SGC-7901 human gastric cancer cells.	chelidonine	62-73	sarcoglycan beta	Homo sapiens	122-125
26677104-3	2016	Following treatment with chelidonine (10 micromol/l), the ultrastructure changes in SGC-7901, MCF-7 and HepG2 cells were observed by transmission electron microscopy.	chelidonine	25-36	sarcoglycan beta	Homo sapiens	84-87
26677104-4	2016	The effects of chelidonine on G2/M phase arrest and apoptosis of SGC-7901 cells were determined by flow cytometry.	chelidonine	15-26	sarcoglycan beta	Homo sapiens	65-68
26677104-7	2016	The phosphorylation of histone H3 at Ser10 was significantly increased following treatment with chelidonine for 24 h, indicating that chelidonine arrested the SGC-7901 cells in the M phase.	chelidonine	96-107	sarcoglycan beta	Homo sapiens	159-162
26677104-7	2016	The phosphorylation of histone H3 at Ser10 was significantly increased following treatment with chelidonine for 24 h, indicating that chelidonine arrested the SGC-7901 cells in the M phase.	chelidonine	134-145	sarcoglycan beta	Homo sapiens	159-162
26677104-11	2016	In addition, apoptotic morphological changes in multinucleated cells were observed, the apoptosis rates increased gradually with administration of chelidonine in a time-dependent manner and the protein levels of caspase-3 increased significantly between 24 and 72 h. Thus, chelidonine induces mitotic slippage, and apoptotic-like death occurs in SGC-7901 cells undergoing mitotic catastrophe.	chelidonine	147-158	caspase 3	Homo sapiens	212-221
26677104-11	2016	In addition, apoptotic morphological changes in multinucleated cells were observed, the apoptosis rates increased gradually with administration of chelidonine in a time-dependent manner and the protein levels of caspase-3 increased significantly between 24 and 72 h. Thus, chelidonine induces mitotic slippage, and apoptotic-like death occurs in SGC-7901 cells undergoing mitotic catastrophe.	chelidonine	273-284	caspase 3	Homo sapiens	212-221
26677104-11	2016	In addition, apoptotic morphological changes in multinucleated cells were observed, the apoptosis rates increased gradually with administration of chelidonine in a time-dependent manner and the protein levels of caspase-3 increased significantly between 24 and 72 h. Thus, chelidonine induces mitotic slippage, and apoptotic-like death occurs in SGC-7901 cells undergoing mitotic catastrophe.	chelidonine	273-284	sarcoglycan beta	Homo sapiens	346-349
26677104-13	2016	The present study demonstrated that chelidonine induces M phase arrest and mitotic slippage of SGC-7901 human gastric carcinoma cells via downregulating the expression of BubR1, Cdk1 and cyclin B1 proteins.	chelidonine	36-47	sarcoglycan beta	Homo sapiens	95-98
26677104-13	2016	The present study demonstrated that chelidonine induces M phase arrest and mitotic slippage of SGC-7901 human gastric carcinoma cells via downregulating the expression of BubR1, Cdk1 and cyclin B1 proteins.	chelidonine	36-47	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	171-176
26677104-13	2016	The present study demonstrated that chelidonine induces M phase arrest and mitotic slippage of SGC-7901 human gastric carcinoma cells via downregulating the expression of BubR1, Cdk1 and cyclin B1 proteins.	chelidonine	36-47	cyclin dependent kinase 1	Homo sapiens	178-182
26677104-13	2016	The present study demonstrated that chelidonine induces M phase arrest and mitotic slippage of SGC-7901 human gastric carcinoma cells via downregulating the expression of BubR1, Cdk1 and cyclin B1 proteins.	chelidonine	36-47	cyclin B1	Homo sapiens	187-196
26677104-16	2016	The current study proposes that chelidonine induces mitotic slippage and apoptotic-like death of SGC-7901 cells.	chelidonine	32-43	sarcoglycan beta	Homo sapiens	97-100
26481537-0	2015	Chelidonine, a principal isoquinoline alkaloid of Chelidonium majus, attenuates eosinophilic airway inflammation by suppressing IL-4 and eotaxin-2 expression in asthmatic mice.	chelidonine	0-11	interleukin 4	Mus musculus	128-132
26481537-0	2015	Chelidonine, a principal isoquinoline alkaloid of Chelidonium majus, attenuates eosinophilic airway inflammation by suppressing IL-4 and eotaxin-2 expression in asthmatic mice.	chelidonine	0-11	chemokine (C-C motif) ligand 24	Mus musculus	137-146
26481537-4	2015	METHODS: The mice were sensitized to ovalbumin followed by aerosol allergen challenges and determination of chelidonine"s effect on enhanced pause (Penh), pulmonary eosinophilic infiltration, eotaxin-2, interleukin-4 (IL-4), IL-13, OVA-specific IgE production, and several transcription factors.	chelidonine	108-119	chemokine (C-C motif) ligand 24	Mus musculus	192-201
26481537-4	2015	METHODS: The mice were sensitized to ovalbumin followed by aerosol allergen challenges and determination of chelidonine"s effect on enhanced pause (Penh), pulmonary eosinophilic infiltration, eotaxin-2, interleukin-4 (IL-4), IL-13, OVA-specific IgE production, and several transcription factors.	chelidonine	108-119	interleukin 4	Mus musculus	203-216
26481537-4	2015	METHODS: The mice were sensitized to ovalbumin followed by aerosol allergen challenges and determination of chelidonine"s effect on enhanced pause (Penh), pulmonary eosinophilic infiltration, eotaxin-2, interleukin-4 (IL-4), IL-13, OVA-specific IgE production, and several transcription factors.	chelidonine	108-119	interleukin 4	Mus musculus	218-222
26481537-4	2015	METHODS: The mice were sensitized to ovalbumin followed by aerosol allergen challenges and determination of chelidonine"s effect on enhanced pause (Penh), pulmonary eosinophilic infiltration, eotaxin-2, interleukin-4 (IL-4), IL-13, OVA-specific IgE production, and several transcription factors.	chelidonine	108-119	interleukin 13	Mus musculus	225-230
26481537-5	2015	RESULT: Chelidonine strongly suppressed airway eosinophilia, expression of eotaxin-2, IL-4, and IL-13 cytokine production in bronchoalveolar lavage fluid (BALF).	chelidonine	8-19	chemokine (C-C motif) ligand 24	Mus musculus	75-84
26481537-5	2015	RESULT: Chelidonine strongly suppressed airway eosinophilia, expression of eotaxin-2, IL-4, and IL-13 cytokine production in bronchoalveolar lavage fluid (BALF).	chelidonine	8-19	interleukin 4	Mus musculus	86-90
26481537-5	2015	RESULT: Chelidonine strongly suppressed airway eosinophilia, expression of eotaxin-2, IL-4, and IL-13 cytokine production in bronchoalveolar lavage fluid (BALF).	chelidonine	8-19	interleukin 13	Mus musculus	96-101
26481537-8	2015	CONCLUSIONS: Chelidonine has profound inhibitory effects on airway inflammation and this effect is caused by suppression of IL-4, eotaxin-2, and OVA-specific IgE production through the STAT6 and Foxp3 pathways.	chelidonine	13-24	interleukin 4	Mus musculus	124-128
26481537-8	2015	CONCLUSIONS: Chelidonine has profound inhibitory effects on airway inflammation and this effect is caused by suppression of IL-4, eotaxin-2, and OVA-specific IgE production through the STAT6 and Foxp3 pathways.	chelidonine	13-24	chemokine (C-C motif) ligand 24	Mus musculus	130-139
26481537-8	2015	CONCLUSIONS: Chelidonine has profound inhibitory effects on airway inflammation and this effect is caused by suppression of IL-4, eotaxin-2, and OVA-specific IgE production through the STAT6 and Foxp3 pathways.	chelidonine	13-24	signal transducer and activator of transcription 6	Mus musculus	185-190
26481537-8	2015	CONCLUSIONS: Chelidonine has profound inhibitory effects on airway inflammation and this effect is caused by suppression of IL-4, eotaxin-2, and OVA-specific IgE production through the STAT6 and Foxp3 pathways.	chelidonine	13-24	forkhead box P3	Mus musculus	195-200
30368994-0	2019	Mechanism-based inactivation of cytochrome P450 2D6 by chelidonine.	chelidonine	55-66	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	32-51
30257328-0	2018	Chelidonine suppresses LPS-Induced production of inflammatory mediators through the inhibitory of the TLR4/NF-kappaB signaling pathway in RAW264.7 macrophages.	chelidonine	0-11	toll-like receptor 4	Mus musculus	102-106
30257328-0	2018	Chelidonine suppresses LPS-Induced production of inflammatory mediators through the inhibitory of the TLR4/NF-kappaB signaling pathway in RAW264.7 macrophages.	chelidonine	0-11	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	107-116
30257328-4	2018	Firstly, we found that chelidonine significantly suppressed LPS-induced the production of NO and PGE2, as well as iNOS and COX-2 mRNA and protein expression.	chelidonine	23-34	nitric oxide synthase 2, inducible	Mus musculus	114-118
30257328-4	2018	Firstly, we found that chelidonine significantly suppressed LPS-induced the production of NO and PGE2, as well as iNOS and COX-2 mRNA and protein expression.	chelidonine	23-34	cytochrome c oxidase II, mitochondrial	Mus musculus	123-128
30127902-4	2018	Chelidonine suppressed the growth of all tested HNSCC cell lines, including a paclitaxel-resistant and P-glycoprotein (MDR1) overexpressing cell line, but not in a clear dose-dependent manner.	chelidonine	0-11	ATP binding cassette subfamily B member 1	Homo sapiens	103-117
30127902-4	2018	Chelidonine suppressed the growth of all tested HNSCC cell lines, including a paclitaxel-resistant and P-glycoprotein (MDR1) overexpressing cell line, but not in a clear dose-dependent manner.	chelidonine	0-11	ATP binding cassette subfamily B member 1	Homo sapiens	119-123
30127902-7	2018	Based on a spheroid invasion model chelidonine suppressed invasion of FaDu cells effectively on gelatin, fibronectin, collagen I, laminin and Matrigel .	chelidonine	35-46	fibronectin 1	Homo sapiens	105-116
30127902-10	2018	Expression analysis revealed an upregulation of the xenobiotic metabolism genes CYP1A1 and MDR1 by chelidonine.	chelidonine	99-110	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	80-86
30127902-10	2018	Expression analysis revealed an upregulation of the xenobiotic metabolism genes CYP1A1 and MDR1 by chelidonine.	chelidonine	99-110	ATP binding cassette subfamily B member 1	Homo sapiens	91-95
27420038-3	2016	Sanguinarine, chelerythrine and chelidonine depolymerized the microtubule network in living cancer cells (Hela cells and human osteosarcoma U2OS cells) and inhibited tubulin polymerization in vitro with IC50 values of 48.41 +- 3.73, 206.39 +- 4.20 and 34.51 +- 9.47 muM, respectively.	chelidonine	32-43	latexin	Homo sapiens	266-269
27420038-4	2016	However, sanguinarine and chelerythrine did not arrest the cell cycle while 2.5 muM chelidonine arrested the cell cycle in the G2/M phase with 88.27% +- 0.99% of the cells in this phase.	chelidonine	84-95	latexin	Homo sapiens	80-83
26969379-2	2016	PURPOSE: In this study the effects of naturally occurring homochelidonine in comparison to chelidonine on cell cycle progression and cell death in leukemic T-cells with different p53 status are described.	chelidonine	62-73	tumor protein p53	Homo sapiens	179-182
26969379-11	2016	MOLT-4 and Jurkat cells treated with homochelidonine and chelidonine showed features of apoptosis such as phosphatidylserine exposure, a loss of mitochondrial membrane potential and an increase in the caspases -3/7, -8 and -9.	chelidonine	41-52	caspase 3	Homo sapiens	201-225
26969379-12	2016	Western blots indicate that homochelidonine and chelidonine exposure activates Chk1 and Chk2.	chelidonine	32-43	checkpoint kinase 1	Homo sapiens	79-83
26969379-12	2016	Western blots indicate that homochelidonine and chelidonine exposure activates Chk1 and Chk2.	chelidonine	32-43	checkpoint kinase 2	Homo sapiens	88-92
25890994-7	2015	Chelidonine also inhibited COL-I-induced protein kinase B (Akt) activation and translocation to the plasma membrane, however, it did not significantly inhibit the activation of focal adhesion kinase.	chelidonine	0-11	AKT serine/threonine kinase 1	Homo sapiens	59-62
25890994-8	2015	Notably, chelidonine treatment significantly inhibited COL-I-induced formation of the IPP complex and activation of IPP downstream signaling molecules, such as extracellular signal-regulated kinase (ERK)1/2.	chelidonine	9-20	mitogen-activated protein kinase 1	Homo sapiens	160-206
25890994-9	2015	These results suggest that chelidonine exhibits anti-migratory and anti-invasive effects in MDA-MB-231 cells, by suppressing COL-I-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent down-regulation of IPP downstream signaling molecules, such as Akt and ERK1/2.	chelidonine	27-38	AKT serine/threonine kinase 1	Homo sapiens	289-292
25890994-9	2015	These results suggest that chelidonine exhibits anti-migratory and anti-invasive effects in MDA-MB-231 cells, by suppressing COL-I-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent down-regulation of IPP downstream signaling molecules, such as Akt and ERK1/2.	chelidonine	27-38	mitogen-activated protein kinase 3	Homo sapiens	297-303
18325696-5	2008	Chelidonine induced only a slight release of cytochrome c (12h), parallel to caspase-3 activation.	chelidonine	0-11	cytochrome c, somatic	Homo sapiens	45-57
25481375-4	2015	Our data show that hydroalcoholic extracts of greater celandine and its alkaloids, especially berberine, chelidonine and sanguinarine have a significant hERG potassium channel blocking effect.	chelidonine	105-116	ETS transcription factor ERG	Homo sapiens	153-157
22979935-0	2012	Chelidonine isolated from ethanolic extract of Chelidonium majus promotes apoptosis in HeLa cells through p38-p53 and PI3K/AKT signalling pathways.	chelidonine	0-11	mitogen-activated protein kinase 14	Homo sapiens	106-109
22979935-0	2012	Chelidonine isolated from ethanolic extract of Chelidonium majus promotes apoptosis in HeLa cells through p38-p53 and PI3K/AKT signalling pathways.	chelidonine	0-11	tumor protein p53	Homo sapiens	110-113
22979935-0	2012	Chelidonine isolated from ethanolic extract of Chelidonium majus promotes apoptosis in HeLa cells through p38-p53 and PI3K/AKT signalling pathways.	chelidonine	0-11	AKT serine/threonine kinase 1	Homo sapiens	123-126
22979935-10	2012	Studies of signalling pathway revealed that chelidonine could efficiently induce apoptosis through up-regulation of expressions of p38, p53 and other pro-apoptotic genes and down-regulation of expressions of AKT, PI3K, JAK3, STAT3, E6, E7 and other antiapoptotic genes.	chelidonine	44-55	mitogen-activated protein kinase 14	Homo sapiens	131-134
22979935-10	2012	Studies of signalling pathway revealed that chelidonine could efficiently induce apoptosis through up-regulation of expressions of p38, p53 and other pro-apoptotic genes and down-regulation of expressions of AKT, PI3K, JAK3, STAT3, E6, E7 and other antiapoptotic genes.	chelidonine	44-55	tumor protein p53	Homo sapiens	136-139
22979935-10	2012	Studies of signalling pathway revealed that chelidonine could efficiently induce apoptosis through up-regulation of expressions of p38, p53 and other pro-apoptotic genes and down-regulation of expressions of AKT, PI3K, JAK3, STAT3, E6, E7 and other antiapoptotic genes.	chelidonine	44-55	AKT serine/threonine kinase 1	Homo sapiens	208-211
22979935-10	2012	Studies of signalling pathway revealed that chelidonine could efficiently induce apoptosis through up-regulation of expressions of p38, p53 and other pro-apoptotic genes and down-regulation of expressions of AKT, PI3K, JAK3, STAT3, E6, E7 and other antiapoptotic genes.	chelidonine	44-55	Janus kinase 3	Homo sapiens	219-223
22979935-10	2012	Studies of signalling pathway revealed that chelidonine could efficiently induce apoptosis through up-regulation of expressions of p38, p53 and other pro-apoptotic genes and down-regulation of expressions of AKT, PI3K, JAK3, STAT3, E6, E7 and other antiapoptotic genes.	chelidonine	44-55	signal transducer and activator of transcription 3	Homo sapiens	225-230
22979935-11	2012	CONCLUSION: Chelidonine isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways.	chelidonine	12-23	mitogen-activated protein kinase 14	Homo sapiens	131-134
22979935-11	2012	CONCLUSION: Chelidonine isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways.	chelidonine	12-23	tumor protein p53	Homo sapiens	135-138
22979935-11	2012	CONCLUSION: Chelidonine isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways.	chelidonine	12-23	AKT serine/threonine kinase 1	Homo sapiens	143-146
25265580-5	2014	Alteration of expression levels of bax/bcl2, and dapk1a by increasing concentration of chelidonine approves switching the death mode from apoptosis induced by very low to autophagy by high concentrations of this compound.	chelidonine	87-98	BCL2 associated X, apoptosis regulator	Homo sapiens	35-38
25265580-5	2014	Alteration of expression levels of bax/bcl2, and dapk1a by increasing concentration of chelidonine approves switching the death mode from apoptosis induced by very low to autophagy by high concentrations of this compound.	chelidonine	87-98	BCL2 apoptosis regulator	Homo sapiens	39-43
25265580-6	2014	On the other hand, submicromolar concentrations of chelidonine strongly suppressed telomerase at both enzyme activity and hTERT transcriptional level.	chelidonine	51-62	telomerase reverse transcriptase	Homo sapiens	122-127
23238299-2	2013	This study demonstrates that chelidonine and an alkaloid extract from Chelidonium majus, which contains protoberberine and benzo[c]phenanthridine alkaloids, has the ability to overcome MDR of different cancer cell lines through interaction with ABC-transporters, CYP3A4 and GST, by induction of apoptosis, and cytotoxic effects.	chelidonine	29-40	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	263-269
23238299-3	2013	Chelidonine and the alkaloid extract inhibited P-gp/MDR1 activity in a concentration-dependent manner in Caco-2 and CEM/ADR5000 and reversed their doxorubicin resistance.	chelidonine	0-11	phosphoglycolate phosphatase	Homo sapiens	47-51
23238299-3	2013	Chelidonine and the alkaloid extract inhibited P-gp/MDR1 activity in a concentration-dependent manner in Caco-2 and CEM/ADR5000 and reversed their doxorubicin resistance.	chelidonine	0-11	ATP binding cassette subfamily B member 1	Homo sapiens	52-56
23238299-4	2013	In addition, chelidonine and the alkaloid extract inhibited the activity of the drug modifying enzymes CYP3A4 and GST in a dose-dependent manner.	chelidonine	13-24	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	103-109
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	chelidonine	69-80	phosphoglycolate phosphatase	Homo sapiens	149-153
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	chelidonine	69-80	ATP binding cassette subfamily B member 1	Homo sapiens	154-158
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	chelidonine	69-80	MDM4 regulator of p53	Homo sapiens	160-164
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	chelidonine	69-80	BCR pseudogene 1	Homo sapiens	166-170
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	chelidonine	69-80	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	172-178
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	chelidonine	69-80	nuclear receptor subfamily 1 group I member 2	Homo sapiens	189-193
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	chelidonine	69-80	caspase 3	Homo sapiens	227-236
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	chelidonine	69-80	caspase 8	Homo sapiens	241-250
19653337-0	2009	Transcriptional down regulation of hTERT and senescence induction in HepG2 cells by chelidonine.	chelidonine	84-95	telomerase reverse transcriptase	Homo sapiens	35-40
19653337-8	2009	Real-time RT-PCR data showed that the expression of pgp increased three-fold in chelidonine treated HepG2 cells in comparison with the untreated controls.	chelidonine	80-91	ATP binding cassette subfamily B member 1	Homo sapiens	52-55
19653337-10	2009	The relative expression level of Bcl-2 dropped to less than 50% of control cells at a sub-apoptotic concentration of chelidonine and subsequently increased to higher than 120% at LD(50).	chelidonine	117-128	BCL2 apoptosis regulator	Homo sapiens	33-38
19653337-12	2009	Real-time RT-PCR experiments indicated a drastic decrease in expression level of hTERT subunit of telomerase under treatment with chelidonine.	chelidonine	130-141	telomerase reverse transcriptase	Homo sapiens	81-86
19653337-14	2009	CONCLUSION: Chelidonine reduces telomerase activity through down-regulation of hTERT expression.	chelidonine	12-23	telomerase reverse transcriptase	Homo sapiens	79-84
18325696-5	2008	Chelidonine induced only a slight release of cytochrome c (12h), parallel to caspase-3 activation.	chelidonine	0-11	caspase 3	Homo sapiens	77-86
34884773-0	2021	Opposing Effects of Chelidonine on Tyrosine and Serine Phosphorylation of STAT3 in Human Uveal Melanoma Cells.	chelidonine	20-31	signal transducer and activator of transcription 3	Homo sapiens	74-79
11211931-7	2001	Exposure of all cell lines examined to chelidonine leads to activation of the stress-activated protein kinase/jun kinase pathway (SAPK/JNK).	chelidonine	39-50	mitogen-activated protein kinase 9	Homo sapiens	130-134
11211931-7	2001	Exposure of all cell lines examined to chelidonine leads to activation of the stress-activated protein kinase/jun kinase pathway (SAPK/JNK).	chelidonine	39-50	mitogen-activated protein kinase 9	Homo sapiens	135-138
34884773-7	2021	According to our flow cytometry and confocal microscopy data, chelidonine abrogated IL-6-induced activation and nuclear translocation, but amplified constitutive serine phosphorylation of STAT3.	chelidonine	62-73	interleukin 6	Homo sapiens	84-88
34884773-7	2021	According to our flow cytometry and confocal microscopy data, chelidonine abrogated IL-6-induced activation and nuclear translocation, but amplified constitutive serine phosphorylation of STAT3.	chelidonine	62-73	signal transducer and activator of transcription 3	Homo sapiens	188-193