PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
22240917-3	2012	To elucidate the contribution of partial agonistic activity of SM-368229 for MR in the mitigation of serum potassium elevation, we studied the relationships between sodium balance decrease, as an index of antimineralocorticoid action, and serum potassium elevation in adrenalectomized and/or potassium-loaded rats, using SM-368229 and its derivatives (DSR-11861 and DSR-14397) showing different partial agonist activities for MR (12%, 0%, and 36%, respectively).	Samarium	63-65	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	77-79
22036725-9	2012	SB203580, an inhibitor of p38 MAPK, inhibited SM-induced priming.	Samarium	46-48	mitogen-activated protein kinase 14	Homo sapiens	26-29
22302095-5	2012	In both experiments, SM-368229 prevented the increase in systolic blood pressure, heart/kidney weights, and urinary protein/N-acetyl-beta-D- glucosaminidase excretion caused by aldosterone infusion.	Samarium	21-23	O-GlcNAcase	Rattus norvegicus	124-156
22343086-8	2012	Additionally, injection of STC-1 into Sm potentiated the AP responses to electrical stimulation of the ipsilateral aortic depressor nerve.	Samarium	38-40	stanniocalcin 1	Rattus norvegicus	27-32
22036725-11	2012	In addition, SM enhanced phosphorylation of NF-kB p65 and release of TNF-alpha, interleukin (IL)-6 and IL-8.	Samarium	13-15	tumor necrosis factor	Homo sapiens	69-78
22036725-11	2012	In addition, SM enhanced phosphorylation of NF-kB p65 and release of TNF-alpha, interleukin (IL)-6 and IL-8.	Samarium	13-15	interleukin 6	Homo sapiens	80-98
22036725-11	2012	In addition, SM enhanced phosphorylation of NF-kB p65 and release of TNF-alpha, interleukin (IL)-6 and IL-8.	Samarium	13-15	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
20637275-10	2011	IFN-gamma was increased in both of the peel extract-treated groups, while TNF-alpha, which had been decreased by tumor growth, was rescued to the normal level in SM content and peel extracts-treated groups.	Samarium	162-164	tumor necrosis factor	Mus musculus	74-83
21844222-8	2011	Sms2 deficiency increased cell membrane ceramide but decreased SM levels.	Samarium	63-65	sphingomyelin synthase 2	Mus musculus	0-4
21844222-10	2011	We have concluded that Sptlc2 heterozygous deficiency- or Sms2 deficiency-mediated reduction of SM in the plasma membranes leads to an improvement in tissue and whole-body insulin sensitivity.	Samarium	96-98	serine palmitoyltransferase, long chain base subunit 2	Mus musculus	23-29
21781310-1	2011	BACKGROUND: While there is growing evidence for the efficacy of SM to treat LBP, little is known on the mechanisms and physiologic effects of these treatments.	Samarium	64-66	lipopolysaccharide binding protein	Homo sapiens	76-79
21454546-5	2011	The vasodilator PGI(2) analog, cicaprost, increased Rap1 activity and decreased RhoA activity in intact SMs.	Samarium	104-107	ras homolog family member A	Rattus norvegicus	80-84
20826800-3	2010	When expressed in human embryonic kidney cells stably expressing Ca(v)2.3, beta(Sm) accelerates Ca(2+)/calmodulin-independent inactivation of Ca(v)2.3.	Samarium	79-83	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	65-73
20826800-3	2010	When expressed in human embryonic kidney cells stably expressing Ca(v)2.3, beta(Sm) accelerates Ca(2+)/calmodulin-independent inactivation of Ca(v)2.3.	Samarium	79-83	calmodulin 1	Homo sapiens	103-113
20826800-3	2010	When expressed in human embryonic kidney cells stably expressing Ca(v)2.3, beta(Sm) accelerates Ca(2+)/calmodulin-independent inactivation of Ca(v)2.3.	Samarium	79-83	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	142-150
20218689-0	2010	Heterobimetallic transition metal/rare earth metal bifunctional catalysis: a Cu/Sm/Schiff base complex for syn-selective catalytic asymmetric nitro-Mannich reaction.	Samarium	80-82	synemin	Homo sapiens	107-110
20619539-1	2010	Samarium and nitrogen co-doped titania (Sm/N-TiO(2)) was successfully prepared via coprecipitation method.	Samarium	0-8	small nuclear ribonucleoprotein polypeptide N	Homo sapiens	40-44
20036255-1	2010	The cytosolic protein CERT transfers ceramide from the endoplasmic reticulum to the Golgi apparatus where ceramide is converted to SM.	Samarium	131-133	ceramide transporter 1	Homo sapiens	22-26
18846295-2	2008	We summarize, by the same token, a series of conditions and characteristics that are common to most SM-SERS conditions, and discuss their implications for the understanding of data and for the comparison among different methods.	Samarium	100-102	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	103-107
19071056-0	2009	Optical properties and spectroscope parameters of Sm(DBM)(3)Phen-doped poly(methyl methacrylate).	Samarium	50-52	CLLS2	Homo sapiens	53-56
18203710-9	2008	In the Cox proportional hazards model, preoperative PSA of >/=20 ng/ml and a pathological T stage of pT3a/pT3b were significant risk factors for biochemical recurrence in patients with positive SMs.	Samarium	197-200	kallikrein related peptidase 3	Homo sapiens	52-55
18399223-1	2008	The reaction of Sm{N(SiMe3)2}3 with the bis(phenol)amines H2O2N(R) (H2O2N(R) = RCH2CH2N(2-HO-3,5-C6H2(t)Bu2)2; R = OMe, NMe2 or Me) gave exclusively zwitterions Sm(O2N(R))(HO2N(R)).	Samarium	16-18	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	120-124
17616479-10	2007	We measured cellular lipid levels, including SM, ceramide, phosphatidylcholine, and diacylglycerol and found that SMS1 and SMS2 siRNA treatment caused a significant decrease of SM levels (20% and 11%, respectively), compared to control siRNA treatment; SMS1 but not SMS2 siRNA treatment caused a significant increase of ceramide levels (10%).	Samarium	45-47	sphingomyelin synthase 1	Homo sapiens	114-118
17674800-1	2007	OBJECTIVE: To investigate the effect of SM on aquaporin-1 (AQP1) expression in rats with acute lung injury (ALI), and study protection against ALI.	Samarium	40-42	aquaporin 1	Rattus norvegicus	59-63
16508943-11	2006	CONCLUSION: PDGF-C and PDGF-D are expressed by synovial fibroblasts and macrophages in RA and OA SMs.	Samarium	97-100	platelet derived growth factor C	Homo sapiens	12-18
16540379-3	2006	In this study, we investigated the inhibitory effect of SM on TNF-alpha induced human aortic smooth muscle cells (HASMC) migration and MMP-9 activity.	Samarium	56-58	tumor necrosis factor	Homo sapiens	62-71
16540379-11	2006	The Matrigel migration assay showed that SM effectively inhibited the TNF-alpha induced migration of HASMC as compared with the control group in a dose-dependent manner (IC50 = 65 microg/ml) and that the EtOAc fraction effectively inhibited the migration of HASMC, as compared with the control group in a dose-dependent manner.	Samarium	41-43	tumor necrosis factor	Homo sapiens	70-79
16540379-12	2006	These results suggest that SM could be used as potential anti-atherosclerotic agent for anti-migration in TNF-alpha treated HASMC.	Samarium	27-29	tumor necrosis factor	Homo sapiens	106-115
16508943-11	2006	CONCLUSION: PDGF-C and PDGF-D are expressed by synovial fibroblasts and macrophages in RA and OA SMs.	Samarium	97-100	platelet derived growth factor D	Homo sapiens	23-29
15388249-3	2004	The vanilloid olvanil reduces SM-induced edema and mRNA expression of cytokines and chemokines, suggesting that blocking the inflammatory effects of neuropeptides, such as substance P (SP), may provide protection against SM-induced dermal injury.	Samarium	30-32	tachykinin 1	Mus musculus	172-183
15651846-10	2005	Several genes that are significantly upregulated in a dose-dependent fashion have been reported as p53 responsive genes, suggesting that cell cycle regulation and p53 activation are involved in the response to SM exposure in the lung.	Samarium	210-212	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	99-102
15651846-10	2005	Several genes that are significantly upregulated in a dose-dependent fashion have been reported as p53 responsive genes, suggesting that cell cycle regulation and p53 activation are involved in the response to SM exposure in the lung.	Samarium	210-212	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	163-166
15388249-3	2004	The vanilloid olvanil reduces SM-induced edema and mRNA expression of cytokines and chemokines, suggesting that blocking the inflammatory effects of neuropeptides, such as substance P (SP), may provide protection against SM-induced dermal injury.	Samarium	30-32	tachykinin 1	Mus musculus	185-187
15388249-3	2004	The vanilloid olvanil reduces SM-induced edema and mRNA expression of cytokines and chemokines, suggesting that blocking the inflammatory effects of neuropeptides, such as substance P (SP), may provide protection against SM-induced dermal injury.	Samarium	221-223	tachykinin 1	Mus musculus	172-183
15388249-3	2004	The vanilloid olvanil reduces SM-induced edema and mRNA expression of cytokines and chemokines, suggesting that blocking the inflammatory effects of neuropeptides, such as substance P (SP), may provide protection against SM-induced dermal injury.	Samarium	221-223	tachykinin 1	Mus musculus	185-187
15388249-10	2004	This study demonstrates that SP expression could provide an additional endpoint for evaluating the effectiveness of vanilloid drugs on SM-induced skin inflammation.	Samarium	135-137	tachykinin 1	Mus musculus	29-31
15251176-9	2004	When cells exposed to 200 microM SM were treated with the p38 MAP kinase inhibitor SB203580, the levels of IL-8, IL-6, and TNF-alpha and IL-1beta were significantly decreased when compared with cells that were untreated.	Samarium	33-35	mitogen-activated protein kinase 14	Homo sapiens	58-61
15371834-9	2004	The OR for positive SMs in patients undergoing NS-RP was 0.86 (95% CI 0.76 to 0.97, p = 0.012) after incorporating age, clinical stage, biopsy grade, year of surgery and prostate specific antigen.	Samarium	20-23	kallikrein related peptidase 3	Homo sapiens	170-195
15251176-2	2004	Previous work has revealed that SM induces the production of inflammatory cytokines, including IL-8, IL-6, TNF-alpha, and IL-1beta, in keratinocytes.	Samarium	32-34	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
15251176-9	2004	When cells exposed to 200 microM SM were treated with the p38 MAP kinase inhibitor SB203580, the levels of IL-8, IL-6, and TNF-alpha and IL-1beta were significantly decreased when compared with cells that were untreated.	Samarium	33-35	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
15251176-2	2004	Previous work has revealed that SM induces the production of inflammatory cytokines, including IL-8, IL-6, TNF-alpha, and IL-1beta, in keratinocytes.	Samarium	32-34	interleukin 6	Homo sapiens	101-105
15251176-2	2004	Previous work has revealed that SM induces the production of inflammatory cytokines, including IL-8, IL-6, TNF-alpha, and IL-1beta, in keratinocytes.	Samarium	32-34	tumor necrosis factor	Homo sapiens	107-116
15251176-9	2004	When cells exposed to 200 microM SM were treated with the p38 MAP kinase inhibitor SB203580, the levels of IL-8, IL-6, and TNF-alpha and IL-1beta were significantly decreased when compared with cells that were untreated.	Samarium	33-35	interleukin 6	Homo sapiens	113-117
15251176-2	2004	Previous work has revealed that SM induces the production of inflammatory cytokines, including IL-8, IL-6, TNF-alpha, and IL-1beta, in keratinocytes.	Samarium	32-34	interleukin 1 beta	Homo sapiens	122-130
15251176-9	2004	When cells exposed to 200 microM SM were treated with the p38 MAP kinase inhibitor SB203580, the levels of IL-8, IL-6, and TNF-alpha and IL-1beta were significantly decreased when compared with cells that were untreated.	Samarium	33-35	tumor necrosis factor	Homo sapiens	123-132
15251176-9	2004	When cells exposed to 200 microM SM were treated with the p38 MAP kinase inhibitor SB203580, the levels of IL-8, IL-6, and TNF-alpha and IL-1beta were significantly decreased when compared with cells that were untreated.	Samarium	33-35	interleukin 1 beta	Homo sapiens	137-145
12083423-3	2002	Compound screening conducted by the US Army Medical Research Institute of Chemical Defense established that topical application of three tested serine protease inhibitors could reduce SM toxicity in the mouse ear vesicant model.	Samarium	184-186	complement component 1, s subcomponent 1	Mus musculus	144-159
15020082-1	2004	The somatostatin analog SMS 201-995 inhibits human peripheral blood lymphocytes (PBL) proliferation and here we demonstrate that it induces a significant increase in T cells IL-10 release as is evidenced in double fluorescence experiments.	Samarium	24-27	interleukin 10	Homo sapiens	174-179
15020082-3	2004	We previously demonstrated that SMS inhibits T cells acting on the CD28 rather than the CD3-mediated signal in exactly the same way as does IL-10.	Samarium	32-35	CD28 molecule	Homo sapiens	67-71
15072626-7	2004	RESULTS: The overall rate of SM+ was 12.8% in pT2 and 31.8% in pT3 tumors.	Samarium	29-32	zinc finger protein 135	Homo sapiens	63-66
12949783-8	2003	In the caudal ventrolateral medulla and nucleus tractus solitarius, Fos-positive neurons projected to the Sm, PB, and LH.	Samarium	106-108	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	68-71
12083423-9	2002	The suppression of SM-increased IL-8 by a class of drug candidate compounds such as protease inhibitors may provide a mechanistic marker that helps predict future medical countermeasures for SM toxicity and reduces the need for testing in animal models.	Samarium	19-21	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
11145574-1	2001	Somatostatin, or its structural analog SMS 201-995 (SMS), is recognized to exert a growth-inhibitory action in rat pancreas, but the cellular mechanisms are not completely understood.	Samarium	39-42	somatostatin	Rattus norvegicus	0-12
11562067-4	2001	On the contrary, SMS, given both in vivo and in vitro, down-regulated the late process (at 72 h) of nuclear fragmentation, induced by anti-CD3 mAb, minimizing simultaneously the elimination of DP cells (expressed both as percentage and absolute number).	Samarium	17-20	CD3 antigen, epsilon polypeptide	Mus musculus	139-142
10779437-8	2000	Exogenous SM failed to augment apoptosis induced by growth factor withdrawal in pgp+ve TF1 cells and was significantly more effective at augmenting apoptosis in pgp-ve patient blasts (median increase in cell death: 33%; range: 19%-88%) than in pgp+ve samples (median: 7%; range: 0%-27%; P =.028).	Samarium	10-12	ATP binding cassette subfamily B member 1	Homo sapiens	161-164
11135666-4	2001	A SMA-causing point mutation (E134K) within the SMN Tudor domain prevents Sm binding.	Samarium	74-76	survival of motor neuron 1, telomeric	Homo sapiens	48-51
11107126-8	2000	Compared to parental lines, 4-HPR achieved 1-3 log greater cell kills in RA-resistant LHN 12X RR, LA-N-5 12X RR, KCNR 12X RR, and MYCN-transduced SMS-LHN or SK-N-RA.	Samarium	146-149	haptoglobin-related protein	Homo sapiens	30-33
11107126-8	2000	Compared to parental lines, 4-HPR achieved 1-3 log greater cell kills in RA-resistant LHN 12X RR, LA-N-5 12X RR, KCNR 12X RR, and MYCN-transduced SMS-LHN or SK-N-RA.	Samarium	146-149	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	130-134
10799564-6	2000	In SV40-WI38, on the other hand, sphingomyelinase washout induced resynthesis of SM due to the action of SMS on ceramide generated at the plasma membrane.	Samarium	81-83	spermine synthase	Homo sapiens	105-108
10779437-8	2000	Exogenous SM failed to augment apoptosis induced by growth factor withdrawal in pgp+ve TF1 cells and was significantly more effective at augmenting apoptosis in pgp-ve patient blasts (median increase in cell death: 33%; range: 19%-88%) than in pgp+ve samples (median: 7%; range: 0%-27%; P =.028).	Samarium	10-12	ATP binding cassette subfamily B member 1	Homo sapiens	161-164
10779437-11	2000	These results indicate that pgp is able to exert a protective effect on AML cell viability and that this is associated with a reduced effect of exogenous SM on apoptosis.	Samarium	154-156	ATP binding cassette subfamily B member 1	Homo sapiens	28-31
10400785-8	1999	SM is also shown to be associated in vivo with other components of the CRM 1 export pathway, including the small GTPase Ran and the nucleoporin CAN/Nup214.	Samarium	0-2	exportin 1	Homo sapiens	71-76
10585747-8	1999	The CEA concentration was determined by measuring the solution fluorescence of 643 nm from the samarium-labeled SA-BSA.	Samarium	95-103	CEA cell adhesion molecule 3	Homo sapiens	4-7
10400785-8	1999	SM is also shown to be associated in vivo with other components of the CRM 1 export pathway, including the small GTPase Ran and the nucleoporin CAN/Nup214.	Samarium	0-2	RAN, member RAS oncogene family	Homo sapiens	120-123
10400785-8	1999	SM is also shown to be associated in vivo with other components of the CRM 1 export pathway, including the small GTPase Ran and the nucleoporin CAN/Nup214.	Samarium	0-2	nucleoporin 214	Homo sapiens	144-154
10344760-5	1999	Cyclin D1 was not expressed in normal bronchial epithelium but was detected in 7% of SMs, 15% of atypias; 18% of LGDs, 47% of HGDs, and 42% of SCCs.	Samarium	85-88	cyclin D1	Homo sapiens	0-9
8807259-6	1996	The sensitivity of ER analysis of SMs and CBs in each fixative compared to formalin-fixed paraffin-embedded tissue sections were as follows: SM (SH) 88%, SM (ETH) 14%, CB (SH) 58%, CB (ETH) 43%, and CB (FOR) 70%.	Samarium	34-37	estrogen receptor 1	Homo sapiens	19-21
9927304-1	1999	Somatostatin (SS-14) and its structural analogue SMS 201-995 (SMS) are recognized as physiological inhibitors of multiple organs and tissue functions through specific membrane receptors (sst1-sst5).	Samarium	49-52	somatostatin	Homo sapiens	0-12
9927304-5	1999	SS-14 and SMS caused significant increases in total cellular PTPase activity, and particularly SHP-1, with maximal activation within 1 min.	Samarium	10-13	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	95-100
9927304-6	1999	Inhibition of membrane tyrosine kinase and p42 MAP kinase activities was also observed, in response to SS-14 and SMS.	Samarium	113-116	cyclin dependent kinase 20	Homo sapiens	43-46
9528992-7	1998	The sphingomyelin (N-acylsphingosine-1-phosphocholine, SM) pathway that is initiated by the hydrolysis of SM to ceramide (Cer) has been shown previously to be activated by the Fas ligand/receptor system in a number of different cell types.	Samarium	55-57	Fas ligand	Rattus norvegicus	176-186
9528992-7	1998	The sphingomyelin (N-acylsphingosine-1-phosphocholine, SM) pathway that is initiated by the hydrolysis of SM to ceramide (Cer) has been shown previously to be activated by the Fas ligand/receptor system in a number of different cell types.	Samarium	106-108	Fas ligand	Rattus norvegicus	176-186
9660096-8	1998	The present study suggests that SM-9018 and its metabolite ID-15036 show a preferential tendency to occupy 5-HT2A receptors, and that the clozapine-like atypical properties of SM-9018 may be due to some pharmacological action of both the SM-9018 itself and its metabolite, ID-15063.	Samarium	32-34	5-hydroxytryptamine receptor 2A	Rattus norvegicus	107-113
9348274-12	1997	EGF also reverses the down-regulating effects of the somatostatin analogue Octreotide (SMS) post resection.	Samarium	87-90	epidermal growth factor	Homo sapiens	0-3
8862081-12	1996	EGF reverses this effect and may benefit patients with SBS who require SMS to control high intestinal output.	Samarium	71-74	epidermal growth factor	Homo sapiens	0-3
9869656-3	1999	The role of oxysterol binding protein (OSBP), a high affinity receptor for 25-hydroxycholesterol, in activation of SM synthesis was assessed by overexpression in CHO-K1 cells.	Samarium	115-117	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	12-37
9869656-3	1999	The role of oxysterol binding protein (OSBP), a high affinity receptor for 25-hydroxycholesterol, in activation of SM synthesis was assessed by overexpression in CHO-K1 cells.	Samarium	115-117	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	39-43
9682269-12	1998	These results indicate that the reduced activity of SM-12502 S-oxidase and no activity of coumarin 7-hydroxylase are caused by the lack of CYP2A6 mRNA and CYP2A6 protein caused by the CYP2A6 gene deletion.	Samarium	52-54	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	139-145
9682269-12	1998	These results indicate that the reduced activity of SM-12502 S-oxidase and no activity of coumarin 7-hydroxylase are caused by the lack of CYP2A6 mRNA and CYP2A6 protein caused by the CYP2A6 gene deletion.	Samarium	52-54	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	155-161
9682269-12	1998	These results indicate that the reduced activity of SM-12502 S-oxidase and no activity of coumarin 7-hydroxylase are caused by the lack of CYP2A6 mRNA and CYP2A6 protein caused by the CYP2A6 gene deletion.	Samarium	52-54	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	155-161
7762657-4	1995	SS-28 and SS-14, cyclo-SS-8, and SS analogue D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-ol [SMS-(201-995) (octreotide)] inhibited 125I-cyclo-SS-8 binding with relative potencies of SS-28 = cyclo-SS-8 = SMS-(201-995) (octreotide), and the binding was not affected by the addition of protease inhibitors.	Samarium	85-88	somatostatin	Cavia porcellus	0-2
8675565-3	1996	SMS 201-995 (SMS), significantly potentiates their GH response to subsequent GHRH challenge.	Samarium	0-3	growth hormone 1	Homo sapiens	51-53
8675565-3	1996	SMS 201-995 (SMS), significantly potentiates their GH response to subsequent GHRH challenge.	Samarium	0-3	growth hormone releasing hormone	Homo sapiens	77-81
8675565-8	1996	Pretreatment with SMS significantly augmented the GH peak response and the GH area under the GH concentration curve over 2 h after GHRH injection in the NSSA group, compared with control tests, but had no effect in the other two groups.	Samarium	18-21	growth hormone 1	Homo sapiens	50-52
8675565-8	1996	Pretreatment with SMS significantly augmented the GH peak response and the GH area under the GH concentration curve over 2 h after GHRH injection in the NSSA group, compared with control tests, but had no effect in the other two groups.	Samarium	18-21	growth hormone 1	Homo sapiens	75-77
8675565-8	1996	Pretreatment with SMS significantly augmented the GH peak response and the GH area under the GH concentration curve over 2 h after GHRH injection in the NSSA group, compared with control tests, but had no effect in the other two groups.	Samarium	18-21	growth hormone 1	Homo sapiens	75-77
8675565-8	1996	Pretreatment with SMS significantly augmented the GH peak response and the GH area under the GH concentration curve over 2 h after GHRH injection in the NSSA group, compared with control tests, but had no effect in the other two groups.	Samarium	18-21	growth hormone releasing hormone	Homo sapiens	131-135
8738483-4	1996	In culture, GH-secreting tumours expressing gsp oncogenes respond more efficiently to the somatostatin analogue, octreotide (SMS), raising the possibility that acromegalics harbouring gsp-positive tumours may be those who optimally benefit from SMS therapy.	Samarium	125-128	GNAS complex locus	Homo sapiens	44-47
8738483-4	1996	In culture, GH-secreting tumours expressing gsp oncogenes respond more efficiently to the somatostatin analogue, octreotide (SMS), raising the possibility that acromegalics harbouring gsp-positive tumours may be those who optimally benefit from SMS therapy.	Samarium	245-248	GNAS complex locus	Homo sapiens	44-47
8961379-5	1996	We conclude that bcl-2- B lymphocytes are submitted to antigen selection in the inflamed SMs while bcl-2 protein expression provides survival signals for their persistence in the infiltrates.	Samarium	89-92	BCL2 apoptosis regulator	Homo sapiens	17-22
7500646-7	1995	In ALL cells, IL-7-induced proliferation was suppressed by SMS in 3/7 cases.	Samarium	59-62	interleukin 7	Homo sapiens	14-18
7878677-10	1995	These results suggest a Ca(2+)-mediated toxic mechanism of SM via PLA2 activation and arachidonate release.	Samarium	59-61	phospholipase A2, group V	Mus musculus	66-70
7642173-11	1995	We therefore conclude that long-term treatment of acromegalic patients with SMS, which achieves a successful reduction of GH and IGF1 levels, does not always guarantee a significant improvement in glucose metabolism.	Samarium	76-79	insulin like growth factor 1	Homo sapiens	129-133
7750900-1	1995	We previously reported that the octapeptide somatostatin (SS) analogue SMS 201-995 (SMS) unexpectedly stimulates the growth of A431 human epidermoid carcinoma cells in vitro.	Samarium	71-74	somatostatin	Homo sapiens	44-56
7750900-6	1995	The serum epidermal growth factor (EGF) level of the SMS-treated mice was significantly lower than that of the untreated mice.	Samarium	53-56	epidermal growth factor	Mus musculus	10-33
7750900-6	1995	The serum epidermal growth factor (EGF) level of the SMS-treated mice was significantly lower than that of the untreated mice.	Samarium	53-56	epidermal growth factor	Mus musculus	35-38
7750900-7	1995	Decreases in serum EGF may attenuate the proliferative effect of SMS in vivo.	Samarium	65-68	epidermal growth factor	Mus musculus	19-22
7628916-2	1995	The data have shown that SMS in vivo decreases the proportion of CD4+, CD5+ and Ig+ cells in spleen.	Samarium	25-28	CD4 molecule	Homo sapiens	65-68
7628916-2	1995	The data have shown that SMS in vivo decreases the proportion of CD4+, CD5+ and Ig+ cells in spleen.	Samarium	25-28	CD5 molecule	Homo sapiens	71-74
7628916-6	1995	The data obtained in vitro revealed that SMS may inhibit only the CD2-induced blastogenesis (in early and late interval after the use of PHA).	Samarium	41-44	CD2 molecule	Homo sapiens	66-69
7506741-3	1994	In the present study, sera from two patients with SMS was used in an immunoblotting assay with recombinant GAD67 (M(r) 67,000) and GAD65 (M(r) 65,000) isoforms to test whether SMS sera can recognize specific epitopes.	Samarium	50-53	glutamate decarboxylase 1	Homo sapiens	107-112
7982482-1	1994	Somatostatin and its analogue SMS 201-995 inhibit high voltage-activated (HVA) Ca2+ currents in the rat insulinoma cell line RINm5F which stably express cloned human somatostatin receptor subtype 2 (hSSTR2).	Samarium	30-33	somatostatin	Rattus norvegicus	0-12
7982482-1	1994	Somatostatin and its analogue SMS 201-995 inhibit high voltage-activated (HVA) Ca2+ currents in the rat insulinoma cell line RINm5F which stably express cloned human somatostatin receptor subtype 2 (hSSTR2).	Samarium	30-33	somatostatin	Homo sapiens	166-178
7982482-1	1994	Somatostatin and its analogue SMS 201-995 inhibit high voltage-activated (HVA) Ca2+ currents in the rat insulinoma cell line RINm5F which stably express cloned human somatostatin receptor subtype 2 (hSSTR2).	Samarium	30-33	somatostatin receptor 2	Homo sapiens	199-205
7506741-3	1994	In the present study, sera from two patients with SMS was used in an immunoblotting assay with recombinant GAD67 (M(r) 67,000) and GAD65 (M(r) 65,000) isoforms to test whether SMS sera can recognize specific epitopes.	Samarium	50-53	glutamate decarboxylase 2	Homo sapiens	131-136
8257527-2	1993	In the present study, we tested the hypothesis that prior administration of the long-acting somatostatin analog, SMS 201-995 (SMS), will enhance GH responsiveness to a subsequent GRF challenge.	Samarium	113-116	growth hormone 1	Homo sapiens	145-147
8257527-2	1993	In the present study, we tested the hypothesis that prior administration of the long-acting somatostatin analog, SMS 201-995 (SMS), will enhance GH responsiveness to a subsequent GRF challenge.	Samarium	113-116	growth hormone releasing hormone	Homo sapiens	179-182
8257527-9	1993	In contrast, in study 2 (n = 25; M = 21, F = 4), whereas spontaneous GH secretion was still suppressed during the 5-h SMS-GRF interval (AUC 1:3.8 +/- 0.4 vs. 7.4 +/- 1.1 micrograms/L.h; P < 0.001), both the GH peak response (56.7 +/- 5.5 vs. 30.5 +/- 3.0 micrograms/L; P < 0.0001) and the GH AUC (AUC 2: 103.7 +/- 10.3 vs. 77.5 +/- 6.8 micrograms/L.h; P < 0.05) after GRF administration were significantly augmented by pretreatment with SMS, compared to control tests.	Samarium	118-121	growth hormone releasing hormone	Homo sapiens	122-125
8257527-10	1993	Taken together, these results indicate that a priming SMS dose of 1 microgram/kg has a significant permissive effect on GH responsiveness to exogenous GRF administered 5 h later.	Samarium	54-57	growth hormone 1	Homo sapiens	120-122
8257527-10	1993	Taken together, these results indicate that a priming SMS dose of 1 microgram/kg has a significant permissive effect on GH responsiveness to exogenous GRF administered 5 h later.	Samarium	54-57	growth hormone releasing hormone	Homo sapiens	151-154
8511502-3	1993	When the famotidine+SMS group was compared with the famotidine group, the G-cell number was significantly decreased (P < 0.01) by approximately 30%, and the serum gastrin level was significantly decreased (P < 0.01) by approximately 40%.	Samarium	20-23	gastrin	Rattus norvegicus	166-173
8491320-2	1993	Using the two cell lines which secreted significant amounts of CEA in the media, there was a 40% and 54% decrease in CEA level at 2e-10M and 2e-9M concentrations of SMS 201.995, respectively, after five days of incubation for LIM 2412 cell line (P < 0.05, both).	Samarium	165-168	CEA cell adhesion molecule 3	Homo sapiens	63-66
8491320-2	1993	Using the two cell lines which secreted significant amounts of CEA in the media, there was a 40% and 54% decrease in CEA level at 2e-10M and 2e-9M concentrations of SMS 201.995, respectively, after five days of incubation for LIM 2412 cell line (P < 0.05, both).	Samarium	165-168	CEA cell adhesion molecule 3	Homo sapiens	117-120
8491320-3	1993	There was a 13% decrease in CEA at 2e-9M concentration of SMS with the LoVo cell line (P > 0.05).	Samarium	58-61	CEA cell adhesion molecule 3	Homo sapiens	28-31
8491320-5	1993	When the growth of xenografts was inhibited by SMS, there was a corresponding drop in serum CEA.	Samarium	47-50	CEA cell adhesion molecule 3	Homo sapiens	92-95
8491320-7	1993	Thus, CEA concentration reflected cell number in vitro and tumor size in vivo as a response to treatment with SMS 201.995.	Samarium	110-113	CEA cell adhesion molecule 3	Homo sapiens	6-9
1531654-8	1992	Our data suggest that (i) the Sm-binding site lies on the surface of the native U1 snRNP, since the cross-link in X-U1#1 involves the Sm-binding site but does not block snRNP assembly, and (ii) U1 snRNA may adopt the correct tertiary conformation even in the absence of U1 snRNP proteins.	Samarium	30-32	glutamate receptor KA2 L homeolog	Xenopus laevis	80-88
1329904-3	1992	After incubation with SMS for 24 h, the forskolin-stimulated cAMP synthetic rate in intact cyc- cells was increased by 76%, similar to the increase found in the wild-type cells.	Samarium	22-25	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	91-94
1347515-5	1992	The somatostatin analog SMS 201-995 (SMS) decreased the growth-promoting effect of bFGF.	Samarium	24-27	fibroblast growth factor 2	Rattus norvegicus	83-87
1329904-5	1992	Pretreatment of cyc- cells with pertussis toxin prevented SMS from inducing the enhancement of forskolin-stimulated cAMP accumulation in intact cells.	Samarium	58-61	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	16-19
1513103-5	1992	In non-diabetic rats SMS reduced body weight (274 +/- 3 vs. 293 +/- 5 g, P less than 0.01), kidney weight (695 +/- 9 vs. 764 +/- 17 mg, P less than 0.01), UAE (83 +/- 29 vs. 364 +/- 114 micrograms/24 hr, P less than 0.02), kidney IGF-I (202 +/- 12 vs. 280 +/- 12 ng/g, P less than 0.01), serum IGF-I (428 +/- 21 vs. 601 +/- 54 micrograms/liter, P less than 0.01) and serum rGH (67 +/- 6 vs. 126 +/- 27 micrograms/liter, P less than 0.05) when compared to untreated controls.	Samarium	21-24	insulin-like growth factor 1	Rattus norvegicus	230-235
1513103-5	1992	In non-diabetic rats SMS reduced body weight (274 +/- 3 vs. 293 +/- 5 g, P less than 0.01), kidney weight (695 +/- 9 vs. 764 +/- 17 mg, P less than 0.01), UAE (83 +/- 29 vs. 364 +/- 114 micrograms/24 hr, P less than 0.02), kidney IGF-I (202 +/- 12 vs. 280 +/- 12 ng/g, P less than 0.01), serum IGF-I (428 +/- 21 vs. 601 +/- 54 micrograms/liter, P less than 0.01) and serum rGH (67 +/- 6 vs. 126 +/- 27 micrograms/liter, P less than 0.05) when compared to untreated controls.	Samarium	21-24	insulin-like growth factor 1	Rattus norvegicus	294-299
1513103-8	1992	The long-term suppressive effects of SMS on renal enlargement and UAE may in part be mediated through reduction in circulating and kidney IGF-I levels.	Samarium	37-40	insulin-like growth factor 1	Rattus norvegicus	138-143
1531654-8	1992	Our data suggest that (i) the Sm-binding site lies on the surface of the native U1 snRNP, since the cross-link in X-U1#1 involves the Sm-binding site but does not block snRNP assembly, and (ii) U1 snRNA may adopt the correct tertiary conformation even in the absence of U1 snRNP proteins.	Samarium	30-32	glutamate receptor KA2 L homeolog	Xenopus laevis	270-278
1713051-2	1991	Clinical studies have shown that SMS reduces the peripheral levels of tumour-produced serotonin (5-HT) and tachykinins, e.g. neuropeptide K (NPK), basally and after pentagastrin provocation.	Samarium	33-36	tachykinin precursor 1	Homo sapiens	125-139
1683501-6	1991	The somatostatin analogue SMS 201-995 was found to be a potent inhibitor of the ectopic GHRH and the GH secretion (greater than 500 to 42 ng/l and 15.4 micrograms/l to 0.8 microgram/l, respectively).	Samarium	26-29	growth hormone releasing hormone	Homo sapiens	88-92
1737355-3	1992	Gastrin concentrations used were 5e-10 M and 1e-7 M. SMS concentrations were from 2e-12 M to 2e-7 M. Cell lines LIM 1215, LIM 2405, and LIM 2412 were inhibited dose-dependently in both basal and gastrin-stimulated groups.	Samarium	53-56	gastrin	Homo sapiens	195-202
1713051-2	1991	Clinical studies have shown that SMS reduces the peripheral levels of tumour-produced serotonin (5-HT) and tachykinins, e.g. neuropeptide K (NPK), basally and after pentagastrin provocation.	Samarium	33-36	tachykinin precursor 1	Homo sapiens	141-144
1713051-5	1991	Media levels of 5-HT and NPK-LI in tumour cell cultures decreased rapidly during incubation with SMS (10(-8)-10(-10) M) in all four tumours studied without evidence for tachyphylaxis (up to 6 weeks observation period).	Samarium	97-100	tachykinin precursor 1	Homo sapiens	25-28
2007175-6	1991	It is of particular interest that these lipid species may be involved in the regulation of PK-C, suggesting that SM metabolism could play a role in signal transduction.	Samarium	113-115	proline rich transmembrane protein 2	Homo sapiens	91-95
1947381-7	1991	Inspire of the reducing effect that SMS has on insulin levels, its influence on the blood sugar profile is scare.	Samarium	36-39	insulin	Homo sapiens	47-54
2018120-1	1991	We investigated the effect of a somatostatin analogue octreotide (SMS) on the stimulatory effect of recombinant human growth hormone (hGH) on insulin-like growth factor I (IGF-I) generation and growth in hypophysectomized rats.	Samarium	66-69	growth hormone 1	Homo sapiens	118-132
2018120-1	1991	We investigated the effect of a somatostatin analogue octreotide (SMS) on the stimulatory effect of recombinant human growth hormone (hGH) on insulin-like growth factor I (IGF-I) generation and growth in hypophysectomized rats.	Samarium	66-69	insulin like growth factor 1	Homo sapiens	142-170
2018120-1	1991	We investigated the effect of a somatostatin analogue octreotide (SMS) on the stimulatory effect of recombinant human growth hormone (hGH) on insulin-like growth factor I (IGF-I) generation and growth in hypophysectomized rats.	Samarium	66-69	insulin like growth factor 1	Homo sapiens	172-177
2018120-5	1991	During 11 days of hGH treatment, serum IGF-I increased from 22 +/- 5 to 1,288 +/- 92 micrograms/l (P less than 0.001) but increased only 40% (513 +/- 71 vs. 1,288 +/- 92 micrograms/l, P less than 0.001) when SMS was given in combination with hGH.	Samarium	208-211	insulin-like growth factor 1	Rattus norvegicus	39-44
1705618-6	1991	The overall incidence of inhibition for the somatostatin analogues at concentrations of 0.5, 2.5, and 50 micrograms per disk was 13, 56, and 61% for SMS and 27, 49, and 68% for RC-160, respectively.	Samarium	149-152	somatostatin 1	Gallus gallus	44-56
1982527-7	1990	Competition kinetics using unlabelled SMS 201-995 to displace [125I]SRIF revealed two distinct binding sites in the neuronal preparations (IC50 = 11 +/- 3 pM and 4.5 +/- 0.8 nM).	Samarium	38-41	somatostatin	Mus musculus	68-72
1989869-9	1991	Both iv and ID infusion of SMS during the first 2 h of PJD markedly decreased the plasma PYY concentration to 134 +/- 27 pg/ml and 156 +/- 19 pg/ml, respectively; the total incremental PYY release during 4 h of PJD was inhibited by 100% and 84% by iv and ID SMS, respectively.	Samarium	27-30	peptide YY	Rattus norvegicus	89-92
1989869-9	1991	Both iv and ID infusion of SMS during the first 2 h of PJD markedly decreased the plasma PYY concentration to 134 +/- 27 pg/ml and 156 +/- 19 pg/ml, respectively; the total incremental PYY release during 4 h of PJD was inhibited by 100% and 84% by iv and ID SMS, respectively.	Samarium	27-30	peptide YY	Rattus norvegicus	185-188
2156257-6	1990	The somatostatin analog, SMS, given alone or as a combined regimen with tamoxifen, significantly reduced (a) the rate of growth of SKI, and (b) DNA, RNA, and protein content of the tumors.	Samarium	25-28	somatostatin	Mus musculus	4-16
2276223-3	1990	After eight weeks of SMS 201-995 administration, 24-hour integrated plasma growth hormone concentrations had declined by 47.0 +/- 9.3% of pretreatment values (p less than 0.01), and insulin requirements fell from 40.7 +/- 6.7 units per day to 32.2 +/- 6.9 units per day (p less than 0.01).	Samarium	21-24	growth hormone 1	Homo sapiens	75-89
1970610-5	1990	These results indicate that SM-3997 binds to 5-HT1A receptors of rat brain sections.	Samarium	28-30	5-hydroxytryptamine receptor 1A	Rattus norvegicus	45-51
2402220-4	1990	Treatment for up to 2 years with SMS controlled symptoms, suppressed serum gastrin, and suppressed acid secretion.	Samarium	33-36	gastrin	Homo sapiens	75-82
2121494-4	1990	The initial inhibition of plasma CCK secretion by SMS was cancelled during the 3rd h after the meal, whereas PP release remained completely abolished.	Samarium	50-53	cholecystokinin	Homo sapiens	33-36
2188384-6	1990	We hypothesized that SMS would suppress basal and provoked gastrin and secondary peptide secretion in ZES.	Samarium	21-24	gastrin	Homo sapiens	59-66
2188384-21	1990	SMS may be useful in ZES by suppressing basal and provoked gastrin and secondary peptide secretion and may occasionally give palliation by yielding temporary tumor registration.	Samarium	0-3	gastrin	Homo sapiens	59-66
2140082-4	1990	The SMS infusion induced a reduction in the glomerular filtration rate (clearance of 125I-iothalamate) and renal plasma flow (131I-hippuran) from 140 +/- 15 (mean +/- SD) and 550 +/- 69 to 131 +/- 14 (2p less than 0.005) and 492 +/- 73 ml min-1 1.73-m-2 (2p less than 0.001), while filtration fraction and total renal resistance rose (both 2p less than 0.001).	Samarium	4-7	CD59 molecule (CD59 blood group)	Homo sapiens	239-244
2331811-2	1990	Compared to the basal levels, mean plasma IR-7B2 and GH levels significantly decreased, until 5 and 10 h respectively after the administration of SMS 201-995.	Samarium	146-149	secretogranin V	Homo sapiens	45-48
2166654-8	1990	Although significant rises in plasma ACTH and cortisol levels were observed regardless of the preinjection of SMS, their responses to hCRH were significantly lower with the pretreatment with SMS than without SMS.	Samarium	191-194	proopiomelanocortin	Homo sapiens	37-41
2166654-9	1990	A significant increase in plasma cortisol and aldosterone was observed in response to synthetic ACTH with both ACTH alone and the combined administration of SMS and ACTH, at either dose of ACTH.	Samarium	157-160	proopiomelanocortin	Homo sapiens	96-100
34953167-8	2022	LGI1+/CASPR2+ patients had increased N1 sleep (p=0.02), decreased REM sleep (p=0.001), and higher levels of SM+AT any RSWA (p < 0.001).	Samarium	108-111	leucine rich glioma inactivated 1	Homo sapiens	0-4
1967642-6	1990	Under basal conditions, SS-14 produced a maximum decrease in distal jejunal lsc which was nearly twice that produced by its synthetic analog SMS 201,995 (octreotide); the two peptides inhibited lsc with similar potencies.	Samarium	141-144	somatostatin	Homo sapiens	24-29
1969119-4	1990	The effects of 8-OH-DPAT and SM-3997 on the hippocampal RSA were blocked by pindolol, which has 5-HT1A antagonistic activity.	Samarium	29-32	5-hydroxytryptamine receptor 1A	Oryctolagus cuniculus	96-102
1975107-2	1990	The 5-HT1A agonists 8-OH-DPAT (0.125-1.0 mg/kg, SC) and tandospirone (SM-3997) (5-20 mg/kg, SC) both produced dose-related decreases in immobility time following subchronic treatment in rats.	Samarium	70-72	5-hydroxytryptamine receptor 1A	Rattus norvegicus	4-10
34953167-8	2022	LGI1+/CASPR2+ patients had increased N1 sleep (p=0.02), decreased REM sleep (p=0.001), and higher levels of SM+AT any RSWA (p < 0.001).	Samarium	108-111	contactin associated protein 2	Homo sapiens	6-12
34833976-7	2021	An isotherm study showed that the adsorption data of Pb(II) onto chemically modified SM was fully fitted with the Freundlich and Langmuir isotherm models.	Samarium	85-87	submaxillary gland androgen regulated protein 3B	Homo sapiens	53-59
34811369-10	2021	The GlcCer/SM ratio was negatively associated with alpha-synuclein levels in CSF of PD patients.	Samarium	11-13	synuclein alpha	Homo sapiens	51-66
34351649-7	2021	In a validation set of primary CRCs, JAM3 and IDO1 (p = 0.044 and p = 0.036, respectively) were confirmed to show significant upregulation and downregulation, respectively, in the SM+ group, whereas HIST1H2BK (p = 0.017) was significantly upregulated in the CPM subgroup.	Samarium	180-183	junctional adhesion molecule 3	Homo sapiens	37-41
34351649-7	2021	In a validation set of primary CRCs, JAM3 and IDO1 (p = 0.044 and p = 0.036, respectively) were confirmed to show significant upregulation and downregulation, respectively, in the SM+ group, whereas HIST1H2BK (p = 0.017) was significantly upregulated in the CPM subgroup.	Samarium	180-183	indoleamine 2,3-dioxygenase 1	Homo sapiens	46-50
34824340-6	2021	Moreover, HIV infection caused receptor interacting protein kinase-1 (RIPK1) degradation which in concert with IAP1/2 downregulation following SM treatment may result in apoptosis of macrophages.	Samarium	143-145	receptor interacting serine/threonine kinase 1	Homo sapiens	31-68
34824340-6	2021	Moreover, HIV infection caused receptor interacting protein kinase-1 (RIPK1) degradation which in concert with IAP1/2 downregulation following SM treatment may result in apoptosis of macrophages.	Samarium	143-145	baculoviral IAP repeat containing 3	Homo sapiens	111-117
34747948-6	2021	The present results point towards potential applications of Sm doped CaF2 nanocrystals in the fields of dosimetry and X-ray imaging.	Samarium	60-62	CCR4-NOT transcription complex subunit 8	Homo sapiens	69-73
34833976-10	2021	The adsorption capacity of chemically modified SM for Pb(II) ions was 792 mg/g which is quite high as compared to the traditional adsorbents.	Samarium	47-49	submaxillary gland androgen regulated protein 3B	Homo sapiens	54-60
34833976-11	2021	The adsorbent chemically modified SM was regenerated, used again three times for the adsorption of Pb(II) ions and it was found that the adsorption capacity of the regenerated adsorbent was only dropped by 7%.	Samarium	34-36	submaxillary gland androgen regulated protein 3B	Homo sapiens	99-105
34561230-5	2021	IFN-gamma stimulation conferred on M0 macrophages the sensitivity to SM-induced cell death through the Jak/STAT, IFN regulatory factor-1, and mammalian target of rapamycin complex-1 (mTORC-1)/ribosomal protein S6 kinase pathways.	Samarium	69-71	interferon gamma	Homo sapiens	0-9
34561230-5	2021	IFN-gamma stimulation conferred on M0 macrophages the sensitivity to SM-induced cell death through the Jak/STAT, IFN regulatory factor-1, and mammalian target of rapamycin complex-1 (mTORC-1)/ribosomal protein S6 kinase pathways.	Samarium	69-71	CREB regulated transcription coactivator 1	Mus musculus	183-190
34561230-7	2021	In contrast, SM-induced cell death in polarized M1 macrophages is regulated by the mTORC-2 pathway.	Samarium	13-15	CREB regulated transcription coactivator 2	Mus musculus	83-90
34561230-8	2021	Moreover, SM-induced cell death is regulated by cellular IAP (cIAP)-2, receptor-interacting protein kinase (RIPK)-1, and RIPK-3 degradation through mTORC activation during differentiation into M1 macrophages and in polarized M1 macrophages.	Samarium	10-12	baculoviral IAP repeat containing 3	Homo sapiens	48-69
34561230-8	2021	Moreover, SM-induced cell death is regulated by cellular IAP (cIAP)-2, receptor-interacting protein kinase (RIPK)-1, and RIPK-3 degradation through mTORC activation during differentiation into M1 macrophages and in polarized M1 macrophages.	Samarium	10-12	receptor interacting serine/threonine kinase 1	Homo sapiens	71-115
34561230-8	2021	Moreover, SM-induced cell death is regulated by cellular IAP (cIAP)-2, receptor-interacting protein kinase (RIPK)-1, and RIPK-3 degradation through mTORC activation during differentiation into M1 macrophages and in polarized M1 macrophages.	Samarium	10-12	receptor interacting serine/threonine kinase 3	Homo sapiens	121-127
34561230-9	2021	In contrast to cancer cell lines, SM-induced cell death in M1 macrophages is independent of endogenously produced TNF-alpha, as well as the NF-kappaB pathway.	Samarium	34-36	nuclear factor kappa B subunit 1	Homo sapiens	140-149
34587217-7	2021	The percentage of time spent above the criterion HR was also significantly lower in SM-20:10 compared to all other protocols (Ergo-60:60 13.9+-4.9min, BW-60:60 13.5+-3.5min, SM-40:20 12.1+-2.4min, SM-20:10 7.7+-3.1, P<0.05).	Samarium	174-176	egl-9 family hypoxia inducible factor 1	Homo sapiens	84-89
34484674-6	2021	The XLOC_001659/miR-98-5p/MAP3K2 axis uniformly mediated the regulation of SM-SiO2s on proliferation of HCC, NSCLC and BC cells.	Samarium	75-77	microRNA 98	Homo sapiens	16-22
34081961-7	2021	SM exposure upregulated keratin 17 expression.	Samarium	0-2	keratin, type I cytoskeletal 17	Oryctolagus cuniculus	24-34
34085356-7	2021	Each of them also carried a rare variant on the other allele that either disrupts the secondary structure or the Sm binding site of the RNU12 snRNA.	Samarium	113-115	RNA, U1 small nuclear 2	Homo sapiens	136-141
34506503-10	2021	This was observed in both the SMS group (IRR = 1 41,1 21-1 64, p<0 001) and in the non-SMS group (IRR = 1 37,1 18-1 61, p<0 001).	Samarium	30-33	insulin receptor related receptor	Homo sapiens	41-44
34484674-6	2021	The XLOC_001659/miR-98-5p/MAP3K2 axis uniformly mediated the regulation of SM-SiO2s on proliferation of HCC, NSCLC and BC cells.	Samarium	75-77	mitogen-activated protein kinase kinase kinase 2	Homo sapiens	26-32
2569769-7	1989	We conclude that SMS slows the growth of both MCF-7 and BT-20 human breast cancer xenografts in nude mice and that SMS may be clinically useful in the management of patients with breast carcinoma.	Samarium	17-20	immunoglobulin kappa variable 17-121	Mus musculus	56-61
35612992-6	2022	Urinary metabolites significantly associated with urine and serum uromodulin were used to build weighted metabolite scores for urine (uMS) and serum uromodulin (sMS) and evaluated for time to adverse kidney events over 6.5 years.	Samarium	161-164	uromodulin	Homo sapiens	66-76
35612992-6	2022	Urinary metabolites significantly associated with urine and serum uromodulin were used to build weighted metabolite scores for urine (uMS) and serum uromodulin (sMS) and evaluated for time to adverse kidney events over 6.5 years.	Samarium	161-164	uromodulin	Homo sapiens	149-159
35545264-4	2022	Reaction of Sm+ also yields SmO+ at near the capture limit at all temperatures, but a significant fraction (~50%) of the SmO+ is produced in excited states that are long-lived compared to the millisecond time scale of the experiment.	Samarium	12-15	smoothened, frizzled class receptor	Homo sapiens	28-31
35545264-4	2022	Reaction of Sm+ also yields SmO+ at near the capture limit at all temperatures, but a significant fraction (~50%) of the SmO+ is produced in excited states that are long-lived compared to the millisecond time scale of the experiment.	Samarium	12-15	smoothened, frizzled class receptor	Homo sapiens	121-124
35259100-0	2022	Sputter Deposition and Characterization of Sm-Doped Pb(Mg1/3, Nb2/3)O3-PbTiO3 Epitaxial Thin Film on Si toward Giant-Piezoelectric Thin Film for MEMS Actuator Application.	Samarium	43-45	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	55-60
35503176-4	2022	SMS family members not only influence SM levels but also influence the levels of diacylglycerol (DAG), PC, PE, and glycosphingolipids, thus influencing cell functions.	Samarium	38-40	spermine synthase	Homo sapiens	0-3
2518866-7	1989	Peptone meal-stimulated plasma gastrin concentrations were inhibited for 5 and 7 h after 50-micrograms and 100-micrograms doses of SMS 201-995, respectively, whereas "basal" plasma gastrins were inhibited for 4 and 6 h, respectively.	Samarium	131-134	gastrin	Homo sapiens	31-38
35543325-2	2022	Because Sm is divalent in BaAl12O19 and trivalent in SrAl12O19, the coexistence of Sm2+ and Sm3+ is realized in the mixed-phase host.	Samarium	8-10	SM2	Homo sapiens	83-86
32031506-4	2022	Among the 36.5% of SM who self-identified needing counseling, percentages of SMs receiving counseling were lower among those perceiving stigma associated with BH services (51.0%) than those not perceiving stigma (66.7%).	Samarium	77-80	bleomycin hydrolase	Homo sapiens	159-161
2760170-7	1989	We conclude that during long term treatment of acromegalics with SMS, an injection of 100 micrograms, sc, completely abolishes gallbladder contraction for at least 2 h after a standard breakfast, despite blunted, but still significant, CCK release.	Samarium	65-68	cholecystokinin	Homo sapiens	236-239
2760170-8	1989	The data suggest a decreased sensitivity of the gallbladder to endogenous CCK during long term treatment with SMS.	Samarium	110-113	cholecystokinin	Homo sapiens	74-77
3194831-5	1988	In a second experiment serum gastrin was measured 30 minutes after injection of somatostatin analogue, SMS 201-995 (300 micrograms/kg).	Samarium	103-106	gastrin	Mus musculus	29-36
2671112-7	1989	The premeal injection of SMS decreases postprandial glycemic excursions and the corresponding insulin requirement.	Samarium	25-28	insulin	Homo sapiens	94-101
2563240-3	1989	SMS induced an antiproliferative effect on both serum or epidermal growth factor (EGF)-induced cell proliferation; exposure of the cells for 48 h to SMS caused a slight inhibition of serum-induced proliferation (maximal inhibition, 26%) and abolished the growth-promoting effect of EGF.	Samarium	0-3	epidermal growth factor like 1	Rattus norvegicus	57-80
2563240-3	1989	SMS induced an antiproliferative effect on both serum or epidermal growth factor (EGF)-induced cell proliferation; exposure of the cells for 48 h to SMS caused a slight inhibition of serum-induced proliferation (maximal inhibition, 26%) and abolished the growth-promoting effect of EGF.	Samarium	0-3	epidermal growth factor like 1	Rattus norvegicus	82-85
2563240-3	1989	SMS induced an antiproliferative effect on both serum or epidermal growth factor (EGF)-induced cell proliferation; exposure of the cells for 48 h to SMS caused a slight inhibition of serum-induced proliferation (maximal inhibition, 26%) and abolished the growth-promoting effect of EGF.	Samarium	0-3	epidermal growth factor like 1	Rattus norvegicus	282-285
2563240-3	1989	SMS induced an antiproliferative effect on both serum or epidermal growth factor (EGF)-induced cell proliferation; exposure of the cells for 48 h to SMS caused a slight inhibition of serum-induced proliferation (maximal inhibition, 26%) and abolished the growth-promoting effect of EGF.	Samarium	149-152	epidermal growth factor like 1	Rattus norvegicus	282-285
2563240-11	1989	SMS had no effect on basal cAMP, but completely inhibited VIP-stimulated cAMP production with an IC50 of 0.2 nM.	Samarium	0-3	vasoactive intestinal peptide	Rattus norvegicus	58-61
2897069-6	1988	Infusion of SRIF with T (5 mg/kg/d) blunted the stimulatory effect of T. Similarly, infusion of a high dose of SMS (13 micrograms/kg/d), together with T (15 mg/kg/d), abolished the effect of T (15 mg/kg/d) without altering serum glucose or mineral levels.	Samarium	111-114	somatostatin	Mus musculus	12-16
2903562-6	1988	Treatment for up to 12 months with SMS 201-995 controlled symptoms in six of eight patients, suppressed serum gastrin in three of five, and suppressed acid secretion in three of three patients.	Samarium	35-38	gastrin	Homo sapiens	110-117
2903562-7	1988	Treatment with SMS 201-995 in three patients for 5 months decreased tumor secretion of gastrin and diminished basal acid secretion, an effect that persisted in two of three patients 48 hours after withdrawal of SMS.	Samarium	15-18	gastrin	Homo sapiens	87-94
2903562-10	1988	We conclude that SMS may be useful in the management of gastrinoma patients by decreasing hypersecretion of gastrin and gastric acid and, over a longer term, may even change tumor capacity to release gastrin and gastric acid secretion.	Samarium	17-20	gastrin	Homo sapiens	56-63
2903562-10	1988	We conclude that SMS may be useful in the management of gastrinoma patients by decreasing hypersecretion of gastrin and gastric acid and, over a longer term, may even change tumor capacity to release gastrin and gastric acid secretion.	Samarium	17-20	gastrin	Homo sapiens	108-115
3139421-5	1988	As compared to omeprazole alone, simultaneous SMS administration significantly decreased the parietal cell (P less than 0.05) and gastrin cell (P less than 0.01) labelling indices, mucosal height of total glandular stomach (P less than 0.05) and antral mucosal height (P less than 0.05).	Samarium	46-49	gastrin	Rattus norvegicus	130-137
2890182-8	1987	CCl4 changed the lipid composition of the liver plasma membrane by increasing PI and PC and decreasing SM, PS and PEA.	Samarium	103-105	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
2889358-7	1987	Serum motilin levels decreased significantly from 126 pg/ml before injection of SMS 201-995 to 52 pg/ml after injection.	Samarium	80-83	motilin	Homo sapiens	6-13
2900190-1	1988	Ten acromegalics received daily doses of 200-300 micrograms of a long-acting somatostatin analog, SMS 201-995 (Sandostatin, SMS), for an average of 64 weeks.	Samarium	98-101	somatostatin	Homo sapiens	77-89
2890795-10	1987	Pharmacologic levels of SMS 201,995 and L 363,568 were reliably achieved in portal blood and the latter produced significant reduction (P less than 0.05) in portal venous levels of gastrin.	Samarium	24-27	gastrin	Sus scrofa	181-188
2876492-6	1986	Insulin and glucagon levels fell markedly in response to SMS administration, and the blood concentration and splanchnic output of glucose decreased transiently.	Samarium	57-60	insulin	Homo sapiens	0-7
2884879-5	1987	The release of pancreatic polypeptide by a solid test meal is abolished by administration of 25 micrograms of SMS, the release of gastric inhibitory polypeptide is nearly completely suppressed, the response of insulin and C-peptide are significantly lowered, and the gastrin response is only slightly reduced.	Samarium	110-113	pancreatic polypeptide	Homo sapiens	15-37
2884879-5	1987	The release of pancreatic polypeptide by a solid test meal is abolished by administration of 25 micrograms of SMS, the release of gastric inhibitory polypeptide is nearly completely suppressed, the response of insulin and C-peptide are significantly lowered, and the gastrin response is only slightly reduced.	Samarium	110-113	insulin	Homo sapiens	210-217
2884879-5	1987	The release of pancreatic polypeptide by a solid test meal is abolished by administration of 25 micrograms of SMS, the release of gastric inhibitory polypeptide is nearly completely suppressed, the response of insulin and C-peptide are significantly lowered, and the gastrin response is only slightly reduced.	Samarium	110-113	gastrin	Homo sapiens	267-274
2880861-4	1987	Chronic treatment [60-330 days; mean 208 +/- 23 (+/- SEM)] with SMS (100-300 micrograms/day) induced in 16 patients a significantly greater decrease in mean plasma GH and somatomedin-C levels than did 20 mg Brc.	Samarium	64-67	insulin like growth factor 1	Homo sapiens	171-184
2892339-6	1987	The postprandial rise of insulin levels was reversed by SMS, leading to a more pronounced postprandial rise of glucose, whereas the postprandial secretion of glucagon was also reversed by SMS.	Samarium	56-59	insulin	Homo sapiens	25-32
2879447-2	1986	A single 50-micrograms dose of SMS 201-995 effectively controlled gastric acid and blood gastrin levels for 12 hours in three patients with benign gastrinomas and was useful in their perioperative management.	Samarium	31-34	gastrin	Homo sapiens	89-96
2879448-3	1986	The current study examined the effect of SMS 201-995 on gastrin secretion from gastrinoma in vitro.	Samarium	41-44	gastrin	Homo sapiens	56-63
2879448-5	1986	In cell culture, SMS 201-995 at 10(-9) M, 10(-8) M, and 10(-7) M significantly stimulated gastrin secretion (basal medium gastrin, 157 +/- 7.9 pg/ml; with SMS 201-995 10(-9) M, 786 +/- 62 pg/ml; with SMS 201-995 10(-8) M, 569 +/- 72 pg/ml; and with SMS 201-995 10(-7) M, 258 +/- 26 pg/ml).	Samarium	17-20	gastrin	Homo sapiens	90-97
2879448-5	1986	In cell culture, SMS 201-995 at 10(-9) M, 10(-8) M, and 10(-7) M significantly stimulated gastrin secretion (basal medium gastrin, 157 +/- 7.9 pg/ml; with SMS 201-995 10(-9) M, 786 +/- 62 pg/ml; with SMS 201-995 10(-8) M, 569 +/- 72 pg/ml; and with SMS 201-995 10(-7) M, 258 +/- 26 pg/ml).	Samarium	17-20	gastrin	Homo sapiens	122-129
2878748-2	1986	In the present study it was investigated whether PRL release in prolactinoma and acromegalic patients might also be sensitive to SMS 201-995 and whether co-secretion of PRL in acromegaly plays a role in determining the sensitivity of GH secretion to SMS 201-995.	Samarium	129-132	prolactin	Homo sapiens	49-52
2876501-7	1986	Preliminary data suggest that 50 micrograms SMS 201-995 subcutaneously at night inhibits the nocturnal rise in GH secretion in normal man, but no effect on 24-h GH secretion is observed when SMS 201-995 is injected twice daily before meals.	Samarium	44-47	growth hormone 1	Homo sapiens	111-113
2860119-0	1985	The somatostatin analog SMS 201-995 induces long-acting inhibition of growth hormone secretion without rebound hypersecretion in acromegalic patients.	Samarium	24-27	growth hormone 1	Homo sapiens	70-84
33592213-6	2021	RESULTS: Total and subspecies of serum SMs and globotriaosyl ceramides (Gb3s) were positively related to GIR30, free FAs (FFA 16:1, FFA20:4), some long chain GM3 and complex ceramide GluCers showed strong negative correlations with GIR30.	Samarium	39-42	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	72-76
6343334-4	1983	The Tp R-plasmids carried a diversity of resistance determinants such as Tc, Cm, Sp, Sm and Su.	Samarium	85-87	translocated promoter region, nuclear basket protein	Homo sapiens	4-8
146819-2	1978	The sulfonamide (Su) and streptomycin/spectinomycin (Sm/Sp) resistance genes are located on EcoRI fragment G of NR1.	Samarium	53-55	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	112-115
713872-6	1978	Sm) (Tc, tetracycline; Sm, streptomycin) resistance mediate the formation of this type of DHPS.	Samarium	0-2	dihydropteroate synthetase	Escherichia coli	90-94
33961028-5	2021	Crystal structures show that the short cellular SMs stabilized a triad of surface residues to remain flush with CD1a, but the longer lipids forced the phosphocholine group to ride above the display platform to hinder TCR approach.	Samarium	48-51	CD1a molecule	Homo sapiens	112-116
32791755-10	2020	CONCLUSIONS: Patients taking the DSM therapy had better effects in reducing the level of HbA1c, FPG, body weight, SBP and DBP than the DM and SM therapy.	Samarium	34-36	selenium binding protein 1	Homo sapiens	114-117
33404106-6	2021	SM-induced cell death in M1 Mphis was mediated by apoptosis as well as necroptosis, activated both extrinsic and intrinsic pathways of apoptosis, and was attributed to the IFN-gamma-mediated differentiation.	Samarium	0-2	interferon gamma	Homo sapiens	172-181
33136349-3	2020	In this work, a facile additive strategy is devised by introducing bifunctional guanidine sulfamate (GuaSM; CH6 N3 + , Gua+ ; H2 N-SO3 - , SM- ) into PVK.	Samarium	139-142	DExD-box helicase 21	Homo sapiens	101-104
33114200-6	2020	Surprisingly, it was found that SM significantly enhanced LPS-induced expression of the pro-inflammatory cytokines interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) in RAW264.7 cells via activation of the c-Jun/Toll-like receptor 4 (TLR4) signaling axis.	Samarium	32-34	interleukin 6	Mus musculus	115-128
33114200-6	2020	Surprisingly, it was found that SM significantly enhanced LPS-induced expression of the pro-inflammatory cytokines interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) in RAW264.7 cells via activation of the c-Jun/Toll-like receptor 4 (TLR4) signaling axis.	Samarium	32-34	interleukin 6	Mus musculus	130-134
33114200-6	2020	Surprisingly, it was found that SM significantly enhanced LPS-induced expression of the pro-inflammatory cytokines interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) in RAW264.7 cells via activation of the c-Jun/Toll-like receptor 4 (TLR4) signaling axis.	Samarium	32-34	tumor necrosis factor	Mus musculus	167-176
33114200-6	2020	Surprisingly, it was found that SM significantly enhanced LPS-induced expression of the pro-inflammatory cytokines interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) in RAW264.7 cells via activation of the c-Jun/Toll-like receptor 4 (TLR4) signaling axis.	Samarium	32-34	interleukin 1 beta	Mus musculus	183-200
33114200-6	2020	Surprisingly, it was found that SM significantly enhanced LPS-induced expression of the pro-inflammatory cytokines interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) in RAW264.7 cells via activation of the c-Jun/Toll-like receptor 4 (TLR4) signaling axis.	Samarium	32-34	interleukin 1 alpha	Mus musculus	202-210
33114200-6	2020	Surprisingly, it was found that SM significantly enhanced LPS-induced expression of the pro-inflammatory cytokines interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) in RAW264.7 cells via activation of the c-Jun/Toll-like receptor 4 (TLR4) signaling axis.	Samarium	32-34	jun proto-oncogene	Mus musculus	252-257
33114200-6	2020	Surprisingly, it was found that SM significantly enhanced LPS-induced expression of the pro-inflammatory cytokines interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) in RAW264.7 cells via activation of the c-Jun/Toll-like receptor 4 (TLR4) signaling axis.	Samarium	32-34	toll-like receptor 4	Mus musculus	258-278
33114200-6	2020	Surprisingly, it was found that SM significantly enhanced LPS-induced expression of the pro-inflammatory cytokines interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) in RAW264.7 cells via activation of the c-Jun/Toll-like receptor 4 (TLR4) signaling axis.	Samarium	32-34	toll-like receptor 4	Mus musculus	280-284
33303166-8	2021	More importantly, by visualizing ONOO-, the probe was used to monitor the diagnosis of CCl4-induced toxic hepatitis in mice and evaluate the therapeutic efficacy of hepatoprotective medicines (NAC, SM, DDB).	Samarium	198-200	chemokine (C-C motif) ligand 4	Mus musculus	87-91
32687881-7	2020	After correction for TP, exercise-induced increase in sm-cTnI was caused by hemoconcentration alone.	Samarium	54-56	troponin I3, cardiac type	Homo sapiens	57-61
32791755-10	2020	CONCLUSIONS: Patients taking the DSM therapy had better effects in reducing the level of HbA1c, FPG, body weight, SBP and DBP than the DM and SM therapy.	Samarium	34-36	D-box binding PAR bZIP transcription factor	Homo sapiens	122-125
32434920-8	2020	We demonstrate that SM binds and recruits XPB to EBV promoters during lytic replication.	Samarium	20-22	ERCC excision repair 3, TFIIH core complex helicase subunit	Homo sapiens	42-45
28337641-11	2020	The levels of PSA were considerably reduced in SM-treated group compared to the controls, and a decrease in AR expression was observed when cells were treated with SM in the same pattern as a reduction in PSA.	Samarium	47-49	kallikrein related peptidase 3	Homo sapiens	14-17
28337641-11	2020	The levels of PSA were considerably reduced in SM-treated group compared to the controls, and a decrease in AR expression was observed when cells were treated with SM in the same pattern as a reduction in PSA.	Samarium	47-49	kallikrein related peptidase 3	Homo sapiens	205-208
28337641-11	2020	The levels of PSA were considerably reduced in SM-treated group compared to the controls, and a decrease in AR expression was observed when cells were treated with SM in the same pattern as a reduction in PSA.	Samarium	164-166	androgen receptor	Homo sapiens	108-110
32374871-5	2020	We further provide evidence that defective snRNAs without the Sm binding site are uridylated at the 3" end and associate with DIS3L2 3" 5" exoribonuclease and LSm proteins.	Samarium	62-64	DIS3 like 3'-5' exoribonuclease 2	Homo sapiens	126-132
31970839-2	2020	Sphingomyelin synthase 2 (SMS2) is involved in inflammatory diseases such as obesity and diabetes mellitus by regulation of the SM/ceramide balance.	Samarium	26-28	sphingomyelin synthase 2	Mus musculus	0-24
32408647-1	2020	The reaction of the Schiff base ligand o-OH-C6H4-CH=N-C(CH2OH)3, H4L, with Ni(O2CMe)2 4H2O and lanthanide nitrate salts in a 4 : 2 : 1 ratio lead to the formation of the trinuclear complexes [Ni2Ln(H3L)4(O2CMe)2](NO3) (Ln = Sm (1), Eu (2), Gd (3), Tb (4)).	Samarium	224-226	H4 clustered histone 7	Homo sapiens	65-68
31970839-6	2020	Reduced SM/ceramide balance in SMS2-KO tMEFs suppressed the attachment of EL4 cells through transcriptional reduction of ICAM-1 by the inhibition of NF-kappaB activation.	Samarium	8-10	sphingomyelin synthase 2	Mus musculus	31-35
31970839-6	2020	Reduced SM/ceramide balance in SMS2-KO tMEFs suppressed the attachment of EL4 cells through transcriptional reduction of ICAM-1 by the inhibition of NF-kappaB activation.	Samarium	8-10	intercellular adhesion molecule 1	Mus musculus	121-127
31746300-9	2020	The photodegradation ability of the ZnO @PAN membrane doped with cerium (Sm) was also investigated.	Samarium	73-75	adenosine deaminase 2	Homo sapiens	41-44
32129155-0	2020	Samarium enriches antitumor activity of ZnO nanoparticles via downregulation of CXCR4 receptor and cytochrome P450.	Samarium	0-8	C-X-C motif chemokine receptor 4	Homo sapiens	80-85
32129155-0	2020	Samarium enriches antitumor activity of ZnO nanoparticles via downregulation of CXCR4 receptor and cytochrome P450.	Samarium	0-8	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	99-114
32129155-6	2020	The in vivo experiment on mice bearing Ehrlich solid tumor revealed that intramuscular injection of samarium/zinc oxide downregulates the expressions of CXCR4 and PI3K/Akt/mammalian target of rapamycin pathway in respect to Ehrlich solid tumor group.	Samarium	100-108	chemokine (C-X-C motif) receptor 4	Mus musculus	153-158
32129155-6	2020	The in vivo experiment on mice bearing Ehrlich solid tumor revealed that intramuscular injection of samarium/zinc oxide downregulates the expressions of CXCR4 and PI3K/Akt/mammalian target of rapamycin pathway in respect to Ehrlich solid tumor group.	Samarium	100-108	thymoma viral proto-oncogene 1	Mus musculus	168-171
32129155-6	2020	The in vivo experiment on mice bearing Ehrlich solid tumor revealed that intramuscular injection of samarium/zinc oxide downregulates the expressions of CXCR4 and PI3K/Akt/mammalian target of rapamycin pathway in respect to Ehrlich solid tumor group.	Samarium	100-108	mechanistic target of rapamycin kinase	Homo sapiens	172-201
32129155-7	2020	Regarding the apoptotic biomarkers, samarium/zinc oxide upregulates the apoptotic biomarker; Bax accompanied with the mitotic catastrophe which was indicated by cell cycle arrest in G2 phase.	Samarium	36-44	BCL2 associated X, apoptosis regulator	Homo sapiens	93-96
32129155-8	2020	Moreover, samarium:zinc oxide nanoparticles exhibited minimum toxicity which was indicated by suppressed activities of cytochrome P450 and hepatic enzymes, including alanine transaminase and aspartate transaminase.	Samarium	10-18	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	119-134
31746300-0	2020	Sm doped ZnO nanowires@PAN nanofibrous membranes for photo-catalytic degradation of dye.	Samarium	0-2	adenosine deaminase 2	Homo sapiens	23-26
31746300-12	2020	CONCLUSION: Sm doped ZnO nanowires @PAN nanofibrous membranes were easily produced and could provide a novel process for degradation on dye decontamination.	Samarium	12-14	adenosine deaminase 2	Homo sapiens	36-39
31663330-3	2019	Here, aliovalent Sm3+ doped 0.4Pb(Mg1/3Nb2/3)O3-(0.6-x)PbZrO3-xPbTiO3 piezoelectric ceramics were fabricated by solid state method, where the optimized piezoelectric coefficient d33 = 910 pC/N, dielectric constant epsilonr = 4090 and Curie temperature TC =184  C, were obtained at x=0.352, being attributed to the synergistic contributions from the MPB and enhanced local structural heterogeneity.	Samarium	17-20	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	34-37
30583016-9	2019	Treatment with diacerein by itself and diacerein in combination with SM/SA stimulation reduced phosphorylation of FAK and STAT3, which is more pronounced in OA cells.	Samarium	69-71	protein tyrosine kinase 2	Homo sapiens	114-117
31664113-7	2019	And variation of Sm3+ ion concentration can control color emission, namely CIE chromaticity coordinates and correlated color temperature, finally to achieve white light emission (0.309,0.309) with CCT 6848 K, able to be a potential candidate for commercial lighting applications.	Samarium	17-21	CCT	Homo sapiens	197-200
31455723-4	2019	Whereas SMs inhibited interleukin-17 (IL-17) production and ameliorated TH17 cell-driven inflammation, they stimulated IL-22 secretion.	Samarium	8-11	interleukin 17A	Homo sapiens	22-36
31455723-4	2019	Whereas SMs inhibited interleukin-17 (IL-17) production and ameliorated TH17 cell-driven inflammation, they stimulated IL-22 secretion.	Samarium	8-11	interleukin 17A	Homo sapiens	38-43
31455723-7	2019	Last, SMs also increased IL-9 and IL-13 production and, under competing conditions, favored the differentiation of naive CD4+ T cells into TH2 cells rather than TH17 cells.	Samarium	6-9	interleukin 9	Homo sapiens	25-29
31455723-7	2019	Last, SMs also increased IL-9 and IL-13 production and, under competing conditions, favored the differentiation of naive CD4+ T cells into TH2 cells rather than TH17 cells.	Samarium	6-9	interleukin 13	Homo sapiens	34-39
31455723-7	2019	Last, SMs also increased IL-9 and IL-13 production and, under competing conditions, favored the differentiation of naive CD4+ T cells into TH2 cells rather than TH17 cells.	Samarium	6-9	CD4 molecule	Homo sapiens	121-124
31943985-1	2019	A samarium-doped carbon aerogel cathode (CA-Sm) for high-performance lithium-sulfur batteries was successfully synthesized from a Sm-containing metal-organic framework (MOF) as a template through a sol-gel reaction and a carbonization process.	Samarium	2-10	lysine acetyltransferase 8	Homo sapiens	144-173
30583016-9	2019	Treatment with diacerein by itself and diacerein in combination with SM/SA stimulation reduced phosphorylation of FAK and STAT3, which is more pronounced in OA cells.	Samarium	69-71	signal transducer and activator of transcription 3	Homo sapiens	122-127
30845761-8	2019	Finally, SMs showed a better hepatoprotective effect against carbon tetrachloride (CCl4)-induced hepatic injury in vivo than free 6-shogaol.	Samarium	9-12	C-C motif chemokine ligand 4	Homo sapiens	83-87
29619068-8	2018	These findings suggest that AM/SM showed protective and therapeutic effects in LPS-induced ALI rat through modulating TLR-4 signaling pathways.	Samarium	31-33	toll-like receptor 4	Rattus norvegicus	118-123
31486323-4	2019	SM molecules are HSP90 inhibitors that bind to the C-terminus of HSP90 and do not induce a heat shock response.	Samarium	0-2	heat shock protein 90 alpha family class A member 1	Homo sapiens	17-22
31486323-4	2019	SM molecules are HSP90 inhibitors that bind to the C-terminus of HSP90 and do not induce a heat shock response.	Samarium	0-2	heat shock protein 90 alpha family class A member 1	Homo sapiens	65-70
30243987-2	2019	Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated.	Samarium	19-21	sphingomyelin synthase 1	Mus musculus	34-38
30243987-2	2019	Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated.	Samarium	19-21	beta-site APP cleaving enzyme 1	Mus musculus	198-229
30243987-2	2019	Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated.	Samarium	19-21	beta-site APP cleaving enzyme 1	Mus musculus	231-236
30243987-2	2019	Elevated levels of SM synthase 1 (SMS1), which catalyzes the synthesis of SM from ceramide and phosphatidylcholine, have been observed in the brains of Alzheimer"s disease (AD), where expression of beta-site APP cleaving enzyme 1 (BACE1), a rate limiting enzyme in amyloid-beta (Abeta) generation, are upregulated.	Samarium	19-21	amyloid beta (A4) precursor protein	Mus musculus	279-284
30279221-7	2018	Tissue-specific ablation studies revealed that hepatic ABCA1 determines plasma HxCer and SM levels; that ablation of MTP and ABCA1 in the liver and intestine reduces plasma HxCer, SM, and ceramide levels; and that hepatic and intestinal MTP contribute to plasma ceramide levels, whereas only hepatic MTP modulates plasma SM levels.	Samarium	89-91	ATP binding cassette subfamily A member 1	Homo sapiens	55-60
30384686-0	2018	Samarium cation (Sm+) reactions with H2, D2, and HD: SmH+ bond energy and mechanistic insights from guided ion beam and theoretical studies.	Samarium	17-20	coiled-coil domain containing 103	Homo sapiens	53-56
30055105-2	2018	Based on their endogenous antagonist, Smac/DIABLO, mimic compounds (Smac-mimetics, SMs) have been developed to inhibit IAPs prosurvival activity, showing promising effects in advanced phases of clinical trials.	Samarium	83-86	diablo IAP-binding mitochondrial protein	Homo sapiens	38-42
30055105-2	2018	Based on their endogenous antagonist, Smac/DIABLO, mimic compounds (Smac-mimetics, SMs) have been developed to inhibit IAPs prosurvival activity, showing promising effects in advanced phases of clinical trials.	Samarium	83-86	diablo IAP-binding mitochondrial protein	Homo sapiens	43-49
29567647-2	2018	Genome-wide studies have identified neutral SMase-2 (nSMase2), an enzyme generating ceramide from SM, as a potential repressor for hepatocellular carcinoma.	Samarium	44-46	sphingomyelin phosphodiesterase 3, neutral	Mus musculus	53-60
29567647-9	2018	CD133(+) cells showed strong labeling for SM and ceramide.	Samarium	42-44	prominin 1	Mus musculus	0-5
29244499-5	2018	The observed barrier for oxidation is shown to likely correspond to the energy of the crossing between surfaces corresponding to the ground state electronic configuration of Sm+ (8F,4f66s1) and an excited surface having two electrons in the valence space (excluding 4f), which are needed to form the strong SmO+ bond.	Samarium	174-177	smoothened, frizzled class receptor	Homo sapiens	307-310
30541834-12	2019	We show that SM binds to and colocalizes DHX9 and may counteract the antiviral function of DHX9.	Samarium	13-15	DExH-box helicase 9	Homo sapiens	41-45
30541834-12	2019	We show that SM binds to and colocalizes DHX9 and may counteract the antiviral function of DHX9.	Samarium	13-15	DExH-box helicase 9	Homo sapiens	91-95
28665401-3	2017	However, TNF derived from other cellular sources, such as cytotoxic lymphocytes (CLs) within the tumor, may also contribute to the anti-tumor activity of SMs.	Samarium	154-157	tumor necrosis factor	Sus scrofa	9-12
30227401-11	2018	Taken together, our results show that the effects of OP-D and SM-I were also mediated by the activation of the PI3K/Akt/eNOS signaling pathway, while inhibition of the NF-kappaB signaling pathway and antioxidant and anti-apoptotic effects were involved in the cardioprotective effects of OP-D and SM-I.	Samarium	62-64	AKT serine/threonine kinase 1	Rattus norvegicus	116-119
28939895-3	2017	Here we show that ENG selectively interacts with sphingomyelin(SM)-18:0 which promotes its clustering with metalloproteinase 14 (MMP14) in SM-18:0 enriched lipid rafts of the apical syncytial membranes from PE placenta where ENG is cleaved by MMP14 into sENG.	Samarium	63-65	endoglin	Homo sapiens	18-21
28653654-0	2017	MPP1 interacts with DOPC/SM/Cholesterol in an artificial membrane system using Langmuir-Blodgett monolayer.	Samarium	25-27	MAGUK p55 scaffold protein 1	Homo sapiens	0-4
28939895-3	2017	Here we show that ENG selectively interacts with sphingomyelin(SM)-18:0 which promotes its clustering with metalloproteinase 14 (MMP14) in SM-18:0 enriched lipid rafts of the apical syncytial membranes from PE placenta where ENG is cleaved by MMP14 into sENG.	Samarium	63-65	matrix metallopeptidase 14	Homo sapiens	129-134
28939895-3	2017	Here we show that ENG selectively interacts with sphingomyelin(SM)-18:0 which promotes its clustering with metalloproteinase 14 (MMP14) in SM-18:0 enriched lipid rafts of the apical syncytial membranes from PE placenta where ENG is cleaved by MMP14 into sENG.	Samarium	63-65	endoglin	Homo sapiens	225-228
28939895-3	2017	Here we show that ENG selectively interacts with sphingomyelin(SM)-18:0 which promotes its clustering with metalloproteinase 14 (MMP14) in SM-18:0 enriched lipid rafts of the apical syncytial membranes from PE placenta where ENG is cleaved by MMP14 into sENG.	Samarium	63-65	matrix metallopeptidase 14	Homo sapiens	243-248
28881553-11	2017	AKAP12 methylation-positive rate was significantly higher in hepatomas than SMs (54.9% vs. 10.2%, P&lt;0.001).	Samarium	76-79	A-kinase anchoring protein 12	Homo sapiens	0-6
27738742-6	2017	In this study, we demonstrate that sulfur mustard (bis-(2-chloroethyl) sulfide, SM) activates the human TRPA1 (hTRPA1) in a dose-dependent manner measured by the increase in intracellular Ca2+ concentration ([Ca2+]i).	Samarium	80-82	transient receptor potential cation channel subfamily A member 1	Homo sapiens	104-109
27738742-12	2017	Taken together, our results provide evidence that SM-dependent activation of hTRPA1 can be diminished by NAC treatment, suggesting a direct interaction of NAC and the hTRPA1 cation channel.	Samarium	50-52	X-linked Kx blood group	Homo sapiens	155-158
27738742-12	2017	Taken together, our results provide evidence that SM-dependent activation of hTRPA1 can be diminished by NAC treatment, suggesting a direct interaction of NAC and the hTRPA1 cation channel.	Samarium	50-52	transient receptor potential cation channel subfamily A member 1	Homo sapiens	167-173
28516506-1	2017	The geometric and electronic ground-state structures of 30 isomers of six MS4 molecules (M=Group 8 metals Fe, Ru, Os, Hs, Sm, and Pu) have been studied by using quantum-chemical density functional theory and correlated wavefunction approaches.	Samarium	122-124	MS4	Homo sapiens	74-77
27738742-6	2017	In this study, we demonstrate that sulfur mustard (bis-(2-chloroethyl) sulfide, SM) activates the human TRPA1 (hTRPA1) in a dose-dependent manner measured by the increase in intracellular Ca2+ concentration ([Ca2+]i).	Samarium	80-82	transient receptor potential cation channel subfamily A member 1	Homo sapiens	111-117
27738742-9	2017	Here, we demonstrate that N-acetyl-L-cysteine (NAC) prevents SM-induced hTRPA1-activation.	Samarium	61-63	X-linked Kx blood group	Homo sapiens	47-50
27738742-9	2017	Here, we demonstrate that N-acetyl-L-cysteine (NAC) prevents SM-induced hTRPA1-activation.	Samarium	61-63	transient receptor potential cation channel subfamily A member 1	Homo sapiens	72-78
27738742-12	2017	Taken together, our results provide evidence that SM-dependent activation of hTRPA1 can be diminished by NAC treatment, suggesting a direct interaction of NAC and the hTRPA1 cation channel.	Samarium	50-52	transient receptor potential cation channel subfamily A member 1	Homo sapiens	77-83
27738742-12	2017	Taken together, our results provide evidence that SM-dependent activation of hTRPA1 can be diminished by NAC treatment, suggesting a direct interaction of NAC and the hTRPA1 cation channel.	Samarium	50-52	X-linked Kx blood group	Homo sapiens	105-108
26175473-4	2015	Mobilization of membrane lipids by GM2AP was also inhibited in the presence of cholesterol or SM, as revealed by surface plasmon resonance studies.	Samarium	94-96	ganglioside GM2 activator	Homo sapiens	35-40
28435958-8	2017	The observed barrier for oxidation is shown to likely correspond to the energy of the crossing between surfaces corresponding to the ground state electronic configuration of Sm+ (8F,4f66s1) and an excited surface having two electrons in the valence space (excluding 4f), which are needed to form the strong SmO+ bond.	Samarium	174-177	smoothened, frizzled class receptor	Homo sapiens	307-310
26247826-8	2016	The increased myeloperoxidase activity and beta-glucuronidase level exhibited the degranulation of neutrophils due to SM toxicity in lung.	Samarium	118-120	myeloperoxidase	Mus musculus	14-29
26247826-8	2016	The increased myeloperoxidase activity and beta-glucuronidase level exhibited the degranulation of neutrophils due to SM toxicity in lung.	Samarium	118-120	glucuronidase, beta	Mus musculus	43-61
27129149-9	2016	IAP antagonists, including SM-164, lacked mutagenic activity.	Samarium	27-29	alkaline phosphatase, intestinal	Homo sapiens	0-3
26764042-4	2016	After infection with the neurotropic WNV, mice deficient in acid sphingomyelinase (ASM), which accumulate high levels of SM in their tissues, displayed exacerbated infection.	Samarium	84-86	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	60-81
25601960-3	2015	To test this prediction, we compared the lipid efflux activity of ABCB4 and ABCA1 under SM depletion induced by two different types of inhibitors for SM synthesis, myriocin and (1R,3S)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide, in human embryonic kidney 293 and baby hamster kidney cells.	Samarium	88-90	ATP binding cassette subfamily B member 4	Homo sapiens	66-71
26030368-6	2015	We explored structural idiosyncrasies between CY and CyPA to screen in silico nearly 9 million small molecules (SM) against the CY PPIase pocket and identify SMs with selective bioactivity toward STAT3, hnRNPA2B1, or M-opsin proteostasis.	Samarium	158-161	peptidylprolyl isomerase A	Homo sapiens	53-57
26030368-6	2015	We explored structural idiosyncrasies between CY and CyPA to screen in silico nearly 9 million small molecules (SM) against the CY PPIase pocket and identify SMs with selective bioactivity toward STAT3, hnRNPA2B1, or M-opsin proteostasis.	Samarium	158-161	signal transducer and activator of transcription 3	Homo sapiens	196-201
26256047-7	2015	Airway treatment with SM resulted in displacement of CINC-1 and NE from complexation with bronchio-epithelial HS/syndecan-1, dissipating the chemokine gradient for neutrophil flux across to the bronchial lumen.	Samarium	22-24	C-X-C motif chemokine ligand 1	Rattus norvegicus	53-59
26256047-7	2015	Airway treatment with SM resulted in displacement of CINC-1 and NE from complexation with bronchio-epithelial HS/syndecan-1, dissipating the chemokine gradient for neutrophil flux across to the bronchial lumen.	Samarium	22-24	elastase, neutrophil expressed	Rattus norvegicus	64-66
26256047-7	2015	Airway treatment with SM resulted in displacement of CINC-1 and NE from complexation with bronchio-epithelial HS/syndecan-1, dissipating the chemokine gradient for neutrophil flux across to the bronchial lumen.	Samarium	22-24	syndecan 1	Rattus norvegicus	113-123
31973267-5	2015	SHMeQ[6] formed adducts of SHMeQ[6] with aqua complexes of lanthanide cations ([Ln(H2 O)8 ]3+ ); for SHMeQ[6]-Ln(NO3 )3 -CdCl2 -HCl systems (Ln=Gd-Lu), no solid crystals were obtained from systems that contained La, Ce, Pr, Nd, Sm, or Eu.	Samarium	228-230	NBL1, DAN family BMP antagonist	Homo sapiens	113-116
31973267-6	2015	Whereas solid crystals of adducts of SHMeQ[6] with aqua complexes of lanthanide cations (Ln=Sm-Lu) formed SHMeQ[6]-Ln(NO3 )3 systems in neutral solution, no solid crystals were obtained from systems that contained La, Ce, Pr, or Nd.	Samarium	92-94	NBL1, DAN family BMP antagonist	Homo sapiens	118-121
25670801-8	2015	Inhibition of SM synthesis impaired the acquisition of mature AJs, evoking a disintegration-like process reflected by the dissipation of E-cadherin and beta- and alpha-catenins from the AJ complex.	Samarium	14-16	cadherin 1	Canis lupus familiaris	137-147
25601960-3	2015	To test this prediction, we compared the lipid efflux activity of ABCB4 and ABCA1 under SM depletion induced by two different types of inhibitors for SM synthesis, myriocin and (1R,3S)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide, in human embryonic kidney 293 and baby hamster kidney cells.	Samarium	88-90	ATP binding cassette subfamily A member 1	Homo sapiens	76-81
25591890-7	2015	The present findings strongly suggest that t(he main reason for realization of the Tc &gt;50 K observed in RE-1111 compounds (RE: Pr, Sm, and Gd) at ambient pressure is the merging of SC1 and SC2.	Samarium	134-136	transcription factor 19	Homo sapiens	184-187
24100952-13	2014	Blast injured SMs demonstrated distinct areas of cortical thinning in the STG and SFG.	Samarium	14-17	chromosome 6 open reading frame 15	Homo sapiens	74-77
25127551-3	2014	In the present studies, we tested a novel, bifunctional anti-inflammatory prodrug (NDH 4338) designed to target cyclooxygenase 2 (COX2), an enzyme that generates inflammatory eicosanoids, and acetylcholinesterase, an enzyme mediating activation of cholinergic inflammatory pathways in a model of SM-induced skin injury.	Samarium	296-298	prostaglandin-endoperoxide synthase 2	Mus musculus	130-134
25127551-6	2014	After 96 h, SM was found to induce skin injury characterized by edema, epidermal hyperplasia, loss of the differentiation marker, keratin 10 (K10), upregulation of the skin wound marker keratin 6 (K6), disruption of the basement membrane anchoring protein laminin 322, and increased expression of epidermal COX2.	Samarium	12-14	keratin 10	Mus musculus	130-140
25127551-6	2014	After 96 h, SM was found to induce skin injury characterized by edema, epidermal hyperplasia, loss of the differentiation marker, keratin 10 (K10), upregulation of the skin wound marker keratin 6 (K6), disruption of the basement membrane anchoring protein laminin 322, and increased expression of epidermal COX2.	Samarium	12-14	keratin 10	Mus musculus	142-145
25127551-6	2014	After 96 h, SM was found to induce skin injury characterized by edema, epidermal hyperplasia, loss of the differentiation marker, keratin 10 (K10), upregulation of the skin wound marker keratin 6 (K6), disruption of the basement membrane anchoring protein laminin 322, and increased expression of epidermal COX2.	Samarium	12-14	keratin 6	Mus musculus	197-199
25127551-6	2014	After 96 h, SM was found to induce skin injury characterized by edema, epidermal hyperplasia, loss of the differentiation marker, keratin 10 (K10), upregulation of the skin wound marker keratin 6 (K6), disruption of the basement membrane anchoring protein laminin 322, and increased expression of epidermal COX2.	Samarium	12-14	prostaglandin-endoperoxide synthase 2	Mus musculus	307-311
25485894-3	2014	ABCG1-GFP expression increased the amount of mobile, non-sphingomyelin(SM)-associated cholesterol at the PM and LE, but not the amount of SM-associated-cholesterol or SM.	Samarium	71-73	ATP binding cassette subfamily G member 1	Homo sapiens	0-5
25339683-11	2014	Preincubation of vesicles containing SM with acid sphingomyelinase (ASM) (SM phosphodiesterase, EC 3.1.4.12) results in hydrolysis of SM to ceramide (Cer), which enhances cholesterol transfer.	Samarium	37-39	sphingomyelin phosphodiesterase 1	Homo sapiens	45-66
25339683-11	2014	Preincubation of vesicles containing SM with acid sphingomyelinase (ASM) (SM phosphodiesterase, EC 3.1.4.12) results in hydrolysis of SM to ceramide (Cer), which enhances cholesterol transfer.	Samarium	37-39	sphingomyelin phosphodiesterase 1	Homo sapiens	68-71
25339683-11	2014	Preincubation of vesicles containing SM with acid sphingomyelinase (ASM) (SM phosphodiesterase, EC 3.1.4.12) results in hydrolysis of SM to ceramide (Cer), which enhances cholesterol transfer.	Samarium	69-71	sphingomyelin phosphodiesterase 1	Homo sapiens	45-66
25339683-13	2014	Anionic phospholipids derived from the plasma membrane (phosphatidylglycerol and phosphatidic acid) stimulate SM and phosphatidylcholine hydrolysis by ASM more effectively than BMP, which is generated during endocytosis.	Samarium	110-112	sphingomyelin phosphodiesterase 1	Homo sapiens	151-154
25260089-6	2014	To discover a functional food for regulating glucose and energy homeostasis, we evaluated the effect of an aqueous ethanolic extract (AEE) of SM on GLP-1 release from enteroendocrine NCI-H716 cells.	Samarium	142-144	glucagon	Homo sapiens	148-153
24011952-8	2013	Missense or nonsense mutations of CTNNB1 and AXIN1 were higher in GN-CCPs (14.8%, both) than CGA-SMs (5.3%, both).	Samarium	97-100	chromogranin A	Homo sapiens	93-96
24011952-9	2013	Missense mutations of AXIN2 were higher in GN-CCPs (25.9%) than in CGA-SMs (10.5%).	Samarium	71-74	axin 2	Homo sapiens	22-27
24011952-9	2013	Missense mutations of AXIN2 were higher in GN-CCPs (25.9%) than in CGA-SMs (10.5%).	Samarium	71-74	chromogranin A	Homo sapiens	67-70
23851002-10	2013	p38 knockdown reduced SM-induced secretion of all the cytokines examined, whereas significant reduction in SM-induced cytokine secretion was only observed with TNF-alpha and IL-6 following MK2 knockdown.	Samarium	22-24	mitogen-activated protein kinase 14	Homo sapiens	0-3
23933563-5	2013	Adjacent Sm atoms were linked via the mu2-bridging carboxylate groups of the IBA ligands to generate a binuclear building unit.	Samarium	9-11	adaptor related protein complex 1 subunit mu 2	Homo sapiens	38-41
23851002-10	2013	p38 knockdown reduced SM-induced secretion of all the cytokines examined, whereas significant reduction in SM-induced cytokine secretion was only observed with TNF-alpha and IL-6 following MK2 knockdown.	Samarium	107-109	tumor necrosis factor	Homo sapiens	160-169
23851002-10	2013	p38 knockdown reduced SM-induced secretion of all the cytokines examined, whereas significant reduction in SM-induced cytokine secretion was only observed with TNF-alpha and IL-6 following MK2 knockdown.	Samarium	107-109	interleukin 6	Homo sapiens	174-178
23851002-10	2013	p38 knockdown reduced SM-induced secretion of all the cytokines examined, whereas significant reduction in SM-induced cytokine secretion was only observed with TNF-alpha and IL-6 following MK2 knockdown.	Samarium	107-109	MAPK activated protein kinase 2	Homo sapiens	189-192
24369591-2	2013	Among these lipids, sphingomyelin(SM) and sphingosine 1-phosphate (Sph-1-P) are proposed to be involved in the pathogenesis of atherosclerosis: SM is abundant in atherosclerotic lesions and Sph-1-P is bound to HDL and attributes to the anti-atherosclerotic properties of HDL at least partly.	Samarium	144-146	ankyrin 1	Homo sapiens	67-72
24369591-2	2013	Among these lipids, sphingomyelin(SM) and sphingosine 1-phosphate (Sph-1-P) are proposed to be involved in the pathogenesis of atherosclerosis: SM is abundant in atherosclerotic lesions and Sph-1-P is bound to HDL and attributes to the anti-atherosclerotic properties of HDL at least partly.	Samarium	144-146	ankyrin 1	Homo sapiens	190-195
23840254-8	2013	This is the first report on the role of SM in regulating the PPAR gamma -mediated regulation of candidate genes involved in metabolism in peripheral tissues in vivo.	Samarium	40-42	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	61-71
22763020-6	2013	The results suggest that SMS stimulation induces a significant increase (p &lt; 0.05, Wilcoxon sign-ranked test) of relative power for low frequency bands (i.e., theta and alpha bands) and a significant decrease (p &lt; 0.05, Wilcoxon sign-ranked test) for fast rhythms (i.e., beta1, beta2 and gamma bands).	Samarium	25-28	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	277-282
22763020-6	2013	The results suggest that SMS stimulation induces a significant increase (p &lt; 0.05, Wilcoxon sign-ranked test) of relative power for low frequency bands (i.e., theta and alpha bands) and a significant decrease (p &lt; 0.05, Wilcoxon sign-ranked test) for fast rhythms (i.e., beta1, beta2 and gamma bands).	Samarium	25-28	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	284-289
23147735-5	2013	SM-295291 and SM-369926 showed intravenous pharmacokinetics similar to those of meropenem in terms of half-life in monkeys (0.4 h) and were stable against human dehydropeptidase I.	Samarium	0-2	dipeptidase 1	Homo sapiens	161-179
23147735-5	2013	SM-295291 and SM-369926 showed intravenous pharmacokinetics similar to those of meropenem in terms of half-life in monkeys (0.4 h) and were stable against human dehydropeptidase I.	Samarium	14-16	dipeptidase 1	Homo sapiens	161-179