PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33592143-3	2021	Surface plasmon resonance experiments showed that the highly sulfated HS tetrasaccharides bearing full 2-O, 6-O, and N-sulfations exhibited the strongest binding with Abeta among the tetrasaccharides investigated.	tetrasaccharides	73-89	amyloid beta precursor protein	Homo sapiens	167-172
1123348-14	1975	Tetrasaccharides from nonsulfated products contained L-iduronic acid indicating that C-5 inversion at solitary sites can occur in the absence of sulfation of adjacent hexosamine moieties.	tetrasaccharides	0-16	complement C5	Homo sapiens	85-88
33495350-5	2021	Further work identified a specific N-terminal glycopeptide region of CD43 containing clusters of disialylated O-glycan tetrasaccharides that form specific Siglec-7 binding motifs.	tetrasaccharides	119-135	sialophorin	Homo sapiens	69-73
33495350-5	2021	Further work identified a specific N-terminal glycopeptide region of CD43 containing clusters of disialylated O-glycan tetrasaccharides that form specific Siglec-7 binding motifs.	tetrasaccharides	119-135	sialic acid binding Ig like lectin 7	Homo sapiens	155-163
28389983-8	2017	The present work comprehensively investigates the efficacy of these ions for assigning the C-5 stereochemistry of the reducing end uronic acid in 33 HS tetrasaccharides.	tetrasaccharides	152-168	complement C5	Homo sapiens	91-94
29031112-4	2017	After exhaustively digesting LMWHs with the mixture of heparinase I, II and III, almost all the resulting oligosaccharide building blocks, including the three 3-O-sulfated tetrasaccharides derived from the ATIII-binding site, were resolved by CE separation.	tetrasaccharides	172-188	serpin family C member 1	Homo sapiens	206-211
29070611-7	2017	Starting with four sets of 254 HS tetrasaccharides, we identified 25 sequences that bind to CXCL13 monomer, among which a single one bound to CXCL13 dimer with high consistency.	tetrasaccharides	34-50	C-X-C motif chemokine ligand 13	Homo sapiens	92-98
29070611-7	2017	Starting with four sets of 254 HS tetrasaccharides, we identified 25 sequences that bind to CXCL13 monomer, among which a single one bound to CXCL13 dimer with high consistency.	tetrasaccharides	34-50	C-X-C motif chemokine ligand 13	Homo sapiens	142-148
28952509-12	2017	Our findings show the positive impact of 6-biotinylation of tetrasaccharides on galectin-3 binding, which broadens the recent design approaches for producing high-affinity ligands.	tetrasaccharides	60-76	galectin 3	Homo sapiens	80-90
22587667-0	2012	Adsorption of chain type-specific ABO antibodies on Sepharose-linked A and B tetrasaccharides.	tetrasaccharides	77-93	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	34-37
23494731-4	2013	Collected tetrasaccharides were analyzed by fully automated (NanoMate robot) chip-based nanoESI high capacity ion trap multistage MS (MS(2) -MS(4) ) recently introduced in glycosaminoglycan research by our laboratory.	tetrasaccharides	10-26	minisatellites detected by probe MMS4	Mus musculus	140-146
25395406-5	2015	The intrinsic affinities of the HBGA oligosaccharides for the P particle range from 500 to 2300 M(-1), while those of the A and B trisaccharides and the A and B type 6 tetrasaccharides for the VLP range from 1000 to 4000 M(-1).	tetrasaccharides	168-184	hemoglobin subunit gamma 1	Homo sapiens	32-36
8872118-4	1996	All of the seven tetrasaccharides shared the common core structure GlcA beta 1-3GalNAc beta 1-4GLcA beta 1-3GalNAc with various sulfation profiles.	tetrasaccharides	17-33	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	72-78
22305408-0	2012	Block synthesis of A tetrasaccharides (types 1, 3, and 4) related to the human ABO blood group system.	tetrasaccharides	21-37	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	79-94
21913222-6	2012	HAS2 mRNA expression was altered after the treatment with both tetrasaccharides and decasaccharides.	tetrasaccharides	63-79	hyaluronan synthase 2	Homo sapiens	0-4
21981750-5	2012	In contrast, ABO alloantibodies required a minimum trisaccharide Gal(NAc)alpha1-3(Fucalpha1-2)Gal epitope and recognize the elongated type-specific tetrasaccharides.	tetrasaccharides	148-164	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	13-16
20099847-3	2010	Moreover, these heteropolymeric structures allow units as short as tetrasaccharides to self-assemble through carbohydrate-carbohydrate interactions that are induced by the presence of Ca(II), a known dynamic trigger in planta.	tetrasaccharides	67-83	carbonic anhydrase 2	Homo sapiens	184-190
20641286-12	2004	(5) have developed liposomes containing SLX tetrasaccharides and Cy5.5-conjugated human serum albumin (SLX-Lipo-Cy5.5) for noninvasive magnetic resonance imaging of E-selectin expression in inflammation and tumor tissue.	tetrasaccharides	44-60	selectin E	Homo sapiens	165-175
15703907-2	2005	The beta-galactosidase activity of whole bifidobacterial cells showed an optimum activity at pH 6.8-7.0 and 40 degrees C. The transgalactosylation activity of the B. bifidum cells from 50% (w/w) lactose resulted in a galactooligosaccharide mixture (20% w/w) comprising (w/w): 25% disaccharides, 35% trisaccharides, 25% tetrasaccharides and 15% pentasaccharides.	tetrasaccharides	319-335	galactosidase beta 1	Homo sapiens	4-22
15526371-11	2004	The most effective inhibitors of IL-4 and IL-5 secretion are tetrasaccharides and hexasaccharides, respectively.	tetrasaccharides	61-77	interleukin 4	Homo sapiens	33-37
15526371-11	2004	The most effective inhibitors of IL-4 and IL-5 secretion are tetrasaccharides and hexasaccharides, respectively.	tetrasaccharides	61-77	interleukin 5	Homo sapiens	42-46
11864979-6	2002	Treatment of the cells with tetrasaccharides of HA up-regulated not only expression of the Hsp72 protein but also Hsp72 mRNA expression and enhanced activation of HSF1, a transcription factor controlling Hsp72 expression, after exposure to hyperthermia.	tetrasaccharides	28-44	heat shock protein family A (Hsp70) member 1A	Homo sapiens	91-96
11864979-6	2002	Treatment of the cells with tetrasaccharides of HA up-regulated not only expression of the Hsp72 protein but also Hsp72 mRNA expression and enhanced activation of HSF1, a transcription factor controlling Hsp72 expression, after exposure to hyperthermia.	tetrasaccharides	28-44	heat shock protein family A (Hsp70) member 1A	Homo sapiens	114-119
11864979-6	2002	Treatment of the cells with tetrasaccharides of HA up-regulated not only expression of the Hsp72 protein but also Hsp72 mRNA expression and enhanced activation of HSF1, a transcription factor controlling Hsp72 expression, after exposure to hyperthermia.	tetrasaccharides	28-44	heat shock transcription factor 1	Homo sapiens	163-167
11864979-6	2002	Treatment of the cells with tetrasaccharides of HA up-regulated not only expression of the Hsp72 protein but also Hsp72 mRNA expression and enhanced activation of HSF1, a transcription factor controlling Hsp72 expression, after exposure to hyperthermia.	tetrasaccharides	28-44	heat shock protein family A (Hsp70) member 1A	Homo sapiens	114-119
11864979-9	2002	These results suggest that a certain size of oligosaccharides, i.e. the tetrasaccharides of HA, up-regulates Hsp72 expression by enhancing the activation of HSF1 under stress conditions and suppresses cell death.	tetrasaccharides	72-88	heat shock protein family A (Hsp70) member 1A	Homo sapiens	109-114
11864979-9	2002	These results suggest that a certain size of oligosaccharides, i.e. the tetrasaccharides of HA, up-regulates Hsp72 expression by enhancing the activation of HSF1 under stress conditions and suppresses cell death.	tetrasaccharides	72-88	heat shock transcription factor 1	Homo sapiens	157-161
15324304-4	2004	When [35S]glycosaminoglycans formed from DSDS after incubation with [35S]PAPS and C4ST-1 were digested with chondroitinase ACII, a major part of the radioactivity was recovered in disaccharide fractions and the remainder distributed to tetrasaccharides and larger fractions, indicating that C4ST-1 mainly transferred sulphate to position 4 of the GalNAc residue located at the GlcA-GalNAc-GlcA sequence.	tetrasaccharides	236-252	carbohydrate sulfotransferase 11	Rattus norvegicus	82-88
12000311-2	2002	First, using an optical biosensor, we show that FGF-2 did not bind disaccharides, but definitively bound to tetrasaccharides.	tetrasaccharides	108-124	fibroblast growth factor 2	Rattus norvegicus	48-53
12000311-6	2002	In the same cells FGF-2 in the presence of tetrasaccharides and longer oligosaccharides was able to restore DNA synthesis and enable the sustained dual phosphorylation of p42/44(MAPK).	tetrasaccharides	43-59	fibroblast growth factor 2	Rattus norvegicus	18-23
12000311-9	2002	These results demonstrate that tetrasaccharides are able to bind FGF-2 and enable FGF-2 to stimulate cell proliferation, which sets important boundary conditions for models of the FGF-2-heparan sulphate-FGF receptor complex.	tetrasaccharides	31-47	fibroblast growth factor 2	Rattus norvegicus	65-70
12000311-9	2002	These results demonstrate that tetrasaccharides are able to bind FGF-2 and enable FGF-2 to stimulate cell proliferation, which sets important boundary conditions for models of the FGF-2-heparan sulphate-FGF receptor complex.	tetrasaccharides	31-47	fibroblast growth factor 2	Rattus norvegicus	82-87
12000311-9	2002	These results demonstrate that tetrasaccharides are able to bind FGF-2 and enable FGF-2 to stimulate cell proliferation, which sets important boundary conditions for models of the FGF-2-heparan sulphate-FGF receptor complex.	tetrasaccharides	31-47	fibroblast growth factor 2	Rattus norvegicus	82-87
11799124-2	2002	In optical biosensor binding assays, competition by oligosaccharides for binding of HGF/SF to immobilized heparin showed that disaccharides failed to compete, whereas tetrasaccharides inhibited HGF/SF binding (IC(50) 8 microg/ml).	tetrasaccharides	167-183	hepatocyte growth factor	Homo sapiens	194-200
10026155-0	1999	Novel proteoglycan linkage tetrasaccharides of human urinary soluble thrombomodulin, SO4-3GlcAbeta1-3Galbeta1-3(+/-Siaalpha2-6)Galbeta1-4Xyl.	tetrasaccharides	27-43	thrombomodulin	Homo sapiens	69-83
8872118-4	1996	All of the seven tetrasaccharides shared the common core structure GlcA beta 1-3GalNAc beta 1-4GLcA beta 1-3GalNAc with various sulfation profiles.	tetrasaccharides	17-33	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	87-93
8536692-9	1995	The proportion of [35S]oligosaccharides with greater than six monosaccharides decreases on account of disaccharides and tetrasaccharides under the influence of bFGF.	tetrasaccharides	120-136	fibroblast growth factor 2	Homo sapiens	160-164
7694675-11	1993	We conclude that heparin oligosaccharides, including non-anticoagulant tetrasaccharides, are effective L- and P-selectin inhibitors in vitro and have anti-inflammatory activity in vivo.	tetrasaccharides	71-87	selectin, platelet	Mus musculus	110-120
7827415-2	1994	The tetrasaccharides share the common core structure delta 4,5HexA alpha 1-4GlcN alpha 1-4HexA1-4GlcN (where delta 4,5HexA is 4-deoxy-alpha-L-threo-hex-4-enopyranosyluronic acid and HexA is hexuronic acid), with zero, one or two sulphate groups.	tetrasaccharides	4-20	beta-hexosaminidase subunit alpha	Bos taurus	62-66
1633607-0	1992	Spacer-modified, photolabile tetrasaccharides as analogues of maltopentaose are versatile probes for porcine pancreatic alpha-amylase.	tetrasaccharides	29-45	amylase alpha 2A	Homo sapiens	109-133
8143288-0	1993	Use of human-milk fucosyltransferase in the chemoenzymic synthesis of analogues of the sialyl Lewis(a) and sialyl Lewis(x) tetrasaccharides modified at the C-2 position of the reducing unit.	tetrasaccharides	123-139	complement C2	Homo sapiens	156-159
1826222-4	1991	T-lymphoid cells from patients with chronic T-lymphocytic leukemia, on the other hand, mainly express the tetrasaccharides NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----6)GalNAc on leukosialin, but they also express a small significant amount of the hexasaccharides.	tetrasaccharides	106-122	LOC105369247	Homo sapiens	188-199
2249697-0	1990	Structural characterization of sialylated tetrasaccharides and pentasaccharides with blood group H and Le(x) activity isolated from bovine submaxillary mucin.	tetrasaccharides	42-58	mucin 1, cell surface associated	Bos taurus	152-157
34213045-0	2021	Midkine Interaction with Chondroitin Sulfate Model Synthetic Tetrasaccharides and Their Mimetics: The Role of Aromatic Interactions.	tetrasaccharides	61-77	midkine	Mus musculus	0-7
4035368-3	1985	A pentasaccharide analogue lacking this 3-0-sulfate group and two different tetrasaccharides, each being part of the pentasaccharide sequence with AT III affinity, have also been synthesized.	tetrasaccharides	76-92	serpin family C member 1	Homo sapiens	147-153
3239749-4	1988	Specifically, sialylated tetrasaccharides containing the Gal beta(1,3)GlcNAc sequence were retained much more than their Gal beta(1,4)GlcNAc- or Gal-beta(1,4)GalNAc-sialylated counterparts.	tetrasaccharides	25-41	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	61-69