PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33246826-0	2021	Physcion 8-O-beta-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-kappaB P65 nuclear expression.	physcion 8-O-glucopyranoside	0-33	sirtuin 3	Rattus norvegicus	107-112
33246826-1	2021	Physcion 8-O-beta-glucopyranoside (PSG), an anthraquinone extracted from Rumex japonicus Houtt, has various pharmacological effects, however, the effect of PSG on liver fibrosis and its related mechanism remain to be determined.	physcion 8-O-glucopyranoside	0-33	pregnancy-specific beta 1-glycoprotein	Rattus norvegicus	35-38
33246826-1	2021	Physcion 8-O-beta-glucopyranoside (PSG), an anthraquinone extracted from Rumex japonicus Houtt, has various pharmacological effects, however, the effect of PSG on liver fibrosis and its related mechanism remain to be determined.	physcion 8-O-glucopyranoside	0-33	pregnancy-specific beta 1-glycoprotein	Rattus norvegicus	156-159
31274843-10	2019	Finally, activation of AMPK/SIRT1 signaling was upstream of PG-induced autophagy.	physcion 8-O-glucopyranoside	60-62	sirtuin 1	Homo sapiens	28-33
32635979-1	2020	This study aimed to investigate whether physcion 8-O-beta-glucopyranoside (PG) exerted anti-tumor effects in endometrial cancer cells via regulating the long non-coding RNA lnc-SLC4A1-1.	physcion 8-O-glucopyranoside	75-77	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	177-183
32635979-3	2020	Subsequently, the role and regulatory mechanism of lnc-SLC4A1-1 dysregulation in PG-treated endometrial cancer cells were explored.	physcion 8-O-glucopyranoside	81-83	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	55-61
32635979-5	2020	Moreover, PG decreased the level of lnc-SLC4A1-1, and high levels of lnc-SLC4A1-1 reversed the effects of PG on Ishikawa cells.	physcion 8-O-glucopyranoside	10-12	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	40-46
32635979-5	2020	Moreover, PG decreased the level of lnc-SLC4A1-1, and high levels of lnc-SLC4A1-1 reversed the effects of PG on Ishikawa cells.	physcion 8-O-glucopyranoside	106-108	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	73-79
32635979-7	2020	PG treatment depressed the NF-kappaB signal in Ishikawa cells, which were significantly reversed after overexpression of lnc-SLC4A1-1.	physcion 8-O-glucopyranoside	0-2	nuclear factor kappa B subunit 1	Homo sapiens	27-36
32635979-7	2020	PG treatment depressed the NF-kappaB signal in Ishikawa cells, which were significantly reversed after overexpression of lnc-SLC4A1-1.	physcion 8-O-glucopyranoside	0-2	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	125-131
32635979-9	2020	Lnc-SLC4A1-1/H3K27ac/NF-kappaB pathway may be a possible mechanism to mediate the anti-tumor effects of PG, which provide a promising targeted strategy for treatment of endometrial cancer.	physcion 8-O-glucopyranoside	104-106	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	4-10
32635979-9	2020	Lnc-SLC4A1-1/H3K27ac/NF-kappaB pathway may be a possible mechanism to mediate the anti-tumor effects of PG, which provide a promising targeted strategy for treatment of endometrial cancer.	physcion 8-O-glucopyranoside	104-106	nuclear factor kappa B subunit 1	Homo sapiens	21-30
31299866-11	2019	Our findings reveal that NORAD/miR-608/STAT3 axis is pivotal in mediating the antineoplastic impacts of PG on ovarian cancer cells, which may offer a novel explanation in the therapy of ovarian cancer.	physcion 8-O-glucopyranoside	104-106	microRNA 608	Homo sapiens	31-38
31299866-9	2019	Overexpression of NORAD reversed the effects of PG treatment on the cell biological performances of SKOV3 cells, which were further reversed after overexpression of miR-608 simultaneously.	physcion 8-O-glucopyranoside	48-50	microRNA 608	Homo sapiens	165-172
31299866-10	2019	Furthermore, STAT3 was tested as a target gene of miR-608, and the impact of NORAD in PG-treated SKOV3 cells were through the miR-608-mediated STAT3.	physcion 8-O-glucopyranoside	86-88	signal transducer and activator of transcription 3	Homo sapiens	13-18
31299866-10	2019	Furthermore, STAT3 was tested as a target gene of miR-608, and the impact of NORAD in PG-treated SKOV3 cells were through the miR-608-mediated STAT3.	physcion 8-O-glucopyranoside	86-88	microRNA 608	Homo sapiens	50-57
31299866-10	2019	Furthermore, STAT3 was tested as a target gene of miR-608, and the impact of NORAD in PG-treated SKOV3 cells were through the miR-608-mediated STAT3.	physcion 8-O-glucopyranoside	86-88	microRNA 608	Homo sapiens	126-133
31299866-10	2019	Furthermore, STAT3 was tested as a target gene of miR-608, and the impact of NORAD in PG-treated SKOV3 cells were through the miR-608-mediated STAT3.	physcion 8-O-glucopyranoside	86-88	signal transducer and activator of transcription 3	Homo sapiens	143-148
31299866-11	2019	Our findings reveal that NORAD/miR-608/STAT3 axis is pivotal in mediating the antineoplastic impacts of PG on ovarian cancer cells, which may offer a novel explanation in the therapy of ovarian cancer.	physcion 8-O-glucopyranoside	104-106	signal transducer and activator of transcription 3	Homo sapiens	39-44
31274843-11	2019	CONCLUSIONS: PG has potential pharmacological effects against oxidative damage-induced HUVEC injury through inducing AMPK/SIRT1-mediated autophagy.	physcion 8-O-glucopyranoside	13-15	sirtuin 1	Homo sapiens	122-127
31298363-15	2019	The pro-apoptotic activity of PG was confirmed by flow cytometry, activation of caspase-3 and PARP, upregulation of Bax and downregulation of Bcl-2.	physcion 8-O-glucopyranoside	30-32	caspase 3	Homo sapiens	80-89
31298363-15	2019	The pro-apoptotic activity of PG was confirmed by flow cytometry, activation of caspase-3 and PARP, upregulation of Bax and downregulation of Bcl-2.	physcion 8-O-glucopyranoside	30-32	collagen type XI alpha 2 chain	Homo sapiens	94-98
31298363-15	2019	The pro-apoptotic activity of PG was confirmed by flow cytometry, activation of caspase-3 and PARP, upregulation of Bax and downregulation of Bcl-2.	physcion 8-O-glucopyranoside	30-32	BCL2 associated X, apoptosis regulator	Homo sapiens	116-119
31298363-15	2019	The pro-apoptotic activity of PG was confirmed by flow cytometry, activation of caspase-3 and PARP, upregulation of Bax and downregulation of Bcl-2.	physcion 8-O-glucopyranoside	30-32	BCL2 apoptosis regulator	Homo sapiens	142-147
31298363-16	2019	The ability of PG to inhibit migration and invasion was evidenced by a decrease in wound healing and invasive cell number, as well as downregulation of MMP-2 and upregulation of TIMP-3.	physcion 8-O-glucopyranoside	15-17	matrix metallopeptidase 2	Homo sapiens	152-157
31298363-16	2019	The ability of PG to inhibit migration and invasion was evidenced by a decrease in wound healing and invasive cell number, as well as downregulation of MMP-2 and upregulation of TIMP-3.	physcion 8-O-glucopyranoside	15-17	TIMP metallopeptidase inhibitor 3	Homo sapiens	178-184
31298363-17	2019	Microarray and qRT-PCR showed that miR-25 expression was downregulated by PG treatment.	physcion 8-O-glucopyranoside	74-76	microRNA 25	Homo sapiens	35-41
31298363-18	2019	Moreover, our results indicated that the anti-cancer activities of PG were augmented by miR-25 knockdown and attenuated by ectopic miR-25 expression.	physcion 8-O-glucopyranoside	67-69	microRNA 25	Homo sapiens	88-94
31298363-18	2019	Moreover, our results indicated that the anti-cancer activities of PG were augmented by miR-25 knockdown and attenuated by ectopic miR-25 expression.	physcion 8-O-glucopyranoside	67-69	microRNA 25	Homo sapiens	131-137
27416558-7	2016	RESULTS: Our results provide experimental evidence that PG inhibits growth and suppresses invasion of HCC cells by downregulating DNMT1 via ROS-dependent AMP-activated protein kinase (AMPK)-mediated modulation of transcription factor Sp1.	physcion 8-O-glucopyranoside	56-58	DNA methyltransferase 1	Homo sapiens	130-135
30092415-10	2018	Mechanistically, the anti-leukemia activity of PG was mediated by its ability to repress SphK1 and thus modulate ceramide-S1P rheostat.	physcion 8-O-glucopyranoside	47-49	sphingosine kinase 1	Homo sapiens	89-94
27429847-4	2016	Our results showed that PG exerted anti-proliferative effects and induced apoptosis in MG-63 cells via the intrinsic mitochondrial pathway, accompanied by loss of mitochondrial membrane potential (MMP) and cytochrome C release from the mitochondria.	physcion 8-O-glucopyranoside	24-26	cytochrome c, somatic	Homo sapiens	206-218
27429847-5	2016	In addition, physcion treatment significantly inhibited extracellular matrix metalloproteinase inducer (EMMPRIN) expression in MG-63 cells, in a dose-dependent manner; meanwhile, EMMPRIN protein overexpression markedly reduced PG-induced apoptosis.	physcion 8-O-glucopyranoside	227-229	basigin (Ok blood group)	Homo sapiens	179-186
27429847-6	2016	Moreover, our findings suggested that the modulatory effects of PG on EMMPRIN were due, at least in part, to regulation of an ROS-miR-27a/ZBTB10-Sp1 transcription factor pathway.	physcion 8-O-glucopyranoside	64-66	basigin (Ok blood group)	Homo sapiens	70-77
27429847-6	2016	Moreover, our findings suggested that the modulatory effects of PG on EMMPRIN were due, at least in part, to regulation of an ROS-miR-27a/ZBTB10-Sp1 transcription factor pathway.	physcion 8-O-glucopyranoside	64-66	microRNA 27a	Homo sapiens	130-137
27429847-6	2016	Moreover, our findings suggested that the modulatory effects of PG on EMMPRIN were due, at least in part, to regulation of an ROS-miR-27a/ZBTB10-Sp1 transcription factor pathway.	physcion 8-O-glucopyranoside	64-66	zinc finger and BTB domain containing 10	Homo sapiens	138-144
27063218-8	2016	PG-induced apoptosis was mediated via the intrinsic mitochondrial pathway, as evidenced by the decreased Bcl-2, increased Bax and Bax/Bcl-2 ratio, as well as the loss of MMP, caspase-9 activation, and increased cytosolic cytochrome c.	physcion 8-O-glucopyranoside	0-2	BCL2 apoptosis regulator	Homo sapiens	105-110
27063218-8	2016	PG-induced apoptosis was mediated via the intrinsic mitochondrial pathway, as evidenced by the decreased Bcl-2, increased Bax and Bax/Bcl-2 ratio, as well as the loss of MMP, caspase-9 activation, and increased cytosolic cytochrome c.	physcion 8-O-glucopyranoside	0-2	BCL2 associated X, apoptosis regulator	Homo sapiens	122-125
27063218-8	2016	PG-induced apoptosis was mediated via the intrinsic mitochondrial pathway, as evidenced by the decreased Bcl-2, increased Bax and Bax/Bcl-2 ratio, as well as the loss of MMP, caspase-9 activation, and increased cytosolic cytochrome c.	physcion 8-O-glucopyranoside	0-2	BCL2 associated X, apoptosis regulator	Homo sapiens	130-133
27063218-8	2016	PG-induced apoptosis was mediated via the intrinsic mitochondrial pathway, as evidenced by the decreased Bcl-2, increased Bax and Bax/Bcl-2 ratio, as well as the loss of MMP, caspase-9 activation, and increased cytosolic cytochrome c.	physcion 8-O-glucopyranoside	0-2	BCL2 apoptosis regulator	Homo sapiens	134-139
27063218-8	2016	PG-induced apoptosis was mediated via the intrinsic mitochondrial pathway, as evidenced by the decreased Bcl-2, increased Bax and Bax/Bcl-2 ratio, as well as the loss of MMP, caspase-9 activation, and increased cytosolic cytochrome c.	physcion 8-O-glucopyranoside	0-2	caspase 9	Homo sapiens	175-184
27063218-8	2016	PG-induced apoptosis was mediated via the intrinsic mitochondrial pathway, as evidenced by the decreased Bcl-2, increased Bax and Bax/Bcl-2 ratio, as well as the loss of MMP, caspase-9 activation, and increased cytosolic cytochrome c.	physcion 8-O-glucopyranoside	0-2	cytochrome c, somatic	Homo sapiens	221-233
27063218-10	2016	Meanwhile PG increased the expression of tumor suppressor PTEN, and decreased p-Akt, p-GSK3beta and miR-21 levels.	physcion 8-O-glucopyranoside	10-12	phosphatase and tensin homolog	Homo sapiens	58-62
27063218-10	2016	Meanwhile PG increased the expression of tumor suppressor PTEN, and decreased p-Akt, p-GSK3beta and miR-21 levels.	physcion 8-O-glucopyranoside	10-12	AKT serine/threonine kinase 1	Homo sapiens	80-83
27063218-10	2016	Meanwhile PG increased the expression of tumor suppressor PTEN, and decreased p-Akt, p-GSK3beta and miR-21 levels.	physcion 8-O-glucopyranoside	10-12	glycogen synthase kinase 3 beta	Homo sapiens	87-95
27063218-10	2016	Meanwhile PG increased the expression of tumor suppressor PTEN, and decreased p-Akt, p-GSK3beta and miR-21 levels.	physcion 8-O-glucopyranoside	10-12	microRNA 21	Homo sapiens	100-106
27063218-11	2016	Pharmacological activation of Akt/GSK3beta signaling or transfection with miR-21 mimic abolished PG-induced survivin reduction and cell apoptosis.	physcion 8-O-glucopyranoside	97-99	AKT serine/threonine kinase 1	Homo sapiens	30-33
27063218-11	2016	Pharmacological activation of Akt/GSK3beta signaling or transfection with miR-21 mimic abolished PG-induced survivin reduction and cell apoptosis.	physcion 8-O-glucopyranoside	97-99	glycogen synthase kinase 3 beta	Homo sapiens	34-42
27063218-11	2016	Pharmacological activation of Akt/GSK3beta signaling or transfection with miR-21 mimic abolished PG-induced survivin reduction and cell apoptosis.	physcion 8-O-glucopyranoside	97-99	microRNA 21	Homo sapiens	74-80